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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZKSCAN3

Z-value: 1.48

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Transcription factors associated with ZKSCAN3

Gene Symbol	Gene ID	Gene Info
ZKSCAN3 Ensembl NCBI GeneCards UniProt	ENSG00000189298.9	ZKSCAN3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZKSCAN3	chr6_28317524_28317690	84	0.960724	0.08	8.3e-01	Click!
ZKSCAN3	chr6_28317691_28318186	211	0.915228	-0.04	9.1e-01	Click!

Activity of the ZKSCAN3 motif across conditions

Conditions sorted by the z-value of the ZKSCAN3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_56408975_56409725	1.69	MIR142	microRNA 142	519	0.63
chr17_76126911_76127107	1.48	TMC8	transmembrane channel-like 8	140	0.63
chrX_128914916_128915218	1.20	SASH3	SAM and SH3 domain containing 3	1107	0.52
chr5_118607055_118607314	1.15	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2735	0.27
chr20_56193926_56194226	1.10	ZBP1	Z-DNA binding protein 1	1374	0.49
chr14_76009252_76009829	1.08	BATF	basic leucine zipper transcription factor, ATF-like	20637	0.15
chr1_1148809_1149188	1.00	TNFRSF4	tumor necrosis factor receptor superfamily, member 4	514	0.56
chr11_3860110_3860464	0.96	RHOG	ras homolog family member G	1190	0.3
chr4_6918537_6918793	0.88	TBC1D14	TBC1 domain family, member 14	6690	0.19
chr2_136872491_136872642	0.85	CXCR4	chemokine (C-X-C motif) receptor 4	1247	0.6
chr16_70452884_70453127	0.84	ST3GAL2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	18464	0.11
chr20_826059_826564	0.80	FAM110A	family with sequence similarity 110, member A	544	0.82
chr3_9821738_9821889	0.75	CAMK1	calcium/calmodulin-dependent protein kinase I	10137	0.09
chr20_50158730_50159057	0.75	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	365	0.92
chr2_169103559_169103719	0.73	STK39	serine threonine kinase 39	1012	0.7
chr1_7763805_7764045	0.72	CAMTA1	calmodulin binding transcription activator 1	32543	0.17
chr14_24640773_24641022	0.70	REC8	REC8 meiotic recombination protein	165	0.84
chr3_43332584_43332867	0.70	SNRK	SNF related kinase	4647	0.21
chr1_211509571_211509738	0.70	TRAF5	TNF receptor-associated factor 5	9475	0.25
chr3_127392819_127392970	0.69	ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	59	0.97
chr13_30950896_30951047	0.68	KATNAL1	katanin p60 subunit A-like 1	69350	0.11
chr18_21601315_21601466	0.68	TTC39C	tetratricopeptide repeat domain 39C	4792	0.19
chr4_154448881_154449032	0.67	KIAA0922	KIAA0922	28092	0.22
chr17_45812399_45812645	0.67	TBX21	T-box 21	1912	0.27
chrY_22738367_22738527	0.66	EIF1AY	eukaryotic translation initiation factor 1A, Y-linked	767	0.8
chr4_42657844_42658977	0.66	ATP8A1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	700	0.59
chr9_20379288_20379439	0.64	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	3104	0.27
chr17_33640471_33640814	0.62	SLFN11	schlafen family member 11	39508	0.12
chr20_31069881_31070147	0.62	C20orf112	chromosome 20 open reading frame 112	1260	0.46
chr1_62862864_62863015	0.61	USP1	ubiquitin specific peptidase 1	39029	0.17
chr2_71292065_71292344	0.61	AC007040.8		331	0.79
chr11_46140422_46140573	0.60	PHF21A	PHD finger protein 21A	841	0.64
chr1_9690042_9690512	0.60	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	21513	0.15
chr19_42703347_42703984	0.59	ENSG00000265122	.	6435	0.1
chr3_81692511_81692662	0.59	GBE1	glucan (1,4-alpha-), branching enzyme 1	100194	0.09
chr2_152326029_152326180	0.59	NEB	nebulin	33839	0.18
chr14_94429340_94429491	0.59	ASB2	ankyrin repeat and SOCS box containing 2	5648	0.17
chr14_78108377_78108627	0.59	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	25386	0.16
chr8_22876543_22876783	0.59	RP11-875O11.1		185	0.92
chr6_30458735_30458886	0.59	HLA-E	major histocompatibility complex, class I, E	1566	0.31
chr9_71650379_71650667	0.58	FXN	frataxin	44	0.98
chr9_129485287_129485658	0.55	ENSG00000266403	.	4860	0.26
chr7_75267461_75267701	0.54	HIP1	huntingtin interacting protein 1	26420	0.17
chr11_58291916_58292352	0.53	OR5B21	olfactory receptor, family 5, subfamily B, member 21	16556	0.16
chr2_103035996_103036147	0.52	IL18RAP	interleukin 18 receptor accessory protein	75	0.96
chr16_14379797_14380077	0.52	ENSG00000201075	.	10575	0.18
chr2_198063557_198063736	0.51	ANKRD44	ankyrin repeat domain 44	884	0.43
chr10_97516050_97516539	0.51	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	580	0.8
chr10_121276029_121276279	0.49	RGS10	regulator of G-protein signaling 10	10835	0.24
chr12_66585349_66585521	0.49	IRAK3	interleukin-1 receptor-associated kinase 3	2398	0.25
chr9_34122956_34123107	0.48	DCAF12	DDB1 and CUL4 associated factor 12	2694	0.22
chr10_115613974_115614183	0.48	DCLRE1A	DNA cross-link repair 1A	64	0.82
chr1_226926024_226926994	0.48	ITPKB	inositol-trisphosphate 3-kinase B	355	0.91
chr12_49374311_49374525	0.48	WNT1	wingless-type MMTV integration site family, member 1	2020	0.12
chrX_153672104_153672338	0.48	FAM50A	family with sequence similarity 50, member A	252	0.79
chr8_66752287_66752671	0.47	PDE7A	phosphodiesterase 7A	1264	0.6
chr20_58515606_58515958	0.46	FAM217B	family with sequence similarity 217, member B	288	0.62
chr3_47028874_47029030	0.45	CCDC12	coiled-coil domain containing 12	5480	0.19
chr13_49787907_49788058	0.45	MLNR	motilin receptor	6492	0.24
chr21_47971505_47971656	0.45	ENSG00000272283	.	15871	0.17
chr2_191744870_191745300	0.45	GLS	glutaminase	468	0.79
chr21_34395985_34396161	0.45	OLIG2	oligodendrocyte lineage transcription factor 2	2080	0.33
chr3_122512790_122513032	0.44	HSPBAP1	HSPB (heat shock 27kDa) associated protein 1	240	0.82
chr22_50311854_50312054	0.44	CRELD2	cysteine-rich with EGF-like domains 2	139	0.51
chr19_45595083_45595471	0.44	PPP1R37	protein phosphatase 1, regulatory subunit 37	941	0.32
chr2_231533080_231533231	0.44	CAB39	calcium binding protein 39	44405	0.14
chr12_123372500_123372784	0.43	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)	2064	0.29
chr6_157970217_157970368	0.42	ENSG00000266617	.	20128	0.23
chr1_149294050_149294201	0.42	ENSG00000252105	.	7803	0.17
chr4_185741986_185742137	0.42	ACSL1	acyl-CoA synthetase long-chain family member 1	5127	0.2
chr1_185083987_185084138	0.41	TRMT1L	tRNA methyltransferase 1 homolog (S. cerevisiae)-like	24630	0.18
chr11_117198864_117199680	0.41	CEP164	centrosomal protein 164kDa	453	0.5
chr9_139000986_139001191	0.41	C9orf69	chromosome 9 open reading frame 69	9032	0.19
chr15_41624315_41624466	0.41	OIP5	Opa interacting protein 5	295	0.65
chr2_85107193_85107344	0.40	TRABD2A	TraB domain containing 2A	938	0.57
chr16_23689854_23690079	0.40	PLK1	polo-like kinase 1	177	0.92
chr14_50366151_50366383	0.40	ENSG00000251929	.	2401	0.2
chr6_158980808_158981008	0.40	TMEM181	transmembrane protein 181	23440	0.19
chr2_10548605_10548929	0.40	HPCAL1	hippocalcin-like 1	11380	0.19
chr17_29158612_29158825	0.39	ATAD5	ATPase family, AAA domain containing 5	270	0.86
chr1_180982153_180982304	0.39	STX6	syntaxin 6	9777	0.16
chr16_84801882_84802033	0.39	USP10	ubiquitin specific peptidase 10	84	0.98
chr12_8125010_8125161	0.39	ENSG00000206636	.	3770	0.2
chr7_35731550_35731936	0.39	HERPUD2	HERPUD family member 2	2433	0.31
chr8_21776103_21776686	0.39	XPO7	exportin 7	786	0.64
chr7_150178540_150178691	0.38	GIMAP8	GTPase, IMAP family member 8	30897	0.13
chr19_23427286_23427437	0.38	ZNF724P	zinc finger protein 724, pseudogene	5801	0.26
chr8_37754904_37755445	0.38	RAB11FIP1	RAB11 family interacting protein 1 (class I)	1798	0.27
chrX_144516660_144516811	0.38	SPANXN1	SPANX family, member N1	188387	0.03
chr16_27326766_27327107	0.38	IL4R	interleukin 4 receptor	1623	0.4
chr12_77060372_77060523	0.37	ZDHHC17	zinc finger, DHHC-type containing 17	96921	0.08
chr15_91428804_91428955	0.37	FES	feline sarcoma oncogene	603	0.56
chr2_42333200_42333351	0.37	PKDCC	protein kinase domain containing, cytoplasmic	58115	0.11
chr19_7198675_7198826	0.37	INSR	insulin receptor	30761	0.15
chr6_90538863_90539246	0.37	ENSG00000238747	.	6040	0.17
chr5_14581323_14581785	0.36	FAM105A	family with sequence similarity 105, member A	330	0.92
chr11_125773182_125774068	0.36	PUS3	pseudouridylate synthase 3	509	0.49
chr7_26564902_26565053	0.36	KIAA0087	KIAA0087	13430	0.27
chr12_113573231_113573417	0.36	RASAL1	RAS protein activator like 1 (GAP1 like)	15	0.96
chr12_7064003_7064154	0.36	PTPN6	protein tyrosine phosphatase, non-receptor type 6	3540	0.07
chr15_83777071_83777287	0.36	TM6SF1	transmembrane 6 superfamily member 1	716	0.58
chr7_92464516_92465198	0.35	AC002454.1		940	0.44
chr17_75451832_75452118	0.35	SEPT9	septin 9	473	0.77
chr1_153204493_153204644	0.35	PRR9	proline rich 9	14508	0.12
chr12_104682714_104682980	0.35	TXNRD1	thioredoxin reductase 1	174	0.95
chr8_53851957_53852159	0.35	NPBWR1	neuropeptides B/W receptor 1	1067	0.63
chr12_105379814_105380296	0.35	C12orf45	chromosome 12 open reading frame 45	33	0.98
chr11_73091522_73091673	0.35	RELT	RELT tumor necrosis factor receptor	3884	0.17
chr19_2702225_2702378	0.34	GNG7	guanine nucleotide binding protein (G protein), gamma 7	406	0.76
chr19_9649363_9649620	0.34	ZNF426	zinc finger protein 426	188	0.94
chr1_149679650_149680105	0.34	FAM231D	family with sequence similarity 231, member D	3899	0.14
chr1_26485721_26485872	0.34	FAM110D	family with sequence similarity 110, member D	285	0.83
chr9_131486813_131486981	0.34	RP11-545E17.3		173	0.76
chr6_32935556_32936303	0.34	BRD2	bromodomain containing 2	508	0.51
chr10_86559929_86560080	0.34	ENSG00000238469	.	63017	0.16
chr10_104953208_104953414	0.33	NT5C2	5'-nucleotidase, cytosolic II	255	0.93
chr19_50269466_50269673	0.33	AP2A1	adaptor-related protein complex 2, alpha 1 subunit	656	0.43
chr10_98346955_98347114	0.33	TM9SF3	transmembrane 9 superfamily member 3	175	0.95
chr17_27942135_27942628	0.33	CORO6	coronin 6	2754	0.11
chr1_226842452_226842603	0.33	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	4844	0.24
chr9_115095390_115095852	0.32	PTBP3	polypyrimidine tract binding protein 3	237	0.93
chr11_10826698_10826955	0.32	EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	2183	0.2
chr19_18209757_18210181	0.32	IL12RB1	interleukin 12 receptor, beta 1	215	0.88
chr14_22591595_22591746	0.32	ENSG00000238634	.	19217	0.26
chr17_54912094_54912323	0.32	DGKE	diacylglycerol kinase, epsilon 64kDa	119	0.92
chr17_58041207_58042016	0.31	RNFT1	ring finger protein, transmembrane 1	469	0.76
chr4_6200889_6201238	0.31	JAKMIP1	janus kinase and microtubule interacting protein 1	1219	0.6
chr3_178866443_178867773	0.31	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	207	0.94
chr17_40729951_40730261	0.31	PSMC3IP	PSMC3 interacting protein	257	0.81
chr4_152787665_152787816	0.31	ENSG00000253077	.	105025	0.07
chr6_90061473_90061759	0.30	UBE2J1	ubiquitin-conjugating enzyme E2, J1	951	0.59
chr14_89925846_89925997	0.30	FOXN3	forkhead box N3	34474	0.15
chr12_7995756_7996489	0.30	ENSG00000222978	.	3762	0.15
chr20_47365732_47365883	0.30	ENSG00000251876	.	9822	0.28
chr19_21646219_21646922	0.30	ZNF429	zinc finger protein 429	41796	0.16
chr7_142161599_142161750	0.30	PRSS3P3	protease, serine, 3 pseudogene 3	172065	0.03
chr14_24550083_24550870	0.29	NRL	neural retina leucine zipper	661	0.47
chr3_71730862_71731013	0.29	EIF4E3	eukaryotic translation initiation factor 4E family member 3	43589	0.15
chr19_59049656_59050353	0.29	ZBTB45	zinc finger and BTB domain containing 45	274	0.78
chr1_212340351_212340502	0.29	ENSG00000252879	.	67408	0.09
chr3_171825160_171825429	0.29	FNDC3B	fibronectin type III domain containing 3B	19470	0.26
chr1_150536035_150536186	0.29	ADAMTSL4-AS1	ADAMTSL4 antisense RNA 1	2141	0.14
chr16_89043094_89043288	0.29	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	210	0.92
chr6_32159535_32159686	0.29	GPSM3	G-protein signaling modulator 3	1035	0.26
chr17_4336857_4337447	0.29	SPNS3	spinster homolog 3 (Drosophila)	67	0.97
chr20_5584278_5584429	0.28	GPCPD1	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	7319	0.28
chr16_30486681_30486832	0.28	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1434	0.16
chr11_134200417_134200568	0.28	GLB1L2	galactosidase, beta 1-like 2	1276	0.47
chr17_14332143_14332294	0.28	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	127818	0.06
chr2_106388828_106388979	0.28	NCK2	NCK adaptor protein 2	26715	0.24
chr19_18606740_18606891	0.28	ELL	elongation factor RNA polymerase II	20072	0.09
chr15_65476466_65477266	0.28	CLPX	caseinolytic mitochondrial matrix peptidase chaperone subunit	44	0.97
chr13_41576254_41576405	0.28	ELF1	E74-like factor 1 (ets domain transcription factor)	17121	0.19
chr4_184312949_184313100	0.27	ENSG00000263395	.	7318	0.18
chr11_75063727_75063930	0.27	ARRB1	arrestin, beta 1	955	0.48
chr5_1501743_1501894	0.27	LPCAT1	lysophosphatidylcholine acyltransferase 1	22274	0.2
chr5_171061425_171061576	0.27	ENSG00000264303	.	136034	0.04
chr22_21024096_21024247	0.27	ENSG00000264718	.	12849	0.14
chr1_28415312_28415525	0.27	EYA3	eyes absent homolog 3 (Drosophila)	211	0.92
chr11_125461662_125462346	0.27	STT3A	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)	397	0.49
chr1_161185105_161185306	0.27	FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	118	0.89
chr7_75543939_75544219	0.26	POR	P450 (cytochrome) oxidoreductase	318	0.58
chr6_32144901_32145530	0.26	AGPAT1	1-acylglycerol-3-phosphate O-acyltransferase 1	113	0.87
chr2_240207404_240207640	0.26	ENSG00000265215	.	19635	0.17
chr1_225966293_225966491	0.26	SRP9	signal recognition particle 9kDa	755	0.6
chr18_47003055_47003217	0.26	RP11-110H1.4		9383	0.08
chr10_105667946_105668135	0.26	OBFC1	oligonucleotide/oligosaccharide-binding fold containing 1	9387	0.18
chr9_132647660_132648047	0.26	FNBP1	formin binding protein 1	33736	0.12
chr6_44042101_44042381	0.25	RP5-1120P11.1		148	0.95
chr1_233463556_233464041	0.25	MLK4	Mitogen-activated protein kinase kinase kinase MLK4	284	0.94
chr15_66993020_66993328	0.25	SMAD6	SMAD family member 6	1392	0.51
chr21_34671674_34671958	0.25	IFNAR1	interferon (alpha, beta and omega) receptor 1	24918	0.13
chr6_126067758_126068417	0.25	HEY2	hes-related family bHLH transcription factor with YRPW motif 2	723	0.57
chr1_67518540_67519349	0.25	SLC35D1	solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1	214	0.95
chr1_22351357_22351739	0.25	ENSG00000201273	.	14070	0.09
chrX_39953289_39953491	0.25	BCOR	BCL6 corepressor	3266	0.39
chr16_30393182_30393494	0.25	SEPT1	septin 1	414	0.64
chr8_101320634_101321676	0.25	RNF19A	ring finger protein 19A, RBR E3 ubiquitin protein ligase	599	0.79
chr12_131246546_131246697	0.25	RIMBP2	RIMS binding protein 2	45795	0.14
chr17_67322489_67323211	0.25	ABCA5	ATP-binding cassette, sub-family A (ABC1), member 5	381	0.89
chr2_216945952_216946469	0.25	PECR	peroxisomal trans-2-enoyl-CoA reductase	329	0.53
chr7_8181769_8181920	0.25	ENSG00000265212	.	12808	0.21
chr1_226593332_226593483	0.25	PARP1	poly (ADP-ribose) polymerase 1	2276	0.33
chr7_155089675_155090099	0.24	INSIG1	insulin induced gene 1	288	0.92
chrX_153775545_153775808	0.24	G6PD	glucose-6-phosphate dehydrogenase	96	0.49
chr6_143165995_143166218	0.24	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	7922	0.29
chr7_75796315_75796558	0.24	AC005077.5		6615	0.18
chr3_71773124_71773375	0.24	EIF4E3	eukaryotic translation initiation factor 4E family member 3	1277	0.5
chr1_101749663_101749814	0.24	RP4-575N6.5		41024	0.13
chr9_95791041_95791204	0.24	FGD3	FYVE, RhoGEF and PH domain containing 3	13780	0.18
chrX_117631127_117631452	0.24	DOCK11	dedicator of cytokinesis 11	1417	0.52
chr17_72463483_72463716	0.24	CD300A	CD300a molecule	598	0.68
chr12_124873885_124874250	0.23	NCOR2	nuclear receptor corepressor 2	697	0.79
chr5_77160779_77160930	0.23	TBCA	tubulin folding cofactor A	3750	0.36
chr19_17622493_17622725	0.23	PGLS	6-phosphogluconolactonase	65	0.94
chr1_149898902_149899634	0.23	SF3B4	splicing factor 3b, subunit 4, 49kDa	215	0.86
chr3_182511875_182512794	0.23	ATP11B	ATPase, class VI, type 11B	1043	0.43
chr2_28824878_28825070	0.23	PLB1	phospholipase B1	188	0.96
chr10_89628293_89628531	0.23	KLLN	killin, p53-regulated DNA replication inhibitor	5218	0.15
chr17_74489731_74490033	0.23	RHBDF2	rhomboid 5 homolog 2 (Drosophila)	598	0.59

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0015917	aminophospholipid transport(GO:0015917)
0.1	0.6	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.1	0.6	GO:0090201	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.1	0.6	GO:0051024	positive regulation of immunoglobulin secretion(GO:0051024)
0.1	0.3	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1	0.2	GO:0016576	histone dephosphorylation(GO:0016576)
0.1	0.5	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.2	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.1	0.3	GO:0072540	T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.1	0.4	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1	0.2	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	0.3	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.1	0.6	GO:0007141	male meiosis I(GO:0007141)
0.1	0.2	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.1	0.2	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1	0.3	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0021780	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.4	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0	0.5	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0006168	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.0	GO:0051569	regulation of histone methylation(GO:0031060) regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.2	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0010826	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.2	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.2	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.7	GO:0030890	positive regulation of B cell proliferation(GO:0030890)
0.0	0.1	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0061054	dermatome development(GO:0061054)
0.0	0.1	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.5	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.1	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.2	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.2	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.1	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.3	GO:0002209	behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.3	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.3	GO:1904377	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.2	GO:0010745	negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0	0.1	GO:0051299	centrosome separation(GO:0051299)
0.0	0.1	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.3	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.3	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0	0.0	GO:0051446	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.1	GO:0043011	myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0010935	macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.2	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.3	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.3	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.1	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.0	GO:0022038	cerebral cortex radial glia guided migration(GO:0021801) layer formation in cerebral cortex(GO:0021819) telencephalon glial cell migration(GO:0022030) corpus callosum development(GO:0022038)
0.0	0.3	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0045117	azole transport(GO:0045117)
0.0	0.2	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.0	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.1	GO:0032232	negative regulation of actin filament bundle assembly(GO:0032232)
0.0	0.3	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.1	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.0	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.0	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.9	GO:0030330	DNA damage response, signal transduction by p53 class mediator(GO:0030330)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	0.2	GO:0007379	segment specification(GO:0007379)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.0	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.0	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.0	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.1	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	0.0	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.0	GO:1903077	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0042640	anagen(GO:0042640)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.2	GO:0019835	cytolysis(GO:0019835)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0000800	lateral element(GO:0000800)
0.1	0.4	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	0.4	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.1	0.4	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.3	GO:0010369	chromocenter(GO:0010369)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.5	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.2	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0033391	chromatoid body(GO:0033391)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.7	GO:0000922	spindle pole(GO:0000922)
0.0	0.2	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.5	GO:0005814	centriole(GO:0005814)
0.0	0.0	GO:0001739	sex chromatin(GO:0001739)
0.0	0.7	GO:0031902	late endosome membrane(GO:0031902)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.3	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.2	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.0	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.1	GO:0005719	nuclear euchromatin(GO:0005719)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.6	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.5	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.1	0.2	GO:0016972	thiol oxidase activity(GO:0016972)
0.1	0.2	GO:0019863	IgE binding(GO:0019863)
0.1	0.4	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.1	0.5	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.1	0.3	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.1	0.3	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.6	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.4	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.2	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.3	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.2	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.5	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.3	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.7	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.2	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.5	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.2	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	1.0	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.2	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.2	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.4	GO:0019003	GDP binding(GO:0019003)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.6	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	0.0	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.2	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.7	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.2	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.0	GO:0046980	tapasin binding(GO:0046980)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.9	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.2	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.4	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.4	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.7	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.6	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.3	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.7	PID ATR PATHWAY	ATR signaling pathway
0.0	0.0	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.2	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.0	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	0.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.2	SIG CD40PATHWAYMAP	Genes related to CD40 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.8	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	1.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.4	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.4	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.1	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.0	0.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.0	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.4	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.6	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.3	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	0.1	REACTOME OPSINS	Genes involved in Opsins
0.0	0.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.4	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21