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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for ZNF143

Z-value: 1.50

Motif logo

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Transcription factors associated with ZNF143

Gene Symbol Gene ID Gene Info
ZNF143
ENSG00000166478.5 zinc finger protein 143

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_9548903_9549060ZNF143149370.157316-0.636.6e-02Click!
chr11_9510814_9510966ZNF143231540.139994-0.551.3e-01Click!
chr11_9511154_9511374ZNF143227800.140892-0.482.0e-01Click!
chr11_9482658_9482912ZNF1431810.8628630.432.5e-01Click!
chr11_9555045_9555196ZNF143210760.1429930.393.0e-01Click!

Activity of the ZNF143 motif across conditions

Conditions sorted by the z-value of the ZNF143 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_135089555_135089795 1.46 ADAM8
 ADAM metallopeptidase domain 8
 679
 0.52
chr19_48833249_48833485 0.76 EMP3
 epithelial membrane protein 3
 4502
 0.13
chr2_42599068_42599219 0.75 COX7A2L
 cytochrome c oxidase subunit VIIa polypeptide 2 like
 2993
 0.32
chr18_21464195_21464346 0.74 LAMA3
 laminin, alpha 3
 467
 0.84
chr7_150755256_150755900 0.73 CDK5
 cyclin-dependent kinase 5
 39
 0.77
chr17_43302789_43303077 0.63 CTD-2020K17.1
3344
 0.12
chrX_152200996_152201209 0.59 PNMA3
 paraneoplastic Ma antigen 3
 23664
 0.12
chr22_20067197_20067578 0.56 DGCR8
 DGCR8 microprocessor complex subunit
 368
 0.7
chr10_74095282_74095433 0.56 DNAJB12
 DnaJ (Hsp40) homolog, subfamily B, member 12
 9362
 0.19
chr19_17515989_17516450 0.54 BST2
 bone marrow stromal cell antigen 2
 238
 0.54
chr2_2617005_2617869 0.52 MYT1L
 myelin transcription factor 1-like
 282471
 0.01
chr2_74756873_74757049 0.52 AUP1
 ancient ubiquitous protein 1
 105
 0.55
chr17_56410837_56411117 0.52 MIR142
 microRNA 142
 1108
 0.32
chr19_10381757_10382103 0.51 ICAM1
 intercellular adhesion molecule 1
 134
 0.89
chr19_1407342_1407493 0.50 DAZAP1
 DAZ associated protein 1
 151
 0.88
chr11_2550000_2550151 0.49 KCNQ1
 potassium voltage-gated channel, KQT-like subfamily, member 1
 66958
 0.09
chr8_145734147_145734421 0.48 MFSD3
 major facilitator superfamily domain containing 3
 173
 0.83
chr12_53894777_53895686 0.47 TARBP2
 TAR (HIV-1) RNA binding protein 2
 150
 0.79
chr9_95826666_95826817 0.47 SUSD3
 sushi domain containing 3
 4641
 0.2
chr1_6479504_6479655 0.45 HES2
 hes family bHLH transcription factor 2
 384
 0.76
chr2_242556723_242557374 0.45 THAP4
 THAP domain containing 4
 132
 0.94
chr11_809579_809818 0.45 RPLP2
 ribosomal protein, large, P2
 51
 0.91
chr17_76250693_76250844 0.44 TMEM235
 transmembrane protein 235
 22646
 0.12
chr2_74669340_74669491 0.44 RTKN
 rhotekin
 389
 0.66
chr10_124134109_124134260 0.44 PLEKHA1
 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
 28
 0.98
chr2_26100038_26101197 0.44 ASXL2
 additional sex combs like 2 (Drosophila)
 718
 0.76
chr1_939046_939197 0.44 HES4
 hes family bHLH transcription factor 4
 3569
 0.11
chr7_6199542_6199693 0.43 CYTH3
 cytohesin 3
 13089
 0.14
chr21_45579276_45579734 0.43 AP001055.1
14075
 0.13
chr19_2562679_2562830 0.42 CTC-265F19.2
49106
 0.09
chrX_49042899_49043187 0.41 PRICKLE3
 prickle homolog 3 (Drosophila)
 198
 0.86
chr7_45076135_45076286 0.41 CCM2
 cerebral cavernous malformation 2
 8939
 0.15
chr14_36295319_36295470 0.41 BRMS1L
 breast cancer metastasis-suppressor 1-like
 130
 0.86
chr10_73532392_73533248 0.40 C10orf54
 chromosome 10 open reading frame 54
 435
 0.83
chr2_178417541_178417760 0.40 TTC30B
 tetratricopeptide repeat domain 30B
 92
 0.97
chr6_31802179_31802624 0.39 C6orf48
 chromosome 6 open reading frame 48
 3
 0.87
chr19_36398415_36398818 0.39 TYROBP
 TYRO protein tyrosine kinase binding protein
 533
 0.58
chr2_106362063_106362974 0.39 NCK2
 NCK adaptor protein 2
 330
 0.94
chr3_69591746_69591897 0.38 FRMD4B
 FERM domain containing 4B
 87
 0.99
chr8_141517648_141517821 0.38 CTA-204B4.2
408
 0.85
chr19_55629138_55629447 0.38 PPP1R12C
 protein phosphatase 1, regulatory subunit 12C
 365
 0.75
chr16_84582878_84583147 0.38 TLDC1
 TBC/LysM-associated domain containing 1
 4627
 0.21
chr13_41768167_41768864 0.38 KBTBD7
 kelch repeat and BTB (POZ) domain containing 7
 187
 0.94
chr5_1004071_1004222 0.38 ENSG00000221244
 .
 156
 0.93
chr10_46168316_46168717 0.37 ZFAND4
 zinc finger, AN1-type domain 4
 288
 0.92
chr12_110906550_110906725 0.37 GPN3
 GPN-loop GTPase 3
 111
 0.83
chr17_80260833_80260984 0.37 CD7
 CD7 molecule
 14520
 0.1
chr8_142413039_142413204 0.37 CTD-3064M3.4
10447
 0.12
chr1_26868114_26868336 0.36 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
 1378
 0.34
chr3_57038475_57038626 0.36 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 27147
 0.18
chrX_147462854_147463013 0.36 AC002368.4
119202
 0.06
chr19_4791521_4791672 0.36 FEM1A
 fem-1 homolog a (C. elegans)
 132
 0.93
chr3_48230084_48230363 0.36 CDC25A
 cell division cycle 25A
 331
 0.83
chr1_200008337_200008553 0.35 NR5A2
 nuclear receptor subfamily 5, group A, member 2
 3272
 0.23
chr1_27989345_27989660 0.35 RP11-288L9.4
6477
 0.12
chr19_13274647_13274798 0.35 CTC-250I14.6
9715
 0.11
chr14_81938636_81938919 0.35 STON2
 stonin 2
 35968
 0.21
chr14_91096638_91096789 0.35 RP11-1078H9.5
12269
 0.18
chr19_2093663_2094074 0.35 MOB3A
 MOB kinase activator 3A
 2401
 0.16
chr1_154986335_154986486 0.35 ZBTB7B
 zinc finger and BTB domain containing 7B
 514
 0.55
chr8_144634608_144634759 0.35 GSDMD
 gasdermin D
 694
 0.41
chr15_41913046_41914152 0.34 MGA
 MGA, MAX dimerization protein
 135
 0.96
chr22_45706838_45707043 0.34 FAM118A
 family with sequence similarity 118, member A
 935
 0.58
chr1_28974832_28975188 0.34 ENSG00000270103
 .
 102
 0.95
chr3_182879726_182880740 0.34 LAMP3
 lysosomal-associated membrane protein 3
 430
 0.86
chr7_140098327_140098552 0.33 SLC37A3
 solute carrier family 37, member 3
 90
 0.96
chr20_5100236_5100597 0.33 PCNA
 proliferating cell nuclear antigen
 256
 0.85
chr1_2165353_2165549 0.33 SKI
 v-ski avian sarcoma viral oncogene homolog
 5317
 0.14
chr19_48673594_48673912 0.32 LIG1
 ligase I, DNA, ATP-dependent
 107
 0.61
chr19_5255691_5255842 0.32 PTPRS
 protein tyrosine phosphatase, receptor type, S
 30408
 0.19
chr16_279456_279667 0.32 LUC7L
 LUC7-like (S. cerevisiae)
 99
 0.93
chr17_81047529_81047808 0.31 METRNL
 meteorin, glial cell differentiation regulator-like
 4326
 0.27
chr3_5028227_5029021 0.31 BHLHE40-AS1
 BHLHE40 antisense RNA 1
 6978
 0.21
chr8_21754477_21754628 0.31 DOK2
 docking protein 2, 56kDa
 16622
 0.18
chr17_28927099_28927365 0.31 SMURF2P1
 SMAD specific E3 ubiquitin protein ligase 2 pseudogene 1
 651
 0.67
chr22_39637649_39637800 0.31 PDGFB
 platelet-derived growth factor beta polypeptide
 589
 0.68
chr11_64005411_64005562 0.31 VEGFB
 vascular endothelial growth factor B
 478
 0.51
chr14_39901349_39901640 0.31 FBXO33
 F-box protein 33
 176
 0.97
chr16_70487949_70488475 0.31 FUK
 fucokinase
 112
 0.94
chr19_44331131_44331711 0.31 ZNF283
 zinc finger protein 283
 23
 0.53
chr19_3801497_3801822 0.31 MATK
 megakaryocyte-associated tyrosine kinase
 138
 0.93
chr5_175958496_175958647 0.30 RNF44
 ring finger protein 44
 925
 0.45
chr20_1446772_1447463 0.29 NSFL1C
 NSFL1 (p97) cofactor (p47)
 356
 0.84
chr6_150070946_150071995 0.29 PCMT1
 protein-L-isoaspartate (D-aspartate) O-methyltransferase
 290
 0.87
chr19_49004084_49004235 0.29 LMTK3
 lemur tyrosine kinase 3
 10902
 0.1
chr7_112090576_112091250 0.29 IFRD1
 interferon-related developmental regulator 1
 162
 0.96
chr6_42332930_42333081 0.29 ENSG00000221252
 .
 47129
 0.14
chr9_131012193_131012363 0.29 ENSG00000264823
 .
 4969
 0.09
chr11_93394564_93394780 0.28 KIAA1731
 KIAA1731
 133
 0.94
chr19_17517338_17517489 0.28 MVB12A
 multivesicular body subunit 12A
 459
 0.54
chr12_6570769_6570920 0.28 VAMP1
 vesicle-associated membrane protein 1 (synaptobrevin 1)
 8967
 0.09
chr19_17634183_17634515 0.28 FAM129C
 family with sequence similarity 129, member C
 239
 0.85
chr22_37542366_37542517 0.28 IL2RB
 interleukin 2 receptor, beta
 3589
 0.14
chr8_27631821_27631972 0.28 ESCO2
 establishment of sister chromatid cohesion N-acetyltransferase 2
 7
 0.92
chrX_48814848_48815217 0.28 OTUD5
 OTU domain containing 5
 139
 0.9
chr4_6675763_6675979 0.28 AC093323.1
 Uncharacterized protein
 18318
 0.14
chr9_130497113_130497635 0.28 TOR2A
 torsin family 2, member A
 197
 0.88
chr19_36618863_36619073 0.28 CAPNS1
 calpain, small subunit 1
 11509
 0.09
chr12_96429136_96429440 0.28 LTA4H
 leukotriene A4 hydrolase
 151
 0.95
chr17_62658617_62658986 0.28 SMURF2
 SMAD specific E3 ubiquitin protein ligase 2
 615
 0.77
chr1_53164097_53164296 0.28 COA7
 cytochrome c oxidase assembly factor 7
 158
 0.94
chr8_41907411_41908748 0.27 KAT6A
 K(lysine) acetyltransferase 6A
 1426
 0.43
chr15_75315646_75315949 0.27 PPCDC
 phosphopantothenoylcysteine decarboxylase
 99
 0.96
chr16_89042188_89042390 0.27 CBFA2T3
 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
 1112
 0.45
chr7_63386955_63387300 0.27 ENSG00000265017
 .
 87
 0.98
chr10_1696776_1696927 0.27 ADARB2
 adenosine deaminase, RNA-specific, B2 (non-functional)
 82819
 0.11
chr7_72936423_72936636 0.27 BAZ1B
 bromodomain adjacent to zinc finger domain, 1B
 73
 0.96
chr15_86337104_86338160 0.27 KLHL25
 kelch-like family member 25
 468
 0.73
chr1_181451777_181451943 0.27 CACNA1E
 calcium channel, voltage-dependent, R type, alpha 1E subunit
 856
 0.76
chrX_118823023_118823250 0.27 SEPT6
 septin 6
 3656
 0.22
chr7_72439858_72440009 0.27 TRIM74
 tripartite motif containing 74
 64
 0.95
chr16_88366626_88367008 0.26 ZNF469
 zinc finger protein 469
 127062
 0.05
chr10_79613508_79613659 0.26 AL391421.1
 Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964
 13050
 0.18
chr9_38621823_38622122 0.26 FAM201A
 family with sequence similarity 201, member A
 887
 0.5
chr1_117594372_117594685 0.26 RP11-27K13.3
7584
 0.17
chr17_8076861_8077643 0.26 ENSG00000200463
 .
 347
 0.7
chr17_26874549_26874726 0.26 UNC119
 unc-119 homolog (C. elegans)
 1780
 0.17
chr1_16470291_16470442 0.26 RP11-276H7.2
11340
 0.12
chr2_240187102_240187645 0.26 ENSG00000265215
 .
 39784
 0.13
chr7_26191457_26191700 0.26 NFE2L3
 nuclear factor, erythroid 2-like 3
 282
 0.91
chr15_94406450_94406737 0.26 ENSG00000222409
 .
 33663
 0.25
chr19_39811900_39812051 0.25 CTC-246B18.8
477
 0.64
chr18_23670660_23670942 0.25 SS18
 synovial sarcoma translocation, chromosome 18
 64
 0.98
chr19_45393848_45394047 0.25 TOMM40
 translocase of outer mitochondrial membrane 40 homolog (yeast)
 121
 0.58
chr14_103801113_103802028 0.25 EIF5
 eukaryotic translation initiation factor 5
 284
 0.87
chr2_96782390_96782846 0.25 ADRA2B
 adrenoceptor alpha 2B
 634
 0.68
chr5_176944022_176944323 0.25 DDX41
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
 255
 0.85
chr1_32645201_32645477 0.25 TXLNA
 taxilin alpha
 52
 0.94
chr7_134670907_134671205 0.25 AGBL3
 ATP/GTP binding protein-like 3
 203
 0.96
chr17_9330961_9331112 0.25 AC087501.1
24478
 0.18
chr14_75926184_75926335 0.25 JDP2
 Jun dimerization protein 2
 27422
 0.16
chr12_56498056_56498239 0.25 PA2G4
 proliferation-associated 2G4, 38kDa
 44
 0.92
chr19_49972030_49972206 0.25 FLT3LG
 fms-related tyrosine kinase 3 ligand
 5367
 0.06
chr11_112097343_112097611 0.24 PTS
 6-pyruvoyltetrahydropterin synthase
 322
 0.82
chr22_37937663_37937814 0.24 RP5-1177I5.3
8295
 0.12
chr11_119562641_119562792 0.24 ENSG00000199217
 .
 35695
 0.14
chrX_132091720_132091956 0.24 HS6ST2
 heparan sulfate 6-O-sulfotransferase 2
 494
 0.87
chr1_151226917_151227146 0.24 PSMD4
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
 148
 0.91
chr22_42696607_42696758 0.24 TCF20
 transcription factor 20 (AR1)
 42940
 0.14
chr1_28195302_28195741 0.24 THEMIS2
 thymocyte selection associated family member 2
 3534
 0.14
chr14_91868738_91869034 0.23 CCDC88C
 coiled-coil domain containing 88C
 14804
 0.23
chr1_207243797_207243948 0.23 PFKFB2
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
 5523
 0.14
chr3_9773477_9774131 0.23 BRPF1
 bromodomain and PHD finger containing, 1
 332
 0.81
chr12_89747023_89747227 0.23 DUSP6
 dual specificity phosphatase 6
 77
 0.98
chr9_95794200_95794351 0.23 FGD3
 FYVE, RhoGEF and PH domain containing 3
 16933
 0.17
chr3_158288936_158289364 0.23 MLF1
 myeloid leukemia factor 1
 100
 0.76
chr19_13952735_13952973 0.23 ENSG00000207980
 .
 5381
 0.08
chr1_1689799_1689950 0.23 NADK
 NAD kinase
 140
 0.94
chr21_17959283_17959568 0.23 ENSG00000207863
 .
 3132
 0.31
chr4_40058976_40059529 0.23 N4BP2
 NEDD4 binding protein 2
 696
 0.68
chr9_139581476_139581762 0.23 AGPAT2
 1-acylglycerol-3-phosphate O-acyltransferase 2
 229
 0.84
chr18_3447400_3448025 0.23 TGIF1
 TGFB-induced factor homeobox 1
 105
 0.97
chr15_72522652_72522803 0.23 PKM
 pyruvate kinase, muscle
 664
 0.65
chr22_37618634_37618785 0.23 SSTR3
 somatostatin receptor 3
 10347
 0.13
chr3_150126096_150126425 0.23 TSC22D2
 TSC22 domain family, member 2
 138
 0.98
chr19_1260409_1260809 0.22 CIRBP
 cold inducible RNA binding protein
 546
 0.56
chr5_142177952_142178103 0.22 ARHGAP26
 Rho GTPase activating protein 26
 25745
 0.22
chr6_36164778_36164969 0.22 RP1-179N16.6
107
 0.53
chr19_45257252_45257704 0.22 BCL3
 B-cell CLL/lymphoma 3
 2900
 0.15
chr15_90447970_90448121 0.22 C15orf38
 chromosome 15 open reading frame 38
 870
 0.42
chr7_65579625_65579846 0.22 CRCP
 CGRP receptor component
 78
 0.97
chr4_6687752_6687903 0.22 AC093323.1
 Uncharacterized protein
 6362
 0.15
chrX_65234090_65234241 0.22 ENSG00000207939
 .
 4547
 0.23
chr11_73358513_73358664 0.22 PLEKHB1
 pleckstrin homology domain containing, family B (evectins) member 1
 6
 0.98
chr11_18720549_18721118 0.22 TMEM86A
 transmembrane protein 86A
 495
 0.74
chr2_223169880_223170456 0.22 CCDC140
 coiled-coil domain containing 140
 2471
 0.27
chr4_1581349_1582263 0.22 FAM53A
 family with sequence similarity 53, member A
 75329
 0.08
chr16_21170219_21170819 0.22 DNAH3
 dynein, axonemal, heavy chain 3
 243
 0.71
chr6_159464305_159464462 0.22 TAGAP
 T-cell activation RhoGTPase activating protein
 1667
 0.38
chr7_75024883_75025034 0.22 TRIM73
 tripartite motif containing 73
 55
 0.84
chr1_6532288_6532439 0.22 TNFRSF25
 tumor necrosis factor receptor superfamily, member 25
 6108
 0.12
chr17_40440128_40440459 0.22 STAT5A
 signal transducer and activator of transcription 5A
 194
 0.91
chr5_131831286_131831908 0.21 IRF1
 interferon regulatory factor 1
 5107
 0.15
chr1_231917497_231917650 0.21 ENSG00000222986
 .
 111192
 0.06
chr1_27248269_27248533 0.21 NUDC
 nudC nuclear distribution protein
 184
 0.91
chr2_69002223_69002932 0.21 ARHGAP25
 Rho GTPase activating protein 25
 505
 0.84
chr19_40596081_40597156 0.21 AC005614.3
43
 0.64
chr9_99539749_99540719 0.21 ZNF510
 zinc finger protein 510
 94
 0.98
chr18_9673690_9673841 0.21 RAB31
 RAB31, member RAS oncogene family
 34397
 0.15
chr16_31276973_31277152 0.21 ENSG00000252876
 .
 1750
 0.22
chr8_27183780_27184189 0.21 PTK2B
 protein tyrosine kinase 2 beta
 356
 0.89
chr1_234861269_234861851 0.21 ENSG00000201638
 .
 112160
 0.06
chr7_26332124_26332363 0.21 SNX10
 sorting nexin 10
 431
 0.87
chr7_140396423_140396944 0.21 NDUFB2
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
 105
 0.63
chr1_161592822_161592973 0.20 FCGR3B
 Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
 7925
 0.12
chr14_89258910_89259265 0.20 EML5
 echinoderm microtubule associated protein like 5
 9
 0.98
chr3_71956368_71956519 0.20 ENSG00000239250
 .
 80115
 0.1
chr3_123304144_123304696 0.20 MYLK-AS1
 MYLK antisense RNA 1
 17
 0.87
chr13_28542515_28542921 0.20 CDX2
 caudal type homeobox 2
 2558
 0.21
chr3_32858150_32858717 0.20 TRIM71
 tripartite motif containing 71, E3 ubiquitin protein ligase
 1077
 0.61
chr1_149764655_149765085 0.20 RP11-196G18.3
294
 0.77
chr9_86755575_86756256 0.20 RP11-380F14.2
137219
 0.04
chr11_133797734_133798200 0.20 IGSF9B
 immunoglobulin superfamily, member 9B
 18220
 0.18
chr17_36859934_36860212 0.20 ENSG00000265930
 .
 1489
 0.16
chr11_66106791_66106942 0.20 RIN1
 Ras and Rab interactor 1
 2555
 0.09
chr19_37957537_37958312 0.20 ZNF569
 zinc finger protein 569
 186
 0.85
chr10_74113543_74114362 0.20 DNAJB12
 DnaJ (Hsp40) homolog, subfamily B, member 12
 186
 0.95
chr1_150540056_150540997 0.20 ENSG00000264508
 .
 1190
 0.22
chr3_51976372_51976799 0.20 PARP3
 poly (ADP-ribose) polymerase family, member 3
 210
 0.75
chr17_35216667_35216818 0.20 RP11-445F12.1
77179
 0.07

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF143

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.2 0.6 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 0.4 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.1 0.7 GO:0001553 luteinization(GO:0001553)
0.1 0.3 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.1 0.4 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.1 0.3 GO:0030091 protein repair(GO:0030091)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.3 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.2 GO:0072224 metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.1 0.6 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.4 GO:0031053 primary miRNA processing(GO:0031053)
0.1 0.2 GO:1903224 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.2 GO:0071883 adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.2 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.1 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.2 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.2 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.2 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.0 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.3 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.3 GO:0034644 cellular response to UV(GO:0034644)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0007097 nuclear migration(GO:0007097)
0.0 0.2 GO:0060479 lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.3 GO:0045843 negative regulation of striated muscle tissue development(GO:0045843)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.0 GO:0060157 urinary bladder development(GO:0060157)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:0072217 negative regulation of metanephros development(GO:0072217)
0.0 0.0 GO:0003136 negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0 0.1 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0031659 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.2 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.2 GO:0002467 germinal center formation(GO:0002467)
0.0 0.2 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.0 GO:0030812 negative regulation of nucleotide catabolic process(GO:0030812)
0.0 0.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.2 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.0 GO:0045357 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.2 GO:0032925 regulation of activin receptor signaling pathway(GO:0032925)
0.0 0.0 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.1 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.2 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.1 GO:0031274 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.0 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.1 GO:0016553 base conversion or substitution editing(GO:0016553)
0.0 0.1 GO:0072498 embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.2 GO:0032647 interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.4 GO:0051899 membrane depolarization(GO:0051899)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0071803 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.0 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.0 GO:0019322 pentose biosynthetic process(GO:0019322)
0.0 0.1 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.2 GO:0042088 T-helper 1 type immune response(GO:0042088)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.2 GO:0007398 ectoderm development(GO:0007398)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.0 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.1 GO:0052805 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.1 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.0 0.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.0 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.0 GO:0043474 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.0 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.4 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.1 GO:0060346 bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0 0.1 GO:0060263 regulation of respiratory burst(GO:0060263)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.0 GO:0046931 pore complex assembly(GO:0046931)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.1 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 0.0 GO:0051532 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.1 GO:0060539 diaphragm development(GO:0060539)
0.0 0.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.0 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0 0.1 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.2 GO:0019674 NAD metabolic process(GO:0019674)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.0 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.0 0.3 GO:0006413 translational initiation(GO:0006413)
0.0 0.6 GO:0051607 defense response to virus(GO:0051607)
0.0 0.0 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0031648 protein destabilization(GO:0031648)
0.0 0.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.3 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.0 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:0060897 neural plate anterior/posterior regionalization(GO:0021999) neural plate pattern specification(GO:0060896) neural plate regionalization(GO:0060897)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0070820 tertiary granule(GO:0070820)
0.2 0.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.7 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.2 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1 0.3 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.4 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 0.7 GO:0001772 immunological synapse(GO:0001772)
0.1 0.3 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0031083 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.1 GO:0016600 flotillin complex(GO:0016600)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.0 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.0 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.8 GO:0001726 ruffle(GO:0001726)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.5 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.0 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.1 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0042641 actomyosin(GO:0042641)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0035197 siRNA binding(GO:0035197)
0.1 0.3 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.1 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.2 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.5 GO:0035173 histone kinase activity(GO:0035173)
0.1 0.2 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.1 0.1 GO:0016803 ether hydrolase activity(GO:0016803)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.1 0.2 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.3 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.6 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.2 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0034648 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0032405 MutLalpha complex binding(GO:0032405)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.0 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0090079 translation activator activity(GO:0008494) translation regulator activity, nucleic acid binding(GO:0090079)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.0 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.0 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.1 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.4 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.3 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.8 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.2 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.0 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.2 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway