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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Atf4

Z-value: 0.59

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Transcription factors associated with Atf4

Gene Symbol	Gene ID	Gene Info
Atf4 Ensembl NCBI MGI UniProt	ENSMUSG00000042406.7	Atf4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Atf4	chr15_80254231_80254977	580	0.599683	0.37	3.6e-03	Click!
Atf4	chr15_80257273_80257434	1830	0.207522	0.25	5.8e-02	Click!
Atf4	chr15_80257030_80257248	1616	0.232875	0.23	7.3e-02	Click!
Atf4	chr15_80256684_80256930	1284	0.292459	0.19	1.4e-01	Click!
Atf4	chr15_80257680_80258950	2792	0.150338	0.17	1.9e-01	Click!

Activity of the Atf4 motif across conditions

Conditions sorted by the z-value of the Atf4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_32123581_32123732	2.20	5430401H09Rik	RIKEN cDNA 5430401H09 gene	46	0.98
chr14_70625458_70627688	1.97	Dmtn	dematin actin binding protein	418	0.75
chr11_6598568_6599983	1.79	Nacad	NAC alpha domain containing	117	0.92
chr8_121897389_121899362	1.50	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	1873	0.2
chr2_146098449_146098737	1.49	Cfap61	cilia and flagella associated protein 61	51342	0.15
chr17_36866497_36867750	1.34	Trim15	tripartite motif-containing 15	64	0.93
chr11_11687647_11688276	1.23	Ikzf1	IKAROS family zinc finger 1	1516	0.33
chr1_153660970_153662018	1.22	Rgs8	regulator of G-protein signaling 8	413	0.8
chr7_61311164_61311772	1.16	A230006K03Rik	RIKEN cDNA A230006K03 gene	245	0.96
chr7_61159018_61159292	1.11	Gm38451	predicted gene, 38451	28471	0.24
chr12_111442182_111444685	1.10	Tnfaip2	tumor necrosis factor, alpha-induced protein 2	771	0.51
chr19_43985320_43986721	1.04	Cpn1	carboxypeptidase N, polypeptide 1	536	0.73
chr7_61221429_61221953	1.01	A230006K03Rik	RIKEN cDNA A230006K03 gene	90022	0.08
chr2_172393314_172394463	0.99	Cass4	Cas scaffolding protein family member 4	12	0.97
chr1_79437543_79437779	0.98	Scg2	secretogranin II	2381	0.37
chr7_75853296_75853470	0.97	Klhl25	kelch-like 25	4942	0.25
chr2_119350553_119351941	0.94	Chac1	ChaC, cation transport regulator 1	18	0.97
chr1_167383214_167383424	0.92	Mgst3	microsomal glutathione S-transferase 3	10522	0.14
chr10_127511678_127514192	0.91	Ndufa4l2	Ndufa4, mitochondrial complex associated like 2	2032	0.18
chr7_48791267_48791418	0.90	Zdhhc13	zinc finger, DHHC domain containing 13	2310	0.24
chr8_85380167_85381092	0.89	Mylk3	myosin light chain kinase 3	349	0.83
chr15_84324521_84325304	0.89	Parvg	parvin, gamma	117	0.94
chr2_129309240_129309540	0.83	Il1a	interleukin 1 alpha	582	0.59
chr7_16784339_16784989	0.79	Slc1a5	solute carrier family 1 (neutral amino acid transporter), member 5	74	0.95
chr3_108444057_108444211	0.77	Sars	seryl-aminoacyl-tRNA synthetase	1009	0.32
chr17_32117457_32118702	0.77	Gm17276	predicted gene, 17276	4332	0.15
chr12_103388537_103389963	0.76	Otub2	OTU domain, ubiquitin aldehyde binding 2	265	0.84
chr17_31033726_31034632	0.75	Abcg1	ATP binding cassette subfamily G member 1	23496	0.11
chr11_95778707_95778988	0.74	Polr2k-ps	polymerase (RNA) II (DNA directed) polypeptide K, pseudogene	17356	0.11
chr8_70630745_70631808	0.74	Gdf15	growth differentiation factor 15	819	0.39
chr4_117835381_117836667	0.72	Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	586	0.62
chr6_45062685_45062917	0.70	Cntnap2	contactin associated protein-like 2	2740	0.24
chr11_24092672_24093146	0.70	Bcl11a	B cell CLL/lymphoma 11A (zinc finger protein)	12239	0.14
chr15_102150305_102151233	0.69	Soat2	sterol O-acyltransferase 2	243	0.86
chr17_32091482_32092224	0.68	Pdxk-ps	pyridoxal (pyridoxine, vitamin B6) kinase, pseudogene	430	0.78
chr9_96733821_96734335	0.68	Zbtb38	zinc finger and BTB domain containing 38	1308	0.4
chr4_115061778_115062015	0.67	Tal1	T cell acute lymphocytic leukemia 1	2388	0.24
chr8_54956899_54957247	0.66	Gpm6a	glycoprotein m6a	2230	0.24
chr2_69341375_69341619	0.66	Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1103	0.5
chr2_26359770_26360886	0.66	Card9	caspase recruitment domain family, member 9	581	0.52
chr1_195129782_195130181	0.65	Cr1l	complement component (3b/4b) receptor 1-like	519	0.72
chr3_83010068_83011013	0.65	Gm30097	predicted gene, 30097	2052	0.23
chr13_4233789_4234486	0.65	Akr1c19	aldo-keto reductase family 1, member C19	397	0.81
chr7_122672758_122673250	0.65	Cacng3	calcium channel, voltage-dependent, gamma subunit 3	1586	0.39
chr3_57426842_57427133	0.64	Tm4sf4	transmembrane 4 superfamily member 4	1673	0.42
chr2_118554047_118554750	0.64	Bmf	BCL2 modifying factor	4711	0.18
chr13_101691106_101693172	0.63	Pik3r1	phosphoinositide-3-kinase regulatory subunit 1	204	0.95
chr4_108544443_108544594	0.63	Tut4	terminal uridylyl transferase 4	2100	0.17
chr5_124192871_124193356	0.62	Pitpnm2os2	phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 2	1794	0.23
chr1_9745419_9746231	0.61	1700034P13Rik	RIKEN cDNA 1700034P13 gene	1823	0.26
chr3_95950652_95951560	0.59	Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	6902	0.1
chr18_56978049_56978296	0.59	C330018D20Rik	RIKEN cDNA C330018D20 gene	2804	0.3
chr4_19704870_19705084	0.59	Wwp1	WW domain containing E3 ubiquitin protein ligase 1	4016	0.25
chr14_60637402_60638329	0.58	Spata13	spermatogenesis associated 13	3110	0.3
chr12_78904719_78905643	0.58	Plek2	pleckstrin 2	1783	0.34
chr7_78913499_78914279	0.58	Isg20	interferon-stimulated protein	92	0.95
chr11_11962671_11962822	0.58	Grb10	growth factor receptor bound protein 10	6722	0.22
chr4_141073557_141074133	0.57	Necap2	NECAP endocytosis associated 2	140	0.93
chr6_69500271_69500422	0.57	Gm47304	predicted gene, 47304	16135	0.12
chr11_108607827_108608389	0.57	Cep112	centrosomal protein 112	2881	0.32
chr4_132078510_132078882	0.57	Epb41	erythrocyte membrane protein band 4.1	3375	0.14
chr9_44339477_44339803	0.57	Hmbs	hydroxymethylbilane synthase	76	0.9
chr3_59130395_59131019	0.57	P2ry14	purinergic receptor P2Y, G-protein coupled, 14	55	0.97
chr6_149099657_149099981	0.56	Dennd5b	DENN/MADD domain containing 5B	1719	0.23
chr10_11151671_11152032	0.55	Shprh	SNF2 histone linker PHD RING helicase	2327	0.34
chr14_16847192_16847623	0.55	Rarb	retinoic acid receptor, beta	28251	0.23
chr6_144779851_144780433	0.54	Sox5	SRY (sex determining region Y)-box 5	1777	0.35
chr7_109165724_109166870	0.54	Lmo1	LIM domain only 1	4215	0.21
chrX_85616079_85616575	0.53	Gm44378	predicted gene, 44378	27350	0.18
chr15_89322584_89323784	0.53	Adm2	adrenomedullin 2	464	0.63
chr7_126624812_126625701	0.53	Nupr1	nuclear protein transcription regulator 1	88	0.92
chr13_34341882_34342941	0.53	Slc22a23	solute carrier family 22, member 23	1792	0.34
chr5_148398928_148400150	0.53	Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	252	0.94
chr13_91372302_91372553	0.52	Gm29540	predicted gene 29540	1867	0.37
chr14_27430281_27430617	0.52	Tasor	transcription activation suppressor	1615	0.38
chr7_115859202_115859391	0.51	Sox6	SRY (sex determining region Y)-box 6	556	0.85
chr13_19822928_19823079	0.51	Gpr141	G protein-coupled receptor 141	1224	0.45
chr9_71156685_71156836	0.51	Aqp9	aquaporin 9	5873	0.19
chr11_17007546_17008653	0.50	Plek	pleckstrin	603	0.7
chr3_89997986_89998664	0.50	Hax1	HCLS1 associated X-1	37	0.85
chr6_126735053_126735582	0.49	Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	1494	0.38
chr8_94387801_94388063	0.49	Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	333	0.71
chr8_35882704_35883048	0.48	5430403N17Rik	RIKEN cDNA 5430403N17 gene	81	0.97
chr8_121850755_121851753	0.48	Gm26812	predicted gene, 26812	629	0.55
chr13_35755922_35756175	0.48	Cdyl	chromodomain protein, Y chromosome-like	6764	0.19
chr12_116281089_116281240	0.47	Esyt2	extended synaptotagmin-like protein 2	32	0.94
chr6_134927945_134928524	0.47	Lockd	lncRNA downstream of Cdkn1b	858	0.42
chr9_77435194_77435444	0.47	Lrrc1	leucine rich repeat containing 1	6876	0.2
chr14_54417149_54418129	0.46	Slc7a7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	40	0.94
chr18_34778689_34779380	0.46	Kdm3b	KDM3B lysine (K)-specific demethylase 3B	1929	0.22
chr2_65620767_65621991	0.46	Scn2a	sodium channel, voltage-gated, type II, alpha	568	0.82
chr7_135588799_135589009	0.46	Ptpre	protein tyrosine phosphatase, receptor type, E	4484	0.21
chr19_3762115_3762266	0.46	Kmt5b	lysine methyltransferase 5B	5231	0.11
chr2_4572310_4572962	0.46	Frmd4a	FERM domain containing 4A	6460	0.21
chr6_55038035_55039062	0.46	Gars	glycyl-tRNA synthetase	541	0.77
chr8_113551629_113551780	0.46	Gm24291	predicted gene, 24291	23033	0.19
chr6_99191228_99191426	0.45	Foxp1	forkhead box P1	28309	0.24
chr14_60639788_60640342	0.44	Spata13	spermatogenesis associated 13	5310	0.25
chr13_45904596_45904786	0.44	4930453C13Rik	RIKEN cDNA 4930453C13 gene	31349	0.17
chr5_110836247_110836790	0.44	Hscb	HscB iron-sulfur cluster co-chaperone	198	0.9
chr12_72763251_72763786	0.44	Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	2203	0.3
chr17_35000871_35002234	0.44	Vars	valyl-tRNA synthetase	235	0.74
chr12_107994446_107995262	0.44	Bcl11b	B cell leukemia/lymphoma 11B	8560	0.29
chr11_100320488_100321246	0.43	Eif1	eukaryotic translation initiation factor 1	17	0.94
chr4_120856851_120857002	0.43	Rims3	regulating synaptic membrane exocytosis 3	2107	0.21
chr7_111179382_111180585	0.43	1700012D14Rik	RIKEN cDNA 1700012D14 gene	57299	0.11
chr17_88066306_88066664	0.43	Fbxo11	F-box protein 11	1194	0.51
chr12_73779438_73779861	0.42	Gm8075	predicted gene 8075	13834	0.2
chr18_65802028_65802182	0.42	Sec11c	SEC11 homolog C, signal peptidase complex subunit	803	0.51
chr15_86181872_86183211	0.42	Gm15569	predicted gene 15569	3187	0.2
chr6_67034247_67034846	0.41	E230016M11Rik	RIKEN cDNA E230016M11 gene	2053	0.19
chr7_126776991_126777669	0.41	Ypel3	yippee like 3	117	0.78
chr1_37433025_37433308	0.41	Unc50	unc-50 homolog	1822	0.27
chr15_100738581_100738785	0.41	I730030J21Rik	RIKEN cDNA I730030J21 gene	5946	0.13
chr2_91268902_91269542	0.40	Arfgap2	ADP-ribosylation factor GTPase activating protein 2	120	0.94
chr4_140699463_140700390	0.40	Rcc2	regulator of chromosome condensation 2	615	0.61
chr11_20200566_20201086	0.40	Rab1a	RAB1A, member RAS oncogene family	606	0.7
chr7_61030064_61030449	0.40	Gm44643	predicted gene 44643	68871	0.12
chr11_88614518_88614971	0.40	Msi2	musashi RNA-binding protein 2	24597	0.21
chr11_83262776_83263197	0.40	Gm11427	predicted gene 11427	7841	0.09
chr18_69502058_69502470	0.40	Tcf4	transcription factor 4	1306	0.56
chr7_19022230_19023942	0.40	Foxa3	forkhead box A3	452	0.57
chr8_25368281_25369181	0.39	Gm39147	predicted gene, 39147	30289	0.13
chr7_102444287_102444743	0.39	Rrm1	ribonucleotide reductase M1	2472	0.15
chr6_31125380_31126701	0.38	5330406M23Rik	RIKEN cDNA 5330406M23 gene	15120	0.11
chr4_118078652_118079394	0.38	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	47141	0.11
chr4_89485854_89486155	0.38	Gm12608	predicted gene 12608	41360	0.16
chr19_29203241_29203392	0.38	Gm5518	predicted gene 5518	43198	0.11
chr6_120956618_120956869	0.38	Mical3	microtubule associated monooxygenase, calponin and LIM domain containing 3	980	0.41
chr4_43957708_43958633	0.38	Glipr2	GLI pathogenesis-related 2	478	0.74
chr11_24129305_24129928	0.38	Bcl11a	B cell CLL/lymphoma 11A (zinc finger protein)	12763	0.15
chr2_167043825_167044361	0.37	Znfx1	zinc finger, NFX1-type containing 1	598	0.55
chr7_35055557_35056579	0.37	Gm45095	predicted gene 45095	41	0.53
chr10_39369812_39370687	0.37	Fyn	Fyn proto-oncogene	446	0.85
chr12_84204289_84204451	0.37	Gm31513	predicted gene, 31513	8401	0.11
chr5_21056286_21056819	0.37	Ptpn12	protein tyrosine phosphatase, non-receptor type 12	641	0.68
chr9_16437830_16438127	0.37	Gm48726	predicted gene, 48726	2583	0.4
chr10_80331489_80332188	0.37	Reep6	receptor accessory protein 6	1636	0.14
chr15_81802115_81803592	0.37	Tef	thyrotroph embryonic factor	27	0.75
chr5_118482858_118484042	0.37	Gm15754	predicted gene 15754	3517	0.25
chr13_100512536_100512862	0.37	Gtf2h2	general transcription factor II H, polypeptide 2	20120	0.12
chr3_97585683_97585944	0.36	Chd1l	chromodomain helicase DNA binding protein 1-like	18701	0.15
chr7_92887260_92887411	0.36	Prcp	prolylcarboxypeptidase (angiotensinase C)	12035	0.15
chr8_123856422_123856573	0.36	Gm4342	predicted gene 4342	2668	0.13
chr10_58370178_58370662	0.36	Lims1	LIM and senescent cell antigen-like domains 1	1034	0.53
chr13_73476363_73476514	0.36	Lpcat1	lysophosphatidylcholine acyltransferase 1	4687	0.25
chr11_83283019_83283399	0.36	Slfn14	schlafen 14	3517	0.11
chr18_67241729_67242343	0.36	Mppe1	metallophosphoesterase 1	3241	0.19
chr19_10305676_10305827	0.36	Dagla	diacylglycerol lipase, alpha	874	0.53
chr7_61614761_61615352	0.36	B230209E15Rik	RIKEN cDNA B230209E15 gene	271	0.89
chr2_72324313_72324464	0.36	Map3k20	mitogen-activated protein kinase kinase kinase 20	26487	0.16
chr3_91092756_91092907	0.36	S100a7l2	S100 calcium binding protein A7 like 2	2028	0.34
chr5_142650560_142650759	0.36	Wipi2	WD repeat domain, phosphoinositide interacting 2	11855	0.15
chr19_53325039_53326410	0.35	Gm30541	predicted gene, 30541	1	0.97
chr1_189341351_189342108	0.35	Kcnk2	potassium channel, subfamily K, member 2	1626	0.32
chr3_153721362_153721840	0.35	St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	605	0.69
chr3_73051639_73051897	0.35	Slitrk3	SLIT and NTRK-like family, member 3	5175	0.2
chr15_102789128_102789616	0.35	Gm49473	predicted gene, 49473	5999	0.16
chr14_45655772_45656240	0.35	Ddhd1	DDHD domain containing 1	1354	0.28
chr4_123525767_123526146	0.35	Macf1	microtubule-actin crosslinking factor 1	1503	0.44
chr7_6435207_6435948	0.34	Olfr1344	olfactory receptor 1344	3111	0.1
chr10_41209464_41210153	0.34	Gm25526	predicted gene, 25526	6237	0.22
chr4_115839985_115840231	0.34	Mknk1	MAP kinase-interacting serine/threonine kinase 1	848	0.49
chr9_90249400_90250047	0.33	Tbc1d2b	TBC1 domain family, member 2B	6204	0.18
chr9_87021571_87022041	0.33	Cyb5r4	cytochrome b5 reductase 4	208	0.93
chr6_121244244_121244395	0.33	Usp18	ubiquitin specific peptidase 18	1587	0.28
chr9_70543545_70543696	0.32	Sltm	SAFB-like, transcription modulator	722	0.58
chr12_108893486_108894172	0.32	Wdr25	WD repeat domain 25	198	0.57
chr7_4121960_4122900	0.32	Ttyh1	tweety family member 1	281	0.78
chr16_91043345_91044458	0.32	Paxbp1	PAX3 and PAX7 binding protein 1	263	0.76
chr17_25961783_25962611	0.31	Capn15	calpain 15	1563	0.17
chr2_165887152_165887879	0.31	Zmynd8	zinc finger, MYND-type containing 8	2641	0.19
chr8_54954519_54955779	0.31	Gpm6a	glycoprotein m6a	306	0.88
chr6_22025534_22026744	0.31	Cped1	cadherin-like and PC-esterase domain containing 1	196	0.96
chr1_58970537_58971332	0.31	Trak2	trafficking protein, kinesin binding 2	2495	0.2
chr5_96912273_96912506	0.31	Gm43147	predicted gene 43147	852	0.41
chr17_47010961_47011192	0.31	Ubr2	ubiquitin protein ligase E3 component n-recognin 2	520	0.76
chr2_26485135_26488628	0.30	Notch1	notch 1	16383	0.09
chr7_101684127_101684485	0.30	Clpb	ClpB caseinolytic peptidase B	1109	0.51
chr5_112244110_112244261	0.30	Cryba4	crystallin, beta A4	6977	0.12
chrX_134620328_134620674	0.30	Gm7855	predicted gene 7855	5243	0.12
chrX_23281419_23281815	0.30	Klhl13	kelch-like 13	3212	0.36
chr6_3988317_3988783	0.30	Tfpi2	tissue factor pathway inhibitor 2	308	0.88
chr12_5371578_5371994	0.30	Klhl29	kelch-like 29	3896	0.26
chrX_66657509_66657976	0.30	Slitrk2	SLIT and NTRK-like family, member 2	4735	0.2
chr19_61153275_61153617	0.29	Gm22365	predicted gene, 22365	11035	0.12
chr8_122636390_122636583	0.29	Cbfa2t3	CBFA2/RUNX1 translocation partner 3	9980	0.09
chr3_84313220_84313371	0.29	Trim2	tripartite motif-containing 2	6418	0.27
chr13_114531946_114532233	0.29	Gm25950	predicted gene, 25950	48406	0.11
chr1_66386919_66387899	0.29	Map2	microtubule-associated protein 2	398	0.87
chr5_81196201_81196352	0.29	Gm43594	predicted gene 43594	52973	0.17
chr19_44106802_44107431	0.29	Chuk	conserved helix-loop-helix ubiquitous kinase	166	0.92
chr17_53569556_53570941	0.28	Kat2b	K(lysine) acetyltransferase 2B	3277	0.2
chr7_109602204_109602761	0.28	Denn2b	DENN domain containing 2B	183	0.94
chr7_121709089_121709240	0.28	Usp31	ubiquitin specific peptidase 31	1911	0.27
chr15_103252820_103253410	0.28	Nfe2	nuclear factor, erythroid derived 2	37	0.95
chr3_88831100_88832914	0.28	1500004A13Rik	RIKEN cDNA 1500004A13 gene	361	0.77
chr1_178187713_178188786	0.28	Desi2	desumoylating isopeptidase 2	402	0.86
chr3_103172753_103173085	0.28	Bcas2	breast carcinoma amplified sequence 2	1134	0.38
chr11_46077651_46077829	0.28	Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	21682	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.3	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.3	1.8	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.2	0.7	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2	0.5	GO:2000019	negative regulation of male gonad development(GO:2000019)
0.1	0.8	GO:0010815	bradykinin catabolic process(GO:0010815)
0.1	0.4	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.1	0.5	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	1.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.1	0.5	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.1	0.4	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.1	0.8	GO:0015825	L-serine transport(GO:0015825)
0.1	0.3	GO:0048769	sarcomerogenesis(GO:0048769)
0.1	0.3	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.1	0.5	GO:0036233	glycine import(GO:0036233)
0.1	0.4	GO:0015722	canalicular bile acid transport(GO:0015722)
0.1	0.6	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.1	0.2	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1	0.8	GO:0035871	protein K11-linked deubiquitination(GO:0035871)
0.1	0.6	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.1	0.2	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.1	0.4	GO:0000820	regulation of glutamine family amino acid metabolic process(GO:0000820)
0.1	0.6	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.1	0.4	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1	0.3	GO:2000481	positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.1	0.6	GO:0018065	protein-cofactor linkage(GO:0018065)
0.1	0.2	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.1	0.2	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.1	0.2	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	0.2	GO:0046959	habituation(GO:0046959)
0.1	0.1	GO:0035995	detection of muscle stretch(GO:0035995)
0.1	0.2	GO:1903352	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1	0.1	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.1	0.3	GO:2000774	positive regulation of cellular senescence(GO:2000774)
0.1	0.2	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.1	0.2	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1	0.7	GO:0051601	exocyst localization(GO:0051601)
0.1	0.2	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.2	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.1	0.5	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.3	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.1	0.1	GO:0072718	response to cisplatin(GO:0072718)
0.1	0.2	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.1	0.2	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1	0.1	GO:0001969	activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.1	0.2	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.2	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.1	GO:2000832	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0	0.1	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.2	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0042938	dipeptide transport(GO:0042938)
0.0	0.1	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0	0.1	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.2	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.5	GO:2000194	regulation of female gonad development(GO:2000194)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.2	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.9	GO:1903318	negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0	0.2	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.2	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.4	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.0	0.1	GO:0060051	negative regulation of protein glycosylation(GO:0060051)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.2	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0046013	T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0	0.2	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.1	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.0	0.2	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0	0.0	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.0	0.1	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.1	GO:0070836	caveola assembly(GO:0070836)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.2	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.2	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.4	GO:0007549	dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.0	GO:0035087	siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0	0.2	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0	0.1	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0	0.1	GO:0032328	alanine transport(GO:0032328)
0.0	0.2	GO:2000288	positive regulation of myoblast proliferation(GO:2000288)
0.0	0.1	GO:0003011	involuntary skeletal muscle contraction(GO:0003011)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.2	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.4	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.3	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0	0.3	GO:0042730	fibrinolysis(GO:0042730)
0.0	0.1	GO:0002254	kinin cascade(GO:0002254)
0.0	0.3	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.2	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.2	GO:0006677	glycosylceramide metabolic process(GO:0006677)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.0	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0	0.5	GO:0006308	DNA catabolic process(GO:0006308)
0.0	0.1	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.0	1.1	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.0	GO:0009182	purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0	0.3	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.1	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.1	GO:0032055	negative regulation of translation in response to stress(GO:0032055)
0.0	0.1	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.0	0.2	GO:0048671	negative regulation of collateral sprouting(GO:0048671)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.2	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.2	GO:0034643	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.4	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.1	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.2	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0	0.1	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.1	GO:0032819	positive regulation of natural killer cell proliferation(GO:0032819)
0.0	0.2	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.1	GO:0070932	histone H3 deacetylation(GO:0070932)
0.0	0.0	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.0	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.2	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.0	0.3	GO:1901741	regulation of myoblast fusion(GO:1901739) positive regulation of myoblast fusion(GO:1901741)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.2	GO:0016114	terpenoid biosynthetic process(GO:0016114)
0.0	0.0	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.0	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.0	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.1	GO:0061304	retinal blood vessel morphogenesis(GO:0061304)
0.0	0.1	GO:0042136	neurotransmitter biosynthetic process(GO:0042136)
0.0	0.1	GO:1903551	regulation of extracellular exosome assembly(GO:1903551)
0.0	0.1	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:2001168	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	0.0	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.1	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.2	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.0	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0	0.1	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.0	0.0	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0	0.0	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.0	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.0	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.0	GO:0060060	post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0	0.0	GO:0009130	UMP biosynthetic process(GO:0006222) pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.9	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.0	0.0	GO:0051697	protein delipidation(GO:0051697)
0.0	0.1	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:1902219	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.1	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.0	0.4	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.0	0.0	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.3	GO:0042168	heme metabolic process(GO:0042168)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.0	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0071361	cellular response to ethanol(GO:0071361)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0042421	norepinephrine biosynthetic process(GO:0042421)
0.0	0.2	GO:0032958	inositol phosphate biosynthetic process(GO:0032958)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.0	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.5	GO:0031094	platelet dense tubular network(GO:0031094)
0.1	0.3	GO:0097413	Lewy body(GO:0097413)
0.1	0.3	GO:0070552	BRISC complex(GO:0070552)
0.1	0.2	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	0.3	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1	0.2	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.1	0.2	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.1	0.2	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.2	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.5	GO:0044232	organelle membrane contact site(GO:0044232)
0.0	0.2	GO:0035363	histone locus body(GO:0035363)
0.0	1.1	GO:0032809	neuronal cell body membrane(GO:0032809)
0.0	0.2	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.6	GO:0030125	clathrin vesicle coat(GO:0030125)
0.0	0.6	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.5	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.4	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.3	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.3	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.3	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.4	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.1	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.6	GO:0015030	Cajal body(GO:0015030)
0.0	0.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.1	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.1	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0002177	manchette(GO:0002177)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.4	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.2	GO:0043196	varicosity(GO:0043196)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	0.2	GO:0031091	platelet alpha granule(GO:0031091)
0.0	0.1	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0000974	Prp19 complex(GO:0000974)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0005818	aster(GO:0005818)
0.0	0.2	GO:0031430	M band(GO:0031430)
0.0	0.0	GO:0044298	cell body membrane(GO:0044298)
0.0	0.2	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.3	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.0	GO:0000322	storage vacuole(GO:0000322)
0.0	0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.3	GO:0032281	AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.2	0.6	GO:0030620	U2 snRNA binding(GO:0030620)
0.2	0.5	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.7	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.1	0.3	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.5	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.1	0.3	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	0.8	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1	0.3	GO:0008384	IkappaB kinase activity(GO:0008384)
0.1	0.2	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1	0.2	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.1	0.7	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	0.8	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	0.3	GO:0042609	CD4 receptor binding(GO:0042609)
0.1	0.4	GO:0019966	interleukin-1 binding(GO:0019966)
0.1	0.3	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.1	0.2	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.1	0.3	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.1	0.4	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.1	1.0	GO:0005112	Notch binding(GO:0005112)
0.1	0.6	GO:0043176	amine binding(GO:0043176)
0.1	0.2	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	0.4	GO:0050700	CARD domain binding(GO:0050700)
0.1	0.3	GO:0070728	leucine binding(GO:0070728)
0.0	1.5	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	0.2	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.2	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.3	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0035473	lipase binding(GO:0035473)
0.0	0.2	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.2	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.2	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.5	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.9	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.1	GO:0005350	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.2	GO:0103116	alpha-D-galactofuranose transporter activity(GO:0103116)
0.0	0.1	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.0	0.2	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.0	0.1	GO:0030619	U1 snRNA binding(GO:0030619)
0.0	0.6	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.2	GO:0034534	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.4	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.1	GO:0008865	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.0	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.1	GO:0004337	geranyltranstransferase activity(GO:0004337)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.7	GO:0004812	aminoacyl-tRNA ligase activity(GO:0004812)
0.0	0.4	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.7	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.3	GO:0015238	drug transmembrane transporter activity(GO:0015238)
0.0	0.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.3	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.2	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0016936	galactoside binding(GO:0016936)
0.0	0.1	GO:0051021	GDP-dissociation inhibitor binding(GO:0051021)
0.0	0.4	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.0	0.0	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.0	GO:0050145	nucleoside phosphate kinase activity(GO:0050145)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.1	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.1	GO:0009881	photoreceptor activity(GO:0009881)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.6	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.0	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.0	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.2	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0019862	IgA binding(GO:0019862)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.4	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.0	GO:0042910	xenobiotic transporter activity(GO:0042910)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	0.7	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	1.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.8	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.7	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.5	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.4	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	1.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	1.2	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.5	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.5	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.1	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression
0.0	0.5	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.3	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.3	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.5	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.3	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0	0.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.1	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.2	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.5	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.1	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.1	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.0	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling