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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for VAX1_GSX2

Z-value: 0.66

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Transcription factors associated with VAX1_GSX2

Gene Symbol	Gene ID	Gene Info
VAX1 Ensembl NCBI GeneCards UniProt	ENSG00000148704.8	ventral anterior homeobox 1
GSX2 Ensembl NCBI GeneCards UniProt	ENSG00000180613.6	GS homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr4_54948793_54948944	GSX2	17330	0.142181	-0.69	4.0e-02	Click!
chr4_54964029_54964180	GSX2	2094	0.266504	-0.69	4.1e-02	Click!
chr4_54957879_54958339	GSX2	8089	0.160066	-0.51	1.6e-01	Click!
chr4_54966607_54966829	GSX2	378	0.827536	-0.33	3.8e-01	Click!
chr4_54965462_54965613	GSX2	661	0.655801	-0.28	4.7e-01	Click!
chr10_118896728_118897230	VAX1	588	0.732908	-0.55	1.2e-01	Click!
chr10_118896343_118896719	VAX1	1036	0.514968	-0.52	1.5e-01	Click!
chr10_118897625_118897901	VAX1	49	0.974109	-0.44	2.4e-01	Click!
chr10_118898702_118898860	VAX1	969	0.539904	-0.28	4.7e-01	Click!
chr10_118893555_118893737	VAX1	3921	0.212192	-0.20	6.0e-01	Click!

Activity of the VAX1_GSX2 motif across conditions

Conditions sorted by the z-value of the VAX1_GSX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_19815653_19816006	1.09	SH3KBP1	SH3-domain kinase binding protein 1	2040	0.46
chr14_22993528_22993679	0.58	TRAJ15	T cell receptor alpha joining 15	4977	0.12
chr5_35863316_35863652	0.57	IL7R	interleukin 7 receptor	6490	0.21
chr1_100852790_100852941	0.48	ENSG00000216067	.	8534	0.21
chr14_22955963_22956254	0.45	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	63	0.95
chr5_67576888_67577103	0.44	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	860	0.74
chr6_154568354_154568864	0.44	IPCEF1	interaction protein for cytohesin exchange factors 1	53	0.99
chr13_41555714_41555943	0.42	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr12_112438598_112438749	0.40	TMEM116	transmembrane protein 116	5116	0.18
chr1_226919798_226919959	0.40	ITPKB	inositol-trisphosphate 3-kinase B	5281	0.26
chr18_67623845_67624178	0.39	CD226	CD226 molecule	105	0.98
chr6_91004568_91004758	0.39	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	1798	0.43
chr3_168442261_168442412	0.39	ENSG00000207717	.	172694	0.04
chr13_99953854_99954138	0.38	GPR183	G protein-coupled receptor 183	5663	0.22
chr3_151961363_151961565	0.38	MBNL1	muscleblind-like splicing regulator 1	24365	0.2
chr2_204572133_204572358	0.38	CD28	CD28 molecule	829	0.71
chr3_108543496_108543820	0.37	TRAT1	T cell receptor associated transmembrane adaptor 1	2039	0.42
chr9_92032170_92032321	0.36	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1503	0.49
chr14_22182172_22182323	0.36	OR4E2	olfactory receptor, family 4, subfamily E, member 2	48950	0.13
chr14_22947593_22947744	0.36	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr3_108541842_108541993	0.35	TRAT1	T cell receptor associated transmembrane adaptor 1	298	0.94
chr7_106822662_106822813	0.35	HBP1	HMG-box transcription factor 1	2374	0.31
chr4_143321296_143321548	0.35	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	30990	0.26
chr5_35854839_35855004	0.34	IL7R	interleukin 7 receptor	1476	0.43
chr4_180274632_180274783	0.34	ENSG00000212191	.	667597	0.0
chr2_161995560_161995711	0.33	TANK	TRAF family member-associated NFKB activator	2169	0.37
chr5_130882612_130883040	0.33	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14100	0.29
chr4_124343109_124343622	0.33	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	22242	0.29
chr7_39170814_39170965	0.33	POU6F2	POU class 6 homeobox 2	45428	0.18
chrX_1324594_1325309	0.33	CRLF2	cytokine receptor-like factor 2	6576	0.2
chr1_100887767_100887999	0.32	ENSG00000216067	.	43552	0.14
chr21_32559881_32560032	0.32	TIAM1	T-cell lymphoma invasion and metastasis 1	57417	0.15
chr7_38400564_38400715	0.32	AMPH	amphiphysin	102074	0.08
chrX_78400540_78401325	0.32	GPR174	G protein-coupled receptor 174	25537	0.27
chr10_6626003_6626633	0.32	PRKCQ	protein kinase C, theta	4055	0.36
chr1_192546230_192546423	0.32	RGS1	regulator of G-protein signaling 1	1423	0.45
chr5_130617597_130618118	0.31	CDC42SE2	CDC42 small effector 2	18064	0.27
chr6_37410160_37410312	0.31	CMTR1	cap methyltransferase 1	9240	0.22
chr15_86235334_86235485	0.31	RP11-815J21.1		8931	0.12
chr7_83944312_83944463	0.31	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	119626	0.07
chr7_7465159_7465310	0.31	COL28A1	collagen, type XXVIII, alpha 1	11832	0.28
chr13_42849044_42849223	0.30	AKAP11	A kinase (PRKA) anchor protein 11	2844	0.38
chr3_30658412_30658563	0.30	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	10394	0.3
chr12_40010729_40010948	0.30	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	2715	0.32
chr15_81597008_81597159	0.29	IL16	interleukin 16	5326	0.21
chr1_186291714_186291865	0.29	ENSG00000202025	.	10729	0.17
chr1_234544831_234544982	0.29	COA6	cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)	35459	0.12
chr5_156630276_156630427	0.29	CTB-4E7.1		21039	0.11
chr17_37933702_37934037	0.29	IKZF3	IKAROS family zinc finger 3 (Aiolos)	609	0.66
chr1_160614457_160614608	0.29	SLAMF1	signaling lymphocytic activation molecule family member 1	2279	0.26
chr4_154411300_154411567	0.28	KIAA0922	KIAA0922	23932	0.22
chr14_22977019_22977170	0.28	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	20923	0.09
chr5_39198391_39198564	0.28	FYB	FYN binding protein	4652	0.32
chr8_8203302_8203453	0.28	SGK223	Tyrosine-protein kinase SgK223	35880	0.18
chr9_20242645_20242902	0.28	ENSG00000221744	.	52229	0.16
chr9_134603046_134603230	0.28	ENSG00000240853	.	2284	0.32
chr11_2819893_2820044	0.28	KCNQ1-AS1	KCNQ1 antisense RNA 1	62830	0.09
chr1_29253817_29254129	0.28	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chr9_98188423_98189086	0.28	PTCH1	patched 1	54013	0.12
chr7_110732102_110732377	0.27	LRRN3	leucine rich repeat neuronal 3	1140	0.59
chr12_47604114_47604265	0.27	PCED1B	PC-esterase domain containing 1B	5863	0.23
chr9_95730621_95730837	0.27	FGD3	FYVE, RhoGEF and PH domain containing 3	4486	0.25
chrX_57022329_57022623	0.27	SPIN3	spindlin family, member 3	507	0.84
chr17_64327814_64327965	0.27	PRKCA	protein kinase C, alpha	28945	0.16
chr21_32555155_32555306	0.27	TIAM1	T-cell lymphoma invasion and metastasis 1	52691	0.16
chrX_72434847_72435271	0.27	NAP1L2	nucleosome assembly protein 1-like 2	375	0.91
chr12_47611625_47611801	0.27	PCED1B	PC-esterase domain containing 1B	1332	0.49
chr10_13829690_13829841	0.27	RP11-353M9.1		58382	0.09
chr14_22977314_22977663	0.27	TRAJ15	T cell receptor alpha joining 15	21092	0.09
chr14_22984428_22984696	0.27	TRAJ15	T cell receptor alpha joining 15	14018	0.1
chr1_158903283_158903483	0.27	PYHIN1	pyrin and HIN domain family, member 1	2025	0.36
chr16_24693339_24693490	0.27	TNRC6A	trinucleotide repeat containing 6A	47602	0.17
chr18_21581201_21581352	0.26	TTC39C	tetratricopeptide repeat domain 39C	8539	0.18
chr6_143263290_143263441	0.26	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	2973	0.34
chr17_33373915_33374211	0.26	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	4693	0.13
chr13_99957828_99957979	0.26	GPR183	G protein-coupled receptor 183	1756	0.38
chr3_135909805_135909956	0.26	MSL2	male-specific lethal 2 homolog (Drosophila)	3516	0.32
chr4_135385341_135385492	0.26	PABPC4L	poly(A) binding protein, cytoplasmic 4-like	262513	0.02
chr15_87678295_87678446	0.26	RP11-133L19.1		146713	0.05
chr14_102280520_102280788	0.26	CTD-2017C7.2		3996	0.17
chr16_86638626_86639076	0.26	FOXL1	forkhead box L1	26736	0.16
chr2_191274024_191274175	0.26	MFSD6	major facilitator superfamily domain containing 6	1018	0.56
chr15_60874237_60874501	0.26	RORA	RAR-related orphan receptor A	10371	0.22
chr10_47640402_47640757	0.25	ANTXRLP1	anthrax toxin receptor-like pseudogene 1	4212	0.25
chr6_474668_474819	0.25	RP1-20B11.2		49428	0.17
chr15_94009405_94009556	0.25	ENSG00000212063	.	179928	0.03
chr14_71454929_71455080	0.25	PCNX	pecanex homolog (Drosophila)	24744	0.26
chrY_1274756_1275442	0.25	NA	NA	> 10⁶	NA
chr13_41372571_41372761	0.25	SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	5372	0.18
chr6_100722020_100722171	0.25	RP1-121G13.2		152899	0.04
chr4_39032194_39032374	0.24	TMEM156	transmembrane protein 156	1757	0.38
chr1_211526219_211526370	0.24	TRAF5	TNF receptor-associated factor 5	6588	0.27
chr4_99565395_99565546	0.24	TSPAN5	tetraspanin 5	13316	0.22
chr5_35861092_35861243	0.24	IL7R	interleukin 7 receptor	4173	0.24
chr17_75456326_75456913	0.24	SEPT9	septin 9	4171	0.18
chr4_40220062_40220213	0.24	RHOH	ras homolog family member H	18173	0.2
chr5_159896012_159896214	0.24	ENSG00000265237	.	5296	0.18
chr17_78705219_78705370	0.24	RP11-28G8.1		74138	0.1
chr7_137680780_137680931	0.24	CREB3L2	cAMP responsive element binding protein 3-like 2	5938	0.22
chr7_78902475_78902626	0.24	ENSG00000212482	.	70138	0.13
chrX_12862286_12862452	0.24	TLR7	toll-like receptor 7	22833	0.19
chr13_97879341_97880219	0.24	MBNL2	muscleblind-like splicing regulator 2	5171	0.33
chr2_158299843_158300108	0.24	CYTIP	cytohesin 1 interacting protein	679	0.68
chr3_95425254_95425405	0.24	ENSG00000221477	.	460417	0.01
chr2_235398820_235398971	0.24	ARL4C	ADP-ribosylation factor-like 4C	6349	0.34
chr8_8727017_8727210	0.24	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	24042	0.18
chr4_143488164_143488362	0.23	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	6441	0.35
chr13_99227135_99227286	0.23	STK24	serine/threonine kinase 24	1907	0.32
chr14_74724486_74725063	0.23	VSX2	visual system homeobox 2	18599	0.14
chr7_138777634_138777825	0.23	ZC3HAV1	zinc finger CCCH-type, antiviral 1	13716	0.2
chr17_47766049_47766200	0.23	SPOP	speckle-type POZ protein	10528	0.14
chr1_25887536_25887687	0.23	LDLRAP1	low density lipoprotein receptor adaptor protein 1	17540	0.19
chr3_111261315_111261845	0.23	CD96	CD96 molecule	583	0.82
chr1_26452753_26452998	0.23	PDIK1L	PDLIM1 interacting kinase 1 like	14535	0.1
chr6_24934739_24934890	0.23	FAM65B	family with sequence similarity 65, member B	1374	0.5
chr2_207395158_207395309	0.23	ADAM23	ADAM metallopeptidase domain 23	64326	0.11
chr2_235359483_235359634	0.23	ARL4C	ADP-ribosylation factor-like 4C	45686	0.21
chr1_39500021_39500217	0.23	NDUFS5	NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)	8129	0.18
chrX_78196869_78197083	0.23	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	3853	0.37
chr11_82882204_82882391	0.23	PCF11	PCF11 cleavage and polyadenylation factor subunit	4	0.97
chr5_110560941_110561277	0.22	CAMK4	calcium/calmodulin-dependent protein kinase IV	1325	0.51
chr3_18477572_18477723	0.22	SATB1	SATB homeobox 1	902	0.62
chr1_70319695_70319846	0.22	ENSG00000240692	.	25505	0.25
chr5_44684027_44684178	0.22	ENSG00000263556	.	32190	0.23
chr13_40532306_40532606	0.22	ENSG00000212553	.	101092	0.08
chr7_138781161_138781312	0.22	ZC3HAV1	zinc finger CCCH-type, antiviral 1	12864	0.2
chr1_198652510_198652661	0.22	RP11-553K8.5		16395	0.24
chr9_95709767_95710401	0.22	FGD3	FYVE, RhoGEF and PH domain containing 3	351	0.89
chr5_156618387_156618538	0.22	ITK	IL2-inducible T-cell kinase	10625	0.13
chr22_40299734_40299885	0.22	GRAP2	GRB2-related adaptor protein 2	2696	0.25
chr11_60743733_60743884	0.21	CD6	CD6 molecule	4470	0.13
chr2_55986068_55986219	0.21	PNPT1	polyribonucleotide nucleotidyltransferase 1	65098	0.11
chr3_186745077_186745229	0.21	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	1882	0.42
chr20_41945805_41945956	0.21	ENSG00000252193	.	12685	0.22
chr5_118664484_118664635	0.21	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	4311	0.24
chr12_82826657_82826808	0.21	METTL25	methyltransferase like 25	33594	0.21
chr5_76112526_76112677	0.21	F2RL1	coagulation factor II (thrombin) receptor-like 1	2157	0.27
chr21_25260128_25260279	0.21	ENSG00000199698	.	455601	0.01
chr5_156608669_156608858	0.21	ITK	IL2-inducible T-cell kinase	926	0.47
chr6_116599180_116599459	0.21	TSPYL1	TSPY-like 1	1747	0.27
chr6_139466066_139466217	0.21	HECA	headcase homolog (Drosophila)	9892	0.26
chr12_131796680_131796831	0.21	ENSG00000212251	.	12459	0.23
chr1_90097236_90097387	0.21	RP5-1007M22.2		439	0.72
chr14_99708318_99708739	0.21	AL109767.1		20757	0.2
chr17_74964898_74965186	0.21	ENSG00000267568	.	137	0.97
chrY_2804248_2804778	0.21	ZFY	zinc finger protein, Y-linked	967	0.67
chr10_88149204_88149554	0.21	GRID1	glutamate receptor, ionotropic, delta 1	23144	0.2
chr14_22959148_22959353	0.21	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	3079	0.14
chr2_119067427_119067713	0.21	INSIG2	insulin induced gene 2	221520	0.02
chr1_64709067_64709297	0.21	UBE2U	ubiquitin-conjugating enzyme E2U (putative)	22635	0.23
chr4_40209794_40209945	0.21	RHOH	ras homolog family member H	7905	0.22
chr6_70525806_70525957	0.21	LMBRD1	LMBR1 domain containing 1	18878	0.25
chr1_25889724_25889930	0.21	LDLRAP1	low density lipoprotein receptor adaptor protein 1	19756	0.18
chr1_156785806_156786457	0.20	SH2D2A	SH2 domain containing 2A	495	0.51
chr16_84793452_84793603	0.20	USP10	ubiquitin specific peptidase 10	8344	0.22
chr22_50908966_50909262	0.20	SBF1	SET binding factor 1	4257	0.1
chrX_49969678_49969829	0.20	CCNB3	cyclin B3	157	0.95
chr6_90793537_90793688	0.20	ENSG00000222078	.	82387	0.09
chr3_60048337_60048488	0.20	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	90829	0.1
chr2_40852910_40853149	0.20	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	14836	0.31
chr19_43032769_43032982	0.20	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	214	0.93
chr18_56534214_56534481	0.20	ZNF532	zinc finger protein 532	1561	0.4
chr2_181991184_181991335	0.20	UBE2E3	ubiquitin-conjugating enzyme E2E 3	144509	0.05
chr22_30702592_30702944	0.20	TBC1D10A	TBC1 domain family, member 10A	1111	0.32
chr15_94040758_94040909	0.20	ENSG00000212063	.	211281	0.02
chr10_46075820_46076565	0.20	MARCH8	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	13747	0.25
chr4_36245078_36245884	0.20	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chrX_78200973_78201449	0.20	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	293	0.95
chr3_71177743_71177975	0.20	FOXP1	forkhead box P1	1885	0.5
chr20_49134113_49134959	0.20	PTPN1	protein tyrosine phosphatase, non-receptor type 1	7616	0.17
chr9_139990924_139991075	0.20	ENSG00000199411	.	2202	0.1
chrY_15815919_15816489	0.20	TMSB4Y	thymosin beta 4, Y-linked	757	0.72
chr1_169679248_169679951	0.20	SELL	selectin L	1240	0.48
chr10_14882651_14882802	0.20	CDNF	cerebral dopamine neurotrophic factor	2152	0.26
chr10_2859821_2859972	0.20	PFKP	phosphofructokinase, platelet	248629	0.02
chr10_33425652_33425891	0.20	ENSG00000263576	.	38207	0.16
chr13_99728156_99728379	0.19	DOCK9	dedicator of cytokinesis 9	10393	0.2
chr6_167526422_167526606	0.19	CCR6	chemokine (C-C motif) receptor 6	1219	0.48
chr15_60881660_60881911	0.19	RORA	RAR-related orphan receptor A	2955	0.3
chr12_68930348_68930499	0.19	RAP1B	RAP1B, member of RAS oncogene family	74196	0.1
chr21_15917916_15918619	0.19	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr1_875795_876285	0.19	SAMD11	sterile alpha motif domain containing 11	1385	0.25
chr12_92532725_92532888	0.19	C12orf79	chromosome 12 open reading frame 79	2009	0.29
chr15_86167470_86167715	0.19	RP11-815J21.3		3328	0.19
chrX_107293796_107293947	0.19	VSIG1	V-set and immunoglobulin domain containing 1	5576	0.21
chr1_223900690_223901533	0.19	CAPN2	calpain 2, (m/II) large subunit	1077	0.55
chr11_8228040_8228278	0.19	RIC3	RIC3 acetylcholine receptor chaperone	37557	0.16
chr16_29106297_29106839	0.19	CTB-134H23.3		12198	0.13
chr1_209946189_209946340	0.19	TRAF3IP3	TRAF3 interacting protein 3	4304	0.16
chr6_138192975_138193775	0.19	RP11-356I2.4		4005	0.25
chr5_87972631_87972782	0.19	CTC-467M3.1		670	0.71
chr12_112431759_112432046	0.19	TMEM116	transmembrane protein 116	11887	0.16
chr3_138213629_138213780	0.19	CEP70	centrosomal protein 70kDa	5318	0.27
chr13_45991538_45991858	0.19	SLC25A30	solute carrier family 25, member 30	811	0.6
chr9_134603422_134603972	0.19	ENSG00000240853	.	2843	0.28
chr12_866633_866784	0.19	WNK1	WNK lysine deficient protein kinase 1	3976	0.25
chr3_33841685_33842232	0.18	PDCD6IP	programmed cell death 6 interacting protein	1843	0.49
chr6_159071973_159072124	0.18	SYTL3	synaptotagmin-like 3	1002	0.53
chr2_24125229_24125380	0.18	ATAD2B	ATPase family, AAA domain containing 2B	24631	0.17
chr8_66742389_66742540	0.18	PDE7A	phosphodiesterase 7A	8519	0.29

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX1_GSX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.2	0.6	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.4	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.3	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.6	GO:0002837	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.1	0.2	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.2	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.5	GO:0015671	oxygen transport(GO:0015671)
0.1	0.3	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.3	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.2	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.1	0.2	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.1	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.5	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.3	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.2	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.2	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0050856	regulation of T cell receptor signaling pathway(GO:0050856)
0.0	0.2	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0072109	glomerular mesangium development(GO:0072109)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.2	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0048865	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.1	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.1	GO:0055026	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.2	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.1	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0072498	embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0	0.1	GO:0042541	hemoglobin biosynthetic process(GO:0042541)
0.0	0.1	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	1.0	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0021819	cerebral cortex radial glia guided migration(GO:0021801) layer formation in cerebral cortex(GO:0021819) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.2	GO:0030260	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0060134	prepulse inhibition(GO:0060134)
0.0	0.4	GO:1901185	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.0	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.0	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.1	GO:0007616	long-term memory(GO:0007616)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.3	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.0	GO:0003170	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.0	GO:2000053	Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.0	GO:0060177	regulation of angiotensin levels in blood(GO:0002002) regulation of angiotensin metabolic process(GO:0060177)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.0	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0046541	saliva secretion(GO:0046541)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.0	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.0	GO:0060463	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.0	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.6	GO:0042101	T cell receptor complex(GO:0042101)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.3	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.7	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	1.2	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.5	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	1.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.6	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.0	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.0	GO:0015421	oligopeptide-transporting ATPase activity(GO:0015421) peptide-transporting ATPase activity(GO:0015440)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.0	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0019894	kinesin binding(GO:0019894)
0.0	0.3	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.1	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.8	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.4	PID CD40 PATHWAY	CD40/CD40L signaling
0.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.5	PID IL2 1PATHWAY	IL2-mediated signaling events
0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.5	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.5	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	PID EPO PATHWAY	EPO signaling pathway
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	PID S1P S1P3 PATHWAY	S1P3 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	1.9	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.0	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.5	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.6	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	1.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.4	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0	0.0	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.0	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.4	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.0	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.1	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.0	REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA

Results for VAX1_GSX2

Z-value: 0.66

Motif logo

Transcription factors associated with VAX1_GSX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the VAX1_GSX2 motif across conditions

Conditions sorted by the z-value of the VAX1_GSX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX1_GSX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: