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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF691

Z-value: 1.14

Motif logo

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Transcription factors associated with ZNF691

Gene Symbol Gene ID Gene Info
ZNF691
ENSG00000164011.13 ZNF691

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
ZNF691chr1_43316561_433167122780.868747-0.761.7e-02Click!
ZNF691chr1_43314081_433142328060.4932290.541.4e-01Click!
ZNF691chr1_43312221_433129902970.6468670.039.3e-01Click!

Activity of the ZNF691 motif across conditions

Conditions sorted by the z-value of the ZNF691 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr22_50523508_50523892 0.74 MLC1
 megalencephalic leukoencephalopathy with subcortical cysts 1
 12
 0.97
chr3_56950582_56950733 0.71 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 158
 0.97
chr10_9058777_9059039 0.70 ENSG00000212505
 .
 360114
 0.01
chr14_22971510_22971661 0.60 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 15414
 0.1
chr14_23000842_23001170 0.58 TRAJ15
 T cell receptor alpha joining 15
 2426
 0.17
chr12_5996777_5996928 0.55 ANO2
 anoctamin 2
 58546
 0.15
chr4_108971019_108971228 0.53 HADH
 hydroxyacyl-CoA dehydrogenase
 45332
 0.15
chr6_33044279_33044526 0.52 HLA-DPB1
 major histocompatibility complex, class II, DP beta 1
 659
 0.57
chr3_196367146_196367308 0.51 PIGX
 phosphatidylinositol glycan anchor biosynthesis, class X
 581
 0.45
chr1_111739082_111739233 0.50 DENND2D
 DENN/MADD domain containing 2D
 4154
 0.14
chr15_81592474_81592729 0.50 IL16
 interleukin 16
 844
 0.63
chr3_112216938_112217091 0.50 BTLA
 B and T lymphocyte associated
 1191
 0.55
chr13_24826937_24827088 0.49 SPATA13
 spermatogenesis associated 13
 1156
 0.4
chr1_198628489_198628711 0.48 RP11-553K8.5
7590
 0.25
chr1_111213979_111214130 0.47 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 3601
 0.23
chr7_142494445_142494858 0.47 PRSS3P2
 protease, serine, 3 pseudogene 2
 13520
 0.18
chr14_22539203_22539554 0.47 ENSG00000238634
 .
 71509
 0.12
chr3_156192769_156192920 0.46 KCNAB1-AS1
 KCNAB1 antisense RNA 1
 28150
 0.2
chr13_30948639_30948822 0.44 KATNAL1
 katanin p60 subunit A-like 1
 67109
 0.12
chr14_102293036_102293187 0.44 CTD-2017C7.1
12757
 0.15
chr19_18230369_18230520 0.44 IL12RB1
 interleukin 12 receptor, beta 1
 20690
 0.1
chr3_186743992_186744192 0.43 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 821
 0.7
chr2_74518166_74518317 0.43 SLC4A5
 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
 409
 0.81
chr1_226067206_226067421 0.43 TMEM63A
 transmembrane protein 63A
 1934
 0.23
chr5_133455627_133455909 0.43 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 3541
 0.27
chr19_51873675_51874043 0.43 CLDND2
 claudin domain containing 2
 1602
 0.15
chr14_22970808_22971009 0.42 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 14737
 0.1
chr6_112078365_112078719 0.41 FYN
 FYN oncogene related to SRC, FGR, YES
 1775
 0.47
chr10_72192454_72192856 0.41 AC022532.1
 Uncharacterized protein
 1930
 0.29
chr11_65321714_65321865 0.40 LTBP3
 latent transforming growth factor beta binding protein 3
 591
 0.53
chr2_175456506_175456946 0.40 WIPF1
 WAS/WASL interacting protein family, member 1
 5767
 0.19
chr6_170405095_170405246 0.40 RP11-302L19.1
72571
 0.11
chr13_34184837_34185306 0.40 RFC3
 replication factor C (activator 1) 3, 38kDa
 207115
 0.02
chr8_134069456_134069607 0.39 SLA
 Src-like-adaptor
 3072
 0.32
chr22_23799075_23799226 0.39 ZDHHC8P1
 zinc finger, DHHC-type containing 8 pseudogene 1
 54806
 0.11
chr13_41553204_41553401 0.39 ELF1
 E74-like factor 1 (ets domain transcription factor)
 3116
 0.27
chr6_35016533_35016804 0.38 TCP11
 t-complex 11, testis-specific
 72154
 0.1
chr6_41048535_41048765 0.38 NFYA
 nuclear transcription factor Y, alpha
 7928
 0.13
chr3_56950038_56950370 0.38 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 295
 0.93
chr6_108144289_108144729 0.37 SCML4
 sex comb on midleg-like 4 (Drosophila)
 1007
 0.66
chr14_22947996_22948147 0.37 ENSG00000251002
 .
 2207
 0.16
chr2_223290336_223290619 0.37 SGPP2
 sphingosine-1-phosphate phosphatase 2
 1241
 0.5
chr12_9911079_9911493 0.36 CD69
 CD69 molecule
 2211
 0.26
chr18_13216452_13216669 0.36 RP11-794M8.1
194
 0.92
chr6_139467434_139467700 0.36 HECA
 headcase homolog (Drosophila)
 11318
 0.25
chr11_65883776_65883927 0.36 PACS1
 phosphofurin acidic cluster sorting protein 1
 15617
 0.11
chr14_23007518_23007669 0.36 TRAJ15
 T cell receptor alpha joining 15
 9013
 0.11
chr2_204733780_204733985 0.36 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
 1073
 0.62
chr13_74706686_74707383 0.36 KLF12
 Kruppel-like factor 12
 1360
 0.61
chr22_42177525_42177912 0.36 MEI1
 meiosis inhibitor 1
 21
 0.96
chr14_22772288_22772466 0.36 ENSG00000251002
 .
 129342
 0.04
chr13_100309364_100309515 0.36 ENSG00000263615
 .
 14126
 0.18
chr17_29135904_29136074 0.35 CRLF3
 cytokine receptor-like factor 3
 15700
 0.12
chr20_39769151_39769427 0.35 RP1-1J6.2
2646
 0.27
chr16_27241764_27241915 0.35 NSMCE1
 non-SMC element 1 homolog (S. cerevisiae)
 2560
 0.25
chr2_46578889_46579334 0.35 EPAS1
 endothelial PAS domain protein 1
 54570
 0.13
chr12_51716594_51716774 0.35 BIN2
 bridging integrator 2
 1215
 0.42
chr18_60823743_60823894 0.35 RP11-299P2.1
5265
 0.26
chr10_98134778_98135198 0.34 OPALIN
 oligodendrocytic myelin paranodal and inner loop protein
 15896
 0.21
chr2_10522774_10523051 0.34 HPCAL1
 hippocalcin-like 1
 37235
 0.15
chr17_41738444_41738624 0.33 MEOX1
 mesenchyme homeobox 1
 397
 0.85
chr7_7960072_7960471 0.33 ENSG00000201747
 .
 14121
 0.18
chr9_116911638_116911789 0.33 COL27A1
 collagen, type XXVII, alpha 1
 6127
 0.23
chr2_68961577_68961872 0.33 ARHGAP25
 Rho GTPase activating protein 25
 189
 0.96
chr7_21395262_21395449 0.33 ENSG00000195024
 .
 25626
 0.21
chr12_55378635_55378823 0.32 TESPA1
 thymocyte expressed, positive selection associated 1
 199
 0.95
chr12_92933741_92933892 0.32 ENSG00000238865
 .
 4947
 0.3
chr16_88522781_88522932 0.32 ZFPM1
 zinc finger protein, FOG family member 1
 3131
 0.22
chr15_26104694_26104860 0.32 ATP10A
 ATPase, class V, type 10A
 3578
 0.24
chr6_62995563_62995714 0.32 KHDRBS2
 KH domain containing, RNA binding, signal transduction associated 2
 494
 0.9
chr11_65647291_65647461 0.31 CTSW
 cathepsin W
 47
 0.93
chr18_8441840_8441991 0.31 ENSG00000242985
 .
 29914
 0.14
chr2_135464562_135464727 0.31 TMEM163
 transmembrane protein 163
 11926
 0.28
chr15_40600356_40600529 0.31 PLCB2
 phospholipase C, beta 2
 319
 0.77
chr9_130740055_130740787 0.31 FAM102A
 family with sequence similarity 102, member A
 2371
 0.18
chr17_48047829_48047980 0.31 DLX4
 distal-less homeobox 4
 1210
 0.4
chr13_40397646_40397797 0.31 ENSG00000212553
 .
 33643
 0.19
chr8_111604369_111604520 0.31 KCNV1
 potassium channel, subfamily V, member 1
 616368
 0.0
chr22_36425686_36425854 0.31 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 1297
 0.58
chr5_179235168_179235459 0.31 MGAT4B
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
 1379
 0.24
chr22_27843716_27843867 0.31 RP11-375H17.1
268677
 0.02
chr2_33432670_33432821 0.31 LTBP1
 latent transforming growth factor beta binding protein 1
 35984
 0.2
chr20_44834342_44834493 0.31 CDH22
 cadherin 22, type 2
 45917
 0.14
chr10_9271793_9271944 0.30 ENSG00000212505
 .
 573074
 0.0
chr8_82044855_82045010 0.30 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 20629
 0.26
chr13_100072782_100072933 0.30 ENSG00000266207
 .
 32866
 0.16
chr12_739807_740337 0.30 RP11-218M22.1
15
 0.97
chr3_50487862_50488065 0.30 ENSG00000202322
 .
 30751
 0.11
chr5_133772510_133772733 0.30 CDKN2AIPNL
 CDKN2A interacting protein N-terminal like
 25032
 0.14
chr3_60061066_60061217 0.29 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 103558
 0.09
chrX_12992472_12992678 0.29 TMSB4X
 thymosin beta 4, X-linked
 652
 0.76
chr2_231523885_231524103 0.29 CAB39
 calcium binding protein 39
 53566
 0.12
chr2_43229390_43229541 0.29 ENSG00000207087
 .
 89167
 0.09
chr1_167598231_167598382 0.29 RCSD1
 RCSD domain containing 1
 1024
 0.47
chr5_169729941_169730225 0.29 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 4852
 0.25
chr1_40500456_40500611 0.29 CAP1
 CAP, adenylate cyclase-associated protein 1 (yeast)
 5372
 0.21
chr9_100667248_100667478 0.28 C9orf156
 chromosome 9 open reading frame 156
 7390
 0.17
chr9_136003459_136003610 0.28 RALGDS
 ral guanine nucleotide dissociation stimulator
 1254
 0.38
chr20_4794500_4794911 0.28 RASSF2
 Ras association (RalGDS/AF-6) domain family member 2
 1064
 0.55
chr20_57721382_57721625 0.28 ZNF831
 zinc finger protein 831
 44572
 0.15
chr21_32534825_32534976 0.28 TIAM1
 T-cell lymphoma invasion and metastasis 1
 32361
 0.22
chr2_10472002_10472153 0.28 HPCAL1
 hippocalcin-like 1
 28251
 0.15
chr12_42863299_42863450 0.28 RP11-328C8.4
10206
 0.15
chr10_90911880_90912031 0.27 CH25H
 cholesterol 25-hydroxylase
 55116
 0.1
chr17_4618141_4618477 0.27 ARRB2
 arrestin, beta 2
 575
 0.53
chrX_18359237_18359476 0.27 SCML2
 sex comb on midleg-like 2 (Drosophila)
 13491
 0.24
chr11_128344340_128344491 0.27 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 30874
 0.21
chr12_56881156_56881307 0.27 GLS2
 glutaminase 2 (liver, mitochondrial)
 671
 0.58
chr15_85711869_85712366 0.27 CSPG4P12
 chondroitin sulfate proteoglycan 4 pseudogene 12
 22552
 0.15
chr16_68114330_68114481 0.27 NFATC3
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
 4842
 0.12
chrX_107068956_107069440 0.27 MID2
 midline 2
 89
 0.97
chr1_150536239_150536708 0.27 ADAMTSL4-AS1
 ADAMTSL4 antisense RNA 1
 2504
 0.12
chr11_104914233_104914622 0.27 CARD16
 caspase recruitment domain family, member 16
 1607
 0.35
chr18_75362846_75362997 0.27 ENSG00000252260
 .
 212602
 0.02
chr3_113954111_113954262 0.27 ZNF80
 zinc finger protein 80
 2239
 0.27
chr8_134511475_134511742 0.26 ST3GAL1
 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
 4
 0.99
chr18_74766190_74766781 0.26 MBP
 myelin basic protein
 36751
 0.2
chr6_166747013_166747164 0.26 SFT2D1
 SFT2 domain containing 1
 8991
 0.19
chr18_2636542_2636784 0.26 ENSG00000200875
 .
 13203
 0.14
chr3_45732221_45732372 0.26 SACM1L
 SAC1 suppressor of actin mutations 1-like (yeast)
 1345
 0.36
chrX_153166301_153166452 0.26 AVPR2
 arginine vasopressin receptor 2
 3813
 0.11
chrX_74742629_74743232 0.26 ZDHHC15
 zinc finger, DHHC-type containing 15
 57
 0.99
chr22_50318944_50319095 0.26 CRELD2
 cysteine-rich with EGF-like domains 2
 6638
 0.17
chr12_47605032_47605192 0.26 PCED1B
 PC-esterase domain containing 1B
 4940
 0.24
chr4_187407754_187407905 0.26 F11-AS1
 F11 antisense RNA 1
 14322
 0.19
chr19_10304500_10305008 0.26 DNMT1
 DNA (cytosine-5-)-methyltransferase 1
 548
 0.62
chr6_119027020_119027704 0.26 CEP85L
 centrosomal protein 85kDa-like
 3869
 0.35
chr3_9993293_9993483 0.26 PRRT3
 proline-rich transmembrane protein 3
 686
 0.44
chrX_68310760_68310911 0.25 PJA1
 praja ring finger 1, E3 ubiquitin protein ligase
 71702
 0.13
chr16_29626573_29626859 0.25 ENSG00000266758
 .
 16130
 0.13
chr22_39854364_39854515 0.25 MGAT3
 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
 1090
 0.44
chr15_60771714_60772006 0.25 RP11-219B17.1
441
 0.52
chr10_88299439_88299590 0.25 RP11-77P6.2
17812
 0.18
chr17_56412846_56413076 0.25 ENSG00000264399
 .
 422
 0.69
chr6_32912081_32912232 0.25 HLA-DMB
 major histocompatibility complex, class II, DM beta
 3309
 0.12
chr3_186237256_186237407 0.25 CRYGS
 crystallin, gamma S
 24909
 0.16
chr5_79547739_79547890 0.25 SERINC5
 serine incorporator 5
 4024
 0.22
chr20_35258352_35258894 0.25 SLA2
 Src-like-adaptor 2
 15661
 0.12
chr15_63894184_63894335 0.25 USP3-AS1
 USP3 antisense RNA 1
 471
 0.81
chr4_38511545_38511706 0.25 RP11-617D20.1
114571
 0.06
chr9_20398478_20398629 0.24 ENSG00000263790
 .
 12683
 0.18
chr14_99723060_99723211 0.24 AL109767.1
6150
 0.23
chr13_25172075_25172226 0.24 ENSG00000211508
 .
 11067
 0.18
chr17_32576011_32576162 0.24 CCL2
 chemokine (C-C motif) ligand 2
 6218
 0.14
chr1_53103098_53103249 0.24 FAM159A
 family with sequence similarity 159, member A
 4157
 0.21
chr13_31481253_31481536 0.24 MEDAG
 mesenteric estrogen-dependent adipogenesis
 551
 0.78
chr4_150608043_150608194 0.24 ENSG00000202331
 .
 220594
 0.02
chr13_49875518_49875737 0.24 CAB39L
 calcium binding protein 39-like
 49636
 0.13
chr11_44748940_44749566 0.24 TSPAN18
 tetraspanin 18
 529
 0.86
chr4_143328016_143328342 0.23 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 24233
 0.29
chr9_130212354_130212505 0.23 RPL12
 ribosomal protein L12
 1223
 0.25
chr7_115116722_115116873 0.23 ENSG00000202377
 .
 104699
 0.08
chr12_120689652_120689816 0.23 PXN
 paxillin
 1770
 0.24
chr3_14467300_14467558 0.23 SLC6A6
 solute carrier family 6 (neurotransmitter transporter), member 6
 6749
 0.24
chr14_103541034_103541185 0.23 CDC42BPB
 CDC42 binding protein kinase beta (DMPK-like)
 17310
 0.15
chr9_130539046_130539317 0.23 SH2D3C
 SH2 domain containing 3C
 1839
 0.17
chr1_116694143_116694294 0.23 MAB21L3
 mab-21-like 3 (C. elegans)
 39842
 0.18
chr14_57283183_57283334 0.23 OTX2-AS1
 OTX2 antisense RNA 1 (head to head)
 3249
 0.2
chr7_100224057_100224300 0.23 TFR2
 transferrin receptor 2
 6549
 0.09
chr10_6088158_6088309 0.23 IL2RA
 interleukin 2 receptor, alpha
 16020
 0.13
chr3_106580754_106580905 0.23 ENSG00000252626
 .
 145586
 0.05
chr2_196977844_196978082 0.23 RP11-347P5.1
38024
 0.15
chr12_113416849_113417235 0.23 OAS2
 2'-5'-oligoadenylate synthetase 2, 69/71kDa
 697
 0.66
chr15_78339087_78339263 0.23 ENSG00000221476
 .
 8302
 0.14
chrX_55545684_55545835 0.22 USP51
 ubiquitin specific peptidase 51
 30124
 0.17
chr4_2486639_2486842 0.22 RNF4
 ring finger protein 4
 4798
 0.2
chr12_55385441_55385592 0.22 TESPA1
 thymocyte expressed, positive selection associated 1
 6986
 0.23
chr2_68962051_68962936 0.22 ARHGAP25
 Rho GTPase activating protein 25
 479
 0.86
chrX_47508576_47509160 0.22 ELK1
 ELK1, member of ETS oncogene family
 1019
 0.41
chr1_25800454_25800605 0.22 TMEM57
 transmembrane protein 57
 43118
 0.11
chr4_29508375_29508526 0.22 ENSG00000252303
 .
 3807
 0.39
chr19_17516946_17517123 0.22 MVB12A
 multivesicular body subunit 12A
 80
 0.86
chr16_58534963_58535658 0.22 NDRG4
 NDRG family member 4
 62
 0.96
chrX_135056749_135057023 0.22 MMGT1
 membrane magnesium transporter 1
 664
 0.7
chr1_235097634_235097790 0.22 ENSG00000239690
 .
 57779
 0.14
chr5_1313580_1313801 0.22 ENSG00000263670
 .
 4198
 0.2
chr10_49731081_49731274 0.22 ARHGAP22
 Rho GTPase activating protein 22
 1104
 0.56
chr7_36817405_36817556 0.22 AOAH
 acyloxyacyl hydrolase (neutrophil)
 53326
 0.14
chr3_186490709_186491008 0.22 ENSG00000207505
 .
 1122
 0.25
chr2_30726606_30726757 0.22 LCLAT1
 lysocardiolipin acyltransferase 1
 56412
 0.15
chr11_58903611_58903772 0.22 FAM111A
 family with sequence similarity 111, member A
 6530
 0.18
chr19_36036123_36036368 0.22 AD000090.2
149
 0.62
chr7_151078177_151078328 0.22 NUB1
 negative regulator of ubiquitin-like proteins 1
 12336
 0.13
chr1_44870677_44871051 0.22 RNF220
 ring finger protein 220
 2
 0.98
chr3_186748872_186749023 0.22 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 5676
 0.26
chr11_118311027_118311308 0.22 KMT2A
 lysine (K)-specific methyltransferase 2A
 3690
 0.13
chr18_77492609_77492760 0.22 RP11-567M16.5
29033
 0.2
chr5_10632325_10632658 0.22 ANKRD33B-AS1
 ANKRD33B antisense RNA 1
 4154
 0.28
chr8_69687686_69687837 0.21 ENSG00000239184
 .
 79883
 0.12
chr1_206675169_206675320 0.21 RP11-534L20.5
2037
 0.24
chr7_84569129_84569450 0.21 SEMA3D
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
 181962
 0.03
chr20_30432784_30432935 0.21 FOXS1
 forkhead box S1
 561
 0.67
chr17_46060430_46060581 0.21 CDK5RAP3
 CDK5 regulatory subunit associated protein 3
 6417
 0.1
chr20_17945955_17946160 0.21 ENSG00000212232
 .
 2468
 0.21
chr19_30158859_30159039 0.21 PLEKHF1
 pleckstrin homology domain containing, family F (with FYVE domain) member 1
 1168
 0.55
chr2_158289727_158289878 0.21 CYTIP
 cytohesin 1 interacting protein
 6124
 0.23
chr11_122597673_122598179 0.21 ENSG00000239079
 .
 907
 0.67
chr22_48494042_48494263 0.21 ENSG00000266508
 .
 176024
 0.04
chr6_130846468_130846619 0.21 ENSG00000202438
 .
 48714
 0.16
chr6_166649375_166649526 0.21 ENSG00000201292
 .
 26559
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of ZNF691

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1900121 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1 0.3 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.3 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.2 GO:0001757 somite specification(GO:0001757)
0.1 0.2 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.2 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.3 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.1 0.2 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.1 0.2 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.2 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.2 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.2 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.2 GO:0045329 amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.2 GO:0007063 regulation of sister chromatid cohesion(GO:0007063)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.3 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.5 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 0.1 GO:0002664 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0 0.2 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.0 GO:0060430 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.1 GO:0009151 purine deoxyribonucleotide metabolic process(GO:0009151)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.5 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0 0.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0 0.2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0032048 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0040009 regulation of growth rate(GO:0040009)
0.0 0.2 GO:0034405 response to fluid shear stress(GO:0034405)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0072577 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.0 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.0 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.0 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.0 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.0 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0 0.1 GO:0048343 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.1 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.0 GO:0090205 positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.2 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.1 GO:0016556 mRNA modification(GO:0016556)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.1 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.0 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.1 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.1 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.0 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.0 GO:0034776 response to histamine(GO:0034776)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.0 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.0 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.0 GO:0010586 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.3 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.3 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.0 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.4 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.0 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.0 GO:0048302 regulation of isotype switching to IgG isotypes(GO:0048302)
0.0 0.0 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.0 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.0 GO:0051657 maintenance of organelle location(GO:0051657)
0.0 0.2 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.1 GO:1902603 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0 0.0 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.0 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0003254 regulation of membrane depolarization(GO:0003254) regulation of mitochondrial depolarization(GO:0051900)
0.0 0.0 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 0.2 GO:0006541 glutamine metabolic process(GO:0006541)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.3 GO:0022616 DNA strand elongation(GO:0022616)
0.0 0.1 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.0 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0008278 cohesin complex(GO:0008278)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.4 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0016011 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.0 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.0 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.4 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004)
0.0 0.2 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.0 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0048256 flap endonuclease activity(GO:0048256)
0.0 0.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0005283 sodium:amino acid symporter activity(GO:0005283)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.3 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.0 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.0 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.0 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins