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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for E2f8

Z-value: 0.44

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Transcription factors associated with E2f8

Gene Symbol	Gene ID	Gene Info
E2f8 Ensembl NCBI MGI UniProt	ENSMUSG00000046179.11	E2f8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
E2f8	chr7_48881832_48882357	498	0.562900	0.59	5.8e-07	Click!
E2f8	chr7_48880272_48881025	356	0.649135	0.55	6.5e-06	Click!
E2f8	chr7_48879180_48879915	1457	0.262861	0.50	5.5e-05	Click!
E2f8	chr7_48881221_48881734	119	0.577878	0.34	8.2e-03	Click!
E2f8	chr7_48865527_48865678	9649	0.132537	-0.26	4.1e-02	Click!

Activity of the E2f8 motif across conditions

Conditions sorted by the z-value of the E2f8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_3398628_3399056	1.15	Samd9l	sterile alpha motif domain containing 9-like	730	0.64
chr12_24708730_24709261	1.08	Rrm2	ribonucleotide reductase M2	34	0.97
chr11_117810234_117810545	0.89	Syngr2	synaptogyrin 2	677	0.33
chr11_98907694_98909099	0.88	Cdc6	cell division cycle 6	245	0.86
chr6_127034730_127034972	0.78	Fgf6	fibroblast growth factor 6	19265	0.11
chr5_17848306_17848609	0.78	Cd36	CD36 molecule	1272	0.61
chr19_6305921_6306134	0.76	Cdc42bpg	CDC42 binding protein kinase gamma (DMPK-like)	429	0.64
chr13_51648729_51649046	0.73	Gm22806	predicted gene, 22806	688	0.62
chr9_100643671_100643909	0.71	Stag1	stromal antigen 1	20	0.97
chr8_23033869_23034540	0.65	Ank1	ankyrin 1, erythroid	895	0.59
chr2_25195300_25197035	0.64	Tor4a	torsin family 4, member A	592	0.43
chr18_39485704_39487567	0.61	Nr3c1	nuclear receptor subfamily 3, group C, member 1	597	0.82
chr16_35906184_35906335	0.60	Gm10237	predicted gene 10237	14205	0.1
chr6_5154616_5154962	0.60	Pon1	paraoxonase 1	38974	0.14
chr4_3937146_3938329	0.60	Plag1	pleiomorphic adenoma gene 1	645	0.54
chr15_55090547_55090998	0.54	Dscc1	DNA replication and sister chromatid cohesion 1	281	0.87
chr8_109737737_109738073	0.54	Atxn1l	ataxin 1-like	166	0.94
chr14_31020219_31020404	0.52	Pbrm1	polybromo 1	1103	0.23
chr11_29172094_29172676	0.51	Ppp4r3b	protein phosphatase 4 regulatory subunit 3B	505	0.68
chr10_81140191_81141251	0.49	Zbtb7a	zinc finger and BTB domain containing 7a	2768	0.1
chr5_42777354_42777505	0.49	Gm5554	predicted gene 5554	187180	0.03
chr16_17619128_17619354	0.48	Smpd4	sphingomyelin phosphodiesterase 4	113	0.94
chr5_77405086_77405486	0.48	Igfbp7	insulin-like growth factor binding protein 7	2754	0.21
chr15_84719703_84721036	0.47	Gm20556	predicted gene, 20556	103	0.74
chrX_101527905_101528056	0.47	Taf1	TATA-box binding protein associated factor 1	4754	0.17
chr16_16146027_16146765	0.46	Spidr	scaffolding protein involved in DNA repair	408	0.87
chrX_105069174_105070104	0.46	5530601H04Rik	RIKEN cDNA 5530601H04 gene	396	0.82
chr17_56040358_56041583	0.44	Chaf1a	chromatin assembly factor 1, subunit A (p150)	531	0.58
chr13_52584896_52585203	0.44	Syk	spleen tyrosine kinase	1546	0.51
chrX_103622717_103623702	0.44	Ftx	Ftx transcript, Xist regulator (non-protein coding)	454	0.67
chr7_67917220_67917371	0.44	Gm44666	predicted gene 44666	30710	0.15
chr12_24706703_24706854	0.43	Rrm2	ribonucleotide reductase M2	1463	0.32
chr11_90388814_90389066	0.43	Hlf	hepatic leukemia factor	650	0.8
chrX_167228790_167228941	0.42	Tmsb4x	thymosin, beta 4, X chromosome	19550	0.17
chr18_42513548_42513699	0.42	Tcerg1	transcription elongation regulator 1 (CA150)	2100	0.3
chrX_169418936_169419087	0.42	Gm15245	predicted gene 15245	28819	0.19
chr9_51009335_51009739	0.41	Sik2	salt inducible kinase 2	464	0.81
chr3_126996871_126998855	0.41	Ank2	ankyrin 2, brain	575	0.63
chr19_4155059_4155512	0.41	Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	679	0.33
chr16_91417240_91417391	0.41	Il10rb	interleukin 10 receptor, beta	10871	0.1
chr19_24279590_24279827	0.40	Fxn	frataxin	860	0.58
chr2_61655339_61656639	0.39	Tank	TRAF family member-associated Nf-kappa B activator	12158	0.22
chr10_111010981_111011344	0.38	Zdhhc17	zinc finger, DHHC domain containing 17	1022	0.57
chr12_55835950_55836196	0.38	Brms1l	breast cancer metastasis-suppressor 1-like	251	0.89
chr6_29495887_29496782	0.35	Kcp	kielin/chordin-like protein	420	0.71
chr1_132138543_132139629	0.34	Gm29629	predicted gene 29629	418	0.51
chr8_94917668_94918304	0.34	Ccdc102a	coiled-coil domain containing 102A	112	0.94
chr15_78845284_78846270	0.33	Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	3153	0.12
chr9_57763587_57763764	0.33	Clk3	CDC-like kinase 3	633	0.65
chr6_34780141_34780388	0.32	Agbl3	ATP/GTP binding protein-like 3	168	0.92
chr7_19769512_19770898	0.32	Bcam	basal cell adhesion molecule	290	0.54
chr1_77226872_77227510	0.32	Gm38265	predicted gene, 38265	80199	0.1
chr12_4233425_4233915	0.30	Cenpo	centromere protein O	268	0.55
chr13_4942359_4942524	0.30	Gm47450	predicted gene, 47450	611	0.84
chr17_71259969_71260163	0.30	Emilin2	elastin microfibril interfacer 2	3720	0.19
chr12_102757182_102757722	0.29	Gm28051	predicted gene, 28051	313	0.38
chr8_46615820_46616038	0.29	Primpol	primase and polymerase (DNA-directed)	1253	0.31
chr17_84878392_84878652	0.28	Gm49982	predicted gene, 49982	24047	0.14
chr7_5062843_5063444	0.28	U2af2	U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2	839	0.26
chr2_128157307_128157458	0.28	Bcl2l11	BCL2-like 11 (apoptosis facilitator)	29251	0.16
chr15_8967409_8968940	0.27	Ranbp3l	RAN binding protein 3-like	172	0.96
chr12_56529878_56530592	0.27	Sfta3-ps	surfactant associated 3, pseudogene	808	0.49
chr12_12941909_12942444	0.27	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	262	0.88
chrX_155337145_155337602	0.27	Prdx4	peroxiredoxin 4	1094	0.5
chr3_103777430_103777672	0.27	Gm15886	predicted gene 15886	136	0.9
chr18_35739288_35740804	0.26	Sting1	stimulator of interferon response cGAMP interactor 1	30	0.95
chr5_139406928_139407938	0.26	C130050O18Rik	RIKEN cDNA C130050O18 gene	968	0.41
chr4_115062473_115064166	0.26	Tal1	T cell acute lymphocytic leukemia 1	3811	0.18
chr10_83353735_83354451	0.26	D10Wsu102e	DNA segment, Chr 10, Wayne State University 102, expressed	6128	0.17
chrX_85576113_85576674	0.26	Tab3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	2243	0.33
chr9_115165880_115166031	0.26	Gm4665	predicted gene 4665	20103	0.15
chr8_112010916_112011253	0.26	Kars	lysyl-tRNA synthetase	182	0.65
chr8_41055977_41056328	0.26	Mtus1	mitochondrial tumor suppressor 1	1358	0.36
chr13_23695605_23696868	0.26	H1f6	H1.6 linker histone, cluster member	422	0.53
chr8_48921826_48922154	0.25	Gm25830	predicted gene, 25830	36491	0.18
chr15_36779468_36779639	0.25	Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	12861	0.15
chr2_103117112_103117263	0.25	Gm10038	predicted gene 10038	18032	0.16
chr2_130663815_130664360	0.25	Ddrgk1	DDRGK domain containing 1	78	0.95
chr18_38542410_38543000	0.24	Gm19100	predicted gene, 19100	40145	0.12
chr3_95661677_95663214	0.24	Mcl1	myeloid cell leukemia sequence 1	3588	0.13
chr11_26386745_26387188	0.24	Fancl	Fanconi anemia, complementation group L	236	0.94
chr13_30338441_30338963	0.23	Agtr1a	angiotensin II receptor, type 1a	2258	0.33
chr1_128591274_128591937	0.23	Cxcr4	chemokine (C-X-C motif) receptor 4	685	0.72
chr11_88194059_88194740	0.23	Cuedc1	CUE domain containing 1	6578	0.18
chr11_103131831_103132857	0.22	Hexim2	hexamethylene bis-acetamide inducible 2	85	0.95
chr2_93460789_93461036	0.22	Cd82	CD82 antigen	1000	0.52
chr5_31494777_31495631	0.22	4930566F21Rik	RIKEN cDNA 4930566F21 gene	25	0.71
chrX_96095788_96097365	0.22	Msn	moesin	479	0.84
chr1_86581881_86582496	0.22	Pde6d	phosphodiesterase 6D, cGMP-specific, rod, delta	329	0.68
chr18_74216226_74217021	0.22	Cxxc1	CXXC finger 1 (PHD domain)	492	0.76
chr7_36166793_36167655	0.21	Rpl17-ps9	ribosomal protein L17, pseudogene 9	48950	0.14
chr11_70653066_70653217	0.21	Pfn1	profilin 1	1457	0.15
chr1_173333573_173334024	0.21	Ackr1	atypical chemokine receptor 1 (Duffy blood group)	48	0.97
chr12_109454708_109455197	0.21	Dlk1	delta like non-canonical Notch ligand 1	757	0.48
chr16_22263818_22263981	0.21	Tra2b	transformer 2 beta	2001	0.22
chr7_16048455_16049177	0.20	Bicra	BRD4 interacting chromatin remodeling complex associated protein	895	0.48
chr11_115133328_115133870	0.20	Cd300lf	CD300 molecule like family member F	392	0.78
chr3_130708012_130708163	0.20	Ostc	oligosaccharyltransferase complex subunit (non-catalytic)	1329	0.3
chr5_119669544_119672401	0.20	Tbx3	T-box 3	46	0.85
chr2_164769936_164770914	0.20	Ube2c	ubiquitin-conjugating enzyme E2C	522	0.43
chr2_141701214_141701365	0.20	Gm25583	predicted gene, 25583	60799	0.15
chr10_4335326_4335935	0.19	Akap12	A kinase (PRKA) anchor protein (gravin) 12	1085	0.51
chr16_32163732_32163961	0.19	Nrros	negative regulator of reactive oxygen species	1611	0.27
chr5_115011202_115012397	0.18	Sppl3	signal peptide peptidase 3	302	0.81
chr15_82340829_82341556	0.18	Pheta2	PH domain containing endocytic trafficking adaptor 2	13	0.7
chr9_96713030_96713604	0.18	Zbtb38	zinc finger and BTB domain containing 38	6248	0.17
chr3_41522196_41522994	0.18	2400006E01Rik	RIKEN cDNA 2400006E01 gene	622	0.65
chr2_26504256_26504407	0.18	Notch1	notch 1	507	0.67
chr17_31854730_31855751	0.17	Sik1	salt inducible kinase 1	553	0.73
chr19_10060014_10060673	0.17	Fads3	fatty acid desaturase 3	4091	0.15
chr13_5863142_5863416	0.17	Klf6	Kruppel-like factor 6	1399	0.37
chr16_35938449_35939599	0.17	Parp9	poly (ADP-ribose) polymerase family, member 9	6	0.62
chr11_98446534_98448432	0.17	Grb7	growth factor receptor bound protein 7	415	0.68
chr6_144779851_144780433	0.16	Sox5	SRY (sex determining region Y)-box 5	1777	0.35
chr5_116023370_116024380	0.16	Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	481	0.72
chr2_165503533_165504813	0.16	Slc2a10	solute carrier family 2 (facilitated glucose transporter), member 10	386	0.83
chr7_83655450_83655601	0.16	Il16	interleukin 16	30	0.96
chr9_113935917_113936072	0.16	Ubp1	upstream binding protein 1	4340	0.24
chr9_120541681_120542670	0.16	Entpd3	ectonucleoside triphosphate diphosphohydrolase 3	2357	0.19
chr5_108627720_108627895	0.16	Gak	cyclin G associated kinase	1616	0.22
chr5_113162472_113162792	0.16	2900026A02Rik	RIKEN cDNA 2900026A02 gene	719	0.53
chr17_35236085_35236459	0.16	Atp6v1g2	ATPase, H+ transporting, lysosomal V1 subunit G2	290	0.52
chr5_137293236_137293846	0.15	Mir8116	microRNA 8116	239	0.76
chr3_67553510_67553744	0.15	Gm35299	predicted gene, 35299	202	0.91
chr11_61143898_61144049	0.15	Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	1308	0.36
chr4_43558006_43559275	0.15	Tln1	talin 1	180	0.86
chr13_73475681_73476013	0.15	Lpcat1	lysophosphatidylcholine acyltransferase 1	4096	0.26
chr5_137644960_137646061	0.15	Irs3	insulin receptor substrate 3	27	0.93
chr12_12809914_12811298	0.15	Platr19	pluripotency associated transcript 19	22621	0.16
chr6_67035606_67035757	0.15	E230016M11Rik	RIKEN cDNA E230016M11 gene	918	0.38
chr2_137163627_137163778	0.15	Gm28214	predicted gene 28214	35281	0.19
chr11_120948479_120950230	0.15	Slc16a3	solute carrier family 16 (monocarboxylic acid transporters), member 3	273	0.84
chr15_58075383_58076476	0.15	Gm29394	predicted gene 29394	254	0.51
chr9_107887731_107888070	0.15	Mon1a	MON1 homolog A, secretory traffciking associated	251	0.83
chr3_34081420_34081639	0.14	Dnajc19	DnaJ heat shock protein family (Hsp40) member C19	208	0.91
chr9_62341355_62342874	0.14	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	39	0.98
chr13_101719192_101719926	0.14	Pik3r1	phosphoinositide-3-kinase regulatory subunit 1	17455	0.2
chr11_45805879_45806041	0.14	F630206G17Rik	RIKEN cDNA F630206G17 gene	2127	0.25
chr11_51805212_51805363	0.14	Sar1b	secretion associated Ras related GTPase 1B	41593	0.1
chr6_149310794_149310945	0.14	Resf1	retroelement silencing factor 1	547	0.72
chr8_26329826_26330767	0.14	Gm31784	predicted gene, 31784	17962	0.15
chr13_21808867_21809156	0.14	Hist1h2bq	histone cluster 1, H2bq	1186	0.14
chr2_26960566_26960717	0.14	Rexo4	REX4, 3'-5' exonuclease	375	0.71
chr16_89774022_89774482	0.14	Tiam1	T cell lymphoma invasion and metastasis 1	21030	0.25
chr1_13573788_13574085	0.14	Tram1	translocating chain-associating membrane protein 1	5862	0.23
chrX_94178531_94178700	0.14	Eif2s3x	eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked	34036	0.13
chr2_76069049_76070775	0.13	Pde11a	phosphodiesterase 11A	63869	0.11
chr14_34541288_34541439	0.13	9230112D13Rik	RIKEN cDNA 9230112D13 gene	18562	0.11
chr12_59096249_59096457	0.13	Mia2	MIA SH3 domain ER export factor 2	553	0.61
chr6_37440238_37440988	0.13	Creb3l2	cAMP responsive element binding protein 3-like 2	1533	0.51
chr5_115161343_115161682	0.13	Mlec	malectin	3333	0.13
chr1_71102531_71102932	0.13	Bard1	BRCA1 associated RING domain 1	415	0.89
chr11_88046995_88047496	0.13	Srsf1	serine and arginine-rich splicing factor 1	128	0.89
chr7_123370221_123370652	0.13	Arhgap17	Rho GTPase activating protein 17	521	0.52
chr5_150466366_150466940	0.13	Fry	FRY microtubule binding protein	6007	0.12
chr1_135100584_135100735	0.13	Lgr6	leucine-rich repeat-containing G protein-coupled receptor 6	4617	0.13
chr13_21834970_21835121	0.13	Hist1h2br	histone cluster 1 H2br	1287	0.14
chr1_163403739_163404178	0.13	Gorab	golgin, RAB6-interacting	289	0.88
chr6_15721115_15721384	0.13	Mdfic	MyoD family inhibitor domain containing	162	0.97
chr17_35234891_35235777	0.13	Atp6v1g2	ATPase, H+ transporting, lysosomal V1 subunit G2	246	0.57
chr7_19149532_19150194	0.12	Snrpd2	small nuclear ribonucleoprotein D2	4	0.89
chr1_189686405_189686680	0.12	Gm37239	predicted gene, 37239	1214	0.37
chr11_95307762_95307991	0.12	Kat7	K(lysine) acetyltransferase 7	1637	0.25
chr13_112196563_112197178	0.12	Gm37427	predicted gene, 37427	22323	0.16
chr16_55893274_55893677	0.12	Nxpe3	neurexophilin and PC-esterase domain family, member 3	1810	0.26
chr18_65573679_65573830	0.12	Zfp532	zinc finger protein 532	6158	0.12
chr1_172500186_172501427	0.12	Tagln2	transgelin 2	446	0.68
chr4_43000753_43000935	0.12	Vcp	valosin containing protein	337	0.78
chr17_71598006_71598722	0.12	Trmt61b	tRNA methyltransferase 61B	111	0.93
chr3_146047158_146048273	0.12	Wdr63	WD repeat domain 63	530	0.75
chr2_93662569_93662820	0.12	Alx4	aristaless-like homeobox 4	20306	0.21
chr11_78114987_78115399	0.12	Fam222b	family with sequence similarity 222, member B	413	0.67
chr4_46043005_46043156	0.12	Tmod1	tropomodulin 1	3871	0.23
chr18_84858127_84859558	0.12	Gm16146	predicted gene 16146	705	0.62
chr13_17694404_17694787	0.12	Sugct	succinyl-CoA glutarate-CoA transferase	141	0.85
chr8_71394310_71395972	0.12	Ushbp1	USH1 protein network component harmonin binding protein 1	644	0.48
chr5_21735334_21735486	0.12	Pmpcb	peptidase (mitochondrial processing) beta	1731	0.26
chr4_141259880_141260037	0.11	Gm13055	predicted gene 13055	6058	0.11
chr1_131276506_131276860	0.11	Ikbke	inhibitor of kappaB kinase epsilon	30	0.96
chr16_78540388_78540947	0.11	D16Ertd472e	DNA segment, Chr 16, ERATO Doi 472, expressed	19577	0.16
chr7_102065578_102066088	0.11	Xntrpc	Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough	55	0.47
chr16_17125146_17125542	0.11	2610318N02Rik	RIKEN cDNA 2610318N02 gene	177	0.79
chr15_5243299_5243450	0.11	Ptger4	prostaglandin E receptor 4 (subtype EP4)	664	0.64
chr8_70673716_70674178	0.11	Lsm4	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	515	0.58
chr11_48801825_48801976	0.11	Snord96a	small nucleolar RNA, C/D box 96A	132	0.85
chr9_35115992_35116896	0.11	4930581F22Rik	RIKEN cDNA 4930581F22 gene	284	0.61
chr5_115155040_115155560	0.11	Mlec	malectin	2879	0.14
chr1_34439928_34440462	0.11	Imp4	IMP4, U3 small nucleolar ribonucleoprotein	154	0.78
chr11_120241958_120242232	0.11	Bahcc1	BAH domain and coiled-coil containing 1	5396	0.11
chr17_70987811_70988344	0.11	Myl12b	myosin, light chain 12B, regulatory	2453	0.16
chr12_117657998_117660727	0.11	Rapgef5	Rap guanine nucleotide exchange factor (GEF) 5	1328	0.51
chr17_87283765_87283916	0.11	Ttc7	tetratricopeptide repeat domain 7	889	0.39
chr4_109678590_109678909	0.11	Faf1	Fas-associated factor 1	1752	0.31
chr13_9494460_9495468	0.11	Gm48871	predicted gene, 48871	49064	0.12
chr19_42751879_42752099	0.11	Pyroxd2	pyridine nucleotide-disulphide oxidoreductase domain 2	483	0.75
chrX_19166017_19167833	0.11	Gm14636	predicted gene 14636	307	0.9
chr3_121903244_121903507	0.11	Gm42593	predicted gene 42593	40533	0.12
chr11_115832199_115833263	0.10	Llgl2	LLGL2 scribble cell polarity complex component	763	0.46
chr5_52189299_52190481	0.10	Dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	487	0.56
chr2_164431743_164432359	0.10	Sdc4	syndecan 4	11135	0.08

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2	0.5	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.2	0.5	GO:0034421	post-translational protein acetylation(GO:0034421)
0.1	1.2	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1	0.3	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1	0.5	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1	0.7	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.1	0.4	GO:0072757	cellular response to camptothecin(GO:0072757)
0.1	0.2	GO:0032672	regulation of interleukin-3 production(GO:0032672)
0.1	0.4	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.1	0.3	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.1	0.3	GO:0035610	protein side chain deglutamylation(GO:0035610)
0.1	0.2	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1	0.2	GO:0019230	proprioception(GO:0019230)
0.1	0.2	GO:0060931	sinoatrial node cell development(GO:0060931)
0.1	0.2	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.8	GO:0051984	positive regulation of chromosome segregation(GO:0051984)
0.0	0.2	GO:1990592	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0	0.2	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.0	0.1	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.0	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.0	0.2	GO:0035701	hematopoietic stem cell migration(GO:0035701)
0.0	0.1	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.2	GO:0045607	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:1902065	response to L-glutamate(GO:1902065)
0.0	0.1	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.0	0.3	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:0032077	positive regulation of deoxyribonuclease activity(GO:0032077)
0.0	0.1	GO:0048239	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0	0.1	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.3	GO:0060252	positive regulation of glial cell proliferation(GO:0060252)
0.0	0.1	GO:0010994	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0	0.1	GO:0085020	protein K6-linked ubiquitination(GO:0085020)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.1	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.0	0.1	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.1	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.0	0.2	GO:0042953	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.3	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0090209	negative regulation of triglyceride metabolic process(GO:0090209)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.4	GO:0072661	protein targeting to plasma membrane(GO:0072661)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.0	0.2	GO:0060330	regulation of response to interferon-gamma(GO:0060330)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.2	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.0	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.4	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0	0.0	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0	0.1	GO:1902669	positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of axon guidance(GO:1902669)
0.0	0.0	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.0	GO:0009804	coumarin metabolic process(GO:0009804)
0.0	0.1	GO:0015727	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0	0.0	GO:1904023	regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.2	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.0	0.1	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.0	GO:0031118	rRNA pseudouridine synthesis(GO:0031118)
0.0	0.0	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.1	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.1	GO:1904816	positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0	0.0	GO:0010255	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.0	0.0	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	0.3	GO:0033186	CAF-1 complex(GO:0033186)
0.1	0.5	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.1	0.4	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	0.2	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.8	GO:0051233	spindle midzone(GO:0051233)
0.0	0.3	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.2	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.2	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.3	GO:0070822	Sin3-type complex(GO:0070822)
0.0	0.1	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.0	0.2	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.0	GO:0070939	Dsl1p complex(GO:0070939)
0.0	0.1	GO:1990716	axonemal central apparatus(GO:1990716)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.2	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.3	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:1990423	RZZ complex(GO:1990423)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0089701	U2AF(GO:0089701)
0.0	0.0	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.5	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:0005688	U6 snRNP(GO:0005688)
0.0	0.1	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.0	GO:0030689	Noc complex(GO:0030689)
0.0	0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2	0.5	GO:0070538	oleic acid binding(GO:0070538)
0.1	0.5	GO:1990239	steroid hormone binding(GO:1990239)
0.1	0.6	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	0.4	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.1	0.5	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1	0.3	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	0.2	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.0	0.2	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.3	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.1	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.2	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0031711	bradykinin receptor binding(GO:0031711)
0.0	0.1	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0043910	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.2	GO:0045322	unmethylated CpG binding(GO:0045322)
0.0	0.1	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0008410	CoA-transferase activity(GO:0008410)
0.0	0.2	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0031493	nucleosomal histone binding(GO:0031493)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.0	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.0	0.1	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.2	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.0	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.3	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.2	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.3	GO:0033558	histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0	0.1	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.0	0.0	GO:0034513	box H/ACA snoRNA binding(GO:0034513)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
2.0	PID E2F PATHWAY	E2F transcription factor network
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5	PID BARD1 PATHWAY	BARD1 signaling events
0.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.6	PID LKB1 PATHWAY	LKB1 signaling events
0.3	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.4	PID RHOA PATHWAY	RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.8	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.3	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.5	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.3	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.2	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.1	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+