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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF282

Z-value: 1.42

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Transcription factors associated with ZNF282

Gene Symbol	Gene ID	Gene Info
ZNF282 Ensembl NCBI GeneCards UniProt	ENSG00000170265.7	ZNF282

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF282	chr7_148888070_148888331	4377	0.181938	0.68	4.5e-02	Click!
ZNF282	chr7_148878257_148878408	14245	0.143314	-0.67	4.6e-02	Click!
ZNF282	chr7_148893161_148893454	665	0.660005	0.63	6.9e-02	Click!
ZNF282	chr7_148893506_148893991	1106	0.456158	0.41	2.8e-01	Click!
ZNF282	chr7_148888671_148888822	3831	0.190840	0.40	2.8e-01	Click!

Activity of the ZNF282 motif across conditions

Conditions sorted by the z-value of the ZNF282 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_46572021_46572172	0.77	SLC38A1	solute carrier family 38, member 1	89388	0.1
chr17_39969662_39969906	0.65	FKBP10	FK506 binding protein 10, 65 kDa	601	0.45
chr11_119954135_119954286	0.55	TRIM29	tripartite motif containing 29	37398	0.19
chr7_100771927_100772106	0.49	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	1637	0.23
chr16_58534463_58534728	0.48	NDRG4	NDRG family member 4	545	0.68
chr11_119953003_119953290	0.48	TRIM29	tripartite motif containing 29	38462	0.18
chr7_1959519_1959814	0.45	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	20519	0.22
chr5_125936367_125936518	0.44	PHAX	phosphorylated adaptor for RNA export	482	0.79
chr1_88798905_88799056	0.42	ENSG00000239504	.	144817	0.05
chr5_67512014_67512283	0.42	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	544	0.82
chr15_94544847_94544998	0.42	ENSG00000212022	.	79498	0.11
chr2_74780571_74780754	0.42	LOXL3	lysyl oxidase-like 3	400	0.5
chr8_96307989_96308140	0.42	C8orf37	chromosome 8 open reading frame 37	26635	0.24
chr11_18719924_18720222	0.41	TMEM86A	transmembrane protein 86A	265	0.89
chr5_137688953_137689239	0.41	KDM3B	lysine (K)-specific demethylase 3B	811	0.51
chr1_150971821_150972085	0.41	FAM63A	family with sequence similarity 63, member A	1307	0.24
chr1_163038601_163039117	0.41	RGS4	regulator of G-protein signaling 4	76	0.98
chr3_25471806_25472309	0.41	RARB	retinoic acid receptor, beta	2255	0.41
chr6_10748064_10748484	0.41	TMEM14B	transmembrane protein 14B	210	0.53
chr21_38711081_38711320	0.40	AP001437.1		27034	0.16
chr8_55294341_55294557	0.39	ENSG00000244107	.	38579	0.17
chrX_100074585_100074736	0.39	CSTF2	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	724	0.63
chr20_50045192_50045343	0.39	ENSG00000266761	.	24247	0.22
chr1_226069091_226069419	0.38	TMEM63A	transmembrane protein 63A	814	0.51
chr10_11865085_11865286	0.38	PROSER2	proline and serine-rich protein 2	212	0.95
chr12_77719208_77719557	0.38	ENSG00000238769	.	162577	0.04
chr2_161491867_161492018	0.38	RBMS1	RNA binding motif, single stranded interacting protein 1	141637	0.05
chrX_46432817_46433047	0.38	CHST7	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	287	0.92
chr2_157189525_157189762	0.37	NR4A2	nuclear receptor subfamily 4, group A, member 2	411	0.9
chr2_145276293_145276624	0.37	ZEB2-AS1	ZEB2 antisense RNA 1	434	0.52
chr10_114820084_114820658	0.37	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	83308	0.1
chr11_119954548_119954699	0.37	TRIM29	tripartite motif containing 29	36985	0.19
chr20_57586431_57586603	0.37	CTSZ	cathepsin Z	4215	0.17
chr3_16006218_16006514	0.37	ENSG00000207815	.	91088	0.08
chr20_43150833_43151092	0.36	SERINC3	serine incorporator 3	212	0.91
chr4_2486639_2486842	0.36	RNF4	ring finger protein 4	4798	0.2
chr7_149572287_149572438	0.36	ATP6V0E2	ATPase, H+ transporting V0 subunit e2	1230	0.35
chr1_197887720_197887871	0.36	LHX9	LIM homeobox 9	1266	0.53
chr17_7121037_7121301	0.36	DLG4	discs, large homolog 4 (Drosophila)	503	0.43
chr12_125412025_125412330	0.36	UBC	ubiquitin C	10263	0.16
chr12_127256953_127257104	0.35	ENSG00000239776	.	393644	0.01
chr9_96930088_96930349	0.35	ENSG00000199165	.	8016	0.16
chr6_165722376_165722527	0.35	C6orf118	chromosome 6 open reading frame 118	109	0.98
chr15_75471507_75471789	0.35	C15orf39	chromosome 15 open reading frame 39	16336	0.13
chr1_161369629_161370065	0.35	ENSG00000206921	.	1232	0.42
chr19_13977402_13977553	0.34	ENSG00000207613	.	8036	0.08
chr2_225846726_225846877	0.34	ENSG00000263828	.	28456	0.22
chr14_63672700_63672938	0.34	RHOJ	ras homolog family member J	1242	0.54
chr20_21961725_21961876	0.34	PAX1	paired box 1	274939	0.02
chrX_65220606_65220757	0.34	RP6-159A1.3		1088	0.56
chr21_42739358_42739509	0.33	MX2	myxovirus (influenza virus) resistance 2 (mouse)	2579	0.29
chr1_243646920_243647071	0.33	RP11-269F20.1		61839	0.14
chr6_34358484_34358635	0.33	NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	1892	0.33
chr5_58335725_58336097	0.33	RP11-266N13.2		323	0.69
chr8_13372824_13372975	0.33	DLC1	deleted in liver cancer 1	503	0.82
chr12_65672666_65673070	0.33	MSRB3	methionine sulfoxide reductase B3	101	0.97
chr7_93943609_93943760	0.33	COL1A2	collagen, type I, alpha 2	80189	0.11
chr7_156687876_156688027	0.33	LMBR1	limb development membrane protein 1	2027	0.34
chr9_116356768_116357019	0.33	RGS3	regulator of G-protein signaling 3	1127	0.54
chrX_100183665_100184190	0.33	XKRX	XK, Kell blood group complex subunit-related, X-linked	29	0.98
chr17_61722686_61722837	0.32	MAP3K3	mitogen-activated protein kinase kinase kinase 3	22691	0.13
chrX_133687659_133687810	0.32	ENSG00000223749	.	6993	0.12
chr20_8651278_8651429	0.32	ENSG00000222298	.	60466	0.12
chr5_25569497_25569648	0.31	ENSG00000201016	.	131861	0.06
chr2_242319557_242319708	0.31	FARP2	FERM, RhoGEF and pleckstrin domain protein 2	7368	0.16
chr1_87223134_87223385	0.31	SH3GLB1	SH3-domain GRB2-like endophilin B1	52681	0.12
chr1_226852545_226852696	0.31	ITPKB-AS1	ITPKB antisense RNA 1	3978	0.24
chr12_2420181_2420332	0.31	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	41314	0.18
chr17_37844389_37844572	0.31	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	87	0.53
chr16_1979223_1979447	0.31	HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	10894	0.06
chr11_82774150_82774358	0.31	RAB30	RAB30, member RAS oncogene family	8616	0.18
chrY_6883288_6883439	0.31	TBL1Y	transducin (beta)-like 1, Y-linked	104636	0.08
chr10_114206747_114206976	0.31	VTI1A	vesicle transport through interaction with t-SNAREs 1A	155	0.54
chr15_41850580_41851004	0.31	TYRO3	TYRO3 protein tyrosine kinase	440	0.79
chr12_113841803_113841954	0.31	SDS	serine dehydratase	185	0.94
chrX_46616562_46616983	0.30	SLC9A7	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	1718	0.46
chr19_13319063_13319297	0.30	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	49034	0.08
chr8_97170599_97170750	0.30	GDF6	growth differentiation factor 6	2346	0.36
chr1_221342999_221343150	0.30	HLX	H2.0-like homeobox	288490	0.01
chr10_89265401_89265555	0.30	MINPP1	multiple inositol-polyphosphate phosphatase 1	846	0.69
chrY_19466305_19466456	0.30	ENSG00000252315	.	203364	0.03
chr1_183605727_183605878	0.30	RGL1	ral guanine nucleotide dissociation stimulator-like 1	558	0.58
chr8_23571667_23572036	0.29	RP11-175E9.1		7197	0.17
chr11_66444702_66445046	0.29	RBM4B	RNA binding motif protein 4B	345	0.79
chr20_2451568_2451719	0.29	SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	144	0.94
chr15_62353285_62353511	0.29	RP11-643M14.1		685	0.44
chr15_40234807_40235047	0.29	ENSG00000238564	.	7980	0.15
chr11_119954900_119955051	0.28	TRIM29	tripartite motif containing 29	36633	0.19
chr19_6110825_6111002	0.28	RFX2	regulatory factor X, 2 (influences HLA class II expression)	301	0.84
chr8_37344900_37345051	0.28	RP11-150O12.6		29564	0.23
chr17_46627635_46627871	0.28	HOXB-AS3	HOXB cluster antisense RNA 3	761	0.38
chr1_86043929_86044119	0.28	DDAH1	dimethylarginine dimethylaminohydrolase 1	91	0.97
chr3_123477356_123477507	0.28	MYLK	myosin light chain kinase	35257	0.15
chr14_61447182_61447373	0.28	TRMT5	tRNA methyltransferase 5	492	0.5
chr17_63341710_63341861	0.28	ENSG00000265189	.	74993	0.12
chr1_221910890_221911087	0.28	DUSP10	dual specificity phosphatase 10	186	0.97
chr6_24667419_24667634	0.28	ACOT13	acyl-CoA thioesterase 13	227	0.53
chr5_128429913_128430155	0.27	ISOC1	isochorismatase domain containing 1	410	0.87
chr20_31988038_31988189	0.27	CDK5RAP1	CDK5 regulatory subunit associated protein 1	1210	0.46
chr5_5419342_5419575	0.27	KIAA0947	KIAA0947	3349	0.39
chr17_47077722_47077873	0.27	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	2689	0.14
chr14_58862127_58862433	0.26	RP11-517O13.3		79	0.8
chr11_72449633_72449911	0.26	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	11599	0.12
chr9_107755904_107756060	0.26	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	65464	0.11
chr7_101930639_101930983	0.26	SH2B2	SH2B adaptor protein 2	2359	0.2
chr10_53459424_53459629	0.26	CSTF2T	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	171	0.97
chr11_118939891_118940176	0.25	VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)	1540	0.15
chr15_93446443_93446658	0.25	ENSG00000264173	.	1079	0.38
chr16_22202801_22203159	0.25	EEF2K	eukaryotic elongation factor-2 kinase	14623	0.17
chr6_26313507_26313734	0.25	HIST1H4H	histone cluster 1, H4h	27858	0.07
chr7_89896255_89896406	0.25	AC002064.4		3200	0.19
chr6_133133816_133133967	0.25	RPS12	ribosomal protein S12	1689	0.22
chr13_98112435_98112620	0.25	RAP2A	RAP2A, member of RAS oncogene family	26051	0.24
chr8_32559587_32559738	0.25	NRG1	neuregulin 1	19609	0.29
chr18_71857391_71857542	0.25	TIMM21	translocase of inner mitochondrial membrane 21 homolog (yeast)	35056	0.15
chr7_131338473_131338624	0.25	PODXL	podocalyxin-like	97172	0.08
chr4_81189028_81189189	0.25	FGF5	fibroblast growth factor 5	1315	0.54
chr1_201857476_201857627	0.25	SHISA4	shisa family member 4	285	0.85
chr1_90460194_90460489	0.25	ZNF326	zinc finger protein 326	333	0.91
chr11_119953470_119953621	0.25	TRIM29	tripartite motif containing 29	38063	0.18
chr1_109504839_109504990	0.25	CLCC1	chloride channel CLIC-like 1	1158	0.34
chr12_52346063_52346405	0.25	ACVR1B	activin A receptor, type IB	706	0.62
chr5_122110815_122111189	0.25	SNX2	sorting nexin 2	104	0.94
chr8_27630129_27630324	0.25	CCDC25	coiled-coil domain containing 25	69	0.89
chr5_172185603_172185754	0.25	RP11-779O18.1		449	0.76
chrX_135848946_135849996	0.25	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	31	0.98
chr1_240256340_240256520	0.25	FMN2	formin 2	1250	0.57
chr9_125796489_125796713	0.25	GPR21	G protein-coupled receptor 21	205	0.86
chr12_53846681_53847472	0.25	PCBP2	poly(rC) binding protein 2	448	0.72
chr1_89591012_89591781	0.25	GBP2	guanylate binding protein 2, interferon-inducible	401	0.85
chr22_40571850_40572001	0.24	TNRC6B	trinucleotide repeat containing 6B	2004	0.43
chr15_79328270_79328421	0.24	RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	30338	0.17
chr16_66586477_66586958	0.24	CKLF-CMTM1	CKLF-CMTM1 readthrough	165	0.44
chr6_146284922_146285161	0.24	SHPRH	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	192	0.97
chr19_55765035_55765186	0.24	PPP6R1	protein phosphatase 6, regulatory subunit 1	2027	0.15
chr17_18313829_18314117	0.24	AL353997.4		10160	0.11
chr20_4954300_4954516	0.24	SLC23A2	solute carrier family 23 (ascorbic acid transporter), member 2	27737	0.17
chrX_129065192_129065438	0.24	UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	17976	0.18
chr4_140375324_140375815	0.24	RP11-83A24.2		381	0.62
chr1_170640082_170640341	0.24	PRRX1	paired related homeobox 1	7133	0.3
chr2_162849046_162849197	0.24	ENSG00000253046	.	73829	0.1
chr7_114459536_114459687	0.24	MDFIC	MyoD family inhibitor domain containing	102598	0.08
chr2_177042560_177043156	0.24	HOXD-AS1	HOXD cluster antisense RNA 1	5	0.95
chr10_31608301_31608721	0.24	ENSG00000237036	.	109	0.8
chr15_60898079_60898454	0.23	RORA	RAR-related orphan receptor A	12941	0.23
chr5_154078594_154078745	0.23	ENSG00000263478	.	4675	0.17
chr11_85358415_85358894	0.23	TMEM126A	transmembrane protein 126A	367	0.83
chr12_68043814_68044335	0.23	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	612	0.81
chr2_55647724_55647875	0.23	CCDC88A	coiled-coil domain containing 88A	742	0.62
chrX_102631036_102631748	0.23	NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1	57	0.97
chr7_82201510_82201661	0.23	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	128471	0.06
chr9_119713843_119714110	0.23	ENSG00000265662	.	147310	0.04
chr19_10811895_10812062	0.23	QTRT1	queuine tRNA-ribosyltransferase 1	149	0.93
chr13_99160815_99160995	0.23	STK24	serine/threonine kinase 24	10616	0.23
chr20_12990547_12990774	0.23	SPTLC3	serine palmitoyltransferase, long chain base subunit 3	663	0.83
chr15_64679591_64679870	0.23	TRIP4	thyroid hormone receptor interactor 4	273	0.85
chr4_1241678_1241899	0.23	CTBP1	C-terminal binding protein 1	740	0.5
chr20_9073959_9074110	0.23	PLCB4	phospholipase C, beta 4	24286	0.22
chrX_87155513_87155664	0.23	ENSG00000252016	.	248205	0.02
chr9_133712337_133712924	0.23	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	2177	0.35
chr1_67600256_67600407	0.23	C1orf141	chromosome 1 open reading frame 141	308	0.89
chr12_133404529_133404680	0.22	GOLGA3	golgin A3	684	0.62
chr18_20274804_20275027	0.22	RP11-370A5.1		36613	0.17
chr6_132179827_132179978	0.22	ENSG00000200895	.	38428	0.14
chr1_206645642_206645925	0.22	IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	1945	0.27
chr3_155393866_155394017	0.22	PLCH1	phospholipase C, eta 1	113	0.98
chr3_16927344_16927610	0.22	PLCL2	phospholipase C-like 2	1025	0.65
chr19_16461941_16462107	0.22	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	10740	0.14
chr20_48955472_48955638	0.22	ENSG00000244376	.	90465	0.08
chr1_163845312_163845463	0.22	ENSG00000212538	.	47520	0.2
chr2_175546375_175546968	0.22	WIPF1	WAS/WASL interacting protein family, member 1	928	0.66
chr12_49450678_49450829	0.22	KMT2D	lysine (K)-specific methyltransferase 2D	1646	0.2
chr12_125473806_125474002	0.22	DHX37	DEAH (Asp-Glu-Ala-His) box polypeptide 37	237	0.93
chr1_12139606_12139757	0.22	ENSG00000201135	.	1640	0.3
chr14_103481209_103481581	0.22	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	42404	0.13
chr8_75234014_75234228	0.22	JPH1	junctophilin 1	558	0.76
chr5_175788940_175789140	0.22	KIAA1191	KIAA1191	69	0.94
chr15_34627792_34628213	0.21	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	1043	0.38
chr20_13619088_13619556	0.21	TASP1	taspase, threonine aspartase, 1	228	0.96
chr8_124829666_124829817	0.21	FER1L6	fer-1-like 6 (C. elegans)	34486	0.17
chr11_111957062_111957410	0.21	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	261	0.49
chr3_125931550_125931701	0.21	ALDH1L1-AS2	ALDH1L1 antisense RNA 2	5527	0.19
chr5_14983876_14984027	0.21	ENSG00000212036	.	73202	0.11
chr3_177624174_177624369	0.21	ENSG00000199858	.	101296	0.09
chrX_12992120_12992286	0.21	TMSB4X	thymosin beta 4, X-linked	1024	0.6
chrX_118924681_118925547	0.21	RPL39	ribosomal protein L39	492	0.74
chr2_216286742_216286974	0.21	FN1	fibronectin 1	13932	0.21
chr2_241497193_241497674	0.21	ANKMY1	ankyrin repeat and MYND domain containing 1	5	0.96
chr21_35748199_35748651	0.21	SMIM11	small integral membrane protein 11	522	0.54
chr5_168167573_168167764	0.21	ENSG00000207739	.	27592	0.17
chr12_47219516_47219750	0.21	SLC38A4	solute carrier family 38, member 4	135	0.98
chr18_60520045_60520196	0.21	AC015989.2		14172	0.2
chr4_119201779_119201930	0.21	ENSG00000269893	.	1509	0.54
chr7_143083179_143083339	0.21	ZYX	zyxin	3166	0.14
chr15_83420399_83420550	0.21	RP11-752G15.6		1138	0.35
chr19_47731656_47732088	0.20	ENSG00000265134	.	1673	0.27
chr18_72162856_72163393	0.20	CNDP2	CNDP dipeptidase 2 (metallopeptidase M20 family)	73	0.98
chr4_144434579_144434842	0.20	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	94	0.95
chr11_65480098_65480381	0.20	KAT5	K(lysine) acetyltransferase 5	37	0.95
chr1_149899868_149900298	0.20	SF3B4	splicing factor 3b, subunit 4, 49kDa	153	0.9

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF282

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.3	GO:0030091	protein repair(GO:0030091)
0.1	0.3	GO:0006565	L-serine catabolic process(GO:0006565)
0.1	0.4	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.4	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.1	0.4	GO:0017085	response to insecticide(GO:0017085)
0.1	0.2	GO:0033345	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.1	0.2	GO:0002328	pro-B cell differentiation(GO:0002328)
0.1	0.2	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.1	0.4	GO:0016584	nucleosome positioning(GO:0016584)
0.1	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1	0.2	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.5	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.0	0.2	GO:0033088	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.2	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.2	GO:0001757	somite specification(GO:0001757)
0.0	0.2	GO:0010664	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.2	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.4	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.3	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0014052	regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0	0.2	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.2	GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.3	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0090281	negative regulation of calcium ion import(GO:0090281)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.2	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.2	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.0	0.3	GO:0006385	transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.2	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.1	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0043558	regulation of translational initiation in response to stress(GO:0043558)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.0	GO:0014051	gamma-aminobutyric acid secretion(GO:0014051)
0.0	0.2	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.2	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.4	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.1	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.2	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.4	GO:0044766	multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.2	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.3	GO:0006400	tRNA modification(GO:0006400)
0.0	0.5	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	0.0	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.1	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.4	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.0	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.0	GO:0021830	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.0	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.0	0.0	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.1	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.0	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.2	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0031935	regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0030157	pancreatic juice secretion(GO:0030157)
0.0	0.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.0	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:1903020	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.1	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.0	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.0	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0071453	cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.0	0.1	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0055012	ventricular cardiac muscle cell differentiation(GO:0055012)
0.0	0.0	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	0.3	GO:0016589	NURF complex(GO:0016589)
0.1	0.2	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.4	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.3	GO:0030677	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.2	GO:0045281	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.3	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.2	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.7	GO:0005884	actin filament(GO:0005884)
0.0	0.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.0	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.0	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.2	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0000801	central element(GO:0000801)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0000795	synaptonemal complex(GO:0000795)
0.0	0.2	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.2	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.6	GO:0000786	nucleosome(GO:0000786)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.3	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1	0.3	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.3	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.5	GO:0031491	nucleosome binding(GO:0031491)
0.1	0.4	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.1	GO:0015216	adenine nucleotide transmembrane transporter activity(GO:0000295) purine nucleotide transmembrane transporter activity(GO:0015216)
0.1	0.3	GO:0052743	inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.1	0.2	GO:0048039	ubiquinone binding(GO:0048039)
0.1	0.4	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.3	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.2	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.2	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.2	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.3	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.3	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.3	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.3	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.2	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.1	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.3	GO:0016289	CoA hydrolase activity(GO:0016289)
0.0	0.2	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0061659	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.2	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.1	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.2	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0015205	nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.5	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.0	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0008200	ion channel inhibitor activity(GO:0008200)
0.0	0.1	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.4	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.1	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.2	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
1.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.8	PID ATM PATHWAY	ATM pathway
0.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.5	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID ARF 3PATHWAY	Arf1 pathway
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	PID CDC42 PATHWAY	CDC42 signaling events
0.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.5	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.2	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.1	REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.2	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.2	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.5	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.2	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC