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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for ZSCAN4

Z-value: 1.89

Motif logo

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Transcription factors associated with ZSCAN4

Gene Symbol Gene ID Gene Info
ZSCAN4
ENSG00000180532.6 zinc finger and SCAN domain containing 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_58175542_58175994ZSCAN445350.1041770.472.0e-01Click!
chr19_58176040_58176274ZSCAN441460.1074610.442.4e-01Click!

Activity of the ZSCAN4 motif across conditions

Conditions sorted by the z-value of the ZSCAN4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_133748166_133748506 1.32 SLCO2A1
 solute carrier organic anion transporter family, member 2A1
 422
 0.9
chr2_206549618_206550045 1.29 NRP2
 neuropilin 2
 1816
 0.48
chr5_92921472_92921639 0.97 ENSG00000237187
 .
 201
 0.94
chr2_216297601_216297993 0.97 FN1
 fibronectin 1
 2993
 0.27
chr12_108991532_108991806 0.96 TMEM119
 transmembrane protein 119
 115
 0.95
chr2_167232459_167233133 0.95 SCN9A
 sodium channel, voltage-gated, type IX, alpha subunit
 293
 0.93
chr19_16179581_16179939 0.93 TPM4
 tropomyosin 4
 1250
 0.44
chr14_86000741_86001075 0.89 FLRT2
 fibronectin leucine rich transmembrane protein 2
 4336
 0.28
chr10_7670560_7670711 0.86 ITIH5
 inter-alpha-trypsin inhibitor heavy chain family, member 5
 9012
 0.26
chr6_56707059_56707245 0.85 DST
 dystonin
 791
 0.6
chr1_182993880_182994112 0.84 LAMC1
 laminin, gamma 1 (formerly LAMB2)
 1401
 0.44
chr2_33360890_33361153 0.83 LTBP1
 latent transforming growth factor beta binding protein 1
 1297
 0.6
chr18_32290517_32290846 0.82 DTNA
 dystrobrevin, alpha
 420
 0.9
chr11_12309017_12309498 0.81 MICALCL
 MICAL C-terminal like
 810
 0.62
chr4_77356777_77357012 0.80 SHROOM3
 shroom family member 3
 641
 0.68
chr2_190041307_190041749 0.79 COL5A2
 collagen, type V, alpha 2
 3077
 0.31
chr3_87036535_87037613 0.78 VGLL3
 vestigial like 3 (Drosophila)
 2778
 0.42
chr5_155754238_155754771 0.77 SGCD
 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
 737
 0.81
chr22_46473276_46473626 0.77 FLJ27365
 hsa-mir-4763
 2741
 0.14
chr12_2163394_2163601 0.75 CACNA1C
 calcium channel, voltage-dependent, L type, alpha 1C subunit
 768
 0.61
chr3_37903958_37904647 0.75 CTDSPL
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
 637
 0.58
chrX_10586840_10587300 0.75 MID1
 midline 1 (Opitz/BBB syndrome)
 1389
 0.54
chr18_7568558_7569022 0.75 PTPRM
 protein tyrosine phosphatase, receptor type, M
 973
 0.7
chr4_89977525_89978081 0.74 FAM13A
 family with sequence similarity 13, member A
 508
 0.85
chr13_24145710_24146057 0.73 TNFRSF19
 tumor necrosis factor receptor superfamily, member 19
 1080
 0.66
chr7_116167346_116167524 0.73 CAV1
 caveolin 1, caveolae protein, 22kDa
 1088
 0.46
chr6_105628008_105628228 0.73 POPDC3
 popeye domain containing 3
 383
 0.73
chr2_216296592_216296743 0.71 FN1
 fibronectin 1
 4123
 0.25
chr12_3308931_3310293 0.71 TSPAN9
 tetraspanin 9
 729
 0.75
chr6_163817634_163818149 0.69 QKI
 QKI, KH domain containing, RNA binding
 17784
 0.29
chr6_112574710_112575490 0.69 LAMA4
 laminin, alpha 4
 587
 0.75
chr8_30243504_30243875 0.68 RBPMS-AS1
 RBPMS antisense RNA 1
 772
 0.48
chr12_66218083_66218500 0.68 HMGA2
 high mobility group AT-hook 2
 51
 0.98
chr5_158524974_158525234 0.67 EBF1
 early B-cell factor 1
 1597
 0.48
chr10_62332469_62332822 0.66 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 224
 0.97
chr12_50796133_50796284 0.66 LARP4
 La ribonucleoprotein domain family, member 4
 1232
 0.46
chr1_31380173_31380807 0.66 SDC3
 syndecan 3
 1118
 0.44
chr11_27722222_27723091 0.65 BDNF
 brain-derived neurotrophic factor
 56
 0.98
chr16_86542600_86543872 0.65 FOXF1
 forkhead box F1
 897
 0.62
chr17_36621277_36621585 0.65 ARHGAP23
 Rho GTPase activating protein 23
 6749
 0.17
chr1_210436119_210436432 0.64 SERTAD4-AS1
 SERTAD4 antisense RNA 1
 28883
 0.18
chr22_46423027_46423794 0.64 RP6-109B7.5
25563
 0.09
chr16_88219567_88219948 0.63 BANP
 BTG3 associated nuclear protein
 216133
 0.02
chr3_40821863_40822477 0.63 ZNF621
 zinc finger protein 621
 255263
 0.02
chr12_108991360_108991513 0.63 TMEM119
 transmembrane protein 119
 348
 0.83
chr7_132260669_132261651 0.63 PLXNA4
 plexin A4
 69
 0.98
chr5_55117443_55117995 0.62 IL31RA
 interleukin 31 receptor A
 29488
 0.16
chr5_115790032_115790655 0.62 CTB-118N6.3
4917
 0.26
chr1_32263785_32263971 0.62 SPOCD1
 SPOC domain containing 1
 439
 0.79
chr2_66667990_66668184 0.62 MEIS1
 Meis homeobox 1
 277
 0.68
chr3_173113877_173114225 0.62 NLGN1
 neuroligin 1
 23
 0.99
chr2_119602557_119602736 0.61 EN1
 engrailed homeobox 1
 2608
 0.39
chr12_118626563_118627015 0.61 TAOK3
 TAO kinase 3
 1538
 0.42
chr16_14279913_14280368 0.61 MKL2
 MKL/myocardin-like 2
 434
 0.86
chr1_43672267_43672508 0.61 ENSG00000199240
 .
 10299
 0.15
chr2_199965342_199965661 0.61 ENSG00000238698
 .
 90281
 0.1
chr13_36704438_36704640 0.61 DCLK1
 doublecortin-like kinase 1
 904
 0.69
chr12_24103066_24103383 0.60 SOX5
 SRY (sex determining region Y)-box 5
 587
 0.86
chr2_190044770_190044921 0.60 COL5A2
 collagen, type V, alpha 2
 240
 0.95
chr4_158143046_158143598 0.60 GRIA2
 glutamate receptor, ionotropic, AMPA 2
 504
 0.84
chr8_85096596_85096747 0.60 RALYL
 RALY RNA binding protein-like
 211
 0.97
chr2_190042287_190042516 0.59 COL5A2
 collagen, type V, alpha 2
 2204
 0.37
chr2_187406005_187406156 0.58 ZC3H15
 zinc finger CCCH-type containing 15
 34640
 0.15
chr3_161883614_161883765 0.58 OTOL1
 otolin 1
 669093
 0.0
chrX_22318596_22318928 0.58 ZNF645
 zinc finger protein 645
 27697
 0.24
chr6_105388737_105389249 0.57 LIN28B
 lin-28 homolog B (C. elegans)
 15930
 0.23
chr18_53089837_53090372 0.57 TCF4
 transcription factor 4
 361
 0.89
chr19_47473743_47473975 0.57 ENSG00000252071
 .
 22313
 0.15
chr10_45473591_45473742 0.57 C10orf10
 chromosome 10 open reading frame 10
 571
 0.64
chr4_152246816_152247200 0.57 ENSG00000252544
 .
 25338
 0.19
chr9_79520622_79521003 0.56 PRUNE2
 prune homolog 2 (Drosophila)
 189
 0.97
chr18_73350466_73350705 0.56 SMIM21
 small integral membrane protein 21
 210927
 0.02
chr8_85095169_85095335 0.56 RALYL
 RALY RNA binding protein-like
 230
 0.97
chr3_123476244_123476543 0.56 MYLK
 myosin light chain kinase
 36295
 0.15
chrX_107179250_107179655 0.56 RP6-191P20.4
242
 0.93
chr10_104536560_104536809 0.56 WBP1L
 WW domain binding protein 1-like
 678
 0.63
chr7_82073407_82073821 0.55 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 500
 0.89
chr13_31271674_31272060 0.55 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 37778
 0.19
chr5_58592476_58593460 0.55 PDE4D
 phosphodiesterase 4D, cAMP-specific
 21023
 0.29
chr13_76212170_76212445 0.55 LMO7
 LIM domain 7
 1848
 0.28
chr13_111452203_111452465 0.55 LINC00346
 long intergenic non-protein coding RNA 346
 69828
 0.1
chr1_29563184_29564088 0.54 PTPRU
 protein tyrosine phosphatase, receptor type, U
 485
 0.75
chr13_103054295_103054752 0.54 FGF14
 fibroblast growth factor 14
 399
 0.89
chr6_125932782_125933099 0.54 RP11-624M8.1
133234
 0.05
chr10_79685105_79685313 0.54 DLG5
 discs, large homolog 5 (Drosophila)
 1075
 0.43
chr4_170189564_170189726 0.54 SH3RF1
 SH3 domain containing ring finger 1
 1463
 0.54
chr15_96883311_96883827 0.54 ENSG00000222651
 .
 7079
 0.16
chr10_118547485_118547701 0.54 HSPA12A
 heat shock 70kDa protein 12A
 45508
 0.14
chr9_91433553_91433929 0.54 ENSG00000265873
 .
 72921
 0.12
chrX_20135177_20135375 0.53 MAP7D2
 MAP7 domain containing 2
 241
 0.9
chr16_10673584_10673860 0.53 EMP2
 epithelial membrane protein 2
 833
 0.54
chrX_109987052_109987203 0.53 CHRDL1
 chordin-like 1
 51866
 0.18
chr21_32720000_32720175 0.53 TIAM1
 T-cell lymphoma invasion and metastasis 1
 3493
 0.37
chr5_88185268_88186094 0.52 MEF2C-AS1
 MEF2C antisense RNA 1
 404
 0.88
chr6_112651357_112651565 0.52 RFPL4B
 ret finger protein-like 4B
 17071
 0.19
chr5_33937092_33937273 0.51 RXFP3
 relaxin/insulin-like family peptide receptor 3
 691
 0.7
chr9_129884150_129884930 0.51 ANGPTL2
 angiopoietin-like 2
 373
 0.9
chr2_216299709_216300678 0.51 FN1
 fibronectin 1
 597
 0.55
chr19_15219133_15219284 0.51 SYDE1
 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
 436
 0.73
chr2_198538241_198538478 0.50 RFTN2
 raftlin family member 2
 2360
 0.29
chr12_66221542_66221865 0.50 HMGA2
 high mobility group AT-hook 2
 2800
 0.29
chrX_17431119_17431354 0.50 ENSG00000265465
 .
 12768
 0.22
chr3_112931196_112931871 0.50 BOC
 BOC cell adhesion associated, oncogene regulated
 124
 0.97
chr20_58164973_58165317 0.50 PHACTR3
 phosphatase and actin regulator 3
 12581
 0.25
chr19_11892320_11892471 0.50 ZNF441
 zinc finger protein 441
 14488
 0.11
chr6_46816549_46816814 0.50 GPR116
 G protein-coupled receptor 116
 22921
 0.18
chr17_25886913_25887375 0.50 KSR1
 kinase suppressor of ras 1
 22803
 0.19
chr3_173113317_173113831 0.49 NLGN1
 neuroligin 1
 500
 0.89
chr17_56401899_56402577 0.49 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 573
 0.61
chr3_65818040_65818191 0.49 MAGI1-AS1
 MAGI1 antisense RNA 1
 61376
 0.14
chr19_10120368_10120847 0.49 COL5A3
 collagen, type V, alpha 3
 540
 0.61
chr11_66083364_66083632 0.49 CD248
 CD248 molecule, endosialin
 1017
 0.24
chr11_27719069_27719230 0.48 BDNF
 brain-derived neurotrophic factor
 2065
 0.4
chr14_27453693_27453844 0.48 ENSG00000222899
 .
 56909
 0.15
chr8_99439239_99439631 0.48 KCNS2
 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
 185
 0.95
chr11_85885739_85885890 0.47 ENSG00000200877
 .
 21545
 0.2
chr8_19459484_19459946 0.47 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
 291
 0.95
chr22_24640119_24640309 0.47 GGT5
 gamma-glutamyltransferase 5
 813
 0.59
chr3_120167855_120168016 0.47 FSTL1
 follistatin-like 1
 1903
 0.44
chr8_125673018_125673304 0.47 MTSS1
 metastasis suppressor 1
 66696
 0.11
chr17_28847050_28847209 0.47 TBC1D29
 TBC1 domain family, member 29
 37001
 0.11
chr18_75239336_75239487 0.47 ENSG00000199392
 .
 95766
 0.09
chr20_17207159_17207414 0.47 PCSK2
 proprotein convertase subtilisin/kexin type 2
 350
 0.89
chr8_22241251_22241835 0.47 SLC39A14
 solute carrier family 39 (zinc transporter), member 14
 8800
 0.18
chr6_21597329_21597632 0.47 SOX4
 SRY (sex determining region Y)-box 4
 3409
 0.4
chr3_52568044_52568870 0.47 NT5DC2
 5'-nucleotidase domain containing 2
 613
 0.56
chr2_8143991_8144314 0.47 ENSG00000221255
 .
 427180
 0.01
chr8_118743734_118743992 0.47 MED30
 mediator complex subunit 30
 210791
 0.02
chr17_2027134_2027389 0.47 RP11-667K14.5
34286
 0.09
chr20_36450419_36450584 0.47 CTNNBL1
 catenin, beta like 1
 44826
 0.16
chr16_88338697_88338848 0.47 ZNF469
 zinc finger protein 469
 155107
 0.03
chr6_12718315_12718575 0.46 PHACTR1
 phosphatase and actin regulator 1
 97
 0.98
chr10_15760270_15760566 0.46 ITGA8
 integrin, alpha 8
 1706
 0.51
chrX_39377843_39378107 0.46 ENSG00000263730
 .
 142495
 0.05
chr19_30719772_30720177 0.46 AC005597.1
352
 0.63
chr20_10900984_10901135 0.46 RP11-103J8.1
18127
 0.28
chr7_27202641_27202952 0.46 HOXA9
 homeobox A9
 2349
 0.09
chr13_99563225_99563376 0.45 DOCK9
 dedicator of cytokinesis 9
 55062
 0.13
chr12_96230499_96230719 0.45 RP11-536G4.2
21967
 0.13
chr8_58908290_58908441 0.45 FAM110B
 family with sequence similarity 110, member B
 1252
 0.65
chr4_16900069_16900243 0.45 LDB2
 LIM domain binding 2
 29
 0.99
chr7_121513447_121513715 0.45 PTPRZ1
 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
 166
 0.97
chr22_46468942_46469448 0.45 RP6-109B7.4
3424
 0.12
chr10_91294704_91295240 0.44 SLC16A12
 solute carrier family 16, member 12
 341
 0.89
chr2_188406887_188407185 0.44 AC007319.1
11840
 0.23
chr8_114449888_114450066 0.44 CSMD3
 CUB and Sushi multiple domains 3
 649
 0.8
chr3_112359324_112359570 0.44 CCDC80
 coiled-coil domain containing 80
 669
 0.77
chr12_24716473_24716754 0.44 ENSG00000240481
 .
 143109
 0.05
chr8_42063953_42065062 0.44 PLAT
 plasminogen activator, tissue
 576
 0.71
chr17_35854577_35854849 0.44 DUSP14
 dual specificity phosphatase 14
 3143
 0.25
chr3_21789745_21789896 0.43 ZNF385D
 zinc finger protein 385D
 3107
 0.38
chr1_231002889_231003524 0.43 C1orf198
 chromosome 1 open reading frame 198
 1193
 0.37
chr1_213226134_213226428 0.43 RPS6KC1
 ribosomal protein S6 kinase, 52kDa, polypeptide 1
 1677
 0.45
chr9_16267652_16267856 0.43 C9orf92
 chromosome 9 open reading frame 92
 8557
 0.32
chr4_62068507_62068658 0.43 LPHN3
 latrophilin 3
 722
 0.82
chr2_166430745_166430996 0.43 CSRNP3
 cysteine-serine-rich nuclear protein 3
 251
 0.96
chr5_88168642_88169029 0.43 MEF2C
 myocyte enhancer factor 2C
 4959
 0.27
chr6_152085356_152085807 0.43 ESR1
 estrogen receptor 1
 39985
 0.18
chr10_120454277_120454428 0.43 CACUL1
 CDK2-associated, cullin domain 1
 60406
 0.11
chr11_133944452_133944603 0.43 JAM3
 junctional adhesion molecule 3
 5561
 0.26
chr8_13369656_13370025 0.43 DLC1
 deleted in liver cancer 1
 2434
 0.32
chr10_77229198_77229525 0.43 RP11-399K21.10
38015
 0.16
chr17_25785381_25785532 0.42 KSR1
 kinase suppressor of ras 1
 1716
 0.37
chr11_74177997_74178329 0.42 KCNE3
 potassium voltage-gated channel, Isk-related family, member 3
 431
 0.77
chr1_14106721_14106872 0.42 PRDM2
 PR domain containing 2, with ZNF domain
 8575
 0.27
chr20_52534251_52534460 0.42 AC005220.3
22344
 0.24
chr3_36805291_36805678 0.42 DCLK3
 doublecortin-like kinase 3
 24132
 0.23
chr9_124262101_124262557 0.42 ENSG00000240299
 .
 5532
 0.22
chr9_16704056_16704545 0.42 BNC2
 basonuclin 2
 780
 0.71
chr2_210444245_210444440 0.42 MAP2
 microtubule-associated protein 2
 9
 0.99
chr4_113970775_113971222 0.41 ANK2
 ankyrin 2, neuronal
 113
 0.97
chrX_53078746_53079004 0.41 GPR173
 G protein-coupled receptor 173
 410
 0.85
chr15_37390103_37390360 0.41 MEIS2
 Meis homeobox 2
 272
 0.88
chrX_24664424_24664575 0.41 PCYT1B
 phosphate cytidylyltransferase 1, choline, beta
 776
 0.62
chr5_97903857_97904008 0.41 ENSG00000223053
 .
 71003
 0.13
chr13_24132983_24133158 0.41 TNFRSF19
 tumor necrosis factor receptor superfamily, member 19
 11439
 0.29
chr15_65714510_65715080 0.41 IGDCC4
 immunoglobulin superfamily, DCC subclass, member 4
 615
 0.71
chr11_6676307_6676669 0.41 DCHS1
 dachsous cadherin-related 1
 597
 0.56
chr16_29231357_29231508 0.41 RP11-231C14.6
92239
 0.06
chr7_11579827_11580194 0.40 AC004160.4
133428
 0.05
chr3_87030882_87031292 0.40 VGLL3
 vestigial like 3 (Drosophila)
 8765
 0.33
chr2_65041018_65041169 0.40 ENSG00000239891
 .
 3419
 0.23
chr2_178160613_178160764 0.40 RP11-337N6.2
4640
 0.13
chr1_224615016_224615209 0.40 WDR26
 WD repeat domain 26
 6695
 0.2
chr2_33516692_33517051 0.40 LTBP1
 latent transforming growth factor beta binding protein 1
 156
 0.96
chr18_56531608_56531759 0.40 ZNF532
 zinc finger protein 532
 42
 0.98
chr3_106279877_106280028 0.40 ENSG00000200610
 .
 45208
 0.2
chr6_7543759_7543937 0.40 DSP
 desmoplakin
 1998
 0.3
chr8_21494840_21495147 0.40 ENSG00000266630
 .
 87484
 0.09
chr2_105458782_105459564 0.40 LINC01158
 long intergenic non-protein coding RNA 1158
 8738
 0.14
chr11_75276408_75276721 0.40 SERPINH1
 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
 2097
 0.24
chr5_14442202_14442353 0.40 TRIO
 trio Rho guanine nucleotide exchange factor
 46280
 0.19
chr3_71553679_71554070 0.40 ENSG00000221264
 .
 37366
 0.17
chr12_89777470_89777621 0.40 DUSP6
 dual specificity phosphatase 6
 30497
 0.2
chr12_95840276_95840427 0.40 ENSG00000222544
 .
 7732
 0.2
chr5_36607641_36607792 0.39 SLC1A3
 solute carrier family 1 (glial high affinity glutamate transporter), member 3
 564
 0.85
chr12_72665374_72665945 0.39 ENSG00000236333
 .
 112
 0.93
chr3_112355518_112355669 0.39 CCDC80
 coiled-coil domain containing 80
 1351
 0.52
chr6_43742717_43743167 0.39 VEGFA
 vascular endothelial growth factor A
 852
 0.59
chr15_92937732_92938190 0.39 ST8SIA2
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
 666
 0.74

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ZSCAN4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.3 1.0 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.2 0.5 GO:0010842 retina layer formation(GO:0010842)
0.2 0.5 GO:0031223 auditory behavior(GO:0031223)
0.2 1.4 GO:0015732 prostaglandin transport(GO:0015732)
0.2 1.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.4 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.1 0.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.3 GO:1904936 interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.1 0.3 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 1.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 0.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.3 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.3 GO:0008049 male courtship behavior(GO:0008049)
0.1 0.3 GO:0050955 thermoception(GO:0050955)
0.1 0.1 GO:1903224 endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.3 GO:0072070 loop of Henle development(GO:0072070)
0.1 0.4 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.1 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.2 GO:0044557 relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.1 0.6 GO:0045176 apical protein localization(GO:0045176)
0.1 0.2 GO:0060596 mammary placode formation(GO:0060596)
0.1 0.2 GO:0061072 iris morphogenesis(GO:0061072)
0.1 0.3 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.1 0.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 1.7 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.5 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.1 0.5 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 1.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.2 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.1 0.2 GO:0002328 pro-B cell differentiation(GO:0002328)
0.1 0.8 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.1 GO:0060677 ureteric bud elongation(GO:0060677)
0.1 0.4 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.4 GO:0031000 response to caffeine(GO:0031000)
0.1 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0060992 response to fungicide(GO:0060992)
0.1 0.2 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.2 GO:0060976 coronary vasculature development(GO:0060976)
0.1 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.2 GO:0010757 regulation of plasminogen activation(GO:0010755) negative regulation of plasminogen activation(GO:0010757)
0.1 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.2 GO:0008215 spermine metabolic process(GO:0008215)
0.1 1.2 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.1 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0060431 primary lung bud formation(GO:0060431)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.3 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.1 GO:0045634 regulation of melanocyte differentiation(GO:0045634) positive regulation of melanocyte differentiation(GO:0045636) regulation of pigment cell differentiation(GO:0050932) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0 0.2 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.5 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 0.2 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.1 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0072044 collecting duct development(GO:0072044) metanephric collecting duct development(GO:0072205)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.6 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.3 GO:0043266 regulation of potassium ion transport(GO:0043266)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.5 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.1 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.1 GO:0071267 amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 0.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0061001 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:0060484 bronchus development(GO:0060433) lung-associated mesenchyme development(GO:0060484)
0.0 0.1 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0021521 ventral spinal cord interneuron differentiation(GO:0021514) ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.0 0.0 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:1903672 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0019530 taurine metabolic process(GO:0019530)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.0 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.2 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.1 GO:0060287 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.0 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0055057 neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0071674 positive regulation of macrophage chemotaxis(GO:0010759) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.0 0.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0034393 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0055015 ventricular cardiac muscle cell development(GO:0055015)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0046113 nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.0 GO:0061042 vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0 0.5 GO:0051318 G1 phase(GO:0051318)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.0 GO:0043501 skeletal muscle adaptation(GO:0043501)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.0 GO:0090037 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.0 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.1 GO:0006188 IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0 0.0 GO:1902913 positive regulation of neuroepithelial cell differentiation(GO:1902913)
0.0 0.0 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.0 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.1 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.0 GO:0002407 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.2 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.1 GO:1901862 negative regulation of muscle tissue development(GO:1901862)
0.0 0.1 GO:1901863 positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0035058 nonmotile primary cilium assembly(GO:0035058)
0.0 0.0 GO:0010662 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0090303 positive regulation of wound healing(GO:0090303)
0.0 0.1 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.0 GO:0072162 mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0006553 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.0 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0019359 nicotinamide nucleotide biosynthetic process(GO:0019359)
0.0 0.1 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.0 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.0 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.0 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.0 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.2 GO:0001508 action potential(GO:0001508)
0.0 0.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.0 GO:0043620 regulation of DNA-templated transcription in response to stress(GO:0043620)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 0.0 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.0 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.0 0.2 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.1 GO:0048566 embryonic digestive tract development(GO:0048566)
0.0 0.0 GO:0071688 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.0 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.0 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.0 GO:0003341 cilium movement(GO:0003341)
0.0 0.2 GO:0021766 hippocampus development(GO:0021766)
0.0 0.2 GO:0008038 neuron recognition(GO:0008038)
0.0 0.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.0 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.0 GO:0009296 obsolete flagellum assembly(GO:0009296)
0.0 0.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.9 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.8 GO:0043205 fibril(GO:0043205)
0.1 0.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.3 GO:0016600 flotillin complex(GO:0016600)
0.1 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.2 GO:0070852 cell body fiber(GO:0070852)
0.1 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.3 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.0 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.3 GO:0060076 excitatory synapse(GO:0060076)
0.0 0.2 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 3.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.5 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.6 GO:0030426 growth cone(GO:0030426)
0.0 0.2 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.2 0.7 GO:0003680 AT DNA binding(GO:0003680)
0.2 1.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 0.3 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.4 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.1 0.3 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.1 0.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 4.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.7 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.3 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.3 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.3 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.0 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0030553 cGMP binding(GO:0030553)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.0 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.0 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 0.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.9 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 2.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 2.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME S PHASE Genes involved in S Phase
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition