Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for XBP1

Z-value: 1.58

Motif logo

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Transcription factors associated with XBP1

Gene Symbol Gene ID Gene Info
XBP1
ENSG00000100219.12 XBP1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
XBP1chr22_29191705_2919185643410.154178-0.674.9e-02Click!
XBP1chr22_29195834_291960651720.8550720.609.0e-02Click!
XBP1chr22_29192759_2919291032870.170616-0.491.8e-01Click!
XBP1chr22_29194035_2919432819400.2312880.383.2e-01Click!
XBP1chr22_29194979_291957737450.4889470.383.2e-01Click!

Activity of the XBP1 motif across conditions

Conditions sorted by the z-value of the XBP1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr13_34184837_34185306 0.64 RFC3
 replication factor C (activator 1) 3, 38kDa
 207115
 0.02
chr20_57467710_57467928 0.64 GNAS
 GNAS complex locus
 431
 0.77
chrX_134479032_134479223 0.59 ZNF449
 zinc finger protein 449
 406
 0.77
chr2_220408420_220408618 0.56 CHPF
 chondroitin polymerizing factor
 10
 0.62
chr3_18486507_18486658 0.54 ENSG00000228956
 .
 66
 0.7
chr15_67361022_67361173 0.49 SMAD3
 SMAD family member 3
 2914
 0.37
chr14_76446267_76446546 0.47 TGFB3
 transforming growth factor, beta 3
 930
 0.62
chr21_40406107_40406258 0.46 ENSG00000272015
 .
 139473
 0.04
chrX_39680179_39680466 0.46 ENSG00000263972
 .
 16493
 0.24
chr16_65157518_65157704 0.45 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 1343
 0.63
chr3_9791200_9791462 0.45 OGG1
 8-oxoguanine DNA glycosylase
 297
 0.82
chr16_89830973_89831469 0.44 FANCA
 Fanconi anemia, complementation group A
 19751
 0.11
chr3_134204282_134204486 0.43 CEP63
 centrosomal protein 63kDa
 201
 0.75
chrX_108780083_108780293 0.43 NXT2
 nuclear transport factor 2-like export factor 2
 83
 0.98
chr19_58459192_58459462 0.43 ZNF256
 zinc finger protein 256
 284
 0.84
chr3_196044847_196045072 0.42 TCTEX1D2
 Tctex1 domain containing 2
 200
 0.53
chr4_171030941_171031128 0.41 AADAT
 aminoadipate aminotransferase
 18184
 0.26
chr19_50031295_50031537 0.41 RCN3
 reticulocalbin 3, EF-hand calcium binding domain
 131
 0.88
chr10_45719589_45719755 0.40 ENSG00000207071
 .
 35328
 0.17
chr19_3347090_3347241 0.40 NFIC
 nuclear factor I/C (CCAAT-binding transcription factor)
 12396
 0.18
chr2_238638558_238638814 0.40 LRRFIP1
 leucine rich repeat (in FLII) interacting protein 1
 37704
 0.16
chr20_48553311_48553551 0.40 RNF114
 ring finger protein 114
 483
 0.72
chr2_225792696_225792947 0.39 DOCK10
 dedicator of cytokinesis 10
 18961
 0.28
chr3_107243761_107243927 0.39 BBX
 bobby sox homolog (Drosophila)
 394
 0.92
chr12_4714049_4714390 0.38 DYRK4
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
 68
 0.97
chr14_22996017_22996172 0.38 TRAJ15
 T cell receptor alpha joining 15
 2486
 0.17
chr1_12235343_12235565 0.38 TNFRSF1B
 tumor necrosis factor receptor superfamily, member 1B
 8394
 0.16
chr8_29957431_29957780 0.38 LEPROTL1
 leptin receptor overlapping transcript-like 1
 1851
 0.28
chr1_92350650_92350871 0.38 TGFBR3
 transforming growth factor, beta receptor III
 906
 0.63
chr19_8456957_8457108 0.37 RAB11B-AS1
 RAB11B antisense RNA 1
 1463
 0.2
chr10_76994278_76994482 0.37 COMTD1
 catechol-O-methyltransferase domain containing 1
 1303
 0.47
chr1_203734376_203734572 0.37 LAX1
 lymphocyte transmembrane adaptor 1
 169
 0.94
chr11_60691707_60691884 0.37 TMEM132A
 transmembrane protein 132A
 147
 0.87
chr15_60690387_60690946 0.37 ANXA2
 annexin A2
 275
 0.94
chr3_73672493_73672644 0.37 PDZRN3-AS1
 PDZRN3 antisense RNA 1
 151
 0.94
chr1_109633400_109633594 0.36 RP5-1065J22.8
17
 0.94
chr3_156271681_156272482 0.36 SSR3
 signal sequence receptor, gamma (translocon-associated protein gamma)
 167
 0.96
chr15_86163319_86163521 0.36 RP11-815J21.3
7500
 0.15
chr1_67772983_67773214 0.36 IL12RB2
 interleukin 12 receptor, beta 2
 51
 0.98
chr20_57426529_57426700 0.35 GNAS-AS1
 GNAS antisense RNA 1
 656
 0.52
chr11_61584736_61584906 0.35 FADS1
 fatty acid desaturase 1
 152
 0.86
chr14_23834178_23834353 0.35 EFS
 embryonal Fyn-associated substrate
 154
 0.88
chr19_20011402_20011620 0.35 ZNF93
 zinc finger protein 93
 226
 0.9
chr2_43038576_43038727 0.34 HAAO
 3-hydroxyanthranilate 3,4-dioxygenase
 18919
 0.23
chr7_15722330_15722494 0.34 MEOX2
 mesenchyme homeobox 2
 4025
 0.29
chr10_44341794_44342095 0.34 ENSG00000238957
 .
 188044
 0.03
chr20_37063439_37063660 0.33 ENSG00000200354
 .
 908
 0.36
chr1_43736101_43736371 0.33 TMEM125
 transmembrane protein 125
 381
 0.81
chr3_52566513_52566726 0.33 NT5DC2
 5'-nucleotidase domain containing 2
 928
 0.41
chr1_147860499_147860650 0.33 ENSG00000202064
 .
 229
 0.89
chr1_214280862_214281029 0.33 RP11-53A1.2
76836
 0.11
chr19_54058906_54059057 0.33 ZNF331
 zinc finger protein 331
 240
 0.86
chr11_122050907_122051108 0.33 ENSG00000207994
 .
 27991
 0.16
chr22_40271331_40271542 0.33 ENSG00000238875
 .
 917
 0.58
chr2_182757184_182757414 0.33 SSFA2
 sperm specific antigen 2
 376
 0.76
chrX_47517975_47518127 0.33 UXT-AS1
 UXT antisense RNA 1
 181
 0.76
chr1_204485821_204486049 0.33 MDM4
 Mdm4 p53 binding protein homolog (mouse)
 316
 0.89
chr17_15059171_15059366 0.33 ENSG00000238806
 .
 81932
 0.08
chr15_65186326_65186539 0.33 ENSG00000264929
 .
 6006
 0.16
chr19_20262264_20262447 0.32 CTC-260E6.9
362
 0.76
chr1_196847231_196847470 0.32 CFHR4
 complement factor H-related 4
 9794
 0.22
chr2_119602557_119602736 0.32 EN1
 engrailed homeobox 1
 2608
 0.39
chr9_136202256_136202547 0.32 SURF6
 surfeit 6
 834
 0.32
chr14_45366470_45366675 0.32 C14orf28
 chromosome 14 open reading frame 28
 34
 0.8
chr16_31084353_31084557 0.32 ZNF668
 zinc finger protein 668
 307
 0.69
chr8_38323279_38323475 0.32 FGFR1
 fibroblast growth factor receptor 1
 804
 0.6
chr2_25744901_25745083 0.32 AC104699.1
101006
 0.07
chr5_108745860_108746027 0.32 PJA2
 praja ring finger 2, E3 ubiquitin protein ligase
 248
 0.96
chr6_39901443_39901850 0.32 MOCS1
 molybdenum cofactor synthesis 1
 514
 0.84
chr12_133658056_133658218 0.31 ZNF140
 zinc finger protein 140
 34
 0.96
chr13_102569247_102569398 0.31 FGF14
 fibroblast growth factor 14
 327
 0.92
chr19_42388528_42389094 0.31 ARHGEF1
 Rho guanine nucleotide exchange factor (GEF) 1
 296
 0.84
chr19_16438433_16439148 0.31 KLF2
 Kruppel-like factor 2
 3139
 0.19
chr13_40397646_40397797 0.31 ENSG00000212553
 .
 33643
 0.19
chr9_133454530_133454782 0.31 FUBP3
 far upstream element (FUSE) binding protein 3
 337
 0.91
chr13_23754987_23755138 0.31 SGCG
 sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
 29
 0.98
chr2_62444590_62444741 0.30 B3GNT2
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
 2012
 0.3
chr17_21190411_21190564 0.30 MAP2K3
 mitogen-activated protein kinase kinase 3
 861
 0.6
chr13_47216013_47216251 0.30 LRCH1
 leucine-rich repeats and calponin homology (CH) domain containing 1
 37839
 0.21
chr19_1026324_1026500 0.30 CNN2
 calponin 2
 114
 0.9
chr11_9634927_9635249 0.30 WEE1
 WEE1 G2 checkpoint kinase
 26827
 0.13
chr2_122530051_122530202 0.30 TSN
 translin
 16379
 0.21
chr14_106967068_106967219 0.30 IGHV1-46
 immunoglobulin heavy variable 1-46
 645
 0.33
chrX_53110080_53110473 0.30 TSPYL2
 TSPY-like 2
 1273
 0.44
chr7_65235868_65236176 0.29 ENSG00000206785
 .
 10983
 0.15
chr16_15247007_15247389 0.29 PKD1P6
 polycystic kidney disease 1 (autosomal dominant) pseudogene 6
 1223
 0.28
chr18_59221687_59221979 0.29 CDH20
 cadherin 20, type 2
 4734
 0.36
chr14_50087068_50087296 0.29 RPL36AL
 ribosomal protein L36a-like
 221
 0.56
chr5_119800069_119800772 0.29 PRR16
 proline rich 16
 401
 0.92
chr9_137288070_137288221 0.29 RXRA
 retinoid X receptor, alpha
 10283
 0.23
chr10_30959735_30960082 0.29 SVILP1
 supervillin pseudogene 1
 587
 0.81
chr20_22559380_22559531 0.29 FOXA2
 forkhead box A2
 5646
 0.34
chr1_23749079_23749230 0.29 TCEA3
 transcription elongation factor A (SII), 3
 2046
 0.27
chr17_18061433_18061699 0.29 MYO15A
 myosin XVA
 56
 0.96
chr3_72938425_72938589 0.29 GXYLT2
 glucoside xylosyltransferase 2
 1283
 0.51
chr15_86162061_86162404 0.29 RP11-815J21.3
8688
 0.15
chrX_65857892_65858837 0.29 EDA2R
 ectodysplasin A2 receptor
 519
 0.86
chr18_14852187_14852399 0.29 ENSG00000265499
 .
 22128
 0.19
chr10_28034049_28034242 0.28 MKX
 mohawk homeobox
 378
 0.52
chr3_136153492_136153643 0.28 ENSG00000200571
 .
 4542
 0.28
chr14_33366072_33366949 0.28 NPAS3
 neuronal PAS domain protein 3
 37629
 0.23
chr20_10903511_10903679 0.28 RP11-103J8.1
20663
 0.27
chr6_139308621_139308842 0.28 REPS1
 RALBP1 associated Eps domain containing 1
 46
 0.98
chr14_71373640_71373972 0.28 PCNX
 pecanex homolog (Drosophila)
 316
 0.94
chr12_120218607_120218768 0.28 CIT
 citron (rho-interacting, serine/threonine kinase 21)
 22500
 0.2
chr5_115177794_115178021 0.28 ATG12
 autophagy related 12
 352
 0.71
chrX_57932869_57933095 0.28 ZXDA
 zinc finger, X-linked, duplicated A
 4085
 0.38
chr2_237982035_237982186 0.27 COPS8
 COP9 signalosome subunit 8
 11845
 0.18
chrY_15018181_15018332 0.27 DDX3Y
 DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
 607
 0.83
chr3_196255461_196255682 0.27 SMCO1
 single-pass membrane protein with coiled-coil domains 1
 13334
 0.12
chr9_139972217_139972455 0.27 UAP1L1
 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
 257
 0.74
chr16_17107310_17107606 0.27 CTD-2576D5.4
120903
 0.07
chr15_45880472_45880722 0.27 BLOC1S6
 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
 574
 0.56
chr7_94023741_94023892 0.27 COL1A2
 collagen, type I, alpha 2
 57
 0.99
chr9_91309829_91309980 0.27 ENSG00000265873
 .
 50916
 0.18
chr1_36107852_36108078 0.27 PSMB2
 proteasome (prosome, macropain) subunit, beta type, 2
 520
 0.77
chrX_800237_800388 0.26 SHOX
 short stature homeobox
 208770
 0.02
chr2_102803614_102803903 0.26 IL1RL2
 interleukin 1 receptor-like 2
 16
 0.98
chrY_750238_750389 0.26 NA
 NA
 > 106
 NA
chr4_84030444_84030764 0.26 PLAC8
 placenta-specific 8
 392
 0.89
chr10_112116910_112117211 0.26 SMNDC1
 survival motor neuron domain containing 1
 52351
 0.13
chr1_155145539_155145727 0.26 KRTCAP2
 keratinocyte associated protein 2
 176
 0.54
chr4_39459578_39459788 0.26 RPL9
 ribosomal protein L9
 381
 0.7
chr2_174889838_174890106 0.26 SP3
 Sp3 transcription factor
 59542
 0.15
chr1_239880855_239881135 0.26 ENSG00000233355
 .
 1371
 0.43
chr1_89457123_89457381 0.26 CCBL2
 cysteine conjugate-beta lyase 2
 1035
 0.37
chr2_237881760_237881911 0.26 ENSG00000202341
 .
 42113
 0.17
chr2_99952225_99952767 0.26 TXNDC9
 thioredoxin domain containing 9
 300
 0.84
chr12_54746460_54746646 0.26 RP11-753H16.3
892
 0.29
chr2_228029012_228029295 0.26 COL4A3
 collagen, type IV, alpha 3 (Goodpasture antigen)
 128
 0.75
chr9_115096315_115096686 0.26 PTBP3
 polypyrimidine tract binding protein 3
 553
 0.78
chr5_60458526_60459015 0.25 SMIM15
 small integral membrane protein 15
 469
 0.67
chr17_66592508_66592659 0.25 FAM20A
 family with sequence similarity 20, member A
 4947
 0.26
chr4_157115087_157115238 0.25 ENSG00000221189
 .
 102636
 0.08
chr19_29703517_29704012 0.25 UQCRFS1
 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
 684
 0.77
chr22_18632897_18633158 0.25 USP18
 ubiquitin specific peptidase 18
 361
 0.86
chr16_2184293_2184536 0.25 ENSG00000265867
 .
 1294
 0.14
chr8_11057352_11057503 0.25 XKR6
 XK, Kell blood group complex subunit-related family, member 6
 1421
 0.4
chr1_149831891_149832049 0.25 HIST2H4B
 histone cluster 2, H4b
 734
 0.36
chr10_18468774_18468925 0.25 CACNB2
 calcium channel, voltage-dependent, beta 2 subunit
 38740
 0.2
chr1_98510499_98510650 0.25 ENSG00000225206
 .
 333
 0.94
chr6_19845920_19846071 0.25 RP1-167F1.2
6684
 0.25
chr12_12872464_12872615 0.25 CDKN1B
 cyclin-dependent kinase inhibitor 1B (p27, Kip1)
 1744
 0.27
chr15_92576579_92576730 0.24 RP11-24J19.1
139012
 0.05
chr6_157694117_157694268 0.24 ENSG00000252609
 .
 18239
 0.24
chr9_73026328_73026548 0.24 KLF9
 Kruppel-like factor 9
 3102
 0.35
chr19_54962349_54962752 0.24 LENG8
 leukocyte receptor cluster (LRC) member 8
 83
 0.93
chr17_37123877_37124071 0.24 FBXO47
 F-box protein 47
 319
 0.86
chr16_15006581_15006965 0.24 RP11-958N24.1
1365
 0.22
chr6_170403243_170403627 0.24 RP11-302L19.1
74306
 0.11
chr3_128338529_128338709 0.24 RPN1
 ribophorin I
 31073
 0.16
chr6_27100827_27101032 0.24 HIST1H2AG
 histone cluster 1, H2ag
 97
 0.8
chr2_239195506_239195657 0.24 PER2
 period circadian clock 2
 1626
 0.26
chr17_79010323_79010587 0.24 BAIAP2
 BAI1-associated protein 2
 652
 0.61
chrX_800923_801074 0.24 SHOX
 short stature homeobox
 209456
 0.02
chrY_750926_751077 0.24 NA
 NA
 > 106
 NA
chr5_141443601_141443885 0.24 NDFIP1
 Nedd4 family interacting protein 1
 44327
 0.13
chr14_76044289_76044527 0.24 FLVCR2
 feline leukemia virus subgroup C cellular receptor family, member 2
 552
 0.67
chr7_69946308_69946459 0.24 AUTS2
 autism susceptibility candidate 2
 247742
 0.02
chr1_149804899_149805051 0.24 HIST2H4A
 histone cluster 2, H4a
 748
 0.29
chr9_101983648_101983918 0.24 ALG2
 ALG2, alpha-1,3/1,6-mannosyltransferase
 454
 0.53
chr19_13983519_13983792 0.23 ENSG00000207613
 .
 1858
 0.15
chr4_183004903_183005054 0.23 AC108142.1
1259
 0.55
chr13_102060461_102060612 0.23 NALCN
 sodium leak channel, non-selective
 8170
 0.28
chr14_100259771_100259922 0.23 EML1
 echinoderm microtubule associated protein like 1
 74
 0.98
chr10_14050350_14050950 0.23 FRMD4A
 FERM domain containing 4A
 118
 0.97
chr1_155715028_155715538 0.23 DAP3
 death associated protein 3
 8480
 0.17
chr14_61747147_61747473 0.23 PRKCH
 protein kinase C, eta
 361
 0.67
chr17_79818168_79818378 0.23 P4HB
 prolyl 4-hydroxylase, beta polypeptide
 81
 0.91
chr22_45831450_45831605 0.23 RP1-102D24.5
13097
 0.17
chr21_36935983_36936169 0.23 ENSG00000211590
 .
 156937
 0.04
chr20_4666407_4666914 0.23 PRNP
 prion protein
 222
 0.95
chr20_33680038_33680258 0.23 TRPC4AP
 transient receptor potential cation channel, subfamily C, member 4 associated protein
 462
 0.78
chr14_91225012_91225184 0.23 TTC7B
 tetratricopeptide repeat domain 7B
 27483
 0.2
chr16_16405241_16405629 0.23 ENSG00000265373
 .
 1703
 0.2
chr18_29963098_29963249 0.22 GAREM
 GRB2 associated, regulator of MAPK1
 87222
 0.08
chr7_128378913_128379302 0.22 CALU
 calumenin
 239
 0.88
chr5_175085682_175085863 0.22 HRH2
 histamine receptor H2
 739
 0.7
chr6_13486899_13487420 0.22 GFOD1
 glucose-fructose oxidoreductase domain containing 1
 628
 0.33
chr1_205498395_205498557 0.22 CDK18
 cyclin-dependent kinase 18
 24546
 0.13
chr2_85132966_85133287 0.22 TMSB10
 thymosin beta 10
 377
 0.86
chr13_99506197_99506352 0.22 DOCK9
 dedicator of cytokinesis 9
 1964
 0.38
chr5_140090338_140090717 0.22 ENSG00000199990
 .
 333
 0.72
chr10_133776022_133776178 0.22 BNIP3
 BCL2/adenovirus E1B 19kDa interacting protein 3
 19327
 0.21
chr16_74777769_74777965 0.22 FA2H
 fatty acid 2-hydroxylase
 2700
 0.25
chr15_90643522_90643980 0.22 IDH2
 isocitrate dehydrogenase 2 (NADP+), mitochondrial
 176
 0.93
chrY_1318048_1318199 0.22 NA
 NA
 > 106
 NA
chr20_34250346_34250754 0.22 CPNE1
 copine I
 1930
 0.18
chr1_11753464_11753615 0.22 DRAXIN
 dorsal inhibitory axon guidance protein
 1753
 0.22
chr3_156272520_156272859 0.22 SSR3
 signal sequence receptor, gamma (translocon-associated protein gamma)
 55
 0.98
chr9_136568137_136568308 0.22 SARDH
 sarcosine dehydrogenase
 601
 0.75
chr21_37528132_37528402 0.22 ENSG00000236830
 .
 299
 0.75
chr21_44781922_44782352 0.22 SIK1
 salt-inducible kinase 1
 64871
 0.13
chr15_81589062_81589213 0.22 IL16
 interleukin 16
 117
 0.97
chr7_38351039_38351457 0.22 STARD3NL
 STARD3 N-terminal like
 133251
 0.05
chr5_178770702_178770853 0.22 ADAMTS2
 ADAM metallopeptidase with thrombospondin type 1 motif, 2
 1654
 0.49
chr6_27806026_27806177 0.21 HIST1H2AK
 histone cluster 1, H2ak
 16
 0.77
chrX_100872700_100873033 0.21 ARMCX6
 armadillo repeat containing, X-linked 6
 125
 0.93
chr11_35546514_35546852 0.21 PAMR1
 peptidase domain containing associated with muscle regeneration 1
 468
 0.87
chr18_45968069_45968289 0.21 ZBTB7C
 zinc finger and BTB domain containing 7C
 31056
 0.17

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of XBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045007 depurination(GO:0045007)
0.1 0.2 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.3 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.1 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 0.2 GO:0070669 response to interleukin-2(GO:0070669)
0.1 0.3 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.2 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.1 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.3 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.1 0.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.2 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.3 GO:0051189 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.0 GO:0071371 cellular response to gonadotropin stimulus(GO:0071371)
0.0 0.2 GO:0009109 coenzyme catabolic process(GO:0009109)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.3 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.4 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.2 GO:1903301 regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.2 GO:0090025 regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0070189 kynurenine metabolic process(GO:0070189)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.1 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.1 GO:0051788 response to misfolded protein(GO:0051788)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:0021612 cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612)
0.0 0.2 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.2 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.6 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.1 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.5 GO:0051225 spindle assembly(GO:0051225)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.0 0.1 GO:0051307 resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0 0.0 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.0 GO:0072599 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.0 GO:0061042 vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0035625 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0016137 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 0.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.2 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.1 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0010916 regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0 0.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0042921 corticosteroid receptor signaling pathway(GO:0031958) glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.0 0.2 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.2 GO:0032400 melanosome localization(GO:0032400)
0.0 0.1 GO:0034227 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:0070972 protein localization to endoplasmic reticulum(GO:0070972)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.0 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.1 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.5 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.1 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.0 GO:1903306 negative regulation of regulated secretory pathway(GO:1903306)
0.0 0.2 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.0 GO:0016241 regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.0 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.2 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.0 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.1 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0050935 sensory system development(GO:0048880) lateral line nerve development(GO:0048892) lateral line nerve glial cell differentiation(GO:0048895) lateral line system development(GO:0048925) lateral line nerve glial cell development(GO:0048937) iridophore differentiation(GO:0050935)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:1902591 vesicle coating(GO:0006901) single-organism membrane budding(GO:1902591)
0.0 0.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.0 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0051974 negative regulation of telomerase activity(GO:0051974)
0.0 0.0 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0032366 intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.0 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein(GO:0042517)
0.0 0.0 GO:0006563 L-serine metabolic process(GO:0006563)
0.0 0.0 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.0 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0046039 GTP metabolic process(GO:0046039)
0.0 0.0 GO:0035269 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.0 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.0 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.1 GO:0042772 DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 0.2 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0007220 Notch receptor processing(GO:0007220)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.2 GO:0016460 myosin II complex(GO:0016460)
0.0 0.2 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.3 GO:0042645 mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.0 GO:0033185 mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.4 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 0.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 0.2 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 0.3 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.2 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.4 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.3 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.8 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.4 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.2 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.1 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.3 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0003711 obsolete transcription elongation regulator activity(GO:0003711)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.0 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0 0.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0045502 dynein binding(GO:0045502)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0001846 opsonin binding(GO:0001846)
0.0 0.2 GO:0043531 ADP binding(GO:0043531)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.0 GO:1901567 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.0 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.0 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.6 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade