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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF410

Z-value: 0.53

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Transcription factors associated with ZNF410

Gene Symbol	Gene ID	Gene Info
ZNF410 Ensembl NCBI GeneCards UniProt	ENSG00000119725.13	ZNF410

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF410	chr14_74352825_74353319	248	0.860110	-0.26	5.0e-01	Click!
ZNF410	chr14_74354228_74354413	559	0.618596	-0.25	5.2e-01	Click!
ZNF410	chr14_74353534_74354170	91	0.943032	-0.15	7.0e-01	Click!

Activity of the ZNF410 motif across conditions

Conditions sorted by the z-value of the ZNF410 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_21023989_21024197	0.34	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2	7515	0.22
chr12_6716856_6717254	0.31	CHD4	chromodomain helicase DNA binding protein 4	413	0.67
chr8_108507547_108507698	0.31	ANGPT1	angiopoietin 1	399	0.92
chr10_62331691_62331925	0.28	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	613	0.85
chr16_50316518_50316669	0.24	ADCY7	adenylate cyclase 7	3155	0.26
chr2_54825743_54825894	0.23	SPTBN1	spectrin, beta, non-erythrocytic 1	40287	0.14
chr12_94599811_94599962	0.22	RP11-74K11.2		20066	0.19
chr7_5682827_5682978	0.21	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	37190	0.13
chr7_50256147_50256298	0.20	AC020743.2		73803	0.1
chr12_6722182_6722818	0.20	CHD4	chromodomain helicase DNA binding protein 4	5858	0.09
chr14_35605928_35606079	0.20	KIAA0391	KIAA0391	14038	0.19
chr8_53372458_53372609	0.16	ST18	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	50168	0.17
chr12_66274639_66274849	0.15	RP11-366L20.2	Uncharacterized protein	614	0.73
chr11_128586182_128586446	0.15	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	20396	0.17
chr6_16695295_16695446	0.15	RP1-151F17.1		65999	0.13
chr6_27104872_27105023	0.14	HIST1H4I	histone cluster 1, H4i	2129	0.18
chr3_101555921_101556072	0.13	NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	9159	0.19
chr2_218798521_218798672	0.12	TNS1	tensin 1	3289	0.29
chr2_201612300_201612519	0.12	ENSG00000201737	.	27898	0.13
chr17_79882093_79882377	0.12	MAFG	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	827	0.26
chr1_173175749_173175900	0.12	TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	628	0.81
chr12_69743882_69744071	0.12	LYZ	lysozyme	1810	0.3
chr2_201924342_201924493	0.11	NDUFB3	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa	11739	0.13
chr3_178866443_178867773	0.11	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	207	0.94
chr3_101447790_101447941	0.11	CEP97	centrosomal protein 97kDa	4366	0.17
chr19_48747671_48748205	0.10	CARD8	caspase recruitment domain family, member 8	3618	0.15
chr17_35854577_35854849	0.10	DUSP14	dual specificity phosphatase 14	3143	0.25
chr9_115981849_115982001	0.10	FKBP15	FK506 binding protein 15, 133kDa	1673	0.28
chr10_114716477_114716628	0.10	RP11-57H14.2		4918	0.24
chr3_128958405_128958556	0.09	COPG1	coatomer protein complex, subunit gamma 1	9969	0.15
chr5_36725036_36725307	0.09	CTD-2353F22.1		104	0.98
chr4_154178413_154178564	0.09	TRIM2	tripartite motif containing 2	74	0.97
chr4_151509067_151509271	0.09	MAB21L2	mab-21-like 2 (C. elegans)	6092	0.23
chr7_77200176_77200327	0.09	PTPN12	protein tyrosine phosphatase, non-receptor type 12	157	0.97
chr2_161243980_161244427	0.09	ENSG00000252465	.	9276	0.21
chr5_111110911_111111062	0.08	NREP	neuronal regeneration related protein	17071	0.21
chr6_15421648_15421799	0.08	JARID2	jumonji, AT rich interactive domain 2	20634	0.24
chr6_170921254_170921775	0.08	PDCD2	programmed cell death 2	27766	0.19
chr2_236467191_236467342	0.07	ENSG00000221704	.	13309	0.22
chr11_74561071_74561376	0.07	ENSG00000242999	.	4268	0.2
chr10_97501781_97501932	0.07	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	13553	0.21
chr3_156266030_156266252	0.07	SSR3	signal sequence receptor, gamma (translocon-associated protein gamma)	5773	0.24
chr12_46776420_46777113	0.07	SLC38A2	solute carrier family 38, member 2	10116	0.24
chr5_176901024_176901292	0.07	DBN1	drebrin 1	244	0.85
chr5_124090344_124090580	0.07	ZNF608	zinc finger protein 608	5962	0.15
chr14_73927569_73927740	0.07	ENSG00000251393	.	1475	0.32
chr2_48599257_48599408	0.07	ENSG00000251889	.	31367	0.18
chr1_39624513_39624771	0.07	ENSG00000222378	.	4674	0.21
chr4_40561734_40561885	0.06	RBM47	RNA binding motif protein 47	43819	0.15
chr9_83413109_83413260	0.06	ENSG00000221581	.	63940	0.16
chr13_21654404_21654812	0.06	LATS2	large tumor suppressor kinase 2	18922	0.14
chr11_57334584_57335055	0.06	UBE2L6	ubiquitin-conjugating enzyme E2L 6	20	0.96
chr16_17087479_17087630	0.06	CTD-2576D5.4		140807	0.05
chr10_111659026_111659177	0.06	XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	8476	0.22
chr6_1841402_1841553	0.06	FOXC1	forkhead box C1	230796	0.02
chr5_14154391_14154790	0.06	TRIO	trio Rho guanine nucleotide exchange factor	10761	0.32
chr14_56584316_56584807	0.06	PELI2	pellino E3 ubiquitin protein ligase family member 2	29	0.98
chr13_78410734_78410885	0.05	EDNRB	endothelin receptor type B	82136	0.08
chr11_10064267_10064418	0.05	SBF2	SET binding factor 2	49691	0.16
chr3_119922105_119922256	0.05	ENSG00000206721	.	6987	0.22
chr10_116582241_116583014	0.05	FAM160B1	family with sequence similarity 160, member B1	1098	0.64
chr2_45794929_45795131	0.05	SRBD1	S1 RNA binding domain 1	124	0.96
chr6_163826222_163826373	0.05	QKI	QKI, KH domain containing, RNA binding	9378	0.32
chr19_1064805_1065015	0.05	HMHA1	histocompatibility (minor) HA-1	1012	0.32
chr8_127989397_127989548	0.05	ENSG00000212451	.	305705	0.01
chr8_86371428_86371579	0.05	RP11-317J10.2		3780	0.21
chr3_63957905_63958056	0.05	ATXN7	ataxin 7	4560	0.17
chr6_85134970_85135121	0.05	KIAA1009	KIAA1009	197692	0.03
chr14_67828227_67828378	0.04	EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	1029	0.38
chr6_41666551_41666729	0.04	TFEB	transcription factor EB	7038	0.13
chr10_7670560_7670711	0.04	ITIH5	inter-alpha-trypsin inhibitor heavy chain family, member 5	9012	0.26
chr12_84274084_84274235	0.04	ENSG00000221148	.	303068	0.01
chr5_40615963_40616141	0.04	ENSG00000199552	.	39013	0.18
chrX_143576959_143577110	0.04	ENSG00000201912	.	561594	0.0
chr11_15179065_15179216	0.04	INSC	inscuteable homolog (Drosophila)	8486	0.3
chr2_65291860_65292299	0.04	CEP68	centrosomal protein 68kDa	8480	0.18
chr20_36629792_36630028	0.04	TTI1	TELO2 interacting protein 1	12395	0.17
chrX_153637082_153637306	0.04	DNASE1L1	deoxyribonuclease I-like 1	418	0.63
chr5_172261659_172261898	0.04	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	364	0.87
chr8_123440615_123440780	0.04	ENSG00000238901	.	242833	0.02
chr12_123199549_123199700	0.04	HCAR3	hydroxycarboxylic acid receptor 3	1815	0.27
chr12_109118598_109118801	0.04	CORO1C	coronin, actin binding protein, 1C	5628	0.17
chr2_202519598_202519749	0.04	ENSG00000222972	.	8234	0.16
chr5_132385127_132385278	0.04	HSPA4	heat shock 70kDa protein 4	2452	0.27
chr1_206137311_206137809	0.04	RP11-312O7.2		268	0.52
chrX_24073135_24073641	0.04	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	300	0.91
chr4_22516047_22517223	0.04	GPR125	G protein-coupled receptor 125	985	0.72
chr7_17018287_17018438	0.03	AGR3	anterior gradient 3	96751	0.08
chr9_116384320_116384471	0.03	RGS3	regulator of G-protein signaling 3	28629	0.19
chr9_41563760_41563911	0.03	SPATA31A5	SPATA31 subfamily A, member 5	63156	0.15
chr19_36618863_36619073	0.03	CAPNS1	calpain, small subunit 1	11509	0.09
chr20_23067023_23067351	0.03	CD93	CD93 molecule	210	0.93
chr1_98496294_98496445	0.03	ENSG00000225206	.	14538	0.29
chr22_37679105_37679462	0.03	CYTH4	cytohesin 4	755	0.62
chr12_13499997_13500148	0.03	C12orf36	chromosome 12 open reading frame 36	29292	0.21
chr12_65071079_65071230	0.03	AC025262.1	Mesenchymal stem cell protein DSC96; Uncharacterized protein	19175	0.13
chr13_28997424_28997626	0.03	FLT1	fms-related tyrosine kinase 1	71707	0.12
chr15_85295872_85296023	0.03	RP11-7M10.2		406	0.79
chr1_225942852_225943140	0.03	ENSG00000223306	.	14019	0.14
chr1_175323766_175323917	0.03	RP3-518E13.2		47487	0.16
chr1_43416112_43416263	0.03	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	8313	0.19
chr7_87504669_87504826	0.02	DBF4	DBF4 homolog (S. cerevisiae)	797	0.47
chr5_178956987_178957198	0.02	RUFY1	RUN and FYVE domain containing 1	20467	0.17
chr13_42151532_42151903	0.02	ENSG00000264190	.	9186	0.26
chr9_39418756_39418907	0.02	CTD-2173L22.4		42860	0.18
chr10_61661518_61661669	0.02	CCDC6	coiled-coil domain containing 6	4821	0.3
chrX_69512839_69512990	0.02	KIF4A	kinesin family member 4A	2974	0.15
chr5_119488092_119488243	0.02	ENSG00000251975	.	185181	0.03
chr10_127511437_127512239	0.02	UROS	uroporphyrinogen III synthase	21	0.79
chr8_74904321_74904899	0.02	LY96	lymphocyte antigen 96	949	0.5
chr8_94752281_94753315	0.02	RBM12B	RNA binding motif protein 12B	148	0.72
chr7_13920022_13920238	0.02	ETV1	ets variant 1	105936	0.08
chr17_57701437_57701588	0.02	CLTC	clathrin, heavy chain (Hc)	4219	0.23
chrX_64925761_64925912	0.02	MSN	moesin	38299	0.22
chr10_134363355_134363506	0.02	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	11787	0.21
chr9_39948000_39948151	0.02	SPATA31A2	SPATA31 subfamily A, member 2	63100	0.14
chr2_62638898_62639095	0.02	ENSG00000241625	.	79317	0.09
chr14_92571968_92572886	0.02	ATXN3	ataxin 3	479	0.77
chr17_66437196_66437347	0.02	WIPI1	WD repeat domain, phosphoinositide interacting 1	7559	0.21
chr11_8008996_8010000	0.02	EIF3F	eukaryotic translation initiation factor 3, subunit F	610	0.64
chr2_210868078_210868268	0.02	RPE	ribulose-5-phosphate-3-epimerase	787	0.63
chr1_16177042_16177194	0.02	RP11-169K16.9		2476	0.21
chr13_46741782_46741933	0.02	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	797	0.56
chr15_40226407_40226907	0.02	EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4	280	0.88
chr11_85778298_85779603	0.02	PICALM	phosphatidylinositol binding clathrin assembly protein	872	0.65
chr9_113598301_113598563	0.02	MUSK	muscle, skeletal, receptor tyrosine kinase	60805	0.12
chr19_13023816_13024331	0.02	SYCE2	synaptonemal complex central element protein 2	6017	0.06
chr12_114284871_114285022	0.02	RP11-780K2.1		85428	0.1
chr5_72111935_72112277	0.02	TNPO1	transportin 1	33	0.8
chr1_40847512_40847991	0.02	SMAP2	small ArfGAP2	7431	0.18
chr8_134090212_134090363	0.01	SLA	Src-like-adaptor	17684	0.22
chr3_125635457_125636442	0.01	FAM86JP	family with sequence similarity 86, member J, pseudogene	482	0.8
chr15_102061524_102061675	0.01	PCSK6	proprotein convertase subtilisin/kexin type 6	31412	0.2
chr9_129252632_129253068	0.01	ENSG00000221768	.	40420	0.14
chr3_168825087_168825238	0.01	MECOM	MDS1 and EVI1 complex locus	20660	0.29
chr1_221209086_221209419	0.01	HLX	H2.0-like homeobox	154668	0.04
chr1_143913778_143914315	0.01	FAM72D	family with sequence similarity 72, member D	903	0.56
chr18_32663220_32663371	0.01	MAPRE2	microtubule-associated protein, RP/EB family, member 2	41681	0.2
chr19_9524867_9525018	0.01	ZNF266	zinc finger protein 266	4815	0.19
chr7_37759942_37760093	0.01	GPR141	G protein-coupled receptor 141	19979	0.23
chr14_21851512_21852227	0.01	SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	271	0.69
chr5_95144892_95145187	0.01	GLRX	glutaredoxin (thioltransferase)	13376	0.15
chr6_160450858_160451009	0.01	AIRN	antisense of IGF2R non-protein coding RNA	22237	0.21
chr8_37888134_37889006	0.01	EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	711	0.62
chr15_52788839_52789035	0.01	MYO5A	myosin VA (heavy chain 12, myoxin)	32101	0.18
chr22_46134071_46134222	0.01	ATXN10	ataxin 10	473	0.84
chr6_71544283_71544434	0.01	SMAP1	small ArfGAP 1	61266	0.15
chr10_70165992_70166978	0.01	RUFY2	RUN and FYVE domain containing 2	461	0.8
chr9_14309575_14309740	0.01	NFIB	nuclear factor I/B	1645	0.46
chr14_71066645_71067347	0.01	MED6	mediator complex subunit 6	364	0.87
chr13_46742646_46742820	0.01	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	79	0.95
chr6_121760674_121760877	0.01	GJA1	gap junction protein, alpha 1, 43kDa	3937	0.22
chr14_92874571_92874722	0.01	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	77	0.98
chr1_231671479_231671630	0.01	TSNAX	translin-associated factor X	7153	0.2
chr17_13689312_13689463	0.01	ENSG00000236088	.	6480	0.33
chr14_32842058_32842209	0.01	AKAP6	A kinase (PRKA) anchor protein 6	43527	0.15
chr13_86099472_86099623	0.01	ENSG00000207012	.	59441	0.17
chr19_58521386_58521539	0.01	ZNF606	zinc finger protein 606	6745	0.11
chr2_60755895_60756046	0.01	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	24570	0.2
chr4_37978441_37978791	0.01	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	315	0.92
chr3_88483370_88483521	0.01	ENSG00000207316	.	3104	0.41
chr9_80408593_80408744	0.01	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	29247	0.25
chr1_27079827_27079978	0.00	ENSG00000266138	.	10213	0.13
chr13_103353320_103353471	0.00	METTL21C	methyltransferase like 21C	6541	0.16
chr1_87803835_87803986	0.00	LMO4	LIM domain only 4	6559	0.32
chr8_93547538_93547689	0.00	ENSG00000221172	.	99950	0.09
chr18_55469401_55470160	0.00	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	547	0.82
chr16_14800704_14800855	0.00	RP11-82O18.2		133	0.93
chr12_95596867_95597053	0.00	FGD6	FYVE, RhoGEF and PH domain containing 6	14195	0.18
chr12_57940971_57941264	0.00	DCTN2	dynactin 2 (p50)	3	0.94
chr3_102392529_102392885	0.00	ENSG00000201065	.	81307	0.12
chr8_42409378_42409529	0.00	SMIM19	small integral membrane protein 19	7882	0.18
chr14_24611030_24611338	0.00	EMC9	ER membrane protein complex subunit 9	387	0.61
chrX_78412852_78413003	0.00	GPR174	G protein-coupled receptor 174	13542	0.31
chr18_43554027_43554236	0.00	EPG5	ectopic P-granules autophagy protein 5 homolog (C. elegans)	6891	0.21
chr16_53751617_53751768	0.00	FTO	fat mass and obesity associated	13598	0.22
chr2_71763544_71763695	0.00	DYSF	dysferlin	69787	0.12
chr12_121726859_121727365	0.00	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	7377	0.21
chr12_100988036_100988187	0.00	GAS2L3	growth arrest-specific 2 like 3	715	0.75
chr12_62657622_62657800	0.00	USP15	ubiquitin specific peptidase 15	3502	0.25
chr6_107816329_107816751	0.00	SOBP	sine oculis binding protein homolog (Drosophila)	5378	0.23
chr10_5509058_5509209	0.00	NET1	neuroepithelial cell transforming 1	20559	0.14
chr11_114034692_114034843	0.00	ENSG00000221112	.	77116	0.09
chr10_126368779_126368930	0.00	FAM53B-AS1	FAM53B antisense RNA 1	23340	0.19
chr17_37557069_37557922	0.00	FBXL20	F-box and leucine-rich repeat protein 20	381	0.59
chr2_179279129_179279546	0.00	AC009948.5		587	0.72
chr15_48469342_48470564	0.00	MYEF2	myelin expression factor 2	597	0.66

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF410

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	GO:0001849	complement component C1q binding(GO:0001849)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins