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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF423

Z-value: 0.63

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Transcription factors associated with ZNF423

Gene Symbol	Gene ID	Gene Info
ZNF423 Ensembl NCBI GeneCards UniProt	ENSG00000102935.7	ZNF423

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF423	chr16_49629926_49630278	44661	0.181152	0.85	4.0e-03	Click!
ZNF423	chr16_49654580_49654731	20108	0.244998	0.75	1.9e-02	Click!
ZNF423	chr16_49697543_49697694	518	0.835648	0.72	2.8e-02	Click!
ZNF423	chr16_49862024_49862175	1178	0.547025	0.71	3.0e-02	Click!
ZNF423	chr16_49698067_49698218	6	0.984072	0.69	4.1e-02	Click!

Activity of the ZNF423 motif across conditions

Conditions sorted by the z-value of the ZNF423 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_150464397_150464642	0.30	PPP1R14C	protein phosphatase 1, regulatory (inhibitor) subunit 14C	307	0.91
chr3_114173030_114173441	0.29	ZBTB20	zinc finger and BTB domain containing 20	295	0.94
chr13_95619763_95620412	0.28	ENSG00000252335	.	51402	0.18
chr22_30641304_30641455	0.28	RP1-102K2.8		605	0.52
chr1_14924992_14926197	0.28	KAZN	kazrin, periplakin interacting protein	381	0.93
chr17_17725795_17725961	0.28	SREBF1	sterol regulatory element binding transcription factor 1	1054	0.42
chr12_66216582_66216994	0.27	HMGA2	high mobility group AT-hook 2	1123	0.55
chr1_20915430_20915891	0.27	CDA	cytidine deaminase	219	0.93
chr10_63212172_63213035	0.27	RP11-809M12.1		206	0.83
chr19_41725215_41725482	0.26	AXL	AXL receptor tyrosine kinase	208	0.89
chr6_150464730_150464955	0.25	PPP1R14C	protein phosphatase 1, regulatory (inhibitor) subunit 14C	630	0.74
chrX_39548256_39548819	0.25	ENSG00000263730	.	28067	0.24
chr3_133614813_133615159	0.24	RAB6B	RAB6B, member RAS oncogene family	306	0.92
chr13_114541163_114541465	0.24	GAS6	growth arrest-specific 6	2297	0.34
chr1_27928484_27928752	0.24	AHDC1	AT hook, DNA binding motif, containing 1	1484	0.34
chr8_89340038_89340774	0.24	MMP16	matrix metallopeptidase 16 (membrane-inserted)	152	0.73
chr20_6032553_6033205	0.23	LRRN4	leucine rich repeat neuronal 4	1816	0.35
chr2_241860515_241860848	0.22	AC104809.3	Protein LOC728763	1305	0.38
chr19_45147190_45148055	0.22	PVR	poliovirus receptor	225	0.9
chr2_127976513_127977351	0.21	CYP27C1	cytochrome P450, family 27, subfamily C, polypeptide 1	722	0.74
chr2_113593127_113593420	0.21	IL1B	interleukin 1, beta	738	0.63
chr19_1240029_1240222	0.21	ATP5D	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	1624	0.18
chr19_36024645_36024970	0.20	GAPDHS	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	493	0.62
chr1_208132304_208132634	0.20	CD34	CD34 molecule	47722	0.19
chr11_64122826_64123177	0.20	RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	3619	0.11
chr20_57090585_57090835	0.20	APCDD1L	adenomatosis polyposis coli down-regulated 1-like	523	0.83
chr19_54483356_54483962	0.20	ENSG00000215998	.	1902	0.19
chr7_20370368_20370519	0.19	ITGB8	integrin, beta 8	118	0.93
chr4_74735225_74735723	0.19	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	353	0.85
chr1_65991788_65991976	0.19	LEPR	leptin receptor	39347	0.14
chr10_72976782_72977411	0.19	UNC5B-AS1	UNC5B antisense RNA 1	486	0.73
chr22_29598883_29599280	0.19	EMID1	EMI domain containing 1	2759	0.2
chr4_156681206_156681472	0.19	GUCY1B3	guanylate cyclase 1, soluble, beta 3	728	0.72
chr7_23508285_23508467	0.19	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	1710	0.33
chr2_218874347_218874698	0.19	TNS1	tensin 1	6804	0.19
chr22_46482353_46482522	0.19	FLJ27365	hsa-mir-4763	554	0.6
chr13_96296247_96296898	0.18	DZIP1	DAZ interacting zinc finger protein 1	372	0.89
chr16_88870757_88870966	0.18	CDT1	chromatin licensing and DNA replication factor 1	1240	0.28
chr12_81330378_81331020	0.17	LIN7A	lin-7 homolog A (C. elegans)	784	0.37
chr17_8295251_8295402	0.17	RNF222	ring finger protein 222	1481	0.24
chr21_35831656_35831815	0.17	KCNE1	potassium voltage-gated channel, Isk-related family, member 1	167	0.94
chr7_43288672_43288925	0.17	AC004692.4		43	0.98
chr7_73704780_73705014	0.17	CLIP2	CAP-GLY domain containing linker protein 2	1092	0.51
chr2_97136526_97136687	0.17	NEURL3	neuralized E3 ubiquitin protein ligase 3	30055	0.16
chr19_44905150_44906080	0.17	ZNF285	zinc finger protein 285	126	0.54
chr8_55065813_55066181	0.17	ENSG00000251835	.	555	0.79
chr4_74809740_74810515	0.17	PF4	platelet factor 4	37714	0.11
chr17_71301523_71301822	0.17	CDC42EP4	CDC42 effector protein (Rho GTPase binding) 4	5875	0.2
chr16_4424352_4424847	0.16	VASN	vasorin	2750	0.17
chr19_10947512_10947663	0.16	C19orf38	chromosome 19 open reading frame 38	336	0.63
chr4_62067084_62067588	0.16	LPHN3	latrophilin 3	360	0.94
chr4_74903896_74904220	0.16	CXCL3	chemokine (C-X-C motif) ligand 3	348	0.83
chr7_47620495_47620884	0.16	TNS3	tensin 3	540	0.86
chr15_101629242_101629566	0.16	RP11-505E24.2		3133	0.3
chr7_37960238_37961117	0.15	EPDR1	ependymin related 1	245	0.94
chr10_106079408_106079559	0.15	RP11-127L20.5		7584	0.13
chr10_114712061_114712425	0.15	RP11-57H14.2		609	0.69
chr17_37729930_37730438	0.15	ENSG00000222777	.	27687	0.12
chr4_74734701_74735215	0.15	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	163	0.94
chr13_33804184_33804599	0.15	STARD13	StAR-related lipid transfer (START) domain containing 13	24248	0.2
chr5_9544908_9545592	0.15	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	937	0.56
chr19_17579873_17580031	0.15	SLC27A1	solute carrier family 27 (fatty acid transporter), member 1	374	0.71
chr5_167792475_167792729	0.15	WWC1	WW and C2 domain containing 1	5824	0.29
chrX_19140154_19140583	0.15	GPR64	G protein-coupled receptor 64	211	0.97
chr18_500844_501279	0.15	COLEC12	collectin sub-family member 12	339	0.89
chr16_70719186_70719575	0.15	MTSS1L	metastasis suppressor 1-like	589	0.67
chr20_1298176_1298327	0.15	SDCBP2	syndecan binding protein (syntenin) 2	3934	0.16
chr1_78354680_78354975	0.14	NEXN-AS1	NEXN antisense RNA 1	397	0.54
chr11_66082073_66082224	0.14	RP11-867G23.13		1824	0.12
chr18_11149170_11149978	0.14	PIEZO2	piezo-type mechanosensitive ion channel component 2	987	0.72
chr9_140301738_140301959	0.14	ENSG00000272272	.	13748	0.11
chr17_7483283_7483711	0.14	CD68	CD68 molecule	316	0.62
chr13_114541513_114541687	0.14	GAS6	growth arrest-specific 6	2583	0.32
chr1_54844833_54844984	0.14	SSBP3	single stranded DNA binding protein 3	26269	0.19
chr9_18438384_18438699	0.14	ADAMTSL1	ADAMTS-like 1	35351	0.23
chr9_112542645_112542955	0.13	AKAP2	A kinase (PRKA) anchor protein 2	31	0.37
chr7_100880679_100880896	0.13	CLDN15	claudin 15	254	0.85
chr17_58164259_58164533	0.13	HEATR6	HEAT repeat containing 6	8104	0.14
chr22_50698815_50699396	0.13	MAPK12	mitogen-activated protein kinase 12	632	0.49
chr13_27757022_27757206	0.13	USP12-AS2	USP12 antisense RNA 2 (head to head)	10718	0.14
chr5_115911326_115911646	0.13	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	856	0.75
chr12_43945597_43946279	0.13	ADAMTS20	ADAM metallopeptidase with thrombospondin type 1 motif, 20	214	0.97
chr1_156072742_156072967	0.13	LMNA	lamin A/C	11607	0.1
chr11_69460044_69460271	0.13	CCND1	cyclin D1	4183	0.25
chr5_176935395_176936034	0.13	DOK3	docking protein 3	1113	0.32
chr2_14772882_14773213	0.13	FAM84A	family with sequence similarity 84, member A	223	0.94
chr7_101268427_101268664	0.13	MYL10	myosin, light chain 10, regulatory	4031	0.33
chr12_32551927_32552214	0.13	FGD4	FYVE, RhoGEF and PH domain containing 4	393	0.86
chr7_136555280_136555665	0.13	CHRM2	cholinergic receptor, muscarinic 2	1603	0.4
chr5_82768204_82768925	0.13	VCAN	versican	820	0.75
chr6_139014672_139015008	0.13	RP11-390P2.4		616	0.63
chr7_101460813_101461304	0.13	CUX1	cut-like homeobox 1	138	0.97
chr2_26785075_26785548	0.12	C2orf70	chromosome 2 open reading frame 70	139	0.96
chr2_28601499_28601815	0.12	FOSL2	FOS-like antigen 2	14012	0.17
chr15_31631055_31631206	0.12	KLF13	Kruppel-like factor 13	1006	0.69
chr1_12656148_12656570	0.12	DHRS3	dehydrogenase/reductase (SDR family) member 3	38	0.98
chr1_240161229_240161618	0.12	FMN2	formin 2	16225	0.27
chr6_10418997_10419238	0.12	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	754	0.63
chr15_25199832_25199983	0.12	SNRPN	small nuclear ribonucleoprotein polypeptide N	167	0.55
chr5_139050794_139051015	0.12	CXXC5	CXXC finger protein 5	4117	0.25
chr16_1458660_1458855	0.12	LA16c-312E8.2		78	0.93
chr11_111794191_111794413	0.12	CRYAB	crystallin, alpha B	144	0.91
chr17_76879212_76879961	0.12	TIMP2	TIMP metallopeptidase inhibitor 2	9354	0.14
chr9_139429643_139429794	0.12	RP11-413M3.4		7615	0.1
chr19_10399295_10399446	0.12	CTD-2369P2.8		325	0.66
chr1_1292304_1292633	0.12	MXRA8	matrix-remodelling associated 8	1447	0.18
chr11_1329925_1330473	0.12	TOLLIP	toll interacting protein	650	0.47
chr1_208137449_208137600	0.12	CD34	CD34 molecule	52777	0.17
chr19_1154555_1155129	0.12	SBNO2	strawberry notch homolog 2 (Drosophila)	293	0.85
chr6_85472288_85472456	0.12	TBX18	T-box 18	701	0.8
chr5_14204410_14204680	0.12	TRIO	trio Rho guanine nucleotide exchange factor	20638	0.29
chr7_30028817_30029270	0.12	SCRN1	secernin 1	285	0.79
chr11_75210907_75211158	0.11	RP11-939C17.4		8404	0.15
chr9_72658914_72659269	0.11	MAMDC2	MAM domain containing 2	594	0.81
chr10_29922441_29923089	0.11	SVIL	supervillin	1136	0.54
chr11_503866_504897	0.11	RNH1	ribonuclease/angiogenin inhibitor 1	171	0.89
chrX_51239510_51239840	0.11	NUDT11	nudix (nucleoside diphosphate linked moiety X)-type motif 11	227	0.96
chr7_64700247_64700513	0.11	ENSG00000265175	.	27929	0.19
chr12_112560647_112560960	0.11	TRAFD1	TRAF-type zinc finger domain containing 1	2502	0.22
chr10_104359700_104359851	0.11	ENSG00000207029	.	8494	0.17
chr1_227506323_227506932	0.11	CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	452	0.9
chr17_77756152_77756303	0.11	CBX2	chromobox homolog 2	4234	0.16
chr12_105477204_105477480	0.11	ALDH1L2	aldehyde dehydrogenase 1 family, member L2	999	0.49
chr4_177712658_177713139	0.11	VEGFC	vascular endothelial growth factor C	983	0.71
chr21_45553858_45554178	0.11	C21orf33	chromosome 21 open reading frame 33	322	0.87
chr17_39970124_39970275	0.11	FKBP10	FK506 binding protein 10, 65 kDa	1016	0.29
chr7_5467738_5468320	0.11	TNRC18	trinucleotide repeat containing 18	2984	0.19
chr4_8272289_8272466	0.11	HTRA3	HtrA serine peptidase 3	873	0.65
chr11_14403032_14403213	0.11	RRAS2	related RAS viral (r-ras) oncogene homolog 2	17070	0.25
chr6_21665058_21665374	0.11	SOX4	SRY (sex determining region Y)-box 4	71145	0.14
chr14_103058041_103058305	0.11	RCOR1	REST corepressor 1	825	0.6
chr3_46972745_46972896	0.11	PTH1R	parathyroid hormone 1 receptor	28731	0.12
chr7_27191813_27192140	0.11	HOXA-AS3	HOXA cluster antisense RNA 3	2305	0.1
chr20_4878730_4878881	0.11	SLC23A2	solute carrier family 23 (ascorbic acid transporter), member 2	1488	0.39
chr17_15850937_15851088	0.11	ADORA2B	adenosine A2b receptor	2781	0.26
chr3_32001454_32001950	0.11	OSBPL10	oxysterol binding protein-like 10	21090	0.19
chr17_15870184_15870534	0.11	ADORA2B	adenosine A2b receptor	22128	0.14
chr6_143014333_143014633	0.11	RP1-67K17.3		55097	0.17
chr8_18942225_18942376	0.11	PSD3	pleckstrin and Sec7 domain containing 3	60	0.99
chr7_28724839_28725039	0.11	CREB5	cAMP responsive element binding protein 5	659	0.83
chr1_206255126_206255277	0.11	ENSG00000252692	.	5892	0.18
chr18_67069113_67069341	0.11	DOK6	docking protein 6	936	0.74
chr9_38067740_38068285	0.11	SHB	Src homology 2 domain containing adaptor protein B	1196	0.58
chr2_238813531_238813682	0.11	ENSG00000263723	.	35059	0.15
chr17_12877207_12877393	0.11	ENSG00000266152	.	1158	0.45
chrX_129657730_129658601	0.11	RBMX2	RNA binding motif protein, X-linked 2	122186	0.05
chr2_120189452_120190154	0.11	TMEM37	transmembrane protein 37	358	0.88
chr10_49678072_49678223	0.11	ARHGAP22	Rho GTPase activating protein 22	18477	0.21
chr5_129240122_129240866	0.10	CHSY3	chondroitin sulfate synthase 3	329	0.79
chr9_130659943_130660240	0.10	ST6GALNAC6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	200	0.87
chr19_13392901_13393052	0.10	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	6266	0.22
chr5_150863261_150863412	0.10	ENSG00000200227	.	6198	0.17
chr11_17096518_17096669	0.10	ENSG00000272034	.	302	0.67
chr1_208133085_208133236	0.10	CD34	CD34 molecule	48413	0.18
chr17_45277656_45277848	0.10	MYL4	myosin, light chain 4, alkali; atrial, embryonic	8649	0.12
chr8_104152453_104152604	0.10	BAALC	brain and acute leukemia, cytoplasmic	410	0.69
chr17_79859390_79859541	0.10	NPB	neuropeptide B	520	0.48
chr4_75480156_75480665	0.10	AREGB	amphiregulin B	219	0.94
chr6_166074004_166074283	0.10	PDE10A	phosphodiesterase 10A	1414	0.55
chr15_81072509_81072719	0.10	KIAA1199	KIAA1199	902	0.65
chr11_61595808_61596402	0.10	FADS2	fatty acid desaturase 2	353	0.64
chr1_119521934_119522435	0.10	TBX15	T-box 15	8244	0.28
chr17_2613659_2614081	0.10	CLUH	clustered mitochondria (cluA/CLU1) homolog	622	0.56
chr9_90131995_90132200	0.10	DAPK1	death-associated protein kinase 1	18177	0.23
chr9_130308551_130308785	0.10	FAM129B	family with sequence similarity 129, member B	22699	0.15
chr10_95225832_95226004	0.10	MYOF	myoferlin	16033	0.19
chr1_16087111_16087637	0.10	FBLIM1	filamin binding LIM protein 1	2082	0.2
chr4_75310406_75310883	0.10	AREG	amphiregulin	207	0.94
chr4_90757689_90758348	0.10	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	109	0.84
chr10_99344095_99344388	0.10	PI4K2A	Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein	110	0.53
chr19_47991140_47991431	0.10	NAPA-AS1	NAPA antisense RNA 1	3720	0.15
chr3_38325709_38325860	0.10	SLC22A14	solute carrier family 22, member 14	1995	0.29
chr3_184286341_184286629	0.10	EPHB3	EPH receptor B3	6913	0.2
chr16_2204070_2204407	0.10	ENSG00000206630	.	868	0.23
chr4_7907648_7907905	0.10	AC097381.1		32952	0.16
chr22_20790240_20790391	0.10	SCARF2	scavenger receptor class F, member 2	1797	0.22
chr2_132430511_132430704	0.10	C2orf27A	chromosome 2 open reading frame 27A	49341	0.15
chr9_130640034_130640202	0.10	AK1	adenylate kinase 1	96	0.92
chr19_13734648_13734872	0.10	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	44	0.98
chr5_52105955_52106201	0.10	CTD-2288O8.1		22218	0.18
chr1_84158363_84158987	0.10	ENSG00000223231	.	100885	0.09
chr1_157963513_157964097	0.09	KIRREL	kin of IRRE like (Drosophila)	370	0.89
chr6_158478262_158478415	0.09	SYNJ2	synaptojanin 2	20374	0.19
chr12_49183193_49183344	0.09	ADCY6	adenylate cyclase 6	448	0.69
chr4_170192362_170192994	0.09	SH3RF1	SH3 domain containing ring finger 1	422	0.9
chr7_11579827_11580194	0.09	AC004160.4		133428	0.05
chr10_79470838_79471281	0.09	ENSG00000199664	.	65754	0.1
chr5_79866210_79866442	0.09	ANKRD34B	ankyrin repeat domain 34B	19	0.98
chr9_137236302_137236526	0.09	RXRA	retinoid X receptor, alpha	17988	0.22
chr10_43573048_43573466	0.09	RET	ret proto-oncogene	730	0.74
chr20_50417404_50418104	0.09	SALL4	spalt-like transcription factor 4	1193	0.55
chr19_47522872_47523023	0.09	NPAS1	neuronal PAS domain protein 1	130	0.96
chr19_18521360_18521522	0.09	ENSG00000221167	.	849	0.39
chr13_110959773_110960124	0.09	COL4A2	collagen, type IV, alpha 2	334	0.6
chr13_44730017_44730207	0.09	SMIM2-IT1	SMIM2 intronic transcript 1 (non-protein coding)	2246	0.3
chr1_1291746_1291897	0.09	MXRA8	matrix-remodelling associated 8	2094	0.12
chr2_10540557_10540762	0.09	HPCAL1	hippocalcin-like 1	19488	0.18
chr8_687260_687856	0.09	ERICH1-AS1	ERICH1 antisense RNA 1	93	0.97
chr19_45146992_45147170	0.09	PVR	poliovirus receptor	17	0.97
chr17_76921771_76922019	0.09	TIMP2	TIMP metallopeptidase inhibitor 2	426	0.79

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0071605	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.3	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0030813	positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of nucleoside metabolic process(GO:0045979) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) positive regulation of ATP metabolic process(GO:1903580)
0.0	0.1	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.2	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0001573	ganglioside metabolic process(GO:0001573)
0.0	0.2	GO:0002070	epithelial cell maturation(GO:0002070)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0002674	negative regulation of acute inflammatory response(GO:0002674)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.1	GO:0002551	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0001554	luteolysis(GO:0001554)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0048293	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:0002678	positive regulation of chronic inflammatory response(GO:0002678)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0033088	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.0	GO:0006172	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.3	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.0	GO:0019322	pentose biosynthetic process(GO:0019322)
0.0	0.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:1903960	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.0	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.1	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	GO:0043083	synaptic cleft(GO:0043083)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0071437	invadopodium(GO:0071437)
0.3	GO:0001533	cornified envelope(GO:0001533)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1	GO:0031143	pseudopodium(GO:0031143)
0.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.3	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.0	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.6	GO:0008009	chemokine activity(GO:0008009)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.4	PID IL23 PATHWAY	IL23-mediated signaling events
0.5	PID ILK PATHWAY	Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines