Project

ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Foxo3

Z-value: 0.55

Motif logo

Transcription factors associated with Foxo3

Gene Symbol	Gene ID	Gene Info
Foxo3 Ensembl NCBI MGI UniProt	ENSMUSG00000048756.5	Foxo3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Foxo3	chr10_42272287_42272486	4310	0.288598	-0.39	2.1e-03	Click!
Foxo3	chr10_42244059_42244384	14145	0.250140	-0.31	1.6e-02	Click!
Foxo3	chr10_42251868_42252252	6306	0.275620	-0.31	1.6e-02	Click!
Foxo3	chr10_42247495_42248433	10402	0.259004	-0.30	1.9e-02	Click!
Foxo3	chr10_42262321_42262472	4030	0.300609	-0.30	1.9e-02	Click!

Activity of the Foxo3 motif across conditions

Conditions sorted by the z-value of the Foxo3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_150261018_150262108	0.78	Fry	FRY microtubule binding protein	1796	0.34
chr5_150260534_150260992	0.71	Fry	FRY microtubule binding protein	996	0.55
chr8_25521556_25521707	0.60	Fgfr1	fibroblast growth factor receptor 1	1794	0.24
chr18_69521278_69522871	0.60	Tcf4	transcription factor 4	73	0.98
chr8_23669376_23670424	0.54	Zmat4	zinc finger, matrin type 4	226	0.95
chr5_3432895_3433605	0.53	Cdk6	cyclin-dependent kinase 6	37699	0.12
chr8_84765171_84766430	0.52	Nfix	nuclear factor I/X	7596	0.11
chr6_55617797_55618517	0.51	Neurod6	neurogenic differentiation 6	63106	0.11
chr6_8352545_8353207	0.49	Gm16055	predicted gene 16055	11260	0.18
chr2_4300456_4301144	0.49	Frmd4a	FERM domain containing 4A	85	0.78
chr5_57728215_57728366	0.49	Gm42635	predicted gene 42635	3897	0.15
chr7_12421647_12422940	0.47	Zfp551	zinc fingr protein 551	146	0.92
chr18_49543238_49543945	0.46	1700044K03Rik	RIKEN cDNA 1700044K03 gene	20302	0.23
chr13_4662525_4663068	0.46	Gm40658	predicted gene, 40658	18889	0.18
chr3_82141940_82142375	0.44	Gucy1a1	guanylate cyclase 1, soluble, alpha 1	2916	0.3
chr6_136167149_136168437	0.42	Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	4096	0.25
chr7_144132849_144134003	0.42	Gm44999	predicted gene 44999	22341	0.2
chr2_27539183_27539675	0.41	Gm25541	predicted gene, 25541	501	0.63
chr7_30291688_30292446	0.41	Clip3	CAP-GLY domain containing linker protein 3	109	0.9
chr11_109649280_109649701	0.41	Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	85	0.97
chr5_57721137_57722906	0.40	Pcdh7	protocadherin 7	108	0.94
chr3_63296309_63296634	0.39	Mme	membrane metallo endopeptidase	376	0.91
chr2_20339506_20340619	0.38	Etl4	enhancer trap locus 4	238	0.94
chr1_153328595_153328920	0.38	Lamc1	laminin, gamma 1	4029	0.2
chr5_107167246_107168359	0.38	Gm43423	predicted gene 43423	7231	0.17
chr9_10903843_10905236	0.38	Cntn5	contactin 5	90	0.65
chr11_93818459_93818772	0.36	Utp18	UTP18 small subunit processome component	57528	0.12
chr18_69125035_69125283	0.36	Gm23536	predicted gene, 23536	48961	0.13
chr13_44946033_44946635	0.36	Dtnbp1	dystrobrevin binding protein 1	810	0.7
chr1_23490694_23490976	0.36	Gm7784	predicted gene 7784	11296	0.24
chr14_50896223_50897440	0.35	Klhl33	kelch-like 33	625	0.49
chr18_69349496_69350227	0.35	Tcf4	transcription factor 4	917	0.69
chr2_134787876_134788027	0.35	Plcb1	phospholipase C, beta 1	1421	0.42
chr16_50380747_50382000	0.35	Bbx	bobby sox HMG box containing	48539	0.18
chr13_93307758_93308718	0.34	Homer1	homer scaffolding protein 1	204	0.92
chr9_81629834_81629994	0.34	D430036J16Rik	RIKEN cDNA D430036J16 gene	1637	0.38
chr19_32866529_32866680	0.34	Pten	phosphatase and tensin homolog	55379	0.14
chr8_109250884_109251908	0.33	D030068K23Rik	RIKEN cDNA D030068K23 gene	1530	0.52
chr17_70521708_70522843	0.33	Dlgap1	DLG associated protein 1	113	0.98
chr2_120244697_120245562	0.33	Pla2g4e	phospholipase A2, group IVE	21	0.89
chr2_167233751_167233909	0.33	Ptgis	prostaglandin I2 (prostacyclin) synthase	6759	0.15
chr8_45109829_45110486	0.33	Gm30504	predicted gene, 30504	324	0.88
chr7_87584791_87585125	0.32	Grm5	glutamate receptor, metabotropic 5	560	0.85
chr2_92198196_92198596	0.31	Mir1955	microRNA 1955	6419	0.17
chr11_63412437_63413498	0.31	B130011K05Rik	RIKEN cDNA B130011K05 gene	202	0.96
chr7_91092040_91092191	0.31	Dlg2	discs large MAGUK scaffold protein 2	1387	0.4
chr7_109783136_109783287	0.30	Nrip3	nuclear receptor interacting protein 3	1186	0.34
chr16_42782105_42782459	0.30	4932412D23Rik	RIKEN cDNA 4932412D23 gene	93305	0.08
chr13_28416755_28419194	0.30	Gm40841	predicted gene, 40841	1889	0.42
chr15_74679054_74679804	0.30	Arc	activity regulated cytoskeletal-associated protein	6859	0.1
chr19_16061967_16062187	0.29	Rpl37-ps1	ribosomal protein 37, pseudogene 1	36626	0.15
chr2_74699510_74699661	0.29	Gm44463	predicted gene, 44463	1557	0.11
chr4_25798002_25798171	0.29	Fut9	fucosyltransferase 9	1769	0.36
chr4_153110438_153110637	0.29	Gm13173	predicted gene 13173	36406	0.21
chr1_35849717_35849997	0.29	1110002O04Rik	RIKEN cDNA 1110002O04 gene	29988	0.16
chr2_96319240_96319943	0.29	Lrrc4c	leucine rich repeat containing 4C	1375	0.61
chr4_137043562_137044547	0.29	Zbtb40	zinc finger and BTB domain containing 40	4641	0.19
chr3_34773718_34774341	0.28	Gm38509	predicted gene, 38509	1954	0.34
chrX_51678321_51678764	0.28	Hs6st2	heparan sulfate 6-O-sulfotransferase 2	2023	0.41
chr2_59438036_59438472	0.28	Gm13549	predicted gene 13549	38473	0.13
chr12_54702794_54702945	0.28	Rpl31-ps17	ribosomal protein L31, pseudogene 17	1163	0.21
chr16_10447447_10447926	0.28	Tvp23a	trans-golgi network vesicle protein 23A	324	0.87
chr15_85674019_85674170	0.28	Lncppara	long noncoding RNA near Ppara	20478	0.13
chr2_64172800_64172951	0.28	Fign	fidgetin	74837	0.13
chr18_54988564_54988904	0.27	Zfp608	zinc finger protein 608	1432	0.35
chr13_46420548_46420948	0.27	Rbm24	RNA binding motif protein 24	197	0.96
chr5_14515030_14515887	0.27	Pclo	piccolo (presynaptic cytomatrix protein)	465	0.81
chr14_57132708_57133925	0.27	Gjb6	gap junction protein, beta 6	35	0.97
chr2_145862226_145862910	0.27	Rin2	Ras and Rab interactor 2	76	0.97
chr18_38928285_38929463	0.27	Fgf1	fibroblast growth factor 1	283	0.92
chr3_100804632_100805148	0.26	Vtcn1	V-set domain containing T cell activation inhibitor 1	20569	0.2
chr1_38987342_38987601	0.26	Pdcl3	phosducin-like 3	370	0.84
chr17_17448568_17449744	0.26	Lix1	limb and CNS expressed 1	336	0.88
chr1_185193564_185193767	0.26	Rab3gap2	RAB3 GTPase activating protein subunit 2	10452	0.15
chr10_85389057_85389718	0.26	Btbd11	BTB (POZ) domain containing 11	2560	0.31
chr5_146921086_146921291	0.26	Gtf3a	general transcription factor III A	27469	0.14
chr8_109185308_109186079	0.25	D030068K23Rik	RIKEN cDNA D030068K23 gene	64173	0.13
chr2_167239298_167240893	0.25	Ptgis	prostaglandin I2 (prostacyclin) synthase	494	0.75
chr2_180388160_180389480	0.25	Mir1a-1	microRNA 1a-1	228	0.89
chr11_42181406_42181557	0.25	Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	623	0.84
chr4_123406736_123407057	0.25	Macf1	microtubule-actin crosslinking factor 1	5332	0.18
chr4_14621039_14622190	0.25	Slc26a7	solute carrier family 26, member 7	55	0.99
chr6_53817061_53817543	0.25	Gm16499	predicted gene 16499	1441	0.39
chr9_52680840_52680991	0.25	Gm1715	predicted gene 1715	1052	0.41
chr10_111100028_111100179	0.25	Gm48851	predicted gene, 48851	2768	0.22
chr2_65846012_65846807	0.25	Csrnp3	cysteine-serine-rich nuclear protein 3	554	0.79
chr14_86261599_86262221	0.25	4930529K09Rik	RIKEN cDNA 4930529K09 gene	15907	0.12
chrX_7821779_7823061	0.25	Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	113	0.92
chr7_78569130_78569412	0.25	Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	2620	0.26
chr17_8388660_8390136	0.25	Gm5491	predicted gene 5491	4738	0.15
chr19_37907678_37907926	0.24	Myof	myoferlin	1978	0.37
chr17_67303669_67304273	0.24	Ptprm	protein tyrosine phosphatase, receptor type, M	50102	0.18
chr16_89957880_89958031	0.24	Tiam1	T cell lymphoma invasion and metastasis 1	1848	0.47
chr16_20692791_20694082	0.24	Fam131a	family with sequence similarity 131, member A	156	0.88
chr2_160367750_160367926	0.24	Mafb	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	773	0.73
chr18_73696846_73697208	0.23	Smad4	SMAD family member 4	6753	0.16
chr5_21865389_21865953	0.23	Slc26a5	solute carrier family 26, member 5	67	0.96
chr14_78678524_78678680	0.23	Gm18368	predicted gene, 18368	25208	0.16
chr4_91376198_91376448	0.23	Elavl2	ELAV like RNA binding protein 1	16	0.98
chr18_64889550_64889704	0.23	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	598	0.62
chr2_59438620_59439113	0.23	Gm13549	predicted gene 13549	39085	0.13
chr14_84437974_84438125	0.23	Pcdh17	protocadherin 17	5514	0.26
chr9_120098696_120098847	0.23	Gm47050	predicted gene, 47050	3108	0.11
chr19_46643484_46643643	0.23	Wbp1l	WW domain binding protein 1 like	20162	0.11
chr3_31026652_31026803	0.23	Prkci	protein kinase C, iota	4995	0.18
chr9_78504198_78504349	0.23	Eef1a1	eukaryotic translation elongation factor 1 alpha 1	15122	0.11
chr18_65393136_65393441	0.23	Alpk2	alpha-kinase 2	606	0.6
chr15_44752328_44752563	0.23	Sybu	syntabulin (syntaxin-interacting)	13	0.67
chr13_98534689_98535089	0.23	Gm37425	predicted gene, 37425	16951	0.12
chr9_4794566_4795419	0.22	Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	527	0.88
chr9_117870768_117871285	0.22	Rbms3	RNA binding motif, single stranded interacting protein	1558	0.39
chr10_71127422_71127648	0.22	Bicc1	BicC family RNA binding protein 1	19325	0.12
chr17_64346137_64346566	0.22	Pja2	praja ring finger ubiquitin ligase 2	14435	0.23
chr4_53442042_53442694	0.22	Slc44a1	solute carrier family 44, member 1	1684	0.42
chr19_25343674_25344266	0.22	Gm34432	predicted gene, 34432	3233	0.31
chr14_91896039_91896190	0.22	Gm48943	predicted gene, 48943	219666	0.02
chr18_69563797_69564227	0.22	Tcf4	transcription factor 4	677	0.76
chr4_117913262_117913510	0.22	Ipo13	importin 13	1613	0.23
chr12_72285979_72286146	0.22	Rtn1	reticulon 1	49338	0.15
chr19_28165559_28166176	0.22	Gm35781	predicted gene, 35781	19564	0.23
chr2_60036508_60037747	0.22	Gm13572	predicted gene 13572	14	0.98
chr1_189910816_189911265	0.22	Gm38245	predicted gene, 38245	4919	0.19
chr4_47609604_47609755	0.22	Sec61b	Sec61 beta subunit	134731	0.05
chr14_31662695_31662846	0.22	Hacl1	2-hydroxyacyl-CoA lyase 1	21484	0.13
chr10_102515341_102515492	0.21	Rassf9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	3160	0.25
chr5_83352776_83353067	0.21	Tecrl	trans-2,3-enoyl-CoA reductase-like	2035	0.43
chr6_54539408_54539559	0.21	Scrn1	secernin 1	14963	0.17
chr1_163301248_163301399	0.21	Gm37644	predicted gene, 37644	7744	0.18
chr10_60800688_60800996	0.21	Gm19972	predicted gene, 19972	13481	0.18
chr17_17910234_17910768	0.21	Gm7535	predicted gene 7535	2315	0.16
chr8_22508392_22509319	0.21	Slc20a2	solute carrier family 20, member 2	2629	0.22
chr2_64074730_64075670	0.21	Fign	fidgetin	22788	0.29
chr3_102224536_102224803	0.21	Vangl1	VANGL planar cell polarity 1	19976	0.13
chr2_112591399_112591550	0.21	Gm44374	predicted gene, 44374	22556	0.16
chr12_117163848_117163999	0.21	Gm10421	predicted gene 10421	12272	0.28
chr13_32008957_32009151	0.21	Gm35732	predicted gene, 35732	37968	0.18
chr2_63454866_63455043	0.21	Gm23503	predicted gene, 23503	22760	0.24
chr8_66700179_66700330	0.21	Npy1r	neuropeptide Y receptor Y1	2832	0.28
chr10_112270073_112271254	0.21	Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2	458	0.85
chr9_44877057_44877237	0.21	Gm39326	predicted gene, 39326	744	0.44
chr9_66004589_66004841	0.21	Csnk1g1	casein kinase 1, gamma 1	3025	0.23
chr11_96297868_96298678	0.20	Hoxb6	homeobox B6	898	0.3
chr9_45370028_45371246	0.20	Fxyd6	FXYD domain-containing ion transport regulator 6	195	0.91
chr6_8952771_8953600	0.20	Nxph1	neurexophilin 1	3509	0.38
chr19_14591939_14592995	0.20	Tle4	transducin-like enhancer of split 4	3072	0.36
chr2_6868272_6868550	0.20	Celf2	CUGBP, Elav-like family member 2	3561	0.25
chr15_85676712_85677176	0.20	Lncppara	long noncoding RNA near Ppara	23328	0.12
chr6_51844040_51844803	0.20	Skap2	src family associated phosphoprotein 2	27508	0.2
chr10_120721676_120722691	0.20	Gm37505	predicted gene, 37505	9632	0.13
chr2_10008087_10008238	0.20	C630004M23Rik	RIKEN cDNA C630004M23 gene	39676	0.09
chr14_49176028_49176179	0.20	Naa30	N(alpha)-acetyltransferase 30, NatC catalytic subunit	1796	0.31
chr17_44623731_44624125	0.20	n-R5s27	nuclear encoded rRNA 5S 27	17215	0.22
chr8_121730928_121732115	0.20	Jph3	junctophilin 3	954	0.49
chr14_64834470_64835221	0.20	Gm20111	predicted gene, 20111	4255	0.18
chr3_53043747_53045351	0.20	Gm42901	predicted gene 42901	2794	0.16
chr11_88619965_88620857	0.20	Msi2	musashi RNA-binding protein 2	30264	0.2
chr19_36118883_36119585	0.20	Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	676	0.71
chr6_86032524_86032675	0.20	Add2	adducin 2 (beta)	3852	0.13
chr17_22339851_22340002	0.20	Gm49951	predicted gene, 49951	6932	0.15
chr18_38598277_38598596	0.20	Spry4	sprouty RTK signaling antagonist 4	2979	0.2
chr17_79451074_79451933	0.19	Cdc42ep3	CDC42 effector protein (Rho GTPase binding) 3	96412	0.07
chr4_5645693_5646152	0.19	Fam110b	family with sequence similarity 110, member B	1687	0.36
chr2_137356841_137357676	0.19	Gm14055	predicted gene 14055	68755	0.13
chr2_9869939_9870090	0.19	Gata3	GATA binding protein 3	3658	0.15
chr3_87767082_87768667	0.19	Pear1	platelet endothelial aggregation receptor 1	1061	0.43
chr16_72905751_72905902	0.19	Robo1	roundabout guidance receptor 1	70523	0.14
chrX_51678767_51679193	0.19	Hs6st2	heparan sulfate 6-O-sulfotransferase 2	1585	0.48
chr16_46493311_46493865	0.19	Nectin3	nectin cell adhesion molecule 3	3184	0.34
chr4_25796073_25796399	0.19	Fut9	fucosyltransferase 9	3619	0.24
chr14_110753127_110753447	0.19	Slitrk6	SLIT and NTRK-like family, member 6	1862	0.32
chr7_54835204_54836499	0.19	Luzp2	leucine zipper protein 2	236	0.94
chr7_122044795_122044946	0.19	Ears2	glutamyl-tRNA synthetase 2, mitochondrial	22141	0.1
chrX_159259045_159259196	0.19	Rps6ka3	ribosomal protein S6 kinase polypeptide 3	2994	0.34
chr5_25098295_25098663	0.19	Prkag2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	2163	0.24
chr4_46202294_46203178	0.19	Xpa	xeroderma pigmentosum, complementation group A	6425	0.17
chr8_84770692_84772567	0.19	Nfix	nuclear factor I/X	1767	0.22
chr6_138365294_138365445	0.19	Lmo3	LIM domain only 3	56083	0.13
chr5_75247144_75247638	0.19	Gm42799	predicted gene 42799	948	0.57
chr3_79576778_79577000	0.19	Gm35067	predicted gene, 35067	5699	0.12
chr17_22360731_22361353	0.19	Zfp944	zinc finger protein 944	358	0.51
chr18_41860653_41861741	0.19	Gm50410	predicted gene, 50410	13637	0.22
chr9_76014472_76015728	0.18	Hmgcll1	3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1	45	0.55
chr1_83517764_83517915	0.18	Gm37989	predicted gene, 37989	90441	0.08
chr4_23829464_23829682	0.18	Gm28448	predicted gene 28448	104381	0.08
chr10_24312237_24312511	0.18	Moxd1	monooxygenase, DBH-like 1	88829	0.07
chr9_101401666_101401952	0.18	Gm24638	predicted gene, 24638	8699	0.18
chr19_36115709_36115956	0.18	Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	4078	0.23
chr6_92532985_92533460	0.18	Prickle2	prickle planar cell polarity protein 2	1639	0.46
chr6_116056244_116057282	0.18	Tmcc1	transmembrane and coiled coil domains 1	192	0.94
chr6_48626698_48627876	0.18	AI854703	expressed sequence AI854703	6	0.93
chr18_54984578_54984982	0.18	Zfp608	zinc finger protein 608	5386	0.22
chr9_45404342_45404493	0.18	Fxyd2	FXYD domain-containing ion transport regulator 2	441	0.75
chr14_79450824_79451101	0.18	Kbtbd6	kelch repeat and BTB (POZ) domain containing 6	873	0.51
chr2_74694827_74695683	0.18	Gm14396	predicted gene 14396	265	0.7
chr13_59431296_59431956	0.18	4930455M05Rik	RIKEN cDNA 4930455M05 gene	12229	0.14
chr11_81148614_81148842	0.18	Asic2	acid-sensing (proton-gated) ion channel 2	4593	0.3
chr6_128596921_128597883	0.18	Gm44009	predicted gene, 44009	9377	0.09
chr6_32584464_32585789	0.18	Plxna4	plexin A4	3066	0.3
chr1_23490467_23490664	0.17	Gm7784	predicted gene 7784	11026	0.24
chr8_50120264_50120415	0.17	Gm45323	predicted gene 45323	106955	0.07

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.3	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.2	1.1	GO:0042118	endothelial cell activation(GO:0042118)
0.1	0.4	GO:0071492	cellular response to UV-A(GO:0071492)
0.1	0.4	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.6	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.1	0.6	GO:0090527	actin filament reorganization(GO:0090527)
0.1	0.2	GO:0015755	fructose transport(GO:0015755)
0.1	0.3	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1	0.8	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1	0.3	GO:0060155	platelet dense granule organization(GO:0060155)
0.1	0.2	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.2	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.1	0.3	GO:2000821	regulation of grooming behavior(GO:2000821)
0.1	0.2	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1	0.3	GO:0070842	aggresome assembly(GO:0070842)
0.1	0.2	GO:0035284	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1	0.2	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1	0.2	GO:0060005	vestibular reflex(GO:0060005)
0.1	0.2	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.2	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.2	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.2	GO:0019532	oxalate transport(GO:0019532)
0.0	0.1	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
0.0	0.1	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0	0.1	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.0	0.1	GO:0036151	phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0	0.2	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.3	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.2	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.0	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.3	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.2	GO:0008616	queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.2	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.0	GO:0097051	establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.0	0.2	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.1	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.3	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.1	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.1	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.2	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.2	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.1	GO:0035564	regulation of kidney size(GO:0035564)
0.0	0.0	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.1	GO:0046391	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.1	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0090394	negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0	0.1	GO:0061110	dense core granule biogenesis(GO:0061110)
0.0	0.0	GO:1900451	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.2	GO:0071420	cellular response to histamine(GO:0071420)
0.0	0.1	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.1	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.0	0.1	GO:0048677	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0	0.1	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.1	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.0	0.1	GO:0071313	cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.0	0.1	GO:0002930	trabecular meshwork development(GO:0002930)
0.0	0.1	GO:1903797	positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.0	0.1	GO:0021590	cerebellum maturation(GO:0021590)
0.0	0.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.0	0.1	GO:0060618	nipple development(GO:0060618)
0.0	0.2	GO:0071732	cellular response to nitric oxide(GO:0071732)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0033762	response to glucagon(GO:0033762)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.0	0.1	GO:0035995	detection of muscle stretch(GO:0035995)
0.0	0.2	GO:0035584	calcium-mediated signaling using intracellular calcium source(GO:0035584)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.2	GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:2000392	regulation of lamellipodium morphogenesis(GO:2000392) positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0	0.0	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.0	0.1	GO:0080009	mRNA methylation(GO:0080009)
0.0	0.2	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.1	GO:0042160	lipoprotein modification(GO:0042160) lipoprotein oxidation(GO:0042161)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.0	0.0	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.0	0.1	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0003133	BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134)
0.0	0.3	GO:0051968	positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.2	GO:0070257	positive regulation of mucus secretion(GO:0070257)
0.0	0.0	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.0	0.2	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0	0.0	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	0.1	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.0	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0006183	GTP biosynthetic process(GO:0006183)
0.0	0.1	GO:0021776	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.1	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.0	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.0	GO:0072262	metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0	0.1	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0	0.1	GO:1990592	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0	0.1	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.0	0.2	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0	0.0	GO:0061091	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.0	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.0	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.0	GO:0035910	ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.0	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.0	GO:0048194	Golgi vesicle budding(GO:0048194)
0.0	0.0	GO:0002540	leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.0	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.0	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0071625	vocalization behavior(GO:0071625)
0.0	0.0	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0042373	vitamin K metabolic process(GO:0042373)
0.0	0.1	GO:0015822	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0	0.0	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.0	GO:0061042	vascular wound healing(GO:0061042)
0.0	0.0	GO:0099558	maintenance of synapse structure(GO:0099558)
0.0	0.1	GO:0001927	exocyst assembly(GO:0001927)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.0	GO:0050975	sensory perception of touch(GO:0050975)
0.0	0.1	GO:0071321	cellular response to cGMP(GO:0071321)
0.0	0.2	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.3	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0060903	positive regulation of meiosis I(GO:0060903)
0.0	0.2	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.0	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.1	GO:2000773	negative regulation of cellular senescence(GO:2000773)
0.0	0.0	GO:0030205	dermatan sulfate metabolic process(GO:0030205)
0.0	0.1	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.0	GO:1903286	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.0	GO:0060931	sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0	0.1	GO:0014883	transition between fast and slow fiber(GO:0014883)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.0	0.0	GO:1904526	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.2	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.1	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0035907	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:1903887	motile primary cilium assembly(GO:1903887)
0.0	0.0	GO:0014028	notochord formation(GO:0014028)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0060482	lobar bronchus development(GO:0060482)
0.0	0.1	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.1	GO:0036065	fucosylation(GO:0036065)
0.0	0.1	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading(GO:1900025)
0.0	0.0	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.0	0.0	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.0	GO:0060112	generation of ovulation cycle rhythm(GO:0060112)
0.0	0.0	GO:0033026	negative regulation of mast cell apoptotic process(GO:0033026)
0.0	0.0	GO:0050705	regulation of interleukin-1 alpha secretion(GO:0050705)
0.0	0.0	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.0	GO:0090032	negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0	0.0	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0	0.0	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.0	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.0	0.0	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0	0.0	GO:0043137	DNA replication, removal of RNA primer(GO:0043137)
0.0	0.0	GO:0070671	response to interleukin-12(GO:0070671)
0.0	0.1	GO:0031987	locomotion involved in locomotory behavior(GO:0031987)
0.0	0.1	GO:0009445	putrescine metabolic process(GO:0009445)
0.0	0.0	GO:0060988	lipid tube assembly(GO:0060988)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.1	GO:1990761	growth cone lamellipodium(GO:1990761)
0.2	GO:0044316	cone cell pedicle(GO:0044316)
0.3	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.1	GO:0097443	sorting endosome(GO:0097443)
0.5	GO:0071565	nBAF complex(GO:0071565)
0.4	GO:0031083	BLOC-1 complex(GO:0031083)
0.3	GO:0097449	astrocyte projection(GO:0097449)
0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.1	GO:1990716	axonemal central apparatus(GO:1990716)
0.1	GO:0097433	dense body(GO:0097433)
0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1	GO:0035838	growing cell tip(GO:0035838)
0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.2	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.1	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2	GO:0043083	synaptic cleft(GO:0043083)
0.1	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.1	GO:0030891	VCB complex(GO:0030891)
0.3	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.3	GO:0043034	costamere(GO:0043034)
0.1	GO:0030314	junctional membrane complex(GO:0030314)
0.2	GO:0060091	kinocilium(GO:0060091)
0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.1	GO:0070847	core mediator complex(GO:0070847)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.1	GO:1990246	uniplex complex(GO:1990246)
0.1	GO:0005688	U6 snRNP(GO:0005688)
0.1	GO:0005883	neurofilament(GO:0005883)
0.6	GO:0042734	presynaptic membrane(GO:0042734)
0.4	GO:0055038	recycling endosome membrane(GO:0055038)
0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.4	GO:0031941	filamentous actin(GO:0031941)
0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.1	GO:0030991	intraciliary transport particle A(GO:0030991)
0.1	GO:0097470	ribbon synapse(GO:0097470)
0.0	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.2	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2	GO:0005922	connexon complex(GO:0005922)
0.0	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	GO:0005614	interstitial matrix(GO:0005614)
0.1	GO:0098533	ATPase dependent transmembrane transport complex(GO:0098533)
0.1	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	GO:0044308	axonal spine(GO:0044308)
0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.1	GO:0005861	troponin complex(GO:0005861)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.1	0.3	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1	0.4	GO:0097001	ceramide binding(GO:0097001)
0.1	0.6	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.1	0.4	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1	0.4	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.2	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.3	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.0	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0	0.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.5	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.4	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.2	GO:0031432	titin binding(GO:0031432)
0.0	0.2	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.1	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.3	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0034824	enoyl-[acyl-carrier-protein] reductase activity(GO:0016631) 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity(GO:0018498) cis-2,3-dihydrodiol DDT dehydrogenase activity(GO:0018499) trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity(GO:0018500) cis-chlorobenzene dihydrodiol dehydrogenase activity(GO:0018501) 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity(GO:0018502) trans-1,2-dihydrodiolphenanthrene dehydrogenase activity(GO:0018503) 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity(GO:0034790) benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity(GO:0034805) benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity(GO:0034809) citronellyl-CoA dehydrogenase activity(GO:0034824) menthone dehydrogenase activity(GO:0034838) phthalate 3,4-cis-dihydrodiol dehydrogenase activity(GO:0034912) cinnamate reductase activity(GO:0043786) NADPH-dependent curcumin reductase activity(GO:0052849) NADPH-dependent dihydrocurcumin reductase activity(GO:0052850)
0.0	0.0	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.0	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.1	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.2	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.3	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.4	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0008251	tRNA-specific adenosine deaminase activity(GO:0008251)
0.0	0.1	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.4	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.3	GO:0004623	phospholipase A2 activity(GO:0004623)
0.0	0.2	GO:0031402	sodium ion binding(GO:0031402)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0098988	G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.0	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.0	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0004549	tRNA-specific ribonuclease activity(GO:0004549)
0.0	0.1	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.4	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.1	GO:0031005	filamin binding(GO:0031005)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.0	GO:0038064	collagen receptor activity(GO:0038064)
0.0	0.0	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0051765	inositol tetrakisphosphate kinase activity(GO:0051765)
0.0	0.1	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.3	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.0	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.2	GO:0004118	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.0	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.0	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.5	PID FGF PATHWAY	FGF signaling pathway
0.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID NECTIN PATHWAY	Nectin adhesion pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
1.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	REACTOME CELL CELL COMMUNICATION	Genes involved in Cell-Cell communication
0.4	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.4	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.4	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins