Project
ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Etv6

Z-value: 0.50

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Transcription factors associated with Etv6

Gene Symbol Gene ID Gene Info
Etv6
ENSMUSG00000030199.10 Etv6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
Etv6chr6_134211159_134211530222560.149474-0.401.8e-03Click!
Etv6chr6_134035013_1340357473200.8999200.348.6e-03Click!
Etv6chr6_134042024_13404231161980.206162-0.302.0e-02Click!
Etv6chr6_134035835_1340363981470.9614280.292.7e-02Click!
Etv6chr6_134037752_13403790318580.355570-0.283.3e-02Click!

Activity of the Etv6 motif across conditions

Conditions sorted by the z-value of the Etv6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_78180060_78180244 1.09 Tlcd1
 TLC domain containing 1
 879
 0.2
chr5_125361044_125361231 1.08 Gm40323
 predicted gene, 40323
 38
 0.96
chr17_83808858_83809009 1.03 Mta3
 metastasis associated 3
 13511
 0.18
chr2_148680576_148680950 1.00 Gzf1
 GDNF-inducible zinc finger protein 1
 260
 0.9
chr11_5485603_5486347 0.98 Gm11962
 predicted gene 11962
 9471
 0.14
chr6_125009489_125010173 0.98 Zfp384
 zinc finger protein 384
 26
 0.94
chr7_45016836_45018032 0.91 Rras
 related RAS viral (r-ras) oncogene
 527
 0.43
chr11_95011480_95011953 0.88 Samd14
 sterile alpha motif domain containing 14
 1435
 0.27
chr8_122556522_122557920 0.88 Piezo1
 piezo-type mechanosensitive ion channel component 1
 5892
 0.1
chr19_53257195_53257790 0.84 1700001K23Rik
 RIKEN cDNA 1700001K23 gene
 2272
 0.25
chr1_45794912_45795350 0.78 Wdr75
 WD repeat domain 75
 35
 0.97
chr7_141209842_141210144 0.78 Lmntd2
 lamin tail domain containing 2
 4084
 0.08
chr15_80096554_80097109 0.76 Syngr1
 synaptogyrin 1
 1039
 0.33
chr15_83030057_83030676 0.75 Nfam1
 Nfat activating molecule with ITAM motif 1
 416
 0.79
chr7_28796055_28797204 0.74 Rinl
 Ras and Rab interactor-like
 309
 0.76
chr15_85811807_85811994 0.73 Cdpf1
 cysteine rich, DPF motif domain containing 1
 203
 0.91
chr1_180225593_180226807 0.71 Psen2
 presenilin 2
 3368
 0.18
chr14_55671318_55672155 0.71 Nedd8
 neural precursor cell expressed, developmentally down-regulated gene 8
 137
 0.55
chr7_105743752_105744690 0.70 Taf10
 TATA-box binding protein associated factor 10
 121
 0.91
chr4_115850002_115850153 0.70 Mknk1
 MAP kinase-interacting serine/threonine kinase 1
 6955
 0.13
chr6_87670319_87670941 0.69 E230015B07Rik
 RIKEN cDNA E230015B07 gene
 1353
 0.24
chr11_97511052_97512791 0.68 Gm11611
 predicted gene 11611
 9974
 0.12
chr11_77792865_77793937 0.67 Gm10277
 predicted gene 10277
 5654
 0.16
chr15_78877218_78878328 0.67 Gga1
 golgi associated, gamma adaptin ear containing, ARF binding protein 1
 222
 0.83
chr16_56037323_56037733 0.64 Trmt10c
 tRNA methyltransferase 10C, mitochondrial RNase P subunit
 291
 0.8
chr11_114668556_114669119 0.64 Rpl38
 ribosomal protein L38
 211
 0.92
chr15_97379421_97380753 0.63 Pced1b
 PC-esterase domain containing 1B
 18870
 0.24
chr15_78876971_78877162 0.61 Gga1
 golgi associated, gamma adaptin ear containing, ARF binding protein 1
 124
 0.9
chr4_98383218_98383435 0.61 Tm2d1
 TM2 domain containing 1
 20
 0.67
chr2_126932377_126933507 0.60 Sppl2a
 signal peptide peptidase like 2A
 293
 0.9
chr9_13245250_13245857 0.58 Jrkl
 Jrk-like
 276
 0.86
chr1_193172818_193173434 0.58 A130010J15Rik
 RIKEN cDNA A130010J15 gene
 342
 0.79
chr7_4149072_4149804 0.58 Leng9
 leukocyte receptor cluster (LRC) member 9
 936
 0.34
chr5_147860597_147861358 0.57 Pomp
 proteasome maturation protein
 324
 0.87
chr8_94182622_94183855 0.57 Gm39228
 predicted gene, 39228
 51
 0.95
chr9_20581003_20581881 0.56 Zfp846
 zinc finger protein 846
 83
 0.95
chr11_96915727_96916437 0.56 Cdk5rap3
 CDK5 regulatory subunit associated protein 3
 25
 0.69
chr5_123150083_123151176 0.55 Setd1b
 SET domain containing 1B
 7672
 0.08
chr17_35135244_35136480 0.55 Bag6
 BCL2-associated athanogene 6
 118
 0.84
chr12_13180713_13181236 0.54 Gm24208
 predicted gene, 24208
 17211
 0.16
chr12_37241627_37242172 0.54 Agmo
 alkylglycerol monooxygenase
 39
 0.99
chr7_127471033_127472292 0.53 Prr14
 proline rich 14
 172
 0.84
chr4_82858859_82859877 0.52 Zdhhc21
 zinc finger, DHHC domain containing 21
 186
 0.95
chr11_120098951_120099839 0.52 Ndufaf8
 NADH:ubiquinone oxidoreductase complex assembly factor 8
 296
 0.68
chr8_84977210_84978736 0.52 Junb
 jun B proto-oncogene
 745
 0.32
chr12_3235357_3235508 0.52 Rab10os
 RAB10, member RAS oncogene family, opposite strand
 72
 0.97
chr6_120364033_120365030 0.52 Kdm5a
 lysine (K)-specific demethylase 5A
 73
 0.62
chr2_132686926_132687263 0.52 Shld1
 shieldin complex subunit 1
 163
 0.92
chr2_181365439_181366324 0.50 Zgpat
 zinc finger, CCCH-type with G patch domain
 429
 0.44
chr18_68229517_68229916 0.48 Ldlrad4
 low density lipoprotein receptor class A domain containing 4
 1649
 0.37
chr6_56797213_56797748 0.48 Gm10209
 predicted gene 10209
 111
 0.63
chr11_58104070_58104840 0.48 Cnot8
 CCR4-NOT transcription complex, subunit 8
 89
 0.95
chr9_108490802_108491599 0.48 Usp19
 ubiquitin specific peptidase 19
 344
 0.67
chr11_48816327_48816915 0.48 Trim41
 tripartite motif-containing 41
 332
 0.76
chr17_86300838_86301701 0.48 2010106C02Rik
 RIKEN cDNA 2010106C02 gene
 14091
 0.27
chr5_146948357_146948548 0.47 Gtf3a
 general transcription factor III A
 205
 0.93
chr9_19622148_19622587 0.47 Zfp317
 zinc finger protein 317
 63
 0.96
chr17_21733400_21733702 0.47 Zfp229
 zinc finger protein 229
 129
 0.94
chr17_29263369_29264286 0.47 Ppil1
 peptidylprolyl isomerase (cyclophilin)-like 1
 111
 0.58
chr11_62005417_62006894 0.46 Specc1
 sperm antigen with calponin homology and coiled-coil domains 1
 805
 0.61
chr1_131136063_131136570 0.46 Dyrk3
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
 1929
 0.25
chr7_13033778_13034709 0.46 Chmp2a
 charged multivesicular body protein 2A
 401
 0.66
chr10_20952007_20952498 0.45 Ahi1
 Abelson helper integration site 1
 295
 0.92
chr8_110217965_110218603 0.45 Cmtr2
 cap methyltransferase 2
 295
 0.9
chr15_73156643_73156955 0.44 Ago2
 argonaute RISC catalytic subunit 2
 21048
 0.18
chr8_70139467_70139991 0.44 Borcs8
 BLOC-1 related complex subunit 8
 6
 0.47
chr4_133277237_133277725 0.43 Tmem222
 transmembrane protein 222
 137
 0.93
chr10_62327314_62328305 0.43 Hk1
 hexokinase 1
 42
 0.97
chr2_73058170_73058361 0.42 Gm13665
 predicted gene 13665
 58483
 0.09
chrX_42067935_42068524 0.42 Xiap
 X-linked inhibitor of apoptosis
 169
 0.96
chr9_70421677_70422108 0.42 Ccnb2
 cyclin B2
 345
 0.85
chr2_12419525_12419707 0.42 Mindy3
 MINDY lysine 48 deubiquitinase 3
 146
 0.94
chr4_125066307_125067492 0.41 Snip1
 Smad nuclear interacting protein 1
 197
 0.86
chr1_58505065_58505587 0.41 Gm15834
 predicted gene 15834
 171
 0.55
chr1_74600666_74601851 0.41 Rnf25
 ring finger protein 25
 87
 0.63
chr2_84714065_84715116 0.40 Zdhhc5
 zinc finger, DHHC domain containing 5
 96
 0.92
chr11_78031310_78031604 0.39 Dhrs13
 dehydrogenase/reductase (SDR family) member 13
 823
 0.34
chr9_46273030_46273181 0.39 Zpr1
 ZPR1 zinc finger
 41
 0.93
chr3_89430003_89431210 0.39 Pygo2
 pygopus 2
 134
 0.9
chr2_27539910_27541089 0.39 Gm13421
 predicted gene 13421
 70
 0.9
chr17_33915601_33916103 0.39 Tapbp
 TAP binding protein
 47
 0.48
chr16_78560111_78560350 0.39 D16Ertd472e
 DNA segment, Chr 16, ERATO Doi 472, expressed
 14
 0.56
chr13_41097843_41097994 0.39 Gm48344
 predicted gene, 48344
 6488
 0.13
chr8_70509737_70510396 0.39 Uba52
 ubiquitin A-52 residue ribosomal protein fusion product 1
 121
 0.9
chr11_44528978_44529659 0.38 Rnf145
 ring finger protein 145
 9013
 0.18
chr11_73137063_73138275 0.38 Haspin
 histone H3 associated protein kinase
 625
 0.6
chr3_127889422_127889573 0.38 Fam241a
 family with sequence similarity 241, member A
 6791
 0.13
chr11_45853066_45853434 0.37 Clint1
 clathrin interactor 1
 1286
 0.38
chr11_119392018_119392570 0.37 Rnf213
 ring finger protein 213
 806
 0.49
chr16_76365731_76366199 0.37 Nrip1
 nuclear receptor interacting protein 1
 7072
 0.21
chr3_54811140_54811438 0.37 Gm10254
 predicted gene 10254
 39
 0.97
chr10_128408634_128409894 0.36 Nabp2
 nucleic acid binding protein 2
 84
 0.9
chr15_99474673_99475009 0.36 Bcdin3d
 BCDIN3 domain containing
 111
 0.93
chr1_156523916_156524227 0.36 Csnk2a3
 casein kinase 2 alpha 3
 59
 0.97
chr11_78245687_78246240 0.35 Supt6
 SPT6, histone chaperone and transcription elongation factor
 24
 0.72
chr2_24386288_24387076 0.35 Psd4
 pleckstrin and Sec7 domain containing 4
 65
 0.97
chr12_105784740_105785770 0.35 Papola
 poly (A) polymerase alpha
 383
 0.86
chr3_157533826_157535237 0.35 Zranb2
 zinc finger, RAN-binding domain containing 2
 106
 0.84
chr2_132253346_132253893 0.35 AV099323
 expressed sequence AV099323
 262
 0.53
chr11_26591574_26591760 0.35 Vrk2
 vaccinia related kinase 2
 62
 0.97
chr19_45005673_45006396 0.35 Twnk
 twinkle mtDNA helicase
 371
 0.45
chr6_141488896_141489047 0.34 Slco1c1
 solute carrier organic anion transporter family, member 1c1
 35397
 0.18
chr14_55094784_55095911 0.34 Thtpa
 thiamine triphosphatase
 563
 0.54
chr2_75937843_75939119 0.34 Ttc30b
 tetratricopeptide repeat domain 30B
 104
 0.96
chr4_88878434_88878641 0.34 Ifne
 interferon epsilon
 1664
 0.16
chr19_3282559_3283552 0.33 Mrpl21
 mitochondrial ribosomal protein L21
 0
 0.51
chr11_69914045_69915024 0.33 Gps2
 G protein pathway suppressor 2
 311
 0.67
chr14_52279628_52280152 0.33 Tox4
 TOX high mobility group box family member 4
 158
 0.69
chr15_5185304_5185980 0.33 Gm15938
 predicted gene 15938
 81
 0.49
chr6_136793393_136794589 0.33 H4f16
 H4 histone 16
 10424
 0.09
chrX_134541627_134541952 0.32 Timm8a1
 translocase of inner mitochondrial membrane 8A1
 76
 0.95
chr4_31963905_31964773 0.32 Map3k7
 mitogen-activated protein kinase kinase kinase 7
 76
 0.98
chr17_47010961_47011192 0.32 Ubr2
 ubiquitin protein ligase E3 component n-recognin 2
 520
 0.76
chr5_22612995_22613241 0.32 Rpl17-ps5
 ribosomal protein L17, pseudogene 5
 64
 0.97
chr2_136890459_136890749 0.32 Mkks
 McKusick-Kaufman syndrome
 550
 0.38
chr7_39449138_39450316 0.31 Zfp939
 zinc finger protein 939
 209
 0.75
chr13_21362484_21362864 0.31 Zscan12
 zinc finger and SCAN domain containing 12
 146
 0.9
chr14_101639989_101640746 0.31 Commd6
 COMM domain containing 6
 81
 0.97
chr17_56256141_56256492 0.31 Fem1a
 fem 1 homolog a
 494
 0.62
chr3_150515944_150516241 0.31 Gm6439
 predicted gene 6439
 11
 0.99
chr12_76362328_76362736 0.30 Zbtb25
 zinc finger and BTB domain containing 25
 5392
 0.11
chr19_6910112_6910674 0.30 Trmt112
 tRNA methyltransferase 11-2
 229
 0.52
chr7_100492685_100494805 0.30 Ucp2
 uncoupling protein 2 (mitochondrial, proton carrier)
 50
 0.95
chr14_55064836_55065251 0.30 Zfhx2
 zinc finger homeobox 2
 7191
 0.08
chr6_125152493_125152726 0.30 Iffo1
 intermediate filament family orphan 1
 739
 0.38
chr19_46135570_46137235 0.30 Pitx3
 paired-like homeodomain transcription factor 3
 887
 0.45
chr6_119481820_119482341 0.30 Fbxl14
 F-box and leucine-rich repeat protein 14
 2412
 0.3
chr7_16416809_16416960 0.29 Gm45510
 predicted gene 45510
 263
 0.82
chr1_134494702_134495438 0.29 Rabif
 RAB interacting factor
 422
 0.72
chr16_21333322_21333876 0.29 Magef1
 melanoma antigen family F, 1
 243
 0.93
chr7_25718309_25719059 0.29 Ccdc97
 coiled-coil domain containing 97
 307
 0.8
chr11_84867576_84868235 0.29 Ggnbp2
 gametogenetin binding protein 2
 2297
 0.18
chrX_50566542_50567054 0.29 Firre
 functional intergenic repeating RNA element
 1915
 0.4
chr15_59317788_59318646 0.28 Sqle
 squalene epoxidase
 3110
 0.21
chrX_142389571_142390415 0.28 Acsl4
 acyl-CoA synthetase long-chain family member 4
 351
 0.84
chr6_128424733_128425194 0.28 Itfg2
 integrin alpha FG-GAP repeat containing 2
 32
 0.94
chr3_95436992_95437143 0.28 Arnt
 aryl hydrocarbon receptor nuclear translocator
 2548
 0.14
chr7_45434237_45434647 0.28 Ruvbl2
 RuvB-like protein 2
 165
 0.68
chr12_108791850_108792666 0.27 Gm34220
 predicted gene, 34220
 485
 0.52
chr5_146692514_146692846 0.27 4930573C15Rik
 RIKEN cDNA 4930573C15 gene
 13942
 0.17
chr2_180041752_180042359 0.27 Psma7
 proteasome subunit alpha 7
 330
 0.56
chr8_105225257_105225974 0.27 D230025D16Rik
 RIKEN cDNA D230025D16 gene
 348
 0.74
chr9_50658697_50660266 0.27 Dlat
 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
 299
 0.84
chr8_11009176_11009974 0.26 Irs2
 insulin receptor substrate 2
 1117
 0.36
chr14_52196647_52197712 0.26 Supt16
 SPT16, facilitates chromatin remodeling subunit
 237
 0.56
chr4_32799944_32801043 0.26 Lyrm2
 LYR motif containing 2
 211
 0.94
chr6_147042566_147042769 0.26 Mrps35
 mitochondrial ribosomal protein S35
 97
 0.95
chr3_95871268_95871981 0.26 C920021L13Rik
 RIKEN cDNA C920021L13 gene
 93
 0.5
chr7_4865726_4866166 0.25 Isoc2b
 isochorismatase domain containing 2b
 222
 0.84
chr2_180545211_180545584 0.25 Mrgbp
 MRG/MORF4L binding protein
 35907
 0.1
chr12_84970237_84970929 0.25 Arel1
 apoptosis resistant E3 ubiquitin protein ligase 1
 241
 0.56
chr17_15395813_15397019 0.25 Fam120b
 family with sequence similarity 120, member B
 168
 0.94
chr5_25529908_25530568 0.24 1700096K18Rik
 RIKEN cDNA 1700096K18 gene
 225
 0.88
chr8_126591197_126592184 0.24 Irf2bp2
 interferon regulatory factor 2 binding protein 2
 2296
 0.34
chr15_99701831_99703358 0.24 Smarcd1
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
 0
 0.93
chrX_56156268_56156478 0.24 Gm14639
 predicted gene 14639
 20
 0.97
chr7_45922758_45923210 0.24 Ccdc114
 coiled-coil domain containing 114
 1088
 0.21
chr13_36117883_36118106 0.24 Fars2
 phenylalanine-tRNA synthetase 2 (mitochondrial)
 114
 0.84
chr7_44853717_44855163 0.24 Akt1s1
 AKT1 substrate 1 (proline-rich)
 1869
 0.12
chr5_140387535_140387686 0.23 Snx8
 sorting nexin 8
 1631
 0.28
chr5_115559545_115560657 0.23 Rplp0
 ribosomal protein, large, P0
 478
 0.66
chr7_29859641_29859994 0.23 Zfp420
 zinc finger protein 420
 162
 0.89
chr9_72791719_72792022 0.23 Prtg
 protogenin
 15004
 0.11
chr9_62979878_62980820 0.23 Pias1
 protein inhibitor of activated STAT 1
 530
 0.8
chr1_57970048_57970402 0.23 Kctd18
 potassium channel tetramerisation domain containing 18
 97
 0.97
chr9_107571266_107571916 0.23 Hyal2
 hyaluronoglucosaminidase 2
 381
 0.57
chr11_117344543_117345735 0.23 Septin9
 septin 9
 8041
 0.2
chr5_134183780_134184412 0.23 Gtf2ird2
 GTF2I repeat domain containing 2
 69
 0.96
chr2_167656344_167657144 0.23 Gm20431
 predicted gene 20431
 4752
 0.11
chr9_96891577_96891728 0.23 Pxylp1
 2-phosphoxylose phosphatase 1
 438
 0.78
chr10_44852553_44852796 0.22 Gm6983
 predicted gene 6983
 60
 0.97
chr4_116073957_116074118 0.22 Uqcrh
 ubiquinol-cytochrome c reductase hinge protein
 994
 0.31
chr7_80947492_80948211 0.22 Sec11a
 SEC11 homolog A, signal peptidase complex subunit
 71
 0.95
chr2_30061841_30063386 0.22 Set
 SET nuclear oncogene
 12
 0.96
chr2_119115391_119115542 0.22 Rad51
 RAD51 recombinase
 2649
 0.18
chr15_5116689_5117882 0.22 Rpl37
 ribosomal protein L37
 1
 0.94
chrX_50590880_50591432 0.22 Firre
 functional intergenic repeating RNA element
 803
 0.72
chr7_126474488_126475011 0.22 Sh2b1
 SH2B adaptor protein 1
 73
 0.94
chr4_124714467_124714687 0.22 Sf3a3
 splicing factor 3a, subunit 3
 199
 0.86
chr17_35969746_35970067 0.21 Abcf1
 ATP-binding cassette, sub-family F (GCN20), member 1
 145
 0.86
chrX_57325690_57326987 0.21 Arhgef6
 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
 261
 0.93
chr8_83998330_83998685 0.21 Samd1
 sterile alpha motif domain containing 1
 83
 0.91
chr8_124899499_124899768 0.21 Gm45709
 predicted gene 45709
 497
 0.62
chr8_46470840_46472147 0.21 Acsl1
 acyl-CoA synthetase long-chain family member 1
 310
 0.85
chr15_98144892_98145974 0.21 Asb8
 ankyrin repeat and SOCS box-containing 8
 226
 0.89
chr13_4191088_4191744 0.21 Akr1c13
 aldo-keto reductase family 1, member C13
 232
 0.89
chr2_119112294_119112797 0.21 Rad51
 RAD51 recombinase
 248
 0.88
chr5_120116535_120116888 0.21 Rbm19
 RNA binding motif protein 19
 191
 0.95
chr19_6856906_6858230 0.21 Ccdc88b
 coiled-coil domain containing 88B
 643
 0.54
chr1_156035357_156035647 0.21 Tor1aip2
 torsin A interacting protein 2
 99
 0.87
chr11_70763963_70764993 0.21 Zfp3
 zinc finger protein 3
 269
 0.79
chr10_82984904_82986571 0.21 Chst11
 carbohydrate sulfotransferase 11
 239
 0.93
chr14_32513251_32514390 0.20 Ercc6
 excision repair cross-complementing rodent repair deficiency, complementation group 6
 290
 0.89
chr3_28171238_28171870 0.20 Gm42196
 predicted gene, 42196
 4999
 0.26
chr14_51064866_51065193 0.20 Olfr750
 olfactory receptor 750
 6413
 0.08
chr14_24487009_24487267 0.20 Rps24
 ribosomal protein S24
 13
 0.55
chr17_36270914_36272068 0.20 Trim39
 tripartite motif-containing 39
 76
 0.91
chr17_28234245_28235051 0.20 Ppard
 peroxisome proliferator activator receptor delta
 1841
 0.22
chr8_125013082_125013762 0.20 Tsnax
 translin-associated factor X
 373
 0.83
chr2_167421218_167421702 0.20 Slc9a8
 solute carrier family 9 (sodium/hydrogen exchanger), member 8
 252
 0.92

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of Etv6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0036506 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.5 GO:0000966 RNA 5'-end processing(GO:0000966)
0.1 0.4 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.1 0.4 GO:0030576 Cajal body organization(GO:0030576)
0.1 0.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.5 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.4 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.3 GO:0061511 centriole elongation(GO:0061511)
0.1 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.6 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.3 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1 0.2 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1 0.4 GO:0080009 mRNA methylation(GO:0080009)
0.1 0.4 GO:0061620 glycolytic process through glucose-6-phosphate(GO:0061620)
0.1 0.1 GO:0043096 purine nucleobase salvage(GO:0043096)
0.1 0.2 GO:0042723 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.1 0.6 GO:0048318 axial mesoderm development(GO:0048318)
0.1 0.6 GO:0070365 hepatocyte differentiation(GO:0070365)
0.1 0.2 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 0.3 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.1 0.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 0.4 GO:0071569 protein ufmylation(GO:0071569)
0.1 0.2 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.2 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.3 GO:1901026 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1 0.3 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 0.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.1 0.3 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.1 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.2 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1 0.5 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.0 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.2 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0042117 monocyte activation(GO:0042117)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.6 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.1 GO:0046149 heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.1 GO:0034635 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0 0.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.0 0.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.4 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0071332 cellular response to fructose stimulus(GO:0071332)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0070200 establishment of protein localization to telomere(GO:0070200)
0.0 0.1 GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 1.1 GO:1901998 toxin transport(GO:1901998)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0051256 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0 0.2 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0033122 negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0 0.3 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 0.1 GO:0031506 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.9 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.5 GO:0070918 dsRNA fragmentation(GO:0031050) production of miRNAs involved in gene silencing by miRNA(GO:0035196) production of small RNA involved in gene silencing by RNA(GO:0070918)
0.0 0.1 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
0.0 0.1 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0 0.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.4 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.1 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.0 GO:2000630 positive regulation of miRNA metabolic process(GO:2000630)
0.0 0.1 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.1 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.0 GO:0010835 regulation of protein ADP-ribosylation(GO:0010835)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.0 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.1 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.0 GO:1905216 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 0.0 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.0 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.0 GO:0019086 late viral transcription(GO:0019086)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.0 GO:1905063 regulation of vascular smooth muscle cell differentiation(GO:1905063)
0.0 0.2 GO:0035357 peroxisome proliferator activated receptor signaling pathway(GO:0035357)
0.0 0.1 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.0 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.1 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.0 GO:0061156 pulmonary artery morphogenesis(GO:0061156)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.0 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:0033127 regulation of histone phosphorylation(GO:0033127)
0.0 0.1 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.3 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 0.2 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.0 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.4 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.0 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.0 0.1 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.1 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.0 0.6 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.0 0.0 GO:0033578 protein glycosylation in Golgi(GO:0033578)
0.0 0.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0048538 thymus development(GO:0048538)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0000125 PCAF complex(GO:0000125)
0.2 0.5 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.4 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.5 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.1 0.3 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.2 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0035363 histone locus body(GO:0035363)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0008278 cohesin complex(GO:0008278)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0001939 female pronucleus(GO:0001939)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.0 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.2 GO:0016428 tRNA (cytosine) methyltransferase activity(GO:0016427) tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.1 0.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.2 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.2 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.2 GO:0046978 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.1 0.2 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.1 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.5 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.1 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.1 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.5 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.2 GO:0018449 pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.8 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.0 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.0 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.0 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.1 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.0 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 1.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0045543 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.0 0.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 0.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.1 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.3 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.0 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.0 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.1 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis