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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Bhlhe40

Z-value: 0.48

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Transcription factors associated with Bhlhe40

Gene Symbol	Gene ID	Gene Info
Bhlhe40 Ensembl NCBI MGI UniProt	ENSMUSG00000030103.5	Bhlhe40

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Bhlhe40	chr6_108708998_108710182	46544	0.115962	0.49	7.6e-05	Click!
Bhlhe40	chr6_108667829_108669053	5395	0.178193	0.36	4.8e-03	Click!
Bhlhe40	chr6_108659051_108660392	908	0.412971	0.32	1.3e-02	Click!
Bhlhe40	chr6_108700489_108700945	37671	0.130362	0.30	2.1e-02	Click!
Bhlhe40	chr6_108666033_108666205	3073	0.213093	-0.28	2.8e-02	Click!

Activity of the Bhlhe40 motif across conditions

Conditions sorted by the z-value of the Bhlhe40 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_96328165_96328613	0.99	Hoxb3	homeobox B3	327	0.72
chr6_145046367_145046518	0.98	Gm26666	predicted gene, 26666	1117	0.32
chr9_40271177_40271411	0.71	Scn3b	sodium channel, voltage-gated, type III, beta	1607	0.28
chr2_33633273_33633946	0.69	Lmx1b	LIM homeobox transcription factor 1 beta	1326	0.37
chr10_117208235_117208395	0.68	Yeats4	YEATS domain containing 4	9043	0.11
chr8_11729668_11729988	0.67	Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	1651	0.22
chr15_85676712_85677176	0.66	Lncppara	long noncoding RNA near Ppara	23328	0.12
chr12_98215602_98215753	0.65	Galc	galactosylceramidase	851	0.61
chr10_17796356_17797217	0.63	Txlnb	taxilin beta	530	0.7
chr5_138194788_138195306	0.63	Mblac1	metallo-beta-lactamase domain containing 1	733	0.34
chr2_74974235_74975165	0.63	n-R5s198	nuclear encoded rRNA 5S 198	39186	0.14
chr13_48624936_48625515	0.62	Ptpdc1	protein tyrosine phosphatase domain containing 1	284	0.88
chr1_78537079_78538149	0.61	Mogat1	monoacylglycerol O-acyltransferase 1	14	0.97
chr14_19972733_19972884	0.60	Gng2	guanine nucleotide binding protein (G protein), gamma 2	3885	0.26
chr9_77348040_77348200	0.60	Mlip	muscular LMNA-interacting protein	204	0.93
chr13_66867979_66868968	0.60	Cbx3-ps4	chromobox 3, pseudogene 4	3949	0.09
chrX_135210129_135210918	0.59	Tceal6	transcription elongation factor A (SII)-like 6	164	0.93
chr13_65890336_65891205	0.55	Cbx3-ps1	chromobox 3, pseudogene 1	3989	0.13
chr5_104046345_104046782	0.55	Nudt9	nudix (nucleoside diphosphate linked moiety X)-type motif 9	37	0.92
chr12_72844062_72844595	0.54	Gm33785	predicted gene, 33785	26616	0.16
chr7_46399823_46400899	0.53	Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	2713	0.23
chr15_66283828_66283979	0.50	Kcnq3	potassium voltage-gated channel, subfamily Q, member 3	2148	0.3
chr2_101677322_101677473	0.50	Traf6	TNF receptor-associated factor 6	1032	0.53
chr14_123660983_123661518	0.49	Itgbl1	integrin, beta-like 1	174	0.96
chr14_101886064_101886474	0.47	Lmo7	LIM domain only 7	2150	0.43
chr7_29168805_29169490	0.46	Spred3	sprouty-related EVH1 domain containing 3	500	0.5
chr13_83736071_83736534	0.45	Gm33366	predicted gene, 33366	2233	0.18
chr4_34882920_34883280	0.45	Zfp292	zinc finger protein 292	140	0.94
chr12_112653971_112654226	0.45	Akt1	thymoma viral proto-oncogene 1	2875	0.14
chr8_114902581_114902732	0.44	Gm22556	predicted gene, 22556	150257	0.04
chr5_110859375_110859531	0.43	Chek2	checkpoint kinase 2	6818	0.12
chr13_44946654_44947258	0.43	Dtnbp1	dystrobrevin binding protein 1	188	0.96
chr2_65848718_65849208	0.43	Csrnp3	cysteine-serine-rich nuclear protein 3	3108	0.27
chr19_28967063_28967227	0.42	4430402I18Rik	RIKEN cDNA 4430402I18 gene	585	0.61
chr1_178799792_178800387	0.41	Kif26b	kinesin family member 26B	1651	0.46
chr2_65620767_65621991	0.41	Scn2a	sodium channel, voltage-gated, type II, alpha	568	0.82
chr18_82765452_82765786	0.41	2210420H20Rik	RIKEN cDNA 2210420H20 gene	6578	0.12
chr17_29503441_29503611	0.39	Pim1	proviral integration site 1	10119	0.1
chrX_153831936_153833079	0.38	Spin2c	spindlin family, member 2C	214	0.94
chr11_101552879_101553691	0.37	Nbr1	NBR1, autophagy cargo receptor	384	0.68
chr18_73863569_73864469	0.37	Mro	maestro	347	0.9
chr15_25408150_25408416	0.37	Basp1	brain abundant, membrane attached signal protein 1	5415	0.17
chr5_67444309_67444915	0.36	Gm20072	predicted gene, 20072	8867	0.13
chr11_96306504_96308444	0.36	Hoxb5os	homeobox B5 and homeobox B6, opposite strand	564	0.48
chr13_65351676_65352548	0.35	Gm7762	predicted gene 7762	3515	0.09
chr16_32645520_32645725	0.35	Tnk2	tyrosine kinase, non-receptor, 2	663	0.63
chr4_76445756_76446479	0.35	Ptprd	protein tyrosine phosphatase, receptor type, D	3863	0.26
chr1_191224508_191225332	0.35	D730003I15Rik	RIKEN cDNA D730003I15 gene	446	0.76
chr11_74833809_74834108	0.34	Mnt	max binding protein	2368	0.2
chr10_103367864_103369217	0.34	Slc6a15	solute carrier family 6 (neurotransmitter transporter), member 15	697	0.75
chr4_140779841_140780227	0.33	Padi4	peptidyl arginine deiminase, type IV	5798	0.14
chr8_33833218_33834143	0.33	Rbpms	RNA binding protein gene with multiple splicing	9991	0.16
chr5_136170674_136171277	0.33	Orai2	ORAI calcium release-activated calcium modulator 2	262	0.85
chr1_87475065_87476008	0.33	Snorc	secondary ossification center associated regulator of chondrocyte maturation	2997	0.17
chr6_143143889_143144415	0.32	Gm44306	predicted gene, 44306	9065	0.14
chr1_40085123_40085879	0.32	Gm16894	predicted gene, 16894	350	0.57
chr13_65420114_65420941	0.32	Cbx3-ps5	chromobox 3, pseudogene 5	3926	0.09
chr6_37442520_37442875	0.32	Creb3l2	cAMP responsive element binding protein 3-like 2	551	0.84
chr13_98012001_98012458	0.32	Arhgef28	Rho guanine nucleotide exchange factor (GEF) 28	4188	0.31
chr11_11461741_11462055	0.31	Spata48	spermatogenesis associated 48	196	0.78
chr6_30572822_30572973	0.31	Gm13781	predicted gene 13781	3138	0.16
chr5_125531759_125532074	0.31	Tmem132b	transmembrane protein 132B	142	0.95
chr6_72097122_72097507	0.30	St3gal5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	278	0.85
chr13_109568819_109569310	0.30	Pde4d	phosphodiesterase 4D, cAMP specific	12341	0.32
chrX_48256907_48257321	0.30	Utp14a	UTP14A small subunit processome component	196	0.93
chrX_38772434_38772699	0.30	6030498E09Rik	RIKEN cDNA 6030498E09 gene	105	0.96
chr3_126596101_126596252	0.30	Camk2d	calcium/calmodulin-dependent protein kinase II, delta	126	0.95
chr2_26586309_26586605	0.30	Egfl7	EGF-like domain 7	173	0.48
chr6_64688339_64689088	0.30	Grid2	glutamate receptor, ionotropic, delta 2	25525	0.22
chr1_24588357_24588596	0.29	Col19a1	collagen, type XIX, alpha 1	1004	0.35
chr1_143739622_143740266	0.29	Glrx2	glutaredoxin 2 (thioltransferase)	298	0.87
chr11_79254808_79254959	0.29	Wsb1	WD repeat and SOCS box-containing 1	212	0.93
chr11_3863976_3864175	0.28	Osbp2	oxysterol binding protein 2	172	0.92
chr13_41355674_41356040	0.28	Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	3390	0.18
chr14_72603037_72603374	0.28	Fndc3a	fibronectin type III domain containing 3A	243	0.94
chr8_91148783_91148985	0.28	Gm45665	predicted gene 45665	3323	0.14
chr8_26258566_26258717	0.28	Gm31727	predicted gene, 31727	8336	0.13
chr5_110102008_110102235	0.27	Plcxd1	phosphatidylinositol-specific phospholipase C, X domain containing 1	917	0.36
chr13_113031709_113032262	0.27	Cdc20b	cell division cycle 20B	3126	0.11
chr11_96436700_96437020	0.27	Gm11529	predicted gene 11529	27687	0.11
chr13_93612831_93613054	0.27	Gm15622	predicted gene 15622	12440	0.16
chr19_14776871_14777022	0.27	Gm26026	predicted gene, 26026	58466	0.15
chr4_118620317_118620501	0.27	Cfap57	cilia and flagella associated protein 57	4	0.85
chr7_101897896_101898047	0.26	Anapc15	anaphase promoting complex C subunit 15	176	0.87
chr16_25425048_25425199	0.26	Gm18896	predicted gene, 18896	18150	0.28
chr8_85025253_85025568	0.26	Asna1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	129	0.86
chr7_60960862_60961355	0.26	Gm44643	predicted gene 44643	277	0.94
chr18_54910548_54911126	0.26	Zfp608	zinc finger protein 608	15275	0.19
chr2_109955255_109955406	0.26	Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	20212	0.18
chr7_127376058_127376333	0.25	Zfp747	zinc finger protein 747	145	0.88
chr15_40169641_40170367	0.25	Gm33301	predicted gene, 33301	7397	0.19
chr1_84709872_84710637	0.25	Dner	delta/notch-like EGF repeat containing	14033	0.15
chr17_25846144_25846295	0.25	Wdr90	WD repeat domain 90	275	0.68
chr14_67608190_67608764	0.25	Gm47010	predicted gene, 47010	19685	0.17
chr18_34572685_34572948	0.25	Nme5	NME/NM23 family member 5	6267	0.14
chr12_108225542_108225693	0.25	Ccnk	cyclin K	26532	0.16
chr9_63131800_63132681	0.24	Gm25064	predicted gene, 25064	1043	0.49
chr17_87609597_87610246	0.24	Epcam	epithelial cell adhesion molecule	26058	0.15
chr8_48224531_48225227	0.24	Gm32842	predicted gene, 32842	46106	0.16
chr9_41950850_41951266	0.24	Sorl1	sortilin-related receptor, LDLR class A repeats-containing	23529	0.17
chr6_34175849_34176966	0.24	Slc35b4	solute carrier family 35, member B4	563	0.73
chr10_81232757_81232928	0.24	Zfr2	zinc finger RNA binding protein 2	313	0.7
chrX_136202895_136204183	0.24	Tceal5	transcription elongation factor A (SII)-like 5	98	0.94
chr12_34221315_34221470	0.24	Gm18025	predicted gene, 18025	69743	0.13
chr18_12168572_12168723	0.24	Rmc1	regulator of MON1-CCZ1	70	0.96
chr2_94246278_94247531	0.23	Mir670hg	MIR670 host gene (non-protein coding)	3566	0.17
chrX_134751410_134751672	0.23	Armcx6	armadillo repeat containing, X-linked 6	124	0.92
chr7_47050631_47051464	0.23	Tmem86a	transmembrane protein 86A	446	0.55
chr10_41519256_41519430	0.23	Cd164	CD164 antigen	71	0.95
chr16_90709814_90710620	0.23	Mis18a	MIS18 kinetochore protein A	16922	0.13
chr13_85189150_85189414	0.23	Ccnh	cyclin H	126	0.97
chr5_123603471_123603893	0.23	Clip1	CAP-GLY domain containing linker protein 1	37	0.96
chr4_128654395_128654699	0.23	Phc2	polyhomeotic 2	155	0.95
chr2_102448665_102449240	0.23	Fjx1	four jointed box 1	3547	0.29
chr9_89622321_89623623	0.22	Minar1	membrane integral NOTCH2 associated receptor 1	153	0.95
chr19_57473261_57473746	0.22	Trub1	TruB pseudouridine (psi) synthase family member 1	20546	0.13
chrX_152326681_152327476	0.22	Kantr	Kdm5c adjacent non-coding transcript	385	0.81
chr1_42918173_42918786	0.22	Mrps9	mitochondrial ribosomal protein S9	15422	0.18
chr1_183296448_183297298	0.21	Brox	BRO1 domain and CAAX motif containing	119	0.58
chr2_74670628_74670804	0.21	Hoxd13	homeobox D13	2406	0.09
chr14_105565805_105566636	0.21	9330188P03Rik	RIKEN cDNA 9330188P03 gene	23256	0.16
chr11_76409000_76409151	0.21	Timm22	translocase of inner mitochondrial membrane 22	1870	0.32
chr11_70240091_70240373	0.21	Rnasek	ribonuclease, RNase K	390	0.4
chr6_115837782_115838472	0.20	Efcab12	EF-hand calcium binding domain 12	285	0.81
chr17_28517451_28518182	0.20	Fkbp5	FK506 binding protein 5	289	0.75
chr14_57746100_57746612	0.20	Lats2	large tumor suppressor 2	222	0.52
chr19_33761196_33761926	0.20	Lipo3	lipase, member O3	390	0.81
chr8_93627469_93627620	0.20	Gm45708	predicted gene 45708	1080	0.55
chr8_85024515_85025244	0.20	Asna1	arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)	11	0.92
chr14_54962885_54964094	0.20	Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	3085	0.08
chr19_17136519_17137673	0.20	Prune2	prune homolog 2	321	0.93
chr16_16557820_16558051	0.20	Fgd4	FYVE, RhoGEF and PH domain containing 4	2055	0.32
chr16_4211315_4211466	0.20	Crebbp	CREB binding protein	2023	0.29
chr3_130730536_130730827	0.20	Gm42997	predicted gene 42997	80	0.75
chr13_91223440_91223964	0.20	Atg10	autophagy related 10	257	0.91
chr15_79400689_79401699	0.19	Tmem184b	transmembrane protein 184b	1725	0.23
chr8_31089411_31091663	0.19	Dusp26	dual specificity phosphatase 26 (putative)	733	0.65
chr5_113082923_113083179	0.19	Crybb3	crystallin, beta B3	1467	0.26
chr6_113341831_113342352	0.19	Camk1	calcium/calmodulin-dependent protein kinase I	1174	0.25
chr1_74376916_74377067	0.19	Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	334	0.78
chr19_33589497_33590410	0.19	AC141640.1	renalase, FAD-dependent amine oxidase (Rnls) pseudogene	54	0.82
chr8_77717432_77717888	0.19	4933431K23Rik	RIKEN cDNA 4933431K23 gene	5924	0.19
chr5_66336775_66338292	0.19	Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	50	0.96
chr6_145855324_145856436	0.19	Gm43909	predicted gene, 43909	7417	0.17
chr2_142218264_142218415	0.19	Macrod2	mono-ADP ribosylhydrolase 2	41732	0.22
chr18_76542618_76543294	0.19	Gm31933	predicted gene, 31933	89914	0.09
chr12_3960025_3960885	0.19	Pomc	pro-opiomelanocortin-alpha	5485	0.16
chr11_96382654_96382805	0.19	Gm11531	predicted gene 11531	9383	0.1
chr2_59162876_59163950	0.19	Pkp4	plakophilin 4	1486	0.38
chr13_112998291_112999283	0.18	Mcidas	multiciliate differentiation and DNA synthesis associated cell cycle protein	4942	0.11
chr1_171033141_171033886	0.18	Gm26110	predicted gene, 26110	5548	0.1
chr2_91068688_91068939	0.18	Slc39a13	solute carrier family 39 (metal ion transporter), member 13	58	0.95
chr10_86685258_86685514	0.18	1810014B01Rik	RIKEN cDNA 1810014B01 gene	139	0.89
chr17_66235333_66235831	0.18	Gm49932	predicted gene, 49932	637	0.64
chr10_22731525_22732100	0.18	Tbpl1	TATA box binding protein-like 1	126	0.86
chr5_113745200_113745351	0.18	Sart3	squamous cell carcinoma antigen recognized by T cells 3	320	0.82
chr8_48740124_48740996	0.18	Tenm3	teneurin transmembrane protein 3	65870	0.13
chr7_16311054_16311205	0.18	Bbc3	BCL2 binding component 3	674	0.57
chr9_91365715_91366080	0.18	Zic1	zinc finger protein of the cerebellum 1	87	0.94
chr2_84741934_84742491	0.18	Mir130a	microRNA 130a	1034	0.27
chr10_33904707_33905726	0.18	Rsph4a	radial spoke head 4 homolog A (Chlamydomonas)	105	0.94
chr9_55326354_55326761	0.18	Nrg4	neuregulin 4	192	0.69
chr16_37916134_37917214	0.18	Gpr156	G protein-coupled receptor 156	178	0.94
chr5_134932138_134932360	0.18	Mettl27	methyltransferase like 27	119	0.86
chr6_100206731_100207328	0.17	Rybp	RING1 and YY1 binding protein	26102	0.16
chr11_110379698_110380704	0.17	Map2k6	mitogen-activated protein kinase kinase 6	18921	0.23
chr5_115373428_115373579	0.17	4930401G09Rik	RIKEN cDNA 4930401G09 gene	13380	0.07
chr4_57039496_57040039	0.17	Epb41l4b	erythrocyte membrane protein band 4.1 like 4b	12091	0.21
chr13_51570228_51570409	0.17	Shc3	src homology 2 domain-containing transforming protein C3	831	0.67
chr6_92743458_92743787	0.17	Prickle2	prickle planar cell polarity protein 2	37467	0.18
chr6_127717657_127718130	0.17	Gm42739	predicted gene 42739	45855	0.09
chr10_85829040_85829963	0.17	Pwp1	PWP1 homolog, endonuclein	7	0.75
chr11_70970532_70970985	0.17	Rpain	RPA interacting protein	229	0.78
chr4_80863119_80863395	0.17	Tyrp1	tyrosinase-related protein 1	16669	0.25
chr6_122802291_122802442	0.17	Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	726	0.49
chr6_49214757_49215017	0.17	Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	70	0.97
chr17_70561249_70561849	0.17	Dlgap1	DLG associated protein 1	3	0.99
chr8_11730035_11730943	0.16	Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	2312	0.16
chr14_61037991_61038513	0.16	Gm41168	predicted gene, 41168	292	0.5
chr7_44973695_44975193	0.16	Cpt1c	carnitine palmitoyltransferase 1c	331	0.61
chr11_120240839_120241468	0.16	Bahcc1	BAH domain and coiled-coil containing 1	4454	0.11
chr5_124186580_124187887	0.16	Pitpnm2	phosphatidylinositol transfer protein, membrane-associated 2	51	0.96
chr6_86438708_86439143	0.16	C87436	expressed sequence C87436	198	0.88
chr13_67682587_67683510	0.16	Zfp738	zinc finger protein 738	419	0.69
chr9_27791337_27792219	0.16	Opcml	opioid binding protein/cell adhesion molecule-like	476	0.89
chr5_114090407_114091746	0.16	Svop	SV2 related protein	291	0.84
chr15_68359591_68359932	0.16	Gm20732	predicted gene 20732	3415	0.16
chr1_25825319_25826237	0.16	Adgrb3	adhesion G protein-coupled receptor B3	361	0.71
chr11_53327066_53327217	0.16	Zcchc10	zinc finger, CCHC domain containing 10	259	0.88
chr10_117417525_117417769	0.16	Gm40770	predicted gene, 40770	3743	0.17
chr11_53692143_53692294	0.16	Rad50	RAD50 double strand break repair protein	2782	0.16
chr7_49119940_49120866	0.16	9130015G15Rik	RIKEN cDNA 9130015G15 gene	13873	0.19
chr11_101086944_101087265	0.16	Mlx	MAX-like protein X	173	0.87
chr2_44486358_44486509	0.16	Gm22867	predicted gene, 22867	57498	0.15
chr12_29537800_29538885	0.16	Myt1l	myelin transcription factor 1-like	3120	0.28
chr15_95652829_95653706	0.16	Dbx2	developing brain homeobox 2	2693	0.28
chr4_134701681_134702469	0.16	Man1c1	mannosidase, alpha, class 1C, member 1	1692	0.39
chr10_81722053_81722226	0.16	Zfp433	zinc finger protein 433	656	0.48
chr17_25833142_25833995	0.16	Stub1	STIP1 homology and U-Box containing protein 1	164	0.8
chr6_6577870_6578625	0.15	Sem1	SEM1, 26S proteasome complex subunit	411	0.88

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Bhlhe40

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	0.6	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.1	0.5	GO:0009169	ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1	0.4	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.1	0.4	GO:0060155	platelet dense granule organization(GO:0060155)
0.1	0.3	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.1	0.3	GO:0002930	trabecular meshwork development(GO:0002930)
0.1	0.3	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1	0.2	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.1	0.3	GO:0006551	leucine metabolic process(GO:0006551)
0.1	0.2	GO:0099558	maintenance of synapse structure(GO:0099558)
0.1	0.2	GO:0072092	ureteric bud invasion(GO:0072092)
0.1	0.2	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1	0.2	GO:0046075	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.0	0.1	GO:1901069	guanosine-containing compound catabolic process(GO:1901069)
0.0	0.2	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:1903261	regulation of serine phosphorylation of STAT3 protein(GO:1903261)
0.0	0.2	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.1	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.0	0.5	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.2	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.1	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.0	0.1	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.2	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.2	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.3	GO:1901409	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.3	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.2	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:1902308	regulation of peptidyl-serine dephosphorylation(GO:1902308)
0.0	0.1	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.1	GO:0006624	vacuolar protein processing(GO:0006624)
0.0	0.2	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.1	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0030035	microspike assembly(GO:0030035)
0.0	0.2	GO:1903504	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0	0.1	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.2	GO:0006983	ER overload response(GO:0006983)
0.0	0.3	GO:0002115	store-operated calcium entry(GO:0002115)
0.0	0.1	GO:2000015	regulation of determination of dorsal identity(GO:2000015)
0.0	0.1	GO:1904659	glucose transmembrane transport(GO:1904659)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.1	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.1	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0	0.1	GO:2000224	regulation of testosterone biosynthetic process(GO:2000224)
0.0	0.0	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.1	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.2	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0090135	actin filament branching(GO:0090135)
0.0	0.0	GO:0014741	negative regulation of muscle hypertrophy(GO:0014741)
0.0	0.0	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.0	GO:0021557	oculomotor nerve development(GO:0021557)
0.0	0.0	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.1	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.1	GO:0051256	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0	0.1	GO:0036158	outer dynein arm assembly(GO:0036158)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.0	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.1	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.3	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0021586	pons maturation(GO:0021586)
0.0	0.0	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.0	0.1	GO:2000348	regulation of CD40 signaling pathway(GO:2000348)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.2	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.2	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.0	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.0	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.0	0.0	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.0	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.0	0.1	GO:1902410	mitotic cytokinetic process(GO:1902410)
0.0	0.0	GO:0034770	histone H4-K20 methylation(GO:0034770)
0.0	0.0	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.1	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.0	GO:0072053	renal inner medulla development(GO:0072053)
0.0	0.1	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.4	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.0	GO:0034476	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.1	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.2	GO:0000322	storage vacuole(GO:0000322)
0.0	0.1	GO:0009279	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.2	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.4	GO:0031082	BLOC complex(GO:0031082)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.3	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.2	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.2	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.2	GO:0043194	axon initial segment(GO:0043194)
0.0	0.4	GO:0097440	apical dendrite(GO:0097440)
0.0	0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:1990131	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.0	GO:0072534	perineuronal net(GO:0072534)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.0	GO:0045009	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	0.3	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.0	0.2	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846) diacylglycerol O-acyltransferase activity(GO:0004144)
0.1	0.5	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.2	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0	0.3	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.4	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.2	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.3	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	1.1	GO:0050699	WW domain binding(GO:0050699)
0.0	0.2	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.2	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0070573	metallodipeptidase activity(GO:0070573)
0.0	0.2	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.6	GO:0052831	phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0	0.1	GO:0034511	U3 snoRNA binding(GO:0034511)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.3	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.3	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.0	GO:0005119	smoothened binding(GO:0005119)
0.0	0.0	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.0	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.1	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.1	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.2	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.0	GO:0051373	FATZ binding(GO:0051373)
0.0	0.3	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.3	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1