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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Cdc5l

Z-value: 0.68

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Transcription factors associated with Cdc5l

Gene Symbol	Gene ID	Gene Info
Cdc5l Ensembl NCBI MGI UniProt	ENSMUSG00000023932.8	Cdc5l

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Cdc5l	chr17_45432754_45433547	391	0.502152	0.26	4.3e-02	Click!
Cdc5l	chr17_45361990_45362141	53619	0.109625	0.20	1.3e-01	Click!
Cdc5l	chr17_45326704_45326930	88867	0.065954	0.19	1.5e-01	Click!
Cdc5l	chr17_45318616_45318940	96906	0.058838	-0.18	1.8e-01	Click!
Cdc5l	chr17_45317989_45318514	97433	0.058400	-0.17	1.9e-01	Click!

Activity of the Cdc5l motif across conditions

Conditions sorted by the z-value of the Cdc5l motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_41585694_41587243	1.96	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	1301	0.29
chr12_98572639_98572973	1.93	Kcnk10	potassium channel, subfamily K, member 10	1906	0.26
chr4_109343653_109343847	1.81	Eps15	epidermal growth factor receptor pathway substrate 15	497	0.8
chr5_148265188_148266164	1.47	Mtus2	microtubule associated tumor suppressor candidate 2	331	0.91
chr13_102957236_102957434	1.39	Mast4	microtubule associated serine/threonine kinase family member 4	1011	0.69
chr6_64799057_64799968	1.32	Atoh1	atonal bHLH transcription factor 1	70387	0.11
chr12_70828137_70828628	1.27	Frmd6	FERM domain containing 6	2693	0.24
chr12_29527051_29527810	1.23	Myt1l	myelin transcription factor 1-like	954	0.62
chr10_69536775_69537233	1.22	Ank3	ankyrin 3, epithelial	2782	0.32
chr18_23036665_23037864	1.16	Nol4	nucleolar protein 4	1392	0.59
chr8_65036696_65037878	1.15	Apela	apelin receptor early endogenous ligand	49	0.68
chr6_36808050_36808542	1.11	Ptn	pleiotrophin	1883	0.46
chr2_83814030_83814462	0.99	Fam171b	family with sequence similarity 171, member B	1610	0.34
chr19_59460526_59461163	0.91	Emx2	empty spiracles homeobox 2	1325	0.36
chr6_13835523_13837039	0.89	Gpr85	G protein-coupled receptor 85	960	0.59
chr10_62863746_62864710	0.89	Tet1	tet methylcytosine dioxygenase 1	1076	0.37
chr1_25228097_25229399	0.87	Adgrb3	adhesion G protein-coupled receptor B3	78	0.96
chr3_27282892_27283771	0.85	Gm37191	predicted gene, 37191	5271	0.2
chr10_109664804_109665193	0.83	3110043J17Rik	RIKEN cDNA 3110043J17 gene	16219	0.26
chr13_116514424_116515376	0.82	Gm47913	predicted gene, 47913	148636	0.04
chr7_30088185_30088336	0.81	Gm26920	predicted gene, 26920	2150	0.12
chr18_37217058_37218378	0.81	Gm10544	predicted gene 10544	39196	0.08
chrX_136115088_136116396	0.80	5730412P04Rik	RIKEN cDNA 5730412P04 gene	11139	0.12
chr9_3403618_3403975	0.80	Cwf19l2	CWF19-like 2, cell cycle control (S. pombe)	204	0.93
chr18_13968574_13969239	0.78	Zfp521	zinc finger protein 521	2814	0.38
chr6_136171003_136171483	0.77	Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	646	0.69
chr14_52327318_52328620	0.76	Sall2	spalt like transcription factor 2	793	0.41
chr3_57846307_57846818	0.76	Pfn2	profilin 2	583	0.72
chr19_5797009_5797210	0.76	Malat1	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	157	0.88
chr14_98164357_98165375	0.76	Dach1	dachshund family transcription factor 1	4677	0.28
chr7_3390544_3391386	0.74	Cacng8	calcium channel, voltage-dependent, gamma subunit 8	282	0.73
chr18_60925301_60926809	0.74	Camk2a	calcium/calmodulin-dependent protein kinase II alpha	330	0.84
chr2_63182035_63182719	0.74	Kcnh7	potassium voltage-gated channel, subfamily H (eag-related), member 7	1793	0.52
chr11_108926426_108927821	0.73	Axin2	axin 2	3942	0.24
chr8_8656555_8657725	0.73	Efnb2	ephrin B2	4099	0.11
chr2_105370584_105371218	0.72	Rcn1	reticulocalbin 1	24447	0.22
chr18_70140801_70141850	0.72	Rab27b	RAB27B, member RAS oncogene family	249	0.95
chr12_27340607_27340913	0.70	Sox11	SRY (sex determining region Y)-box 11	1814	0.48
chr17_10309899_10310075	0.70	Qk	quaking	9374	0.24
chr1_66323360_66324079	0.69	Map2	microtubule-associated protein 2	1617	0.37
chr1_20893244_20893592	0.68	Paqr8	progestin and adipoQ receptor family member VIII	2812	0.17
chr3_84952327_84953098	0.66	Fbxw7	F-box and WD-40 domain protein 7	566	0.84
chr1_168430152_168430657	0.66	Pbx1	pre B cell leukemia homeobox 1	1100	0.61
chr13_45389099_45389552	0.65	Mylip	myosin regulatory light chain interacting protein	417	0.87
chr14_58618020_58618171	0.64	Gm25614	predicted gene, 25614	32305	0.23
chr3_154570067_154570517	0.64	Tyw3	tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)	24242	0.18
chr16_63860769_63861945	0.64	Epha3	Eph receptor A3	2056	0.46
chrX_69362591_69363214	0.64	Gm14705	predicted gene 14705	1633	0.4
chr3_152264342_152264493	0.63	Nexn	nexilin	911	0.47
chr13_78181011_78182180	0.62	Gm38604	predicted gene, 38604	1564	0.29
chr6_33250271_33250473	0.61	Exoc4	exocyst complex component 4	1236	0.47
chr19_19108280_19109261	0.61	Rorb	RAR-related orphan receptor beta	2426	0.42
chr1_106174865_106175693	0.60	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	3527	0.22
chr7_48847211_48847926	0.60	Csrp3	cysteine and glycine-rich protein 3	465	0.76
chr18_82825279_82826286	0.58	4930445N18Rik	RIKEN cDNA 4930445N18 gene	30112	0.12
chr12_26533196_26533974	0.58	Gm46344	predicted gene, 46344	46794	0.11
chr10_88603199_88603736	0.58	Gm48752	predicted gene, 48752	995	0.39
chr6_142506733_142508000	0.58	Ldhb	lactate dehydrogenase B	439	0.83
chr16_44553746_44555096	0.57	Mir3081	microRNA 3081	3708	0.24
chr9_61375691_61376224	0.57	Tle3	transducin-like enhancer of split 3	428	0.83
chr11_77486623_77487566	0.56	Ankrd13b	ankyrin repeat domain 13b	2572	0.17
chr12_3370750_3371679	0.56	Gm48511	predicted gene, 48511	2785	0.18
chr4_126779227_126779591	0.56	Gm12937	predicted gene 12937	17006	0.12
chr4_82496866_82497618	0.56	Nfib	nuclear factor I/B	2074	0.34
chr3_74982117_74982268	0.55	Gm37464	predicted gene, 37464	42423	0.2
chr14_76420544_76421824	0.54	Tsc22d1	TSC22 domain family, member 1	2356	0.39
chr9_21616943_21617223	0.54	Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	819	0.44
chr10_87491430_87491970	0.53	Ascl1	achaete-scute family bHLH transcription factor 1	1960	0.34
chr3_9346361_9346885	0.53	C030034L19Rik	RIKEN cDNA C030034L19 gene	56441	0.13
chr3_61366040_61366196	0.53	B430305J03Rik	RIKEN cDNA B430305J03 gene	167	0.94
chr14_54617129_54617280	0.53	Mir686	microRNA 686	419	0.53
chr9_60686646_60686797	0.52	Lrrc49	leucine rich repeat containing 49	813	0.64
chr15_87545474_87545628	0.52	Tafa5	TAFA chemokine like family member 5	1252	0.64
chr11_117873489_117873785	0.52	Tha1	threonine aldolase 1	156	0.9
chr13_83728524_83729044	0.52	C130071C03Rik	RIKEN cDNA C130071C03 gene	678	0.43
chr8_90958597_90958859	0.52	Chd9	chromodomain helicase DNA binding protein 9	3293	0.23
chr12_86647308_86647551	0.51	Gm8504	predicted gene 8504	3144	0.21
chr10_61625131_61626356	0.51	Gm28447	predicted gene 28447	14669	0.12
chr12_59129648_59129986	0.51	Mia2	MIA SH3 domain ER export factor 2	7	0.97
chr4_6987725_6988203	0.50	Tox	thymocyte selection-associated high mobility group box	2519	0.39
chr5_127310557_127310877	0.50	9430087B13Rik	RIKEN cDNA 9430087B13 gene	1700	0.41
chr14_108914298_108914499	0.50	Slitrk1	SLIT and NTRK-like family, member 1	240	0.96
chr13_83987947_83988519	0.49	Gm4241	predicted gene 4241	242	0.93
chr10_122044917_122045222	0.49	Srgap1	SLIT-ROBO Rho GTPase activating protein 1	2239	0.24
chr6_86051805_86052622	0.48	Add2	adducin 2 (beta)	35	0.96
chr6_8352545_8353207	0.48	Gm16055	predicted gene 16055	11260	0.18
chr12_36313868_36315206	0.48	Sostdc1	sclerostin domain containing 1	398	0.82
chr18_43207273_43208441	0.48	Stk32a	serine/threonine kinase 32A	180	0.95
chr19_28009042_28009226	0.47	Rfx3	regulatory factor X, 3 (influences HLA class II expression)	1656	0.37
chr5_49284738_49286021	0.47	Kcnip4	Kv channel interacting protein 4	280	0.92
chr7_125393888_125394149	0.46	Gm30717	predicted gene, 30717	24096	0.14
chr7_37689602_37690278	0.46	4930505M18Rik	RIKEN cDNA 4930505M18 gene	20141	0.2
chr13_28949179_28949330	0.45	Sox4	SRY (sex determining region Y)-box 4	4459	0.24
chr2_56454538_56455175	0.45	Mir195b	microRNA 195b	330955	0.01
chr2_162658795_162659164	0.45	Ptprt	protein tyrosine phosphatase, receptor type, T	2115	0.26
chr2_13175207_13176270	0.45	Gm37780	predicted gene, 37780	12115	0.2
chr3_34562197_34562348	0.45	Sox2ot	SOX2 overlapping transcript (non-protein coding)	1880	0.28
chr1_78192443_78193046	0.45	Pax3	paired box 3	4094	0.27
chr13_67081589_67081868	0.44	Zfp708	zinc finger protein 708	183	0.87
chr11_69561744_69562204	0.44	Efnb3	ephrin B3	1769	0.15
chr1_126737352_126738681	0.44	Nckap5	NCK-associated protein 5	174	0.97
chr7_27553482_27553949	0.44	2310022A10Rik	RIKEN cDNA 2310022A10 gene	429	0.47
chr9_91369028_91370469	0.43	Zic4	zinc finger protein of the cerebellum 4	250	0.86
chr7_16948034_16948663	0.43	Pnmal2	PNMA-like 2	3666	0.11
chr4_124659206_124660160	0.43	Gm2164	predicted gene 2164	2514	0.16
chr13_23544501_23545496	0.43	H3c7	H3 clustered histone 7	946	0.19
chr10_42860045_42861117	0.43	Scml4	Scm polycomb group protein like 4	38	0.96
chr14_19976049_19977076	0.43	Gng2	guanine nucleotide binding protein (G protein), gamma 2	131	0.97
chr1_70725543_70726581	0.42	Vwc2l	von Willebrand factor C domain-containing protein 2-like	139	0.98
chr5_117240468_117241490	0.42	Taok3	TAO kinase 3	519	0.72
chr13_23561344_23562350	0.42	H3c6	H3 clustered histone 6	522	0.41
chr11_34315006_34315399	0.41	Insyn2b	inhibitory synaptic factor family member 2B	380	0.85
chr5_131532921_131534054	0.41	Auts2	autism susceptibility candidate 2	910	0.58
chr7_73394818_73394989	0.41	Rgma	repulsive guidance molecule family member A	3627	0.16
chr11_29189160_29189311	0.41	Ppp4r3b	protein phosphatase 4 regulatory subunit 3B	7952	0.18
chr11_63914512_63915012	0.40	Hs3st3b1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	7528	0.23
chr1_59684563_59684739	0.40	Nop58	NOP58 ribonucleoprotein	320	0.78
chr10_38967267_38967717	0.40	Lama4	laminin, alpha 4	1820	0.42
chr16_41532916_41533606	0.40	Lsamp	limbic system-associated membrane protein	158	0.98
chr7_90886512_90887836	0.40	Gm45159	predicted gene 45159	102	0.88
chr7_46962989_46963387	0.40	Gm19248	predicted gene, 19248	4060	0.1
chr8_121180685_121181292	0.39	5033426O07Rik	RIKEN cDNA 5033426O07 gene	20847	0.15
chr1_23656325_23656702	0.39	Gm28822	predicted gene 28822	81926	0.09
chr13_44841032_44841435	0.39	Jarid2	jumonji, AT rich interactive domain 2	450	0.83
chr11_101628717_101628957	0.39	Rdm1	RAD52 motif 1	448	0.59
chr2_19554051_19554670	0.39	4921504E06Rik	RIKEN cDNA 4921504E06 gene	446	0.82
chr2_28792637_28792998	0.39	Gm13385	predicted gene 13385	752	0.58
chr16_14705845_14706609	0.38	Snai2	snail family zinc finger 2	375	0.9
chr10_77581317_77581531	0.38	Pttg1ip	pituitary tumor-transforming 1 interacting protein	296	0.82
chr7_62407508_62407659	0.38	Mkrn3	makorin, ring finger protein, 3	12556	0.15
chr6_53574522_53574673	0.38	Creb5	cAMP responsive element binding protein 5	1221	0.6
chr8_69715849_69716479	0.38	Zfp869	zinc finger protein 869	290	0.87
chr3_63962500_63962661	0.38	Gm26850	predicted gene, 26850	1053	0.38
chr1_19212595_19213625	0.37	Tfap2b	transcription factor AP-2 beta	769	0.67
chr9_101198368_101199080	0.37	Ppp2r3a	protein phosphatase 2, regulatory subunit B'', alpha	127	0.94
chr14_114837724_114838180	0.37	4930524C18Rik	RIKEN cDNA 4930524C18 gene	5987	0.2
chr9_22259919_22260226	0.37	Gm39307	predicted gene, 39307	30	0.67
chr18_58206427_58207135	0.37	Fbn2	fibrillin 2	3145	0.33
chr7_30165175_30165502	0.37	Zfp146	zinc finger protein 146	4353	0.08
chr5_14025166_14026433	0.37	Sema3e	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	523	0.75
chr3_56179928_56180616	0.37	Nbea	neurobeachin	3429	0.25
chr1_178335228_178335429	0.37	Hnrnpu	heterogeneous nuclear ribonucleoprotein U	782	0.48
chr13_83735558_83735982	0.36	Gm33366	predicted gene, 33366	2765	0.16
chr2_84648361_84648948	0.36	Ctnnd1	catenin (cadherin associated protein), delta 1	117	0.92
chr6_116107038_116107576	0.36	Gm20404	predicted gene 20404	343	0.63
chr2_94184375_94184526	0.36	Gm23630	predicted gene, 23630	320	0.86
chr10_111247804_111248910	0.36	Osbpl8	oxysterol binding protein-like 8	289	0.91
chr8_48740124_48740996	0.36	Tenm3	teneurin transmembrane protein 3	65870	0.13
chrX_75577044_75577513	0.36	Rab39b	RAB39B, member RAS oncogene family	953	0.4
chr6_39874539_39874690	0.36	Tmem178b	transmembrane protein 178B	1543	0.32
chr11_104158142_104158785	0.35	Crhr1	corticotropin releasing hormone receptor 1	25608	0.16
chr5_126768981_126769769	0.35	Gm33347	predicted gene, 33347	42091	0.14
chr9_67428325_67429235	0.35	Tln2	talin 2	23	0.98
chr7_136007847_136008710	0.35	Gm9341	predicted gene 9341	55480	0.13
chr14_84444241_84444671	0.35	Pcdh17	protocadherin 17	893	0.66
chrX_135993531_135994683	0.35	Arxes2	adipocyte-related X-chromosome expressed sequence 2	283	0.88
chr15_79030902_79031405	0.34	Gcat	glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)	252	0.77
chr4_22835212_22836357	0.33	Gm24078	predicted gene, 24078	88653	0.09
chr15_98900276_98900427	0.33	Dhh	desert hedgehog	1811	0.14
chr6_55680133_55680881	0.33	Neurod6	neurogenic differentiation 6	756	0.69
chr2_94246278_94247531	0.33	Mir670hg	MIR670 host gene (non-protein coding)	3566	0.17
chr3_45382505_45382699	0.33	Pcdh10	protocadherin 10	31	0.97
chr6_112880016_112880276	0.33	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	50687	0.11
chr15_85674019_85674170	0.32	Lncppara	long noncoding RNA near Ppara	20478	0.13
chr2_104589693_104589847	0.32	Cstf3	cleavage stimulation factor, 3' pre-RNA, subunit 3	753	0.54
chr3_122462128_122462287	0.32	Gm25153	predicted gene, 25153	2520	0.2
chr5_84414084_84414723	0.32	Epha5	Eph receptor A5	2403	0.37
chr16_13357876_13359918	0.32	Mrtfb	myocardin related transcription factor B	476	0.83
chr6_6857856_6858925	0.31	Gm44094	predicted gene, 44094	2139	0.2
chr9_112118202_112119292	0.31	Mir128-2	microRNA 128-2	36	0.99
chr4_9269280_9270516	0.31	Clvs1	clavesin 1	551	0.81
chr3_144367127_144368131	0.31	Gm43447	predicted gene 43447	47415	0.13
chr13_28811365_28811516	0.31	Gm17528	predicted gene, 17528	15683	0.19
chr18_23038815_23040349	0.31	Nol4	nucleolar protein 4	496	0.88
chr18_10787357_10787713	0.31	Mir133a-1hg	Mir133a-1, Mir1b and Mir1a-2 host gene	1652	0.2
chr3_5225104_5225624	0.31	Zfhx4	zinc finger homeodomain 4	3859	0.22
chr10_18548959_18549110	0.31	Hebp2	heme binding protein 2	2958	0.29
chr12_29534253_29535510	0.30	Gm20208	predicted gene, 20208	10	0.8
chr7_83077268_83077474	0.30	A530021J07Rik	Riken cDNA A530021J07 gene	7010	0.24
chr11_116921808_116922404	0.30	Mgat5b	mannoside acetylglucosaminyltransferase 5, isoenzyme B	3243	0.21
chr2_165599571_165599939	0.30	Gm28163	predicted gene 28163	2032	0.3
chr11_50325927_50326447	0.30	Canx	calnexin	514	0.68
chr18_31442020_31442171	0.30	Gm26658	predicted gene, 26658	1777	0.3
chr16_77645925_77646470	0.30	Mir125b-2	microRNA 125b-2	76	0.58
chr13_48264468_48265300	0.30	A330033J07Rik	RIKEN cDNA A330033J07 gene	2261	0.19
chr12_118926946_118927231	0.30	Abcb5	ATP-binding cassette, sub-family B (MDR/TAP), member 5	2508	0.38
chr4_66025602_66025943	0.29	Gm11484	predicted gene 11484	328077	0.01
chr6_113442321_113442500	0.29	Jagn1	jagunal homolog 1	159	0.85
chr19_38482437_38482889	0.29	Plce1	phospholipase C, epsilon 1	1542	0.46
chr19_28006304_28006455	0.29	Rfx3	regulatory factor X, 3 (influences HLA class II expression)	4411	0.22
chr18_20745187_20746004	0.29	B4galt6	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6	809	0.66
chr6_101198088_101199306	0.29	Gm26911	predicted gene, 26911	39	0.89
chr1_182412012_182412163	0.28	Trp53bp2	transformation related protein 53 binding protein 2	2915	0.19
chr8_92133986_92134310	0.28	Gm45332	predicted gene 45332	24118	0.17
chr17_4907323_4907483	0.28	4930579D07Rik	RIKEN cDNA 4930579D07 gene	14416	0.19
chr19_50676608_50676776	0.28	Gm26629	predicted gene, 26629	714	0.64
chr13_83717521_83718816	0.28	C130071C03Rik	RIKEN cDNA C130071C03 gene	3213	0.17
chr14_64576826_64577138	0.28	Mir124a-1hg	Mir124-1 host gene (non-protein coding)	10349	0.16
chr14_57744536_57744714	0.28	Lats2	large tumor suppressor 2	29	0.96
chr17_24209746_24209897	0.28	Ntn3	netrin 3	290	0.71

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdc5l

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.3	0.8	GO:0099558	maintenance of synapse structure(GO:0099558)
0.2	0.6	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.1	0.5	GO:0060221	retinal rod cell differentiation(GO:0060221)
0.1	0.5	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.1	0.5	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1	0.4	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.1	0.5	GO:0035995	detection of muscle stretch(GO:0035995)
0.1	0.2	GO:0060447	bud outgrowth involved in lung branching(GO:0060447)
0.1	0.4	GO:0007525	somatic muscle development(GO:0007525)
0.1	0.5	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.5	GO:0006566	threonine metabolic process(GO:0006566)
0.1	0.4	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.1	0.5	GO:0060174	limb bud formation(GO:0060174)
0.1	0.7	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.1	0.3	GO:0090310	negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1	0.3	GO:0071672	negative regulation of smooth muscle cell chemotaxis(GO:0071672)
0.1	0.5	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.1	0.4	GO:0072051	juxtaglomerular apparatus development(GO:0072051)
0.1	0.3	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.7	GO:2000288	positive regulation of myoblast proliferation(GO:2000288)
0.1	0.2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.1	1.1	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	0.3	GO:0048254	snoRNA localization(GO:0048254)
0.1	0.5	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.1	0.2	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.1	0.4	GO:0072017	distal tubule development(GO:0072017)
0.1	0.3	GO:0003383	apical constriction(GO:0003383)
0.1	0.2	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.1	0.5	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1	0.3	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.1	0.3	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.1	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.2	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1	0.2	GO:0090240	positive regulation of histone H4 acetylation(GO:0090240)
0.1	0.3	GO:0015074	DNA integration(GO:0015074)
0.1	0.2	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1	0.2	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.1	0.4	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.1	0.2	GO:0021557	oculomotor nerve development(GO:0021557)
0.1	0.2	GO:1905005	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1	0.2	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.1	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:0061043	regulation of vascular wound healing(GO:0061043)
0.0	0.2	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.3	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.0	GO:0016539	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0	0.1	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.3	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.1	GO:1902896	terminal web assembly(GO:1902896)
0.0	0.3	GO:0048341	paraxial mesoderm formation(GO:0048341)
0.0	0.1	GO:1903679	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.2	GO:0032512	regulation of protein phosphatase type 2B activity(GO:0032512)
0.0	0.1	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.1	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.1	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.2	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.2	GO:0071692	protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.0	0.3	GO:0035881	amacrine cell differentiation(GO:0035881)
0.0	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.2	GO:1900084	regulation of peptidyl-tyrosine autophosphorylation(GO:1900084)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.2	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.2	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.5	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.3	GO:0046036	CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0	0.2	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.5	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.4	GO:0035641	locomotory exploration behavior(GO:0035641)
0.0	0.3	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0016103	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0098814	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.1	GO:0071033	nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0	0.1	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.1	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.0	0.2	GO:0035721	intraciliary retrograde transport(GO:0035721)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.2	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.1	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.3	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0	0.1	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.0	GO:0090135	actin filament branching(GO:0090135)
0.0	0.1	GO:0048023	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0	0.0	GO:0072050	S-shaped body morphogenesis(GO:0072050)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.2	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:1903887	motile primary cilium assembly(GO:1903887)
0.0	0.2	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.2	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280)
0.0	0.1	GO:0010520	regulation of reciprocal meiotic recombination(GO:0010520)
0.0	0.1	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.2	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.0	0.3	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.4	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.1	GO:1900113	regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	0.1	GO:1900127	positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0	0.1	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.0	0.1	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.1	GO:1903849	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0	0.2	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading(GO:1900025)
0.0	0.1	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.0	0.2	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.0	GO:1902837	amino acid import into cell(GO:1902837)
0.0	0.1	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.0	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.0	0.3	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0	0.1	GO:1904322	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.3	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.0	0.1	GO:0032324	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.0	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:0061157	mRNA destabilization(GO:0061157)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.0	0.1	GO:0046077	dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.0	0.1	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.0	0.2	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.0	0.1	GO:0010587	miRNA catabolic process(GO:0010587)
0.0	0.0	GO:0061743	motor learning(GO:0061743)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.0	0.0	GO:1903596	regulation of gap junction assembly(GO:1903596) positive regulation of gap junction assembly(GO:1903598)
0.0	0.0	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0	0.1	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.0	GO:0071376	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0	0.1	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0	0.0	GO:1900157	regulation of bone mineralization involved in bone maturation(GO:1900157)
0.0	0.3	GO:1902668	negative regulation of axon guidance(GO:1902668)
0.0	0.0	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0033121	regulation of purine nucleotide catabolic process(GO:0033121)
0.0	0.0	GO:0060166	olfactory pit development(GO:0060166)
0.0	0.0	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.1	GO:0000059	protein import into nucleus, docking(GO:0000059)
0.0	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.0	GO:0051891	positive regulation of cardioblast differentiation(GO:0051891)
0.0	0.0	GO:0021550	medulla oblongata development(GO:0021550)
0.0	0.0	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.1	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:1901970	positive regulation of mitotic sister chromatid separation(GO:1901970)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.0	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	0.0	GO:0071107	response to parathyroid hormone(GO:0071107)
0.0	0.0	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.0	0.2	GO:0035640	exploration behavior(GO:0035640)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.6	GO:1901379	regulation of potassium ion transmembrane transport(GO:1901379)
0.0	0.0	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.1	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.1	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	0.6	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.0	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.2	GO:0015813	L-glutamate transport(GO:0015813)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.0	GO:0071910	determination of liver left/right asymmetry(GO:0071910)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:0032585	multivesicular body membrane(GO:0032585)
0.2	1.4	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.2	1.4	GO:0043083	synaptic cleft(GO:0043083)
0.1	0.3	GO:0030478	actin cap(GO:0030478)
0.1	0.3	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.1	0.4	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	0.2	GO:0005726	perichromatin fibrils(GO:0005726)
0.1	0.2	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.1	0.2	GO:0097441	basilar dendrite(GO:0097441)
0.1	0.3	GO:0005915	zonula adherens(GO:0005915)
0.1	1.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.3	GO:0032584	growth cone membrane(GO:0032584)
0.0	1.1	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.2	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0036396	MIS complex(GO:0036396)
0.0	0.4	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:1990357	terminal web(GO:1990357)
0.0	0.3	GO:0043194	axon initial segment(GO:0043194)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.2	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	1.5	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.1	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	0.3	GO:0071565	nBAF complex(GO:0071565)
0.0	0.2	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.0	GO:1990393	3M complex(GO:1990393)
0.0	0.3	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0071953	elastic fiber(GO:0071953)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.0	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.2	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.1	GO:0000805	X chromosome(GO:0000805)
0.0	0.0	GO:0044393	microspike(GO:0044393)
0.0	0.0	GO:0032437	cuticular plate(GO:0032437)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.3	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.6	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.1	GO:0071556	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.7	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	0.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.2	GO:0005839	proteasome core complex(GO:0005839)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0050816	phosphothreonine binding(GO:0050816)
0.2	0.9	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.2	0.5	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.2	0.5	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2	0.5	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1	0.5	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.1	0.5	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	0.5	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.1	0.3	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.3	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	0.5	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.1	0.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	0.3	GO:0008502	melatonin receptor activity(GO:0008502)
0.1	0.2	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1	0.5	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.2	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.0	0.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.8	GO:0031489	myosin V binding(GO:0031489)
0.0	0.4	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.4	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.2	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.3	GO:0030957	Tat protein binding(GO:0030957)
0.0	1.5	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.3	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.6	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.2	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.5	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.1	GO:0070905	serine binding(GO:0070905)
0.0	0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.0	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.1	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.3	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.2	GO:0043495	protein anchor(GO:0043495)
0.0	0.5	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.2	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.4	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.7	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.1	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.2	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.2	GO:0070034	telomerase RNA binding(GO:0070034)
0.0	0.2	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.4	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.2	GO:0070402	NADPH binding(GO:0070402)
0.0	0.1	GO:0009041	uridylate kinase activity(GO:0009041)
0.0	0.7	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.0	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.6	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.0	GO:0004487	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.0	GO:0070815	procollagen-lysine 5-dioxygenase activity(GO:0008475) peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.3	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.2	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.2	GO:0031402	sodium ion binding(GO:0031402)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.2	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0051185	coenzyme transporter activity(GO:0051185)
0.0	0.2	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.2	GO:0048038	quinone binding(GO:0048038)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.0	GO:0051373	FATZ binding(GO:0051373)
0.0	0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.0	0.0	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.0	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
1.9	PID NOTCH PATHWAY	Notch signaling pathway
0.6	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.8	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.7	PID ERBB4 PATHWAY	ErbB4 signaling events
0.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.4	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.1	0.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.5	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	1.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.0	REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION	Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.7	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.6	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.5	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	1.1	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.5	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.2	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels