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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF143

Z-value: 1.50

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Transcription factors associated with ZNF143

Gene Symbol	Gene ID	Gene Info
ZNF143 Ensembl NCBI GeneCards UniProt	ENSG00000166478.5	ZNF143

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF143	chr11_9548903_9549060	14937	0.157316	-0.63	6.6e-02	Click!
ZNF143	chr11_9510814_9510966	23154	0.139994	-0.55	1.3e-01	Click!
ZNF143	chr11_9511154_9511374	22780	0.140892	-0.48	2.0e-01	Click!
ZNF143	chr11_9482658_9482912	181	0.862863	0.43	2.5e-01	Click!
ZNF143	chr11_9555045_9555196	21076	0.142993	0.39	3.0e-01	Click!

Activity of the ZNF143 motif across conditions

Conditions sorted by the z-value of the ZNF143 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_135089555_135089795	1.46	ADAM8	ADAM metallopeptidase domain 8	679	0.52
chr19_48833249_48833485	0.76	EMP3	epithelial membrane protein 3	4502	0.13
chr2_42599068_42599219	0.75	COX7A2L	cytochrome c oxidase subunit VIIa polypeptide 2 like	2993	0.32
chr18_21464195_21464346	0.74	LAMA3	laminin, alpha 3	467	0.84
chr7_150755256_150755900	0.73	CDK5	cyclin-dependent kinase 5	39	0.77
chr17_43302789_43303077	0.63	CTD-2020K17.1		3344	0.12
chrX_152200996_152201209	0.59	PNMA3	paraneoplastic Ma antigen 3	23664	0.12
chr22_20067197_20067578	0.56	DGCR8	DGCR8 microprocessor complex subunit	368	0.7
chr10_74095282_74095433	0.56	DNAJB12	DnaJ (Hsp40) homolog, subfamily B, member 12	9362	0.19
chr19_17515989_17516450	0.54	BST2	bone marrow stromal cell antigen 2	238	0.54
chr2_2617005_2617869	0.52	MYT1L	myelin transcription factor 1-like	282471	0.01
chr2_74756873_74757049	0.52	AUP1	ancient ubiquitous protein 1	105	0.55
chr17_56410837_56411117	0.52	MIR142	microRNA 142	1108	0.32
chr19_10381757_10382103	0.51	ICAM1	intercellular adhesion molecule 1	134	0.89
chr19_1407342_1407493	0.50	DAZAP1	DAZ associated protein 1	151	0.88
chr11_2550000_2550151	0.49	KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	66958	0.09
chr8_145734147_145734421	0.48	MFSD3	major facilitator superfamily domain containing 3	173	0.83
chr12_53894777_53895686	0.47	TARBP2	TAR (HIV-1) RNA binding protein 2	150	0.79
chr9_95826666_95826817	0.47	SUSD3	sushi domain containing 3	4641	0.2
chr1_6479504_6479655	0.45	HES2	hes family bHLH transcription factor 2	384	0.76
chr2_242556723_242557374	0.45	THAP4	THAP domain containing 4	132	0.94
chr11_809579_809818	0.45	RPLP2	ribosomal protein, large, P2	51	0.91
chr17_76250693_76250844	0.44	TMEM235	transmembrane protein 235	22646	0.12
chr2_74669340_74669491	0.44	RTKN	rhotekin	389	0.66
chr10_124134109_124134260	0.44	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	28	0.98
chr2_26100038_26101197	0.44	ASXL2	additional sex combs like 2 (Drosophila)	718	0.76
chr1_939046_939197	0.44	HES4	hes family bHLH transcription factor 4	3569	0.11
chr7_6199542_6199693	0.43	CYTH3	cytohesin 3	13089	0.14
chr21_45579276_45579734	0.43	AP001055.1		14075	0.13
chr19_2562679_2562830	0.42	CTC-265F19.2		49106	0.09
chrX_49042899_49043187	0.41	PRICKLE3	prickle homolog 3 (Drosophila)	198	0.86
chr7_45076135_45076286	0.41	CCM2	cerebral cavernous malformation 2	8939	0.15
chr14_36295319_36295470	0.41	BRMS1L	breast cancer metastasis-suppressor 1-like	130	0.86
chr10_73532392_73533248	0.40	C10orf54	chromosome 10 open reading frame 54	435	0.83
chr2_178417541_178417760	0.40	TTC30B	tetratricopeptide repeat domain 30B	92	0.97
chr6_31802179_31802624	0.39	C6orf48	chromosome 6 open reading frame 48	3	0.87
chr19_36398415_36398818	0.39	TYROBP	TYRO protein tyrosine kinase binding protein	533	0.58
chr2_106362063_106362974	0.39	NCK2	NCK adaptor protein 2	330	0.94
chr3_69591746_69591897	0.38	FRMD4B	FERM domain containing 4B	87	0.99
chr8_141517648_141517821	0.38	CTA-204B4.2		408	0.85
chr19_55629138_55629447	0.38	PPP1R12C	protein phosphatase 1, regulatory subunit 12C	365	0.75
chr16_84582878_84583147	0.38	TLDC1	TBC/LysM-associated domain containing 1	4627	0.21
chr13_41768167_41768864	0.38	KBTBD7	kelch repeat and BTB (POZ) domain containing 7	187	0.94
chr5_1004071_1004222	0.38	ENSG00000221244	.	156	0.93
chr10_46168316_46168717	0.37	ZFAND4	zinc finger, AN1-type domain 4	288	0.92
chr12_110906550_110906725	0.37	GPN3	GPN-loop GTPase 3	111	0.83
chr17_80260833_80260984	0.37	CD7	CD7 molecule	14520	0.1
chr8_142413039_142413204	0.37	CTD-3064M3.4		10447	0.12
chr1_26868114_26868336	0.36	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	1378	0.34
chr3_57038475_57038626	0.36	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	27147	0.18
chrX_147462854_147463013	0.36	AC002368.4		119202	0.06
chr19_4791521_4791672	0.36	FEM1A	fem-1 homolog a (C. elegans)	132	0.93
chr3_48230084_48230363	0.36	CDC25A	cell division cycle 25A	331	0.83
chr1_200008337_200008553	0.35	NR5A2	nuclear receptor subfamily 5, group A, member 2	3272	0.23
chr1_27989345_27989660	0.35	RP11-288L9.4		6477	0.12
chr19_13274647_13274798	0.35	CTC-250I14.6		9715	0.11
chr14_81938636_81938919	0.35	STON2	stonin 2	35968	0.21
chr14_91096638_91096789	0.35	RP11-1078H9.5		12269	0.18
chr19_2093663_2094074	0.35	MOB3A	MOB kinase activator 3A	2401	0.16
chr1_154986335_154986486	0.35	ZBTB7B	zinc finger and BTB domain containing 7B	514	0.55
chr8_144634608_144634759	0.35	GSDMD	gasdermin D	694	0.41
chr15_41913046_41914152	0.34	MGA	MGA, MAX dimerization protein	135	0.96
chr22_45706838_45707043	0.34	FAM118A	family with sequence similarity 118, member A	935	0.58
chr1_28974832_28975188	0.34	ENSG00000270103	.	102	0.95
chr3_182879726_182880740	0.34	LAMP3	lysosomal-associated membrane protein 3	430	0.86
chr7_140098327_140098552	0.33	SLC37A3	solute carrier family 37, member 3	90	0.96
chr20_5100236_5100597	0.33	PCNA	proliferating cell nuclear antigen	256	0.85
chr1_2165353_2165549	0.33	SKI	v-ski avian sarcoma viral oncogene homolog	5317	0.14
chr19_48673594_48673912	0.32	LIG1	ligase I, DNA, ATP-dependent	107	0.61
chr19_5255691_5255842	0.32	PTPRS	protein tyrosine phosphatase, receptor type, S	30408	0.19
chr16_279456_279667	0.32	LUC7L	LUC7-like (S. cerevisiae)	99	0.93
chr17_81047529_81047808	0.31	METRNL	meteorin, glial cell differentiation regulator-like	4326	0.27
chr3_5028227_5029021	0.31	BHLHE40-AS1	BHLHE40 antisense RNA 1	6978	0.21
chr8_21754477_21754628	0.31	DOK2	docking protein 2, 56kDa	16622	0.18
chr17_28927099_28927365	0.31	SMURF2P1	SMAD specific E3 ubiquitin protein ligase 2 pseudogene 1	651	0.67
chr22_39637649_39637800	0.31	PDGFB	platelet-derived growth factor beta polypeptide	589	0.68
chr11_64005411_64005562	0.31	VEGFB	vascular endothelial growth factor B	478	0.51
chr14_39901349_39901640	0.31	FBXO33	F-box protein 33	176	0.97
chr16_70487949_70488475	0.31	FUK	fucokinase	112	0.94
chr19_44331131_44331711	0.31	ZNF283	zinc finger protein 283	23	0.53
chr19_3801497_3801822	0.31	MATK	megakaryocyte-associated tyrosine kinase	138	0.93
chr5_175958496_175958647	0.30	RNF44	ring finger protein 44	925	0.45
chr20_1446772_1447463	0.29	NSFL1C	NSFL1 (p97) cofactor (p47)	356	0.84
chr6_150070946_150071995	0.29	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	290	0.87
chr19_49004084_49004235	0.29	LMTK3	lemur tyrosine kinase 3	10902	0.1
chr7_112090576_112091250	0.29	IFRD1	interferon-related developmental regulator 1	162	0.96
chr6_42332930_42333081	0.29	ENSG00000221252	.	47129	0.14
chr9_131012193_131012363	0.29	ENSG00000264823	.	4969	0.09
chr11_93394564_93394780	0.28	KIAA1731	KIAA1731	133	0.94
chr19_17517338_17517489	0.28	MVB12A	multivesicular body subunit 12A	459	0.54
chr12_6570769_6570920	0.28	VAMP1	vesicle-associated membrane protein 1 (synaptobrevin 1)	8967	0.09
chr19_17634183_17634515	0.28	FAM129C	family with sequence similarity 129, member C	239	0.85
chr22_37542366_37542517	0.28	IL2RB	interleukin 2 receptor, beta	3589	0.14
chr8_27631821_27631972	0.28	ESCO2	establishment of sister chromatid cohesion N-acetyltransferase 2	7	0.92
chrX_48814848_48815217	0.28	OTUD5	OTU domain containing 5	139	0.9
chr4_6675763_6675979	0.28	AC093323.1	Uncharacterized protein	18318	0.14
chr9_130497113_130497635	0.28	TOR2A	torsin family 2, member A	197	0.88
chr19_36618863_36619073	0.28	CAPNS1	calpain, small subunit 1	11509	0.09
chr12_96429136_96429440	0.28	LTA4H	leukotriene A4 hydrolase	151	0.95
chr17_62658617_62658986	0.28	SMURF2	SMAD specific E3 ubiquitin protein ligase 2	615	0.77
chr1_53164097_53164296	0.28	COA7	cytochrome c oxidase assembly factor 7	158	0.94
chr8_41907411_41908748	0.27	KAT6A	K(lysine) acetyltransferase 6A	1426	0.43
chr15_75315646_75315949	0.27	PPCDC	phosphopantothenoylcysteine decarboxylase	99	0.96
chr16_89042188_89042390	0.27	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	1112	0.45
chr7_63386955_63387300	0.27	ENSG00000265017	.	87	0.98
chr10_1696776_1696927	0.27	ADARB2	adenosine deaminase, RNA-specific, B2 (non-functional)	82819	0.11
chr7_72936423_72936636	0.27	BAZ1B	bromodomain adjacent to zinc finger domain, 1B	73	0.96
chr15_86337104_86338160	0.27	KLHL25	kelch-like family member 25	468	0.73
chr1_181451777_181451943	0.27	CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	856	0.76
chrX_118823023_118823250	0.27	SEPT6	septin 6	3656	0.22
chr7_72439858_72440009	0.27	TRIM74	tripartite motif containing 74	64	0.95
chr16_88366626_88367008	0.26	ZNF469	zinc finger protein 469	127062	0.05
chr10_79613508_79613659	0.26	AL391421.1	Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964	13050	0.18
chr9_38621823_38622122	0.26	FAM201A	family with sequence similarity 201, member A	887	0.5
chr1_117594372_117594685	0.26	RP11-27K13.3		7584	0.17
chr17_8076861_8077643	0.26	ENSG00000200463	.	347	0.7
chr17_26874549_26874726	0.26	UNC119	unc-119 homolog (C. elegans)	1780	0.17
chr1_16470291_16470442	0.26	RP11-276H7.2		11340	0.12
chr2_240187102_240187645	0.26	ENSG00000265215	.	39784	0.13
chr7_26191457_26191700	0.26	NFE2L3	nuclear factor, erythroid 2-like 3	282	0.91
chr15_94406450_94406737	0.26	ENSG00000222409	.	33663	0.25
chr19_39811900_39812051	0.25	CTC-246B18.8		477	0.64
chr18_23670660_23670942	0.25	SS18	synovial sarcoma translocation, chromosome 18	64	0.98
chr19_45393848_45394047	0.25	TOMM40	translocase of outer mitochondrial membrane 40 homolog (yeast)	121	0.58
chr14_103801113_103802028	0.25	EIF5	eukaryotic translation initiation factor 5	284	0.87
chr2_96782390_96782846	0.25	ADRA2B	adrenoceptor alpha 2B	634	0.68
chr5_176944022_176944323	0.25	DDX41	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	255	0.85
chr1_32645201_32645477	0.25	TXLNA	taxilin alpha	52	0.94
chr7_134670907_134671205	0.25	AGBL3	ATP/GTP binding protein-like 3	203	0.96
chr17_9330961_9331112	0.25	AC087501.1		24478	0.18
chr14_75926184_75926335	0.25	JDP2	Jun dimerization protein 2	27422	0.16
chr12_56498056_56498239	0.25	PA2G4	proliferation-associated 2G4, 38kDa	44	0.92
chr19_49972030_49972206	0.25	FLT3LG	fms-related tyrosine kinase 3 ligand	5367	0.06
chr11_112097343_112097611	0.24	PTS	6-pyruvoyltetrahydropterin synthase	322	0.82
chr22_37937663_37937814	0.24	RP5-1177I5.3		8295	0.12
chr11_119562641_119562792	0.24	ENSG00000199217	.	35695	0.14
chrX_132091720_132091956	0.24	HS6ST2	heparan sulfate 6-O-sulfotransferase 2	494	0.87
chr1_151226917_151227146	0.24	PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	148	0.91
chr22_42696607_42696758	0.24	TCF20	transcription factor 20 (AR1)	42940	0.14
chr1_28195302_28195741	0.24	THEMIS2	thymocyte selection associated family member 2	3534	0.14
chr14_91868738_91869034	0.23	CCDC88C	coiled-coil domain containing 88C	14804	0.23
chr1_207243797_207243948	0.23	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	5523	0.14
chr3_9773477_9774131	0.23	BRPF1	bromodomain and PHD finger containing, 1	332	0.81
chr12_89747023_89747227	0.23	DUSP6	dual specificity phosphatase 6	77	0.98
chr9_95794200_95794351	0.23	FGD3	FYVE, RhoGEF and PH domain containing 3	16933	0.17
chr3_158288936_158289364	0.23	MLF1	myeloid leukemia factor 1	100	0.76
chr19_13952735_13952973	0.23	ENSG00000207980	.	5381	0.08
chr1_1689799_1689950	0.23	NADK	NAD kinase	140	0.94
chr21_17959283_17959568	0.23	ENSG00000207863	.	3132	0.31
chr4_40058976_40059529	0.23	N4BP2	NEDD4 binding protein 2	696	0.68
chr9_139581476_139581762	0.23	AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2	229	0.84
chr18_3447400_3448025	0.23	TGIF1	TGFB-induced factor homeobox 1	105	0.97
chr15_72522652_72522803	0.23	PKM	pyruvate kinase, muscle	664	0.65
chr22_37618634_37618785	0.23	SSTR3	somatostatin receptor 3	10347	0.13
chr3_150126096_150126425	0.23	TSC22D2	TSC22 domain family, member 2	138	0.98
chr19_1260409_1260809	0.22	CIRBP	cold inducible RNA binding protein	546	0.56
chr5_142177952_142178103	0.22	ARHGAP26	Rho GTPase activating protein 26	25745	0.22
chr6_36164778_36164969	0.22	RP1-179N16.6		107	0.53
chr19_45257252_45257704	0.22	BCL3	B-cell CLL/lymphoma 3	2900	0.15
chr15_90447970_90448121	0.22	C15orf38	chromosome 15 open reading frame 38	870	0.42
chr7_65579625_65579846	0.22	CRCP	CGRP receptor component	78	0.97
chr4_6687752_6687903	0.22	AC093323.1	Uncharacterized protein	6362	0.15
chrX_65234090_65234241	0.22	ENSG00000207939	.	4547	0.23
chr11_73358513_73358664	0.22	PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1	6	0.98
chr11_18720549_18721118	0.22	TMEM86A	transmembrane protein 86A	495	0.74
chr2_223169880_223170456	0.22	CCDC140	coiled-coil domain containing 140	2471	0.27
chr4_1581349_1582263	0.22	FAM53A	family with sequence similarity 53, member A	75329	0.08
chr16_21170219_21170819	0.22	DNAH3	dynein, axonemal, heavy chain 3	243	0.71
chr6_159464305_159464462	0.22	TAGAP	T-cell activation RhoGTPase activating protein	1667	0.38
chr7_75024883_75025034	0.22	TRIM73	tripartite motif containing 73	55	0.84
chr1_6532288_6532439	0.22	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	6108	0.12
chr17_40440128_40440459	0.22	STAT5A	signal transducer and activator of transcription 5A	194	0.91
chr5_131831286_131831908	0.21	IRF1	interferon regulatory factor 1	5107	0.15
chr1_231917497_231917650	0.21	ENSG00000222986	.	111192	0.06
chr1_27248269_27248533	0.21	NUDC	nudC nuclear distribution protein	184	0.91
chr2_69002223_69002932	0.21	ARHGAP25	Rho GTPase activating protein 25	505	0.84
chr19_40596081_40597156	0.21	AC005614.3		43	0.64
chr9_99539749_99540719	0.21	ZNF510	zinc finger protein 510	94	0.98
chr18_9673690_9673841	0.21	RAB31	RAB31, member RAS oncogene family	34397	0.15
chr16_31276973_31277152	0.21	ENSG00000252876	.	1750	0.22
chr8_27183780_27184189	0.21	PTK2B	protein tyrosine kinase 2 beta	356	0.89
chr1_234861269_234861851	0.21	ENSG00000201638	.	112160	0.06
chr7_26332124_26332363	0.21	SNX10	sorting nexin 10	431	0.87
chr7_140396423_140396944	0.21	NDUFB2	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa	105	0.63
chr1_161592822_161592973	0.20	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	7925	0.12
chr14_89258910_89259265	0.20	EML5	echinoderm microtubule associated protein like 5	9	0.98
chr3_71956368_71956519	0.20	ENSG00000239250	.	80115	0.1
chr3_123304144_123304696	0.20	MYLK-AS1	MYLK antisense RNA 1	17	0.87
chr13_28542515_28542921	0.20	CDX2	caudal type homeobox 2	2558	0.21
chr3_32858150_32858717	0.20	TRIM71	tripartite motif containing 71, E3 ubiquitin protein ligase	1077	0.61
chr1_149764655_149765085	0.20	RP11-196G18.3		294	0.77
chr9_86755575_86756256	0.20	RP11-380F14.2		137219	0.04
chr11_133797734_133798200	0.20	IGSF9B	immunoglobulin superfamily, member 9B	18220	0.18
chr17_36859934_36860212	0.20	ENSG00000265930	.	1489	0.16
chr11_66106791_66106942	0.20	RIN1	Ras and Rab interactor 1	2555	0.09
chr19_37957537_37958312	0.20	ZNF569	zinc finger protein 569	186	0.85
chr10_74113543_74114362	0.20	DNAJB12	DnaJ (Hsp40) homolog, subfamily B, member 12	186	0.95
chr1_150540056_150540997	0.20	ENSG00000264508	.	1190	0.22
chr3_51976372_51976799	0.20	PARP3	poly (ADP-ribose) polymerase family, member 3	210	0.75
chr17_35216667_35216818	0.20	RP11-445F12.1		77179	0.07

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF143

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.2	0.6	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.1	0.4	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.1	0.7	GO:0001553	luteinization(GO:0001553)
0.1	0.3	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.1	0.4	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.1	0.3	GO:0030091	protein repair(GO:0030091)
0.1	0.3	GO:0034421	post-translational protein acetylation(GO:0034421)
0.1	0.3	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.1	0.2	GO:0072224	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.1	0.6	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.4	GO:0031053	primary miRNA processing(GO:0031053)
0.1	0.2	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.2	GO:0071883	adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1	0.6	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	0.2	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.1	0.3	GO:0048625	myoblast fate commitment(GO:0048625)
0.1	0.2	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1	0.2	GO:0031167	rRNA methylation(GO:0031167)
0.1	0.2	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.2	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.2	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.3	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.2	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.3	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.3	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.2	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.2	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.3	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.3	GO:0034644	cellular response to UV(GO:0034644)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.2	GO:0060479	lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.3	GO:0045843	negative regulation of striated muscle tissue development(GO:0045843)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.1	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.0	GO:0003136	negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.1	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.2	GO:0033146	regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.2	GO:0002467	germinal center formation(GO:0002467)
0.0	0.2	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.2	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.0	GO:0045357	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.2	GO:0032925	regulation of activin receptor signaling pathway(GO:0032925)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0072498	embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.2	GO:0032647	interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.4	GO:0051899	membrane depolarization(GO:0051899)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0019322	pentose biosynthetic process(GO:0019322)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.2	GO:0042088	T-helper 1 type immune response(GO:0042088)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.2	GO:0007398	ectoderm development(GO:0007398)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.0	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.1	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.0	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.0	GO:0043474	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0	0.0	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.4	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.2	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.1	GO:0060346	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0	0.1	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.1	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.0	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0045047	protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0	0.3	GO:0030433	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0	0.2	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
0.0	0.2	GO:0019674	NAD metabolic process(GO:0019674)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.6	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.3	GO:0006446	regulation of translational initiation(GO:0006446)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.3	GO:0006413	translational initiation(GO:0006413)
0.0	0.6	GO:0051607	defense response to virus(GO:0051607)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.2	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.3	GO:0043966	histone H3 acetylation(GO:0043966)
0.0	0.0	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:0060897	neural plate anterior/posterior regionalization(GO:0021999) neural plate pattern specification(GO:0060896) neural plate regionalization(GO:0060897)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0071300	cellular response to retinoic acid(GO:0071300)
0.0	0.0	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:0070820	tertiary granule(GO:0070820)
0.2	0.6	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	0.7	GO:0005606	laminin-1 complex(GO:0005606)
0.1	0.2	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.3	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	0.4	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1	0.7	GO:0001772	immunological synapse(GO:0001772)
0.1	0.3	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.3	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.2	GO:0031083	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.3	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.2	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.2	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)
0.0	0.5	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.3	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.3	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.0	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.8	GO:0001726	ruffle(GO:0001726)
0.0	0.1	GO:0030914	STAGA complex(GO:0030914)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.3	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.5	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.1	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.3	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.0	GO:0060203	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.1	GO:0042641	actomyosin(GO:0042641)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.4	GO:0035197	siRNA binding(GO:0035197)
0.1	0.3	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.1	0.3	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1	0.2	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1	0.3	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.1	0.5	GO:0035173	histone kinase activity(GO:0035173)
0.1	0.2	GO:0004948	calcitonin receptor activity(GO:0004948)
0.1	0.2	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.1	0.1	GO:0016803	ether hydrolase activity(GO:0016803)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.2	GO:0019215	intermediate filament binding(GO:0019215)
0.1	0.2	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1	0.1	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.3	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.5	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.6	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.6	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.2	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.7	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.2	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.2	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.7	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0032405	MutLalpha complex binding(GO:0032405)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.2	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.3	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.2	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0090079	translation activator activity(GO:0008494) translation regulator activity, nucleic acid binding(GO:0090079)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.6	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.2	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.0	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.3	GO:0016675	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.2	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.2	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.2	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.3	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.8	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.8	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.1	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.6	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.3	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.4	PID BARD1 PATHWAY	BARD1 signaling events
0.0	0.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.4	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.3	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.9	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.5	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.5	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.3	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.4	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.3	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.5	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.8	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.2	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.7	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	REACTOME CD28 CO STIMULATION	Genes involved in CD28 co-stimulation
0.2	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.3	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway