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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZIC1

Z-value: 1.28

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Transcription factors associated with ZIC1

Gene Symbol	Gene ID	Gene Info
ZIC1 Ensembl NCBI GeneCards UniProt	ENSG00000152977.5	ZIC1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZIC1	chr3_147131973_147132124	4877	0.208815	0.84	4.2e-03	Click!
ZIC1	chr3_147126089_147126240	1007	0.450791	0.83	5.3e-03	Click!
ZIC1	chr3_147142704_147142855	15608	0.186611	0.82	6.9e-03	Click!
ZIC1	chr3_147115262_147115580	3739	0.210134	0.81	8.5e-03	Click!
ZIC1	chr3_147111194_147111421	375	0.850874	0.80	9.0e-03	Click!

Activity of the ZIC1 motif across conditions

Conditions sorted by the z-value of the ZIC1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_108520152_108520684	0.81	FAM155A	family with sequence similarity 155, member A	1335	0.55
chr17_75317825_75318000	0.80	SEPT9	septin 9	780	0.69
chr10_110225810_110226152	0.79	ENSG00000222436	.	475087	0.01
chr2_158113918_158114875	0.72	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	286	0.93
chr12_81102183_81102935	0.67	MYF6	myogenic factor 6 (herculin)	1282	0.49
chr8_126013201_126013598	0.66	SQLE	squalene epoxidase	2613	0.23
chr6_123110376_123110857	0.64	SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A	145	0.96
chr9_12776208_12776436	0.63	LURAP1L	leucine rich adaptor protein 1-like	1302	0.47
chr2_142887906_142888379	0.62	LRP1B	low density lipoprotein receptor-related protein 1B	432	0.87
chr2_27301899_27302732	0.61	EMILIN1	elastin microfibril interfacer 1	880	0.32
chr9_8857014_8857547	0.59	PTPRD	protein tyrosine phosphatase, receptor type, D	496	0.84
chr17_29887299_29887674	0.58	ENSG00000207614	.	471	0.69
chr4_113739356_113739869	0.57	ANK2	ankyrin 2, neuronal	347	0.9
chr6_48037118_48037375	0.57	PTCHD4	patched domain containing 4	821	0.78
chr2_235862821_235863118	0.55	SH3BP4	SH3-domain binding protein 4	2249	0.48
chr6_12292037_12292313	0.55	EDN1	endothelin 1	1579	0.54
chrX_8699533_8700279	0.54	KAL1	Kallmann syndrome 1 sequence	321	0.94
chr15_101513524_101514094	0.54	LRRK1	leucine-rich repeat kinase 1	54259	0.12
chr12_110993281_110993585	0.53	PPTC7	PTC7 protein phosphatase homolog (S. cerevisiae)	27692	0.12
chr20_34471632_34471916	0.52	ENSG00000201221	.	3807	0.18
chrX_117250265_117250710	0.51	KLHL13	kelch-like family member 13	274	0.95
chrX_151142056_151142353	0.50	GABRE	gamma-aminobutyric acid (GABA) A receptor, epsilon	939	0.49
chr22_46454527_46455045	0.50	RP6-109B7.3		3991	0.12
chr3_9989057_9989268	0.50	PRRT3-AS1	PRRT3 antisense RNA 1	74	0.93
chr5_73729921_73730212	0.49	ENSG00000244326	.	116255	0.06
chr5_166406240_166406516	0.48	TENM2	teneurin transmembrane protein 2	305426	0.01
chr3_87040086_87040946	0.48	VGLL3	vestigial like 3 (Drosophila)	247	0.96
chr8_127837007_127837644	0.48	ENSG00000212451	.	153558	0.04
chr7_127899527_127899678	0.48	LEP	leptin	18265	0.16
chr4_106816123_106816518	0.48	NPNT	nephronectin	274	0.81
chr19_51161641_51162497	0.47	C19orf81	chromosome 19 open reading frame 81	9024	0.12
chr9_130341109_130341430	0.47	FAM129B	family with sequence similarity 129, member B	1	0.98
chr2_149894818_149895436	0.47	LYPD6B	LY6/PLAUR domain containing 6B	105	0.98
chr14_71022448_71023169	0.47	ADAM20	ADAM metallopeptidase domain 20	21076	0.17
chr4_175750179_175750687	0.46	GLRA3	glycine receptor, alpha 3	32	0.99
chr20_9049976_9050220	0.46	PLCB4	phospholipase C, beta 4	350	0.89
chr10_34815325_34815760	0.45	PARD3	par-3 family cell polarity regulator	99883	0.09
chr6_166075279_166075470	0.45	PDE10A	phosphodiesterase 10A	183	0.97
chr1_16472641_16472879	0.45	RP11-276H7.2		8946	0.12
chr3_8809480_8810320	0.44	OXTR	oxytocin receptor	463	0.76
chr13_30157377_30157646	0.44	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	3418	0.36
chr9_23821130_23821679	0.44	ELAVL2	ELAV like neuron-specific RNA binding protein 2	74	0.99
chr17_28667391_28667637	0.44	ENSG00000207132	.	4108	0.15
chr10_6443642_6443853	0.44	DKFZP667F0711		51469	0.16
chr19_14605464_14605615	0.44	GIPC1	GIPC PDZ domain containing family, member 1	1405	0.26
chr2_10526122_10526400	0.44	HPCAL1	hippocalcin-like 1	33886	0.15
chr14_89769991_89770787	0.44	RP11-356K23.1		46240	0.14
chr7_116660327_116660575	0.43	ST7	suppression of tumorigenicity 7	120	0.96
chr12_56075239_56075869	0.42	METTL7B	methyltransferase like 7B	224	0.86
chr5_92908415_92908864	0.42	ENSG00000237187	.	1590	0.42
chr1_1283171_1284080	0.42	DVL1	dishevelled segment polarity protein 1	867	0.32
chr8_41165761_41166040	0.42	SFRP1	secreted frizzled-related protein 1	1116	0.48
chr4_138974934_138975159	0.42	ENSG00000250033	.	3572	0.39
chr6_10383738_10384217	0.42	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	20850	0.18
chr12_54676753_54676980	0.42	HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	884	0.34
chr1_33367226_33367525	0.41	TMEM54	transmembrane protein 54	385	0.8
chr9_102591075_102591263	0.41	NR4A3	nuclear receptor subfamily 4, group A, member 3	2160	0.4
chr11_77733968_77734525	0.41	KCTD14	potassium channel tetramerization domain containing 14	94	0.72
chr6_4369736_4370097	0.41	ENSG00000201185	.	58281	0.15
chr3_123476244_123476543	0.40	MYLK	myosin light chain kinase	36295	0.15
chr1_170633420_170634117	0.40	PRRX1	paired related homeobox 1	690	0.8
chr2_153193063_153193456	0.40	FMNL2	formin-like 2	1508	0.52
chr20_47299051_47299422	0.40	ENSG00000251876	.	56749	0.16
chr6_76234416_76234599	0.40	FILIP1	filamin A interacting protein 1	31053	0.15
chr7_93550787_93551002	0.40	GNG11	guanine nucleotide binding protein (G protein), gamma 11	117	0.96
chr1_109490979_109491171	0.40	CLCC1	chloride channel CLIC-like 1	1985	0.29
chr1_153581254_153581448	0.40	S100A16	S100 calcium binding protein A16	462	0.62
chr9_132096752_132097176	0.40	ENSG00000242281	.	35776	0.16
chr11_122028989_122029168	0.40	ENSG00000207994	.	6062	0.18
chr8_94859053_94859497	0.40	TMEM67	transmembrane protein 67	61778	0.09
chr11_61685093_61685479	0.39	RAB3IL1	RAB3A interacting protein (rabin3)-like 1	289	0.85
chr2_176931780_176932252	0.39	EVX2	even-skipped homeobox 2	16625	0.1
chr1_201430589_201431038	0.39	PHLDA3	pleckstrin homology-like domain, family A, member 3	7499	0.16
chr5_33891538_33892159	0.39	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	198	0.94
chr2_216296824_216297216	0.38	FN1	fibronectin 1	3770	0.26
chr11_122046887_122047202	0.38	ENSG00000207994	.	24028	0.16
chr18_53087556_53087938	0.38	TCF4	transcription factor 4	1839	0.39
chr1_13910795_13911459	0.38	PDPN	podoplanin	362	0.87
chr11_131416298_131416516	0.38	AP003025.2		5646	0.24
chr2_85632386_85633119	0.38	CAPG	capping protein (actin filament), gelsolin-like	3186	0.11
chr11_2949356_2950534	0.38	PHLDA2	pleckstrin homology-like domain, family A, member 2	740	0.54
chr4_38121545_38121863	0.38	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	74212	0.12
chr1_60031328_60031726	0.38	FGGY	FGGY carbohydrate kinase domain containing	11937	0.3
chr19_52222495_52223170	0.38	HAS1	hyaluronan synthase 1	110	0.94
chr10_25155972_25156509	0.38	ENSG00000240294	.	41501	0.18
chr2_1711742_1712354	0.38	PXDN	peroxidasin homolog (Drosophila)	15706	0.26
chr11_8832007_8832297	0.37	ST5	suppression of tumorigenicity 5	44	0.97
chr9_94710782_94711296	0.37	ROR2	receptor tyrosine kinase-like orphan receptor 2	123	0.98
chr2_63893254_63893651	0.37	ENSG00000221085	.	29217	0.21
chr7_83278228_83278460	0.37	SEMA3E	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	18	0.99
chr1_65774988_65775539	0.37	DNAJC6	DnaJ (Hsp40) homolog, subfamily C, member 6	35	0.98
chr2_196978205_196978455	0.37	RP11-347P5.1		37657	0.15
chr7_117512754_117513170	0.37	CTTNBP2	cortactin binding protein 2	599	0.85
chr3_134088468_134088746	0.36	AMOTL2	angiomotin like 2	2147	0.35
chr20_8112947_8113200	0.36	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)	199	0.97
chr20_10651235_10651457	0.36	RP11-103J8.1		2230	0.35
chr11_65259449_65259600	0.36	SCYL1	SCY1-like 1 (S. cerevisiae)	33024	0.08
chr14_100204021_100204271	0.36	EML1	echinoderm microtubule associated protein like 1	60	0.98
chr7_90084746_90084920	0.36	CDK14	cyclin-dependent kinase 14	10905	0.23
chr3_45241366_45241603	0.36	TMEM158	transmembrane protein 158 (gene/pseudogene)	26286	0.18
chr19_13136060_13136211	0.36	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	324	0.8
chr8_495850_496251	0.36	TDRP	testis development related protein	269	0.95
chrX_153595297_153595831	0.36	FLNA	filamin A, alpha	4087	0.1
chr7_89841494_89841721	0.35	STEAP2	STEAP family member 2, metalloreductase	362	0.65
chr14_85707273_85707789	0.35	ENSG00000252529	.	30745	0.26
chr1_112933403_112933636	0.35	CTTNBP2NL	CTTNBP2 N-terminal like	5284	0.23
chr1_44300309_44300553	0.35	ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	64829	0.09
chr6_38230060_38230313	0.35	ENSG00000200706	.	55136	0.16
chr12_77625749_77626115	0.35	ENSG00000238769	.	69127	0.14
chr2_181559754_181559963	0.34	ENSG00000264976	.	77925	0.12
chr9_35341457_35341792	0.34	AL160274.1	HCG17281; PRO0038; Uncharacterized protein	19638	0.2
chr3_64670816_64671530	0.34	ADAMTS9-AS2	ADAMTS9 antisense RNA 2	369	0.87
chr6_27205685_27206711	0.34	PRSS16	protease, serine, 16 (thymus)	9282	0.19
chr4_74735225_74735723	0.34	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	353	0.85
chr5_176899210_176899576	0.34	DBN1	drebrin 1	478	0.65
chr2_79739509_79740065	0.34	CTNNA2	catenin (cadherin-associated protein), alpha 2	339	0.91
chr19_48016527_48016998	0.34	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	703	0.59
chr10_52834229_52834739	0.33	PRKG1	protein kinase, cGMP-dependent, type I	550	0.81
chr17_74536772_74536989	0.33	PRCD	progressive rod-cone degeneration	708	0.43
chr5_2752991_2753357	0.33	C5orf38	chromosome 5 open reading frame 38	795	0.6
chr22_30601263_30601429	0.33	RP3-438O4.4		1752	0.27
chr6_130450991_130451225	0.33	RP11-73O6.3		8233	0.25
chr3_23713475_23713674	0.33	ENSG00000212269	.	30491	0.19
chr1_33207592_33208218	0.32	KIAA1522	KIAA1522	419	0.8
chr7_36195246_36195841	0.32	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	2666	0.32
chr1_167789688_167789943	0.32	RP1-313L4.3		171	0.96
chr20_46412966_46413363	0.32	SULF2	sulfatase 2	1069	0.59
chr12_113683537_113683756	0.32	TPCN1	two pore segment channel 1	1473	0.33
chr18_421335_421729	0.32	RP11-720L2.2		2884	0.33
chr2_218714763_218715120	0.32	TNS1	tensin 1	8058	0.27
chr18_8948520_8948699	0.32	RP11-674N23.4		146955	0.04
chr7_84815825_84816071	0.31	SEMA3D	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	223	0.97
chr14_96671190_96671644	0.31	RP11-404P21.8	Uncharacterized protein	236	0.48
chr3_42113480_42113939	0.31	TRAK1	trafficking protein, kinesin binding 1	18853	0.25
chr11_57267285_57267491	0.31	SLC43A1	solute carrier family 43 (amino acid system L transporter), member 1	1404	0.25
chr22_31198410_31198813	0.31	OSBP2	oxysterol binding protein 2	462	0.84
chr20_55800377_55800528	0.31	RP4-813D12.2		10524	0.2
chr2_37870062_37870489	0.31	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	4526	0.29
chr16_75284494_75285397	0.31	BCAR1	breast cancer anti-estrogen resistance 1	100	0.96
chr16_65154751_65155029	0.30	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	943	0.75
chr19_9473504_9474272	0.30	ZNF177	zinc finger protein 177	181	0.93
chr5_1494740_1494891	0.30	LPCAT1	lysophosphatidylcholine acyltransferase 1	29277	0.18
chr10_77155014_77155181	0.30	ENSG00000237149	.	6180	0.2
chr5_136481655_136482067	0.30	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	167366	0.04
chr9_130860823_130861938	0.30	SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	544	0.57
chr7_101268427_101268664	0.30	MYL10	myosin, light chain 10, regulatory	4031	0.33
chr17_71287404_71287786	0.30	CDC42EP4	CDC42 effector protein (Rho GTPase binding) 4	19952	0.15
chr12_5541333_5541550	0.30	NTF3	neurotrophin 3	162	0.98
chr1_216773992_216774229	0.30	ESRRG	estrogen-related receptor gamma	122564	0.06
chr8_66861458_66861787	0.29	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	72173	0.12
chr6_47666429_47666580	0.29	GPR115	G protein-coupled receptor 115	215	0.94
chrX_17395960_17396111	0.29	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	2492	0.32
chr4_184797459_184798247	0.29	STOX2	storkhead box 2	28656	0.22
chr6_143605233_143605462	0.29	AL031320.1		154228	0.03
chr2_205410516_205411018	0.29	PARD3B	par-3 family cell polarity regulator beta	44	0.99
chr2_133015015_133015166	0.28	ENSG00000221288	.	437	0.85
chr10_112159035_112159217	0.28	ENSG00000221359	.	34873	0.17
chr2_41837870_41838465	0.28	ENSG00000221372	.	14641	0.29
chr11_74022029_74022645	0.28	P4HA3	prolyl 4-hydroxylase, alpha polypeptide III	348	0.87
chr11_5618695_5618968	0.28	TRIM6	tripartite motif containing 6	795	0.34
chr3_38150153_38150438	0.28	ENSG00000201965	.	16590	0.14
chr12_53443889_53444561	0.28	TENC1	tensin like C1 domain containing phosphatase (tensin 2)	255	0.86
chr1_30556615_30556878	0.28	ENSG00000222787	.	198997	0.03
chr1_59229210_59229361	0.28	ENSG00000264081	.	1322	0.47
chr19_16272076_16272227	0.28	CIB3	calcium and integrin binding family member 3	12135	0.11
chr5_2752285_2752739	0.28	C5orf38	chromosome 5 open reading frame 38	133	0.91
chr2_242499136_242499442	0.27	BOK-AS1	BOK antisense RNA 1	897	0.38
chr4_100326128_100326285	0.27	ADH7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	25242	0.19
chr5_36608256_36608472	0.27	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	67	0.99
chr7_117468363_117468588	0.27	CTTNBP2	cortactin binding protein 2	36641	0.22
chr4_23890798_23891066	0.27	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	726	0.8
chr13_77457508_77457742	0.27	KCTD12	potassium channel tetramerization domain containing 12	2900	0.26
chr1_6795750_6796041	0.27	ENSG00000239166	.	16884	0.16
chr17_41327724_41327928	0.27	NBR1	neighbor of BRCA1 gene 1	4566	0.16
chr3_141378576_141378773	0.27	RNF7	ring finger protein 7	78372	0.09
chr14_77606808_77607442	0.27	ZDHHC22	zinc finger, DHHC-type containing 22	38	0.57
chr18_47090550_47090839	0.27	LIPG	lipase, endothelial	1979	0.29
chr8_141129048_141129349	0.27	C8orf17	chromosome 8 open reading frame 17	185782	0.03
chr15_44450903_44451054	0.27	FRMD5	FERM domain containing 5	35666	0.19
chr9_93834219_93834510	0.27	SYK	spleen tyrosine kinase	244594	0.02
chr1_17560057_17560274	0.27	PADI1	peptidyl arginine deiminase, type I	315	0.88
chr3_185815817_185816010	0.27	ETV5	ets variant 5	10420	0.22
chr8_118993051_118993436	0.27	EXT1	exostosin glycosyltransferase 1	129410	0.06
chr1_144708044_144708206	0.27	RP11-640M9.2		92994	0.07
chr9_36163620_36163822	0.27	CCIN	calicin	5668	0.19
chr11_131618597_131618988	0.27	NTM	neurotrimin	87904	0.1
chr17_42636239_42636390	0.27	FZD2	frizzled family receptor 2	1389	0.42
chr8_35234925_35235076	0.27	UNC5D	unc-5 homolog D (C. elegans)	141707	0.05
chr10_128947024_128947230	0.27	FAM196A	family with sequence similarity 196, member A	28146	0.24
chr12_93293392_93293882	0.27	EEA1	early endosome antigen 1	29470	0.2
chr10_24738095_24738342	0.27	KIAA1217	KIAA1217	144	0.97
chr17_70636816_70636967	0.27	ENSG00000200783	.	23400	0.24
chr12_105626746_105626963	0.27	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	374	0.89
chr22_43547615_43548743	0.27	TSPO	translocator protein (18kDa)	242	0.9
chr11_73099035_73099239	0.27	RP11-809N8.2		8344	0.15
chr2_219596210_219596511	0.27	TTLL4	tubulin tyrosine ligase-like family, member 4	5937	0.15
chr4_24796744_24797030	0.26	SOD3	superoxide dismutase 3, extracellular	198	0.97
chr19_55917680_55917831	0.26	UBE2S	ubiquitin-conjugating enzyme E2S	1332	0.21
chr11_7013739_7013936	0.26	ZNF214	zinc finger protein 214	27629	0.13
chr1_152488256_152488562	0.26	CRCT1	cysteine-rich C-terminal 1	1431	0.33

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.1	0.4	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.4	GO:0031223	auditory behavior(GO:0031223)
0.1	0.5	GO:0014820	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.1	0.4	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.6	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.1	0.4	GO:0007343	egg activation(GO:0007343)
0.1	0.2	GO:0003079	obsolete positive regulation of natriuresis(GO:0003079)
0.1	0.3	GO:0071294	cellular response to zinc ion(GO:0071294)
0.1	0.3	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.1	0.3	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1	0.3	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.1	0.3	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.1	0.3	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.3	GO:0060872	semicircular canal development(GO:0060872)
0.1	0.4	GO:0061430	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.1	0.1	GO:0060435	bronchiole development(GO:0060435)
0.1	0.3	GO:0018101	protein citrullination(GO:0018101)
0.1	0.1	GO:0071699	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.5	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.3	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.1	0.5	GO:0036303	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.1	0.2	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.4	GO:0042693	muscle cell fate commitment(GO:0042693)
0.1	0.2	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.2	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.1	0.1	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.1	0.2	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.3	GO:0018126	protein hydroxylation(GO:0018126)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.4	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.2	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.2	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.2	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.6	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.1	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.2	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.3	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.3	GO:0071305	cellular response to vitamin D(GO:0071305)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.2	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.3	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.2	GO:0090026	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.1	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.1	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.8	GO:0006024	glycosaminoglycan biosynthetic process(GO:0006024)
0.0	0.2	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0045964	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0003207	cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0	0.1	GO:0001878	response to yeast(GO:0001878)
0.0	0.2	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.1	GO:0072502	cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.2	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0042482	positive regulation of odontogenesis(GO:0042482)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.2	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.0	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.2	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0072133	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.0	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.0	0.3	GO:0046697	decidualization(GO:0046697)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:1903306	negative regulation of regulated secretory pathway(GO:1903306)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.2	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.3	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.2	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.2	GO:0045176	apical protein localization(GO:0045176)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0060039	pericardium development(GO:0060039)
0.0	0.1	GO:0032373	positive regulation of sterol transport(GO:0032373) positive regulation of cholesterol transport(GO:0032376)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.2	GO:0043949	regulation of cAMP-mediated signaling(GO:0043949)
0.0	0.1	GO:0030238	male sex determination(GO:0030238)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:0046398	UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0090030	regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.4	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.1	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.2	GO:0001569	patterning of blood vessels(GO:0001569)
0.0	0.1	GO:0007619	courtship behavior(GO:0007619)
0.0	0.7	GO:0016358	dendrite development(GO:0016358)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0045916	negative regulation of protein processing(GO:0010955) negative regulation of complement activation(GO:0045916) negative regulation of protein maturation(GO:1903318) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0010826	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.2	GO:0006893	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.0	GO:0060008	Sertoli cell differentiation(GO:0060008) Sertoli cell development(GO:0060009)
0.0	0.9	GO:0034332	adherens junction organization(GO:0034332)
0.0	0.0	GO:0003179	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.3	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.3	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.0	0.1	GO:0061515	erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.0	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.0	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.0	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.0	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.0	0.0	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0050922	negative regulation of chemotaxis(GO:0050922)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.0	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.4	GO:0070374	positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0	0.0	GO:0051531	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0043438	acetoacetic acid metabolic process(GO:0043438)
0.0	0.1	GO:0048169	regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0	0.2	GO:0007405	neuroblast proliferation(GO:0007405)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.0	GO:0048016	inositol phosphate-mediated signaling(GO:0048016)
0.0	0.1	GO:0032462	regulation of protein homooligomerization(GO:0032462)
0.0	0.1	GO:0002070	epithelial cell maturation(GO:0002070)
0.0	0.1	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.0	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.0	GO:0042754	negative regulation of circadian sleep/wake cycle, sleep(GO:0042321) negative regulation of circadian rhythm(GO:0042754) negative regulation of behavior(GO:0048521)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0099518	vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.0	0.1	GO:0099504	synaptic vesicle cycle(GO:0099504)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.4	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.0	GO:0046851	negative regulation of bone remodeling(GO:0046851)
0.0	0.0	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.1	GO:0071445	obsolete cellular response to protein stimulus(GO:0071445)
0.0	0.1	GO:0019430	removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0	0.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.2	GO:0035338	long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0	0.1	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0046902	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.1	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.0	GO:0001774	microglial cell activation(GO:0001774)
0.0	0.0	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.0	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
0.0	0.0	GO:0043584	nose development(GO:0043584)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1	0.2	GO:0001940	male pronucleus(GO:0001940)
0.1	0.6	GO:0043205	fibril(GO:0043205)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.5	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.4	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.3	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.3	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.3	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	0.0	GO:0044291	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.3	GO:0042641	actomyosin(GO:0042641)
0.0	0.2	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.6	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.2	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.1	GO:0032982	myosin filament(GO:0032982)
0.0	0.0	GO:0032059	bleb(GO:0032059)
0.0	0.0	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	4.2	GO:0031012	extracellular matrix(GO:0031012)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.2	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.6	GO:0030426	growth cone(GO:0030426)
0.0	1.1	GO:0030016	myofibril(GO:0030016)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.0	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.4	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	0.6	GO:0005000	vasopressin receptor activity(GO:0005000)
0.1	0.5	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1	0.3	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.1	0.6	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.1	0.3	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	0.2	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.4	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1	0.3	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.3	GO:0008517	folic acid transporter activity(GO:0008517)
0.1	0.2	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.3	GO:0048406	nerve growth factor binding(GO:0048406)
0.1	0.7	GO:0030553	cGMP binding(GO:0030553)
0.1	0.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	0.4	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	0.7	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.1	0.4	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.1	0.2	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1	0.3	GO:0005497	androgen binding(GO:0005497)
0.1	0.3	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.8	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.2	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.2	GO:0005534	galactose binding(GO:0005534)
0.0	1.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.3	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.9	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.3	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.3	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.2	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0019798	procollagen-proline dioxygenase activity(GO:0019798)
0.0	0.1	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0	0.4	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.5	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.6	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.2	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
0.0	0.3	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0044620	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.4	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	1.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.9	GO:0008009	chemokine activity(GO:0008009)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.3	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.3	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0004936	alpha-adrenergic receptor activity(GO:0004936)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.0	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.3	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.0	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.3	GO:0019905	syntaxin binding(GO:0019905)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0005109	frizzled binding(GO:0005109)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.2	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.2	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.7	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.9	ST G ALPHA I PATHWAY	G alpha i Pathway
0.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.4	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.9	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.3	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.4	PID EPHB FWD PATHWAY	EPHB forward signaling
0.4	PID AURORA B PATHWAY	Aurora B signaling
0.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
1.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	ST ADRENERGIC	Adrenergic Pathway
0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
1.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
1.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.5	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.5	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.3	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.6	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.2	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.7	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	REACTOME HEMOSTASIS	Genes involved in Hemostasis
0.0	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.6	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC