Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZBTB3

Z-value: 1.19

Motif logo

Transcription factors associated with ZBTB3

Gene Symbol	Gene ID	Gene Info
ZBTB3 Ensembl NCBI GeneCards UniProt	ENSG00000185670.7	ZBTB3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZBTB3	chr11_62513178_62513329	8378	0.058854	-0.56	1.2e-01	Click!
ZBTB3	chr11_62520878_62521029	678	0.379523	-0.35	3.5e-01	Click!
ZBTB3	chr11_62521032_62521282	474	0.531828	-0.33	3.8e-01	Click!
ZBTB3	chr11_62521434_62521626	101	0.891146	-0.03	9.4e-01	Click!
ZBTB3	chr11_62521868_62522056	302	0.705283	-0.00	9.9e-01	Click!

Activity of the ZBTB3 motif across conditions

Conditions sorted by the z-value of the ZBTB3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr22_37882146_37882335	0.54	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	185	0.93
chr13_31309966_31310295	0.45	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	485	0.88
chrX_70317288_70317439	0.45	FOXO4	forkhead box O4	984	0.38
chrX_153190817_153191535	0.45	ARHGAP4	Rho GTPase activating protein 4	522	0.6
chr3_13057259_13057549	0.44	IQSEC1	IQ motif and Sec7 domain 1	28868	0.23
chr20_54987227_54988129	0.40	CASS4	Cas scaffolding protein family member 4	361	0.82
chr17_73584096_73584435	0.37	MYO15B	myosin XVB pseudogene	2593	0.18
chr12_122584467_122584714	0.37	MLXIP	MLX interacting protein	27837	0.17
chr2_97529082_97529233	0.35	SEMA4C	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	5168	0.14
chr1_50575757_50575939	0.35	ELAVL4	ELAV like neuron-specific RNA binding protein 4	470	0.86
chr9_94668432_94668861	0.34	ROR2	receptor tyrosine kinase-like orphan receptor 2	42516	0.2
chrX_128914480_128914899	0.34	SASH3	SAM and SH3 domain containing 3	729	0.68
chr6_24934206_24934437	0.33	FAM65B	family with sequence similarity 65, member B	1867	0.41
chr6_136785760_136785911	0.33	MAP7	microtubule-associated protein 7	2178	0.39
chrX_1653652_1653877	0.32	P2RY8	purinergic receptor P2Y, G-protein coupled, 8	2236	0.34
chr19_4541586_4541737	0.32	LRG1	leucine-rich alpha-2-glycoprotein 1	1175	0.29
chr5_87797997_87798358	0.32	TMEM161B-AS1	TMEM161B antisense RNA 1	75665	0.11
chrY_1603652_1603871	0.32	NA	NA	> 10⁶	NA
chrX_13018542_13018927	0.32	TMSB4X	thymosin beta 4, X-linked	24957	0.19
chr1_21916964_21917115	0.31	ENSG00000221781	.	2002	0.27
chr1_244488212_244488377	0.31	C1orf100	chromosome 1 open reading frame 100	27643	0.22
chr11_93275392_93276314	0.30	SMCO4	single-pass membrane protein with coiled-coil domains 4	668	0.7
chr5_175086058_175086209	0.30	HRH2	histamine receptor H2	1100	0.55
chr17_27467519_27468040	0.30	RP11-321A17.4		278	0.55
chr14_91696084_91696235	0.30	CTD-2547L24.3	HCG1816139; Uncharacterized protein	12944	0.16
chr19_54804071_54804222	0.30	LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	27	0.95
chr1_214484137_214484288	0.29	SMYD2	SET and MYND domain containing 2	20108	0.24
chr1_40860301_40860452	0.29	SMAP2	small ArfGAP2	2131	0.29
chrX_118827540_118827798	0.29	SEPT6	septin 6	336	0.88
chr7_158496672_158497408	0.29	NCAPG2	non-SMC condensin II complex, subunit G2	417	0.87
chr14_95652052_95652434	0.29	CTD-2240H23.2		52	0.97
chr14_93119065_93119528	0.29	RIN3	Ras and Rab interactor 3	450	0.88
chr17_62153670_62153821	0.29	ERN1	endoplasmic reticulum to nucleus signaling 1	53740	0.09
chr6_139947376_139947865	0.29	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	251863	0.02
chr7_71523639_71523917	0.29	ENSG00000201014	.	144937	0.05
chr1_40840894_40841045	0.29	SMAP2	small ArfGAP2	649	0.7
chr7_127225793_127226035	0.28	GCC1	GRIP and coiled-coil domain containing 1	253	0.89
chr8_145086499_145086675	0.28	SPATC1	spermatogenesis and centriole associated 1	5	0.83
chr1_235530756_235531012	0.28	TBCE	tubulin folding cofactor E	139	0.96
chr2_121102314_121103173	0.28	INHBB	inhibin, beta B	976	0.66
chr7_37488572_37488804	0.28	ELMO1	engulfment and cell motility 1	101	0.97
chr4_74965175_74965371	0.28	CXCL2	chemokine (C-X-C motif) ligand 2	263	0.9
chr14_21250158_21250382	0.28	RNASE6	ribonuclease, RNase A family, k6	1060	0.33
chr3_187718091_187718280	0.28	LPP	LIM domain containing preferred translocation partner in lipoma	152887	0.04
chr16_29638502_29638653	0.27	ENSG00000266758	.	27991	0.11
chr5_141293636_141294105	0.27	KIAA0141	KIAA0141	9503	0.15
chr3_46185157_46185308	0.27	CCR3	chemokine (C-C motif) receptor 3	19864	0.21
chr6_134547435_134547586	0.27	ENSG00000238631	.	19858	0.17
chr3_129323468_129324020	0.27	PLXND1	plexin D1	1917	0.3
chrX_129306905_129307398	0.27	RAB33A	RAB33A, member RAS oncogene family	1528	0.4
chr3_125486908_125487059	0.27	ENSG00000221737	.	22412	0.17
chr7_38272697_38272848	0.26	STARD3NL	STARD3 N-terminal like	54775	0.17
chr14_105527834_105528220	0.26	GPR132	G protein-coupled receptor 132	3740	0.23
chr13_107572015_107572438	0.26	ENSG00000239050	.	55148	0.17
chr5_77806248_77806529	0.26	LHFPL2	lipoma HMGIC fusion partner-like 2	38586	0.21
chr19_704286_704437	0.26	PALM	paralemmin	4592	0.12
chr3_72226555_72227176	0.26	ENSG00000212070	.	84714	0.11
chr2_46497095_46497294	0.26	EPAS1	endothelial PAS domain protein 1	26553	0.23
chr6_109805084_109805246	0.26	ZBTB24	zinc finger and BTB domain containing 24	725	0.53
chr13_99958033_99958184	0.26	GPR183	G protein-coupled receptor 183	1551	0.41
chr11_121567136_121567530	0.26	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	106205	0.08
chrX_48542477_48542733	0.25	WAS	Wiskott-Aldrich syndrome	437	0.75
chr20_48322013_48322164	0.25	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	8327	0.2
chr8_61851632_61851783	0.25	CLVS1	clavesin 1	118010	0.06
chr11_29141848_29142035	0.25	ENSG00000211499	.	156295	0.04
chr5_114878889_114879040	0.25	FEM1C	fem-1 homolog c (C. elegans)	1627	0.42
chr4_159092030_159092251	0.25	RP11-597D13.9		236	0.78
chr15_33356813_33357043	0.25	FMN1	formin 1	3157	0.36
chr3_43066068_43066219	0.25	FAM198A	family with sequence similarity 198, member A	45103	0.13
chrX_65233867_65234034	0.25	ENSG00000207939	.	4762	0.23
chr5_102202140_102202291	0.25	PAM	peptidylglycine alpha-amidating monooxygenase	395	0.92
chr9_139260720_139260871	0.25	DNLZ	DNL-type zinc finger	2554	0.16
chr4_186631734_186631914	0.24	ENSG00000207497	.	703	0.7
chr3_149194205_149194356	0.24	TM4SF4	transmembrane 4 L six family member 4	1794	0.39
chr20_30640759_30640910	0.24	HCK	hemopoietic cell kinase	770	0.5
chr9_80637867_80638081	0.24	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	7546	0.32
chr3_50644095_50644246	0.24	CISH	cytokine inducible SH2-containing protein	5033	0.16
chr1_151566174_151566325	0.23	SNX27	sorting nexin family member 27	18309	0.1
chr1_235097453_235097604	0.23	ENSG00000239690	.	57595	0.14
chr11_64009123_64009509	0.23	FKBP2	FK506 binding protein 2, 13kDa	96	0.89
chr15_99500155_99500306	0.23	IGF1R	insulin-like growth factor 1 receptor	32401	0.16
chr2_172877202_172877353	0.23	METAP1D	methionyl aminopeptidase type 1D (mitochondrial)	12787	0.23
chr7_149572287_149572438	0.23	ATP6V0E2	ATPase, H+ transporting V0 subunit e2	1230	0.35
chr15_91446638_91446871	0.23	MAN2A2	mannosidase, alpha, class 2A, member 2	220	0.86
chr2_99388395_99388567	0.23	ENSG00000201070	.	10392	0.22
chr1_39681126_39681366	0.23	RP11-416A14.1		9062	0.18
chr1_209930383_209930698	0.23	TRAF3IP3	TRAF3 interacting protein 3	1016	0.45
chr6_26157499_26157809	0.23	HIST1H2BD	histone cluster 1, H2bd	695	0.35
chr20_10455686_10455837	0.22	SLX4IP	SLX4 interacting protein	39810	0.16
chr10_22896358_22896509	0.22	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	15791	0.28
chr1_235114255_235114474	0.22	ENSG00000239690	.	74431	0.11
chr8_52810422_52811259	0.22	PCMTD1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	756	0.46
chr1_244999063_244999557	0.22	COX20	COX20 cytochrome C oxidase assembly factor	392	0.85
chr1_62208072_62208403	0.22	INADL	InaD-like (Drosophila)	88	0.98
chr7_38352649_38352985	0.22	STARD3NL	STARD3 N-terminal like	134820	0.05
chr16_85887051_85887202	0.22	IRF8	interferon regulatory factor 8	45283	0.1
chr2_219235805_219236126	0.22	ENSG00000225062	.	3407	0.11
chr5_168217801_168217952	0.22	ENSG00000202345	.	627	0.77
chrX_13271711_13271862	0.22	GS1-600G8.3		56985	0.14
chr14_56381006_56381157	0.22	ENSG00000212522	.	154080	0.04
chrX_70472547_70472698	0.22	ZMYM3	zinc finger, MYM-type 3	1357	0.36
chr3_185870255_185870406	0.22	ETV5	ets variant 5	42223	0.17
chr12_68772939_68773090	0.22	MDM1	Mdm1 nuclear protein homolog (mouse)	46853	0.17
chr16_23159783_23160184	0.22	USP31	ubiquitin specific peptidase 31	608	0.78
chr2_106754814_106755143	0.22	UXS1	UDP-glucuronate decarboxylase 1	264	0.94
chr1_89664351_89664632	0.22	GBP4	guanylate binding protein 4	124	0.96
chr17_79197162_79197682	0.22	AZI1	5-azacytidine induced 1	623	0.55
chr12_96502184_96502412	0.22	ENSG00000266889	.	6271	0.22
chr5_75471567_75471805	0.22	ENSG00000252833	.	84060	0.09
chr1_192777377_192777993	0.21	RGS2	regulator of G-protein signaling 2, 24kDa	486	0.87
chr1_161038546_161039545	0.21	ARHGAP30	Rho GTPase activating protein 30	411	0.65
chr6_163826222_163826373	0.21	QKI	QKI, KH domain containing, RNA binding	9378	0.32
chrX_153978145_153979054	0.21	GAB3	GRB2-associated binding protein 3	733	0.55
chr11_128161363_128161514	0.21	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	213851	0.02
chr15_75081452_75081829	0.21	ENSG00000264386	.	542	0.49
chr16_85089458_85089881	0.21	KIAA0513	KIAA0513	7149	0.23
chr1_111417492_111418003	0.21	CD53	CD53 molecule	1971	0.34
chr9_139267510_139268079	0.21	CARD9	caspase recruitment domain family, member 9	339	0.79
chr1_100866510_100866661	0.21	ENSG00000216067	.	22254	0.18
chr7_75583164_75583315	0.21	POR	P450 (cytochrome) oxidoreductase	155	0.95
chr12_53719733_53719917	0.21	AAAS	achalasia, adrenocortical insufficiency, alacrimia	1283	0.29
chr17_9937060_9937211	0.21	GAS7	growth arrest-specific 7	2719	0.32
chr9_100668829_100668981	0.21	C9orf156	chromosome 9 open reading frame 156	5848	0.17
chr2_69271007_69271158	0.21	ANTXR1	anthrax toxin receptor 1	30553	0.17
chr7_5862773_5862988	0.21	ZNF815P	zinc finger protein 815, pseudogene	42	0.97
chr16_68122944_68123162	0.21	ENSG00000201850	.	393	0.75
chr11_67042666_67042837	0.21	ADRBK1	adrenergic, beta, receptor kinase 1	8799	0.11
chr12_53023939_53024090	0.21	KRT73	keratin 73	11671	0.11
chr16_2932458_2932721	0.21	FLYWCH2	FLYWCH family member 2	598	0.55
chr10_108596529_108596824	0.20	ENSG00000200626	.	133103	0.06
chr19_55765720_55766271	0.20	PPP6R1	protein phosphatase 6, regulatory subunit 1	1142	0.27
chr17_33863414_33863594	0.20	SLFN12L	schlafen family member 12-like	1376	0.29
chr14_105553392_105553992	0.20	GPR132	G protein-coupled receptor 132	21910	0.17
chr18_25755743_25755974	0.20	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	1552	0.58
chr5_32709132_32709283	0.20	NPR3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	306	0.93
chr5_176543501_176543652	0.20	NSD1	nuclear receptor binding SET domain protein 1	16504	0.17
chr22_46682638_46682789	0.20	GTSE1	G-2 and S-phase expressed 1	9925	0.15
chr2_25517043_25517291	0.20	ENSG00000221445	.	34423	0.16
chr8_58779427_58779708	0.20	FAM110B	family with sequence similarity 110, member B	127546	0.06
chr12_54746284_54746435	0.20	RP11-753H16.3		1086	0.24
chr19_41311125_41311276	0.20	EGLN2	egl-9 family hypoxia-inducible factor 2	1847	0.24
chrX_13108137_13108288	0.20	FAM9C	family with sequence similarity 9, member C	45411	0.18
chr1_96985633_96985784	0.20	ENSG00000241992	.	63057	0.15
chr8_61880060_61880353	0.20	CLVS1	clavesin 1	89511	0.1
chr7_28109764_28109915	0.19	JAZF1	JAZF zinc finger 1	1464	0.51
chr3_37189437_37189588	0.19	ENSG00000199594	.	7694	0.16
chr1_26954743_26954935	0.19	ENSG00000238316	.	14041	0.13
chr3_142683549_142683700	0.19	RP11-372E1.6		285	0.46
chr13_80809877_80810028	0.19	SPRY2	sprouty homolog 2 (Drosophila)	103842	0.08
chr22_50523028_50523179	0.19	MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	585	0.67
chr4_8324999_8325150	0.19	HTRA3	HtrA serine peptidase 3	53570	0.12
chr12_11926562_11926926	0.19	ETV6	ets variant 6	21309	0.26
chr5_126187507_126187715	0.19	MARCH3	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	66309	0.11
chr8_95956511_95956662	0.19	TP53INP1	tumor protein p53 inducible nuclear protein 1	3385	0.17
chr12_11807352_11807522	0.19	ETV6	ets variant 6	4649	0.31
chr8_67575803_67576925	0.19	VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	3088	0.17
chr1_169763319_169763807	0.19	METTL18	methyltransferase like 18	267	0.75
chr16_66864896_66865106	0.19	NAE1	NEDD8 activating enzyme E1 subunit 1	101	0.95
chr6_159482531_159482682	0.19	TAGAP	T-cell activation RhoGTPase activating protein	16422	0.19
chr5_173202634_173202785	0.19	ENSG00000263401	.	45628	0.18
chr12_29301342_29301647	0.19	FAR2	fatty acyl CoA reductase 2	542	0.83
chr21_38283093_38283244	0.19	HLCS	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	55605	0.1
chr15_42867116_42867674	0.19	STARD9	StAR-related lipid transfer (START) domain containing 9	462	0.74
chr8_23368073_23368224	0.19	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	18170	0.16
chr14_70394671_70394822	0.19	SMOC1	SPARC related modular calcium binding 1	48603	0.16
chr17_59487763_59488024	0.19	RP11-332H18.4		1023	0.34
chr8_2151450_2151601	0.19	MYOM2	myomesin 2	158341	0.04
chr15_58433772_58433923	0.19	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	2823	0.28
chr1_222594201_222594352	0.18	ENSG00000222399	.	82801	0.09
chr10_29969861_29970012	0.18	ENSG00000222092	.	30908	0.18
chr6_155054889_155055250	0.18	SCAF8	SR-related CTD-associated factor 8	519	0.85
chr6_136173249_136173683	0.18	PDE7B	phosphodiesterase 7B	632	0.81
chr8_26298579_26298982	0.18	RP11-14I17.3		773	0.66
chr13_41931400_41931551	0.18	ENSG00000223280	.	2680	0.28
chr11_18548581_18549104	0.18	TSG101	tumor susceptibility 101	63	0.97
chr15_63340381_63340577	0.18	TPM1	tropomyosin 1 (alpha)	86	0.94
chr1_109395002_109395242	0.18	AKNAD1	AKNA domain containing 1	217	0.92
chr10_81007808_81008068	0.18	ZMIZ1	zinc finger, MIZ-type containing 1	58037	0.14
chr17_38476195_38476719	0.18	RARA	retinoic acid receptor, alpha	1920	0.22
chr16_28504630_28504781	0.18	CLN3	ceroid-lipofuscinosis, neuronal 3	611	0.54
chr15_40699677_40699828	0.18	IVD	isovaleryl-CoA dehydrogenase	393	0.72
chr13_24777681_24777832	0.18	ENSG00000252695	.	41201	0.13
chr1_207094900_207095227	0.18	FAIM3	Fas apoptotic inhibitory molecule 3	149	0.94
chr1_28503293_28503444	0.18	PTAFR	platelet-activating factor receptor	331	0.81
chr4_170540985_170541480	0.18	CLCN3	chloride channel, voltage-sensitive 3	440	0.86
chr19_55768482_55768951	0.18	PPP6R1	protein phosphatase 6, regulatory subunit 1	1579	0.19
chr19_56132551_56132702	0.18	ZNF784	zinc finger protein 784	3306	0.09
chr8_101225603_101226122	0.18	ENSG00000199667	.	28496	0.14
chr20_62219212_62219363	0.18	HELZ2	helicase with zinc finger 2, transcriptional coactivator	15479	0.09
chr3_46248309_46248460	0.18	CCR1	chemokine (C-C motif) receptor 1	1503	0.46
chr11_67138355_67138676	0.18	CLCF1	cardiotrophin-like cytokine factor 1	2693	0.12
chr14_59104062_59104397	0.18	DACT1	dishevelled-binding antagonist of beta-catenin 1	545	0.85
chr12_123200741_123200892	0.18	HCAR3	hydroxycarboxylic acid receptor 3	623	0.65
chr2_98630005_98630391	0.18	TMEM131	transmembrane protein 131	17810	0.24
chr1_110025821_110026323	0.18	ATXN7L2	ataxin 7-like 2	489	0.68
chr12_31782840_31782991	0.18	METTL20	methyltransferase like 20	17179	0.15
chr5_138940324_138940673	0.18	UBE2D2	ubiquitin-conjugating enzyme E2D 2	253	0.91
chr6_42989627_42989814	0.18	RRP36	ribosomal RNA processing 36 homolog (S. cerevisiae)	337	0.73
chr17_42846307_42846458	0.18	ADAM11	ADAM metallopeptidase domain 11	9689	0.14
chr1_159823893_159825316	0.18	C1orf204	chromosome 1 open reading frame 204	533	0.6

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.3	GO:0014889	muscle atrophy(GO:0014889)
0.1	0.7	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.1	0.2	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1	0.1	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.2	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1	0.2	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.2	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.2	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.1	0.3	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.1	GO:0044321	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.2	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.3	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.1	GO:0002830	positive regulation of type 2 immune response(GO:0002830)
0.0	0.2	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.2	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.2	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.2	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.2	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0045579	positive regulation of B cell differentiation(GO:0045579)
0.0	0.1	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.3	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.2	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.1	GO:0060294	regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0009129	pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0	0.2	GO:0001562	response to protozoan(GO:0001562)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0	0.2	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.3	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.1	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.3	GO:0006825	copper ion transport(GO:0006825)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:1902603	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.0	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.0	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0033003	regulation of mast cell activation(GO:0033003)
0.0	0.2	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.1	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0002069	columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0	0.3	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.2	GO:0006596	polyamine biosynthetic process(GO:0006596)
0.0	0.1	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.0	GO:0060431	foregut regionalization(GO:0060423) lung field specification(GO:0060424) primary lung bud formation(GO:0060431) lung induction(GO:0060492)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.0	GO:0001878	response to yeast(GO:0001878)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.1	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.2	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.0	GO:0010566	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.3	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:1901538	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.1	GO:0043303	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0	0.1	GO:0021513	spinal cord dorsal/ventral patterning(GO:0021513)
0.0	0.0	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.2	GO:1905037	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0033005	positive regulation of mast cell activation(GO:0033005)
0.0	0.1	GO:0090398	cellular senescence(GO:0090398)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0046184	aldehyde biosynthetic process(GO:0046184)
0.0	0.0	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0	0.0	GO:0032071	regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.0	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.0	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.0	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.0	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.2	GO:0000080	mitotic G1 phase(GO:0000080)
0.0	0.0	GO:0033700	phospholipid efflux(GO:0033700)
0.0	0.1	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.3	GO:0030261	chromosome condensation(GO:0030261)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.0	0.0	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.4	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.3	GO:0032039	integrator complex(GO:0032039)
0.0	0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.8	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.2	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.0	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.2	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.0	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.3	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.3	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.3	GO:0030667	secretory granule membrane(GO:0030667)
0.0	0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1	0.4	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.2	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.1	0.2	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.1	GO:0045159	myosin II binding(GO:0045159)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.2	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.3	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.3	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.3	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.3	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.3	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.3	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.2	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.2	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.4	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.0	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.0	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.0	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.2	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.0	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.0	GO:0046980	tapasin binding(GO:0046980)
0.0	0.2	GO:0035586	G-protein coupled nucleotide receptor activity(GO:0001608) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) purinergic receptor activity(GO:0035586) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.0	GO:0042806	fucose binding(GO:0042806)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.0	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.4	GO:0051087	chaperone binding(GO:0051087)
0.0	0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.5	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	1.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.0	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.1	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.3	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.2	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.2	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.2	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.3	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.4	PID FOXO PATHWAY	FoxO family signaling
0.0	0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.3	PID ARF6 PATHWAY	Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.0	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.5	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.3	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.4	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.0	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.0	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.3	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.4	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.2	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.0	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME CD28 CO STIMULATION	Genes involved in CD28 co-stimulation
0.0	0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.1	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine