Project
ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Figla

Z-value: 0.31

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Transcription factors associated with Figla

Gene Symbol Gene ID Gene Info
Figla
ENSMUSG00000030001.3 Figla

Activity of the Figla motif across conditions

Conditions sorted by the z-value of the Figla motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_16100111_16100955 0.48 Napa
 N-ethylmaleimide sensitive fusion protein attachment protein alpha
 1895
 0.23
chr11_96946068_96946479 0.48 D030028A08Rik
 RIKEN cDNA D030028A08 gene
 1961
 0.15
chr4_133872481_133873035 0.47 Gm12977
 predicted gene 12977
 276
 0.47
chr11_102357545_102358717 0.44 Slc4a1
 solute carrier family 4 (anion exchanger), member 1
 2437
 0.16
chr5_134915097_134915436 0.36 Cldn13
 claudin 13
 260
 0.81
chr12_105038279_105038596 0.35 Glrx5
 glutaredoxin 5
 3221
 0.13
chr11_11732922_11733382 0.35 Gm12000
 predicted gene 12000
 36713
 0.13
chr17_57234704_57235202 0.31 C3
 complement component 3
 6817
 0.11
chr18_32555746_32555897 0.29 Gypc
 glycophorin C
 4159
 0.24
chr8_94169527_94169694 0.29 Mt2
 metallothionein 2
 3054
 0.13
chr5_113973724_113975031 0.27 Ssh1
 slingshot protein phosphatase 1
 7621
 0.13
chr12_105034788_105035573 0.27 Glrx5
 glutaredoxin 5
 36
 0.95
chr9_120114964_120115764 0.26 Slc25a38
 solute carrier family 25, member 38
 375
 0.69
chr9_64807169_64807758 0.25 Dennd4a
 DENN/MADD domain containing 4A
 3877
 0.25
chr13_73468941_73470244 0.25 Lpcat1
 lysophosphatidylcholine acyltransferase 1
 2159
 0.35
chr4_87881641_87881792 0.25 Mllt3
 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
 7174
 0.3
chr10_58373981_58374132 0.25 Lims1
 LIM and senescent cell antigen-like domains 1
 2602
 0.27
chr13_9095816_9096692 0.24 Larp4b
 La ribonucleoprotein domain family, member 4B
 2272
 0.25
chr3_127893429_127894301 0.24 Fam241a
 family with sequence similarity 241, member A
 2423
 0.2
chr15_80743676_80743993 0.24 Gm49512
 predicted gene, 49512
 31563
 0.13
chr11_102363631_102364272 0.24 Slc4a1
 solute carrier family 4 (anion exchanger), member 1
 247
 0.85
chr6_86547683_86548400 0.23 1600020E01Rik
 RIKEN cDNA 1600020E01 gene
 60
 0.95
chr7_127090806_127091953 0.22 AI467606
 expressed sequence AI467606
 20
 0.93
chr14_75178051_75179727 0.22 Lcp1
 lymphocyte cytosolic protein 1
 2681
 0.23
chr5_143819014_143819653 0.22 Eif2ak1
 eukaryotic translation initiation factor 2 alpha kinase 1
 1386
 0.38
chr15_83169748_83171160 0.22 Cyb5r3
 cytochrome b5 reductase 3
 52
 0.95
chr16_91804661_91805209 0.22 Itsn1
 intersectin 1 (SH3 domain protein 1A)
 299
 0.9
chr7_121073211_121073362 0.22 Igsf6
 immunoglobulin superfamily, member 6
 1286
 0.24
chr2_109281814_109282372 0.22 Kif18a
 kinesin family member 18A
 1224
 0.4
chr12_84150828_84152588 0.22 Pnma1
 paraneoplastic antigen MA1
 3219
 0.13
chr8_105300231_105300842 0.21 E2f4
 E2F transcription factor 4
 2819
 0.08
chr2_93455051_93455258 0.20 Gm10804
 predicted gene 10804
 2333
 0.24
chr12_103656514_103657055 0.20 Serpina6
 serine (or cysteine) peptidase inhibitor, clade A, member 6
 318
 0.81
chr11_4122925_4123415 0.20 Sec14l2
 SEC14-like lipid binding 2
 245
 0.83
chr3_83008148_83008803 0.20 Gm30097
 predicted gene, 30097
 13
 0.92
chr6_57754218_57754905 0.20 Lancl2
 LanC (bacterial lantibiotic synthetase component C)-like 2
 51474
 0.08
chr8_88298512_88298878 0.19 Adcy7
 adenylate cyclase 7
 1684
 0.37
chrX_101275149_101275321 0.19 Med12
 mediator complex subunit 12
 975
 0.34
chr1_80030817_80031190 0.19 Gm28058
 predicted gene 28058
 67619
 0.09
chr2_45055787_45056274 0.19 Zeb2
 zinc finger E-box binding homeobox 2
 1789
 0.4
chr10_81351824_81352381 0.19 Hmg20b
 high mobility group 20B
 1622
 0.13
chr3_146407041_146407816 0.19 Ssx2ip
 synovial sarcoma, X 2 interacting protein
 2450
 0.2
chr2_163547257_163548345 0.19 Hnf4a
 hepatic nuclear factor 4, alpha
 613
 0.63
chr17_79926076_79926433 0.19 Gm6552
 predicted gene 6552
 8318
 0.18
chr9_63760744_63760895 0.19 Smad3
 SMAD family member 3
 2825
 0.3
chr4_46396091_46396440 0.18 Trmo
 tRNA methyltransferase O
 6828
 0.13
chr1_45872040_45872606 0.18 Gm5526
 predicted pseudogene 5526
 14569
 0.12
chr4_6194375_6194526 0.18 Ubxn2b
 UBX domain protein 2B
 3352
 0.3
chr7_132778272_132778793 0.18 Fam53b
 family with sequence similarity 53, member B
 1616
 0.39
chr18_64504795_64505332 0.18 Nars
 asparaginyl-tRNA synthetase
 13
 0.97
chr17_46159788_46160011 0.18 Gtpbp2
 GTP binding protein 2
 1133
 0.32
chr6_127578287_127578988 0.18 Cracr2a
 calcium release activated channel regulator 2A
 662
 0.73
chr12_81028018_81028551 0.18 Smoc1
 SPARC related modular calcium binding 1
 1456
 0.42
chr10_40149812_40150388 0.18 Slc16a10
 solute carrier family 16 (monocarboxylic acid transporters), member 10
 7842
 0.13
chr3_51416101_51417305 0.17 Naa15
 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
 89
 0.94
chr9_108083459_108083743 0.17 Rnf123
 ring finger protein 123
 255
 0.67
chr15_57891181_57891332 0.17 Derl1
 Der1-like domain family, member 1
 862
 0.63
chr6_118757250_118757706 0.17 Cacna1c
 calcium channel, voltage-dependent, L type, alpha 1C subunit
 496
 0.86
chr17_71206427_71206897 0.17 Lpin2
 lipin 2
 1986
 0.3
chr15_80744676_80744939 0.17 Gm49512
 predicted gene, 49512
 32536
 0.13
chr7_45522122_45522472 0.16 Ppp1r15a
 protein phosphatase 1, regulatory subunit 15A
 1472
 0.15
chr6_29698375_29698642 0.16 Tspan33
 tetraspanin 33
 4274
 0.2
chr15_86104572_86104788 0.16 Gm15722
 predicted gene 15722
 14620
 0.17
chr13_91461118_91462460 0.16 Ssbp2
 single-stranded DNA binding protein 2
 608
 0.81
chr19_39739090_39739575 0.16 Cyp2c68
 cytochrome P450, family 2, subfamily c, polypeptide 68
 1722
 0.45
chr12_76256073_76256502 0.16 Mthfd1
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
 807
 0.38
chr4_43612409_43612615 0.16 Gm25262
 predicted gene, 25262
 18913
 0.06
chr12_75320470_75320850 0.16 Rhoj
 ras homolog family member J
 11779
 0.27
chr6_38920967_38921907 0.16 Tbxas1
 thromboxane A synthase 1, platelet
 2413
 0.31
chr13_45546862_45547471 0.16 Gmpr
 guanosine monophosphate reductase
 1013
 0.64
chr18_67241729_67242343 0.16 Mppe1
 metallophosphoesterase 1
 3241
 0.19
chr17_84180639_84182724 0.16 Gm36279
 predicted gene, 36279
 4075
 0.18
chr8_105941562_105942262 0.16 Lcat
 lecithin cholesterol acyltransferase
 1470
 0.16
chr2_170427280_170427591 0.16 Bcas1
 breast carcinoma amplified sequence 1
 393
 0.83
chr4_139335404_139335655 0.16 AL807811.1
 aldo-keto reductase family 7 member A2 (AKR7A2) pseudogene
 1651
 0.17
chr2_84738253_84739261 0.16 Mir130a
 microRNA 130a
 2421
 0.12
chr17_27558079_27558612 0.16 Hmga1
 high mobility group AT-hook 1
 1650
 0.16
chr16_90987984_90989157 0.16 Gm15965
 predicted gene 15965
 4663
 0.12
chr13_51647699_51648388 0.16 Gm22806
 predicted gene, 22806
 156
 0.94
chr10_53598517_53599274 0.16 Asf1a
 anti-silencing function 1A histone chaperone
 1138
 0.28
chr6_120819964_120820819 0.16 Atp6v1e1
 ATPase, H+ transporting, lysosomal V1 subunit E1
 1992
 0.25
chr7_75863523_75863976 0.15 Klhl25
 kelch-like 25
 15308
 0.22
chr15_80079782_80080738 0.15 Gm22077
 predicted gene, 22077
 83
 0.67
chr8_122719956_122721464 0.15 C230057M02Rik
 RIKEN cDNA C230057M02 gene
 17801
 0.09
chr5_66080287_66081072 0.15 Rbm47
 RNA binding motif protein 47
 305
 0.84
chr18_84884692_84885054 0.15 Cyb5a
 cytochrome b5 type A (microsomal)
 7272
 0.17
chr11_55468160_55468311 0.15 G3bp1
 GTPase activating protein (SH3 domain) binding protein 1
 1450
 0.26
chr10_81376905_81377216 0.15 Fzr1
 fizzy and cell division cycle 20 related 1
 1320
 0.16
chr4_118568999_118569601 0.15 Tmem125
 transmembrane protein 125
 25256
 0.1
chr17_48466649_48466831 0.15 Unc5cl
 unc-5 family C-terminal like
 4336
 0.16
chr19_55939739_55939984 0.15 Tcf7l2
 transcription factor 7 like 2, T cell specific, HMG box
 41552
 0.17
chr10_80117771_80117922 0.15 Stk11
 serine/threonine kinase 11
 1492
 0.21
chr13_21751920_21752638 0.15 Gm44454
 predicted gene, 44454
 1166
 0.14
chr2_4572310_4572962 0.15 Frmd4a
 FERM domain containing 4A
 6460
 0.21
chr11_78832870_78833569 0.15 Lyrm9
 LYR motif containing 9
 6590
 0.18
chr12_76907283_76907638 0.15 Fntb
 farnesyltransferase, CAAX box, beta
 2026
 0.3
chr8_107586529_107586949 0.14 Psmd7
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
 1719
 0.37
chr6_83056416_83056567 0.14 Aup1
 ancient ubiquitous protein 1
 21
 0.89
chrX_9748838_9749171 0.14 Dynlt3
 dynein light chain Tctex-type 3
 86001
 0.08
chr17_5492680_5493910 0.14 Zdhhc14
 zinc finger, DHHC domain containing 14
 738
 0.66
chr12_24892833_24893055 0.14 Mboat2
 membrane bound O-acyltransferase domain containing 2
 61313
 0.09
chr5_22342338_22343153 0.14 Reln
 reelin
 1945
 0.26
chr18_56922535_56922923 0.14 Marchf3
 membrane associated ring-CH-type finger 3
 2786
 0.27
chr15_80257680_80258950 0.14 Atf4
 activating transcription factor 4
 2792
 0.15
chr13_3863108_3863464 0.14 Calm5
 calmodulin 5
 9018
 0.12
chr19_6300669_6301196 0.14 Ehd1
 EH-domain containing 1
 3018
 0.1
chr8_120490793_120490944 0.14 Gse1
 genetic suppressor element 1, coiled-coil protein
 2421
 0.23
chr2_181286147_181286410 0.14 Gmeb2
 glucocorticoid modulatory element binding protein 2
 796
 0.45
chr9_106156833_106157412 0.14 Glyctk
 glycerate kinase
 128
 0.86
chr11_78180253_78181436 0.14 Snord42a
 small nucleolar RNA, C/D box 42A
 519
 0.33
chr5_27790098_27791663 0.13 Paxip1
 PAX interacting (with transcription-activation domain) protein 1
 503
 0.77
chr4_141751491_141751738 0.13 Agmat
 agmatine ureohydrolase (agmatinase)
 4942
 0.14
chr10_111476556_111477031 0.13 Nap1l1
 nucleosome assembly protein 1-like 1
 3512
 0.17
chr11_60942458_60942611 0.13 Map2k3
 mitogen-activated protein kinase kinase 3
 654
 0.63
chr2_118658075_118658340 0.13 Pak6
 p21 (RAC1) activated kinase 6
 5096
 0.16
chr9_72408510_72409012 0.13 Gm27255
 predicted gene 27255
 507
 0.52
chr5_146891291_146891493 0.13 Rasl11a
 RAS-like, family 11, member A
 45627
 0.09
chr11_6295096_6295368 0.13 Ogdh
 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
 2627
 0.17
chr7_141392818_141393024 0.13 Taldo1
 transaldolase 1
 678
 0.42
chr11_52076244_52076395 0.13 Ppp2ca
 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
 22362
 0.11
chr4_134869303_134870057 0.13 Rhd
 Rh blood group, D antigen
 5144
 0.18
chr8_122698741_122699314 0.13 Cbfa2t3
 CBFA2/RUNX1 translocation partner 3
 82
 0.93
chr11_95805344_95805600 0.13 Phospho1
 phosphatase, orphan 1
 19027
 0.1
chr13_73474220_73474371 0.13 Lpcat1
 lysophosphatidylcholine acyltransferase 1
 2544
 0.32
chr8_69901818_69903173 0.13 Ndufa13
 NADH:ubiquinone oxidoreductase subunit A13
 63
 0.61
chr4_63561098_63561515 0.13 Tmem268
 transmembrane protein 268
 946
 0.42
chr2_161066341_161066692 0.13 Chd6
 chromodomain helicase DNA binding protein 6
 13938
 0.19
chr10_75882493_75882971 0.12 Gm47744
 predicted gene, 47744
 7301
 0.09
chr5_28457868_28460972 0.12 9530036O11Rik
 RIKEN cDNA 9530036O11Rik
 1146
 0.51
chr1_134221026_134221177 0.12 Adora1
 adenosine A1 receptor
 13477
 0.13
chr5_30668984_30669165 0.12 Cenpa
 centromere protein A
 2076
 0.22
chr2_105125289_105128976 0.12 Wt1
 Wilms tumor 1 homolog
 78
 0.91
chr13_45507294_45508710 0.12 Gmpr
 guanosine monophosphate reductase
 558
 0.8
chr6_67035838_67036542 0.12 E230016M11Rik
 RIKEN cDNA E230016M11 gene
 409
 0.66
chr7_142995964_142996137 0.12 Tspan32os
 tetraspanin 32, opposite strand
 5272
 0.14
chr17_26199126_26199427 0.12 Pdia2
 protein disulfide isomerase associated 2
 189
 0.84
chr1_179853722_179853937 0.12 Ahctf1
 AT hook containing transcription factor 1
 50149
 0.12
chr9_106888249_106888666 0.12 Rbm15b
 RNA binding motif protein 15B
 1029
 0.34
chr17_71183626_71184775 0.12 Lpin2
 lipin 2
 222
 0.92
chr3_88500857_88501223 0.12 Lmna
 lamin A
 2267
 0.13
chr9_72448745_72450029 0.12 Gm27231
 predicted gene 27231
 7608
 0.08
chr9_71484793_71485892 0.12 Polr2m
 polymerase (RNA) II (DNA directed) polypeptide M
 384
 0.9
chr15_73179775_73180371 0.12 Ago2
 argonaute RISC catalytic subunit 2
 2226
 0.31
chrX_13202535_13203215 0.12 Rpl3-ps1
 ribosomal protein L3, pseudogene 1
 304
 0.82
chr2_26474742_26475391 0.12 Notch1
 notch 1
 4568
 0.11
chr3_90429599_90429750 0.12 Ints3
 integrator complex subunit 3
 3629
 0.12
chr18_84854906_84855693 0.11 Cyb5a
 cytochrome b5 type A (microsomal)
 330
 0.86
chr1_6730862_6731309 0.11 St18
 suppression of tumorigenicity 18
 983
 0.68
chr1_52231983_52233150 0.11 Gls
 glutaminase
 245
 0.93
chr1_20818287_20818966 0.11 Mcm3
 minichromosome maintenance complex component 3
 1634
 0.25
chr2_119619277_119620230 0.11 Nusap1
 nucleolar and spindle associated protein 1
 1024
 0.3
chr10_80859175_80859326 0.11 Sppl2b
 signal peptide peptidase like 2B
 2129
 0.13
chr13_99754101_99754292 0.11 Gm24471
 predicted gene, 24471
 61667
 0.12
chr17_25225774_25226523 0.11 Unkl
 unkempt family like zinc finger
 3369
 0.1
chr3_88953114_88953265 0.11 Dap3
 death associated protein 3
 2008
 0.18
chr1_180817810_180817961 0.11 H3f3a
 H3.3 histone A
 3942
 0.12
chr14_31431914_31432260 0.11 Sh3bp5
 SH3-domain binding protein 5 (BTK-associated)
 3978
 0.17
chr5_64807638_64809344 0.11 Klf3
 Kruppel-like factor 3 (basic)
 3848
 0.17
chr14_31260741_31261456 0.11 Bap1
 Brca1 associated protein 1
 3607
 0.12
chr9_110699580_110699731 0.11 Ccdc12
 coiled-coil domain containing 12
 10239
 0.11
chr17_49429375_49429751 0.11 Gm20540
 predicted gene 20540
 323
 0.83
chr11_69254981_69255132 0.11 Gm23194
 predicted gene, 23194
 14457
 0.09
chr10_127730237_127730758 0.11 Tac2
 tachykinin 2
 2650
 0.12
chr17_32117457_32118702 0.11 Gm17276
 predicted gene, 17276
 4332
 0.15
chr14_8258997_8259161 0.11 Acox2
 acyl-Coenzyme A oxidase 2, branched chain
 247
 0.93
chr2_174296925_174297566 0.11 Gnas
 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
 614
 0.6
chr4_125727107_125727874 0.11 2610028E06Rik
 RIKEN cDNA 2610028E06 gene
 171492
 0.03
chr13_98890050_98891071 0.11 Tnpo1
 transportin 1
 438
 0.78
chr4_141161340_141161491 0.11 Fbxo42
 F-box protein 42
 13493
 0.11
chr13_95698558_95698709 0.11 F2rl2
 coagulation factor II (thrombin) receptor-like 2
 1780
 0.27
chr16_24199309_24199754 0.11 Gm31814
 predicted gene, 31814
 16715
 0.19
chr18_88758573_88758778 0.11 Socs6
 suppressor of cytokine signaling 6
 184
 0.96
chr11_44528978_44529659 0.11 Rnf145
 ring finger protein 145
 9013
 0.18
chr7_128689234_128689975 0.11 Gm43580
 predicted gene 43580
 1069
 0.26
chr19_7240047_7241153 0.11 Naa40
 N(alpha)-acetyltransferase 40, NatD catalytic subunit
 434
 0.7
chr4_108961053_108961426 0.11 8030443G20Rik
 RIKEN cDNA 8030443G20 gene
 10838
 0.13
chr13_49306649_49306800 0.11 Fgd3
 FYVE, RhoGEF and PH domain containing 3
 2516
 0.28
chr4_126260482_126261460 0.11 Trappc3
 trafficking protein particle complex 3
 1354
 0.3
chr15_89607900_89608068 0.11 Rabl2
 RAB, member RAS oncogene family-like 2
 16061
 0.15
chr4_46413029_46413416 0.11 Hemgn
 hemogen
 284
 0.86
chr7_3666562_3667626 0.11 Tmc4
 transmembrane channel-like gene family 4
 211
 0.74
chr6_124832302_124832570 0.11 Cdca3
 cell division cycle associated 3
 2061
 0.12
chr12_30905934_30906220 0.11 Acp1
 acid phosphatase 1, soluble
 5472
 0.19
chr7_24368915_24369193 0.11 Kcnn4
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
 1209
 0.26
chr10_60078294_60078579 0.10 Spock2
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
 27783
 0.16
chr18_34783686_34784162 0.10 Kdm3b
 KDM3B lysine (K)-specific demethylase 3B
 6819
 0.13
chr11_101449130_101449504 0.10 Ifi35
 interferon-induced protein 35
 747
 0.35
chr6_131384992_131385187 0.10 Ybx3
 Y box protein 3
 3349
 0.18
chr7_99822281_99822623 0.10 Neu3
 neuraminidase 3
 5965
 0.13
chr11_76088787_76088938 0.10 Vps53
 VPS53 GARP complex subunit
 3817
 0.23
chr11_69588843_69589373 0.10 Trp53
 transformation related protein 53
 413
 0.61
chr3_96223834_96224156 0.10 H2bc21
 H2B clustered histone 21
 2876
 0.05
chr4_134019273_134020476 0.10 Lin28a
 lin-28 homolog A (C. elegans)
 1033
 0.34
chr17_27559013_27559762 0.10 Hmga1
 high mobility group AT-hook 1
 2692
 0.11
chr3_35923525_35923989 0.10 Dcun1d1
 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
 2569
 0.18
chr8_122378366_122378701 0.10 Zc3h18
 zinc finger CCCH-type containing 18
 1852
 0.2
chr9_63604142_63604361 0.10 Aagab
 alpha- and gamma-adaptin binding protein
 1591
 0.32
chr16_58678686_58678993 0.10 Cpox
 coproporphyrinogen oxidase
 983
 0.44
chr15_66809584_66809797 0.10 Sla
 src-like adaptor
 2903
 0.26
chr11_97780583_97780734 0.10 Gm27326
 predicted gene, 27326
 382
 0.6

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of Figla

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0072050 S-shaped body morphogenesis(GO:0072050)
0.0 0.2 GO:0086045 membrane depolarization during AV node cell action potential(GO:0086045)
0.0 0.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0 0.1 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.0 0.1 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.0 0.1 GO:0009092 homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.0 0.2 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.1 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:0035977 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.1 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0014858 positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0 0.0 GO:2000828 regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.1 GO:0048069 eye pigmentation(GO:0048069)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.0 0.1 GO:1900451 positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.0 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.0 GO:0015888 thiamine transport(GO:0015888)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.1 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.0 0.0 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0 0.0 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0 0.0 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) late nucleophagy(GO:0044805)
0.0 0.1 GO:0000059 protein import into nucleus, docking(GO:0000059)
0.0 0.0 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0051657 maintenance of organelle location(GO:0051657)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.1 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0 0.1 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.0 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.1 GO:0097413 Lewy body(GO:0097413)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0 0.0 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.0 0.3 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.0 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0043842 Kdo transferase activity(GO:0043842)
0.0 0.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.0 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.0 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.0 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.1 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.0 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis