Project

ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Cbfb

Z-value: 0.34

Motif logo

Transcription factors associated with Cbfb

Gene Symbol	Gene ID	Gene Info
Cbfb Ensembl NCBI MGI UniProt	ENSMUSG00000031885.7	Cbfb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Cbfb	chr8_105169586_105169737	1013	0.332321	-0.41	1.2e-03	Click!
Cbfb	chr8_105170752_105171814	174	0.868766	-0.22	8.5e-02	Click!
Cbfb	chr8_105170135_105170411	401	0.699902	0.19	1.5e-01	Click!

Activity of the Cbfb motif across conditions

Conditions sorted by the z-value of the Cbfb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_32167230_32167769	0.48	Ncoa4	nuclear receptor coactivator 4	1378	0.28
chr11_83065104_83067047	0.32	Slfn2	schlafen 2	963	0.31
chr4_49548394_49548727	0.31	Aldob	aldolase B, fructose-bisphosphate	986	0.46
chr2_32081622_32082932	0.30	Fam78a	family with sequence similarity 78, member A	1506	0.26
chr3_100485235_100486511	0.29	Tent5c	terminal nucleotidyltransferase 5C	3321	0.18
chr6_90619935_90620303	0.28	Slc41a3	solute carrier family 41, member 3	972	0.47
chr2_158145151_158146425	0.27	Tgm2	transglutaminase 2, C polypeptide	578	0.71
chr6_146220162_146220523	0.27	Itpr2	inositol 1,4,5-triphosphate receptor 2	7201	0.26
chr1_87620304_87621692	0.27	Inpp5d	inositol polyphosphate-5-phosphatase D	371	0.85
chr2_27246009_27247328	0.26	Sardh	sarcosine dehydrogenase	180	0.94
chr1_126603873_126604673	0.26	Nckap5	NCK-associated protein 5	111346	0.07
chr11_96928897_96930218	0.25	Prr15l	proline rich 15-like	163	0.89
chr2_180724979_180726144	0.25	Slc17a9	solute carrier family 17, member 9	161	0.92
chr19_20389423_20390852	0.25	Anxa1	annexin A1	514	0.81
chr7_75586786_75587711	0.25	Akap13	A kinase (PRKA) anchor protein 13	22791	0.17
chr8_67948178_67948899	0.25	Psd3	pleckstrin and Sec7 domain containing 3	3341	0.28
chr7_97748648_97749068	0.24	Aqp11	aquaporin 11	10569	0.16
chr18_11058575_11059292	0.24	Gata6	GATA binding protein 6	114	0.97
chrX_6579571_6580274	0.24	Shroom4	shroom family member 4	2636	0.42
chr14_63270328_63271232	0.24	Gata4	GATA binding protein 4	344	0.87
chr3_116860215_116860366	0.23	Frrs1	ferric-chelate reductase 1	723	0.56
chr16_34922552_34923302	0.23	Mylk	myosin, light polypeptide kinase	7415	0.19
chr15_41751298_41752572	0.23	Oxr1	oxidation resistance 1	234	0.95
chr15_5107710_5108629	0.23	Card6	caspase recruitment domain family, member 6	315	0.81
chr8_120292266_120293650	0.23	Gse1	genetic suppressor element 1, coiled-coil protein	64502	0.09
chr16_42907540_42907820	0.23	Zbtb20	zinc finger and BTB domain containing 20	28	0.98
chr2_127369985_127371247	0.23	Adra2b	adrenergic receptor, alpha 2b	7330	0.15
chr7_105953249_105953965	0.23	Gm4070	predicted gene 4070	333	0.86
chr7_106528440_106529206	0.22	Gm8995	predicted gene 8995	17152	0.19
chr8_3353366_3353932	0.22	Arhgef18	rho/rac guanine nucleotide exchange factor (GEF) 18	189	0.95
chr3_102165384_102165916	0.22	Vangl1	VANGL planar cell polarity 1	290	0.87
chr19_5842574_5845856	0.22	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	1044	0.25
chr4_63153559_63154085	0.22	Ambp	alpha 1 microglobulin/bikunin precursor	351	0.86
chr19_25052648_25052861	0.22	Dock8	dedicator of cytokinesis 8	141	0.97
chr7_106214634_106215341	0.21	Gvin1	GTPase, very large interferon inducible 1	323	0.89
chr9_63726302_63726832	0.21	Smad3	SMAD family member 3	14598	0.22
chr6_115990945_115992684	0.21	Plxnd1	plexin D1	3191	0.2
chr7_78914537_78914688	0.21	Isg20	interferon-stimulated protein	283	0.86
chr2_158306583_158307357	0.21	Lbp	lipopolysaccharide binding protein	358	0.8
chr10_7472799_7473709	0.21	Ulbp1	UL16 binding protein 1	87	0.97
chr5_38480596_38480837	0.21	Slc2a9	solute carrier family 2 (facilitated glucose transporter), member 9	410	0.84
chr4_40851422_40852119	0.21	Gm25931	predicted gene, 25931	1368	0.21
chr1_87636946_87637507	0.21	Inpp5d	inositol polyphosphate-5-phosphatase D	15552	0.16
chr9_110709945_110711208	0.21	Ccdc12	coiled-coil domain containing 12	532	0.66
chr6_38341600_38342409	0.20	Zc3hav1	zinc finger CCCH type, antiviral 1	12269	0.13
chr11_79530296_79530704	0.20	Evi2	ecotropic viral integration site 2	59	0.52
chr14_69278101_69278489	0.20	Gm20236	predicted gene, 20236	3845	0.11
chr14_69496349_69496737	0.20	Gm37094	predicted gene, 37094	3847	0.12
chr3_96830126_96830771	0.20	Pdzk1	PDZ domain containing 1	372	0.68
chr11_29647613_29648153	0.20	Gm12092	predicted gene 12092	2374	0.23
chr7_100854551_100855928	0.20	Relt	RELT tumor necrosis factor receptor	190	0.92
chr6_125071043_125072167	0.20	Lpar5	lysophosphatidic acid receptor 5	328	0.72
chr9_66157901_66159171	0.20	Dapk2	death-associated protein kinase 2	301	0.9
chr5_35727461_35727612	0.20	Sh3tc1	SH3 domain and tetratricopeptide repeats 1	1476	0.36
chr3_121547676_121548236	0.19	Slc44a3	solute carrier family 44, member 3	15552	0.16
chr15_78844291_78845201	0.19	Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	2122	0.16
chr18_10532272_10533276	0.19	Gm24894	predicted gene, 24894	18632	0.16
chr13_76581204_76581595	0.19	Mctp1	multiple C2 domains, transmembrane 1	1671	0.42
chr6_48684916_48685953	0.19	Gimap4	GTPase, IMAP family member 4	852	0.34
chr13_59821306_59822207	0.18	Tut7	terminal uridylyl transferase 7	832	0.41
chrX_164421189_164421355	0.18	Piga	phosphatidylinositol glycan anchor biosynthesis, class A	1312	0.41
chr19_21471462_21471819	0.18	Gda	guanine deaminase	948	0.67
chr2_20736484_20738247	0.18	Etl4	enhancer trap locus 4	51	0.98
chr8_13202008_13202379	0.18	2810030D12Rik	RIKEN cDNA 2810030D12 gene	1373	0.23
chr19_53194082_53195694	0.18	Add3	adducin 3 (gamma)	65	0.97
chr5_137569837_137570642	0.18	Tfr2	transferrin receptor 2	370	0.67
chr12_102355566_102356003	0.18	Rin3	Ras and Rab interactor 3	1004	0.59
chr10_40133248_40133524	0.18	Slc16a10	solute carrier family 16 (monocarboxylic acid transporters), member 10	8868	0.14
chr5_107724563_107727169	0.17	Gfi1	growth factor independent 1 transcription repressor	61	0.88
chr17_80564251_80564461	0.17	Cdkl4	cyclin-dependent kinase-like 4	522	0.78
chrX_139611976_139612272	0.17	Rnf128	ring finger protein 128	757	0.7
chr5_114378285_114378463	0.17	Kctd10	potassium channel tetramerisation domain containing 10	2109	0.21
chr5_66114493_66114985	0.17	Rbm47	RNA binding motif protein 47	16548	0.11
chr1_173741340_173741720	0.17	Ifi207	interferon activated gene 207	217	0.9
chr5_123975536_123976239	0.17	Hip1r	huntingtin interacting protein 1 related	2259	0.17
chr18_20552726_20553199	0.17	Tpi-rs10	triosephosphate isomerase related sequence 10	3598	0.2
chr2_148441004_148443557	0.17	Cd93	CD93 antigen	1283	0.41
chr3_30766411_30766610	0.17	Samd7	sterile alpha motif domain containing 7	10288	0.14
chr16_5007275_5008433	0.17	Smim22	small integral membrane protein 22	86	0.85
chr16_34807078_34808442	0.16	Mylk	myosin, light polypeptide kinase	22839	0.23
chr14_53795405_53795967	0.16	Trav12-4	T cell receptor alpha variable 12-4	17083	0.15
chr15_50361344_50361976	0.16	Gm49198	predicted gene, 49198	74762	0.13
chr13_56177742_56178675	0.16	Tifab	TRAF-interacting protein with forkhead-associated domain, family member B	593	0.68
chr8_71558187_71559532	0.16	Tmem221	transmembrane protein 221	12	0.94
chr16_23058440_23059079	0.16	Kng1	kininogen 1	366	0.69
chr11_116615542_116615779	0.16	Rhbdf2	rhomboid 5 homolog 2	8540	0.1
chr2_134825693_134826026	0.16	Gm14036	predicted gene 14036	21910	0.2
chr10_111996341_111997155	0.16	Glipr1	GLI pathogenesis-related 1 (glioma)	516	0.75
chr19_32322600_32322981	0.16	Sgms1	sphingomyelin synthase 1	439	0.87
chr19_34846228_34846905	0.16	Mir107	microRNA 107	25793	0.12
chr13_56151379_56152016	0.16	Macroh2a1	macroH2A.1 histone	15336	0.14
chr4_57914999_57916744	0.16	D630039A03Rik	RIKEN cDNA D630039A03 gene	426	0.84
chr12_116406570_116406928	0.16	Ncapg2	non-SMC condensin II complex, subunit G2	1315	0.32
chr1_58975052_58975575	0.16	Stradb	STE20-related kinase adaptor beta	1791	0.24
chr6_14752485_14752674	0.15	Ppp1r3a	protein phosphatase 1, regulatory subunit 3A	2695	0.42
chr13_84651738_84651962	0.15	Gm26913	predicted gene, 26913	39091	0.22
chr1_156615340_156616247	0.15	Abl2	v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)	130	0.96
chr3_36606072_36606233	0.15	Bbs7	Bardet-Biedl syndrome 7 (human)	7133	0.15
chr4_53513691_53513842	0.15	Slc44a1	solute carrier family 44, member 1	21846	0.2
chr10_78070047_78070198	0.15	Icosl	icos ligand	762	0.53
chr13_19823886_19824322	0.15	Gpr141	G protein-coupled receptor 141	123	0.97
chr6_115984719_115988278	0.15	Plxnd1	plexin D1	8507	0.15
chr2_163507247_163507946	0.15	Hnf4a	hepatic nuclear factor 4, alpha	788	0.49
chr18_56977658_56977824	0.15	C330018D20Rik	RIKEN cDNA C330018D20 gene	2373	0.33
chr12_61093011_61093162	0.15	Gm48301	predicted gene, 48301	102040	0.08
chr4_132794518_132794820	0.15	Themis2	thymocyte selection associated family member 2	1718	0.23
chr16_38376199_38376921	0.15	Popdc2	popeye domain containing 2	4562	0.14
chr2_127364227_127365175	0.15	Adra2b	adrenergic receptor, alpha 2b	1415	0.34
chr9_42034159_42034310	0.15	Gm16214	predicted gene 16214	11619	0.22
chr12_40381138_40381829	0.15	Zfp277	zinc finger protein 277	18599	0.22
chr11_114072204_114072652	0.14	Sdk2	sidekick cell adhesion molecule 2	5382	0.24
chr7_81122958_81123109	0.14	Slc28a1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	8183	0.15
chr2_163694593_163694992	0.14	Pkig	protein kinase inhibitor, gamma	754	0.55
chr16_38350170_38350349	0.14	Cox17	cytochrome c oxidase assembly protein 17, copper chaperone	967	0.41
chr15_73751801_73752472	0.14	Ptp4a3	protein tyrosine phosphatase 4a3	3762	0.2
chr6_99172298_99172685	0.14	Foxp1	forkhead box P1	9473	0.29
chr18_75384437_75388058	0.14	Smad7	SMAD family member 7	11333	0.21
chr2_109277608_109278317	0.14	Mettl15	methyltransferase like 15	318	0.9
chr15_82792748_82793304	0.14	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	1196	0.3
chr9_90237661_90237812	0.14	Gm16200	predicted gene 16200	16111	0.15
chr17_83845850_83847094	0.14	Haao	3-hydroxyanthranilate 3,4-dioxygenase	277	0.9
chr16_23028396_23028918	0.14	Kng2	kininogen 2	352	0.74
chr16_20960637_20961170	0.14	Gm18769	predicted gene, 18769	239	0.91
chr2_172393314_172394463	0.14	Cass4	Cas scaffolding protein family member 4	12	0.97
chr4_47294508_47294837	0.14	Col15a1	collagen, type XV, alpha 1	6385	0.24
chr15_95838442_95838593	0.14	Gm17546	predicted gene, 17546	8445	0.15
chr8_104101710_104103631	0.14	Cdh5	cadherin 5	1045	0.43
chr7_133700764_133701966	0.14	Uros	uroporphyrinogen III synthase	1173	0.35
chr14_22020334_22020654	0.14	Lrmda	leucine rich melanocyte differentiation associated	646	0.58
chr9_120116040_120116439	0.14	Slc25a38	solute carrier family 25, member 38	1250	0.23
chr8_13202537_13203450	0.14	2810030D12Rik	RIKEN cDNA 2810030D12 gene	2173	0.16
chr18_35739288_35740804	0.14	Sting1	stimulator of interferon response cGAMP interactor 1	30	0.95
chr1_173739285_173739489	0.14	Ifi207	interferon activated gene 207	2360	0.2
chr4_118435800_118435951	0.14	Cdc20	cell division cycle 20	54	0.95
chr12_85686314_85687645	0.14	Batf	basic leucine zipper transcription factor, ATF-like	310	0.85
chr9_70385312_70385463	0.14	Mir5626	microRNA 5626	20366	0.17
chr8_81012059_81012425	0.13	Gm9725	predicted gene 9725	1334	0.4
chrX_133908388_133909247	0.13	Srpx2	sushi-repeat-containing protein, X-linked 2	369	0.84
chr9_32698632_32699875	0.13	Ets1	E26 avian leukemia oncogene 1, 5' domain	2869	0.25
chr8_84197222_84198671	0.13	Gm26887	predicted gene, 26887	279	0.72
chr13_12330029_12330316	0.13	Actn2	actinin alpha 2	10552	0.17
chr1_130740681_130741391	0.13	Gm28857	predicted gene 28857	291	0.71
chr5_67450455_67450649	0.13	Gm20072	predicted gene, 20072	2927	0.18
chr9_44515217_44515909	0.13	Cxcr5	chemokine (C-X-C motif) receptor 5	10858	0.07
chr7_100465236_100467118	0.13	C2cd3	C2 calcium-dependent domain containing 3	770	0.37
chr5_105409514_105410008	0.13	Gm32051	predicted gene, 32051	394	0.82
chr8_36961780_36962451	0.13	Dlc1	deleted in liver cancer 1	8972	0.19
chr15_81043550_81043974	0.13	Mrtfa	myocardin related transcription factor A	1784	0.27
chr14_79296843_79297470	0.13	Rgcc	regulator of cell cycle	4489	0.19
chr2_84843620_84843993	0.13	Slc43a1	solute carrier family 43, member 1	3181	0.15
chr13_42866202_42867352	0.13	Phactr1	phosphatase and actin regulator 1	57	0.98
chrX_56446273_56446502	0.13	Gm2174	predicted gene 2174	1578	0.27
chr7_19011655_19012657	0.13	Irf2bp1	interferon regulatory factor 2 binding protein 1	8112	0.07
chr3_105892115_105892622	0.13	Adora3	adenosine A3 receptor	12053	0.11
chr5_137631381_137632304	0.13	Lrch4	leucine-rich repeats and calponin homology (CH) domain containing 4	1712	0.13
chr14_75160166_75160317	0.13	Lcp1	lymphocyte cytosolic protein 1	14706	0.15
chr2_35557994_35559313	0.13	Gm13446	predicted gene 13446	49	0.85
chr5_134945425_134947032	0.13	Cldn4	claudin 4	706	0.44
chr15_16315135_16315417	0.13	Gm6479	predicted gene 6479	107323	0.07
chr8_89664040_89664191	0.13	Gm24212	predicted gene, 24212	3189	0.38
chr8_79680146_79681210	0.13	Tpd52-ps	tumor protein D52, pseudogene	128	0.95
chr2_65188482_65188857	0.13	Cobll1	Cobl-like 1	47326	0.14
chr8_120831876_120832383	0.13	Gm26878	predicted gene, 26878	48077	0.12
chr15_58594635_58595816	0.12	Fer1l6	fer-1-like 6 (C. elegans)	43280	0.17
chr8_104104538_104104713	0.12	Gm29682	predicted gene, 29682	1248	0.36
chrX_74427105_74427296	0.12	Ikbkg	inhibitor of kappaB kinase gamma	702	0.45
chr13_51737590_51738068	0.12	Sema4d	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	3066	0.26
chr7_25774402_25774657	0.12	Axl	AXL receptor tyrosine kinase	149	0.91
chr1_182928096_182928648	0.12	Gm37542	predicted gene, 37542	20662	0.18
chr3_96223834_96224156	0.12	H2bc21	H2B clustered histone 21	2876	0.05
chr1_78817332_78818790	0.12	Kcne4	potassium voltage-gated channel, Isk-related subfamily, gene 4	1134	0.48
chr9_113706351_113706642	0.12	Pdcd6ip	programmed cell death 6 interacting protein	1748	0.38
chr4_141076285_141076997	0.12	Necap2	NECAP endocytosis associated 2	1584	0.24
chrX_164373324_164374363	0.12	Vegfd	vascular endothelial growth factor D	465	0.82
chr7_19266084_19266414	0.12	Vasp	vasodilator-stimulated phosphoprotein	297	0.76
chr8_25542987_25545804	0.12	Gm16159	predicted gene 16159	9165	0.11
chr13_100600285_100601357	0.12	Gm24261	predicted gene, 24261	3538	0.14
chr10_120694138_120694963	0.12	4930471E19Rik	RIKEN cDNA 4930471E19 gene	4653	0.17
chr7_145111605_145112276	0.12	Gm45181	predicted gene 45181	51056	0.14
chr4_119894810_119895257	0.12	Hivep3	human immunodeficiency virus type I enhancer binding protein 3	80538	0.1
chr1_161734865_161735433	0.12	Gm15429	predicted pseudogene 15429	7660	0.15
chr9_85323760_85324040	0.12	Tent5a	terminal nucleotidyltransferase 5A	3224	0.2
chr3_68691756_68692227	0.12	Il12a	interleukin 12a	464	0.82
chr3_19650548_19651144	0.12	Trim55	tripartite motif-containing 55	6338	0.16
chr9_24485798_24486436	0.12	Dpy19l1	dpy-19-like 1 (C. elegans)	1797	0.39
chr4_106798811_106800382	0.12	Acot11	acyl-CoA thioesterase 11	194	0.93
chr15_51918413_51918564	0.12	Gm48923	predicted gene, 48923	21401	0.15
chr5_92525035_92525371	0.12	Scarb2	scavenger receptor class B, member 2	18370	0.14
chr9_42461646_42462435	0.12	Tbcel	tubulin folding cofactor E-like	579	0.73
chr18_32556111_32556702	0.12	Gypc	glycophorin C	3574	0.26
chr2_35329508_35329682	0.12	Stom	stomatin	7381	0.14
chr19_38042662_38044080	0.12	Myof	myoferlin	13	0.97
chr12_7980336_7980771	0.12	Apob	apolipoprotein B	2774	0.29
chrX_164141443_164141725	0.12	Ace2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	1106	0.48
chr17_35549775_35550249	0.11	Cdsn	corneodesmosin	2116	0.13
chr18_13122372_13122612	0.11	Gm5240	predicted gene 5240	9069	0.22
chr7_19696242_19697209	0.11	Apoe	apolipoprotein E	906	0.31
chr10_45584015_45584201	0.11	Gm47504	predicted gene, 47504	2889	0.24
chr4_141872806_141873468	0.11	Efhd2	EF hand domain containing 2	1783	0.2
chr11_49076677_49076921	0.11	Ifi47	interferon gamma inducible protein 47	212	0.86

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Cbfb

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.3	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.1	0.2	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.1	0.2	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.1	0.2	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.1	0.2	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.1	0.2	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.2	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.2	GO:0060264	regulation of respiratory burst involved in inflammatory response(GO:0060264)
0.0	0.1	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.2	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.3	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.1	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.1	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.0	0.1	GO:0015879	carnitine transport(GO:0015879)
0.0	0.1	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.0	0.1	GO:0032971	regulation of muscle filament sliding(GO:0032971)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.1	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	0.1	GO:0050904	diapedesis(GO:0050904)
0.0	0.1	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.1	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:0060754	positive regulation of mast cell chemotaxis(GO:0060754)
0.0	0.1	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.1	GO:0035865	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.1	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0	0.2	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.1	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0	0.1	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.0	0.1	GO:0061511	centriole elongation(GO:0061511)
0.0	0.1	GO:0019747	regulation of isoprenoid metabolic process(GO:0019747)
0.0	0.0	GO:0009177	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.1	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.1	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0	0.2	GO:0001771	immunological synapse formation(GO:0001771)
0.0	0.1	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0032910	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.2	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.1	GO:1902996	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:1905049	negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.0	0.1	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:2000860	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0	0.0	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.0	0.1	GO:0061304	retinal blood vessel morphogenesis(GO:0061304)
0.0	0.0	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.1	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.0	GO:0060931	sinoatrial node cell development(GO:0060931)
0.0	0.0	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.0	GO:0060268	negative regulation of respiratory burst(GO:0060268)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.0	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.0	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0	0.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.1	GO:0097418	neurofibrillary tangle(GO:0097418)
0.1	GO:0098651	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.1	GO:0061689	tricellular tight junction(GO:0061689)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	GO:0001891	phagocytic cup(GO:0001891)
0.1	GO:0005861	troponin complex(GO:0005861)
0.2	GO:0031528	microvillus membrane(GO:0031528)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0051425	PTB domain binding(GO:0051425)
0.1	0.2	GO:0030620	U2 snRNA binding(GO:0030620)
0.1	0.2	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	0.2	GO:0019862	IgA binding(GO:0019862)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.2	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.1	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.3	GO:0005542	folic acid binding(GO:0005542)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.1	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.0	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.0	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.3	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.4	PID EPO PATHWAY	EPO signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor