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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Clock

Z-value: 0.65

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Transcription factors associated with Clock

Gene Symbol	Gene ID	Gene Info
Clock Ensembl NCBI MGI UniProt	ENSMUSG00000029238.8	circadian locomotor output cycles kaput

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr5_76303673_76304282	Clock	571	0.499670	-0.12	3.6e-01	Click!
chr5_76304304_76305311	Clock	15	0.534725	0.01	9.3e-01	Click!

Activity of the Clock motif across conditions

Conditions sorted by the z-value of the Clock motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_82845042_82846306	1.82	Rffl	ring finger and FYVE like domain containing protein	418	0.75
chr3_96559570_96560186	1.59	Txnip	thioredoxin interacting protein	155	0.87
chr13_5714127_5714791	1.46	Gm35330	predicted gene, 35330	9983	0.27
chr4_154024404_154026596	1.43	Smim1	small integral membrane protein 1	116	0.93
chr8_40863729_40864362	1.40	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	1467	0.34
chr2_32602237_32602961	1.34	St6galnac6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	2873	0.11
chr14_46761470_46761705	1.33	Cdkn3	cyclin-dependent kinase inhibitor 3	992	0.38
chr3_14878521_14878851	1.27	Car2	carbonic anhydrase 2	7587	0.19
chr4_46401911_46402304	1.19	Hemgn	hemogen	2129	0.22
chr5_134913789_134913940	1.11	Cldn13	claudin 13	1662	0.18
chr17_32402450_32402601	1.08	A530088E08Rik	RIKEN cDNA A530088E08 gene	481	0.59
chr16_87705786_87706863	1.05	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	7320	0.23
chr16_33755568_33756608	1.02	Heg1	heart development protein with EGF-like domains 1	435	0.83
chr18_32557788_32558922	1.01	Gypc	glycophorin C	1625	0.41
chr8_120368836_120369597	0.98	Gm22715	predicted gene, 22715	74333	0.08
chr2_90667370_90668252	0.97	Nup160	nucleoporin 160	9404	0.2
chr18_88924372_88924751	0.96	Socs6	suppressor of cytokine signaling 6	2920	0.21
chr9_113990546_113990983	0.95	Fbxl2	F-box and leucine-rich repeat protein 2	740	0.65
chr7_141009744_141010714	0.93	Ifitm3	interferon induced transmembrane protein 3	541	0.54
chr12_98270951_98271119	0.91	Gpr65	G-protein coupled receptor 65	2400	0.21
chr4_102570084_102571297	0.90	Pde4b	phosphodiesterase 4B, cAMP specific	595	0.85
chr6_136809890_136810041	0.83	Gm44364	predicted gene, 44364	1282	0.22
chr10_58674680_58675712	0.83	Edar	ectodysplasin-A receptor	458	0.8
chr10_21668935_21669344	0.82	Gm5420	predicted gene 5420	17272	0.2
chr10_89484249_89484400	0.81	Nr1h4	nuclear receptor subfamily 1, group H, member 4	22325	0.19
chr19_8736753_8736904	0.81	Wdr74	WD repeat domain 74	684	0.3
chr14_66241488_66242199	0.80	Ptk2b	PTK2 protein tyrosine kinase 2 beta	28291	0.16
chr1_60852322_60852473	0.78	Gm38137	predicted gene, 38137	27941	0.11
chr13_55756582_55757242	0.77	4930451E10Rik	RIKEN cDNA 4930451E10 gene	27567	0.1
chrX_8271051_8272966	0.77	Slc38a5	solute carrier family 38, member 5	366	0.82
chr19_46357434_46357942	0.77	Mfsd13a	major facilitator superfamily domain containing 13a	749	0.39
chr16_32707369_32707640	0.75	Gm9556	predicted gene 9556	19162	0.12
chr9_21029266_21030734	0.75	Icam4	intercellular adhesion molecule 4, Landsteiner-Wiener blood group	546	0.46
chr19_32322991_32323275	0.74	Sgms1	sphingomyelin synthase 1	96	0.98
chr18_57085898_57086199	0.73	Gm18739	predicted gene, 18739	31232	0.15
chr9_40765729_40765955	0.70	Gm48293	predicted gene, 48293	3169	0.13
chr7_27447790_27448588	0.68	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	128	0.82
chr2_103483073_103483738	0.63	Cat	catalase	1720	0.36
chr12_53832808_53833508	0.62	1700060O08Rik	RIKEN cDNA 1700060O08 gene	246234	0.02
chr9_108338333_108338531	0.61	Gm37401	predicted gene, 37401	159	0.75
chr12_105026449_105026657	0.60	Gm47650	predicted gene, 47650	1410	0.24
chr1_61402413_61403049	0.59	9530026F06Rik	RIKEN cDNA 9530026F06 gene	24299	0.16
chr13_75709278_75709841	0.59	Ell2	elongation factor RNA polymerase II 2	1848	0.23
chr12_33966605_33968831	0.59	Twist1	twist basic helix-loop-helix transcription factor 1	10047	0.22
chr5_67821909_67822220	0.58	Atp8a1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	6211	0.14
chr7_19675940_19676174	0.58	Apoc2	apolipoprotein C-II	807	0.36
chrX_143824621_143825251	0.58	Capn6	calpain 6	2396	0.29
chr11_101316299_101317280	0.57	Psme3	proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)	188	0.83
chr1_186358273_186358675	0.57	Gm37491	predicted gene, 37491	11159	0.28
chr1_75217955_75219308	0.57	Tuba4a	tubulin, alpha 4A	7	0.92
chr3_85991395_85991798	0.57	Prss48	protease, serine 48	10895	0.12
chr8_33891636_33892433	0.57	Rbpms	RNA binding protein gene with multiple splicing	270	0.91
chr18_56871689_56871916	0.56	Gm18087	predicted gene, 18087	44286	0.14
chr10_127749619_127751660	0.56	Gpr182	G protein-coupled receptor 182	1093	0.28
chr17_14249901_14250892	0.55	Gm34567	predicted gene, 34567	545	0.76
chr13_118718500_118718874	0.55	Gm16263	predicted gene 16263	3291	0.24
chr18_75502739_75503903	0.54	Gm10532	predicted gene 10532	11324	0.26
chr16_8811666_8811841	0.53	1810013L24Rik	RIKEN cDNA 1810013L24 gene	18347	0.15
chr15_37733527_37733723	0.53	Gm49397	predicted gene, 49397	710	0.42
chr3_129331827_129332986	0.53	Enpep	glutamyl aminopeptidase	142	0.95
chr14_20479030_20480298	0.52	Anxa7	annexin A7	244	0.88
chr15_77928261_77928943	0.52	Txn2	thioredoxin 2	366	0.83
chr11_89298118_89300658	0.51	Nog	noggin	2944	0.27
chr2_132943595_132944461	0.51	Fermt1	fermitin family member 1	1601	0.32
chr7_45474996_45475456	0.51	Dhdh	dihydrodiol dehydrogenase (dimeric)	4705	0.06
chr5_119271318_119271616	0.50	n-R5s175	nuclear encoded rRNA 5S 175	25778	0.22
chr11_86586191_86587628	0.49	Vmp1	vacuole membrane protein 1	28	0.97
chr8_84810943_84811513	0.49	Nfix	nuclear factor I/X	10884	0.08
chr7_49522042_49523415	0.49	Nav2	neuron navigator 2	25464	0.21
chr8_105822112_105822566	0.49	Ranbp10	RAN binding protein 10	4866	0.1
chr1_107529306_107529725	0.48	Serpinb10	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10	488	0.8
chr6_120579351_120580579	0.47	Gm44124	predicted gene, 44124	211	0.9
chr6_127151640_127154010	0.47	Ccnd2	cyclin D2	632	0.57
chr14_47747803_47748032	0.47	4930538L07Rik	RIKEN cDNA 4930538L07 gene	9569	0.16
chr11_99016965_99017116	0.46	Gm23451	predicted gene, 23451	112	0.94
chr18_37999322_37999473	0.46	Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	428	0.71
chr1_12875347_12875986	0.46	Sulf1	sulfatase 1	32875	0.18
chr7_120835150_120835405	0.45	Eef2k	eukaryotic elongation factor-2 kinase	7554	0.14
chr2_174110026_174111205	0.45	Npepl1	aminopeptidase-like 1	266	0.91
chr6_5295172_5295334	0.45	Pon2	paraoxonase 2	3077	0.24
chr9_67842828_67843201	0.44	Vps13c	vacuolar protein sorting 13C	2602	0.27
chr6_119194389_119194967	0.44	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	1553	0.37
chr10_75568361_75569309	0.44	Ggt1	gamma-glutamyltransferase 1	161	0.91
chr4_142020367_142020518	0.44	4930455G09Rik	RIKEN cDNA 4930455G09 gene	2544	0.19
chr9_53402629_53402979	0.43	4930550C14Rik	RIKEN cDNA 4930550C14 gene	479	0.73
chr14_27230459_27230927	0.43	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	7346	0.19
chr2_118487225_118487434	0.42	Gm13983	predicted gene 13983	3152	0.2
chr12_35534028_35535328	0.42	Ahr	aryl-hydrocarbon receptor	55	0.76
chr16_44349131_44349726	0.41	Spice1	spindle and centriole associated protein 1	1382	0.45
chr6_120179299_120179618	0.41	Ninj2	ninjurin 2	14365	0.19
chr19_34290165_34291436	0.41	Fas	Fas (TNF receptor superfamily member 6)	118	0.96
chr4_132342884_132343681	0.41	Rcc1	regulator of chromosome condensation 1	2075	0.11
chr4_134759385_134759719	0.41	Ldlrap1	low density lipoprotein receptor adaptor protein 1	8472	0.2
chr5_73629767_73629939	0.41	Lrrc66	leucine rich repeat containing 66	459	0.78
chr17_5406629_5406997	0.40	Gm29050	predicted gene 29050	2692	0.23
chr17_33916771_33917099	0.40	Tapbp	TAP binding protein	749	0.22
chr7_28796055_28797204	0.40	Rinl	Ras and Rab interactor-like	309	0.76
chr10_84550138_84550342	0.40	Platr7	pluripotency associated transcript 7	3098	0.16
chr15_12545486_12545637	0.40	Pdzd2	PDZ domain containing 2	3717	0.23
chr12_105036200_105036351	0.40	Glrx5	glutaredoxin 5	1059	0.33
chr8_117201307_117201734	0.40	Gan	giant axonal neuropathy	43383	0.14
chr8_84701273_84703379	0.38	Lyl1	lymphoblastomic leukemia 1	545	0.59
chr14_30010042_30010685	0.38	Chdh	choline dehydrogenase	1192	0.28
chr17_86437666_86438206	0.38	Prkce	protein kinase C, epsilon	52626	0.14
chr17_29450623_29451950	0.38	Gm36199	predicted gene, 36199	2388	0.19
chr2_163685701_163685852	0.37	Gm16316	predicted gene 16316	6503	0.15
chr3_100480305_100480711	0.37	Tent5c	terminal nucleotidyltransferase 5C	8686	0.14
chr17_88753020_88753753	0.37	Lhcgr	luteinizing hormone/choriogonadotropin receptor	20670	0.21
chr4_119187058_119187758	0.37	Ermap	erythroblast membrane-associated protein	1339	0.24
chr2_157202552_157202949	0.37	Rbl1	RB transcriptional corepressor like 1	1762	0.3
chr3_152198770_152199020	0.36	Dnajb4	DnaJ heat shock protein family (Hsp40) member B4	5050	0.14
chr16_93938522_93938959	0.36	Cldn14	claudin 14	3644	0.18
chr12_17728003_17728647	0.36	Hpcal1	hippocalcin-like 1	99	0.98
chr14_22289728_22289908	0.36	Lrmda	leucine rich melanocyte differentiation associated	20347	0.27
chr18_34409435_34410714	0.36	Pkd2l2	polycystic kidney disease 2-like 2	648	0.7
chr13_51652601_51652752	0.36	Secisbp2	SECIS binding protein 2	879	0.54
chr1_9547698_9548725	0.35	Adhfe1	alcohol dehydrogenase, iron containing, 1	92	0.95
chr12_56695635_56696302	0.35	Pax9	paired box 9	239	0.9
chr5_135151111_135151379	0.35	Tbl2	transducin (beta)-like 2	1473	0.25
chr13_47111734_47112164	0.35	1700026N04Rik	RIKEN cDNA 1700026N04 gene	5530	0.13
chr5_124052007_124052188	0.34	Gm43661	predicted gene 43661	255	0.85
chr11_30998188_30998421	0.34	Gm12102	predicted gene 12102	5594	0.18
chr8_70329770_70331438	0.34	Gdf1	growth differentiation factor 1	787	0.45
chr12_33218601_33218752	0.34	Atxn7l1os1	ataxin 7-like 1, opposite strand 1	10178	0.21
chr1_193509891_193510142	0.34	Mir205hg	Mir205 host gene	158	0.94
chr11_96790204_96790385	0.34	Cbx1	chromobox 1	1045	0.36
chr17_35813042_35813313	0.34	Ier3	immediate early response 3	8507	0.07
chr1_167269734_167270158	0.33	Uck2	uridine-cytidine kinase 2	14655	0.11
chr4_116555353_116555929	0.33	Tmem69	transmembrane protein 69	294	0.81
chr5_125056018_125058841	0.33	Gm42838	predicted gene 42838	412	0.71
chr4_149696192_149696820	0.33	Pik3cd	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	2046	0.23
chr18_37742006_37744626	0.33	Pcdhgb6	protocadherin gamma subfamily B, 6	1222	0.15
chr1_194943562_194943749	0.32	Cd34	CD34 antigen	4660	0.15
chr4_143141947_143142203	0.32	Mir7021	microRNA 7021	5913	0.16
chr11_117962845_117962996	0.32	Socs3	suppressor of cytokine signaling 3	6266	0.15
chr6_4509880_4510830	0.32	Gm43921	predicted gene, 43921	4268	0.17
chr7_126862474_126862872	0.32	Hirip3	HIRA interacting protein 3	192	0.57
chr2_119476817_119477902	0.32	Ino80	INO80 complex subunit	254	0.91
chr14_63164156_63165244	0.32	Fdft1	farnesyl diphosphate farnesyl transferase 1	225	0.91
chr3_93558555_93558706	0.32	S100a10	S100 calcium binding protein A10 (calpactin)	2097	0.21
chr5_76947565_76947716	0.32	Ppat	phosphoribosyl pyrophosphate amidotransferase	3525	0.15
chr18_61661645_61661818	0.32	Carmn	cardiac mesoderm enhancer-associated non-coding RNA	3759	0.13
chr4_21849018_21849173	0.32	Pnisr	PNN interacting serine/arginine-rich	1014	0.55
chr8_109185308_109186079	0.32	D030068K23Rik	RIKEN cDNA D030068K23 gene	64173	0.13
chr13_73499214_73499493	0.31	Lpcat1	lysophosphatidylcholine acyltransferase 1	3508	0.26
chr9_40487712_40488106	0.31	Gm5055	predicted gene 5055	189	0.93
chr5_66079108_66079628	0.31	Rbm47	RNA binding motif protein 47	1616	0.27
chr9_42461646_42462435	0.31	Tbcel	tubulin folding cofactor E-like	579	0.73
chr19_44135200_44135854	0.30	Cwf19l1	CWF19-like 1, cell cycle control (S. pombe)	98	0.95
chr7_98175238_98175752	0.30	Gm16938	predicted gene, 16938	1699	0.27
chr1_40324725_40326229	0.30	Il1rl2	interleukin 1 receptor-like 2	134	0.96
chr4_63561098_63561515	0.30	Tmem268	transmembrane protein 268	946	0.42
chr12_105962892_105963521	0.30	Vrk1	vaccinia related kinase 1	47022	0.13
chr10_125321650_125321801	0.30	Slc16a7	solute carrier family 16 (monocarboxylic acid transporters), member 7	6810	0.24
chr7_49303593_49304723	0.30	Nav2	neuron navigator 2	20	0.98
chr15_77977643_77977952	0.30	Eif3d	eukaryotic translation initiation factor 3, subunit D	6984	0.16
chr10_42940424_42940575	0.30	Scml4	Scm polycomb group protein like 4	618	0.74
chrX_140061291_140062848	0.30	Nup62cl	nucleoporin 62 C-terminal like	224	0.85
chr1_52499555_52500406	0.29	Nab1	Ngfi-A binding protein 1	320	0.85
chr1_129956479_129957256	0.29	Gm37278	predicted gene, 37278	13705	0.22
chr13_21418981_21419424	0.28	Gm50481	predicted gene, 50481	7151	0.07
chr17_46160338_46160791	0.28	Gtpbp2	GTP binding protein 2	468	0.68
chr10_42273694_42273969	0.28	Foxo3	forkhead box O3	2865	0.34
chr10_81319820_81320351	0.27	Cactin	cactin, spliceosome C complex subunit	1018	0.23
chr8_84800470_84800683	0.27	Nfix	nuclear factor I/X	232	0.86
chr11_98788809_98789966	0.27	Msl1	male specific lethal 1	6129	0.1
chr13_104140168_104140319	0.27	Sgtb	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	30414	0.12
chr16_76510697_76511196	0.27	Gm45030	predicted gene 45030	8037	0.24
chr13_28770503_28770945	0.27	Gm17528	predicted gene, 17528	56399	0.12
chr5_21046537_21046688	0.26	Ptpn12	protein tyrosine phosphatase, non-receptor type 12	9113	0.16
chr9_88241670_88242042	0.26	Gm28231	predicted gene 28231	18039	0.16
chr11_69751843_69752104	0.26	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	6250	0.06
chr1_118310232_118310388	0.26	Tsn	translin	73	0.97
chr11_29636734_29637040	0.26	Gm12092	predicted gene 12092	8622	0.14
chr2_132110919_132111093	0.26	Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	442	0.81
chr1_75458926_75459599	0.26	Asic4	acid-sensing (proton-gated) ion channel family member 4	8563	0.08
chr18_35553027_35554317	0.26	Snhg4	small nucleolar RNA host gene 4	234	0.75
chr9_43204942_43206270	0.26	Pou2f3	POU domain, class 2, transcription factor 3	149	0.95
chr5_103972357_103973054	0.26	Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	4621	0.16
chr11_32300067_32300964	0.26	Hbq1a	hemoglobin, theta 1A	446	0.71
chr8_114641600_114641805	0.26	Gm16117	predicted gene 16117	412	0.87
chr13_81931216_81931367	0.26	F830210D05Rik	RIKEN cDNA F830210D05 gene	1604	0.5
chr2_73429039_73429190	0.26	Gm13707	predicted gene 13707	7205	0.14
chr10_9699351_9699551	0.26	Gm6150	predicted gene 6150	14729	0.14
chr16_18875243_18875394	0.25	Mrpl40	mitochondrial ribosomal protein L40	1221	0.32
chr9_57439089_57439658	0.25	Ppcdc	phosphopantothenoylcysteine decarboxylase	718	0.55
chr15_73059820_73059971	0.25	Trappc9	trafficking protein particle complex 9	1150	0.53
chr5_111508721_111509927	0.25	C130026L21Rik	RIKEN cDNA C130026L21 gene	72098	0.08
chr13_6549550_6549952	0.25	Pitrm1	pitrilysin metallepetidase 1	1516	0.42
chr8_47134944_47136227	0.25	E330018M18Rik	RIKEN cDNA E330018M18 gene	66	0.98
chr17_66350075_66350634	0.25	Mtcl1	microtubule crosslinking factor 1	3809	0.22
chr7_144940103_144940440	0.25	Ccnd1	cyclin D1	346	0.83
chr10_107906593_107906899	0.25	Otogl	otogelin-like	5388	0.28
chr7_131777798_131777949	0.25	Gm44547	predicted gene 44547	8706	0.22
chr2_93447410_93447951	0.25	Cd82	CD82 antigen	4999	0.18
chr7_89521949_89522690	0.25	Prss23	protease, serine 23	3771	0.2
chr2_11513131_11513381	0.24	Gm10851	predicted gene 10851	8450	0.14
chr19_25675361_25675512	0.24	Dmrt2	doublesex and mab-3 related transcription factor 2	3025	0.26
chr12_54405042_54405618	0.24	Gm46328	predicted gene, 46328	5154	0.16
chr5_147825420_147826373	0.24	Gm43155	predicted gene 43155	3651	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Clock

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3	0.8	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.2	0.6	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.2	0.5	GO:0046149	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	0.7	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.1	0.4	GO:0021564	vagus nerve development(GO:0021564)
0.1	0.5	GO:0015819	lysine transport(GO:0015819)
0.1	0.3	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.1	0.2	GO:0042938	dipeptide transport(GO:0042938)
0.1	0.3	GO:0040009	regulation of growth rate(GO:0040009)
0.1	0.4	GO:0071455	cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455)
0.1	1.5	GO:0002347	response to tumor cell(GO:0002347)
0.1	0.4	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1	0.3	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.1	0.2	GO:0010915	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.1	0.2	GO:0048859	formation of anatomical boundary(GO:0048859)
0.1	0.6	GO:0015816	glycine transport(GO:0015816)
0.1	0.2	GO:0009174	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1	0.3	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1	0.2	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.1	0.2	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.1	0.2	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.1	0.2	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.2	GO:0021586	pons maturation(GO:0021586)
0.1	0.2	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.1	0.2	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.1	0.5	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0060825	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0	0.1	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.1	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.5	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.2	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.2	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.9	GO:0043171	peptide catabolic process(GO:0043171)
0.0	0.1	GO:0021747	cochlear nucleus development(GO:0021747)
0.0	0.8	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.5	GO:0009992	cellular water homeostasis(GO:0009992)
0.0	0.1	GO:0046103	inosine biosynthetic process(GO:0046103)
0.0	0.2	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.3	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.3	GO:0009650	UV protection(GO:0009650)
0.0	0.1	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.1	GO:0070278	extracellular matrix constituent secretion(GO:0070278)
0.0	0.2	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0002434	immune complex clearance(GO:0002434)
0.0	0.2	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0015744	succinate transport(GO:0015744)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.2	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0009642	response to light intensity(GO:0009642)
0.0	0.2	GO:0032049	cardiolipin biosynthetic process(GO:0032049)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.1	GO:0046544	development of secondary male sexual characteristics(GO:0046544)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.2	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.6	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.2	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.1	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.0	GO:0036301	macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.0	0.3	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.0	GO:2000553	positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.0	0.1	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.0	0.1	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:1901475	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0007290	spermatid nucleus elongation(GO:0007290)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0014719	skeletal muscle satellite cell activation(GO:0014719)
0.0	0.2	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.1	GO:0006677	glycosylceramide metabolic process(GO:0006677)
0.0	0.0	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.1	GO:0036491	regulation of translation in response to endoplasmic reticulum stress(GO:0036490) regulation of translation initiation in response to endoplasmic reticulum stress(GO:0036491) eiF2alpha phosphorylation in response to endoplasmic reticulum stress(GO:0036492)
0.0	0.1	GO:0060763	mammary duct terminal end bud growth(GO:0060763)
0.0	0.1	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.1	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.1	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.1	GO:0019348	dolichol metabolic process(GO:0019348)
0.0	0.0	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.1	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.2	GO:0051546	keratinocyte migration(GO:0051546)
0.0	0.0	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.0	0.2	GO:0071380	cellular response to prostaglandin E stimulus(GO:0071380)
0.0	0.5	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.1	GO:0061055	myotome development(GO:0061055)
0.0	0.2	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.0	GO:0090069	regulation of ribosome biogenesis(GO:0090069)
0.0	0.3	GO:0042481	regulation of odontogenesis(GO:0042481)
0.0	0.1	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.1	GO:0033227	dsRNA transport(GO:0033227)
0.0	0.0	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0	0.1	GO:0060837	blood vessel endothelial cell differentiation(GO:0060837)
0.0	0.0	GO:0033030	negative regulation of neutrophil apoptotic process(GO:0033030)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0019042	viral latency(GO:0019042)
0.0	0.0	GO:1902947	regulation of tau-protein kinase activity(GO:1902947) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.6	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.0	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.2	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.2	GO:0045060	negative thymic T cell selection(GO:0045060)
0.0	0.0	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.2	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:2000665	interleukin-5 secretion(GO:0072603) interleukin-13 secretion(GO:0072611) regulation of interleukin-5 secretion(GO:2000662) regulation of interleukin-13 secretion(GO:2000665)
0.0	0.2	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0034393	positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.0	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.1	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.0	0.3	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.1	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.1	GO:0006490	oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0	0.0	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0001765	membrane raft assembly(GO:0001765)
0.0	0.0	GO:0046083	adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.0	GO:1901859	negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.0	0.0	GO:0002426	immunoglobulin production in mucosal tissue(GO:0002426)
0.0	0.0	GO:0014724	regulation of twitch skeletal muscle contraction(GO:0014724)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.0	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.0	GO:2000510	positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0	0.0	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0014707	branchiomeric skeletal muscle development(GO:0014707)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	0.5	GO:0042583	chromaffin granule(GO:0042583)
0.1	0.4	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.5	GO:0031983	vesicle lumen(GO:0031983)
0.1	0.2	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.1	0.3	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.1	0.2	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.8	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.3	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.2	GO:0097452	GAIT complex(GO:0097452)
0.0	0.1	GO:0097413	Lewy body(GO:0097413)
0.0	0.2	GO:0001939	female pronucleus(GO:0001939)
0.0	0.4	GO:0031011	Ino80 complex(GO:0031011)
0.0	0.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.1	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.0	1.6	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	0.4	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0044299	C-fiber(GO:0044299)
0.0	0.5	GO:0022624	proteasome accessory complex(GO:0022624)
0.0	0.1	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.2	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.2	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.5	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.0	0.2	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.5	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.2	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.2	GO:0097440	apical dendrite(GO:0097440)
0.0	0.6	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0032797	SMN complex(GO:0032797)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.6	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520)
0.0	0.5	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0003840	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.1	0.5	GO:0015189	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1	0.5	GO:0004064	arylesterase activity(GO:0004064)
0.1	0.5	GO:0061133	endopeptidase activator activity(GO:0061133)
0.1	0.6	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.1	0.2	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	0.2	GO:0004096	catalase activity(GO:0004096)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.5	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1	0.2	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.1	0.2	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1	1.0	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1	0.2	GO:0038181	bile acid receptor activity(GO:0038181)
0.1	0.6	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1	0.8	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.3	GO:0018741	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.2	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.3	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.2	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.5	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.2	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.5	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0015141	succinate transmembrane transporter activity(GO:0015141)
0.0	0.2	GO:0097642	calcitonin family receptor activity(GO:0097642)
0.0	0.1	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.8	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.1	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.1	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.5	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.5	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	1.5	GO:0002039	p53 binding(GO:0002039)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.1	GO:0043199	sulfate binding(GO:0043199)
0.0	0.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0	0.1	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.1	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.4	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:1901474	L-histidine transmembrane transporter activity(GO:0005290) azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.3	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.3	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.6	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.0	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.1	GO:0030249	guanylate cyclase regulator activity(GO:0030249)
0.0	0.4	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0	0.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.1	GO:0043995	histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0	0.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.1	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.0	0.0	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.2	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.0	0.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.6	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
1.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.8	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.0	REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	Genes involved in Phospholipase C-mediated cascade
0.0	0.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	1.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.5	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.7	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.6	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.0	REACTOME HEMOSTASIS	Genes involved in Hemostasis
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors

Results for Clock

Z-value: 0.65

Motif logo

Transcription factors associated with Clock

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Clock motif across conditions

Conditions sorted by the z-value of the Clock motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Clock

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: