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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZBTB18

Z-value: 1.91

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Transcription factors associated with ZBTB18

Gene Symbol	Gene ID	Gene Info
ZBTB18 Ensembl NCBI GeneCards UniProt	ENSG00000179456.9	ZBTB18

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZBTB18	chr1_244122588_244122739	91922	0.077504	0.69	4.0e-02	Click!
ZBTB18	chr1_244210323_244211450	3699	0.266547	-0.37	3.3e-01	Click!
ZBTB18	chr1_244217383_244217534	2873	0.289025	-0.35	3.6e-01	Click!
ZBTB18	chr1_244214544_244214695	34	0.980846	0.34	3.7e-01	Click!
ZBTB18	chr1_244215459_244215610	949	0.610254	-0.34	3.7e-01	Click!

Activity of the ZBTB18 motif across conditions

Conditions sorted by the z-value of the ZBTB18 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_54379595_54379934	1.06	RP11-834C11.12		135	0.72
chr2_218866425_218866801	0.97	TNS1	tensin 1	1105	0.51
chrX_19688369_19688923	0.80	SH3KBP1	SH3-domain kinase binding protein 1	166	0.97
chr1_232803371_232803522	0.74	ENSG00000238382	.	32504	0.22
chr21_46891372_46891858	0.71	COL18A1	collagen, type XVIII, alpha 1	16191	0.18
chr4_138452558_138452766	0.69	PCDH18	protocadherin 18	903	0.76
chr12_63194841_63194992	0.65	ENSG00000200296	.	49765	0.16
chr2_163099691_163099877	0.65	FAP	fibroblast activation protein, alpha	182	0.96
chr1_16343782_16344178	0.63	HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	340	0.8
chr12_108983093_108983382	0.62	TMEM119	transmembrane protein 119	8547	0.14
chr4_148402515_148403207	0.59	EDNRA	endothelin receptor type A	777	0.76
chr17_71039690_71039871	0.58	SLC39A11	solute carrier family 39, member 11	46123	0.17
chr3_190812364_190812515	0.58	OSTN	osteocrin	104591	0.07
chr2_20291694_20292044	0.58	RP11-644K8.1		39974	0.13
chr14_61110506_61110736	0.58	SIX1	SIX homeobox 1	5559	0.23
chr7_116167584_116167883	0.57	CAV1	caveolin 1, caveolae protein, 22kDa	1386	0.37
chr8_17308069_17308220	0.57	MTMR7	myotubularin related protein 7	37308	0.17
chr2_175202799_175202950	0.56	AC018470.1	Uncharacterized protein FLJ46347	723	0.62
chr8_40002568_40002719	0.55	C8orf4	chromosome 8 open reading frame 4	8346	0.3
chr3_61580479_61580865	0.54	PTPRG	protein tyrosine phosphatase, receptor type, G	33087	0.24
chr12_102821317_102821468	0.54	IGF1	insulin-like growth factor 1 (somatomedin C)	51037	0.17
chr4_138626508_138626740	0.53	PCDH18	protocadherin 18	172976	0.04
chr5_122615011_122615162	0.53	CEP120	centrosomal protein 120kDa	143911	0.04
chr17_64536538_64536785	0.53	ENSG00000252685	.	97728	0.07
chr7_30357859_30358186	0.53	ENSG00000207771	.	28612	0.17
chr4_135288096_135288247	0.52	PABPC4L	poly(A) binding protein, cytoplasmic 4-like	165268	0.04
chr15_60687226_60687377	0.52	ANXA2	annexin A2	2236	0.4
chr19_41106605_41106828	0.51	LTBP4	latent transforming growth factor beta binding protein 4	561	0.68
chr16_65154176_65154454	0.50	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	1518	0.59
chr4_154506236_154506387	0.49	KIAA0922	KIAA0922	29263	0.2
chr17_70662330_70662481	0.49	ENSG00000200783	.	2114	0.41
chr4_140808041_140808242	0.48	MAML3	mastermind-like 3 (Drosophila)	3065	0.36
chr11_7911988_7912218	0.47	ENSG00000252769	.	1277	0.37
chr6_2385878_2386080	0.47	ENSG00000266252	.	23890	0.26
chr12_13326265_13326502	0.47	EMP1	epithelial membrane protein 1	23267	0.21
chr15_48935948_48936126	0.46	FBN1	fibrillin 1	1881	0.46
chr21_29827177_29827328	0.46	ENSG00000251894	.	288278	0.01
chr5_148521385_148522083	0.46	ABLIM3	actin binding LIM protein family, member 3	124	0.96
chr6_45500446_45500597	0.46	RUNX2	runt-related transcription factor 2	110299	0.06
chr2_151333058_151333209	0.46	RND3	Rho family GTPase 3	8763	0.33
chr13_36366182_36366333	0.46	DCLK1	doublecortin-like kinase 1	63522	0.15
chr1_114522595_114522893	0.46	OLFML3	olfactomedin-like 3	49	0.97
chr2_28211010_28211161	0.45	ENSG00000265321	.	8149	0.25
chr1_198873027_198873178	0.45	ENSG00000207759	.	44820	0.17
chr7_98734981_98735368	0.45	SMURF1	SMAD specific E3 ubiquitin protein ligase 1	6468	0.25
chr11_123065103_123065500	0.45	CLMP	CXADR-like membrane protein	688	0.71
chr4_56731831_56731982	0.44	EXOC1	exocyst complex component 1	12001	0.19
chr5_31955148_31955299	0.44	ENSG00000266243	.	18958	0.21
chr17_77019963_77021139	0.44	C1QTNF1	C1q and tumor necrosis factor related protein 1	208	0.91
chr1_235998951_235999123	0.44	LYST-AS1	LYST antisense RNA 1	3746	0.21
chr7_120969496_120970092	0.44	WNT16	wingless-type MMTV integration site family, member 16	737	0.77
chr11_63767057_63767982	0.44	OTUB1	OTU domain, ubiquitin aldehyde binding 1	13205	0.11
chr5_58655810_58656046	0.43	PDE4D	phosphodiesterase 4D, cAMP-specific	3127	0.41
chr1_177980584_177980776	0.43	SEC16B	SEC16 homolog B (S. cerevisiae)	41332	0.2
chr7_127307743_127307970	0.43	SND1	staphylococcal nuclease and tudor domain containing 1	15622	0.17
chr2_225577018_225577169	0.43	DOCK10	dedicator of cytokinesis 10	74742	0.12
chr10_101548471_101548669	0.42	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	6050	0.22
chr18_499765_500605	0.42	COLEC12	collectin sub-family member 12	537	0.79
chr9_137536456_137536648	0.42	COL5A1	collagen, type V, alpha 1	2932	0.28
chr2_160997260_160997411	0.42	ITGB6	integrin, beta 6	59428	0.14
chr4_119248841_119248992	0.42	PRSS12	protease, serine, 12 (neurotrypsin, motopsin)	25242	0.23
chr5_42683843_42683994	0.42	CCDC152	coiled-coil domain containing 152	72985	0.11
chr18_74797223_74797374	0.41	MBP	myelin basic protein	19919	0.26
chr7_98725447_98725838	0.41	SMURF1	SMAD specific E3 ubiquitin protein ligase 1	16000	0.22
chr7_27187795_27188438	0.41	HOXA6	homeobox A6	723	0.31
chr9_82379166_82379317	0.41	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	57560	0.18
chr22_29106631_29107007	0.41	CHEK2	checkpoint kinase 2	1100	0.47
chr14_37050633_37050993	0.40	NKX2-8	NK2 homeobox 8	999	0.51
chr1_109247037_109247211	0.40	FNDC7	fibronectin type III domain containing 7	8155	0.16
chr13_98905877_98906028	0.40	RP11-573N10.1		20048	0.17
chr1_17306478_17306650	0.40	MFAP2	microfibrillar-associated protein 2	609	0.57
chr10_63402177_63402609	0.39	C10orf107	chromosome 10 open reading frame 107	20326	0.24
chr1_219523892_219524043	0.38	RP11-135J2.4		176664	0.03
chr2_192067901_192068052	0.38	MYO1B	myosin IB	41935	0.16
chr1_87523622_87523774	0.38	HS2ST1	heparan sulfate 2-O-sulfotransferase 1	64933	0.11
chr15_96878792_96878943	0.38	ENSG00000222651	.	2377	0.22
chr8_119499637_119499788	0.38	SAMD12	sterile alpha motif domain containing 12	93409	0.1
chr5_15914551_15914890	0.38	ENSG00000216077	.	20571	0.27
chr17_47654167_47654432	0.38	NXPH3	neurexophilin 3	815	0.39
chr8_95254080_95254242	0.38	GEM	GTP binding protein overexpressed in skeletal muscle	18837	0.21
chr13_48093959_48094110	0.38	ENSG00000244521	.	60665	0.16
chr2_205125099_205125250	0.38	PARD3B	par-3 family cell polarity regulator beta	285342	0.01
chr10_95241473_95241734	0.37	MYOF	myoferlin	348	0.88
chr5_123991118_123991269	0.37	RP11-436H11.2		73331	0.09
chr8_123101527_123101678	0.37	HAS2-AS1	HAS2 antisense RNA 1	447926	0.01
chr10_126416522_126416673	0.37	FAM53B	family with sequence similarity 53, member B	14942	0.16
chr8_49468858_49469448	0.37	RP11-770E5.1		5026	0.35
chr2_46076778_46077115	0.37	PRKCE	protein kinase C, epsilon	151095	0.04
chr11_65084292_65084443	0.37	CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	146	0.93
chr3_123519098_123519249	0.37	MYLK	myosin light chain kinase	6485	0.22
chr11_68038557_68038708	0.37	C11orf24	chromosome 11 open reading frame 24	783	0.67
chr2_237551540_237552008	0.37	ACKR3	atypical chemokine receptor 3	73490	0.12
chr12_70272871_70273022	0.37	MYRFL	myelin regulatory factor-like	47409	0.15
chr12_3004539_3004690	0.37	TULP3	tubby like protein 3	4541	0.13
chr2_98566923_98567218	0.36	ENSG00000238719	.	37490	0.17
chr21_40984409_40984913	0.36	C21orf88	chromosome 21 open reading frame 88	87	0.97
chr10_30248594_30248745	0.36	KIAA1462	KIAA1462	99784	0.08
chr4_81869449_81869600	0.36	BMP3	bone morphogenetic protein 3	82595	0.11
chr1_14033707_14033883	0.36	PRDM2	PR domain containing 2, with ZNF domain	2445	0.3
chr14_69419003_69419387	0.36	ACTN1	actinin, alpha 1	4930	0.26
chr10_33964074_33964254	0.36	NRP1	neuropilin 1	338974	0.01
chr4_141229896_141230299	0.36	ENSG00000252300	.	33831	0.16
chr15_89251638_89251802	0.36	ISG20	interferon stimulated exonuclease gene 20kDa	69536	0.09
chr1_223314396_223314551	0.36	TLR5	toll-like receptor 5	2107	0.46
chr6_101850561_101850712	0.35	GRIK2	glutamate receptor, ionotropic, kainate 2	3482	0.4
chrX_48324188_48324448	0.35	SLC38A5	solute carrier family 38, member 5	1562	0.27
chr15_76000821_76000972	0.35	CSPG4	chondroitin sulfate proteoglycan 4	4293	0.11
chr7_81254313_81254464	0.35	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	137924	0.05
chr15_96703759_96703910	0.35	NR2F2-AS1	NR2F2 antisense RNA 1	62450	0.14
chr3_151903763_151903914	0.35	MBNL1	muscleblind-like splicing regulator 1	81991	0.1
chr6_136256925_136257180	0.35	ENSG00000238921	.	21159	0.21
chr12_57529324_57529537	0.34	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	3508	0.13
chr8_128938263_128938598	0.34	TMEM75	transmembrane protein 75	22161	0.19
chr7_78912183_78912334	0.34	ENSG00000212482	.	60430	0.15
chr7_47367053_47367431	0.34	TNS3	tensin 3	47326	0.2
chr3_53106938_53107738	0.34	ENSG00000266635	.	20324	0.16
chr15_82185842_82186054	0.34	ENSG00000222521	.	150687	0.04
chr4_124981640_124982053	0.34	ANKRD50	ankyrin repeat domain 50	652041	0.0
chr1_36104081_36104260	0.34	PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	3275	0.22
chr7_76145242_76145393	0.33	UPK3B	uroplakin 3B	5385	0.15
chr7_42645149_42645379	0.33	C7orf25	chromosome 7 open reading frame 25	306245	0.01
chr1_38022608_38022888	0.33	DNALI1	dynein, axonemal, light intermediate chain 1	141	0.94
chr16_64927185_64927365	0.33	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	166306	0.04
chr6_16352044_16352195	0.33	ENSG00000265642	.	76635	0.1
chr9_123698083_123698281	0.33	TRAF1	TNF receptor-associated factor 1	6731	0.23
chr2_97189877_97190028	0.33	RP11-363D14.1		8091	0.18
chr16_87802522_87802699	0.32	KLHDC4	kelch domain containing 4	3028	0.24
chr1_228134561_228135379	0.32	WNT9A	wingless-type MMTV integration site family, member 9A	629	0.71
chr17_15160216_15160367	0.32	RP11-849N15.1		4041	0.17
chr7_6298758_6298909	0.32	CYTH3	cytohesin 3	13442	0.18
chr22_40490630_40490805	0.32	TNRC6B	trinucleotide repeat containing 6B	49239	0.13
chr15_49715580_49715731	0.32	FGF7	fibroblast growth factor 7	198	0.96
chr19_39919352_39919568	0.32	PLEKHG2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	4049	0.09
chr1_94793146_94793437	0.32	ARHGAP29	Rho GTPase activating protein 29	90102	0.08
chr9_16828717_16828972	0.32	BNC2	basonuclin 2	3442	0.37
chr19_10337313_10337464	0.32	ENSG00000264266	.	3701	0.1
chr9_131960482_131960899	0.32	RP11-247A12.2		2904	0.19
chr10_49811984_49812175	0.32	ARHGAP22	Rho GTPase activating protein 22	918	0.63
chr6_39760263_39760605	0.31	DAAM2	dishevelled associated activator of morphogenesis 2	292	0.94
chr16_83143220_83143371	0.31	CTD-3253I12.1		119392	0.06
chr7_28076392_28076791	0.31	JAZF1	JAZF zinc finger 1	16173	0.26
chr5_72114694_72114845	0.31	TNPO1	transportin 1	2270	0.27
chr3_29507299_29507450	0.31	ENSG00000216169	.	96462	0.08
chr16_53120024_53120175	0.31	CHD9	chromodomain helicase DNA binding protein 9	12973	0.23
chr4_184338721_184338872	0.31	CDKN2AIP	CDKN2A interacting protein	26948	0.15
chr2_150715873_150716024	0.31	ENSG00000207270	.	248660	0.02
chr10_68685803_68685995	0.31	LRRTM3	leucine rich repeat transmembrane neuronal 3	135	0.98
chr2_190010666_190010817	0.31	ENSG00000264725	.	12904	0.21
chr10_18453497_18453677	0.31	CACNB2	calcium channel, voltage-dependent, beta 2 subunit	23478	0.24
chr8_59661345_59661496	0.31	ENSG00000201231	.	65691	0.12
chr20_49465299_49465721	0.31	ENSG00000265062	.	11935	0.18
chr4_142423380_142423531	0.31	IL15	interleukin 15	134297	0.05
chr1_153517837_153518324	0.31	S100A4	S100 calcium binding protein A4	198	0.86
chr1_34358710_34358861	0.31	RP5-1007G16.1		17718	0.22
chr9_90812890_90813286	0.31	ENSG00000252299	.	176096	0.03
chr6_112652803_112652954	0.31	RFPL4B	ret finger protein-like 4B	15654	0.2
chr8_123814017_123814168	0.30	RP11-44N11.1		5893	0.22
chr2_201483563_201483714	0.30	AOX1	aldehyde oxidase 1	30741	0.18
chr12_86198910_86199116	0.30	RASSF9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	31335	0.22
chr14_33296178_33296329	0.30	AKAP6	A kinase (PRKA) anchor protein 6	91196	0.09
chr6_148608971_148609122	0.30	RP11-631F7.1		4502	0.23
chr3_38216440_38216633	0.30	OXSR1	oxidative stress responsive 1	9540	0.16
chr20_48183167_48183318	0.30	PTGIS	prostaglandin I2 (prostacyclin) synthase	1441	0.45
chr8_107775219_107775370	0.30	ABRA	actin-binding Rho activating protein	7179	0.23
chr8_38068343_38068494	0.30	BAG4	BCL2-associated athanogene 4	3307	0.15
chr19_45751933_45752237	0.30	MARK4	MAP/microtubule affinity-regulating kinase 4	2431	0.2
chr15_48845838_48845989	0.30	FBN1	fibrillin 1	92005	0.08
chr4_126224474_126224625	0.30	FAT4	FAT atypical cadherin 4	13005	0.28
chr12_122897921_122898072	0.29	CLIP1	CAP-GLY domain containing linker protein 1	9120	0.22
chr1_246150409_246150560	0.29	RP11-83A16.1		46369	0.18
chr4_71589225_71589655	0.29	RUFY3	RUN and FYVE domain containing 3	1068	0.4
chr13_35962874_35963128	0.29	MAB21L1	mab-21-like 1 (C. elegans)	87831	0.09
chr4_81116538_81116689	0.29	PRDM8	PR domain containing 8	2045	0.35
chr19_11086584_11086796	0.29	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	8138	0.14
chr11_62211430_62211631	0.29	CTD-2531D15.4		17334	0.11
chr4_157867245_157867396	0.29	PDGFC	platelet derived growth factor C	24735	0.2
chr1_172688052_172688203	0.29	FASLG	Fas ligand (TNF superfamily, member 6)	59969	0.14
chr4_103737426_103737626	0.29	UBE2D3	ubiquitin-conjugating enzyme E2D 3	9173	0.15
chr6_152003026_152003177	0.29	ESR1	estrogen receptor 1	8530	0.26
chr8_71070231_71070382	0.29	NCOA2	nuclear receptor coactivator 2	9611	0.26
chr10_60235150_60235332	0.29	BICC1	bicaudal C homolog 1 (Drosophila)	37659	0.2
chr3_73835117_73835359	0.29	PDZRN3	PDZ domain containing ring finger 3	161147	0.04
chr9_124461801_124462223	0.29	DAB2IP	DAB2 interacting protein	363	0.92
chr3_78233290_78233441	0.29	ENSG00000222574	.	22516	0.26
chr7_26126830_26127131	0.28	ENSG00000266430	.	27021	0.2
chr7_98195950_98196101	0.28	NPTX2	neuronal pentraxin II	50584	0.16
chr3_11138169_11138337	0.28	HRH1	histamine receptor H1	40526	0.18
chr19_1154555_1155129	0.28	SBNO2	strawberry notch homolog 2 (Drosophila)	293	0.85
chr9_79520083_79520617	0.28	PRUNE2	prune homolog 2 (Drosophila)	651	0.82
chr6_82755917_82756068	0.28	ENSG00000223044	.	164165	0.04
chr15_30112674_30113382	0.28	TJP1	tight junction protein 1	723	0.64
chr1_7130330_7130574	0.28	RP11-334N17.1		56113	0.15
chr7_41227215_41227366	0.28	AC005160.3		412133	0.01
chr3_156794251_156794402	0.28	ENSG00000222499	.	59195	0.11
chr3_11680037_11680346	0.28	VGLL4	vestigial like 4 (Drosophila)	5207	0.24
chr3_157157796_157157947	0.28	PTX3	pentraxin 3, long	3293	0.33
chr1_170645055_170645206	0.28	PRRX1	paired related homeobox 1	12052	0.28
chr2_134324863_134325101	0.28	NCKAP5	NCK-associated protein 5	1049	0.62
chr1_246024159_246024310	0.28	RP11-83A16.1		172619	0.03
chr12_50410538_50410689	0.27	RACGAP1	Rac GTPase activating protein 1	110	0.95

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB18

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.5	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.4	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1	0.2	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.4	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.3	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.5	GO:0014824	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.1	0.3	GO:0032506	cytokinetic process(GO:0032506)
0.1	0.2	GO:0061072	iris morphogenesis(GO:0061072)
0.1	0.2	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.3	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.1	0.2	GO:0045112	integrin biosynthetic process(GO:0045112)
0.1	0.2	GO:0051451	myoblast migration(GO:0051451)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.4	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.1	0.1	GO:0031946	regulation of glucocorticoid metabolic process(GO:0031943) regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.1	0.3	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.2	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.3	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.1	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0060502	epithelial cell proliferation involved in lung morphogenesis(GO:0060502)
0.0	0.3	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.3	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.4	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.2	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0061299	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0001878	response to yeast(GO:0001878)
0.0	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.2	GO:0060840	artery morphogenesis(GO:0048844) artery development(GO:0060840)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0052555	positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.0	0.1	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.6	GO:1901185	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	0.1	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.3	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0055012	ventricular cardiac muscle cell differentiation(GO:0055012)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.2	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0000422	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.0	0.1	GO:0042036	negative regulation of cytokine biosynthetic process(GO:0042036)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0040019	positive regulation of embryonic development(GO:0040019)
0.0	0.0	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.1	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.0	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0045987	positive regulation of smooth muscle contraction(GO:0045987)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0071438	invadopodium membrane(GO:0071438)
0.1	0.6	GO:0001527	microfibril(GO:0001527)
0.1	0.3	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.2	GO:0043218	compact myelin(GO:0043218)
0.1	0.6	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.2	GO:0031143	pseudopodium(GO:0031143)
0.0	0.3	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.3	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.1	GO:0000145	exocyst(GO:0000145)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001515	opioid peptide activity(GO:0001515)
0.1	0.3	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.3	GO:0005534	galactose binding(GO:0005534)
0.1	0.2	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1	0.3	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1	0.2	GO:0004948	calcitonin receptor activity(GO:0004948)
0.1	0.6	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.3	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.3	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.2	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.4	GO:0005123	death receptor binding(GO:0005123)
0.0	0.3	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.3	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.4	GO:0005109	frizzled binding(GO:0005109)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.3	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.1	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0030275	LRR domain binding(GO:0030275)
0.0	0.1	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.0	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.0	0.1	GO:0030553	cGMP binding(GO:0030553)
0.0	0.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.0	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.0	GO:0016004	phospholipase activator activity(GO:0016004)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	0.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	0.7	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.7	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.1	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.5	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.1	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.2	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.4	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.7	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	0.2	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.1	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.5	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.5	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint