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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development
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Results for E2f8

Z-value: 0.44

Motif logo

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Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
E2f8
ENSMUSG00000046179.11 E2F transcription factor 8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr7_48881832_48882357E2f84980.5629000.595.8e-07Click!
chr7_48880272_48881025E2f83560.6491350.556.5e-06Click!
chr7_48879180_48879915E2f814570.2628610.505.5e-05Click!
chr7_48881221_48881734E2f81190.5778780.348.2e-03Click!
chr7_48865527_48865678E2f896490.132537-0.264.1e-02Click!

Activity of the E2f8 motif across conditions

Conditions sorted by the z-value of the E2f8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_3398628_3399056 1.15 Samd9l
 sterile alpha motif domain containing 9-like
 730
 0.64
chr12_24708730_24709261 1.08 Rrm2
 ribonucleotide reductase M2
 34
 0.97
chr11_117810234_117810545 0.89 Syngr2
 synaptogyrin 2
 677
 0.33
chr11_98907694_98909099 0.88 Cdc6
 cell division cycle 6
 245
 0.86
chr6_127034730_127034972 0.78 Fgf6
 fibroblast growth factor 6
 19265
 0.11
chr5_17848306_17848609 0.78 Cd36
 CD36 molecule
 1272
 0.61
chr19_6305921_6306134 0.76 Cdc42bpg
 CDC42 binding protein kinase gamma (DMPK-like)
 429
 0.64
chr13_51648729_51649046 0.73 Gm22806
 predicted gene, 22806
 688
 0.62
chr9_100643671_100643909 0.71 Stag1
 stromal antigen 1
 20
 0.97
chr8_23033869_23034540 0.65 Ank1
 ankyrin 1, erythroid
 895
 0.59
chr2_25195300_25197035 0.64 Tor4a
 torsin family 4, member A
 592
 0.43
chr18_39485704_39487567 0.61 Nr3c1
 nuclear receptor subfamily 3, group C, member 1
 597
 0.82
chr16_35906184_35906335 0.60 Gm10237
 predicted gene 10237
 14205
 0.1
chr6_5154616_5154962 0.60 Pon1
 paraoxonase 1
 38974
 0.14
chr4_3937146_3938329 0.60 Plag1
 pleiomorphic adenoma gene 1
 645
 0.54
chr15_55090547_55090998 0.54 Dscc1
 DNA replication and sister chromatid cohesion 1
 281
 0.87
chr8_109737737_109738073 0.54 Atxn1l
 ataxin 1-like
 166
 0.94
chr14_31020219_31020404 0.52 Pbrm1
 polybromo 1
 1103
 0.23
chr11_29172094_29172676 0.51 Ppp4r3b
 protein phosphatase 4 regulatory subunit 3B
 505
 0.68
chr10_81140191_81141251 0.49 Zbtb7a
 zinc finger and BTB domain containing 7a
 2768
 0.1
chr5_42777354_42777505 0.49 Gm5554
 predicted gene 5554
 187180
 0.03
chr16_17619128_17619354 0.48 Smpd4
 sphingomyelin phosphodiesterase 4
 113
 0.94
chr5_77405086_77405486 0.48 Igfbp7
 insulin-like growth factor binding protein 7
 2754
 0.21
chr15_84719703_84721036 0.47 Gm20556
 predicted gene, 20556
 103
 0.74
chrX_101527905_101528056 0.47 Taf1
 TATA-box binding protein associated factor 1
 4754
 0.17
chr16_16146027_16146765 0.46 Spidr
 scaffolding protein involved in DNA repair
 408
 0.87
chrX_105069174_105070104 0.46 5530601H04Rik
 RIKEN cDNA 5530601H04 gene
 396
 0.82
chr17_56040358_56041583 0.44 Chaf1a
 chromatin assembly factor 1, subunit A (p150)
 531
 0.58
chr13_52584896_52585203 0.44 Syk
 spleen tyrosine kinase
 1546
 0.51
chrX_103622717_103623702 0.44 Ftx
 Ftx transcript, Xist regulator (non-protein coding)
 454
 0.67
chr7_67917220_67917371 0.44 Gm44666
 predicted gene 44666
 30710
 0.15
chr12_24706703_24706854 0.43 Rrm2
 ribonucleotide reductase M2
 1463
 0.32
chr11_90388814_90389066 0.43 Hlf
 hepatic leukemia factor
 650
 0.8
chrX_167228790_167228941 0.42 Tmsb4x
 thymosin, beta 4, X chromosome
 19550
 0.17
chr18_42513548_42513699 0.42 Tcerg1
 transcription elongation regulator 1 (CA150)
 2100
 0.3
chrX_169418936_169419087 0.42 Gm15245
 predicted gene 15245
 28819
 0.19
chr9_51009335_51009739 0.41 Sik2
 salt inducible kinase 2
 464
 0.81
chr3_126996871_126998855 0.41 Ank2
 ankyrin 2, brain
 575
 0.63
chr19_4155059_4155512 0.41 Ptprcap
 protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
 679
 0.33
chr16_91417240_91417391 0.41 Il10rb
 interleukin 10 receptor, beta
 10871
 0.1
chr19_24279590_24279827 0.40 Fxn
 frataxin
 860
 0.58
chr2_61655339_61656639 0.39 Tank
 TRAF family member-associated Nf-kappa B activator
 12158
 0.22
chr10_111010981_111011344 0.38 Zdhhc17
 zinc finger, DHHC domain containing 17
 1022
 0.57
chr12_55835950_55836196 0.38 Brms1l
 breast cancer metastasis-suppressor 1-like
 251
 0.89
chr6_29495887_29496782 0.35 Kcp
 kielin/chordin-like protein
 420
 0.71
chr1_132138543_132139629 0.34 Gm29629
 predicted gene 29629
 418
 0.51
chr8_94917668_94918304 0.34 Ccdc102a
 coiled-coil domain containing 102A
 112
 0.94
chr15_78845284_78846270 0.33 Cdc42ep1
 CDC42 effector protein (Rho GTPase binding) 1
 3153
 0.12
chr9_57763587_57763764 0.33 Clk3
 CDC-like kinase 3
 633
 0.65
chr6_34780141_34780388 0.32 Agbl3
 ATP/GTP binding protein-like 3
 168
 0.92
chr7_19769512_19770898 0.32 Bcam
 basal cell adhesion molecule
 290
 0.54
chr1_77226872_77227510 0.32 Gm38265
 predicted gene, 38265
 80199
 0.1
chr12_4233425_4233915 0.30 Cenpo
 centromere protein O
 268
 0.55
chr13_4942359_4942524 0.30 Gm47450
 predicted gene, 47450
 611
 0.84
chr17_71259969_71260163 0.30 Emilin2
 elastin microfibril interfacer 2
 3720
 0.19
chr12_102757182_102757722 0.29 Gm28051
 predicted gene, 28051
 313
 0.38
chr8_46615820_46616038 0.29 Primpol
 primase and polymerase (DNA-directed)
 1253
 0.31
chr17_84878392_84878652 0.28 Gm49982
 predicted gene, 49982
 24047
 0.14
chr7_5062843_5063444 0.28 U2af2
 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
 839
 0.26
chr2_128157307_128157458 0.28 Bcl2l11
 BCL2-like 11 (apoptosis facilitator)
 29251
 0.16
chr15_8967409_8968940 0.27 Ranbp3l
 RAN binding protein 3-like
 172
 0.96
chr12_56529878_56530592 0.27 Sfta3-ps
 surfactant associated 3, pseudogene
 808
 0.49
chr12_12941909_12942444 0.27 Mycn
 v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
 262
 0.88
chrX_155337145_155337602 0.27 Prdx4
 peroxiredoxin 4
 1094
 0.5
chr3_103777430_103777672 0.27 Gm15886
 predicted gene 15886
 136
 0.9
chr18_35739288_35740804 0.26 Sting1
 stimulator of interferon response cGAMP interactor 1
 30
 0.95
chr5_139406928_139407938 0.26 C130050O18Rik
 RIKEN cDNA C130050O18 gene
 968
 0.41
chr4_115062473_115064166 0.26 Tal1
 T cell acute lymphocytic leukemia 1
 3811
 0.18
chr10_83353735_83354451 0.26 D10Wsu102e
 DNA segment, Chr 10, Wayne State University 102, expressed
 6128
 0.17
chrX_85576113_85576674 0.26 Tab3
 TGF-beta activated kinase 1/MAP3K7 binding protein 3
 2243
 0.33
chr9_115165880_115166031 0.26 Gm4665
 predicted gene 4665
 20103
 0.15
chr8_112010916_112011253 0.26 Kars
 lysyl-tRNA synthetase
 182
 0.65
chr8_41055977_41056328 0.26 Mtus1
 mitochondrial tumor suppressor 1
 1358
 0.36
chr13_23695605_23696868 0.26 H1f6
 H1.6 linker histone, cluster member
 422
 0.53
chr8_48921826_48922154 0.25 Gm25830
 predicted gene, 25830
 36491
 0.18
chr15_36779468_36779639 0.25 Ywhaz
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
 12861
 0.15
chr2_103117112_103117263 0.25 Gm10038
 predicted gene 10038
 18032
 0.16
chr2_130663815_130664360 0.25 Ddrgk1
 DDRGK domain containing 1
 78
 0.95
chr18_38542410_38543000 0.24 Gm19100
 predicted gene, 19100
 40145
 0.12
chr3_95661677_95663214 0.24 Mcl1
 myeloid cell leukemia sequence 1
 3588
 0.13
chr11_26386745_26387188 0.24 Fancl
 Fanconi anemia, complementation group L
 236
 0.94
chr13_30338441_30338963 0.23 Agtr1a
 angiotensin II receptor, type 1a
 2258
 0.33
chr1_128591274_128591937 0.23 Cxcr4
 chemokine (C-X-C motif) receptor 4
 685
 0.72
chr11_88194059_88194740 0.23 Cuedc1
 CUE domain containing 1
 6578
 0.18
chr11_103131831_103132857 0.22 Hexim2
 hexamethylene bis-acetamide inducible 2
 85
 0.95
chr2_93460789_93461036 0.22 Cd82
 CD82 antigen
 1000
 0.52
chr5_31494777_31495631 0.22 4930566F21Rik
 RIKEN cDNA 4930566F21 gene
 25
 0.71
chrX_96095788_96097365 0.22 Msn
 moesin
 479
 0.84
chr1_86581881_86582496 0.22 Pde6d
 phosphodiesterase 6D, cGMP-specific, rod, delta
 329
 0.68
chr18_74216226_74217021 0.22 Cxxc1
 CXXC finger 1 (PHD domain)
 492
 0.76
chr7_36166793_36167655 0.21 Rpl17-ps9
 ribosomal protein L17, pseudogene 9
 48950
 0.14
chr11_70653066_70653217 0.21 Pfn1
 profilin 1
 1457
 0.15
chr1_173333573_173334024 0.21 Ackr1
 atypical chemokine receptor 1 (Duffy blood group)
 48
 0.97
chr12_109454708_109455197 0.21 Dlk1
 delta like non-canonical Notch ligand 1
 757
 0.48
chr16_22263818_22263981 0.21 Tra2b
 transformer 2 beta
 2001
 0.22
chr7_16048455_16049177 0.20 Bicra
 BRD4 interacting chromatin remodeling complex associated protein
 895
 0.48
chr11_115133328_115133870 0.20 Cd300lf
 CD300 molecule like family member F
 392
 0.78
chr3_130708012_130708163 0.20 Ostc
 oligosaccharyltransferase complex subunit (non-catalytic)
 1329
 0.3
chr5_119669544_119672401 0.20 Tbx3
 T-box 3
 46
 0.85
chr2_164769936_164770914 0.20 Ube2c
 ubiquitin-conjugating enzyme E2C
 522
 0.43
chr2_141701214_141701365 0.20 Gm25583
 predicted gene, 25583
 60799
 0.15
chr10_4335326_4335935 0.19 Akap12
 A kinase (PRKA) anchor protein (gravin) 12
 1085
 0.51
chr16_32163732_32163961 0.19 Nrros
 negative regulator of reactive oxygen species
 1611
 0.27
chr5_115011202_115012397 0.18 Sppl3
 signal peptide peptidase 3
 302
 0.81
chr15_82340829_82341556 0.18 Pheta2
 PH domain containing endocytic trafficking adaptor 2
 13
 0.7
chr9_96713030_96713604 0.18 Zbtb38
 zinc finger and BTB domain containing 38
 6248
 0.17
chr3_41522196_41522994 0.18 2400006E01Rik
 RIKEN cDNA 2400006E01 gene
 622
 0.65
chr2_26504256_26504407 0.18 Notch1
 notch 1
 507
 0.67
chr17_31854730_31855751 0.17 Sik1
 salt inducible kinase 1
 553
 0.73
chr19_10060014_10060673 0.17 Fads3
 fatty acid desaturase 3
 4091
 0.15
chr13_5863142_5863416 0.17 Klf6
 Kruppel-like factor 6
 1399
 0.37
chr16_35938449_35939599 0.17 Parp9
 poly (ADP-ribose) polymerase family, member 9
 6
 0.62
chr11_98446534_98448432 0.17 Grb7
 growth factor receptor bound protein 7
 415
 0.68
chr6_144779851_144780433 0.16 Sox5
 SRY (sex determining region Y)-box 5
 1777
 0.35
chr5_116023370_116024380 0.16 Prkab1
 protein kinase, AMP-activated, beta 1 non-catalytic subunit
 481
 0.72
chr2_165503533_165504813 0.16 Slc2a10
 solute carrier family 2 (facilitated glucose transporter), member 10
 386
 0.83
chr7_83655450_83655601 0.16 Il16
 interleukin 16
 30
 0.96
chr9_113935917_113936072 0.16 Ubp1
 upstream binding protein 1
 4340
 0.24
chr9_120541681_120542670 0.16 Entpd3
 ectonucleoside triphosphate diphosphohydrolase 3
 2357
 0.19
chr5_108627720_108627895 0.16 Gak
 cyclin G associated kinase
 1616
 0.22
chr5_113162472_113162792 0.16 2900026A02Rik
 RIKEN cDNA 2900026A02 gene
 719
 0.53
chr17_35236085_35236459 0.16 Atp6v1g2
 ATPase, H+ transporting, lysosomal V1 subunit G2
 290
 0.52
chr5_137293236_137293846 0.15 Mir8116
 microRNA 8116
 239
 0.76
chr3_67553510_67553744 0.15 Gm35299
 predicted gene, 35299
 202
 0.91
chr11_61143898_61144049 0.15 Tnfrsf13b
 tumor necrosis factor receptor superfamily, member 13b
 1308
 0.36
chr4_43558006_43559275 0.15 Tln1
 talin 1
 180
 0.86
chr13_73475681_73476013 0.15 Lpcat1
 lysophosphatidylcholine acyltransferase 1
 4096
 0.26
chr5_137644960_137646061 0.15 Irs3
 insulin receptor substrate 3
 27
 0.93
chr12_12809914_12811298 0.15 Platr19
 pluripotency associated transcript 19
 22621
 0.16
chr6_67035606_67035757 0.15 E230016M11Rik
 RIKEN cDNA E230016M11 gene
 918
 0.38
chr2_137163627_137163778 0.15 Gm28214
 predicted gene 28214
 35281
 0.19
chr11_120948479_120950230 0.15 Slc16a3
 solute carrier family 16 (monocarboxylic acid transporters), member 3
 273
 0.84
chr15_58075383_58076476 0.15 Gm29394
 predicted gene 29394
 254
 0.51
chr9_107887731_107888070 0.15 Mon1a
 MON1 homolog A, secretory traffciking associated
 251
 0.83
chr3_34081420_34081639 0.14 Dnajc19
 DnaJ heat shock protein family (Hsp40) member C19
 208
 0.91
chr9_62341355_62342874 0.14 Anp32a
 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
 39
 0.98
chr13_101719192_101719926 0.14 Pik3r1
 phosphoinositide-3-kinase regulatory subunit 1
 17455
 0.2
chr11_45805879_45806041 0.14 F630206G17Rik
 RIKEN cDNA F630206G17 gene
 2127
 0.25
chr11_51805212_51805363 0.14 Sar1b
 secretion associated Ras related GTPase 1B
 41593
 0.1
chr6_149310794_149310945 0.14 Resf1
 retroelement silencing factor 1
 547
 0.72
chr8_26329826_26330767 0.14 Gm31784
 predicted gene, 31784
 17962
 0.15
chr13_21808867_21809156 0.14 Hist1h2bq
 histone cluster 1, H2bq
 1186
 0.14
chr2_26960566_26960717 0.14 Rexo4
 REX4, 3'-5' exonuclease
 375
 0.71
chr16_89774022_89774482 0.14 Tiam1
 T cell lymphoma invasion and metastasis 1
 21030
 0.25
chr1_13573788_13574085 0.14 Tram1
 translocating chain-associating membrane protein 1
 5862
 0.23
chrX_94178531_94178700 0.14 Eif2s3x
 eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
 34036
 0.13
chr2_76069049_76070775 0.13 Pde11a
 phosphodiesterase 11A
 63869
 0.11
chr14_34541288_34541439 0.13 9230112D13Rik
 RIKEN cDNA 9230112D13 gene
 18562
 0.11
chr12_59096249_59096457 0.13 Mia2
 MIA SH3 domain ER export factor 2
 553
 0.61
chr6_37440238_37440988 0.13 Creb3l2
 cAMP responsive element binding protein 3-like 2
 1533
 0.51
chr5_115161343_115161682 0.13 Mlec
 malectin
 3333
 0.13
chr1_71102531_71102932 0.13 Bard1
 BRCA1 associated RING domain 1
 415
 0.89
chr11_88046995_88047496 0.13 Srsf1
 serine and arginine-rich splicing factor 1
 128
 0.89
chr7_123370221_123370652 0.13 Arhgap17
 Rho GTPase activating protein 17
 521
 0.52
chr5_150466366_150466940 0.13 Fry
 FRY microtubule binding protein
 6007
 0.12
chr1_135100584_135100735 0.13 Lgr6
 leucine-rich repeat-containing G protein-coupled receptor 6
 4617
 0.13
chr13_21834970_21835121 0.13 Hist1h2br
 histone cluster 1 H2br
 1287
 0.14
chr1_163403739_163404178 0.13 Gorab
 golgin, RAB6-interacting
 289
 0.88
chr6_15721115_15721384 0.13 Mdfic
 MyoD family inhibitor domain containing
 162
 0.97
chr17_35234891_35235777 0.13 Atp6v1g2
 ATPase, H+ transporting, lysosomal V1 subunit G2
 246
 0.57
chr7_19149532_19150194 0.12 Snrpd2
 small nuclear ribonucleoprotein D2
 4
 0.89
chr1_189686405_189686680 0.12 Gm37239
 predicted gene, 37239
 1214
 0.37
chr11_95307762_95307991 0.12 Kat7
 K(lysine) acetyltransferase 7
 1637
 0.25
chr13_112196563_112197178 0.12 Gm37427
 predicted gene, 37427
 22323
 0.16
chr16_55893274_55893677 0.12 Nxpe3
 neurexophilin and PC-esterase domain family, member 3
 1810
 0.26
chr18_65573679_65573830 0.12 Zfp532
 zinc finger protein 532
 6158
 0.12
chr1_172500186_172501427 0.12 Tagln2
 transgelin 2
 446
 0.68
chr4_43000753_43000935 0.12 Vcp
 valosin containing protein
 337
 0.78
chr17_71598006_71598722 0.12 Trmt61b
 tRNA methyltransferase 61B
 111
 0.93
chr3_146047158_146048273 0.12 Wdr63
 WD repeat domain 63
 530
 0.75
chr2_93662569_93662820 0.12 Alx4
 aristaless-like homeobox 4
 20306
 0.21
chr11_78114987_78115399 0.12 Fam222b
 family with sequence similarity 222, member B
 413
 0.67
chr4_46043005_46043156 0.12 Tmod1
 tropomodulin 1
 3871
 0.23
chr18_84858127_84859558 0.12 Gm16146
 predicted gene 16146
 705
 0.62
chr13_17694404_17694787 0.12 Sugct
 succinyl-CoA glutarate-CoA transferase
 141
 0.85
chr8_71394310_71395972 0.12 Ushbp1
 USH1 protein network component harmonin binding protein 1
 644
 0.48
chr5_21735334_21735486 0.12 Pmpcb
 peptidase (mitochondrial processing) beta
 1731
 0.26
chr4_141259880_141260037 0.11 Gm13055
 predicted gene 13055
 6058
 0.11
chr1_131276506_131276860 0.11 Ikbke
 inhibitor of kappaB kinase epsilon
 30
 0.96
chr16_78540388_78540947 0.11 D16Ertd472e
 DNA segment, Chr 16, ERATO Doi 472, expressed
 19577
 0.16
chr7_102065578_102066088 0.11 Xntrpc
 Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough
 55
 0.47
chr16_17125146_17125542 0.11 2610318N02Rik
 RIKEN cDNA 2610318N02 gene
 177
 0.79
chr15_5243299_5243450 0.11 Ptger4
 prostaglandin E receptor 4 (subtype EP4)
 664
 0.64
chr8_70673716_70674178 0.11 Lsm4
 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
 515
 0.58
chr11_48801825_48801976 0.11 Snord96a
 small nucleolar RNA, C/D box 96A
 132
 0.85
chr9_35115992_35116896 0.11 4930581F22Rik
 RIKEN cDNA 4930581F22 gene
 284
 0.61
chr5_115155040_115155560 0.11 Mlec
 malectin
 2879
 0.14
chr1_34439928_34440462 0.11 Imp4
 IMP4, U3 small nucleolar ribonucleoprotein
 154
 0.78
chr11_120241958_120242232 0.11 Bahcc1
 BAH domain and coiled-coil containing 1
 5396
 0.11
chr17_70987811_70988344 0.11 Myl12b
 myosin, light chain 12B, regulatory
 2453
 0.16
chr12_117657998_117660727 0.11 Rapgef5
 Rap guanine nucleotide exchange factor (GEF) 5
 1328
 0.51
chr17_87283765_87283916 0.11 Ttc7
 tetratricopeptide repeat domain 7
 889
 0.39
chr4_109678590_109678909 0.11 Faf1
 Fas-associated factor 1
 1752
 0.31
chr13_9494460_9495468 0.11 Gm48871
 predicted gene, 48871
 49064
 0.12
chr19_42751879_42752099 0.11 Pyroxd2
 pyridine nucleotide-disulphide oxidoreductase domain 2
 483
 0.75
chrX_19166017_19167833 0.11 Gm14636
 predicted gene 14636
 307
 0.9
chr3_121903244_121903507 0.11 Gm42593
 predicted gene 42593
 40533
 0.12
chr11_115832199_115833263 0.10 Llgl2
 LLGL2 scribble cell polarity complex component
 763
 0.46
chr5_52189299_52190481 0.10 Dhx15
 DEAH (Asp-Glu-Ala-His) box polypeptide 15
 487
 0.56
chr2_164431743_164432359 0.10 Sdc4
 syndecan 4
 11135
 0.08

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 0.5 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.2 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1 0.3 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1 0.5 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 0.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.4 GO:0072757 cellular response to camptothecin(GO:0072757)
0.1 0.2 GO:0032672 regulation of interleukin-3 production(GO:0032672)
0.1 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.3 GO:0098904 regulation of AV node cell action potential(GO:0098904)
0.1 0.3 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.2 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 0.2 GO:0019230 proprioception(GO:0019230)
0.1 0.2 GO:0060931 sinoatrial node cell development(GO:0060931)
0.1 0.2 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.8 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.2 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.1 GO:0060948 cardiac vascular smooth muscle cell development(GO:0060948)
0.0 0.0 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.2 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.2 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.1 GO:1902065 response to L-glutamate(GO:1902065)
0.0 0.1 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077)
0.0 0.1 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.1 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.3 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.1 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.1 GO:0085020 protein K6-linked ubiquitination(GO:0085020)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.0 0.1 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.1 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.2 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.4 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0060375 regulation of mast cell differentiation(GO:0060375)
0.0 0.2 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.0 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.0 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.1 GO:1902669 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of axon guidance(GO:1902669)
0.0 0.0 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0 0.0 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.1 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.0 GO:1904023 regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 0.1 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.0 GO:0048478 replication fork protection(GO:0048478)
0.0 0.0 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.0 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0 0.0 GO:0046104 thymidine metabolic process(GO:0046104)
0.0 0.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0 0.0 GO:0010255 carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.0 0.0 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.8 GO:0051233 spindle midzone(GO:0051233)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.0 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.1 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.0 GO:0030689 Noc complex(GO:0030689)
0.0 0.0 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.0 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.5 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.5 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.2 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.0 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0031711 bradykinin receptor binding(GO:0031711)
0.0 0.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.1 GO:0043910 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0 0.1 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.0 GO:0019961 interferon binding(GO:0019961)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.0 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.0 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.0 GO:0034513 box H/ACA snoRNA binding(GO:0034513)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID E2F PATHWAY E2F transcription factor network
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+