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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Foxg1

Z-value: 0.67

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Transcription factors associated with Foxg1

Gene Symbol	Gene ID	Gene Info
Foxg1 Ensembl NCBI MGI UniProt	ENSMUSG00000020950.9	Foxg1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Foxg1	chr12_49382714_49384085	392	0.722333	-0.02	8.9e-01	Click!

Activity of the Foxg1 motif across conditions

Conditions sorted by the z-value of the Foxg1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_57784547_57786586	2.14	Fabp7	fatty acid binding protein 7, brain	643	0.68
chr16_18429039_18430122	1.61	Txnrd2	thioredoxin reductase 2	655	0.54
chr8_80494890_80495139	1.35	Gypa	glycophorin A	1233	0.53
chr7_78914724_78915335	1.33	Isg20	interferon-stimulated protein	700	0.57
chr8_80497324_80498362	1.31	Gypa	glycophorin A	4062	0.27
chr6_118757029_118757180	1.29	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	870	0.71
chr7_62422629_62423664	1.25	Gm32061	predicted gene, 32061	99	0.96
chr1_168287219_168287370	1.04	Gm37524	predicted gene, 37524	50377	0.16
chr11_102364387_102365146	1.03	Slc4a1	solute carrier family 4 (anion exchanger), member 1	481	0.67
chr11_54026747_54027441	0.96	Slc22a4	solute carrier family 22 (organic cation transporter), member 4	858	0.54
chr2_105680581_105683424	0.94	Pax6	paired box 6	290	0.89
chr7_143004834_143005031	0.87	Tspan32	tetraspanin 32	114	0.94
chr8_80868370_80868642	0.87	Gm31105	predicted gene, 31105	11434	0.18
chr13_41236642_41237224	0.84	Gm32063	predicted gene, 32063	588	0.6
chr7_90083908_90084239	0.79	Gm5341	predicted pseudogene 5341	23895	0.11
chr6_87776091_87777171	0.78	Gm43904	predicted gene, 43904	488	0.55
chr9_91378153_91379783	0.76	Zic4	zinc finger protein of the cerebellum 4	326	0.81
chr6_128526086_128526400	0.72	Pzp	PZP, alpha-2-macroglobulin like	460	0.65
chr17_24202438_24203465	0.71	Tbc1d24	TBC1 domain family, member 24	2531	0.12
chr6_52162888_52164000	0.70	Hoxa2	homeobox A2	1387	0.15
chr2_74713881_74716227	0.69	Hoxd3os1	homeobox D3, opposite strand 1	942	0.23
chr10_12962620_12962953	0.68	Stx11	syntaxin 11	1472	0.41
chr10_91967800_91968283	0.67	Gm31592	predicted gene, 31592	79212	0.1
chr11_74572004_74572226	0.66	Rap1gap2	RAP1 GTPase activating protein 2	18009	0.18
chr12_116407284_116407647	0.66	Ncapg2	non-SMC condensin II complex, subunit G2	2031	0.24
chr9_70934045_70934653	0.65	Lipc	lipase, hepatic	264	0.92
chr4_119183706_119183857	0.65	Ermap	erythroblast membrane-associated protein	4966	0.1
chr17_71525336_71525487	0.64	Ndc80	NDC80 kinetochore complex component	1379	0.24
chr4_141076285_141076997	0.64	Necap2	NECAP endocytosis associated 2	1584	0.24
chr13_47104855_47106138	0.63	Dek	DEK oncogene (DNA binding)	334	0.73
chr4_143045346_143045497	0.62	6330411D24Rik	RIKEN cDNA 6330411D24 gene	28345	0.19
chr10_80570596_80572042	0.61	Klf16	Kruppel-like factor 16	6002	0.08
chr5_116021804_116022431	0.61	Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	471	0.73
chr14_109511936_109512087	0.60	Gm18977	predicted gene, 18977	11088	0.28
chr18_63727695_63728070	0.59	Wdr7	WD repeat domain 7	11182	0.16
chr3_85991395_85991798	0.59	Prss48	protease, serine 48	10895	0.12
chr11_97471430_97471581	0.58	Arhgap23	Rho GTPase activating protein 23	19375	0.13
chr9_107301461_107301858	0.58	Gm17041	predicted gene 17041	179	0.88
chr2_26349516_26349790	0.57	Dnlz	DNL-type zinc finger	2447	0.12
chr4_129463918_129464422	0.57	Bsdc1	BSD domain containing 1	372	0.74
chr15_77756117_77756516	0.56	Apol8	apolipoprotein L 8	666	0.54
chr12_24645782_24646298	0.55	Klf11	Kruppel-like factor 11	5234	0.16
chr10_80569864_80570541	0.55	Klf16	Kruppel-like factor 16	7119	0.08
chr6_54851742_54852146	0.54	Znrf2	zinc and ring finger 2	34496	0.15
chr16_20713558_20714737	0.54	Clcn2	chloride channel, voltage-sensitive 2	479	0.59
chr19_36896833_36896984	0.53	Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	16335	0.17
chr4_119189472_119189950	0.53	Ermap	erythroblast membrane-associated protein	240	0.84
chr5_116573497_116573648	0.53	Gm42854	predicted gene 42854	77	0.97
chr7_45238275_45239242	0.53	Cd37	CD37 antigen	38	0.92
chr7_99803412_99803631	0.53	F730035P03Rik	RIKEN cDNA F730035P03 gene	21982	0.1
chr9_43746633_43747189	0.52	Gm30015	predicted gene, 30015	811	0.54
chr11_27966865_27967016	0.52	Gm12080	predicted gene 12080	79095	0.11
chr4_130006445_130007362	0.51	Adgrb2	adhesion G protein-coupled receptor B2	2973	0.19
chr12_69783268_69783598	0.51	4930512B01Rik	RIKEN cDNA 4930512B01 gene	6855	0.13
chr14_25536740_25537143	0.51	Mir3075	microRNA 3075	2502	0.26
chr16_8687825_8687976	0.51	Gm5767	predicted gene 5767	5070	0.14
chr14_69282071_69282727	0.51	Gm20236	predicted gene, 20236	259	0.8
chr14_69500320_69500976	0.50	Gm37094	predicted gene, 37094	258	0.81
chr5_74064229_74066220	0.50	Usp46	ubiquitin specific peptidase 46	524	0.65
chr15_73182349_73182927	0.49	Ago2	argonaute RISC catalytic subunit 2	2297	0.3
chr12_118650955_118651106	0.49	Gm9267	predicted gene 9267	48353	0.15
chr11_4487067_4487818	0.49	Mtmr3	myotubularin related protein 3	924	0.59
chr3_95517184_95517335	0.48	Ctss	cathepsin S	9527	0.1
chr14_118229781_118230155	0.48	Gm4675	predicted gene 4675	6264	0.13
chr10_19483385_19484135	0.48	Gm33104	predicted gene, 33104	2955	0.29
chr11_69399334_69402458	0.48	Kdm6bos	KDM1 lysine (K)-specific demethylase 6B, opposite strand	617	0.47
chr6_89355649_89355800	0.47	Plxna1	plexin A1	1993	0.29
chr10_78427526_78427677	0.47	4921516A02Rik	RIKEN cDNA 4921516A02 gene	670	0.41
chr10_81153659_81153953	0.46	Pias4	protein inhibitor of activated STAT 4	2318	0.11
chr17_15501788_15502060	0.46	Tbp	TATA box binding protein	1065	0.34
chr3_154092419_154093223	0.46	Gm3076	predicted gene 3076	39519	0.13
chr5_137290070_137291279	0.46	Ache	acetylcholinesterase	1427	0.17
chr16_8670580_8670942	0.45	Carhsp1	calcium regulated heat stable protein 1	1394	0.29
chr13_75715151_75715379	0.45	Ell2	elongation factor RNA polymerase II 2	7554	0.13
chr13_23417840_23417991	0.45	Abt1	activator of basal transcription 1	5951	0.09
chr18_54422355_54422833	0.44	Redrum	Redrum, erythroid developmental long intergenic non-protein coding transcript	299	0.93
chr13_100676259_100676561	0.44	Ccdc125	coiled-coil domain containing 125	6637	0.12
chr14_115046048_115046375	0.44	Mir92-1	microRNA 92-1	1784	0.14
chr5_139391800_139391951	0.43	Gpr146	G protein-coupled receptor 146	2090	0.2
chr11_94264019_94264170	0.43	Gm21885	predicted gene, 21885	17779	0.14
chr15_103250315_103251530	0.43	Nfe2	nuclear factor, erythroid derived 2	543	0.62
chr7_62414907_62415687	0.42	Mkrn3	makorin, ring finger protein, 3	4842	0.18
chr1_90947541_90947692	0.42	Prlh	prolactin releasing hormone	5492	0.15
chr10_127323007_127323393	0.42	Arhgap9	Rho GTPase activating protein 9	507	0.55
chr11_4488078_4488309	0.42	Mtmr3	myotubularin related protein 3	173	0.95
chr2_116056837_116059755	0.41	Meis2	Meis homeobox 2	546	0.75
chr7_16103274_16103425	0.41	Napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	4267	0.14
chr11_116647941_116648526	0.41	Prcd	photoreceptor disc component	5301	0.09
chr1_9780296_9780452	0.41	1700034P13Rik	RIKEN cDNA 1700034P13 gene	3404	0.17
chr16_91222072_91224159	0.41	Gm49614	predicted gene, 49614	189	0.9
chr4_108060098_108060443	0.40	Scp2	sterol carrier protein 2, liver	11093	0.13
chrX_42155222_42155373	0.40	Stag2	stromal antigen 2	3117	0.24
chr10_57499477_57499901	0.40	Hsf2	heat shock factor 2	685	0.68
chr5_137382579_137382730	0.40	Zan	zonadhesin	19084	0.09
chr6_90333325_90334527	0.40	Uroc1	urocanase domain containing 1	637	0.57
chr17_34950362_34951201	0.40	Snord52	small nucleolar RNA, C/D box 52	236	0.58
chr4_154966258_154966899	0.39	Pank4	pantothenate kinase 4	2445	0.18
chr16_8612946_8613812	0.39	Abat	4-aminobutyrate aminotransferase	501	0.67
chr3_89209863_89210054	0.39	Mtx1	metaxin 1	136	0.74
chr11_48803049_48803584	0.39	Rack1	receptor for activated C kinase 1	164	0.48
chr6_88501831_88502191	0.39	Gm44170	predicted gene, 44170	1594	0.29
chr8_71377836_71378740	0.39	Nr2f6	nuclear receptor subfamily 2, group F, member 6	2498	0.14
chr12_103735553_103735704	0.39	Serpina1b	serine (or cysteine) preptidase inhibitor, clade A, member 1B	2530	0.16
chr6_41702817_41703169	0.39	Kel	Kell blood group	1346	0.32
chr18_14459496_14459647	0.39	Gm50098	predicted gene, 50098	32434	0.17
chr1_67125661_67125812	0.39	Cps1	carbamoyl-phosphate synthetase 1	2710	0.34
chr7_127661632_127661895	0.38	Gm44760	predicted gene 44760	3529	0.11
chr13_73483496_73483773	0.38	Lpcat1	lysophosphatidylcholine acyltransferase 1	11883	0.21
chr2_152785455_152786223	0.38	Gm23802	predicted gene, 23802	12950	0.11
chr7_19691393_19692666	0.38	Apoc1	apolipoprotein C-I	462	0.59
chr1_136960004_136960405	0.38	Nr5a2	nuclear receptor subfamily 5, group A, member 2	176	0.96
chr19_14889594_14889745	0.38	Gm5513	predicted pseudogene 5513	71097	0.13
chr11_96202439_96204563	0.38	Hoxb13	homeobox B13	9185	0.1
chrX_150554562_150554911	0.37	Alas2	aminolevulinic acid synthase 2, erythroid	699	0.62
chrX_96241467_96241787	0.37	Mir223	microRNA 223	1190	0.35
chr15_12203564_12203715	0.37	Mtmr12	myotubularin related protein 12	1389	0.28
chr5_35609246_35609861	0.37	Acox3	acyl-Coenzyme A oxidase 3, pristanoyl	546	0.71
chr9_79823449_79823600	0.36	Filip1	filamin A interacting protein 1	7474	0.15
chr1_168381191_168381418	0.36	Gm38381	predicted gene, 38381	30496	0.18
chr13_59668566_59668950	0.36	Golm1	golgi membrane protein 1	7014	0.1
chr14_98164357_98165375	0.36	Dach1	dachshund family transcription factor 1	4677	0.28
chr9_70502649_70503336	0.36	Rnf111	ring finger 111	362	0.81
chr4_154960570_154962200	0.36	Gm20421	predicted gene 20421	293	0.57
chr12_29529828_29531185	0.36	Gm20208	predicted gene, 20208	609	0.74
chr1_121177384_121178460	0.36	Gm29359	predicted gene 29359	46354	0.15
chr11_58868459_58868610	0.35	2810021J22Rik	RIKEN cDNA 2810021J22 gene	1267	0.21
chr8_70656342_70656817	0.35	Pgpep1	pyroglutamyl-peptidase I	859	0.37
chr2_84735706_84738103	0.35	Ypel4	yippee like 4	2677	0.11
chr14_61650328_61650516	0.35	Gm27017	predicted gene, 27017	1472	0.19
chr16_17949655_17949806	0.35	Slc25a1	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	21511	0.09
chr8_61515132_61515409	0.35	Palld	palladin, cytoskeletal associated protein	630	0.77
chr15_96292843_96292994	0.34	Arid2	AT rich interactive domain 2 (ARID, RFX-like)	5345	0.21
chr11_3488055_3488462	0.34	Pla2g3	phospholipase A2, group III	26	0.95
chr1_71100990_71101619	0.34	Bard1	BRCA1 associated RING domain 1	1842	0.43
chr15_76179745_76180476	0.34	Plec	plectin	7933	0.09
chr11_60538080_60539333	0.34	Alkbh5	alkB homolog 5, RNA demethylase	728	0.48
chr8_47531539_47531690	0.34	Trappc11	trafficking protein particle complex 11	1853	0.25
chr4_130108875_130109149	0.34	Pef1	penta-EF hand domain containing 1	1456	0.34
chr5_64588253_64588408	0.34	Gm3716	predicted gene 3716	14830	0.11
chr9_114562215_114562607	0.34	Trim71	tripartite motif-containing 71	1958	0.3
chr2_33867715_33867866	0.34	Mvb12b	multivesicular body subunit 12B	19055	0.2
chr3_108573576_108574011	0.33	Taf13	TATA-box binding protein associated factor 13	2082	0.15
chr13_97778790_97779019	0.33	Gm47577	predicted gene, 47577	11660	0.15
chr9_110653127_110654518	0.33	Nbeal2	neurobeachin-like 2	320	0.77
chr13_83741336_83742027	0.33	C130071C03Rik	RIKEN cDNA C130071C03 gene	2818	0.16
chr10_80834399_80836114	0.33	Mir1982	microRNA 1982	6459	0.07
chr10_43580494_43581222	0.33	Cd24a	CD24a antigen	923	0.48
chr11_55449682_55449833	0.33	Atox1	antioxidant 1 copper chaperone	11440	0.11
chr1_75235806_75235957	0.33	Dnajb2	DnaJ heat shock protein family (Hsp40) member B2	525	0.5
chr18_54436033_54436373	0.32	Redrum	Redrum, erythroid developmental long intergenic non-protein coding transcript	13908	0.23
chr5_34369874_34370083	0.32	Fam193a	family with sequence homology 193, member A	45	0.97
chr17_26974792_26975099	0.32	Zbtb9	zinc finger and BTB domain containing 9	1728	0.14
chr1_130732649_130733832	0.32	AA986860	expressed sequence AA986860	1130	0.29
chr16_8687033_8687675	0.32	Gm5767	predicted gene 5767	4524	0.14
chr10_81349455_81350420	0.32	Hmg20b	high mobility group 20B	254	0.74
chr13_59763390_59763779	0.32	Isca1	iron-sulfur cluster assembly 1	17	0.94
chr1_23282787_23283466	0.31	Gm27028	predicted gene, 27028	8411	0.12
chr19_53332272_53332423	0.31	Mxi1	MAX interactor 1, dimerization protein	1939	0.25
chr2_105908509_105908660	0.31	Immp1l	IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)	3946	0.21
chr9_59660933_59662180	0.31	Pkm	pyruvate kinase, muscle	3246	0.17
chr4_100995628_100995943	0.31	Cachd1	cache domain containing 1	1075	0.53
chrX_153501207_153502250	0.31	Ubqln2	ubiquilin 2	3501	0.22
chr5_112001842_112002220	0.31	Gm42488	predicted gene 42488	57796	0.13
chr11_95013727_95013935	0.30	Samd14	sterile alpha motif domain containing 14	3550	0.13
chr5_104043873_104044030	0.30	Nudt9	nudix (nucleoside diphosphate linked moiety X)-type motif 9	2355	0.16
chr1_177150233_177151142	0.30	Gm38146	predicted gene, 38146	15234	0.16
chr5_142589584_142589802	0.30	Mmd2	monocyte to macrophage differentiation-associated 2	6825	0.15
chr9_107723003_107723309	0.30	Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	12681	0.09
chr1_139375797_139376462	0.30	Crb1	crumbs family member 1, photoreceptor morphogenesis associated	912	0.52
chr3_84219260_84219630	0.30	Trim2	tripartite motif-containing 2	1400	0.49
chr3_27146047_27146198	0.30	Ect2	ect2 oncogene	1079	0.48
chr2_147180654_147181518	0.30	Nkx2-2os	NK2 homeobox 2, opposite strand	2997	0.2
chr3_105054815_105055585	0.29	Cttnbp2nl	CTTNBP2 N-terminal like	2054	0.3
chr11_57791079_57791485	0.29	2010001A14Rik	RIKEN cDNA 2010001A14 gene	10116	0.14
chr16_30129996_30130199	0.29	Gm6029	predicted gene 6029	9362	0.15
chr10_50891809_50893729	0.29	Sim1	single-minded family bHLH transcription factor 1	1985	0.43
chrX_12067726_12070081	0.29	Bcor	BCL6 interacting corepressor	11650	0.26
chr7_100492685_100494805	0.29	Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	50	0.95
chr4_132274460_132275262	0.29	Taf12	TATA-box binding protein associated factor 12	445	0.57
chr4_140704067_140704218	0.29	Rcc2	regulator of chromosome condensation 2	2669	0.17
chr8_26384770_26384921	0.29	Gm31898	predicted gene, 31898	50868	0.1
chr16_96441846_96442164	0.29	Itgb2l	integrin beta 2-like	1607	0.32
chr11_102023682_102023894	0.29	Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	2069	0.17
chr1_161734865_161735433	0.28	Gm15429	predicted pseudogene 15429	7660	0.15
chr8_92364963_92367136	0.28	Irx5	Iroquois homeobox 5	8300	0.18
chr14_34373709_34374792	0.28	Sncg	synuclein, gamma	539	0.58
chr15_76666348_76670076	0.28	Foxh1	forkhead box H1	1590	0.15
chr5_117122436_117122623	0.28	Taok3	TAO kinase 3	2400	0.21
chr6_31124166_31124436	0.28	5330406M23Rik	RIKEN cDNA 5330406M23 gene	13381	0.11
chr1_13574325_13574563	0.28	Tram1	translocating chain-associating membrane protein 1	5354	0.24
chr6_122609501_122610041	0.28	Gdf3	growth differentiation factor 3	53	0.95
chr11_106312219_106312370	0.28	Cd79b	CD79B antigen	2235	0.17
chr11_100627464_100627615	0.28	Nkiras2	NFKB inhibitor interacting Ras-like protein 2	4528	0.11
chr12_91747422_91747591	0.27	Ston2	stonin 2	1422	0.4
chr11_45855533_45856802	0.27	Clint1	clathrin interactor 1	4203	0.18
chr19_55285309_55285619	0.27	Acsl5	acyl-CoA synthetase long-chain family member 5	1130	0.48
chr14_30942231_30942467	0.27	Itih1	inter-alpha trypsin inhibitor, heavy chain 1	928	0.4
chr15_98843609_98844032	0.27	Kmt2d	lysine (K)-specific methyltransferase 2D	5417	0.09
chr3_68695313_68695505	0.27	Il12a	interleukin 12a	1388	0.42
chr4_53633406_53634189	0.27	Fsd1l	fibronectin type III and SPRY domain containing 1-like	2081	0.3

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxg1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.3	0.9	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.2	0.8	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.2	1.2	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.2	0.5	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1	0.6	GO:0015879	carnitine transport(GO:0015879)
0.1	0.6	GO:0034382	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.1	1.6	GO:0060134	prepulse inhibition(GO:0060134)
0.1	0.3	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1	0.4	GO:0061113	pancreas morphogenesis(GO:0061113)
0.1	0.3	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1	0.3	GO:0070889	platelet alpha granule organization(GO:0070889)
0.1	0.2	GO:0045583	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1	0.1	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.1	0.3	GO:2000981	negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.1	0.2	GO:0001555	oocyte growth(GO:0001555)
0.1	0.3	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1	0.3	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.1	0.3	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1	0.2	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
0.1	0.1	GO:0014901	regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.1	0.3	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.1	0.2	GO:0035553	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1	0.2	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.1	0.2	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.1	0.2	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.1	0.2	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.1	0.1	GO:1990169	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1	0.2	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.1	0.3	GO:0048859	formation of anatomical boundary(GO:0048859)
0.1	0.3	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.0	GO:0010535	positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0	0.3	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0	1.1	GO:0000305	response to oxygen radical(GO:0000305)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.2	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.3	GO:0043320	natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0033234	negative regulation of protein sumoylation(GO:0033234)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.7	GO:0046685	response to arsenic-containing substance(GO:0046685)
0.0	0.1	GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.2	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.3	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.2	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.7	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.1	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.2	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.3	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.2	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0	0.2	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.3	GO:0002329	pre-B cell differentiation(GO:0002329)
0.0	0.2	GO:0071864	positive regulation of cell proliferation in bone marrow(GO:0071864)
0.0	0.2	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0	0.4	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.7	GO:0006308	DNA catabolic process(GO:0006308)
0.0	0.1	GO:0021538	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0	0.2	GO:0061304	retinal blood vessel morphogenesis(GO:0061304)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0	0.1	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.0	0.1	GO:0021569	rhombomere 3 development(GO:0021569)
0.0	0.1	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.0	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.3	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.2	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0071673	positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.0	0.0	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0060339	negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0	0.1	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0	0.2	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.0	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0	0.1	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0	0.1	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0	0.1	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.0	0.0	GO:1901873	regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0	0.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601)
0.0	0.1	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.1	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0	0.1	GO:0032380	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.0	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:1902369	negative regulation of RNA catabolic process(GO:1902369)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.0	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	0.0	GO:0060847	endothelial cell fate specification(GO:0060847)
0.0	0.2	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.0	0.1	GO:0009181	purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.0	0.1	GO:0070922	small RNA loading onto RISC(GO:0070922)
0.0	0.1	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.0	0.1	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.1	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0034393	positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.0	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.1	GO:0014043	negative regulation of neuron maturation(GO:0014043)
0.0	0.1	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.0	GO:1904220	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.0	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0	0.3	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.1	GO:1903961	positive regulation of anion transmembrane transport(GO:1903961)
0.0	0.1	GO:0006370	7-methylguanosine mRNA capping(GO:0006370)
0.0	0.0	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.0	0.1	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.0	GO:0016539	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0	0.0	GO:0036484	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.0	0.0	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.0	GO:1903275	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.3	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.0	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.0	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.0	0.0	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:2000523	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.0	0.2	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.0	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.1	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0	0.0	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.0	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0071684	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.0	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.0	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.0	0.0	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.0	GO:1905154	negative regulation of membrane invagination(GO:1905154)
0.0	0.1	GO:0045144	meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
0.0	0.0	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:0033210	leptin-mediated signaling pathway(GO:0033210)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.2	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.2	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:0051938	L-glutamate import(GO:0051938)
0.0	0.0	GO:0032201	telomere maintenance via semi-conservative replication(GO:0032201) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.0	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.0	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.1	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.1	GO:1904355	positive regulation of telomere capping(GO:1904355)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0097503	sialylation(GO:0097503)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.1	GO:2000637	positive regulation of gene silencing by miRNA(GO:2000637)
0.0	0.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.1	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
0.0	0.0	GO:0033686	positive regulation of luteinizing hormone secretion(GO:0033686)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.0	0.0	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	0.2	GO:0043293	apoptosome(GO:0043293)
0.1	0.2	GO:0000125	PCAF complex(GO:0000125)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.2	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.5	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.2	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.2	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.2	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.2	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.2	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.0	0.2	GO:0034361	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.2	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.6	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.8	GO:0008305	integrin complex(GO:0008305)
0.0	0.9	GO:0015030	Cajal body(GO:0015030)
0.0	0.1	GO:0031417	NatC complex(GO:0031417)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.0	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.1	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.0	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.5	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.3	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.1	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.1	GO:0032584	growth cone membrane(GO:0032584)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0070876	SOSS complex(GO:0070876)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.0	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.0	GO:0033596	TSC1-TSC2 complex(GO:0033596)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.0	GO:0000811	GINS complex(GO:0000811)
0.0	0.1	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.0	0.0	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:0034709	methylosome(GO:0034709)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	1.1	GO:0072562	blood microparticle(GO:0072562)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3	0.8	GO:0030620	U2 snRNA binding(GO:0030620)
0.2	0.9	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.1	0.6	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1	0.6	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1	0.8	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.5	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.1	0.7	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1	0.2	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	0.2	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.1	0.8	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.1	0.2	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.1	0.2	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	0.2	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.0	0.2	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.3	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	1.6	GO:0005504	fatty acid binding(GO:0005504)
0.0	0.2	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.2	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.5	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.2	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.1	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.3	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.3	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.0	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.2	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.2	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.3	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.3	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0018593	mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0	0.1	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0	0.3	GO:0016594	glycine binding(GO:0016594)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.1	GO:0016868	intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.0	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.3	GO:0008483	transaminase activity(GO:0008483)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.0	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0004096	catalase activity(GO:0004096)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.0	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.0	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.0	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0070628	proteasome binding(GO:0070628)
0.0	0.0	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.1	GO:0008932	lytic endotransglycosylase activity(GO:0008932)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0001094	TFIID-class transcription factor binding(GO:0001094)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	PID MYC PATHWAY	C-MYC pathway
0.7	PID LKB1 PATHWAY	LKB1 signaling events
0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.9	PID CDC42 PATHWAY	CDC42 signaling events
0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.4	PID PLK1 PATHWAY	PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	0.6	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.6	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.6	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.4	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.2	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.7	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.3	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.6	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.4	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.0	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.1	REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.0	0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.2	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.5	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.2	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.2	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation