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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ZNF8

Z-value: 1.02

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Transcription factors associated with ZNF8

Gene Symbol	Gene ID	Gene Info
ZNF8 Ensembl NCBI GeneCards UniProt	ENSG00000083842.8	ZNF8
ZNF8 Ensembl NCBI GeneCards UniProt	ENSG00000273439.1	ZNF8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ZNF8	chr19_58791267_58791418	1024	0.277306	0.82	7.3e-03	Click!
ZNF8	chr19_58790338_58791095	398	0.513430	0.59	9.5e-02	Click!
ZNF8	chr19_58805596_58805747	15353	0.078411	-0.05	9.1e-01	Click!

Activity of the ZNF8 motif across conditions

Conditions sorted by the z-value of the ZNF8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_12575381_12575532	0.51	TYRP1	tyrosinase-related protein 1	109983	0.07
chr17_7607729_7607918	0.45	EFNB3	ephrin-B3	697	0.47
chr17_57439920_57440434	0.44	ENSG00000263857	.	3267	0.22
chr10_135193239_135193390	0.39	AL360181.1	Uncharacterized protein	212	0.71
chr7_72974672_72974823	0.38	BCL7B	B-cell CLL/lymphoma 7B	2415	0.22
chr6_119029777_119030724	0.37	CEP85L	centrosomal protein 85kDa-like	981	0.69
chr12_104851638_104851843	0.36	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	961	0.68
chr17_47271115_47271274	0.35	GNGT2	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	15080	0.14
chr3_114014633_114014828	0.35	TIGIT	T cell immunoreceptor with Ig and ITIM domains	896	0.58
chr9_95055581_95055984	0.34	IARS	isoleucyl-tRNA synthetase	141	0.91
chr1_36042129_36042429	0.34	RP4-728D4.2		1051	0.43
chr1_172109378_172109611	0.33	ENSG00000207949	.	1447	0.39
chr8_117884616_117884915	0.33	RAD21	RAD21 homolog (S. pombe)	1834	0.24
chr21_17681930_17682081	0.32	ENSG00000201025	.	24916	0.27
chr14_23398675_23398826	0.32	PRMT5	protein arginine methyltransferase 5	44	0.51
chr11_105392577_105392728	0.31	GRIA4	glutamate receptor, ionotropic, AMPA 4	88069	0.1
chr15_89179199_89179367	0.30	ISG20	interferon stimulated exonuclease gene 20kDa	101	0.96
chrX_72783288_72783711	0.30	CHIC1	cysteine-rich hydrophobic domain 1	455	0.89
chr2_235403849_235404784	0.30	ARL4C	ADP-ribosylation factor-like 4C	928	0.74
chr17_71088602_71088815	0.30	SLC39A11	solute carrier family 39, member 11	107	0.98
chr6_28180364_28180829	0.30	ZSCAN9	zinc finger and SCAN domain containing 9	12068	0.13
chrX_122318159_122318585	0.30	GRIA3	glutamate receptor, ionotropic, AMPA 3	36	0.99
chr1_19281880_19282035	0.29	IFFO2	intermediate filament family orphan 2	235	0.94
chr19_41732107_41732593	0.29	AXL	AXL receptor tyrosine kinase	310	0.83
chr4_81124101_81124367	0.29	PRDM8	PR domain containing 8	5576	0.24
chr10_116584415_116584656	0.29	FAM160B1	family with sequence similarity 160, member B1	3006	0.37
chr20_1099338_1099605	0.29	PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	191	0.95
chr13_19203049_19203245	0.29	ENSG00000223024	.	240284	0.02
chr5_43192499_43192793	0.28	NIM1K	NIM1 serine/threonine protein kinase	308	0.92
chr7_43945567_43945756	0.28	URGCP-MRPS24	URGCP-MRPS24 readthrough	527	0.44
chr21_26934419_26935339	0.28	ENSG00000234883	.	11413	0.19
chr16_66652344_66652579	0.27	CMTM3	CKLF-like MARVEL transmembrane domain containing 3	13037	0.11
chr5_134210294_134210605	0.27	TXNDC15	thioredoxin domain containing 15	337	0.87
chr12_26844097_26844392	0.27	RP11-666F17.1		67942	0.12
chr17_27169901_27170114	0.26	FAM222B	family with sequence similarity 222, member B	150	0.9
chrX_106243219_106243547	0.26	MORC4	MORC family CW-type zinc finger 4	75	0.98
chr19_17357023_17357252	0.26	NR2F6	nuclear receptor subfamily 2, group F, member 6	388	0.67
chr6_158589460_158589825	0.26	GTF2H5	general transcription factor IIH, polypeptide 5	258	0.57
chr10_72201220_72201371	0.26	NODAL	nodal growth differentiation factor	128	0.96
chr12_21606326_21606605	0.26	PYROXD1	pyridine nucleotide-disulphide oxidoreductase domain 1	15616	0.17
chr11_14520450_14521043	0.25	COPB1	coatomer protein complex, subunit beta 1	611	0.75
chr10_105605562_105605713	0.25	SH3PXD2A	SH3 and PX domains 2A	9527	0.2
chr19_34012835_34013082	0.25	PEPD	peptidase D	258	0.95
chr19_37407398_37407734	0.25	ZNF568	zinc finger protein 568	209	0.67
chr10_94334737_94334888	0.25	IDE	insulin-degrading enzyme	979	0.59
chr16_49889200_49889463	0.25	ZNF423	zinc finger protein 423	715	0.75
chr2_197124773_197125094	0.25	AC020571.3		95	0.97
chr12_120876193_120876532	0.25	AL021546.6	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial	361	0.52
chr16_4818494_4818716	0.25	ZNF500	zinc finger protein 500	980	0.39
chr14_33929813_33929964	0.25	NPAS3	neuronal PAS domain protein 3	245370	0.02
chr11_118964238_118964465	0.24	H2AFX	H2A histone family, member X	1826	0.14
chr3_52737763_52738047	0.24	GLT8D1	glycosyltransferase 8 domain containing 1	270	0.75
chr17_78711366_78711517	0.24	RP11-28G8.1		67991	0.11
chr19_39835748_39835899	0.24	SAMD4B	sterile alpha motif domain containing 4B	2715	0.12
chr5_127420764_127420915	0.24	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	1299	0.63
chr13_99958437_99958588	0.24	GPR183	G protein-coupled receptor 183	1147	0.52
chr2_30458178_30458329	0.24	LBH	limb bud and heart development	3207	0.3
chr9_123555070_123555612	0.24	FBXW2	F-box and WD repeat domain containing 2	314	0.9
chr5_110559444_110559831	0.24	CAMK4	calcium/calmodulin-dependent protein kinase IV	11	0.98
chrX_53251626_53252025	0.24	KDM5C	lysine (K)-specific demethylase 5C	2533	0.26
chr3_197477598_197478224	0.23	FYTTD1	forty-two-three domain containing 1	650	0.6
chr17_3598807_3599359	0.23	P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5	244	0.86
chr20_57427056_57427350	0.23	GNAS	GNAS complex locus	566	0.59
chr19_45251774_45251925	0.23	BCL3	B-cell CLL/lymphoma 3	45	0.96
chr12_6184333_6184641	0.23	ENSG00000240533	.	20649	0.2
chr10_105880540_105880741	0.23	SFR1	SWI5-dependent recombination repair 1	1176	0.46
chr18_14131976_14132486	0.23	ZNF519	zinc finger protein 519	196	0.93
chr12_55375935_55376187	0.23	TESPA1	thymocyte expressed, positive selection associated 1	439	0.86
chr2_65577328_65577479	0.23	SPRED2	sprouty-related, EVH1 domain containing 2	5483	0.26
chr10_5727764_5728131	0.23	FAM208B	family with sequence similarity 208, member B	1036	0.5
chr13_25861194_25861587	0.23	MTMR6	myotubularin related protein 6	314	0.89
chr16_66461764_66462073	0.23	BEAN1	brain expressed, associated with NEDD4, 1	644	0.68
chr15_85523909_85524155	0.23	PDE8A	phosphodiesterase 8A	288	0.91
chr12_52463075_52463333	0.22	C12orf44	chromosome 12 open reading frame 44	551	0.63
chr15_25201119_25201420	0.22	SNURF	SNRPN upstream reading frame protein	1108	0.23
chr1_151811278_151811720	0.22	C2CD4D	C2 calcium-dependent domain containing 4D	1534	0.18
chr5_138676935_138677379	0.22	PAIP2	poly(A) binding protein interacting protein 2	119	0.93
chr14_90865510_90865807	0.22	CALM1	calmodulin 1 (phosphorylase kinase, delta)	1052	0.5
chrX_92928498_92928999	0.22	NAP1L3	nucleosome assembly protein 1-like 3	181	0.61
chr2_96809635_96809786	0.21	DUSP2	dual specificity phosphatase 2	1469	0.34
chr1_70670699_70671189	0.21	LRRC40	leucine rich repeat containing 40	359	0.53
chr1_236960314_236960595	0.21	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	1472	0.52
chr8_38648804_38648992	0.21	TACC1	transforming, acidic coiled-coil containing protein 1	3217	0.23
chr16_72128402_72128590	0.21	TXNL4B	thioredoxin-like 4B	166	0.84
chr14_61811311_61811517	0.21	PRKCH	protein kinase C, eta	372	0.88
chr8_124172522_124172673	0.21	FAM83A	family with sequence similarity 83, member A	18690	0.11
chr5_10353857_10354094	0.21	MARCH6	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	96	0.72
chr15_68545515_68545666	0.21	CLN6	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	3854	0.2
chr12_125424789_125424964	0.21	UBC	ubiquitin C	22962	0.14
chr1_40420311_40420468	0.21	MFSD2A	major facilitator superfamily domain containing 2A	413	0.81
chr10_497094_497245	0.21	RP11-490E15.2		13668	0.2
chr3_104938786_104938937	0.21	ALCAM	activated leukocyte cell adhesion molecule	146892	0.05
chr2_73612447_73612786	0.21	ALMS1	Alstrom syndrome 1	270	0.93
chr12_92949870_92950021	0.20	ENSG00000238865	.	11182	0.27
chrX_130946561_130947407	0.20	ENSG00000200587	.	126000	0.06
chr6_104730379_104730530	0.20	ENSG00000252944	.	484243	0.01
chr2_194347562_194347833	0.20	NA	NA	> 10⁶	NA
chr10_95653765_95654590	0.20	SLC35G1	solute carrier family 35, member G1	447	0.88
chr9_34178665_34178872	0.20	UBAP1	ubiquitin associated protein 1	235	0.91
chr1_228593151_228593670	0.20	TRIM11	tripartite motif containing 11	195	0.86
chr5_176023650_176023811	0.20	GPRIN1	G protein regulated inducer of neurite outgrowth 1	13404	0.11
chrY_17567786_17567937	0.20	ENSG00000252664	.	606785	0.0
chr9_98279774_98279925	0.20	PTCH1	patched 1	510	0.75
chr12_48745022_48745253	0.20	ZNF641	zinc finger protein 641	60	0.85
chr20_34681844_34681995	0.19	EPB41L1	erythrocyte membrane protein band 4.1-like 1	1160	0.49
chr22_25506661_25506812	0.19	CTA-221G9.11		1923	0.39
chr17_46633195_46633347	0.19	HOXB3	homeobox B3	612	0.44
chr12_40012503_40012670	0.19	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	967	0.63
chr2_133402716_133402880	0.19	AC010974.3		15301	0.22
chr1_246670350_246670537	0.19	SMYD3	SET and MYND domain containing 3	76	0.98
chr21_16427122_16427273	0.19	NRIP1	nuclear receptor interacting protein 1	9929	0.27
chr2_142888569_142888850	0.19	LRP1B	low density lipoprotein receptor-related protein 1B	135	0.97
chr12_90100416_90100567	0.19	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	2117	0.33
chr12_56881156_56881307	0.18	GLS2	glutaminase 2 (liver, mitochondrial)	671	0.58
chr1_243584631_243584835	0.18	ENSG00000265201	.	75255	0.11
chr14_22409532_22409683	0.18	ENSG00000222776	.	160822	0.03
chr5_175621560_175621795	0.18	SIMC1	SUMO-interacting motifs containing 1	43688	0.14
chr1_27126960_27127111	0.18	PIGV	phosphatidylinositol glycan anchor biosynthesis, class V	11616	0.11
chr19_36035577_36035728	0.18	AD000090.2		290	0.72
chr13_107220642_107220857	0.18	ARGLU1	arginine and glutamate rich 1	237	0.95
chr11_62622399_62622788	0.18	ENSG00000255717	.	38	0.91
chr19_45312390_45312692	0.18	BCAM	basal cell adhesion molecule (Lutheran blood group)	163	0.92
chr18_67614161_67614403	0.17	CD226	CD226 molecule	373	0.92
chr10_97667413_97667615	0.17	ENTPD1-AS1	ENTPD1 antisense RNA 1	18	0.66
chr6_26158769_26159181	0.17	HIST1H2BD	histone cluster 1, H2bd	601	0.45
chr12_122326288_122326449	0.17	PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	269	0.88
chr1_11845061_11845371	0.17	C1orf167	chromosome 1 open reading frame 167	5342	0.12
chr6_24743062_24743323	0.17	C6orf62	chromosome 6 open reading frame 62	22128	0.12
chr11_28119423_28119574	0.17	METTL15	methyltransferase like 15	10297	0.21
chrX_1653880_1654070	0.17	P2RY8	purinergic receptor P2Y, G-protein coupled, 8	2025	0.36
chr12_27090977_27091227	0.17	ASUN	asunder spermatogenesis regulator	135	0.61
chr11_48041704_48041855	0.17	AC103828.1		4372	0.25
chr5_49736865_49737170	0.17	EMB	embigin	167	0.98
chr9_99181784_99182155	0.17	ZNF367	zinc finger protein 367	1358	0.46
chr8_61429545_61429985	0.17	RAB2A	RAB2A, member RAS oncogene family	25	0.98
chrY_1603880_1604065	0.17	NA	NA	> 10⁶	NA
chr1_72751044_72751264	0.17	NEGR1	neuronal growth regulator 1	2737	0.44
chr19_4969639_4969870	0.16	KDM4B	lysine (K)-specific demethylase 4B	611	0.72
chr6_46293041_46293192	0.16	RCAN2	regulator of calcineurin 2	289	0.94
chr2_225448726_225449293	0.16	CUL3	cullin 3	1056	0.69
chr12_50135384_50135571	0.16	TMBIM6	transmembrane BAX inhibitor motif containing 6	86	0.97
chr15_64915060_64915211	0.16	ENSG00000207223	.	29952	0.13
chr6_30684473_30685093	0.16	MDC1	mediator of DNA-damage checkpoint 1	115	0.89
chr2_149403004_149403363	0.16	EPC2	enhancer of polycomb homolog 2 (Drosophila)	194	0.97
chr8_13123268_13123419	0.16	DLC1	deleted in liver cancer 1	10712	0.27
chr21_35287147_35287573	0.16	LINC00649	long intergenic non-protein coding RNA 649	478	0.61
chr21_46289667_46289837	0.16	PTTG1IP	pituitary tumor-transforming 1 interacting protein	3854	0.16
chr2_9697178_9697329	0.16	ADAM17	ADAM metallopeptidase domain 17	1332	0.42
chr17_34136054_34136260	0.16	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	302	0.81
chr7_137685587_137685789	0.16	CREB3L2	cAMP responsive element binding protein 3-like 2	1105	0.53
chr7_48018318_48018852	0.16	HUS1	HUS1 checkpoint homolog (S. pombe)	516	0.79
chrX_131341527_131341678	0.16	RAP2C-AS1	RAP2C antisense RNA 1	9573	0.22
chr7_157131771_157131922	0.16	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	669	0.77
chr1_49242211_49242511	0.16	BEND5	BEN domain containing 5	229	0.96
chr16_30640046_30640198	0.16	ZNF689	zinc finger protein 689	18422	0.07
chr4_6711000_6711263	0.16	MRFAP1L1	Morf4 family associated protein 1-like 1	476	0.75
chr19_58459192_58459462	0.16	ZNF256	zinc finger protein 256	284	0.84
chr17_61523601_61523752	0.16	CYB561	cytochrome b561	9	0.97
chr6_160560270_160560421	0.16	SLC22A1	solute carrier family 22 (organic cation transporter), member 1	9552	0.25
chr5_95992763_95992914	0.16	CAST	calpastatin	4939	0.22
chr16_57496565_57496748	0.15	POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	357	0.81
chr22_45664670_45664855	0.15	UPK3A	uroplakin 3A	16101	0.16
chr13_20701746_20702011	0.15	GJA3	gap junction protein, alpha 3, 46kDa	33310	0.16
chr16_21964348_21964572	0.15	UQCRC2	ubiquinol-cytochrome c reductase core protein II	232	0.92
chr6_26056150_26056643	0.15	HIST1H1C	histone cluster 1, H1c	303	0.74
chr11_118973164_118973374	0.15	DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	417	0.63
chr2_129075768_129075960	0.15	HS6ST1	heparan sulfate 6-O-sulfotransferase 1	287	0.93
chr19_37063422_37063596	0.15	AC092295.7		463	0.54
chr6_90067633_90067883	0.15	UBE2J1	ubiquitin-conjugating enzyme E2, J1	5191	0.22
chr17_9480443_9480594	0.15	WDR16	WD repeat domain 16	519	0.48
chr19_17941346_17941497	0.15	INSL3	insulin-like 3 (Leydig cell)	9038	0.11
chr16_74641159_74641577	0.15	GLG1	golgi glycoprotein 1	356	0.9
chr6_79788386_79788977	0.15	PHIP	pleckstrin homology domain interacting protein	728	0.79
chr6_26032878_26033311	0.15	HIST1H2AB	histone cluster 1, H2ab	702	0.31
chr2_172289877_172290488	0.15	METTL8	methyltransferase like 8	318	0.7
chr7_112429598_112430043	0.15	TMEM168	transmembrane protein 168	614	0.84
chr1_41177230_41177555	0.15	NFYC	nuclear transcription factor Y, gamma	2177	0.25
chr3_47820837_47820988	0.15	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	2495	0.25
chr17_45899176_45899438	0.15	OSBPL7	oxysterol binding protein-like 7	107	0.94
chr20_47803254_47804087	0.15	STAU1	staufen double-stranded RNA binding protein 1	1234	0.47
chr9_134282757_134283214	0.15	PRRC2B	proline-rich coiled-coil 2B	13505	0.2
chr21_15096270_15096556	0.15	AL050303.1	Uncharacterized protein; cDNA FLJ43689 fis, clone TBAES2003550	42954	0.16
chr10_103814200_103814517	0.15	C10orf76	chromosome 10 open reading frame 76	1592	0.34
chr7_39989218_39989369	0.15	RP11-467D6.1		61	0.83
chr4_89204547_89205147	0.14	PPM1K	protein phosphatase, Mg2+/Mn2+ dependent, 1K	195	0.93
chr6_164530063_164530741	0.14	ENSG00000266128	.	268809	0.02
chr5_67510861_67511301	0.14	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	467	0.86
chr2_113341475_113341929	0.14	CHCHD5	coiled-coil-helix-coiled-coil-helix domain containing 5	316	0.87
chr12_125050945_125051262	0.14	NCOR2	nuclear receptor corepressor 2	907	0.73
chr5_172197544_172197695	0.14	DUSP1	dual specificity phosphatase 1	579	0.67
chr15_29131227_29131499	0.14	APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	54	0.98
chr6_82462588_82463015	0.14	FAM46A	family with sequence similarity 46, member A	310	0.9
chr6_137365071_137365326	0.14	IL20RA	interleukin 20 receptor, alpha	213	0.95
chr2_68946943_68947094	0.14	ARHGAP25	Rho GTPase activating protein 25	9384	0.26
chr14_61790070_61790226	0.14	ENSG00000247287	.	612	0.51
chr17_70715496_70715723	0.14	ENSG00000222545	.	4999	0.28
chr11_66081550_66081990	0.14	RP11-867G23.13		1446	0.16
chr6_157469997_157470201	0.14	ARID1B	AT rich interactive domain 1B (SWI1-like)	54	0.98
chr4_86702026_86702177	0.14	ARHGAP24	Rho GTPase activating protein 24	2242	0.41
chr14_24584036_24584230	0.14	DCAF11	DDB1 and CUL4 associated factor 11	63	0.51

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.1	0.3	GO:0046548	retinal rod cell development(GO:0046548)
0.1	0.2	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.2	GO:0009648	photoperiodism(GO:0009648)
0.1	0.2	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.1	0.2	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.3	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.2	GO:0016198	axon choice point recognition(GO:0016198)
0.0	0.1	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.3	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.2	GO:0002834	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.2	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.2	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0010664	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.2	GO:0048205	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.2	GO:0046653	tetrahydrofolate metabolic process(GO:0046653)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.2	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.2	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.2	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0051461	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0015853	adenine transport(GO:0015853)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.2	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.0	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:1903579	negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0	0.1	GO:0033233	regulation of protein sumoylation(GO:0033233)
0.0	0.3	GO:0007215	glutamate receptor signaling pathway(GO:0007215)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.3	GO:0006829	zinc II ion transport(GO:0006829)
0.0	0.0	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.0	GO:0006012	galactose metabolic process(GO:0006012)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0045022	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.1	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.0	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.0	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.3	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.0	GO:0032232	negative regulation of actin filament bundle assembly(GO:0032232)
0.0	0.3	GO:0000725	double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0010830	regulation of myotube differentiation(GO:0010830)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005827	polar microtubule(GO:0005827)
0.1	0.2	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0045277	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.1	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.2	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.3	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.0	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.0	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.2	GO:0005839	proteasome core complex(GO:0005839)
0.0	0.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.0	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.2	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.3	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.2	GO:0031628	opioid receptor binding(GO:0031628)
0.1	0.3	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.2	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0019238	cyclohydrolase activity(GO:0019238)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.1	GO:0008469	histone-arginine N-methyltransferase activity(GO:0008469)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.3	GO:0004970	ionotropic glutamate receptor activity(GO:0004970)
0.0	0.1	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.0	0.1	GO:0046980	tapasin binding(GO:0046980)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.2	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345)
0.0	0.2	GO:0043236	laminin binding(GO:0043236)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.2	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.0	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.2	GO:0001614	G-protein coupled nucleotide receptor activity(GO:0001608) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0090079	translation activator activity(GO:0008494) translation regulator activity, nucleic acid binding(GO:0090079)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.4	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	PID INSULIN PATHWAY	Insulin Pathway
0.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.5	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1	ST STAT3 PATHWAY	STAT3 Pathway
0.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	PID IFNG PATHWAY	IFN-gamma pathway
0.3	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	PID ERBB4 PATHWAY	ErbB4 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.4	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.4	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.5	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.3	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	Genes involved in p53-Independent G1/S DNA damage checkpoint
0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.3	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.5	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response