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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for VSX1

Z-value: 0.85

Motif logo

Transcription factors associated with VSX1

Gene Symbol	Gene ID	Gene Info
VSX1 Ensembl NCBI GeneCards UniProt	ENSG00000100987.10	VSX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
VSX1	chr20_25071710_25071861	8789	0.209651	-0.47	2.0e-01	Click!
VSX1	chr20_25064794_25064945	1873	0.363721	-0.45	2.3e-01	Click!
VSX1	chr20_25064515_25064666	1594	0.408889	-0.23	5.5e-01	Click!
VSX1	chr20_25064050_25064221	1139	0.524864	0.22	5.6e-01	Click!
VSX1	chr20_25064259_25064410	1338	0.466158	0.05	9.1e-01	Click!

Activity of the VSX1 motif across conditions

Conditions sorted by the z-value of the VSX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_12849556_12849989	0.42	RP11-47J17.3		4558	0.23
chr16_62022994_62023145	0.38	CDH8	cadherin 8, type 2	32437	0.22
chr3_112356169_112356393	0.37	CCDC80	coiled-coil domain containing 80	663	0.77
chr15_96881050_96881298	0.31	ENSG00000222651	.	4684	0.17
chr2_217235630_217236249	0.31	MARCH4	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	811	0.59
chrX_34671991_34672311	0.30	TMEM47	transmembrane protein 47	3254	0.41
chr10_25008347_25008498	0.30	ARHGAP21	Rho GTPase activating protein 21	2373	0.41
chr17_66700653_66700804	0.28	ENSG00000263690	.	61972	0.13
chr6_74226468_74226678	0.28	EEF1A1	eukaryotic translation elongation factor 1 alpha 1	4168	0.13
chr15_96878465_96878729	0.28	ENSG00000222651	.	2107	0.24
chr1_236046389_236046555	0.28	LYST	lysosomal trafficking regulator	400	0.83
chr1_196577911_196578299	0.27	KCNT2	potassium channel, subfamily T, member 2	250	0.94
chr6_111984874_111985025	0.27	ENSG00000239015	.	17319	0.19
chr2_189158529_189158680	0.25	GULP1	GULP, engulfment adaptor PTB domain containing 1	59	0.98
chr3_173266211_173266362	0.25	NLGN1	neuroligin 1	36059	0.24
chr6_127780261_127780437	0.25	KIAA0408	KIAA0408	161	0.97
chr1_164532131_164532342	0.25	PBX1	pre-B-cell leukemia homeobox 1	194	0.97
chr1_245461989_245462162	0.25	RP11-62I21.1		64272	0.12
chr11_31831142_31831293	0.24	PAX6	paired box 6	636	0.72
chr11_106239153_106239583	0.24	RP11-680E19.1		104326	0.08
chr1_99126586_99127126	0.24	SNX7	sorting nexin 7	380	0.93
chr10_119564055_119564206	0.24	RP11-354M20.3		212868	0.02
chr14_52534801_52535890	0.24	NID2	nidogen 2 (osteonidogen)	367	0.89
chr12_18622010_18622161	0.24	PIK3C2G	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	187107	0.03
chr4_71997150_71997347	0.24	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	55755	0.16
chr9_100069620_100070257	0.24	CCDC180	coiled-coil domain containing 180	3	0.98
chr3_79067433_79067887	0.24	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	34	0.99
chr15_101261674_101262051	0.24	ENSG00000212306	.	83294	0.08
chr8_121137253_121137925	0.24	COL14A1	collagen, type XIV, alpha 1	237	0.96
chr20_56749874_56750278	0.23	C20orf85	chromosome 20 open reading frame 85	24116	0.19
chr8_37350646_37351319	0.23	RP11-150O12.6		23557	0.24
chr5_15501266_15501663	0.23	FBXL7	F-box and leucine-rich repeat protein 7	83	0.99
chr6_85256272_85256423	0.23	RP11-132M7.3		142796	0.05
chr4_123776122_123776354	0.22	ENSG00000253069	.	28069	0.14
chr5_110429004_110429186	0.22	WDR36	WD repeat domain 36	1076	0.41
chr11_124733143_124733554	0.22	ROBO3	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1934	0.2
chr19_9473504_9474272	0.22	ZNF177	zinc finger protein 177	181	0.93
chr8_89336204_89336358	0.22	RP11-586K2.1		2784	0.3
chr17_13503089_13503240	0.22	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	2080	0.42
chr1_76757094_76757245	0.22	ST6GALNAC3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	216765	0.02
chr19_2185882_2186045	0.21	DOT1L	DOT1-like histone H3K79 methyltransferase	21779	0.09
chr1_214723042_214723197	0.21	PTPN14	protein tyrosine phosphatase, non-receptor type 14	1447	0.54
chr18_65188257_65188408	0.21	DSEL	dermatan sulfate epimerase-like	4115	0.29
chr5_32803819_32803970	0.21	AC026703.1		14949	0.22
chr14_24838154_24838623	0.21	NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	15	0.95
chr16_86603613_86603777	0.21	RP11-463O9.5		2328	0.23
chr1_162603392_162603656	0.21	DDR2	discoidin domain receptor tyrosine kinase 2	1264	0.48
chr5_16916952_16917142	0.21	MYO10	myosin X	411	0.87
chr12_19358284_19358561	0.21	PLEKHA5	pleckstrin homology domain containing, family A member 5	163	0.96
chr5_16713576_16713796	0.21	MYO10	myosin X	24810	0.21
chr11_8831505_8831934	0.20	ST5	suppression of tumorigenicity 5	477	0.76
chr8_42063953_42065062	0.20	PLAT	plasminogen activator, tissue	576	0.71
chr18_52721804_52722049	0.20	ENSG00000264804	.	53297	0.15
chr13_24146066_24146217	0.20	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	1338	0.59
chr12_65997242_65997414	0.20	HMGA2	high mobility group AT-hook 2	220583	0.02
chr21_32591500_32591929	0.20	TIAM1	T-cell lymphoma invasion and metastasis 1	57369	0.16
chr2_40098959_40099110	0.20	SLC8A1-AS1	SLC8A1 antisense RNA 1	47799	0.18
chr17_45331851_45332126	0.20	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	725	0.57
chr6_53928552_53928746	0.20	MLIP-AS1	MLIP antisense RNA 1	15875	0.2
chr1_118238331_118238482	0.20	ENSG00000212266	.	7042	0.28
chr2_157659750_157659995	0.20	ENSG00000263848	.	211897	0.02
chr2_74606600_74607395	0.20	DCTN1	dynactin 1	413	0.73
chr2_100297290_100297441	0.20	AFF3	AF4/FMR2 family, member 3	102533	0.08
chr13_95003800_95004010	0.20	ENSG00000212057	.	113739	0.06
chr13_96295623_96295774	0.20	DZIP1	DAZ interacting zinc finger protein 1	181	0.96
chr13_24044512_24044663	0.19	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	36746	0.21
chr5_111090218_111090459	0.19	NREP	neuronal regeneration related protein	1610	0.42
chr2_144692978_144693129	0.19	AC016910.1		1587	0.49
chr13_33803610_33803839	0.19	STARD13	StAR-related lipid transfer (START) domain containing 13	23581	0.2
chr18_60278197_60278407	0.19	ENSG00000243549	.	39532	0.17
chr15_96886136_96886425	0.19	ENSG00000222651	.	9790	0.16
chr13_111768316_111768682	0.19	ARHGEF7-AS2	ARHGEF7 antisense RNA 2	474	0.54
chr4_81198150_81198317	0.19	FGF5	fibroblast growth factor 5	10440	0.25
chr12_44131589_44131740	0.19	RP11-210N13.1		968	0.56
chr1_182932139_182932350	0.19	ENSG00000264768	.	3534	0.19
chr1_107682797_107683388	0.19	NTNG1	netrin G1	350	0.93
chr6_52440366_52440800	0.19	TRAM2	translocation associated membrane protein 2	1130	0.59
chr11_57530814_57530965	0.19	CTNND1	catenin (cadherin-associated protein), delta 1	436	0.77
chr17_47547430_47548013	0.19	NGFR	nerve growth factor receptor	24934	0.13
chr3_106060605_106060757	0.18	ENSG00000200610	.	174063	0.04
chr11_111849006_111849202	0.18	DIXDC1	DIX domain containing 1	1071	0.39
chr12_22059820_22060034	0.18	ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	3985	0.3
chr7_93552303_93552503	0.18	GNG11	guanine nucleotide binding protein (G protein), gamma 11	1392	0.38
chr9_98188423_98189086	0.18	PTCH1	patched 1	54013	0.12
chr4_187025490_187026623	0.18	FAM149A	family with sequence similarity 149, member A	175	0.94
chr15_39876247_39876621	0.18	THBS1	thrombospondin 1	3140	0.25
chr10_18629419_18629841	0.18	CACNB2	calcium channel, voltage-dependent, beta 2 subunit	36	0.99
chr4_52903402_52903553	0.18	SGCB	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)	948	0.59
chr15_57124208_57124359	0.18	ZNF280D	zinc finger protein 280D	86486	0.09
chr12_105711891_105712042	0.18	RP11-474B16.1		8829	0.18
chr6_155475558_155475911	0.18	TIAM2	T-cell lymphoma invasion and metastasis 2	5479	0.3
chr16_56811456_56811607	0.18	NUP93	nucleoporin 93kDa	4039	0.18
chr6_84743193_84743395	0.18	MRAP2	melanocortin 2 receptor accessory protein 2	181	0.97
chr3_114343374_114343541	0.18	ZBTB20	zinc finger and BTB domain containing 20	335	0.94
chr2_101435204_101435829	0.18	NPAS2	neuronal PAS domain protein 2	1098	0.54
chr5_88129391_88129549	0.18	MEF2C	myocyte enhancer factor 2C	6495	0.28
chr5_148786412_148786563	0.18	ENSG00000208035	.	21994	0.11
chr3_63037895_63038046	0.18	CADPS	Ca++-dependent secretion activator	176916	0.03
chr4_170188382_170188561	0.18	SH3RF1	SH3 domain containing ring finger 1	2637	0.38
chr7_130606573_130606804	0.18	ENSG00000226380	.	44390	0.16
chr14_62230360_62230511	0.18	SNAPC1	small nuclear RNA activating complex, polypeptide 1, 43kDa	1360	0.55
chr9_104248314_104249564	0.17	TMEM246	transmembrane protein 246	460	0.79
chr6_148829582_148830289	0.17	ENSG00000223322	.	15441	0.29
chr4_78620774_78621041	0.17	ENSG00000221711	.	3050	0.34
chr5_121648324_121648736	0.17	SNCAIP	synuclein, alpha interacting protein	268	0.87
chr2_227834271_227834422	0.17	ENSG00000212391	.	508	0.85
chr9_4927714_4927865	0.17	ENSG00000238362	.	40308	0.13
chr2_134024891_134025042	0.17	AC010890.1		1152	0.61
chr15_60685776_60685927	0.17	ANXA2	annexin A2	2355	0.39
chr20_42544114_42544359	0.17	TOX2	TOX high mobility group box family member 2	554	0.83
chrX_135287572_135287723	0.17	FHL1	four and a half LIM domains 1	767	0.7
chr9_21688149_21688723	0.17	ENSG00000244230	.	10877	0.24
chr11_126869922_126870139	0.17	KIRREL3	kin of IRRE like 3 (Drosophila)	386	0.81
chr6_100729238_100729940	0.17	RP1-121G13.2		145405	0.05
chr13_102105579_102105898	0.17	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	720	0.77
chr12_106812256_106812407	0.17	POLR3B	polymerase (RNA) III (DNA directed) polypeptide B	36581	0.19
chr1_70406023_70406174	0.17	ENSG00000240692	.	60823	0.14
chr4_81193524_81193675	0.17	FGF5	fibroblast growth factor 5	5806	0.27
chr11_10962454_10962605	0.17	ZBED5-AS1	ZBED5 antisense RNA 1	75721	0.09
chr13_73081776_73081993	0.17	ENSG00000251715	.	47145	0.15
chr17_1914930_1915193	0.17	AC099684.1		5949	0.1
chr18_12309689_12309931	0.17	TUBB6	tubulin, beta 6 class V	1156	0.46
chr7_97361017_97361340	0.17	TAC1	tachykinin, precursor 1	42	0.99
chr15_25936715_25936881	0.17	ATP10A	ATPase, class V, type 10A	3174	0.29
chr9_94753972_94754242	0.17	ROR2	receptor tyrosine kinase-like orphan receptor 2	41663	0.19
chr4_87517094_87517245	0.17	PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	323	0.88
chr3_61546098_61546562	0.17	PTPRG	protein tyrosine phosphatase, receptor type, G	1255	0.64
chr8_22023419_22024083	0.17	BMP1	bone morphogenetic protein 1	951	0.4
chr2_201651988_201652246	0.17	ENSG00000201737	.	11810	0.12
chr17_1994078_1994475	0.17	RP11-667K14.5		1301	0.3
chr2_181388977_181389207	0.17	ENSG00000264976	.	92841	0.1
chr7_95107815_95108198	0.17	ASB4	ankyrin repeat and SOCS box containing 4	7207	0.2
chr15_86167470_86167715	0.17	RP11-815J21.3		3328	0.19
chr9_18476160_18476529	0.17	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr3_16024121_16024347	0.17	ENSG00000207815	.	108956	0.06
chr5_91941448_91941599	0.17	ENSG00000221810	.	111697	0.07
chr20_18720686_18720868	0.17	RP11-379J5.5		41424	0.15
chr5_88238815_88238969	0.17	MEF2C-AS1	MEF2C antisense RNA 1	12	0.99
chr7_70060715_70061143	0.16	AUTS2	autism susceptibility candidate 2	133196	0.06
chr3_98619314_98619465	0.16	DCBLD2	discoidin, CUB and LCCL domain containing 2	626	0.66
chr5_112033189_112033368	0.16	APC	adenomatous polyposis coli	9917	0.26
chr4_114898942_114899097	0.16	ARSJ	arylsulfatase family, member J	1133	0.61
chr4_187646786_187647042	0.16	FAT1	FAT atypical cadherin 1	962	0.7
chr15_33154166_33154394	0.16	FMN1	formin 1	26175	0.19
chr11_122597673_122598179	0.16	ENSG00000239079	.	907	0.67
chr1_93389452_93389603	0.16	FAM69A	family with sequence similarity 69, member A	37530	0.1
chr3_54277662_54277813	0.16	CACNA2D3	calcium channel, voltage-dependent, alpha 2/delta subunit 3	65914	0.14
chr10_63813819_63813970	0.16	ARID5B	AT rich interactive domain 5B (MRF1-like)	4924	0.3
chr9_137380907_137381058	0.16	RXRA	retinoid X receptor, alpha	82554	0.09
chr8_97744511_97744662	0.16	CPQ	carboxypeptidase Q	28616	0.25
chr1_45083000_45083241	0.16	RNF220	ring finger protein 220	8878	0.17
chr5_31193803_31195028	0.16	CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	558	0.85
chr7_87229218_87230455	0.16	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	336	0.9
chr9_13278507_13279169	0.16	RP11-272P10.2		348	0.67
chr10_105211471_105211777	0.16	CALHM2	calcium homeostasis modulator 2	451	0.57
chr8_41165312_41165463	0.16	SFRP1	secreted frizzled-related protein 1	878	0.57
chr20_25290950_25291163	0.16	ABHD12	abhydrolase domain containing 12	922	0.6
chr11_58874492_58875123	0.16	FAM111B	family with sequence similarity 111, member B	97	0.97
chr20_62600161_62600928	0.16	ZNF512B	zinc finger protein 512B	674	0.45
chr8_27405445_27405654	0.16	CLU	clusterin	51983	0.11
chr18_10660519_10660670	0.16	RP11-856M7.1		1336	0.48
chr11_19585849_19586032	0.16	ENSG00000265210	.	10917	0.19
chr5_71406834_71406985	0.16	MAP1B	microtubule-associated protein 1B	3596	0.33
chr8_60190630_60190781	0.16	ENSG00000206853	.	140644	0.05
chr4_114680711_114680982	0.16	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	1378	0.6
chr9_21988401_21988572	0.16	CDKN2A	cyclin-dependent kinase inhibitor 2A	5924	0.15
chr16_86353722_86353873	0.15	ENSG00000199949	.	44668	0.19
chr6_131290698_131290904	0.15	EPB41L2	erythrocyte membrane protein band 4.1-like 2	822	0.76
chr12_115135696_115136278	0.15	TBX3	T-box 3	14018	0.21
chr22_28010083_28010492	0.15	RP11-375H17.1		102181	0.08
chr6_39787271_39787422	0.15	DAAM2	dishevelled associated activator of morphogenesis 2	26552	0.21
chr5_76979205_76979356	0.15	TBCA	tubulin folding cofactor A	31862	0.19
chr21_17652021_17652264	0.15	ENSG00000201025	.	4947	0.35
chr18_53089837_53090372	0.15	TCF4	transcription factor 4	361	0.89
chr12_5294701_5295025	0.15	KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	141778	0.05
chr7_15724696_15724847	0.15	MEOX2	mesenchyme homeobox 2	1666	0.46
chr12_13500259_13500486	0.15	C12orf36	chromosome 12 open reading frame 36	28992	0.21
chr8_105235287_105235872	0.15	RIMS2	regulating synaptic membrane exocytosis 2	13	0.99
chr8_93660376_93660527	0.15	ENSG00000221172	.	12888	0.29
chr4_18595074_18595257	0.15	LCORL	ligand dependent nuclear receptor corepressor-like	571666	0.0
chr6_5498160_5498518	0.15	RP1-232P20.1		40031	0.2
chr17_38707848_38708142	0.15	CCR7	chemokine (C-C motif) receptor 7	9270	0.17
chr10_110672045_110672364	0.15	ENSG00000222436	.	28864	0.27
chr3_178787181_178787457	0.15	ZMAT3	zinc finger, matrin-type 3	2035	0.36
chr1_226285926_226286101	0.15	H3F3A	H3 histone, family 3A	34335	0.13
chr2_213401933_213402296	0.15	ERBB4	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	1139	0.66
chr7_130479581_130479757	0.15	KLF14	Kruppel-like factor 14	60781	0.12
chr6_160151501_160151652	0.15	WTAP	Wilms tumor 1 associated protein	2956	0.17
chr2_53795780_53795969	0.15	ENSG00000207456	.	1743	0.47
chr6_3750219_3750380	0.15	RP11-420L9.5		1046	0.5
chr2_188354408_188354559	0.15	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	23885	0.21
chr7_100777700_100777901	0.15	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	7421	0.1
chr1_227413559_227414076	0.15	RP11-1B20.1		47783	0.17
chr12_66220556_66220804	0.15	HMGA2	high mobility group AT-hook 2	1777	0.39
chr17_9176686_9176837	0.15	RP11-85B7.4		9730	0.26
chr1_54232654_54232848	0.15	ENSG00000201003	.	4075	0.22
chr16_82687204_82687592	0.15	CDH13	cadherin 13	26700	0.24
chr7_98734981_98735368	0.15	SMURF1	SMAD specific E3 ubiquitin protein ligase 1	6468	0.25
chr11_121966638_121966789	0.15	ENSG00000207971	.	3839	0.19
chr6_85896028_85896266	0.15	NT5E	5'-nucleotidase, ecto (CD73)	263662	0.02

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of VSX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.3	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.3	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.2	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	0.2	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1	0.1	GO:0060677	ureteric bud elongation(GO:0060677)
0.1	0.3	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.1	0.2	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.2	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1	0.3	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.1	0.2	GO:0008218	bioluminescence(GO:0008218)
0.1	0.2	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.1	0.2	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.2	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0072081	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.3	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:1904238	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0	0.1	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0	0.1	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.0	0.2	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.8	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0060992	response to fungicide(GO:0060992)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0051973	positive regulation of telomerase activity(GO:0051973)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0001840	neural plate morphogenesis(GO:0001839) neural plate development(GO:0001840)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.4	GO:0034394	protein localization to cell surface(GO:0034394)
0.0	0.1	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0090598	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:1904747	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) regulation of apoptotic process involved in morphogenesis(GO:1902337) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) regulation of apoptotic process involved in development(GO:1904748)
0.0	0.1	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.0	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.3	GO:0048538	thymus development(GO:0048538)
0.0	0.6	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0010664	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0002686	negative regulation of leukocyte migration(GO:0002686)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0007350	blastoderm segmentation(GO:0007350)
0.0	0.1	GO:0009208	GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0	0.2	GO:0001738	morphogenesis of a polarized epithelium(GO:0001738)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0070091	glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0	0.1	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0008595	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:1903020	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618) regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.0	GO:0010656	negative regulation of muscle cell apoptotic process(GO:0010656)
0.0	0.0	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.0	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0051446	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0060438	trachea development(GO:0060438)
0.0	0.3	GO:0071805	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:1903670	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.0	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.2	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.1	GO:0048242	epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242)
0.0	0.1	GO:0032964	collagen biosynthetic process(GO:0032964)
0.0	0.0	GO:0060751	branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.0	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0043536	positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.0	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.1	GO:0002347	response to tumor cell(GO:0002347)
0.0	0.1	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.0	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.0	GO:0090026	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0055026	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0007520	syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0	0.0	GO:0072172	ureteric bud formation(GO:0060676) mesonephric tubule formation(GO:0072172)
0.0	0.1	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.2	GO:0008038	neuron recognition(GO:0008038)
0.0	0.1	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.1	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.0	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.3	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.2	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.6	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	0.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	0.4	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.4	GO:0008328	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.5	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.5	GO:0005604	basement membrane(GO:0005604)
0.0	0.7	GO:0030427	site of polarized growth(GO:0030427)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1	0.2	GO:0031782	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1	0.4	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.3	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.3	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.5	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.4	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	1.1	GO:0005518	collagen binding(GO:0005518)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.3	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.3	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.2	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.2	GO:0004970	ionotropic glutamate receptor activity(GO:0004970)
0.0	0.3	GO:0045296	cadherin binding(GO:0045296)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.3	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.3	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.0	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.1	GO:0043394	proteoglycan binding(GO:0043394)
0.0	0.1	GO:0034739	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0005035	death receptor activity(GO:0005035)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.0	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.0	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.0	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.0	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.0	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID ALK1 PATHWAY	ALK1 signaling events
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.7	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
1.0	NABA COLLAGENS	Genes encoding collagen proteins
0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.7	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.7	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening