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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Esrrg

Z-value: 0.54

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Transcription factors associated with Esrrg

Gene Symbol	Gene ID	Gene Info
Esrrg Ensembl NCBI MGI UniProt	ENSMUSG00000026610.7	estrogen-related receptor gamma

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr1_187997341_187998650	Esrrg	127	0.972695	0.49	6.3e-05	Click!
chr1_187604626_187606001	Esrrg	3478	0.282480	0.45	3.3e-04	Click!
chr1_188001052_188001305	Esrrg	3310	0.295637	0.44	4.3e-04	Click!
chr1_187999916_188000681	Esrrg	2430	0.345336	0.42	8.9e-04	Click!
chr1_187998988_187999336	Esrrg	1294	0.524252	0.42	9.6e-04	Click!

Activity of the Esrrg motif across conditions

Conditions sorted by the z-value of the Esrrg motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_99513882_99514334	1.35	Map1b	microtubule-associated protein 1B	2410	0.23
chr2_181715341_181715994	1.12	Oprl1	opioid receptor-like 1	35	0.95
chr13_83722679_83723219	1.09	C130071C03Rik	RIKEN cDNA C130071C03 gene	1568	0.29
chr2_91119045_91119896	1.09	Mybpc3	myosin binding protein C, cardiac	1326	0.3
chr10_3368375_3368998	1.08	Ppp1r14c	protein phosphatase 1, regulatory inhibitor subunit 14C	2142	0.36
chr14_20663037_20663711	0.99	Synpo2l	synaptopodin 2-like	1200	0.26
chr10_69536775_69537233	0.97	Ank3	ankyrin 3, epithelial	2782	0.32
chr12_86680036_86680970	0.93	Vash1	vasohibin 1	1803	0.28
chr5_135248496_135249658	0.89	Fzd9	frizzled class receptor 9	2153	0.21
chr9_110765100_110765787	0.88	Myl3	myosin, light polypeptide 3	418	0.74
chr10_30840531_30840931	0.86	Hey2	hairy/enhancer-of-split related with YRPW motif 2	1284	0.43
chr7_126274286_126274741	0.85	Sbk1	SH3-binding kinase 1	1113	0.38
chr18_24711119_24711270	0.84	Fhod3	formin homology 2 domain containing 3	1749	0.28
chr9_56535349_56535646	0.84	Gm47176	predicted gene, 47176	4408	0.18
chr1_59766668_59766947	0.83	Bmpr2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	3407	0.19
chr9_56864653_56866648	0.82	Cspg4	chondroitin sulfate proteoglycan 4	617	0.51
chr4_143300007_143300403	0.81	Pdpn	podoplanin	641	0.68
chr9_97017174_97017806	0.81	Gm16010	predicted gene 16010	16	0.96
chr17_72921491_72924008	0.80	Lbh	limb-bud and heart	1561	0.47
chr6_85371815_85372854	0.79	Rab11fip5	RAB11 family interacting protein 5 (class I)	2230	0.24
chr10_80180425_80180593	0.77	Efna2	ephrin A2	1027	0.3
chr14_34822420_34823516	0.77	Grid1	glutamate receptor, ionotropic, delta 1	2860	0.27
chr14_101886945_101887764	0.76	Lmo7	LIM domain only 7	3235	0.35
chr13_83737592_83739114	0.74	Gm33366	predicted gene, 33366	182	0.66
chr16_94722721_94723264	0.73	Gm41505	predicted gene, 41505	1098	0.52
chr8_95703051_95704038	0.72	Ndrg4	N-myc downstream regulated gene 4	474	0.68
chr10_13322058_13322496	0.72	Phactr2	phosphatase and actin regulator 2	2012	0.42
chr10_111901253_111901501	0.71	Gm47880	predicted gene, 47880	12363	0.16
chr9_30920196_30920963	0.70	Adamts15	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15	371	0.88
chr18_60646141_60646566	0.68	Synpo	synaptopodin	1919	0.32
chr7_141428600_141429722	0.68	Cend1	cell cycle exit and neuronal differentiation 1	190	0.82
chrX_134295383_134296942	0.67	Tmem35a	transmembrane protein 35A	937	0.52
chr2_170731776_170732705	0.66	Dok5	docking protein 5	433	0.88
chr2_114048099_114048464	0.65	Actc1	actin, alpha, cardiac muscle 1	4606	0.18
chr6_38252574_38252916	0.65	D630045J12Rik	RIKEN cDNA D630045J12 gene	1210	0.46
chr17_81737002_81738450	0.64	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	651	0.81
chr5_114147552_114147966	0.64	Acacb	acetyl-Coenzyme A carboxylase beta	1224	0.34
chr10_127261534_127261755	0.64	Kif5a	kinesin family member 5A	1436	0.2
chr1_169746128_169746823	0.63	Rgs4	regulator of G-protein signaling 4	1148	0.55
chr14_55056074_55056891	0.63	Gm20687	predicted gene 20687	989	0.3
chr9_66512511_66514532	0.63	Fbxl22	F-box and leucine-rich repeat protein 22	1088	0.47
chr2_91126778_91126929	0.62	Mybpc3	myosin binding protein C, cardiac	8709	0.11
chr4_43406531_43407612	0.62	Rusc2	RUN and SH3 domain containing 2	258	0.87
chr8_110722042_110722638	0.61	Mtss2	MTSS I-BAR domain containing 2	864	0.55
chr15_25942778_25943455	0.61	Retreg1	reticulophagy regulator 1	437	0.83
chr11_111067503_111068134	0.61	Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	1654	0.5
chr11_68390483_68390938	0.61	Ntn1	netrin 1	3698	0.27
chr4_120813989_120815034	0.59	Nfyc	nuclear transcription factor-Y gamma	1201	0.36
chr7_87585368_87585534	0.59	Grm5	glutamate receptor, metabotropic 5	1053	0.67
chr19_10342009_10342277	0.59	Dagla	diacylglycerol lipase, alpha	37266	0.11
chr5_104461026_104461334	0.59	Pkd2	polycystin 2, transient receptor potential cation channel	1610	0.34
chr18_47525528_47525697	0.58	Gm5095	predicted gene 5095	12123	0.21
chr11_98929351_98930679	0.58	Rara	retinoic acid receptor, alpha	2197	0.18
chr9_65678023_65678538	0.58	Oaz2	ornithine decarboxylase antizyme 2	1689	0.32
chr7_19414891_19415097	0.58	Ckm	creatine kinase, muscle	3931	0.08
chrX_162025397_162025772	0.57	Gm26317	predicted gene, 26317	43873	0.17
chr12_100907442_100908590	0.57	Gpr68	G protein-coupled receptor 68	165	0.92
chr11_3368719_3370424	0.56	Limk2	LIM motif-containing protein kinase 2	409	0.76
chr8_12926230_12928559	0.56	Mcf2l	mcf.2 transforming sequence-like	762	0.52
chr17_32634501_32635224	0.56	Cyp4f37	cytochrome P450, family 4, subfamily f, polypeptide 37	160	0.92
chr8_82865753_82865928	0.55	Rnf150	ring finger protein 150	2026	0.38
chr2_114057084_114058386	0.55	C130080G10Rik	RIKEN cDNA C130080G10 gene	1422	0.37
chr6_114041186_114042349	0.55	Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	248	0.91
chr1_191720952_191721137	0.55	Lpgat1	lysophosphatidylglycerol acyltransferase 1	2523	0.25
chr9_107708227_107708656	0.55	Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	1038	0.34
chr13_117603755_117604285	0.55	Hcn1	hyperpolarization activated cyclic nucleotide gated potassium channel 1	1540	0.54
chr9_121792003_121792549	0.54	Hhatl	hedgehog acyltransferase-like	231	0.84
chr3_17789318_17789657	0.53	Mir124-2hg	Mir124-2 host gene (non-protein coding)	434	0.83
chr6_128032492_128033212	0.53	Tspan9	tetraspanin 9	1740	0.36
chr18_69523224_69524043	0.52	Tcf4	transcription factor 4	1183	0.58
chr5_69541689_69541957	0.52	Yipf7	Yip1 domain family, member 7	766	0.59
chr5_138992944_138993679	0.51	Pdgfa	platelet derived growth factor, alpha	970	0.48
chr10_9092809_9092960	0.50	Gm48743	predicted gene, 48743	21409	0.23
chr7_125831269_125831420	0.50	D430042O09Rik	RIKEN cDNA D430042O09 gene	1677	0.48
chr10_80151643_80151976	0.49	Midn	midnolin	571	0.53
chr1_77080723_77080989	0.49	Gm816	predicted gene 816	53064	0.14
chr15_76519928_76521866	0.49	Scrt1	scratch family zinc finger 1	1005	0.28
chr18_33460259_33461386	0.49	Nrep	neuronal regeneration related protein	2613	0.29
chr14_61257260_61257428	0.49	Sgcg	sarcoglycan, gamma (dystrophin-associated glycoprotein)	1080	0.45
chr12_86823362_86823513	0.47	Gm10095	predicted gene 10095	23030	0.17
chr3_107516925_107518261	0.47	Slc6a17	solute carrier family 6 (neurotransmitter transporter), member 17	156	0.95
chr14_105333345_105334016	0.47	Ndfip2	Nedd4 family interacting protein 2	39134	0.13
chr6_120483288_120483595	0.46	Il17ra	interleukin 17 receptor A	9838	0.13
chrX_157704254_157705325	0.46	Smpx	small muscle protein, X-linked	2191	0.25
chr4_123904447_123904800	0.46	Mycbp	MYC binding protein	209	0.77
chr6_16316653_16317675	0.46	Gm3148	predicted gene 3148	79537	0.1
chr2_76980555_76980961	0.45	Ttn	titin	576	0.81
chr7_93079849_93081191	0.45	Gm9934	predicted gene 9934	274	0.76
chr11_57836623_57837461	0.45	Hand1	heart and neural crest derivatives expressed 1	4224	0.18
chr4_150807641_150808455	0.45	Gm13049	predicted gene 13049	17685	0.16
chr1_40807253_40807432	0.44	Tmem182	transmembrane protein 182	1741	0.33
chr11_5802324_5803834	0.44	Pgam2	phosphoglycerate mutase 2	654	0.56
chr1_72826047_72827238	0.44	Igfbp2	insulin-like growth factor binding protein 2	1320	0.5
chr7_99350039_99350190	0.44	Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	2883	0.2
chr17_17827521_17828536	0.44	Spaca6	sperm acrosome associated 6	704	0.43
chr4_110050529_110051058	0.44	Dmrta2	doublesex and mab-3 related transcription factor like family A2	72740	0.11
chr4_119463634_119463785	0.44	Zmynd12	zinc finger, MYND domain containing 12	18989	0.09
chr2_150788802_150789695	0.44	Pygb	brain glycogen phosphorylase	242	0.91
chr18_49559060_49559779	0.43	Gm25440	predicted gene, 25440	22430	0.22
chr7_142474137_142474301	0.43	Lsp1	lymphocyte specific 1	775	0.47
chr12_29665011_29665344	0.43	C630031E19Rik	RIKEN cDNA C630031E19 gene	21268	0.26
chr5_104109155_104109917	0.43	Gm26703	predicted gene, 26703	245	0.88
chr11_94498570_94500249	0.43	Epn3	epsin 3	289	0.85
chr7_70338252_70338403	0.43	Gm29683	predicted gene, 29683	475	0.72
chr11_6604576_6606131	0.43	Nacad	NAC alpha domain containing	700	0.46
chrY_1041845_1042254	0.42	Gm29650	predicted gene 29650	6344	0.16
chr13_12104357_12104508	0.42	Ryr2	ryanodine receptor 2, cardiac	2027	0.32
chr10_57001100_57001565	0.42	Gm36827	predicted gene, 36827	19100	0.24
chr4_108830914_108831550	0.42	Btf3l4	basic transcription factor 3-like 4	681	0.59
chr2_178118695_178119817	0.42	Phactr3	phosphatase and actin regulator 3	77	0.98
chr13_47770992_47771224	0.42	4930471G24Rik	RIKEN cDNA 4930471G24 gene	103558	0.07
chr4_151137762_151138535	0.42	Camta1	calmodulin binding transcription activator 1	1436	0.47
chr17_6772344_6772495	0.41	Ezr	ezrin	10365	0.16
chr15_27786588_27788615	0.41	Trio	triple functional domain (PTPRF interacting)	1037	0.6
chr7_29066413_29066564	0.41	Gm26604	predicted gene, 26604	5115	0.1
chr18_37178155_37179152	0.41	Gm10544	predicted gene 10544	131	0.94
chr17_17448568_17449744	0.41	Lix1	limb and CNS expressed 1	336	0.88
chr14_45850711_45850862	0.41	Gm8317	predicted gene 8317	7760	0.2
chr7_46407345_46407496	0.40	Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	9772	0.16
chr1_57573806_57574059	0.40	Gm17929	predicted gene, 17929	9881	0.21
chr15_82277282_82277951	0.40	Septin3	septin 3	2216	0.14
chr11_21570140_21570702	0.40	Mdh1	malate dehydrogenase 1, NAD (soluble)	1513	0.29
chr4_129141555_129141750	0.40	Fndc5	fibronectin type III domain containing 5	4653	0.13
chr2_26339789_26340241	0.40	Gpsm1	G-protein signalling modulator 1 (AGS3-like, C. elegans)	567	0.56
chr8_11309069_11309952	0.40	Col4a1	collagen, type IV, alpha 1	3179	0.2
chr7_4516649_4516857	0.40	Tnnt1	troponin T1, skeletal, slow	371	0.69
chr1_118481967_118482873	0.39	Clasp1	CLIP associating protein 1	381	0.8
chr17_57058009_57058459	0.39	Crb3	crumbs family member 3	871	0.3
chr9_99662299_99662551	0.39	Dzip1l	DAZ interacting protein 1-like	12209	0.16
chr11_94045498_94046076	0.39	Spag9	sperm associated antigen 9	1422	0.4
chr6_137168523_137169703	0.39	Rerg	RAS-like, estrogen-regulated, growth-inhibitor	572	0.79
chr10_98967523_98967758	0.39	Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	18491	0.22
chr15_77021062_77022444	0.39	Mb	myoglobin	210	0.89
chr16_84549281_84549553	0.39	A730009L09Rik	RIKEN cDNA A730009L09 gene	34048	0.14
chr18_42444794_42444945	0.39	Gm16415	predicted pseudogene 16415	3850	0.22
chr14_55057067_55057894	0.39	Gm20687	predicted gene 20687	1987	0.14
chr14_60383740_60384237	0.39	Amer2	APC membrane recruitment 2	5702	0.23
chr2_163379610_163379927	0.39	Jph2	junctophilin 2	18181	0.13
chr2_13578293_13579079	0.38	Vim	vimentin	683	0.75
chr3_18049845_18050841	0.38	Bhlhe22	basic helix-loop-helix family, member e22	3831	0.23
chr4_108218802_108219449	0.38	Zyg11a	zyg-11 family member A, cell cycle regulator	1077	0.46
chr13_110018579_110019682	0.38	Pde4d	phosphodiesterase 4D, cAMP specific	83818	0.1
chr7_99467468_99467619	0.38	Klhl35	kelch-like 35	1420	0.27
chr10_95894136_95895107	0.37	Gm47725	predicted gene, 47725	1178	0.38
chr2_75086892_75087412	0.37	Gm13652	predicted gene 13652	50646	0.11
chr19_53679904_53680339	0.37	Rbm20	RNA binding motif protein 20	2815	0.26
chr3_75921070_75921248	0.37	Golim4	golgi integral membrane protein 4	18713	0.18
chr8_3606652_3606803	0.37	Camsap3	calmodulin regulated spectrin-associated protein family, member 3	389	0.68
chr17_47975965_47976586	0.37	Gm14871	predicted gene 14871	27297	0.11
chr6_25688825_25690399	0.37	Gpr37	G protein-coupled receptor 37	180	0.97
chr2_173270600_173271108	0.37	Pmepa1	prostate transmembrane protein, androgen induced 1	5335	0.2
chr3_102086617_102087454	0.36	Casq2	calsequestrin 2	396	0.81
chr3_134330789_134331989	0.36	Gm43558	predicted gene 43558	25903	0.15
chrX_143929366_143930062	0.36	Dcx	doublecortin	3336	0.34
chr6_6212569_6212720	0.36	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	4474	0.27
chr2_49787205_49788356	0.36	Lypd6b	LY6/PLAUR domain containing 6B	49	0.98
chr17_25462833_25463318	0.36	Tekt4	tektin 4	8460	0.11
chr15_103506702_103507198	0.35	Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	3673	0.17
chr13_15550714_15550912	0.35	Gli3	GLI-Kruppel family member GLI3	86833	0.07
chr10_80940377_80940528	0.35	Gadd45b	growth arrest and DNA-damage-inducible 45 beta	9640	0.09
chr16_20699849_20700000	0.35	Fam131a	family with sequence similarity 131, member A	3749	0.09
chr2_153035186_153035549	0.35	Xkr7	X-linked Kx blood group related 7	3515	0.16
chr9_58824792_58824943	0.35	Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	1455	0.49
chr17_78734767_78735199	0.35	Strn	striatin, calmodulin binding protein	2213	0.24
chr1_131522570_131523013	0.34	Srgap2	SLIT-ROBO Rho GTPase activating protein 2	4556	0.17
chr14_111680945_111682200	0.34	Slitrk5	SLIT and NTRK-like family, member 5	5723	0.23
chr19_5474276_5474674	0.34	Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	160	0.83
chr3_87996506_87997409	0.34	Bcan	brevican	308	0.8
chr10_80296711_80297037	0.34	Apc2	APC regulator of WNT signaling pathway 2	897	0.3
chr5_101365618_101366080	0.34	Cycs-ps2	cytochrome c, pseudogene 2	60271	0.14
chr11_95521077_95521771	0.34	Nxph3	neurexophilin 3	6854	0.18
chr9_47671566_47671717	0.34	Gm47198	predicted gene, 47198	99500	0.07
chr7_25069270_25070477	0.34	Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	2228	0.18
chr2_160871307_160871738	0.33	Zhx3	zinc fingers and homeoboxes 3	1050	0.42
chr13_48624936_48625515	0.33	Ptpdc1	protein tyrosine phosphatase domain containing 1	284	0.88
chr8_27263616_27263874	0.33	Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1	669	0.56
chr9_118480279_118480840	0.33	Eomes	eomesodermin	1698	0.28
chr17_24552226_24552377	0.33	Pkd1	polycystin 1, transient receptor poteintial channel interacting	2351	0.12
chr14_58113076_58113458	0.33	Gm17109	predicted gene 17109	7138	0.21
chr9_52052762_52052932	0.33	Rdx	radixin	4576	0.21
chr3_57625355_57625848	0.33	Gm26671	predicted gene, 26671	156	0.92
chr5_103209022_103210413	0.32	Mapk10	mitogen-activated protein kinase 10	705	0.75
chr14_58150040_58150734	0.32	Gm17109	predicted gene 17109	44258	0.14
chr17_34185809_34185960	0.32	Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	1335	0.17
chr14_8665553_8666279	0.32	4930452B06Rik	RIKEN cDNA 4930452B06 gene	323	0.62
chr8_45673773_45673924	0.32	Sorbs2	sorbin and SH3 domain containing 2	11852	0.21
chr16_85091082_85091583	0.31	Gm49227	predicted gene, 49227	11221	0.2
chr5_41766502_41767052	0.31	Nkx3-2	NK3 homeobox 2	2276	0.35
chr1_187653088_187653646	0.31	Gm36388	predicted gene, 36388	1543	0.4
chr4_141964364_141964893	0.31	Fhad1	forkhead-associated (FHA) phosphopeptide binding domain 1	10434	0.13
chr10_92159283_92159475	0.31	Rmst	rhabdomyosarcoma 2 associated transcript (non-coding RNA)	3382	0.26
chr4_105449104_105449638	0.31	Gm12723	predicted gene 12723	61861	0.13
chr1_83407298_83408547	0.31	Sphkap	SPHK1 interactor, AKAP domain containing	217	0.94
chr7_45240555_45241594	0.31	Slc6a16	solute carrier family 6, member 16	11	0.92
chr10_128896056_128896905	0.30	Cd63	CD63 antigen	4509	0.1
chr14_66792058_66792209	0.30	Gm9130	predicted gene 9130	6245	0.19
chr10_69536011_69536410	0.30	Ank3	ankyrin 3, epithelial	1988	0.39
chr8_79030967_79031125	0.30	Zfp827	zinc finger protein 827	2459	0.3
chr6_87432429_87432774	0.30	Bmp10	bone morphogenetic protein 10	3607	0.18
chr14_58072231_58072956	0.30	Fgf9	fibroblast growth factor 9	93	0.97

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esrrg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.3	0.8	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.2	1.2	GO:0071313	cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.2	0.6	GO:0035995	detection of muscle stretch(GO:0035995)
0.2	0.5	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.2	0.5	GO:0045218	zonula adherens maintenance(GO:0045218)
0.1	0.4	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1	0.5	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.1	0.4	GO:0035905	ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1	0.5	GO:1903059	regulation of protein lipidation(GO:1903059)
0.1	0.3	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.1	0.3	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1	0.6	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.1	0.4	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.1	0.4	GO:0036486	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.1	0.5	GO:0015884	folic acid transport(GO:0015884)
0.1	0.2	GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.1	0.5	GO:0048840	otolith development(GO:0048840)
0.1	0.3	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.1	0.3	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.1	0.2	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1	0.4	GO:1902047	polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267)
0.1	0.2	GO:1900238	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.1	0.4	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.1	0.3	GO:0060591	chondroblast differentiation(GO:0060591)
0.1	0.3	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1	0.7	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1	0.2	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.1	0.3	GO:0007258	JUN phosphorylation(GO:0007258)
0.1	0.6	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.1	0.2	GO:1905063	regulation of vascular smooth muscle cell differentiation(GO:1905063) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.1	0.4	GO:0045964	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.1	0.2	GO:0072092	ureteric bud invasion(GO:0072092)
0.1	0.2	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.1	0.2	GO:0035262	gonad morphogenesis(GO:0035262)
0.1	0.4	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.1	0.4	GO:0071321	cellular response to cGMP(GO:0071321)
0.1	0.4	GO:0042118	endothelial cell activation(GO:0042118)
0.1	0.2	GO:0071374	cellular response to parathyroid hormone stimulus(GO:0071374)
0.1	0.4	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1	0.2	GO:0018103	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1	0.2	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.1	0.2	GO:0016560	protein import into peroxisome matrix, docking(GO:0016560)
0.1	0.3	GO:1902262	apoptotic process involved in patterning of blood vessels(GO:1902262)
0.1	0.2	GO:1904659	glucose transmembrane transport(GO:1904659)
0.1	0.2	GO:1990928	response to amino acid starvation(GO:1990928)
0.1	0.2	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.1	0.1	GO:0003104	positive regulation of glomerular filtration(GO:0003104)
0.1	0.2	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.1	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1	0.3	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.1	0.2	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.1	0.2	GO:1900620	acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1	0.2	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.1	0.3	GO:0048842	positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of axon guidance(GO:1902669)
0.0	0.1	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.0	0.0	GO:1903726	negative regulation of phospholipid metabolic process(GO:1903726)
0.0	0.2	GO:0030091	protein repair(GO:0030091)
0.0	1.8	GO:0055010	ventricular cardiac muscle tissue morphogenesis(GO:0055010)
0.0	0.3	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.2	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.2	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:1902966	regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0	0.2	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.3	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.1	GO:0001698	gastrin-induced gastric acid secretion(GO:0001698)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0061314	Notch signaling involved in heart development(GO:0061314)
0.0	0.2	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.2	GO:0061591	calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.0	0.2	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.9	GO:0031114	regulation of microtubule depolymerization(GO:0031114)
0.0	0.0	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.0	0.1	GO:0035524	proline transmembrane transport(GO:0035524)
0.0	0.2	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0	0.1	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.2	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0	0.1	GO:0032289	central nervous system myelin formation(GO:0032289)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0	0.1	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	0.2	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.4	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.2	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.1	GO:0045054	constitutive secretory pathway(GO:0045054)
0.0	0.5	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.2	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.1	GO:1903242	regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.0	0.3	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.0	0.2	GO:0071442	positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0	0.2	GO:0048505	regulation of timing of cell differentiation(GO:0048505)
0.0	0.1	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.1	GO:0045415	negative regulation of interleukin-8 biosynthetic process(GO:0045415)
0.0	0.1	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
0.0	0.1	GO:0061198	fungiform papilla formation(GO:0061198)
0.0	0.1	GO:0098910	regulation of atrial cardiac muscle cell action potential(GO:0098910)
0.0	0.1	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.6	GO:0005980	glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.0	GO:2001182	regulation of interleukin-12 secretion(GO:2001182)
0.0	0.2	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0	0.2	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0043587	tongue morphogenesis(GO:0043587)
0.0	0.1	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.1	GO:0090214	spongiotrophoblast layer developmental growth(GO:0090214)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0016198	axon choice point recognition(GO:0016198)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.2	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.1	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.0	GO:0061317	canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317)
0.0	0.1	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.0	0.1	GO:0090310	negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0	0.1	GO:1903286	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:0035701	hematopoietic stem cell migration(GO:0035701)
0.0	0.0	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:2000852	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0	0.1	GO:0070126	mitochondrial translational termination(GO:0070126)
0.0	0.1	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0	0.1	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.0	0.1	GO:0002666	positive regulation of T cell tolerance induction(GO:0002666)
0.0	0.1	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0	0.1	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:0097012	response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0	0.0	GO:1901321	positive regulation of heart induction(GO:1901321)
0.0	0.1	GO:0061743	motor learning(GO:0061743)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.2	GO:0021756	striatum development(GO:0021756)
0.0	0.0	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.2	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.0	GO:0060478	acrosomal vesicle exocytosis(GO:0060478)
0.0	0.2	GO:0046218	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.0	GO:2000850	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0	0.0	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.2	GO:0045199	maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:0032788	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.1	GO:2000680	regulation of rubidium ion transport(GO:2000680)
0.0	0.4	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.1	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.0	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.0	0.0	GO:0035984	response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0060696	regulation of phospholipid catabolic process(GO:0060696)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.1	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0	0.1	GO:2000019	negative regulation of male gonad development(GO:2000019)
0.0	0.0	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.1	GO:0051794	regulation of catagen(GO:0051794)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.0	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0	0.1	GO:0010528	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.0	GO:0033602	negative regulation of dopamine secretion(GO:0033602)
0.0	0.1	GO:2000275	regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0	0.0	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.1	GO:0016103	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.2	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.3	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.1	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.0	0.0	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:2001201	transforming growth factor-beta secretion(GO:0038044) regulation of transforming growth factor-beta secretion(GO:2001201)
0.0	0.1	GO:1903849	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.2	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.0	0.0	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0	0.1	GO:0072318	clathrin coat disassembly(GO:0072318)
0.0	0.1	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0	0.2	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0061032	visceral serous pericardium development(GO:0061032)
0.0	0.3	GO:0014002	astrocyte development(GO:0014002)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.4	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	0.1	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0	0.0	GO:0098528	skeletal muscle fiber differentiation(GO:0098528)
0.0	0.1	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:1903441	protein localization to ciliary membrane(GO:1903441)
0.0	0.1	GO:0018119	peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.0	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:0060221	retinal rod cell differentiation(GO:0060221)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.0	GO:0033693	neurofilament bundle assembly(GO:0033693)
0.0	0.3	GO:0097352	autophagosome maturation(GO:0097352)
0.0	0.0	GO:0046959	habituation(GO:0046959)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.0	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.0	GO:0086029	Purkinje myocyte action potential(GO:0086017) Purkinje myocyte to ventricular cardiac muscle cell signaling(GO:0086029) Purkinje myocyte to ventricular cardiac muscle cell communication(GO:0086068)
0.0	0.1	GO:0009642	response to light intensity(GO:0009642)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.1	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.2	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.2	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.2	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.1	GO:0045113	regulation of integrin biosynthetic process(GO:0045113)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.1	GO:0043307	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil activation(GO:0043307) eosinophil degranulation(GO:0043308)
0.0	0.1	GO:1903599	positive regulation of mitophagy(GO:1903599)
0.0	0.1	GO:0071071	regulation of phospholipid biosynthetic process(GO:0071071)
0.0	0.1	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.4	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.0	GO:0060075	regulation of resting membrane potential(GO:0060075)
0.0	0.0	GO:1904936	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0	0.0	GO:0021558	trochlear nerve development(GO:0021558)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0071625	vocalization behavior(GO:0071625)
0.0	0.0	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.0	GO:0052203	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.0	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0	0.0	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.0	0.1	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.0	0.0	GO:0048371	lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370) lateral mesodermal cell differentiation(GO:0048371)
0.0	0.2	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
0.0	0.0	GO:0009794	regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0	0.0	GO:0014063	negative regulation of serotonin secretion(GO:0014063)
0.0	0.0	GO:1903011	negative regulation of bone development(GO:1903011)
0.0	0.0	GO:2000705	regulation of dense core granule biogenesis(GO:2000705)
0.0	0.1	GO:0048671	negative regulation of collateral sprouting(GO:0048671)
0.0	0.1	GO:0060576	intestinal epithelial cell development(GO:0060576)
0.0	0.1	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857)
0.0	0.1	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.4	GO:2001222	regulation of neuron migration(GO:2001222)
0.0	0.1	GO:0060903	positive regulation of meiosis I(GO:0060903)
0.0	0.0	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.1	GO:0007202	activation of phospholipase C activity(GO:0007202)
0.0	0.1	GO:0038031	non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.0	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661) negative regulation of mesodermal cell fate specification(GO:0042662)
0.0	0.1	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0035513	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0	0.3	GO:0021766	hippocampus development(GO:0021766)
0.0	0.0	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.3	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.0	0.1	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:2001275	positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0	0.0	GO:0002930	trabecular meshwork development(GO:0002930)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.2	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.0	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.0	GO:1903660	complement-dependent cytotoxicity(GO:0097278) regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.0	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.0	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.1	GO:1901552	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.1	GO:0060074	synapse maturation(GO:0060074)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.4	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.1	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.0	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.2	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.0	GO:0060847	endothelial cell fate specification(GO:0060847)
0.0	0.1	GO:0016926	protein desumoylation(GO:0016926)
0.0	0.0	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.0	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.1	GO:0031111	negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0	0.0	GO:1902302	potassium ion export across plasma membrane(GO:0097623) regulation of potassium ion export(GO:1902302)
0.0	0.0	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.1	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.1	GO:0031937	positive regulation of chromatin silencing(GO:0031937)
0.0	0.0	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.0	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.0	GO:0010624	regulation of Schwann cell proliferation(GO:0010624)
0.0	0.0	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.1	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.0	0.0	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.0	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.0	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.0	0.1	GO:0051560	mitochondrial calcium ion homeostasis(GO:0051560)
0.0	0.2	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.2	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.0	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.1	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0	0.1	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.0	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.0	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.1	GO:0097062	dendritic spine maintenance(GO:0097062)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:1902259	regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0	0.1	GO:0048245	eosinophil chemotaxis(GO:0048245)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.1	0.8	GO:0005859	muscle myosin complex(GO:0005859)
0.1	0.3	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.1	0.5	GO:0005915	zonula adherens(GO:0005915)
0.1	0.8	GO:0043194	axon initial segment(GO:0043194)
0.1	0.2	GO:0097443	sorting endosome(GO:0097443)
0.1	0.5	GO:0030314	junctional membrane complex(GO:0030314)
0.1	0.5	GO:0005861	troponin complex(GO:0005861)
0.1	0.2	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	0.3	GO:0045098	type III intermediate filament(GO:0045098)
0.1	0.3	GO:0005927	muscle tendon junction(GO:0005927)
0.1	0.3	GO:0045180	basal cortex(GO:0045180)
0.1	0.2	GO:0097452	GAIT complex(GO:0097452)
0.0	0.3	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.2	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.2	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	0.3	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.5	GO:0097449	astrocyte projection(GO:0097449)
0.0	0.4	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	3.8	GO:0031674	I band(GO:0031674)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.3	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.0	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.3	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.2	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.7	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.2	GO:0043203	axon hillock(GO:0043203)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0045261	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.2	GO:0071546	pi-body(GO:0071546)
0.0	0.1	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.5	GO:0032809	neuronal cell body membrane(GO:0032809)
0.0	0.2	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0072534	perineuronal net(GO:0072534)
0.0	0.0	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.3	GO:0043196	varicosity(GO:0043196)
0.0	0.8	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0	0.2	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.2	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0	0.1	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:0071953	elastic fiber(GO:0071953)
0.0	0.3	GO:0005922	connexon complex(GO:0005922)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0032280	symmetric synapse(GO:0032280)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.2	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0033648	host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0	0.1	GO:1990696	USH2 complex(GO:1990696)
0.0	0.8	GO:0030175	filopodium(GO:0030175)
0.0	0.3	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.6	GO:0044291	cell-cell contact zone(GO:0044291)
0.0	0.0	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.0	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.3	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.0	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.0	GO:0031430	M band(GO:0031430)
0.0	0.0	GO:1990393	3M complex(GO:1990393)
0.0	0.0	GO:0045251	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	1.0	GO:0005604	basement membrane(GO:0005604)
0.0	0.2	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.2	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.0	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.0	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0043293	apoptosome(GO:0043293)
0.0	1.4	GO:0031225	anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0004985	opioid receptor activity(GO:0004985)
0.2	0.6	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.2	0.5	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.2	0.7	GO:0031433	telethonin binding(GO:0031433)
0.2	0.5	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.2	0.5	GO:0035939	microsatellite binding(GO:0035939)
0.1	0.6	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	0.4	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.5	GO:0031014	troponin T binding(GO:0031014)
0.1	0.5	GO:0004111	creatine kinase activity(GO:0004111)
0.1	0.5	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.1	0.4	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.1	0.5	GO:0008517	folic acid transporter activity(GO:0008517)
0.1	0.2	GO:0016649	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1	0.3	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.4	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.1	0.2	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1	0.2	GO:0046538	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1	0.4	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.1	0.3	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1	0.8	GO:0005221	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1	0.3	GO:1990254	keratin filament binding(GO:1990254)
0.1	0.4	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1	0.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1	0.2	GO:0051373	FATZ binding(GO:0051373)
0.1	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	0.5	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.1	0.1	GO:0070546	L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1	0.2	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1	0.2	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	0.2	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1	0.2	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.1	0.3	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1	0.4	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	0.2	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.1	0.2	GO:0035851	Krueppel-associated box domain binding(GO:0035851)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.9	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.2	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.3	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.2	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.0	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.4	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.2	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.3	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.3	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	0.3	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.2	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.5	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0005326	neurotransmitter transporter activity(GO:0005326)
0.0	0.3	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.8	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.3	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.3	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.3	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.6	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.0	0.0	GO:0004096	catalase activity(GO:0004096)
0.0	0.0	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.3	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.3	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.0	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.0	GO:0034739	histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.6	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.2	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.5	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.4	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.4	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.0	GO:0004698	calcium-dependent protein kinase C activity(GO:0004698)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.2	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.6	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.0	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.0	0.3	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.2	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0	0.1	GO:0030546	receptor activator activity(GO:0030546)
0.0	0.1	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.0	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.0	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.0	0.1	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.0	0.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.0	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.2	GO:0031402	sodium ion binding(GO:0031402)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.0	GO:0052623	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	0.3	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	0.3	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.3	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.0	0.6	GO:0005518	collagen binding(GO:0005518)
0.0	0.2	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.0	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.1	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0043726	phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0	0.1	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.0	0.0	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.2	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.0	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0004970	ionotropic glutamate receptor activity(GO:0004970)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.3	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.7	PID RHOA PATHWAY	RhoA signaling pathway
0.5	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.2	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.2	PID INSULIN PATHWAY	Insulin Pathway
0.5	PID FGF PATHWAY	FGF signaling pathway
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.4	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID ALK2 PATHWAY	ALK2 signaling events
0.2	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	PID EPHB FWD PATHWAY	EPHB forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	0.8	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	0.2	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	1.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.5	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.4	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.5	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.5	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.1	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.0	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.7	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.2	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.0	0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	1.9	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.0	0.1	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.3	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.2	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.0	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.0	0.0	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.3	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	1.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.0	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0	0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.5	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.0	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.0	REACTOME CD28 CO STIMULATION	Genes involved in CD28 co-stimulation
0.0	0.1	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.1	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions

Results for Esrrg

Z-value: 0.54

Motif logo

Transcription factors associated with Esrrg

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Esrrg motif across conditions

Conditions sorted by the z-value of the Esrrg motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esrrg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: