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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZIC3_ZIC4

Z-value: 0.79

Motif logo

Transcription factors associated with ZIC3_ZIC4

Gene Symbol	Gene ID	Gene Info
ZIC3 Ensembl NCBI GeneCards UniProt	ENSG00000156925.7	ZIC3
ZIC4 Ensembl NCBI GeneCards UniProt	ENSG00000174963.13	ZIC4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZIC3	chrX_136650028_136650459	1566	0.394980	0.53	1.4e-01	Click!
ZIC3	chrX_136649219_136649370	617	0.726656	-0.41	2.8e-01	Click!
ZIC3	chrX_136651041_136651192	2439	0.293855	-0.29	4.4e-01	Click!
ZIC3	chrX_136647691_136647934	489	0.730082	0.28	4.7e-01	Click!
ZIC3	chrX_136650504_136650655	1902	0.343807	0.14	7.1e-01	Click!
ZIC4	chr3_147125315_147125495	758	0.586247	0.43	2.5e-01	Click!
ZIC4	chr3_147125608_147125766	1040	0.434514	0.34	3.7e-01	Click!
ZIC4	chr3_147125110_147125261	538	0.729018	0.20	6.1e-01	Click!

Activity of the ZIC3_ZIC4 motif across conditions

Conditions sorted by the z-value of the ZIC3_ZIC4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_110872434_110873339	0.44	MALL	mal, T-cell differentiation protein-like	713	0.63
chr2_236401822_236402641	0.37	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	502	0.83
chr20_60941163_60941716	0.36	LAMA5	laminin, alpha 5	887	0.46
chr1_201616947_201617125	0.34	NAV1	neuron navigator 1	341	0.86
chr6_33387553_33387744	0.34	SYNGAP1	synaptic Ras GTPase activating protein 1	199	0.87
chr4_184094744_184094905	0.32	ENSG00000252048	.	3260	0.22
chr13_24477780_24477964	0.31	C1QTNF9B	C1q and tumor necrosis factor related protein 9B	1078	0.48
chr19_3688376_3688653	0.31	PIP5K1C	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	11874	0.1
chr17_38599985_38600404	0.31	IGFBP4	insulin-like growth factor binding protein 4	481	0.74
chr10_128250315_128250594	0.30	ENSG00000221717	.	4821	0.29
chr14_24837426_24838101	0.26	NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	216	0.85
chr9_112262221_112262626	0.25	PTPN3	protein tyrosine phosphatase, non-receptor type 3	1833	0.4
chr20_30457693_30458808	0.24	DUSP15	dual specificity phosphatase 15	125	0.67
chr15_89248242_89248620	0.24	ISG20	interferon stimulated exonuclease gene 20kDa	66247	0.09
chr8_143533593_143534231	0.23	BAI1	brain-specific angiogenesis inhibitor 1	3121	0.27
chr20_25565265_25566139	0.23	NINL	ninein-like	451	0.81
chr4_7972052_7972961	0.23	AFAP1	actin filament associated protein 1	30853	0.14
chr8_102092961_102093560	0.23	ENSG00000202360	.	56927	0.13
chr22_44222171_44222754	0.23	RP3-388M5.9		14089	0.16
chr2_23608861_23609561	0.22	KLHL29	kelch-like family member 29	1123	0.67
chrX_73639854_73640301	0.22	SLC16A2	solute carrier family 16, member 2 (thyroid hormone transporter)	1008	0.55
chr1_156646561_156647039	0.22	NES	nestin	389	0.72
chr17_48625105_48625289	0.21	SPATA20	spermatogenesis associated 20	677	0.5
chr7_391737_391888	0.21	AC187652.1	Protein LOC100996433	88894	0.08
chr17_38721330_38721617	0.21	CCR7	chemokine (C-C motif) receptor 7	238	0.92
chr13_113777141_113777292	0.21	F10	coagulation factor X	84	0.95
chr8_22140544_22140695	0.21	PIWIL2	piwi-like RNA-mediated gene silencing 2	7539	0.14
chr19_3606102_3607092	0.20	TBXA2R	thromboxane A2 receptor	61	0.89
chr1_1410134_1410538	0.20	ATAD3B	ATPase family, AAA domain containing 3B	3187	0.12
chr6_151562009_151562901	0.20	AKAP12	A kinase (PRKA) anchor protein 12	946	0.51
chr7_155598385_155598815	0.20	SHH	sonic hedgehog	3166	0.3
chr19_10024160_10024434	0.20	OLFM2	olfactomedin 2	215	0.91
chr10_110671781_110671954	0.20	ENSG00000222436	.	29201	0.27
chr16_66878332_66879083	0.20	CA7	carbonic anhydrase VII	128	0.94
chrX_30326616_30326849	0.20	NR0B1	nuclear receptor subfamily 0, group B, member 1	127	0.96
chr16_4364778_4365572	0.20	GLIS2	GLIS family zinc finger 2	413	0.78
chr5_126625896_126626411	0.19	MEGF10	multiple EGF-like-domains 10	370	0.91
chr11_66233628_66233779	0.19	PELI3	pellino E3 ubiquitin protein ligase family member 3	513	0.59
chr8_41510934_41511242	0.19	NKX6-3	NK6 homeobox 3	2233	0.21
chr19_42497759_42498630	0.19	ATP1A3	ATPase, Na+/K+ transporting, alpha 3 polypeptide	37	0.97
chr19_49561050_49561269	0.19	CGB7	chorionic gonadotropin, beta polypeptide 7	151	0.85
chr3_183948174_183948496	0.19	VWA5B2	von Willebrand factor A domain containing 5B2	118	0.93
chr9_1051774_1052480	0.19	DMRT2	doublesex and mab-3 related transcription factor 2	513	0.84
chr7_117512754_117513170	0.18	CTTNBP2	cortactin binding protein 2	599	0.85
chr1_33207034_33207258	0.18	KIAA1522	KIAA1522	340	0.85
chr12_124871047_124871198	0.18	NCOR2	nuclear receptor corepressor 2	2248	0.42
chr1_176748344_176748495	0.18	ENSG00000202609	.	250162	0.02
chr17_59481988_59482187	0.18	RP11-332H18.5		4483	0.14
chr17_20491916_20492779	0.18	CDRT15L2	CMT1A duplicated region transcript 15-like 2	9310	0.21
chr19_8675123_8675468	0.18	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	290	0.88
chr19_14585851_14586099	0.18	PTGER1	prostaglandin E receptor 1 (subtype EP1), 42kDa	199	0.89
chr7_150671802_150672427	0.18	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	2900	0.18
chr13_24007256_24007423	0.17	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	502	0.88
chrX_53349448_53350467	0.17	IQSEC2	IQ motif and Sec7 domain 2	565	0.73
chr15_22893749_22894042	0.17	CYFIP1	cytoplasmic FMR1 interacting protein 1	1179	0.51
chr4_2283428_2283729	0.17	ZFYVE28	zinc finger, FYVE domain containing 28	5864	0.13
chr10_90911880_90912031	0.17	CH25H	cholesterol 25-hydroxylase	55116	0.1
chr3_71149968_71150208	0.17	FOXP1	forkhead box P1	29656	0.25
chr10_28287400_28288216	0.17	ARMC4	armadillo repeat containing 4	169	0.97
chr2_23607446_23607927	0.17	KLHL29	kelch-like family member 29	402	0.92
chr7_94287847_94287998	0.17	PEG10	paternally expressed 10	2240	0.29
chr4_2418580_2419575	0.17	ZFYVE28	zinc finger, FYVE domain containing 28	1259	0.44
chr7_151106792_151107040	0.17	WDR86	WD repeat domain 86	190	0.8
chr2_149633771_149633995	0.17	KIF5C	kinesin family member 5C	1064	0.51
chr17_60215726_60216261	0.17	ENSG00000207123	.	16312	0.22
chr19_3062101_3062252	0.17	AES	amino-terminal enhancer of split	379	0.78
chr8_23583978_23584470	0.16	RP11-175E9.1		19570	0.15
chr4_80603993_80604144	0.16	OR7E94P	olfactory receptor, family 7, subfamily E, member 94 pseudogene	94784	0.09
chr1_244893304_244893776	0.16	DESI2	desumoylating isopeptidase 2	76487	0.09
chr3_44100057_44100240	0.16	ENSG00000252980	.	12431	0.26
chr7_29846053_29846716	0.16	WIPF3	WAS/WASL interacting protein family, member 3	282	0.94
chr4_111532746_111532897	0.16	PITX2	paired-like homeodomain 2	11386	0.28
chr6_88875424_88876640	0.16	CNR1	cannabinoid receptor 1 (brain)	46	0.99
chr7_106685641_106686008	0.16	PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	730	0.74
chrX_153686737_153687403	0.16	PLXNA3	plexin A3	449	0.6
chr2_208635896_208636047	0.16	FZD5	frizzled family receptor 5	1684	0.3
chr2_131792690_131793026	0.16	ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	5992	0.24
chr4_150999769_151000790	0.16	DCLK2	doublecortin-like kinase 2	99	0.98
chr3_126077020_126077171	0.16	KLF15	Kruppel-like factor 15	810	0.63
chr10_74513820_74513971	0.16	RP11-354E23.5		12423	0.18
chr7_30721934_30722512	0.15	CRHR2	corticotropin releasing hormone receptor 2	91	0.98
chr8_145489549_145489796	0.15	SCXA	scleraxis homolog A (mouse)	877	0.39
chr8_145320438_145320697	0.15	SCXB	scleraxis homolog B (mouse)	950	0.47
chr21_27011889_27012538	0.15	JAM2	junctional adhesion molecule 2	303	0.91
chr2_27342148_27342407	0.15	CGREF1	cell growth regulator with EF-hand domain 1	282	0.79
chr2_101435204_101435829	0.15	NPAS2	neuronal PAS domain protein 2	1098	0.54
chr4_53727868_53728349	0.15	RASL11B	RAS-like, family 11, member B	349	0.9
chr19_45675642_45675793	0.15	TRAPPC6A	trafficking protein particle complex 6A	5768	0.11
chr22_29702254_29703430	0.15	GAS2L1	growth arrest-specific 2 like 1	171	0.91
chr16_75284494_75285397	0.15	BCAR1	breast cancer anti-estrogen resistance 1	100	0.96
chr9_137967884_137968035	0.15	OLFM1	olfactomedin 1	447	0.88
chr4_52917683_52918097	0.15	SPATA18	spermatogenesis associated 18	308	0.91
chr4_68904177_68904377	0.14	TMPRSS11GP	transmembrane protease, serine 11G, pseudogene	22791	0.16
chr22_45054428_45054579	0.14	PRR5	proline rich 5 (renal)	10090	0.23
chr19_8372502_8373304	0.14	CD320	CD320 molecule	331	0.8
chr5_76372662_76373578	0.14	ENSG00000238961	.	3276	0.17
chr3_134093862_134094013	0.14	AMOTL2	angiomotin like 2	177	0.96
chr9_131183467_131183728	0.14	CERCAM	cerebral endothelial cell adhesion molecule	837	0.44
chr6_134210328_134210483	0.14	TCF21	transcription factor 21	68	0.76
chr7_130578978_130579129	0.14	ENSG00000226380	.	16755	0.25
chr19_29590040_29590191	0.14	ENSG00000252272	.	97538	0.08
chr19_5294712_5294863	0.14	PTPRS	protein tyrosine phosphatase, receptor type, S	1524	0.49
chr9_72286759_72287117	0.14	APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	284	0.94
chr5_158518760_158518911	0.14	EBF1	early B-cell factor 1	7866	0.26
chr14_96342973_96343124	0.14	ENSG00000263357	.	25121	0.23
chr19_46270942_46271877	0.14	AC074212.5		236	0.49
chr17_6458496_6458984	0.14	PITPNM3	PITPNM family member 3	1040	0.49
chrX_57618390_57619431	0.14	ZXDB	zinc finger, X-linked, duplicated B	641	0.84
chr2_56150483_56150911	0.14	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	214	0.94
chr3_8810545_8810722	0.14	OXTR	oxytocin receptor	270	0.88
chr7_150758512_150758663	0.14	SLC4A2	solute carrier family 4 (anion exchanger), member 2	89	0.92
chr1_1448548_1448833	0.14	ATAD3A	ATPase family, AAA domain containing 3A	780	0.47
chr4_1075998_1076254	0.14	RNF212	ring finger protein 212	31188	0.1
chr12_121648551_121648807	0.14	P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	711	0.67
chr7_55087572_55088165	0.14	EGFR	epidermal growth factor receptor	1057	0.68
chr1_29448339_29449190	0.14	TMEM200B	transmembrane protein 200B	249	0.93
chr18_46149088_46149239	0.14	ENSG00000266276	.	47808	0.15
chr7_102555257_102555409	0.13	LRRC17	leucine rich repeat containing 17	1881	0.34
chr16_80972190_80972544	0.13	CMC2	C-x(9)-C motif containing 2	59897	0.09
chr16_2198732_2199283	0.13	RAB26	RAB26, member RAS oncogene family	382	0.61
chr12_132313557_132314091	0.13	MMP17	matrix metallopeptidase 17 (membrane-inserted)	739	0.63
chr17_48280882_48281058	0.13	COL1A1	collagen, type I, alpha 1	1977	0.21
chr5_172140268_172140466	0.13	CTB-79E8.2		15644	0.15
chr9_130739589_130739875	0.13	FAM102A	family with sequence similarity 102, member A	3060	0.15
chr14_105877952_105878277	0.13	RP11-521B24.3		7962	0.12
chr7_110732102_110732377	0.13	LRRN3	leucine rich repeat neuronal 3	1140	0.59
chr16_31548902_31549248	0.13	AHSP	alpha hemoglobin stabilizing protein	9777	0.11
chr19_30156409_30157288	0.13	PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	440	0.86
chr12_96183320_96183471	0.13	NTN4	netrin 4	331	0.86
chr7_1578236_1578521	0.13	MAFK	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K	34	0.97
chr1_165345218_165345646	0.13	LMX1A	LIM homeobox transcription factor 1, alpha	19480	0.23
chr9_4490575_4491197	0.13	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	442	0.88
chr10_85954746_85954956	0.13	CDHR1	cadherin-related family member 1	437	0.79
chr19_51161641_51162497	0.13	C19orf81	chromosome 19 open reading frame 81	9024	0.12
chr17_74025581_74025732	0.13	EVPL	envoplakin	2123	0.19
chr1_56656926_56657077	0.13	ENSG00000223307	.	186089	0.03
chr1_85248095_85248299	0.13	ENSG00000251899	.	10685	0.25
chr13_40176285_40177298	0.13	LHFP	lipoma HMGIC fusion partner	517	0.82
chr4_187025490_187026623	0.13	FAM149A	family with sequence similarity 149, member A	175	0.94
chr6_148664293_148664728	0.13	SASH1	SAM and SH3 domain containing 1	781	0.74
chr10_52751577_52751944	0.13	PRKG1	protein kinase, cGMP-dependent, type I	642	0.8
chr10_17495370_17496061	0.13	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	614	0.77
chr21_36042499_36043134	0.13	CLIC6	chloride intracellular channel 6	1128	0.59
chr17_75428865_75429016	0.13	SEPT9	septin 9	5902	0.16
chr12_123559968_123560341	0.13	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	488	0.8
chr8_131455067_131455631	0.13	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	557	0.87
chr5_41925427_41926188	0.13	FBXO4	F-box protein 4	404	0.85
chr8_37555995_37556200	0.13	ZNF703	zinc finger protein 703	2828	0.18
chr14_22955963_22956254	0.13	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	63	0.95
chr12_8852377_8852528	0.13	RIMKLB	ribosomal modification protein rimK-like family member B	10	0.98
chrX_132092102_132092291	0.13	HS6ST2	heparan sulfate 6-O-sulfotransferase 2	852	0.73
chr19_50861631_50862161	0.13	NAPSA	napsin A aspartic peptidase	6986	0.09
chr10_22764645_22765757	0.13	RP11-301N24.3		115100	0.05
chr7_5637806_5638004	0.12	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	3588	0.2
chr17_38600498_38600710	0.12	IGFBP4	insulin-like growth factor binding protein 4	891	0.5
chr10_35926379_35926659	0.12	ENSG00000264780	.	3661	0.21
chr10_3109322_3109496	0.12	PFKP	phosphofructokinase, platelet	303	0.94
chr6_43043530_43043730	0.12	PTK7	protein tyrosine kinase 7	376	0.67
chr14_33407702_33407902	0.12	NPAS3	neuronal PAS domain protein 3	647	0.84
chr9_133320745_133320993	0.12	ASS1	argininosuccinate synthase 1	490	0.76
chr2_217500083_217500256	0.12	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	2051	0.31
chrX_109675525_109675676	0.12	AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	7861	0.23
chr6_127836765_127837772	0.12	SOGA3	SOGA family member 3	491	0.85
chr12_113670561_113670712	0.12	TPCN1	two pore segment channel 1	7587	0.13
chr11_75943170_75943321	0.12	WNT11	wingless-type MMTV integration site family, member 11	21465	0.18
chr17_80054957_80055667	0.12	FASN	fatty acid synthase	896	0.37
chr2_63817542_63817693	0.12	MDH1	malate dehydrogenase 1, NAD (soluble)	1158	0.47
chr10_98272514_98273588	0.12	TLL2	tolloid-like 2	617	0.79
chr2_26785075_26785548	0.12	C2orf70	chromosome 2 open reading frame 70	139	0.96
chr9_35649649_35650491	0.12	SIT1	signaling threshold regulating transmembrane adaptor 1	867	0.32
chr1_32717802_32717953	0.12	LCK	lymphocyte-specific protein tyrosine kinase	1002	0.32
chr17_38614576_38614749	0.12	IGFBP4	insulin-like growth factor binding protein 4	14949	0.13
chr16_67197260_67198336	0.12	HSF4	heat shock transcription factor 4	510	0.52
chr17_80355063_80355214	0.12	RP13-20L14.4		4120	0.11
chr18_11571192_11571343	0.12	NPIPB1P	nuclear pore complex interacting protein family, member B1, pseudogene	68193	0.13
chr2_74643272_74643423	0.12	C2orf81	chromosome 2 open reading frame 81	363	0.72
chr17_71639222_71639967	0.12	SDK2	sidekick cell adhesion molecule 2	633	0.73
chr1_85527614_85527975	0.12	WDR63	WD repeat domain 63	201	0.94
chr10_79398606_79398757	0.12	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	328	0.92
chr7_64029651_64030186	0.12	ZNF680	zinc finger protein 680	6434	0.3
chr4_85419328_85419920	0.12	NKX6-1	NK6 homeobox 1	21	0.99
chr6_72596608_72597181	0.12	RIMS1	regulating synaptic membrane exocytosis 1	167	0.98
chr14_77227576_77228292	0.12	VASH1	vasohibin 1	598	0.75
chr20_56754532_56754733	0.12	C20orf85	chromosome 20 open reading frame 85	28672	0.17
chr7_128430672_128431008	0.12	CCDC136	coiled-coil domain containing 136	29	0.96
chr21_47518056_47518267	0.12	COL6A2	collagen, type VI, alpha 2	128	0.89
chr22_41957116_41957349	0.12	CSDC2	cold shock domain containing C2, RNA binding	465	0.74
chr22_20905991_20906349	0.12	MED15	mediator complex subunit 15	593	0.67
chr22_28838455_28839140	0.12	ENSG00000199797	.	139055	0.04
chr19_13136060_13136211	0.12	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	324	0.8
chr4_153168052_153168203	0.11	ENSG00000244544	.	17470	0.2
chr11_45201780_45202121	0.11	PRDM11	PR domain containing 11	1478	0.49
chr4_184021252_184021496	0.11	WWC2	WW and C2 domain containing 2	729	0.73
chr2_132218578_132219165	0.11	TUBA3D	tubulin, alpha 3d	14795	0.18
chr1_147717990_147718807	0.11	ENSG00000199879	.	17353	0.18
chr4_113739356_113739869	0.11	ANK2	ankyrin 2, neuronal	347	0.9
chr14_69727713_69728275	0.11	GALNT16	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16	986	0.63
chr11_1892431_1892936	0.11	LSP1	lymphocyte-specific protein 1	567	0.59
chr17_34121901_34122637	0.11	MMP28	matrix metallopeptidase 28	442	0.69
chr17_71641526_71641788	0.11	SDK2	sidekick cell adhesion molecule 2	1429	0.46

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.1	0.2	GO:0045759	negative regulation of action potential(GO:0045759)
0.1	0.2	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0002069	columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.1	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.1	GO:0000422	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.1	GO:1901881	positive regulation of protein depolymerization(GO:1901881)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.3	GO:0030238	male sex determination(GO:0030238)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.1	GO:0070307	lens fiber cell development(GO:0070307)
0.0	0.2	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.1	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0050919	negative chemotaxis(GO:0050919)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0010996	response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0	0.1	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.0	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0071875	adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.2	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.1	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.2	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
0.0	0.1	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0031620	regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.0	0.0	GO:0016198	axon choice point recognition(GO:0016198)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.3	GO:0016486	peptide hormone processing(GO:0016486)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.2	GO:0045987	positive regulation of smooth muscle contraction(GO:0045987)
0.0	0.0	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664)
0.0	0.1	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.2	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	0.0	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.2	GO:0008088	axo-dendritic transport(GO:0008088)
0.0	0.1	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.0	GO:0060430	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.4	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0	0.0	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0010665	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.0	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0048668	collateral sprouting(GO:0048668)
0.0	0.0	GO:0051580	positive regulation of dopamine secretion(GO:0033603) regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0	0.1	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.0	GO:0060897	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.1	GO:0007530	sex determination(GO:0007530)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.0	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.0	GO:0033087	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0060761	negative regulation of response to cytokine stimulus(GO:0060761)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	0.2	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.2	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.2	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.0	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.5	GO:0004954	prostanoid receptor activity(GO:0004954)
0.1	0.2	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.2	GO:0019215	intermediate filament binding(GO:0019215)
0.1	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.2	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.3	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.2	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.0	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0051380	norepinephrine binding(GO:0051380)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.4	GO:0045296	cadherin binding(GO:0045296)
0.0	0.5	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0043121	neurotrophin binding(GO:0043121) nerve growth factor binding(GO:0048406)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.0	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.1	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.0	GO:0004844	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0008556	potassium-transporting ATPase activity(GO:0008556)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.0	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions