Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZBTB49

Z-value: 0.80

Motif logo

Transcription factors associated with ZBTB49

Gene Symbol	Gene ID	Gene Info
ZBTB49 Ensembl NCBI GeneCards UniProt	ENSG00000168826.11	ZBTB49

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZBTB49	chr4_4316995_4317146	12716	0.176457	0.50	1.7e-01	Click!
ZBTB49	chr4_4316659_4316810	12380	0.177030	0.34	3.7e-01	Click!
ZBTB49	chr4_4292047_4292578	316	0.576045	-0.10	7.9e-01	Click!
ZBTB49	chr4_4317457_4317608	13178	0.175678	0.03	9.3e-01	Click!

Activity of the ZBTB49 motif across conditions

Conditions sorted by the z-value of the ZBTB49 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_6481304_6482171	0.83	DENND1C	DENN/MADD domain containing 1C	27	0.95
chr19_2084034_2084229	0.62	MOB3A	MOB kinase activator 3A	1260	0.31
chr21_46340531_46340791	0.60	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	109	0.73
chr12_15111636_15111984	0.56	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	2390	0.25
chr17_3818740_3818909	0.50	P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	970	0.51
chr17_47819247_47819793	0.50	FAM117A	family with sequence similarity 117, member A	17631	0.14
chr7_155150623_155150868	0.46	BLACE	B-cell acute lymphoblastic leukemia expressed	9884	0.18
chr4_40207688_40207871	0.44	RHOH	ras homolog family member H	5815	0.23
chr10_101290718_101290924	0.44	RP11-129J12.2		113	0.96
chr19_42052588_42052799	0.39	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	3193	0.22
chr19_35939406_35939567	0.38	FFAR2	free fatty acid receptor 2	283	0.85
chr6_159465648_159465970	0.38	TAGAP	T-cell activation RhoGTPase activating protein	241	0.93
chr3_53206269_53206420	0.37	PRKCD	protein kinase C, delta	7199	0.18
chr8_8377701_8378015	0.34	ENSG00000263616	.	62307	0.13
chr19_18507519_18507670	0.34	LRRC25	leucine rich repeat containing 25	827	0.4
chr8_27183037_27183778	0.33	PTK2B	protein tyrosine kinase 2 beta	326	0.9
chr2_175459196_175459684	0.33	WIPF1	WAS/WASL interacting protein family, member 1	3053	0.24
chr11_117856643_117857627	0.33	IL10RA	interleukin 10 receptor, alpha	26	0.98
chr17_76254452_76254830	0.32	TMEM235	transmembrane protein 235	26519	0.12
chr16_88714887_88715038	0.31	CYBA	cytochrome b-245, alpha polypeptide	1729	0.19
chr4_15661026_15661177	0.30	FBXL5	F-box and leucine-rich repeat protein 5	386	0.87
chr2_43233189_43233340	0.29	ENSG00000207087	.	85368	0.1
chr17_66286056_66286766	0.29	SLC16A6	solute carrier family 16, member 6	846	0.47
chr19_17862364_17862733	0.28	FCHO1	FCH domain only 1	203	0.91
chr17_70715496_70715723	0.28	ENSG00000222545	.	4999	0.28
chr17_75868336_75868487	0.27	FLJ45079		10248	0.24
chr1_28452162_28452313	0.26	ENSG00000253005	.	17115	0.12
chr3_30653355_30653657	0.26	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	5413	0.33
chrX_12989756_12990021	0.26	TMSB4X	thymosin beta 4, X-linked	3339	0.29
chr15_90728173_90728877	0.26	SEMA4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	330	0.84
chr17_74072761_74073180	0.26	GALR2	galanin receptor 2	2095	0.17
chr22_50752570_50752748	0.26	XX-C283C717.1		401	0.71
chr21_39844669_39844875	0.25	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	25573	0.26
chr17_33379941_33380092	0.25	ENSG00000238858	.	1497	0.28
chr11_14665333_14666638	0.24	PDE3B	phosphodiesterase 3B, cGMP-inhibited	608	0.56
chr17_4487766_4488160	0.23	SMTNL2	smoothelin-like 2	129	0.94
chr3_190306633_190306784	0.23	IL1RAP	interleukin 1 receptor accessory protein	25473	0.22
chr10_73572268_73572419	0.23	CDH23	cadherin-related 23	16815	0.17
chr20_20692062_20692434	0.23	RALGAPA2	Ral GTPase activating protein, alpha subunit 2 (catalytic)	883	0.69
chr3_53156917_53157068	0.22	RFT1	RFT1 homolog (S. cerevisiae)	7435	0.19
chr17_72008833_72008984	0.22	RPL38	ribosomal protein L38	190813	0.02
chr8_134088694_134088845	0.22	SLA	Src-like-adaptor	16166	0.23
chr12_105044004_105044155	0.22	ENSG00000264295	.	58668	0.13
chr3_172429057_172429256	0.22	NCEH1	neutral cholesterol ester hydrolase 1	148	0.95
chr11_128591931_128592082	0.22	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	26088	0.16
chr3_57038204_57038355	0.22	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	26876	0.18
chr17_79005386_79005537	0.22	BAIAP2	BAI1-associated protein 2	3489	0.16
chr6_37140965_37141167	0.22	PIM1	pim-1 oncogene	3087	0.24
chr19_51971494_51971730	0.21	CEACAM18	carcinoembryonic antigen-related cell adhesion molecule 18	8226	0.1
chr19_10405987_10406645	0.21	ICAM5	intercellular adhesion molecule 5, telencephalin	4663	0.08
chr16_88767682_88768006	0.21	RNF166	ring finger protein 166	833	0.34
chr18_74843262_74844680	0.21	MBP	myelin basic protein	331	0.94
chr17_40398832_40398983	0.21	RP11-358B23.5		21698	0.1
chr17_29821977_29822128	0.21	RAB11FIP4	RAB11 family interacting protein 4 (class II)	6926	0.14
chr14_97204377_97204528	0.21	VRK1	vaccinia related kinase 1	59189	0.14
chr12_66585568_66585719	0.20	IRAK3	interleukin-1 receptor-associated kinase 3	2606	0.24
chr17_74261907_74262739	0.20	UBALD2	UBA-like domain containing 2	539	0.68
chr17_55363036_55363187	0.20	MSI2	musashi RNA-binding protein 2	94	0.98
chr9_137820763_137820914	0.20	FCN1	ficolin (collagen/fibrinogen domain containing) 1	11029	0.14
chr1_37943283_37943786	0.20	ZC3H12A	zinc finger CCCH-type containing 12A	3381	0.18
chr16_57721437_57721588	0.19	CCDC135	coiled-coil domain containing 135	7193	0.13
chr3_43221968_43222122	0.19	ENSG00000222331	.	30318	0.18
chr17_74581180_74582274	0.19	ST6GALNAC2	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	483	0.62
chr1_12533236_12533387	0.19	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	5293	0.24
chr9_138844390_138844541	0.18	UBAC1	UBA domain containing 1	8761	0.2
chr13_34116508_34116659	0.18	STARD13	StAR-related lipid transfer (START) domain containing 13	191816	0.03
chr18_74184609_74184760	0.18	ZNF516	zinc finger protein 516	18051	0.17
chrX_123105759_123105910	0.18	STAG2	stromal antigen 2	8814	0.25
chr3_5071207_5071358	0.18	BHLHE40-AS1	BHLHE40 antisense RNA 1	49636	0.12
chr17_75877482_75877763	0.18	FLJ45079		1037	0.6
chr11_74952584_74952761	0.18	TPBGL	trophoblast glycoprotein-like	722	0.6
chr19_44283632_44284486	0.18	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	1350	0.33
chr15_90608186_90608365	0.17	ZNF710	zinc finger protein 710	2971	0.2
chr4_166128900_166129705	0.17	KLHL2	kelch-like family member 2	327	0.55
chr16_53980634_53980785	0.17	FTO	fat mass and obesity associated	12767	0.21
chr1_185284734_185285261	0.17	IVNS1ABP	influenza virus NS1A binding protein	1464	0.44
chr21_46899502_46899653	0.17	COL18A1	collagen, type XVIII, alpha 1	10612	0.2
chr15_31507532_31508310	0.17	TRPM1	transient receptor potential cation channel, subfamily M, member 1	54445	0.15
chr17_46565994_46566145	0.17	ENSG00000206805	.	9610	0.12
chr2_238263784_238263935	0.16	COL6A3	collagen, type VI, alpha 3	32861	0.18
chr16_53552293_53552836	0.16	AKTIP	AKT interacting protein	14241	0.21
chr15_50399834_50400002	0.16	ATP8B4	ATPase, class I, type 8B, member 4	6783	0.25
chr3_52287768_52287956	0.16	PPM1M	protein phosphatase, Mg2+/Mn2+ dependent, 1M	4885	0.1
chr12_54610003_54610573	0.16	ENSG00000265371	.	14972	0.1
chr5_65440502_65441175	0.16	SREK1	splicing regulatory glutamine/lysine-rich protein 1	175	0.55
chr9_97402187_97402338	0.16	FBP1	fructose-1,6-bisphosphatase 1	157	0.97
chr3_14851561_14851984	0.15	FGD5	FYVE, RhoGEF and PH domain containing 5	8697	0.23
chrX_153209082_153209233	0.15	RENBP	renin binding protein	982	0.33
chr22_33223114_33223265	0.15	TIMP3	TIMP metallopeptidase inhibitor 3	25502	0.21
chr21_16886585_16887016	0.15	ENSG00000212564	.	99802	0.08
chr20_60760834_60760985	0.15	MTG2	mitochondrial ribosome-associated GTPase 2	2802	0.2
chr18_24281915_24282066	0.15	ENSG00000265369	.	12497	0.22
chr14_100533458_100533776	0.15	EVL	Enah/Vasp-like	843	0.55
chr14_101013926_101014082	0.15	BEGAIN	brain-enriched guanylate kinase-associated	431	0.78
chr2_135676446_135677712	0.15	CCNT2	cyclin T2	684	0.48
chr3_30683174_30683325	0.15	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	35156	0.21
chr13_28365022_28365726	0.15	GSX1	GS homeobox 1	1406	0.47
chr12_51402747_51402967	0.15	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	175	0.93
chr11_48069657_48069808	0.14	AC103828.1		32325	0.16
chr22_50968790_50969317	0.14	TYMP	thymidine phosphorylase	568	0.45
chr1_36838180_36838356	0.14	STK40	serine/threonine kinase 40	11327	0.12
chr19_19599372_19599523	0.14	GATAD2A	GATA zinc finger domain containing 2A	23157	0.1
chr18_11883181_11883332	0.14	MPPE1	metallophosphoesterase 1	6158	0.13
chrX_95939817_95940209	0.14	DIAPH2	diaphanous-related formin 2	302	0.93
chr1_182758950_182759312	0.14	NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	220	0.94
chr21_36280449_36280667	0.14	RUNX1	runt-related transcription factor 1	18471	0.28
chr19_35609321_35609472	0.14	FXYD3	FXYD domain containing ion transport regulator 3	38	0.95
chr11_65291429_65291724	0.14	SCYL1	SCY1-like 1 (S. cerevisiae)	972	0.38
chr9_90937776_90937927	0.13	ENSG00000252299	.	51333	0.16
chrX_131623914_131624431	0.13	MBNL3	muscleblind-like splicing regulator 3	176	0.97
chr2_74063742_74063893	0.13	STAMBP	STAM binding protein	7659	0.18
chr4_657472_657717	0.13	PDE6B	phosphodiesterase 6B, cGMP-specific, rod, beta	35	0.95
chr14_35591199_35591715	0.13	KIAA0391	KIAA0391	52	0.51
chr14_93672992_93673380	0.13	C14orf142	chromosome 14 open reading frame 142	188	0.52
chr11_94962772_94964135	0.13	RP11-712B9.2		103	0.93
chr4_6695738_6695889	0.13	S100P	S100 calcium binding protein P	1017	0.4
chr7_142012838_142012989	0.13	PRSS3P3	protease, serine, 3 pseudogene 3	23304	0.2
chr7_26952596_26952747	0.13	SKAP2	src kinase associated phosphoprotein 2	48309	0.14
chr21_45285452_45286244	0.13	AGPAT3	1-acylglycerol-3-phosphate O-acyltransferase 3	781	0.65
chr6_14734934_14735085	0.13	ENSG00000206960	.	88243	0.1
chr15_31650164_31650315	0.13	KLF13	Kruppel-like factor 13	8118	0.31
chr16_58018530_58018844	0.13	TEPP	testis, prostate and placenta expressed	8348	0.13
chr17_27716871_27717334	0.12	TAOK1	TAO kinase 1	380	0.47
chr5_175560458_175560649	0.12	FAM153B	family with sequence similarity 153, member B	48644	0.12
chr6_33545433_33545584	0.12	BAK1	BCL2-antagonist/killer 1	2473	0.2
chr4_88770427_88770578	0.12	MEPE	matrix extracellular phosphoglycoprotein	16363	0.19
chr10_101689512_101689663	0.12	DNMBP	dynamin binding protein	1166	0.47
chr9_130666481_130666789	0.12	ST6GALNAC6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	974	0.33
chr8_95652342_95652927	0.12	ESRP1	epithelial splicing regulatory protein 1	668	0.52
chr19_2164749_2165707	0.12	DOT1L	DOT1-like histone H3K79 methyltransferase	1044	0.38
chr7_142902930_142903081	0.12	TAS2R40	taste receptor, type 2, member 40	16125	0.11
chr2_2690202_2690353	0.12	ENSG00000263570	.	330825	0.01
chr16_56703515_56703666	0.12	MT1H	metallothionein 1H	136	0.88
chr4_53525685_53526428	0.12	USP46	ubiquitin specific peptidase 46	554	0.78
chr7_997543_997694	0.12	ADAP1	ArfGAP with dual PH domains 1	2575	0.2
chr16_81480914_81481100	0.12	CMIP	c-Maf inducing protein	2232	0.39
chr7_142510250_142510438	0.11	PRSS3P2	protease, serine, 3 pseudogene 2	29213	0.14
chr11_66311190_66311580	0.11	ZDHHC24	zinc finger, DHHC-type containing 24	2321	0.15
chr5_156692539_156692693	0.11	CYFIP2	cytoplasmic FMR1 interacting protein 2	475	0.65
chr12_50156324_50156475	0.11	TMBIM6	transmembrane BAX inhibitor motif containing 6	9652	0.16
chr2_162100897_162101225	0.11	AC009299.2		6612	0.21
chr6_42018642_42019010	0.11	TAF8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	164	0.87
chr19_34669041_34669419	0.11	LSM14A	LSM14A, SCD6 homolog A (S. cerevisiae)	5667	0.28
chr2_219085570_219085950	0.11	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	3827	0.15
chr2_219233529_219233805	0.11	ENSG00000225062	.	1109	0.3
chr17_65417991_65418142	0.11	ENSG00000201547	.	13069	0.14
chr19_10704746_10704897	0.11	AP1M2	adaptor-related protein complex 1, mu 2 subunit	6830	0.1
chr13_48893876_48894215	0.11	RB1	retinoblastoma 1	16134	0.25
chr11_45101502_45101653	0.11	PRDM11	PR domain containing 11	13987	0.27
chr19_3275241_3275448	0.11	AC010649.1		27575	0.14
chr7_86946956_86947107	0.11	CROT	carnitine O-octanoyltransferase	27966	0.2
chr9_96708088_96708484	0.11	BARX1	BARX homeobox 1	7427	0.27
chr9_67671299_67671450	0.11	ENSG00000199432	.	93148	0.07
chr15_67316943_67317094	0.11	SMAD3	SMAD family member 3	39083	0.2
chr8_101964485_101964756	0.11	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	160	0.95
chr1_38019125_38019899	0.11	SNIP1	Smad nuclear interacting protein 1	391	0.79
chr22_45625958_45626109	0.11	KIAA0930	KIAA0930	3249	0.23
chr1_95582420_95583278	0.11	TMEM56	transmembrane protein 56	45	0.91
chr21_34440256_34440407	0.11	OLIG1	oligodendrocyte transcription factor 1	2119	0.27
chr13_20795977_20796128	0.11	GJB6	gap junction protein, beta 6, 30kDa	9065	0.2
chr7_156797777_156797998	0.11	MNX1-AS2	MNX1 antisense RNA 2	1114	0.45
chr9_139925276_139925479	0.11	FUT7	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)	2085	0.1
chr5_153422227_153422378	0.10	MFAP3	microfibrillar-associated protein 3	3743	0.24
chr3_45718385_45718593	0.10	LIMD1-AS1	LIMD1 antisense RNA 1	11885	0.18
chrX_103357104_103358067	0.10	ZCCHC18	zinc finger, CCHC domain containing 18	383	0.86
chr3_56949082_56949233	0.10	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	1342	0.51
chr13_25115593_25116500	0.10	ENSG00000266216	.	13405	0.17
chr16_84631467_84631681	0.10	RP11-61F12.1		3575	0.21
chr17_25659717_25660000	0.10	WSB1	WD repeat and SOCS box containing 1	38486	0.16
chr1_182808109_182808399	0.10	DHX9	DEAH (Asp-Glu-Ala-His) box helicase 9	250	0.93
chr4_16083981_16084260	0.10	PROM1	prominin 1	111	0.98
chr3_36985452_36986747	0.10	TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	449	0.83
chr17_36859477_36859845	0.10	ENSG00000265930	.	1077	0.24
chr9_123922153_123922304	0.10	CNTRL	centriolin	2107	0.3
chr2_118943251_118943914	0.10	INSIG2	insulin induced gene 2	97532	0.08
chr2_62530766_62530917	0.10	ENSG00000238809	.	38711	0.15
chr9_136207992_136208143	0.10	ENSG00000201451	.	3406	0.08
chr22_43253501_43253661	0.10	ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	173	0.96
chr19_14229110_14229381	0.10	PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	349	0.62
chr17_29814991_29815971	0.10	RAB11FIP4	RAB11 family interacting protein 4 (class II)	355	0.83
chr14_78108377_78108627	0.10	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	25386	0.16
chr12_104572024_104572175	0.10	TXNRD1	thioredoxin reductase 1	37458	0.13
chr7_65216059_65216706	0.10	CCT6P1	chaperonin containing TCP1, subunit 6 (zeta) pseudogene 1	253	0.9
chr17_36860259_36860862	0.10	MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	1235	0.2
chr17_19093169_19093320	0.10	ENSG00000264940	.	314	0.77
chr17_29399050_29399201	0.10	RP11-271K11.5		21081	0.11
chr22_46988879_46989444	0.10	GRAMD4	GRAM domain containing 4	16135	0.21
chr12_51716816_51717143	0.09	BIN2	bridging integrator 2	920	0.52
chr9_102584292_102585830	0.09	NR4A3	nuclear receptor subfamily 4, group A, member 3	924	0.68
chr4_57775517_57776061	0.09	REST	RE1-silencing transcription factor	1714	0.37
chr16_4357890_4358162	0.09	GLIS2	GLIS family zinc finger 2	6736	0.14
chr1_203676024_203676175	0.09	ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	16926	0.18
chr14_91125349_91125500	0.09	TTC7B	tetratricopeptide repeat domain 7B	14872	0.16
chr16_643128_643307	0.09	RAB40C	RAB40C, member RAS oncogene family	2885	0.1
chr8_103251470_103251823	0.09	KB-431C1.4		24	0.81
chr1_55616949_55617132	0.09	USP24	ubiquitin specific peptidase 24	63722	0.11
chr9_127531935_127532859	0.09	RP11-175D17.3		5	0.95
chr20_32700274_32700759	0.09	EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	378	0.87
chr3_160473528_160474334	0.09	PPM1L	protein phosphatase, Mg2+/Mn2+ dependent, 1L	65	0.95
chr17_1515004_1515155	0.09	ENSG00000238946	.	4510	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB49

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.2	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.2	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.1	GO:0046037	GMP metabolic process(GO:0046037)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.4	GO:1990266	neutrophil chemotaxis(GO:0030593) neutrophil migration(GO:1990266)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.0	GO:0044321	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.3	GO:0005844	polysome(GO:0005844)
0.0	0.5	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	GO:0016151	nickel cation binding(GO:0016151)
0.3	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.2	GO:0005522	profilin binding(GO:0005522)
0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.1	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.2	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	GO:0043560	insulin receptor substrate binding(GO:0043560)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.2	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling