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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for ZBTB3

Z-value: 1.19

Motif logo

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Transcription factors associated with ZBTB3

Gene Symbol Gene ID Gene Info
ZBTB3
ENSG00000185670.7 zinc finger and BTB domain containing 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_62513178_62513329ZBTB383780.058854-0.561.2e-01Click!
chr11_62520878_62521029ZBTB36780.379523-0.353.5e-01Click!
chr11_62521032_62521282ZBTB34740.531828-0.333.8e-01Click!
chr11_62521434_62521626ZBTB31010.891146-0.039.4e-01Click!
chr11_62521868_62522056ZBTB33020.705283-0.009.9e-01Click!

Activity of the ZBTB3 motif across conditions

Conditions sorted by the z-value of the ZBTB3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr22_37882146_37882335 0.54 MFNG
 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
 185
 0.93
chr13_31309966_31310295 0.45 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 485
 0.88
chrX_70317288_70317439 0.45 FOXO4
 forkhead box O4
 984
 0.38
chrX_153190817_153191535 0.45 ARHGAP4
 Rho GTPase activating protein 4
 522
 0.6
chr3_13057259_13057549 0.44 IQSEC1
 IQ motif and Sec7 domain 1
 28868
 0.23
chr20_54987227_54988129 0.40 CASS4
 Cas scaffolding protein family member 4
 361
 0.82
chr17_73584096_73584435 0.37 MYO15B
 myosin XVB pseudogene
 2593
 0.18
chr12_122584467_122584714 0.37 MLXIP
 MLX interacting protein
 27837
 0.17
chr2_97529082_97529233 0.35 SEMA4C
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
 5168
 0.14
chr1_50575757_50575939 0.35 ELAVL4
 ELAV like neuron-specific RNA binding protein 4
 470
 0.86
chr9_94668432_94668861 0.34 ROR2
 receptor tyrosine kinase-like orphan receptor 2
 42516
 0.2
chrX_128914480_128914899 0.34 SASH3
 SAM and SH3 domain containing 3
 729
 0.68
chr6_24934206_24934437 0.33 FAM65B
 family with sequence similarity 65, member B
 1867
 0.41
chr6_136785760_136785911 0.33 MAP7
 microtubule-associated protein 7
 2178
 0.39
chrX_1653652_1653877 0.32 P2RY8
 purinergic receptor P2Y, G-protein coupled, 8
 2236
 0.34
chr19_4541586_4541737 0.32 LRG1
 leucine-rich alpha-2-glycoprotein 1
 1175
 0.29
chr5_87797997_87798358 0.32 TMEM161B-AS1
 TMEM161B antisense RNA 1
 75665
 0.11
chrY_1603652_1603871 0.32 NA
 NA
 > 106
 NA
chrX_13018542_13018927 0.32 TMSB4X
 thymosin beta 4, X-linked
 24957
 0.19
chr1_21916964_21917115 0.31 ENSG00000221781
 .
 2002
 0.27
chr1_244488212_244488377 0.31 C1orf100
 chromosome 1 open reading frame 100
 27643
 0.22
chr11_93275392_93276314 0.30 SMCO4
 single-pass membrane protein with coiled-coil domains 4
 668
 0.7
chr5_175086058_175086209 0.30 HRH2
 histamine receptor H2
 1100
 0.55
chr17_27467519_27468040 0.30 RP11-321A17.4
278
 0.55
chr14_91696084_91696235 0.30 CTD-2547L24.3
 HCG1816139; Uncharacterized protein
 12944
 0.16
chr19_54804071_54804222 0.30 LILRA3
 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
 27
 0.95
chr1_214484137_214484288 0.29 SMYD2
 SET and MYND domain containing 2
 20108
 0.24
chr1_40860301_40860452 0.29 SMAP2
 small ArfGAP2
 2131
 0.29
chrX_118827540_118827798 0.29 SEPT6
 septin 6
 336
 0.88
chr7_158496672_158497408 0.29 NCAPG2
 non-SMC condensin II complex, subunit G2
 417
 0.87
chr14_95652052_95652434 0.29 CTD-2240H23.2
52
 0.97
chr14_93119065_93119528 0.29 RIN3
 Ras and Rab interactor 3
 450
 0.88
chr17_62153670_62153821 0.29 ERN1
 endoplasmic reticulum to nucleus signaling 1
 53740
 0.09
chr6_139947376_139947865 0.29 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 251863
 0.02
chr7_71523639_71523917 0.29 ENSG00000201014
 .
 144937
 0.05
chr1_40840894_40841045 0.29 SMAP2
 small ArfGAP2
 649
 0.7
chr7_127225793_127226035 0.28 GCC1
 GRIP and coiled-coil domain containing 1
 253
 0.89
chr8_145086499_145086675 0.28 SPATC1
 spermatogenesis and centriole associated 1
 5
 0.83
chr1_235530756_235531012 0.28 TBCE
 tubulin folding cofactor E
 139
 0.96
chr2_121102314_121103173 0.28 INHBB
 inhibin, beta B
 976
 0.66
chr7_37488572_37488804 0.28 ELMO1
 engulfment and cell motility 1
 101
 0.97
chr4_74965175_74965371 0.28 CXCL2
 chemokine (C-X-C motif) ligand 2
 263
 0.9
chr14_21250158_21250382 0.28 RNASE6
 ribonuclease, RNase A family, k6
 1060
 0.33
chr3_187718091_187718280 0.28 LPP
 LIM domain containing preferred translocation partner in lipoma
 152887
 0.04
chr16_29638502_29638653 0.27 ENSG00000266758
 .
 27991
 0.11
chr5_141293636_141294105 0.27 KIAA0141
 KIAA0141
 9503
 0.15
chr3_46185157_46185308 0.27 CCR3
 chemokine (C-C motif) receptor 3
 19864
 0.21
chr6_134547435_134547586 0.27 ENSG00000238631
 .
 19858
 0.17
chr3_129323468_129324020 0.27 PLXND1
 plexin D1
 1917
 0.3
chrX_129306905_129307398 0.27 RAB33A
 RAB33A, member RAS oncogene family
 1528
 0.4
chr3_125486908_125487059 0.27 ENSG00000221737
 .
 22412
 0.17
chr7_38272697_38272848 0.26 STARD3NL
 STARD3 N-terminal like
 54775
 0.17
chr14_105527834_105528220 0.26 GPR132
 G protein-coupled receptor 132
 3740
 0.23
chr13_107572015_107572438 0.26 ENSG00000239050
 .
 55148
 0.17
chr5_77806248_77806529 0.26 LHFPL2
 lipoma HMGIC fusion partner-like 2
 38586
 0.21
chr19_704286_704437 0.26 PALM
 paralemmin
 4592
 0.12
chr3_72226555_72227176 0.26 ENSG00000212070
 .
 84714
 0.11
chr2_46497095_46497294 0.26 EPAS1
 endothelial PAS domain protein 1
 26553
 0.23
chr6_109805084_109805246 0.26 ZBTB24
 zinc finger and BTB domain containing 24
 725
 0.53
chr13_99958033_99958184 0.26 GPR183
 G protein-coupled receptor 183
 1551
 0.41
chr11_121567136_121567530 0.26 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
 106205
 0.08
chrX_48542477_48542733 0.25 WAS
 Wiskott-Aldrich syndrome
 437
 0.75
chr20_48322013_48322164 0.25 B4GALT5
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
 8327
 0.2
chr8_61851632_61851783 0.25 CLVS1
 clavesin 1
 118010
 0.06
chr11_29141848_29142035 0.25 ENSG00000211499
 .
 156295
 0.04
chr5_114878889_114879040 0.25 FEM1C
 fem-1 homolog c (C. elegans)
 1627
 0.42
chr4_159092030_159092251 0.25 RP11-597D13.9
236
 0.78
chr15_33356813_33357043 0.25 FMN1
 formin 1
 3157
 0.36
chr3_43066068_43066219 0.25 FAM198A
 family with sequence similarity 198, member A
 45103
 0.13
chrX_65233867_65234034 0.25 ENSG00000207939
 .
 4762
 0.23
chr5_102202140_102202291 0.25 PAM
 peptidylglycine alpha-amidating monooxygenase
 395
 0.92
chr9_139260720_139260871 0.25 DNLZ
 DNL-type zinc finger
 2554
 0.16
chr4_186631734_186631914 0.24 ENSG00000207497
 .
 703
 0.7
chr3_149194205_149194356 0.24 TM4SF4
 transmembrane 4 L six family member 4
 1794
 0.39
chr20_30640759_30640910 0.24 HCK
 hemopoietic cell kinase
 770
 0.5
chr9_80637867_80638081 0.24 GNAQ
 guanine nucleotide binding protein (G protein), q polypeptide
 7546
 0.32
chr3_50644095_50644246 0.24 CISH
 cytokine inducible SH2-containing protein
 5033
 0.16
chr1_151566174_151566325 0.23 SNX27
 sorting nexin family member 27
 18309
 0.1
chr1_235097453_235097604 0.23 ENSG00000239690
 .
 57595
 0.14
chr11_64009123_64009509 0.23 FKBP2
 FK506 binding protein 2, 13kDa
 96
 0.89
chr15_99500155_99500306 0.23 IGF1R
 insulin-like growth factor 1 receptor
 32401
 0.16
chr2_172877202_172877353 0.23 METAP1D
 methionyl aminopeptidase type 1D (mitochondrial)
 12787
 0.23
chr7_149572287_149572438 0.23 ATP6V0E2
 ATPase, H+ transporting V0 subunit e2
 1230
 0.35
chr15_91446638_91446871 0.23 MAN2A2
 mannosidase, alpha, class 2A, member 2
 220
 0.86
chr2_99388395_99388567 0.23 ENSG00000201070
 .
 10392
 0.22
chr1_39681126_39681366 0.23 RP11-416A14.1
9062
 0.18
chr1_209930383_209930698 0.23 TRAF3IP3
 TRAF3 interacting protein 3
 1016
 0.45
chr6_26157499_26157809 0.23 HIST1H2BD
 histone cluster 1, H2bd
 695
 0.35
chr20_10455686_10455837 0.22 SLX4IP
 SLX4 interacting protein
 39810
 0.16
chr10_22896358_22896509 0.22 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 15791
 0.28
chr1_235114255_235114474 0.22 ENSG00000239690
 .
 74431
 0.11
chr8_52810422_52811259 0.22 PCMTD1
 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
 756
 0.46
chr1_244999063_244999557 0.22 COX20
 COX20 cytochrome C oxidase assembly factor
 392
 0.85
chr1_62208072_62208403 0.22 INADL
 InaD-like (Drosophila)
 88
 0.98
chr7_38352649_38352985 0.22 STARD3NL
 STARD3 N-terminal like
 134820
 0.05
chr16_85887051_85887202 0.22 IRF8
 interferon regulatory factor 8
 45283
 0.1
chr2_219235805_219236126 0.22 ENSG00000225062
 .
 3407
 0.11
chr5_168217801_168217952 0.22 ENSG00000202345
 .
 627
 0.77
chrX_13271711_13271862 0.22 GS1-600G8.3
56985
 0.14
chr14_56381006_56381157 0.22 ENSG00000212522
 .
 154080
 0.04
chrX_70472547_70472698 0.22 ZMYM3
 zinc finger, MYM-type 3
 1357
 0.36
chr3_185870255_185870406 0.22 ETV5
 ets variant 5
 42223
 0.17
chr12_68772939_68773090 0.22 MDM1
 Mdm1 nuclear protein homolog (mouse)
 46853
 0.17
chr16_23159783_23160184 0.22 USP31
 ubiquitin specific peptidase 31
 608
 0.78
chr2_106754814_106755143 0.22 UXS1
 UDP-glucuronate decarboxylase 1
 264
 0.94
chr1_89664351_89664632 0.22 GBP4
 guanylate binding protein 4
 124
 0.96
chr17_79197162_79197682 0.22 AZI1
 5-azacytidine induced 1
 623
 0.55
chr12_96502184_96502412 0.22 ENSG00000266889
 .
 6271
 0.22
chr5_75471567_75471805 0.22 ENSG00000252833
 .
 84060
 0.09
chr1_192777377_192777993 0.21 RGS2
 regulator of G-protein signaling 2, 24kDa
 486
 0.87
chr1_161038546_161039545 0.21 ARHGAP30
 Rho GTPase activating protein 30
 411
 0.65
chr6_163826222_163826373 0.21 QKI
 QKI, KH domain containing, RNA binding
 9378
 0.32
chrX_153978145_153979054 0.21 GAB3
 GRB2-associated binding protein 3
 733
 0.55
chr11_128161363_128161514 0.21 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 213851
 0.02
chr15_75081452_75081829 0.21 ENSG00000264386
 .
 542
 0.49
chr16_85089458_85089881 0.21 KIAA0513
 KIAA0513
 7149
 0.23
chr1_111417492_111418003 0.21 CD53
 CD53 molecule
 1971
 0.34
chr9_139267510_139268079 0.21 CARD9
 caspase recruitment domain family, member 9
 339
 0.79
chr1_100866510_100866661 0.21 ENSG00000216067
 .
 22254
 0.18
chr7_75583164_75583315 0.21 POR
 P450 (cytochrome) oxidoreductase
 155
 0.95
chr12_53719733_53719917 0.21 AAAS
 achalasia, adrenocortical insufficiency, alacrimia
 1283
 0.29
chr17_9937060_9937211 0.21 GAS7
 growth arrest-specific 7
 2719
 0.32
chr9_100668829_100668981 0.21 C9orf156
 chromosome 9 open reading frame 156
 5848
 0.17
chr2_69271007_69271158 0.21 ANTXR1
 anthrax toxin receptor 1
 30553
 0.17
chr7_5862773_5862988 0.21 ZNF815P
 zinc finger protein 815, pseudogene
 42
 0.97
chr16_68122944_68123162 0.21 ENSG00000201850
 .
 393
 0.75
chr11_67042666_67042837 0.21 ADRBK1
 adrenergic, beta, receptor kinase 1
 8799
 0.11
chr12_53023939_53024090 0.21 KRT73
 keratin 73
 11671
 0.11
chr16_2932458_2932721 0.21 FLYWCH2
 FLYWCH family member 2
 598
 0.55
chr10_108596529_108596824 0.20 ENSG00000200626
 .
 133103
 0.06
chr19_55765720_55766271 0.20 PPP6R1
 protein phosphatase 6, regulatory subunit 1
 1142
 0.27
chr17_33863414_33863594 0.20 SLFN12L
 schlafen family member 12-like
 1376
 0.29
chr14_105553392_105553992 0.20 GPR132
 G protein-coupled receptor 132
 21910
 0.17
chr18_25755743_25755974 0.20 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 1552
 0.58
chr5_32709132_32709283 0.20 NPR3
 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
 306
 0.93
chr5_176543501_176543652 0.20 NSD1
 nuclear receptor binding SET domain protein 1
 16504
 0.17
chr22_46682638_46682789 0.20 GTSE1
 G-2 and S-phase expressed 1
 9925
 0.15
chr2_25517043_25517291 0.20 ENSG00000221445
 .
 34423
 0.16
chr8_58779427_58779708 0.20 FAM110B
 family with sequence similarity 110, member B
 127546
 0.06
chr12_54746284_54746435 0.20 RP11-753H16.3
1086
 0.24
chr19_41311125_41311276 0.20 EGLN2
 egl-9 family hypoxia-inducible factor 2
 1847
 0.24
chrX_13108137_13108288 0.20 FAM9C
 family with sequence similarity 9, member C
 45411
 0.18
chr1_96985633_96985784 0.20 ENSG00000241992
 .
 63057
 0.15
chr8_61880060_61880353 0.20 CLVS1
 clavesin 1
 89511
 0.1
chr7_28109764_28109915 0.19 JAZF1
 JAZF zinc finger 1
 1464
 0.51
chr3_37189437_37189588 0.19 ENSG00000199594
 .
 7694
 0.16
chr1_26954743_26954935 0.19 ENSG00000238316
 .
 14041
 0.13
chr3_142683549_142683700 0.19 RP11-372E1.6
285
 0.46
chr13_80809877_80810028 0.19 SPRY2
 sprouty homolog 2 (Drosophila)
 103842
 0.08
chr22_50523028_50523179 0.19 MLC1
 megalencephalic leukoencephalopathy with subcortical cysts 1
 585
 0.67
chr4_8324999_8325150 0.19 HTRA3
 HtrA serine peptidase 3
 53570
 0.12
chr12_11926562_11926926 0.19 ETV6
 ets variant 6
 21309
 0.26
chr5_126187507_126187715 0.19 MARCH3
 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
 66309
 0.11
chr8_95956511_95956662 0.19 TP53INP1
 tumor protein p53 inducible nuclear protein 1
 3385
 0.17
chr12_11807352_11807522 0.19 ETV6
 ets variant 6
 4649
 0.31
chr8_67575803_67576925 0.19 VCPIP1
 valosin containing protein (p97)/p47 complex interacting protein 1
 3088
 0.17
chr1_169763319_169763807 0.19 METTL18
 methyltransferase like 18
 267
 0.75
chr16_66864896_66865106 0.19 NAE1
 NEDD8 activating enzyme E1 subunit 1
 101
 0.95
chr6_159482531_159482682 0.19 TAGAP
 T-cell activation RhoGTPase activating protein
 16422
 0.19
chr5_173202634_173202785 0.19 ENSG00000263401
 .
 45628
 0.18
chr12_29301342_29301647 0.19 FAR2
 fatty acyl CoA reductase 2
 542
 0.83
chr21_38283093_38283244 0.19 HLCS
 holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
 55605
 0.1
chr15_42867116_42867674 0.19 STARD9
 StAR-related lipid transfer (START) domain containing 9
 462
 0.74
chr8_23368073_23368224 0.19 SLC25A37
 solute carrier family 25 (mitochondrial iron transporter), member 37
 18170
 0.16
chr14_70394671_70394822 0.19 SMOC1
 SPARC related modular calcium binding 1
 48603
 0.16
chr17_59487763_59488024 0.19 RP11-332H18.4
1023
 0.34
chr8_2151450_2151601 0.19 MYOM2
 myomesin 2
 158341
 0.04
chr15_58433772_58433923 0.19 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
 2823
 0.28
chr1_222594201_222594352 0.18 ENSG00000222399
 .
 82801
 0.09
chr10_29969861_29970012 0.18 ENSG00000222092
 .
 30908
 0.18
chr6_155054889_155055250 0.18 SCAF8
 SR-related CTD-associated factor 8
 519
 0.85
chr6_136173249_136173683 0.18 PDE7B
 phosphodiesterase 7B
 632
 0.81
chr8_26298579_26298982 0.18 RP11-14I17.3
773
 0.66
chr13_41931400_41931551 0.18 ENSG00000223280
 .
 2680
 0.28
chr11_18548581_18549104 0.18 TSG101
 tumor susceptibility 101
 63
 0.97
chr15_63340381_63340577 0.18 TPM1
 tropomyosin 1 (alpha)
 86
 0.94
chr1_109395002_109395242 0.18 AKNAD1
 AKNA domain containing 1
 217
 0.92
chr10_81007808_81008068 0.18 ZMIZ1
 zinc finger, MIZ-type containing 1
 58037
 0.14
chr17_38476195_38476719 0.18 RARA
 retinoic acid receptor, alpha
 1920
 0.22
chr16_28504630_28504781 0.18 CLN3
 ceroid-lipofuscinosis, neuronal 3
 611
 0.54
chr15_40699677_40699828 0.18 IVD
 isovaleryl-CoA dehydrogenase
 393
 0.72
chr13_24777681_24777832 0.18 ENSG00000252695
 .
 41201
 0.13
chr1_207094900_207095227 0.18 FAIM3
 Fas apoptotic inhibitory molecule 3
 149
 0.94
chr1_28503293_28503444 0.18 PTAFR
 platelet-activating factor receptor
 331
 0.81
chr4_170540985_170541480 0.18 CLCN3
 chloride channel, voltage-sensitive 3
 440
 0.86
chr19_55768482_55768951 0.18 PPP6R1
 protein phosphatase 6, regulatory subunit 1
 1579
 0.19
chr19_56132551_56132702 0.18 ZNF784
 zinc finger protein 784
 3306
 0.09
chr8_101225603_101226122 0.18 ENSG00000199667
 .
 28496
 0.14
chr20_62219212_62219363 0.18 HELZ2
 helicase with zinc finger 2, transcriptional coactivator
 15479
 0.09
chr3_46248309_46248460 0.18 CCR1
 chemokine (C-C motif) receptor 1
 1503
 0.46
chr11_67138355_67138676 0.18 CLCF1
 cardiotrophin-like cytokine factor 1
 2693
 0.12
chr14_59104062_59104397 0.18 DACT1
 dishevelled-binding antagonist of beta-catenin 1
 545
 0.85
chr12_123200741_123200892 0.18 HCAR3
 hydroxycarboxylic acid receptor 3
 623
 0.65
chr2_98630005_98630391 0.18 TMEM131
 transmembrane protein 131
 17810
 0.24
chr1_110025821_110026323 0.18 ATXN7L2
 ataxin 7-like 2
 489
 0.68
chr12_31782840_31782991 0.18 METTL20
 methyltransferase like 20
 17179
 0.15
chr5_138940324_138940673 0.18 UBE2D2
 ubiquitin-conjugating enzyme E2D 2
 253
 0.91
chr6_42989627_42989814 0.18 RRP36
 ribosomal RNA processing 36 homolog (S. cerevisiae)
 337
 0.73
chr17_42846307_42846458 0.18 ADAM11
 ADAM metallopeptidase domain 11
 9689
 0.14
chr1_159823893_159825316 0.18 C1orf204
 chromosome 1 open reading frame 204
 533
 0.6

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1 0.3 GO:0014889 muscle atrophy(GO:0014889)
0.1 0.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.2 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1 0.2 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1 0.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.2 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.1 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.2 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.2 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 0.3 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.1 GO:0044321 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.2 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.3 GO:0032753 positive regulation of interleukin-4 production(GO:0032753)
0.0 0.1 GO:0002830 positive regulation of type 2 immune response(GO:0002830)
0.0 0.2 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0048541 Peyer's patch development(GO:0048541)
0.0 0.0 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.2 GO:0002327 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.0 0.1 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.3 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.1 GO:0060294 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.1 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0 0.2 GO:0001562 response to protozoan(GO:0001562)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0 0.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.1 GO:0002138 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:1902603 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0 0.0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.1 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.0 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.0 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.0 GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0033003 regulation of mast cell activation(GO:0033003)
0.0 0.2 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.2 GO:0007141 male meiosis I(GO:0007141)
0.0 0.0 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0 0.3 GO:0018208 peptidyl-proline modification(GO:0018208)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0043537 negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.1 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.0 GO:0060431 foregut regionalization(GO:0060423) lung field specification(GO:0060424) primary lung bud formation(GO:0060431) lung induction(GO:0060492)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.0 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.0 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0035608 protein deglutamylation(GO:0035608)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.2 GO:0032770 positive regulation of monooxygenase activity(GO:0032770)
0.0 0.0 GO:0010566 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.0 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.3 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:1901538 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.1 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0 0.1 GO:0021513 spinal cord dorsal/ventral patterning(GO:0021513)
0.0 0.0 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.2 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.0 0.1 GO:0090398 cellular senescence(GO:0090398)
0.0 0.0 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.0 GO:0046184 aldehyde biosynthetic process(GO:0046184)
0.0 0.0 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.0 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.0 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.0 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0 0.0 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.0 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.0 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.0 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0000080 mitotic G1 phase(GO:0000080)
0.0 0.0 GO:0033700 phospholipid efflux(GO:0033700)
0.0 0.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.3 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.1 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 0.0 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.0 0.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.0 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.0 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.0 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.3 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.0 GO:0070062 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.4 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.2 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.1 GO:0045159 myosin II binding(GO:0045159)
0.1 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.0 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.3 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.0 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.0 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.0 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.0 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.0 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.0 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.0 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.0 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0004396 hexokinase activity(GO:0004396)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.0 GO:0046980 tapasin binding(GO:0046980)
0.0 0.2 GO:0035586 G-protein coupled nucleotide receptor activity(GO:0001608) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) purinergic receptor activity(GO:0035586) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.0 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0051087 chaperone binding(GO:0051087)
0.0 0.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.0 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.1 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.1 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.2 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.0 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.0 REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine