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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for ZNF740_ZNF219

Z-value: 1.09

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Transcription factors associated with ZNF740_ZNF219

Gene Symbol Gene ID Gene Info
ZNF740
ENSG00000139651.9 zinc finger protein 740
ZNF219
ENSG00000165804.11 zinc finger protein 219

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_21554121_21554272ZNF21977910.0900770.723.0e-02Click!
chr14_21571987_21572281ZNF2193960.7209130.665.5e-02Click!
chr14_21566135_21566286ZNF2195890.4603610.627.4e-02Click!
chr14_21572301_21572831ZNF2193150.7923660.627.5e-02Click!
chr14_21556081_21556232ZNF21958310.0963210.531.4e-01Click!
chr12_53574456_53574687ZNF740870.5390000.599.5e-02Click!

Activity of the ZNF740_ZNF219 motif across conditions

Conditions sorted by the z-value of the ZNF740_ZNF219 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr19_10341979_10342223 0.68 DNMT1
 DNA (cytosine-5-)-methyltransferase 1
 139
 0.49
chr11_47421960_47422248 0.67 ENSG00000264583
 .
 417
 0.68
chr17_80176095_80176246 0.59 RP13-516M14.2
4067
 0.12
chr22_44577376_44577610 0.54 PARVG
 parvin, gamma
 215
 0.96
chr17_72743404_72743555 0.46 ENSG00000264624
 .
 1273
 0.21
chr12_54694539_54694712 0.45 NFE2
 nuclear factor, erythroid 2
 174
 0.67
chr7_139761785_139761951 0.39 PARP12
 poly (ADP-ribose) polymerase family, member 12
 1653
 0.43
chr19_912362_912526 0.37 R3HDM4
 R3H domain containing 4
 787
 0.39
chr17_61773603_61773754 0.37 LIMD2
 LIM domain containing 2
 2844
 0.21
chr17_38478045_38478318 0.36 RARA
 retinoic acid receptor, alpha
 3644
 0.15
chr17_43300272_43300459 0.36 CTD-2020K17.1
776
 0.38
chr1_150540056_150540997 0.34 ENSG00000264508
 .
 1190
 0.22
chr9_69785762_69786779 0.34 IGKV1OR-2
 immunoglobulin kappa variable 1/OR-2 (pseudogene)
 8317
 0.25
chrX_40014744_40014994 0.33 BCOR
 BCL6 corepressor
 8987
 0.31
chr7_97910621_97910821 0.31 BRI3
 brain protein I3
 258
 0.91
chr1_40157482_40157633 0.30 HPCAL4
 hippocalcin like 4
 196
 0.61
chr3_107243151_107243484 0.30 BBX
 bobby sox homolog (Drosophila)
 113
 0.98
chr16_85647451_85647602 0.30 GSE1
 Gse1 coiled-coil protein
 568
 0.78
chr1_32314203_32314496 0.29 SPOCD1
 SPOC domain containing 1
 32697
 0.13
chr19_14494334_14494521 0.28 CD97
 CD97 molecule
 2171
 0.24
chr15_31656981_31657132 0.28 KLF13
 Kruppel-like factor 13
 1301
 0.61
chrX_48774424_48774575 0.27 PIM2
 pim-2 oncogene
 1487
 0.23
chr14_52779713_52779864 0.27 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 1235
 0.57
chr11_129872420_129873004 0.27 PRDM10
 PR domain containing 10
 13
 0.98
chr19_52133397_52133630 0.27 SIGLEC5
 sialic acid binding Ig-like lectin 5
 75
 0.95
chr6_4777132_4777289 0.27 CDYL
 chromodomain protein, Y-like
 541
 0.75
chr19_4543528_4543679 0.26 ENSG00000263974
 .
 1604
 0.21
chr2_157189811_157190046 0.26 NR4A2
 nuclear receptor subfamily 4, group A, member 2
 696
 0.78
chr17_56405619_56405770 0.26 BZRAP1
 benzodiazepine receptor (peripheral) associated protein 1
 249
 0.73
chr7_21467616_21467934 0.26 SP4
 Sp4 transcription factor
 114
 0.97
chr19_1068246_1068401 0.25 HMHA1
 histocompatibility (minor) HA-1
 826
 0.4
chr10_61659826_61659977 0.25 CCDC6
 coiled-coil domain containing 6
 6513
 0.28
chr18_77793817_77793982 0.25 TXNL4A
 thioredoxin-like 4A
 8
 0.89
chr22_20784096_20784540 0.25 SCARF2
 scavenger receptor class F, member 2
 7794
 0.11
chr2_54787203_54787366 0.25 SPTBN1
 spectrin, beta, non-erythrocytic 1
 1753
 0.36
chr21_44204010_44204161 0.25 AP001627.1
42217
 0.15
chrX_48542765_48543057 0.24 WAS
 Wiskott-Aldrich syndrome
 743
 0.54
chr17_76128459_76128696 0.24 TMC6
 transmembrane channel-like 6
 89
 0.94
chr12_4383631_4384229 0.24 CCND2-AS2
 CCND2 antisense RNA 2
 301
 0.78
chr11_1875039_1875307 0.24 LSP1
 lymphocyte-specific protein 1
 973
 0.36
chr6_137539516_137539806 0.24 IFNGR1
 interferon gamma receptor 1
 10
 0.99
chr9_136933745_136934121 0.23 BRD3
 bromodomain containing 3
 276
 0.9
chr17_40264582_40264792 0.23 DHX58
 DEXH (Asp-Glu-X-His) box polypeptide 58
 45
 0.95
chr1_24969808_24970031 0.23 SRRM1
 serine/arginine repetitive matrix 1
 129
 0.96
chr12_122230893_122231238 0.23 RHOF
 ras homolog family member F (in filopodia)
 201
 0.93
chr2_233925739_233925978 0.23 INPP5D
 inositol polyphosphate-5-phosphatase, 145kDa
 669
 0.7
chr5_39201497_39202174 0.22 FYB
 FYN binding protein
 1294
 0.59
chr8_121823290_121823441 0.22 SNTB1
 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
 1018
 0.42
chr17_66192970_66193249 0.22 LRRC37A16P
 leucine rich repeat containing 37, member A16, pseudogene
 44500
 0.11
chr10_134368672_134368823 0.22 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 17104
 0.21
chr18_72922732_72923415 0.22 TSHZ1
 teashirt zinc finger homeobox 1
 363
 0.87
chr12_31882551_31882882 0.22 AMN1
 antagonist of mitotic exit network 1 homolog (S. cerevisiae)
 608
 0.71
chr5_131832293_131832540 0.22 IRF1
 interferon regulatory factor 1
 5926
 0.15
chr7_91569688_91570087 0.22 AKAP9
 A kinase (PRKA) anchor protein 9
 294
 0.94
chr19_4066716_4067152 0.22 ZBTB7A
 zinc finger and BTB domain containing 7A
 9
 0.96
chrX_147691631_147691782 0.21 AFF2-IT1
 AFF2 intronic transcript 1 (non-protein coding)
 63307
 0.14
chr2_43449640_43450246 0.21 ZFP36L2
 ZFP36 ring finger protein-like 2
 3805
 0.27
chr1_236051645_236051799 0.21 LYST
 lysosomal trafficking regulator
 4850
 0.19
chr9_33817406_33817596 0.21 UBE2R2
 ubiquitin-conjugating enzyme E2R 2
 64
 0.94
chrX_2419173_2419324 0.21 DHRSX
 dehydrogenase/reductase (SDR family) X-linked
 229
 0.51
chr11_2326464_2326615 0.21 TSPAN32
 tetraspanin 32
 2441
 0.18
chr6_30798000_30798388 0.21 ENSG00000202241
 .
 33833
 0.07
chrY_2369174_2369325 0.21 ENSG00000251841
 .
 283541
 0.01
chr6_90793980_90794207 0.21 ENSG00000222078
 .
 82868
 0.09
chr12_57870819_57871184 0.21 ARHGAP9
 Rho GTPase activating protein 9
 566
 0.53
chr10_82215935_82216086 0.20 TSPAN14
 tetraspanin 14
 1899
 0.36
chr19_12949779_12950060 0.20 MAST1
 microtubule associated serine/threonine kinase 1
 571
 0.48
chr12_94544055_94544362 0.20 PLXNC1
 plexin C1
 1709
 0.42
chr14_105527834_105528220 0.20 GPR132
 G protein-coupled receptor 132
 3740
 0.23
chrX_131157971_131158122 0.20 MST4
 Serine/threonine-protein kinase MST4
 410
 0.87
chr2_98547935_98548086 0.20 ENSG00000238719
 .
 18430
 0.21
chr11_640222_640373 0.20 DRD4
 dopamine receptor D4
 3004
 0.11
chr14_99735608_99735969 0.20 BCL11B
 B-cell CLL/lymphoma 11B (zinc finger protein)
 1777
 0.38
chr1_27883616_27883836 0.20 RP1-159A19.4
31410
 0.13
chr1_156124352_156124692 0.20 SEMA4A
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
 360
 0.78
chr3_43329026_43329294 0.20 SNRK
 SNF related kinase
 1082
 0.53
chr6_1610062_1610262 0.20 FOXC1
 forkhead box C1
 519
 0.87
chr4_38665848_38666421 0.20 RP11-617D20.1
115
 0.61
chr7_949432_949583 0.20 ADAP1
 ArfGAP with dual PH domains 1
 4793
 0.16
chr12_51611544_51611860 0.20 POU6F1
 POU class 6 homeobox 1
 225
 0.9
chr18_60987754_60988433 0.20 BCL2
 B-cell CLL/lymphoma 2
 732
 0.64
chr17_29637369_29637894 0.20 EVI2B
 ecotropic viral integration site 2B
 3471
 0.16
chr19_3035801_3036232 0.19 TLE2
 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
 6404
 0.13
chr15_69075318_69075469 0.19 ENSG00000265195
 .
 18871
 0.22
chr17_21156722_21156881 0.19 C17orf103
 chromosome 17 open reading frame 103
 79
 0.97
chr19_16774664_16774815 0.19 TMEM38A
 transmembrane protein 38A
 2667
 0.14
chr17_57643262_57643540 0.19 DHX40
 DEAH (Asp-Glu-Ala-His) box polypeptide 40
 417
 0.85
chr19_6481304_6482171 0.19 DENND1C
 DENN/MADD domain containing 1C
 27
 0.95
chr8_38759681_38760174 0.19 PLEKHA2
 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
 1065
 0.52
chr1_151431863_151432024 0.19 POGZ
 pogo transposable element with ZNF domain
 2
 0.96
chr11_441689_441900 0.19 ANO9
 anoctamin 9
 217
 0.82
chr18_60194123_60194717 0.19 ZCCHC2
 zinc finger, CCHC domain containing 2
 3568
 0.33
chr12_124942372_124942523 0.19 NCOR2
 nuclear receptor corepressor 2
 25868
 0.25
chr17_55334331_55334657 0.19 MSI2
 musashi RNA-binding protein 2
 115
 0.98
chr20_48329140_48329431 0.19 B4GALT5
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
 1130
 0.5
chr1_26646074_26646278 0.19 UBXN11
 UBX domain protein 11
 1322
 0.27
chr7_45067326_45068016 0.18 CCM2
 cerebral cavernous malformation 2
 400
 0.81
chr17_4403063_4403461 0.18 AC118754.4
293
 0.8
chr19_42784997_42785148 0.18 CIC
 capicua transcriptional repressor
 3100
 0.12
chr19_47615950_47616307 0.18 SAE1
 SUMO1 activating enzyme subunit 1
 403
 0.69
chr9_140348775_140349192 0.18 NSMF
 NMDA receptor synaptonuclear signaling and neuronal migration factor
 39
 0.96
chrX_12990058_12990209 0.18 TMSB4X
 thymosin beta 4, X-linked
 3094
 0.3
chr7_158656531_158656832 0.18 WDR60
 WD repeat domain 60
 5456
 0.27
chr13_74708290_74708441 0.18 KLF12
 Kruppel-like factor 12
 29
 0.99
chr15_78361308_78361764 0.18 TBC1D2B
 TBC1 domain family, member 2B
 3071
 0.18
chr15_41219932_41220083 0.18 DLL4
 delta-like 4 (Drosophila)
 1584
 0.27
chr22_39323214_39323365 0.18 APOBEC3A
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
 25467
 0.12
chr5_156696225_156696376 0.18 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 62
 0.96
chr15_100106167_100106396 0.18 MEF2A
 myocyte enhancer factor 2A
 11
 0.98
chr17_27139690_27139995 0.17 FAM222B
 family with sequence similarity 222, member B
 389
 0.7
chr1_21659698_21659849 0.17 ECE1
 endothelin converting enzyme 1
 12224
 0.21
chr15_65477311_65477678 0.17 CLPX
 caseinolytic mitochondrial matrix peptidase chaperone subunit
 186
 0.93
chr15_41953518_41954024 0.17 MGA
 MGA, MAX dimerization protein
 1161
 0.47
chr6_30649932_30650278 0.17 PPP1R18
 protein phosphatase 1, regulatory subunit 18
 4888
 0.08
chr14_74551356_74551507 0.17 LIN52
 lin-52 homolog (C. elegans)
 68
 0.72
chr1_27816833_27817254 0.17 WASF2
 WAS protein family, member 2
 374
 0.86
chr9_20622216_20622410 0.17 MLLT3
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
 201
 0.95
chr16_10710662_10710813 0.17 EMP2
 epithelial membrane protein 2
 36182
 0.13
chr11_2159500_2159786 0.17 IGF2
 insulin-like growth factor 2 (somatomedin A)
 561
 0.59
chr5_88589582_88589733 0.17 MEF2C-AS1
 MEF2C antisense RNA 1
 124967
 0.06
chr9_135114959_135115110 0.17 ENSG00000221105
 .
 24772
 0.21
chr14_90084669_90085459 0.17 FOXN3
 forkhead box N3
 410
 0.78
chr11_108463883_108464034 0.16 EXPH5
 exophilin 5
 416
 0.89
chr17_2717574_2718059 0.16 RAP1GAP2
 RAP1 GTPase activating protein 2
 18040
 0.17
chr2_43451286_43451513 0.16 ZFP36L2
 ZFP36 ring finger protein-like 2
 2349
 0.34
chr19_15574852_15575181 0.16 RASAL3
 RAS protein activator like 3
 366
 0.8
chr19_17958305_17958511 0.16 JAK3
 Janus kinase 3
 418
 0.74
chr2_178129639_178129940 0.16 NFE2L2
 nuclear factor, erythroid 2-like 2
 70
 0.91
chr7_129588935_129590397 0.16 UBE2H
 ubiquitin-conjugating enzyme E2H
 1501
 0.28
chr8_145027093_145027557 0.16 PLEC
 plectin
 763
 0.48
chr10_3822916_3823697 0.16 KLF6
 Kruppel-like factor 6
 4079
 0.25
chr8_144108277_144108585 0.16 LY6E
 lymphocyte antigen 6 complex, locus E
 8457
 0.17
chr8_145639102_145639331 0.16 SLC39A4
 solute carrier family 39 (zinc transporter), member 4
 2680
 0.09
chr21_40759688_40760056 0.16 WRB
 tryptophan rich basic protein
 181
 0.93
chr2_237880489_237880640 0.16 ENSG00000202341
 .
 43384
 0.17
chr14_24780359_24781199 0.16 LTB4R
 leukotriene B4 receptor
 74
 0.58
chr7_50345445_50345596 0.16 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 1142
 0.64
chr2_85166549_85166831 0.16 KCMF1
 potassium channel modulatory factor 1
 31526
 0.15
chr7_1979405_1979706 0.16 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 630
 0.8
chr16_85558650_85558942 0.16 ENSG00000264203
 .
 83698
 0.08
chr10_75633716_75633937 0.16 CAMK2G
 calcium/calmodulin-dependent protein kinase II gamma
 393
 0.78
chrX_39956550_39956704 0.16 BCOR
 BCL6 corepressor
 29
 0.99
chr19_912608_912979 0.16 R3HDM4
 R3H domain containing 4
 438
 0.64
chr11_66405551_66405805 0.16 RBM4
 RNA binding motif protein 4
 410
 0.71
chr22_32313508_32313842 0.16 C22orf24
 chromosome 22 open reading frame 24
 20728
 0.14
chr12_122243825_122244586 0.16 SETD1B
 SET domain containing 1B
 1567
 0.32
chr16_85646303_85646802 0.16 GSE1
 Gse1 coiled-coil protein
 211
 0.95
chrY_1522891_1523042 0.16 NA
 NA
 > 106
 NA
chr21_46348074_46348493 0.16 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 350
 0.75
chr3_194207533_194207696 0.16 ATP13A3
 ATPase type 13A3
 226
 0.77
chr9_130539046_130539317 0.16 SH2D3C
 SH2 domain containing 3C
 1839
 0.17
chr15_25684395_25684621 0.16 UBE3A
 ubiquitin protein ligase E3A
 380
 0.82
chr10_126849381_126849702 0.16 CTBP2
 C-terminal binding protein 2
 54
 0.99
chr16_3005959_3006166 0.15 LA16c-321D4.2
1785
 0.16
chr1_154976315_154976466 0.15 ZBTB7B
 zinc finger and BTB domain containing 7B
 1095
 0.25
chr17_7787815_7787966 0.15 CHD3
 chromodomain helicase DNA binding protein 3
 234
 0.73
chr17_32965108_32965375 0.15 TMEM132E
 transmembrane protein 132E
 57473
 0.13
chr11_71935004_71935259 0.15 INPPL1
 inositol polyphosphate phosphatase-like 1
 143
 0.92
chr8_61591908_61592174 0.15 CHD7
 chromodomain helicase DNA binding protein 7
 82
 0.98
chr19_14887538_14887792 0.15 EMR2
 egf-like module containing, mucin-like, hormone receptor-like 2
 11
 0.97
chr19_6728541_6728856 0.15 C3
 complement component 3
 1875
 0.22
chr4_185188898_185189263 0.15 ENSG00000221523
 .
 496
 0.82
chr14_22958789_22958996 0.15 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 2721
 0.15
chr12_6716856_6717254 0.15 CHD4
 chromodomain helicase DNA binding protein 4
 413
 0.67
chr16_85934507_85934793 0.15 IRF8
 interferon regulatory factor 8
 1645
 0.44
chr17_29820809_29821042 0.15 RAB11FIP4
 RAB11 family interacting protein 4 (class II)
 5799
 0.15
chr10_126840512_126840747 0.15 CTBP2
 C-terminal binding protein 2
 6656
 0.3
chr11_119598080_119598587 0.15 PVRL1
 poliovirus receptor-related 1 (herpesvirus entry mediator C)
 930
 0.54
chrX_70474174_70474507 0.15 ZMYM3
 zinc finger, MYM-type 3
 49
 0.97
chr7_73119920_73120071 0.15 ENSG00000265724
 .
 5652
 0.11
chr20_4804308_4804651 0.15 RASSF2
 Ras association (RalGDS/AF-6) domain family member 2
 188
 0.95
chr1_212781685_212782134 0.15 ATF3
 activating transcription factor 3
 103
 0.96
chr2_214006925_214007076 0.15 IKZF2
 IKAROS family zinc finger 2 (Helios)
 6353
 0.32
chr2_36683900_36684051 0.15 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 56858
 0.13
chr18_5295757_5296173 0.15 ZBTB14
 zinc finger and BTB domain containing 14
 74
 0.98
chr19_10704173_10704324 0.15 AP1M2
 adaptor-related protein complex 1, mu 2 subunit
 6257
 0.1
chr10_3511482_3511923 0.15 RP11-184A2.3
281557
 0.01
chr4_78114724_78115069 0.15 CCNG2
 cyclin G2
 35317
 0.18
chr10_49893584_49893845 0.15 WDFY4
 WDFY family member 4
 793
 0.69
chr16_70473041_70473208 0.15 ST3GAL2
 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
 133
 0.94
chr1_156024285_156024442 0.15 LAMTOR2
 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
 180
 0.82
chr17_76124929_76125236 0.14 TMC6
 transmembrane channel-like 6
 219
 0.87
chr14_90863868_90864201 0.14 CALM1
 calmodulin 1 (phosphorylase kinase, delta)
 572
 0.74
chr20_30160458_30160983 0.14 HM13-AS1
 HM13 antisense RNA 1
 346
 0.8
chr12_27090458_27090857 0.14 ASUN
 asunder spermatogenesis regulator
 248
 0.78
chr19_45595083_45595471 0.14 PPP1R37
 protein phosphatase 1, regulatory subunit 37
 941
 0.32
chr10_75632981_75633391 0.14 CAMK2G
 calcium/calmodulin-dependent protein kinase II gamma
 1033
 0.4
chr17_76127593_76127800 0.14 TMC6
 transmembrane channel-like 6
 792
 0.35
chr1_150551829_150551980 0.14 MCL1
 myeloid cell leukemia sequence 1 (BCL2-related)
 102
 0.92
chr14_69259320_69259636 0.14 ZFP36L1
 ZFP36 ring finger protein-like 1
 479
 0.84
chr1_2066282_2066433 0.14 PRKCZ
 protein kinase C, zeta
 72
 0.96
chr3_5231543_5231696 0.14 EDEM1
 ER degradation enhancer, mannosidase alpha-like 1
 1585
 0.26
chr22_40390320_40390530 0.14 FAM83F
 family with sequence similarity 83, member F
 528
 0.77
chr9_139237156_139237308 0.14 GPSM1
 G-protein signaling modulator 1
 8327
 0.12
chr19_4610268_4610469 0.14 TNFAIP8L1
 tumor necrosis factor, alpha-induced protein 8-like 1
 29162
 0.09
chr19_53237403_53237997 0.14 ZNF611
 zinc finger protein 611
 597
 0.71
chr17_74268969_74269120 0.14 UBALD2
 UBA-like domain containing 2
 7260
 0.13
chr1_154975370_154975951 0.14 ZBTB7B
 zinc finger and BTB domain containing 7B
 365
 0.68
chr3_136471001_136471256 0.14 STAG1
 stromal antigen 1
 80
 0.81
chrX_80064048_80064808 0.14 BRWD3
 bromodomain and WD repeat domain containing 3
 759
 0.74

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF740_ZNF219

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.1 0.2 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.1 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.3 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.1 0.2 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.1 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.2 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:0048343 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.1 GO:0052251 induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0 0.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0009215 purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0033622 integrin activation(GO:0033622)
0.0 0.2 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:1903670 regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0 0.2 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.2 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369)
0.0 0.1 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.1 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0044321 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.0 GO:0072193 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:0034776 response to histamine(GO:0034776)
0.0 0.0 GO:0048541 Peyer's patch development(GO:0048541)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.1 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.1 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.3 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.1 GO:0060287 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.2 GO:0051322 anaphase(GO:0051322)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0046049 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.0 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0090192 regulation of glomerulus development(GO:0090192)
0.0 0.1 GO:0090504 wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0 0.3 GO:1900077 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.3 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:1901722 regulation of cell proliferation involved in kidney development(GO:1901722)
0.0 0.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0060317 cardiac epithelial to mesenchymal transition(GO:0060317)
0.0 0.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.0 GO:0032656 regulation of interleukin-13 production(GO:0032656)
0.0 0.0 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.0 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.4 GO:0043487 regulation of RNA stability(GO:0043487)
0.0 0.1 GO:0043276 anoikis(GO:0043276)
0.0 0.0 GO:0061054 dermatome development(GO:0061054)
0.0 0.1 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.0 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.0 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.0 GO:0003179 heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.2 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.0 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0048194 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.0 GO:0032415 regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.2 GO:0044766 multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0 0.0 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.1 GO:0042119 neutrophil activation(GO:0042119)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0003094 regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0 0.0 GO:0009191 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:0002327 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.0 GO:0043173 nucleotide salvage(GO:0043173)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.0 GO:0070601 centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.0 GO:0009299 mRNA transcription(GO:0009299)
0.0 0.0 GO:0010107 potassium ion import(GO:0010107)
0.0 0.0 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.3 GO:0019079 viral genome replication(GO:0019079)
0.0 0.1 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.0 GO:0043137 DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0 0.2 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.1 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.2 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.0 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0002885 positive regulation of hypersensitivity(GO:0002885)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.0 GO:0071801 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.0 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.0 GO:2000192 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.2 GO:0030837 negative regulation of actin filament polymerization(GO:0030837)
0.0 0.1 GO:0002717 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.0 GO:0046015 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.0 GO:0046033 AMP metabolic process(GO:0046033)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.3 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0070820 tertiary granule(GO:0070820)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0031211 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0031201 SNARE complex(GO:0031201)
0.0 0.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.3 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.1 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0035097 methyltransferase complex(GO:0034708) histone methyltransferase complex(GO:0035097)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0016461 unconventional myosin complex(GO:0016461)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004904 interferon receptor activity(GO:0004904)
0.1 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.4 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.2 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.3 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0 0.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0001077 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.3 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.0 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.0 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.2 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.0 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.0 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.0 GO:0010861 thyroid hormone receptor activator activity(GO:0010861)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.0 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.0 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.5 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.0 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.1 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.2 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.0 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.1 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.3 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression