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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF740_ZNF219

Z-value: 1.09

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Transcription factors associated with ZNF740_ZNF219

Gene Symbol	Gene ID	Gene Info
ZNF740 Ensembl NCBI GeneCards UniProt	ENSG00000139651.9	ZNF740
ZNF219 Ensembl NCBI GeneCards UniProt	ENSG00000165804.11	ZNF219

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF219	chr14_21554121_21554272	7791	0.090077	0.72	3.0e-02	Click!
ZNF219	chr14_21571987_21572281	396	0.720913	0.66	5.5e-02	Click!
ZNF219	chr14_21566135_21566286	589	0.460361	0.62	7.4e-02	Click!
ZNF219	chr14_21572301_21572831	315	0.792366	0.62	7.5e-02	Click!
ZNF219	chr14_21556081_21556232	5831	0.096321	0.53	1.4e-01	Click!
ZNF740	chr12_53574456_53574687	87	0.539000	0.59	9.5e-02	Click!

Activity of the ZNF740_ZNF219 motif across conditions

Conditions sorted by the z-value of the ZNF740_ZNF219 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_10341979_10342223	0.68	DNMT1	DNA (cytosine-5-)-methyltransferase 1	139	0.49
chr11_47421960_47422248	0.67	ENSG00000264583	.	417	0.68
chr17_80176095_80176246	0.59	RP13-516M14.2		4067	0.12
chr22_44577376_44577610	0.54	PARVG	parvin, gamma	215	0.96
chr17_72743404_72743555	0.46	ENSG00000264624	.	1273	0.21
chr12_54694539_54694712	0.45	NFE2	nuclear factor, erythroid 2	174	0.67
chr7_139761785_139761951	0.39	PARP12	poly (ADP-ribose) polymerase family, member 12	1653	0.43
chr19_912362_912526	0.37	R3HDM4	R3H domain containing 4	787	0.39
chr17_61773603_61773754	0.37	LIMD2	LIM domain containing 2	2844	0.21
chr17_38478045_38478318	0.36	RARA	retinoic acid receptor, alpha	3644	0.15
chr17_43300272_43300459	0.36	CTD-2020K17.1		776	0.38
chr1_150540056_150540997	0.34	ENSG00000264508	.	1190	0.22
chr9_69785762_69786779	0.34	IGKV1OR-2	immunoglobulin kappa variable 1/OR-2 (pseudogene)	8317	0.25
chrX_40014744_40014994	0.33	BCOR	BCL6 corepressor	8987	0.31
chr7_97910621_97910821	0.31	BRI3	brain protein I3	258	0.91
chr1_40157482_40157633	0.30	HPCAL4	hippocalcin like 4	196	0.61
chr3_107243151_107243484	0.30	BBX	bobby sox homolog (Drosophila)	113	0.98
chr16_85647451_85647602	0.30	GSE1	Gse1 coiled-coil protein	568	0.78
chr1_32314203_32314496	0.29	SPOCD1	SPOC domain containing 1	32697	0.13
chr19_14494334_14494521	0.28	CD97	CD97 molecule	2171	0.24
chr15_31656981_31657132	0.28	KLF13	Kruppel-like factor 13	1301	0.61
chrX_48774424_48774575	0.27	PIM2	pim-2 oncogene	1487	0.23
chr14_52779713_52779864	0.27	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	1235	0.57
chr11_129872420_129873004	0.27	PRDM10	PR domain containing 10	13	0.98
chr19_52133397_52133630	0.27	SIGLEC5	sialic acid binding Ig-like lectin 5	75	0.95
chr6_4777132_4777289	0.27	CDYL	chromodomain protein, Y-like	541	0.75
chr19_4543528_4543679	0.26	ENSG00000263974	.	1604	0.21
chr2_157189811_157190046	0.26	NR4A2	nuclear receptor subfamily 4, group A, member 2	696	0.78
chr17_56405619_56405770	0.26	BZRAP1	benzodiazepine receptor (peripheral) associated protein 1	249	0.73
chr7_21467616_21467934	0.26	SP4	Sp4 transcription factor	114	0.97
chr19_1068246_1068401	0.25	HMHA1	histocompatibility (minor) HA-1	826	0.4
chr10_61659826_61659977	0.25	CCDC6	coiled-coil domain containing 6	6513	0.28
chr18_77793817_77793982	0.25	TXNL4A	thioredoxin-like 4A	8	0.89
chr22_20784096_20784540	0.25	SCARF2	scavenger receptor class F, member 2	7794	0.11
chr2_54787203_54787366	0.25	SPTBN1	spectrin, beta, non-erythrocytic 1	1753	0.36
chr21_44204010_44204161	0.25	AP001627.1		42217	0.15
chrX_48542765_48543057	0.24	WAS	Wiskott-Aldrich syndrome	743	0.54
chr17_76128459_76128696	0.24	TMC6	transmembrane channel-like 6	89	0.94
chr12_4383631_4384229	0.24	CCND2-AS2	CCND2 antisense RNA 2	301	0.78
chr11_1875039_1875307	0.24	LSP1	lymphocyte-specific protein 1	973	0.36
chr6_137539516_137539806	0.24	IFNGR1	interferon gamma receptor 1	10	0.99
chr9_136933745_136934121	0.23	BRD3	bromodomain containing 3	276	0.9
chr17_40264582_40264792	0.23	DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	45	0.95
chr1_24969808_24970031	0.23	SRRM1	serine/arginine repetitive matrix 1	129	0.96
chr12_122230893_122231238	0.23	RHOF	ras homolog family member F (in filopodia)	201	0.93
chr2_233925739_233925978	0.23	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	669	0.7
chr5_39201497_39202174	0.22	FYB	FYN binding protein	1294	0.59
chr8_121823290_121823441	0.22	SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	1018	0.42
chr17_66192970_66193249	0.22	LRRC37A16P	leucine rich repeat containing 37, member A16, pseudogene	44500	0.11
chr10_134368672_134368823	0.22	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	17104	0.21
chr18_72922732_72923415	0.22	TSHZ1	teashirt zinc finger homeobox 1	363	0.87
chr12_31882551_31882882	0.22	AMN1	antagonist of mitotic exit network 1 homolog (S. cerevisiae)	608	0.71
chr5_131832293_131832540	0.22	IRF1	interferon regulatory factor 1	5926	0.15
chr7_91569688_91570087	0.22	AKAP9	A kinase (PRKA) anchor protein 9	294	0.94
chr19_4066716_4067152	0.22	ZBTB7A	zinc finger and BTB domain containing 7A	9	0.96
chrX_147691631_147691782	0.21	AFF2-IT1	AFF2 intronic transcript 1 (non-protein coding)	63307	0.14
chr2_43449640_43450246	0.21	ZFP36L2	ZFP36 ring finger protein-like 2	3805	0.27
chr1_236051645_236051799	0.21	LYST	lysosomal trafficking regulator	4850	0.19
chr9_33817406_33817596	0.21	UBE2R2	ubiquitin-conjugating enzyme E2R 2	64	0.94
chrX_2419173_2419324	0.21	DHRSX	dehydrogenase/reductase (SDR family) X-linked	229	0.51
chr11_2326464_2326615	0.21	TSPAN32	tetraspanin 32	2441	0.18
chr6_30798000_30798388	0.21	ENSG00000202241	.	33833	0.07
chrY_2369174_2369325	0.21	ENSG00000251841	.	283541	0.01
chr6_90793980_90794207	0.21	ENSG00000222078	.	82868	0.09
chr12_57870819_57871184	0.21	ARHGAP9	Rho GTPase activating protein 9	566	0.53
chr10_82215935_82216086	0.20	TSPAN14	tetraspanin 14	1899	0.36
chr19_12949779_12950060	0.20	MAST1	microtubule associated serine/threonine kinase 1	571	0.48
chr12_94544055_94544362	0.20	PLXNC1	plexin C1	1709	0.42
chr14_105527834_105528220	0.20	GPR132	G protein-coupled receptor 132	3740	0.23
chrX_131157971_131158122	0.20	MST4	Serine/threonine-protein kinase MST4	410	0.87
chr2_98547935_98548086	0.20	ENSG00000238719	.	18430	0.21
chr11_640222_640373	0.20	DRD4	dopamine receptor D4	3004	0.11
chr14_99735608_99735969	0.20	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	1777	0.38
chr1_27883616_27883836	0.20	RP1-159A19.4		31410	0.13
chr1_156124352_156124692	0.20	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	360	0.78
chr3_43329026_43329294	0.20	SNRK	SNF related kinase	1082	0.53
chr6_1610062_1610262	0.20	FOXC1	forkhead box C1	519	0.87
chr4_38665848_38666421	0.20	RP11-617D20.1		115	0.61
chr7_949432_949583	0.20	ADAP1	ArfGAP with dual PH domains 1	4793	0.16
chr12_51611544_51611860	0.20	POU6F1	POU class 6 homeobox 1	225	0.9
chr18_60987754_60988433	0.20	BCL2	B-cell CLL/lymphoma 2	732	0.64
chr17_29637369_29637894	0.20	EVI2B	ecotropic viral integration site 2B	3471	0.16
chr19_3035801_3036232	0.19	TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	6404	0.13
chr15_69075318_69075469	0.19	ENSG00000265195	.	18871	0.22
chr17_21156722_21156881	0.19	C17orf103	chromosome 17 open reading frame 103	79	0.97
chr19_16774664_16774815	0.19	TMEM38A	transmembrane protein 38A	2667	0.14
chr17_57643262_57643540	0.19	DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40	417	0.85
chr19_6481304_6482171	0.19	DENND1C	DENN/MADD domain containing 1C	27	0.95
chr8_38759681_38760174	0.19	PLEKHA2	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	1065	0.52
chr1_151431863_151432024	0.19	POGZ	pogo transposable element with ZNF domain	2	0.96
chr11_441689_441900	0.19	ANO9	anoctamin 9	217	0.82
chr18_60194123_60194717	0.19	ZCCHC2	zinc finger, CCHC domain containing 2	3568	0.33
chr12_124942372_124942523	0.19	NCOR2	nuclear receptor corepressor 2	25868	0.25
chr17_55334331_55334657	0.19	MSI2	musashi RNA-binding protein 2	115	0.98
chr20_48329140_48329431	0.19	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	1130	0.5
chr1_26646074_26646278	0.19	UBXN11	UBX domain protein 11	1322	0.27
chr7_45067326_45068016	0.18	CCM2	cerebral cavernous malformation 2	400	0.81
chr17_4403063_4403461	0.18	AC118754.4		293	0.8
chr19_42784997_42785148	0.18	CIC	capicua transcriptional repressor	3100	0.12
chr19_47615950_47616307	0.18	SAE1	SUMO1 activating enzyme subunit 1	403	0.69
chr9_140348775_140349192	0.18	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor	39	0.96
chrX_12990058_12990209	0.18	TMSB4X	thymosin beta 4, X-linked	3094	0.3
chr7_158656531_158656832	0.18	WDR60	WD repeat domain 60	5456	0.27
chr13_74708290_74708441	0.18	KLF12	Kruppel-like factor 12	29	0.99
chr15_78361308_78361764	0.18	TBC1D2B	TBC1 domain family, member 2B	3071	0.18
chr15_41219932_41220083	0.18	DLL4	delta-like 4 (Drosophila)	1584	0.27
chr22_39323214_39323365	0.18	APOBEC3A	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A	25467	0.12
chr5_156696225_156696376	0.18	CYFIP2	cytoplasmic FMR1 interacting protein 2	62	0.96
chr15_100106167_100106396	0.18	MEF2A	myocyte enhancer factor 2A	11	0.98
chr17_27139690_27139995	0.17	FAM222B	family with sequence similarity 222, member B	389	0.7
chr1_21659698_21659849	0.17	ECE1	endothelin converting enzyme 1	12224	0.21
chr15_65477311_65477678	0.17	CLPX	caseinolytic mitochondrial matrix peptidase chaperone subunit	186	0.93
chr15_41953518_41954024	0.17	MGA	MGA, MAX dimerization protein	1161	0.47
chr6_30649932_30650278	0.17	PPP1R18	protein phosphatase 1, regulatory subunit 18	4888	0.08
chr14_74551356_74551507	0.17	LIN52	lin-52 homolog (C. elegans)	68	0.72
chr1_27816833_27817254	0.17	WASF2	WAS protein family, member 2	374	0.86
chr9_20622216_20622410	0.17	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	201	0.95
chr16_10710662_10710813	0.17	EMP2	epithelial membrane protein 2	36182	0.13
chr11_2159500_2159786	0.17	IGF2	insulin-like growth factor 2 (somatomedin A)	561	0.59
chr5_88589582_88589733	0.17	MEF2C-AS1	MEF2C antisense RNA 1	124967	0.06
chr9_135114959_135115110	0.17	ENSG00000221105	.	24772	0.21
chr14_90084669_90085459	0.17	FOXN3	forkhead box N3	410	0.78
chr11_108463883_108464034	0.16	EXPH5	exophilin 5	416	0.89
chr17_2717574_2718059	0.16	RAP1GAP2	RAP1 GTPase activating protein 2	18040	0.17
chr2_43451286_43451513	0.16	ZFP36L2	ZFP36 ring finger protein-like 2	2349	0.34
chr19_15574852_15575181	0.16	RASAL3	RAS protein activator like 3	366	0.8
chr19_17958305_17958511	0.16	JAK3	Janus kinase 3	418	0.74
chr2_178129639_178129940	0.16	NFE2L2	nuclear factor, erythroid 2-like 2	70	0.91
chr7_129588935_129590397	0.16	UBE2H	ubiquitin-conjugating enzyme E2H	1501	0.28
chr8_145027093_145027557	0.16	PLEC	plectin	763	0.48
chr10_3822916_3823697	0.16	KLF6	Kruppel-like factor 6	4079	0.25
chr8_144108277_144108585	0.16	LY6E	lymphocyte antigen 6 complex, locus E	8457	0.17
chr8_145639102_145639331	0.16	SLC39A4	solute carrier family 39 (zinc transporter), member 4	2680	0.09
chr21_40759688_40760056	0.16	WRB	tryptophan rich basic protein	181	0.93
chr2_237880489_237880640	0.16	ENSG00000202341	.	43384	0.17
chr14_24780359_24781199	0.16	LTB4R	leukotriene B4 receptor	74	0.58
chr7_50345445_50345596	0.16	IKZF1	IKAROS family zinc finger 1 (Ikaros)	1142	0.64
chr2_85166549_85166831	0.16	KCMF1	potassium channel modulatory factor 1	31526	0.15
chr7_1979405_1979706	0.16	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	630	0.8
chr16_85558650_85558942	0.16	ENSG00000264203	.	83698	0.08
chr10_75633716_75633937	0.16	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	393	0.78
chrX_39956550_39956704	0.16	BCOR	BCL6 corepressor	29	0.99
chr19_912608_912979	0.16	R3HDM4	R3H domain containing 4	438	0.64
chr11_66405551_66405805	0.16	RBM4	RNA binding motif protein 4	410	0.71
chr22_32313508_32313842	0.16	C22orf24	chromosome 22 open reading frame 24	20728	0.14
chr12_122243825_122244586	0.16	SETD1B	SET domain containing 1B	1567	0.32
chr16_85646303_85646802	0.16	GSE1	Gse1 coiled-coil protein	211	0.95
chrY_1522891_1523042	0.16	NA	NA	> 10⁶	NA
chr21_46348074_46348493	0.16	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	350	0.75
chr3_194207533_194207696	0.16	ATP13A3	ATPase type 13A3	226	0.77
chr9_130539046_130539317	0.16	SH2D3C	SH2 domain containing 3C	1839	0.17
chr15_25684395_25684621	0.16	UBE3A	ubiquitin protein ligase E3A	380	0.82
chr10_126849381_126849702	0.16	CTBP2	C-terminal binding protein 2	54	0.99
chr16_3005959_3006166	0.15	LA16c-321D4.2		1785	0.16
chr1_154976315_154976466	0.15	ZBTB7B	zinc finger and BTB domain containing 7B	1095	0.25
chr17_7787815_7787966	0.15	CHD3	chromodomain helicase DNA binding protein 3	234	0.73
chr17_32965108_32965375	0.15	TMEM132E	transmembrane protein 132E	57473	0.13
chr11_71935004_71935259	0.15	INPPL1	inositol polyphosphate phosphatase-like 1	143	0.92
chr8_61591908_61592174	0.15	CHD7	chromodomain helicase DNA binding protein 7	82	0.98
chr19_14887538_14887792	0.15	EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	11	0.97
chr19_6728541_6728856	0.15	C3	complement component 3	1875	0.22
chr4_185188898_185189263	0.15	ENSG00000221523	.	496	0.82
chr14_22958789_22958996	0.15	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	2721	0.15
chr12_6716856_6717254	0.15	CHD4	chromodomain helicase DNA binding protein 4	413	0.67
chr16_85934507_85934793	0.15	IRF8	interferon regulatory factor 8	1645	0.44
chr17_29820809_29821042	0.15	RAB11FIP4	RAB11 family interacting protein 4 (class II)	5799	0.15
chr10_126840512_126840747	0.15	CTBP2	C-terminal binding protein 2	6656	0.3
chr11_119598080_119598587	0.15	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	930	0.54
chrX_70474174_70474507	0.15	ZMYM3	zinc finger, MYM-type 3	49	0.97
chr7_73119920_73120071	0.15	ENSG00000265724	.	5652	0.11
chr20_4804308_4804651	0.15	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	188	0.95
chr1_212781685_212782134	0.15	ATF3	activating transcription factor 3	103	0.96
chr2_214006925_214007076	0.15	IKZF2	IKAROS family zinc finger 2 (Helios)	6353	0.32
chr2_36683900_36684051	0.15	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	56858	0.13
chr18_5295757_5296173	0.15	ZBTB14	zinc finger and BTB domain containing 14	74	0.98
chr19_10704173_10704324	0.15	AP1M2	adaptor-related protein complex 1, mu 2 subunit	6257	0.1
chr10_3511482_3511923	0.15	RP11-184A2.3		281557	0.01
chr4_78114724_78115069	0.15	CCNG2	cyclin G2	35317	0.18
chr10_49893584_49893845	0.15	WDFY4	WDFY family member 4	793	0.69
chr16_70473041_70473208	0.15	ST3GAL2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	133	0.94
chr1_156024285_156024442	0.15	LAMTOR2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	180	0.82
chr17_76124929_76125236	0.14	TMC6	transmembrane channel-like 6	219	0.87
chr14_90863868_90864201	0.14	CALM1	calmodulin 1 (phosphorylase kinase, delta)	572	0.74
chr20_30160458_30160983	0.14	HM13-AS1	HM13 antisense RNA 1	346	0.8
chr12_27090458_27090857	0.14	ASUN	asunder spermatogenesis regulator	248	0.78
chr19_45595083_45595471	0.14	PPP1R37	protein phosphatase 1, regulatory subunit 37	941	0.32
chr10_75632981_75633391	0.14	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	1033	0.4
chr17_76127593_76127800	0.14	TMC6	transmembrane channel-like 6	792	0.35
chr1_150551829_150551980	0.14	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	102	0.92
chr14_69259320_69259636	0.14	ZFP36L1	ZFP36 ring finger protein-like 1	479	0.84
chr1_2066282_2066433	0.14	PRKCZ	protein kinase C, zeta	72	0.96
chr3_5231543_5231696	0.14	EDEM1	ER degradation enhancer, mannosidase alpha-like 1	1585	0.26
chr22_40390320_40390530	0.14	FAM83F	family with sequence similarity 83, member F	528	0.77
chr9_139237156_139237308	0.14	GPSM1	G-protein signaling modulator 1	8327	0.12
chr19_4610268_4610469	0.14	TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	29162	0.09
chr19_53237403_53237997	0.14	ZNF611	zinc finger protein 611	597	0.71
chr17_74268969_74269120	0.14	UBALD2	UBA-like domain containing 2	7260	0.13
chr1_154975370_154975951	0.14	ZBTB7B	zinc finger and BTB domain containing 7B	365	0.68
chr3_136471001_136471256	0.14	STAG1	stromal antigen 1	80	0.81
chrX_80064048_80064808	0.14	BRWD3	bromodomain and WD repeat domain containing 3	759	0.74

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF740_ZNF219

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.1	0.2	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.3	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.1	0.2	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.1	0.2	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.4	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.2	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.2	GO:0048343	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.2	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.2	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.2	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:1903670	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.2	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.2	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369)
0.0	0.1	GO:0071218	cellular response to misfolded protein(GO:0071218)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0044321	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0072193	positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0034776	response to histamine(GO:0034776)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.1	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.5	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.0	0.1	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.3	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.2	GO:0051322	anaphase(GO:0051322)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0090192	regulation of glomerulus development(GO:0090192)
0.0	0.1	GO:0090504	wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0	0.3	GO:1900077	negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.3	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.3	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.0	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.0	0.0	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.4	GO:0043487	regulation of RNA stability(GO:0043487)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0061054	dermatome development(GO:0061054)
0.0	0.1	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.4	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.0	GO:0003179	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.2	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.0	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0048194	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.2	GO:0016925	protein sumoylation(GO:0016925)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0032415	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.2	GO:0044766	multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0	0.0	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0003094	regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0	0.0	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.0	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.0	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.0	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.3	GO:0019079	viral genome replication(GO:0019079)
0.0	0.1	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0043137	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.2	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.1	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0051984	positive regulation of chromosome segregation(GO:0051984)
0.0	0.2	GO:0016574	histone ubiquitination(GO:0016574)
0.0	0.0	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0002885	positive regulation of hypersensitivity(GO:0002885)
0.0	0.2	GO:0045670	regulation of osteoclast differentiation(GO:0045670)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0048262	determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263)
0.0	0.1	GO:0032292	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.0	GO:2000192	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.2	GO:0030837	negative regulation of actin filament polymerization(GO:0030837)
0.0	0.1	GO:0002717	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.0	GO:0046015	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.0	GO:0046033	AMP metabolic process(GO:0046033)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.4	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	GO:0071986	Ragulator complex(GO:0071986)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.3	GO:0005721	pericentric heterochromatin(GO:0005721)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0000125	PCAF complex(GO:0000125)
0.3	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1	GO:0070820	tertiary granule(GO:0070820)
0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1	GO:0060203	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.2	GO:0071564	npBAF complex(GO:0071564)
0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	GO:0072487	MSL complex(GO:0072487)
0.1	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.1	GO:0016342	catenin complex(GO:0016342)
0.3	GO:0030914	STAGA complex(GO:0030914)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.2	GO:0008091	spectrin(GO:0008091)
0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.3	GO:0031201	SNARE complex(GO:0031201)
0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.1	GO:0031519	PcG protein complex(GO:0031519)
0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.2	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.2	GO:0005844	polysome(GO:0005844)
0.3	GO:0035097	methyltransferase complex(GO:0034708) histone methyltransferase complex(GO:0035097)
0.1	GO:0042555	MCM complex(GO:0042555)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	GO:0031941	filamentous actin(GO:0031941)
0.1	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0031143	pseudopodium(GO:0031143)
0.1	GO:0016461	unconventional myosin complex(GO:0016461)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004904	interferon receptor activity(GO:0004904)
0.1	0.4	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	0.2	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.4	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.2	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.3	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.2	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.8	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.3	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.1	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.5	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.2	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.0	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.0	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.0	GO:0010861	thyroid hormone receptor activator activity(GO:0010861)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0051998	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	ST STAT3 PATHWAY	STAT3 Pathway
0.9	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	PID MYC PATHWAY	C-MYC pathway
0.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.5	PID IFNG PATHWAY	IFN-gamma pathway
0.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.2	PID BCR 5PATHWAY	BCR signaling pathway
0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.3	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.9	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.4	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.0	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.1	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.3	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.1	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.1	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.2	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression