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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for VENTX

Z-value: 0.49

Motif logo

Transcription factors associated with VENTX

Gene Symbol	Gene ID	Gene Info
VENTX Ensembl NCBI GeneCards UniProt	ENSG00000151650.7	VENTX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
VENTX	chr10_135050883_135051034	50	0.956989	0.86	3.1e-03	Click!
VENTX	chr10_135050086_135050399	666	0.567785	0.63	7.1e-02	Click!
VENTX	chr10_135055376_135055527	4543	0.126368	0.51	1.6e-01	Click!
VENTX	chr10_135054758_135055166	4054	0.132122	-0.29	4.4e-01	Click!
VENTX	chr10_135050414_135050565	419	0.744992	0.23	5.5e-01	Click!

Activity of the VENTX motif across conditions

Conditions sorted by the z-value of the VENTX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_180523773_180523999	0.17	OR2V1	olfactory receptor, family 2, subfamily V, member 1	28418	0.12
chr5_180529470_180529621	0.16	OR2V1	olfactory receptor, family 2, subfamily V, member 1	22759	0.13
chr8_18870397_18870669	0.16	PSD3	pleckstrin and Sec7 domain containing 3	663	0.74
chr1_210412971_210413268	0.14	SERTAD4-AS1	SERTAD4 antisense RNA 1	5727	0.24
chr10_62332469_62332822	0.13	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	224	0.97
chr2_148394040_148394242	0.13	ENSG00000253083	.	76982	0.1
chr1_112604147_112604298	0.12	KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	72445	0.11
chr6_14671059_14671210	0.12	ENSG00000206960	.	24368	0.28
chr9_13278507_13279169	0.11	RP11-272P10.2		348	0.67
chr13_108520152_108520684	0.11	FAM155A	family with sequence similarity 155, member A	1335	0.55
chr2_188418561_188419245	0.11	AC007319.1		27	0.69
chr15_47476270_47477144	0.10	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	409	0.87
chr7_25901481_25901888	0.10	ENSG00000199085	.	87922	0.1
chr11_27743805_27744092	0.10	BDNF	brain-derived neurotrophic factor	343	0.92
chr10_114714851_114715858	0.10	RP11-57H14.2		3720	0.26
chr14_53275157_53275308	0.10	GNPNAT1	glucosamine-phosphate N-acetyltransferase 1	16846	0.16
chr16_62068318_62068835	0.10	CDH8	cadherin 8, type 2	462	0.9
chr18_53253101_53253291	0.10	TCF4	transcription factor 4	1	0.99
chr3_148716623_148716961	0.09	GYG1	glycogenin 1	6634	0.21
chr19_56332953_56333104	0.09	NLRP11	NLR family, pyrin domain containing 11	3425	0.16
chr6_123110919_123111172	0.09	SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A	574	0.77
chr17_59534634_59534785	0.09	TBX4	T-box 4	902	0.53
chr6_133563559_133563958	0.09	EYA4	eyes absent homolog 4 (Drosophila)	989	0.7
chr3_100118869_100119020	0.09	LNP1	leukemia NUP98 fusion partner 1	1093	0.41
chr4_105982764_105983024	0.09	ENSG00000252136	.	44250	0.17
chr13_107124235_107124715	0.09	EFNB2	ephrin-B2	62987	0.14
chr10_52750817_52751095	0.08	PRKG1	protein kinase, cGMP-dependent, type I	11	0.99
chr11_57077918_57078147	0.08	TNKS1BP1	tankyrase 1 binding protein 1, 182kDa	11639	0.11
chr1_30417491_30417642	0.08	ENSG00000222787	.	59817	0.17
chr11_10661867_10662018	0.08	MRVI1	murine retrovirus integration site 1 homolog	11790	0.19
chr11_57546160_57546525	0.08	CTNND1	catenin (cadherin-associated protein), delta 1	2733	0.22
chr10_96161850_96162001	0.08	TBC1D12	TBC1 domain family, member 12	336	0.91
chr2_182760406_182760853	0.08	SSFA2	sperm specific antigen 2	3706	0.25
chr20_59830411_59830643	0.08	CDH4	cadherin 4, type 1, R-cadherin (retinal)	3045	0.42
chr10_126846286_126846503	0.08	CTBP2	C-terminal binding protein 2	891	0.72
chr13_67804057_67805835	0.08	PCDH9	protocadherin 9	478	0.9
chr18_33164100_33164377	0.08	GALNT1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	2534	0.31
chr19_1154555_1155129	0.08	SBNO2	strawberry notch homolog 2 (Drosophila)	293	0.85
chr1_214722890_214723041	0.08	PTPN14	protein tyrosine phosphatase, non-receptor type 14	1601	0.51
chr8_126322078_126322527	0.08	ENSG00000242170	.	39456	0.16
chr8_42356526_42357223	0.08	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	1887	0.34
chr2_119989374_119989591	0.08	STEAP3	STEAP family member 3, metalloreductase	8053	0.2
chr4_57984994_57985389	0.08	IGFBP7	insulin-like growth factor binding protein 7	8640	0.18
chr22_41178472_41178623	0.08	SLC25A17	solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17	2349	0.27
chr22_46476561_46476775	0.07	FLJ27365	hsa-mir-4763	476	0.66
chr22_46471692_46472277	0.07	FLJ27365	hsa-mir-4763	4208	0.11
chr14_34401158_34401309	0.07	EGLN3	egl-9 family hypoxia-inducible factor 3	18799	0.24
chr9_39816869_39817104	0.07	SPATA31A2	SPATA31 subfamily A, member 2	67989	0.13
chr17_12645469_12645648	0.07	MYOCD	myocardin	2110	0.29
chr14_27066054_27066282	0.07	NOVA1	neuro-oncological ventral antigen 1	120	0.95
chr10_29010987_29011704	0.07	ENSG00000201001	.	38387	0.14
chr9_39287616_39287852	0.07	CNTNAP3	contactin associated protein-like 3	358	0.92
chr15_67334428_67334662	0.07	SMAD3	SMAD family member 3	21556	0.25
chr9_27109543_27109972	0.07	TEK	TEK tyrosine kinase, endothelial	306	0.93
chr1_8433877_8434267	0.07	RERE	arginine-glutamic acid dipeptide (RE) repeats	9174	0.19
chr5_139721479_139721638	0.07	HBEGF	heparin-binding EGF-like growth factor	4630	0.14
chr4_77115816_77116180	0.07	SCARB2	scavenger receptor class B, member 2	18758	0.15
chr5_16935133_16935934	0.07	MYO10	myosin X	514	0.81
chr9_22239273_22239447	0.07	CDKN2B-AS1	CDKN2B antisense RNA 1	125683	0.06
chr21_27540114_27540265	0.07	APP	amyloid beta (A4) precursor protein	2783	0.28
chr4_43019583_43019734	0.07	GRXCR1	glutaredoxin, cysteine rich 1	124374	0.06
chr4_158143735_158144020	0.07	GRIA2	glutamate receptor, ionotropic, AMPA 2	1059	0.6
chr9_43685064_43685767	0.07	CNTNAP3B	contactin associated protein-like 3B	505	0.86
chrX_40048176_40048340	0.07	BCOR	BCL6 corepressor	11676	0.29
chr1_230223080_230223231	0.07	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	20137	0.23
chr12_32739224_32739514	0.07	FGD4	FYVE, RhoGEF and PH domain containing 4	12091	0.26
chr4_83810146_83810528	0.07	SEC31A	SEC31 homolog A (S. cerevisiae)	1834	0.28
chr1_95267376_95267764	0.07	SLC44A3	solute carrier family 44, member 3	18328	0.2
chr6_42192493_42192832	0.07	MRPS10	mitochondrial ribosomal protein S10	7059	0.19
chr2_9389435_9389677	0.07	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	42662	0.19
chr21_16433048_16433989	0.07	NRIP1	nuclear receptor interacting protein 1	3608	0.34
chr1_108479731_108479983	0.07	VAV3-AS1	VAV3 antisense RNA 1	27208	0.19
chr18_9016920_9017224	0.07	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	85556	0.08
chr3_121450033_121450184	0.07	GOLGB1	golgin B1	1311	0.47
chr18_59659824_59660127	0.07	RNF152	ring finger protein 152	98511	0.08
chr14_23289433_23289584	0.07	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	488	0.61
chr9_41432727_41433091	0.06	SPATA31A5	SPATA31 subfamily A, member 5	67770	0.13
chr5_14184300_14184719	0.06	TRIO	trio Rho guanine nucleotide exchange factor	602	0.86
chr1_95005421_95005705	0.06	F3	coagulation factor III (thromboplastin, tissue factor)	1630	0.52
chr4_88817282_88817552	0.06	MEPE	matrix extracellular phosphoglycoprotein	63278	0.1
chr1_85960933_85961288	0.06	DDAH1	dimethylarginine dimethylaminohydrolase 1	30283	0.18
chr17_45197869_45198099	0.06	ENSG00000221016	.	2116	0.25
chr16_4900453_4900687	0.06	UBN1	ubinuclein 1	1646	0.27
chr1_179110770_179111258	0.06	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	1165	0.52
chr17_37786060_37786211	0.06	PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	1384	0.29
chr10_96163775_96164021	0.06	TBC1D12	TBC1 domain family, member 12	1637	0.43
chr14_65170645_65170998	0.06	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	1	0.98
chr4_139160727_139161292	0.06	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	2494	0.42
chr6_101846988_101847139	0.06	GRIK2	glutamate receptor, ionotropic, kainate 2	91	0.99
chr16_13401641_13401792	0.06	AC003009.1		24724	0.26
chr9_40632604_40633916	0.06	SPATA31A3	SPATA31 subfamily A, member 3	67031	0.14
chrX_112573298_112573449	0.06	ENSG00000238811	.	329017	0.01
chr9_110310779_110311295	0.06	KLF4	Kruppel-like factor 4 (gut)	58274	0.13
chr4_60684263_60684575	0.06	ENSG00000201676	.	14474	0.24
chr2_43134028_43134374	0.06	HAAO	3-hydroxyanthranilate 3,4-dioxygenase	114469	0.06
chr12_54369798_54369949	0.06	HOTAIR	HOX transcript antisense RNA	1133	0.21
chr20_61049732_61049883	0.06	GATA5	GATA binding protein 5	1219	0.43
chr8_94935365_94935516	0.06	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	3333	0.24
chr9_21677527_21678485	0.06	ENSG00000244230	.	21307	0.21
chr2_185462344_185462621	0.06	ZNF804A	zinc finger protein 804A	611	0.86
chr19_30792538_30792689	0.06	ZNF536	zinc finger protein 536	70706	0.12
chr3_49447935_49448923	0.06	RHOA	ras homolog family member A	932	0.32
chr18_42595960_42596214	0.06	ENSG00000265957	.	45956	0.2
chr1_98514169_98514606	0.06	ENSG00000225206	.	2660	0.42
chr4_129731963_129732326	0.06	JADE1	jade family PHD finger 1	299	0.94
chr3_128914407_128914640	0.06	CNBP	CCHC-type zinc finger, nucleic acid binding protein	11758	0.14
chr19_42712554_42712705	0.06	DEDD2	death effector domain containing 2	9192	0.09
chr4_30726767_30727321	0.06	PCDH7	protocadherin 7	3067	0.38
chr6_11795100_11795449	0.06	ADTRP	androgen-dependent TFPI-regulating protein	12005	0.28
chr17_70119242_70119466	0.06	SOX9	SRY (sex determining region Y)-box 9	2193	0.46
chr1_246034788_246034939	0.06	RP11-83A16.1		161990	0.04
chr4_90410428_90410579	0.06	RP11-115D19.1		62004	0.15
chr11_12132484_12132785	0.06	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	496	0.87
chr18_24237635_24237786	0.06	KCTD1	potassium channel tetramerization domain containing 1	345	0.86
chr9_65576390_65577630	0.06	SPATA31A7	SPATA31 subfamily A, member 7	67400	0.15
chrX_105065880_105066259	0.06	NRK	Nik related kinase	467	0.87
chr15_101419100_101419461	0.06	ALDH1A3	aldehyde dehydrogenase 1 family, member A3	301	0.92
chr13_30415572_30415723	0.06	UBL3	ubiquitin-like 3	9174	0.3
chr3_170527527_170527678	0.06	ENSG00000222411	.	32359	0.19
chr6_4370257_4370408	0.05	ENSG00000201185	.	57865	0.15
chr1_15587858_15588078	0.05	FHAD1	forkhead-associated (FHA) phosphopeptide binding domain 1	9687	0.21
chr2_66663569_66663965	0.05	MEIS1	Meis homeobox 1	758	0.57
chr14_29859562_29859789	0.05	ENSG00000257522	.	11813	0.29
chr9_89952337_89952906	0.05	ENSG00000212421	.	77256	0.11
chr2_182758331_182758678	0.05	SSFA2	sperm specific antigen 2	1581	0.37
chr7_28725956_28726399	0.05	CREB5	cAMP responsive element binding protein 5	579	0.86
chr12_18841597_18841748	0.05	PLCZ1	phospholipase C, zeta 1	6299	0.25
chr12_89744161_89744444	0.05	DUSP6	dual specificity phosphatase 6	646	0.8
chr10_4100667_4100818	0.05	KLF6	Kruppel-like factor 6	273269	0.02
chr17_32571233_32571384	0.05	CCL2	chemokine (C-C motif) ligand 2	10996	0.13
chr14_31022770_31022975	0.05	G2E3	G2/M-phase specific E3 ubiquitin protein ligase	5457	0.25
chr2_237073495_237073728	0.05	AC079135.1		2479	0.22
chr1_46714502_46714653	0.05	RAD54L	RAD54-like (S. cerevisiae)	1136	0.42
chr7_113054663_113054814	0.05	TSRM	Uncharacterized protein; Zinc finger domain-related protein TSRM	36389	0.24
chr2_106593474_106593625	0.05	C2orf40	chromosome 2 open reading frame 40	86201	0.09
chr22_50730996_50731325	0.05	PLXNB2	plexin B2	3170	0.12
chrX_81845191_81845342	0.05	ENSG00000202183	.	28616	0.27
chr2_101620301_101620452	0.05	RPL31	ribosomal protein L31	1175	0.38
chr9_105966807_105967305	0.05	CYLC2	cylicin, basic protein of sperm head cytoskeleton 2	209430	0.03
chr10_8105207_8105358	0.05	GATA3	GATA binding protein 3	8513	0.32
chr8_12976784_12976935	0.05	DLC1	deleted in liver cancer 1	3106	0.31
chr1_180470891_180472111	0.05	ACBD6	acyl-CoA binding domain containing 6	588	0.75
chr12_10868992_10869331	0.05	YBX3	Y box binding protein 3	6745	0.18
chr13_92456795_92456946	0.05	ENSG00000252508	.	255227	0.02
chr14_70168154_70168305	0.05	SRSF5	serine/arginine-rich splicing factor 5	25388	0.21
chr5_98111445_98111873	0.05	RGMB	repulsive guidance molecule family member b	2320	0.3
chr5_121517177_121517861	0.05	CTC-441N14.1		25809	0.17
chr3_179168052_179168298	0.05	GNB4	guanine nucleotide binding protein (G protein), beta polypeptide 4	758	0.66
chr18_59619337_59619488	0.05	RNF152	ring finger protein 152	57948	0.16
chrX_133500265_133500416	0.05	PHF6	PHD finger protein 6	6943	0.21
chr11_69454777_69455129	0.05	CCND1	cyclin D1	902	0.63
chr1_155971887_155972038	0.05	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	4899	0.11
chr1_217542715_217542866	0.05	RP11-361K17.2		122527	0.06
chr8_17015787_17015938	0.05	ZDHHC2	zinc finger, DHHC-type containing 2	919	0.67
chr8_89289368_89289519	0.05	RP11-586K2.1		49622	0.16
chr12_109901272_109901510	0.05	KCTD10	potassium channel tetramerization domain containing 10	3191	0.21
chr9_80499174_80499388	0.05	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	61366	0.15
chr7_54911574_54911725	0.05	ENSG00000252054	.	21862	0.24
chr3_100785098_100785499	0.05	ABI3BP	ABI family, member 3 (NESH) binding protein	72939	0.11
chr2_8260069_8260430	0.05	ENSG00000221255	.	543277	0.0
chr5_147836900_147837051	0.05	CTD-2283N19.1		26605	0.18
chr17_29818089_29818240	0.05	RAB11FIP4	RAB11 family interacting protein 4 (class II)	3038	0.19
chr2_65009133_65009284	0.05	ENSG00000253082	.	5970	0.22
chr1_224840379_224840592	0.05	CNIH3	cornichon family AMPA receptor auxiliary protein 3	36490	0.15
chr10_12109593_12109744	0.05	DHTKD1	dehydrogenase E1 and transketolase domain containing 1	1303	0.41
chr2_161237855_161238493	0.05	ENSG00000252465	.	15305	0.2
chr12_42875750_42875901	0.05	PRICKLE1	prickle homolog 1 (Drosophila)	1049	0.48
chr22_19073564_19073715	0.05	AC004471.9		35403	0.09
chr6_106830032_106830183	0.05	RP11-404H14.1		22515	0.15
chr14_85998039_85998552	0.05	FLRT2	fibronectin leucine rich transmembrane protein 2	1723	0.42
chr10_61624710_61624861	0.05	CCDC6	coiled-coil domain containing 6	41629	0.19
chr4_117414362_117414513	0.05	MTRNR2L13	MT-RNR2-like 13 (pseudogene)	194421	0.03
chr6_108883421_108883945	0.05	FOXO3	forkhead box O3	1614	0.53
chr11_72452051_72452202	0.05	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	11322	0.12
chr15_99449448_99449599	0.05	RP11-654A16.1		12759	0.21
chr10_17256481_17257128	0.05	VIM-AS1	VIM antisense RNA 1	12093	0.15
chr17_41668751_41668949	0.05	ETV4	ets variant 4	11862	0.16
chr14_86047408_86047594	0.05	FLRT2	fibronectin leucine rich transmembrane protein 2	50929	0.16
chr11_111810760_111811015	0.05	DIXDC1	DIX domain containing 1	2736	0.15
chr2_197089791_197089942	0.05	ENSG00000239161	.	9820	0.19
chr7_12728576_12729094	0.05	ARL4A	ADP-ribosylation factor-like 4A	1575	0.44
chr11_131847622_131847821	0.05	RP11-697E14.2		6834	0.28
chr6_126890888_126891039	0.05	ENSG00000201613	.	20576	0.27
chr16_79693058_79693209	0.05	ENSG00000221330	.	10501	0.29
chr5_88178054_88178448	0.05	MEF2C	myocyte enhancer factor 2C	713	0.52
chr8_10587151_10587560	0.05	CTD-2135J3.3		267	0.76
chr3_114790766_114791082	0.05	ZBTB20	zinc finger and BTB domain containing 20	702	0.82
chr6_168079333_168079613	0.05	AL009178.1	Uncharacterized protein; cDNA FLJ43200 fis, clone FEBRA2007793	116737	0.06
chr5_178202811_178202962	0.05	AACSP1	acetoacetyl-CoA synthetase pseudogene 1	21726	0.18
chr12_58705170_58705321	0.05	RP11-362K2.2	Protein LOC100506869	232662	0.02
chr1_200558260_200558411	0.05	KIF14	kinesin family member 14	31527	0.2
chr3_69870376_69870665	0.05	MITF	microphthalmia-associated transcription factor	44843	0.17
chr11_63775179_63775448	0.05	OTUB1	OTU domain, ubiquitin aldehyde binding 1	20999	0.1
chr1_226220312_226220463	0.05	H3F3A	H3 histone, family 3A	29165	0.13
chr20_10521227_10521501	0.05	SLX4IP	SLX4 interacting protein	105413	0.06
chr5_95584344_95584495	0.05	ENSG00000206997	.	38488	0.2
chr6_7547044_7547195	0.05	DSP	desmoplakin	5269	0.22
chr6_136570446_136570737	0.05	MTFR2	mitochondrial fission regulator 2	841	0.63
chr4_157880787_157880981	0.05	PDGFC	platelet derived growth factor C	11171	0.22
chr5_81064717_81065068	0.05	SSBP2	single-stranded DNA binding protein 2	17820	0.28

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of VENTX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.1	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	GO:0014824	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	GO:0070141	response to UV-A(GO:0070141)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)