Project
ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Gbx2

Z-value: 0.71

Motif logo

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Transcription factors associated with Gbx2

Gene Symbol Gene ID Gene Info
ENSMUSG00000034486.7 Gbx2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
Gbx2chr1_89939935_8994064791120.195560-0.311.7e-02Click!
Gbx2chr1_89921735_8992388063780.208198-0.282.7e-02Click!
Gbx2chr1_89942989_89943140118850.189360-0.246.7e-02Click!
Gbx2chr1_89941432_89942704108890.191430-0.238.0e-02Click!
Gbx2chr1_89939435_8993958683310.197710-0.229.7e-02Click!

Activity of the Gbx2 motif across conditions

Conditions sorted by the z-value of the Gbx2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chrX_21484558_21485279 1.53 Agtr2
angiotensin II receptor, type 2
196
0.94
chr16_88599651_88600158 1.31 Gm49688
predicted gene, 49688
8766
0.11
chr2_74696421_74697223 1.18 Gm28793
predicted gene 28793
764
0.23
chr7_49907312_49908741 1.17 Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
2120
0.4
chrX_58035394_58035659 1.08 Zic3
zinc finger protein of the cerebellum 3
4516
0.29
chr12_77791074_77791423 1.08 Gm24070
predicted gene, 24070
23561
0.2
chr12_41483283_41485192 1.05 Lrrn3
leucine rich repeat protein 3, neuronal
2194
0.36
chr16_74407688_74408034 1.04 Robo2
roundabout guidance receptor 2
3051
0.35
chr9_74869680_74869831 1.02 Onecut1
one cut domain, family member 1
3271
0.2
chr6_52216788_52218128 1.01 Hoxa7
homeobox A7
6
0.91
chr14_84450287_84451113 1.00 Pcdh17
protocadherin 17
2193
0.37
chr16_88561792_88563295 0.98 Cldn8
claudin 8
640
0.64
chr3_20365498_20365649 0.88 Agtr1b
angiotensin II receptor, type 1b
1551
0.38
chr2_11884018_11884169 0.86 Gm34768
predicted gene, 34768
15989
0.23
chr16_81203532_81203683 0.86 Ncam2
neural cell adhesion molecule 2
2850
0.36
chr10_126169548_126169835 0.85 Gm4510
predicted gene 4510
16632
0.26
chr5_131585523_131586662 0.85 Gm27266
predicted gene, 27266
8105
0.13
chr14_122480308_122481080 0.84 Zic2
zinc finger protein of the cerebellum 2
2594
0.16
chr3_5224377_5225076 0.83 Zfhx4
zinc finger homeodomain 4
3221
0.24
chr6_52211753_52213405 0.81 Hoxa3
homeobox A3
536
0.36
chr4_62966572_62967137 0.81 Zfp618
zinc finger protein 618
1280
0.42
chr4_154630838_154632339 0.80 Prdm16
PR domain containing 16
5209
0.14
chr4_22485441_22485749 0.77 Pou3f2
POU domain, class 3, transcription factor 2
2771
0.23
chr12_40449188_40449922 0.77 Dock4
dedicator of cytokinesis 4
3219
0.27
chr12_51000370_51001072 0.76 Gm40421
predicted gene, 40421
4152
0.24
chr8_114707514_114708076 0.76 Gm16118
predicted gene 16118
211
0.95
chr10_109008310_109009456 0.76 Syt1
synaptotagmin I
217
0.96
chr5_43240853_43241007 0.75 Cpeb2
cytoplasmic polyadenylation element binding protein 2
3615
0.18
chr9_41578714_41578969 0.74 Mir100hg
Mir100 Mirlet7a-2 Mir125b-1 cluster host gene
653
0.53
chr9_103112824_103112975 0.74 Rab6b
RAB6B, member RAS oncogene family
1092
0.45
chr13_44026235_44027511 0.74 Gm33489
predicted gene, 33489
8351
0.22
chr14_99301075_99301422 0.74 Klf5
Kruppel-like factor 5
2094
0.28
chr15_103058659_103059955 0.73 5730585A16Rik
RIKEN cDNA 5730585A16 gene
1
0.95
chr1_115688816_115689173 0.73 Cntnap5a
contactin associated protein-like 5A
4238
0.28
chr2_22738184_22738444 0.72 1700092C17Rik
RIKEN cDNA 1700092C17 gene
17670
0.13
chr2_155590226_155590377 0.72 Gssos2
glutathione synthase, opposite strand 2
830
0.34
chr2_116051067_116051481 0.72 Meis2
Meis homeobox 2
1594
0.37
chr15_102948559_102948937 0.71 Hotair
HOX transcript antisense RNA (non-protein coding)
1018
0.31
chr13_63278777_63280117 0.71 Gm47602
predicted gene, 47602
223
0.69
chr1_124043338_124043489 0.71 Dpp10
dipeptidylpeptidase 10
1750
0.52
chr3_17326564_17327148 0.71 Gm30340
predicted gene, 30340
7569
0.24
chr15_99056560_99057587 0.70 Prph
peripherin
1103
0.3
chr7_62416059_62417205 0.69 Mkrn3
makorin, ring finger protein, 3
3507
0.2
chr3_38894285_38895428 0.67 Fat4
FAT atypical cadherin 4
3914
0.27
chr17_91090702_91091377 0.67 Nrxn1
neurexin I
1694
0.28
chr12_108424381_108424697 0.67 Eml1
echinoderm microtubule associated protein like 1
1461
0.41
chr16_77594640_77595970 0.67 Mir99ahg
Mir99a and Mirlet7c-1 host gene (non-protein coding)
403
0.71
chr15_32923267_32923822 0.67 Sdc2
syndecan 2
2821
0.38
chr10_72299004_72299155 0.67 Gm9923
predicted pseudogene 9923
10242
0.31
chr6_52252411_52254268 0.67 9530018H14Rik
RIKEN cDNA 9530018H14 gene
4121
0.07
chr5_144483749_144483900 0.65 Nptx2
neuronal pentraxin 2
62078
0.11
chr3_55778948_55779699 0.64 Mab21l1
mab-21-like 1
3187
0.25
chr13_47566403_47566695 0.64 4930471G24Rik
RIKEN cDNA 4930471G24 gene
101001
0.08
chr9_30918491_30920140 0.64 Adamts15
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
1635
0.4
chr19_20009817_20010437 0.64 Gm22684
predicted gene, 22684
23508
0.22
chr17_22760154_22760305 0.64 Gm5493
predicted gene 5493
20284
0.13
chr9_91359026_91359334 0.64 Zic4
zinc finger protein of the cerebellum 4
3233
0.14
chr8_125914178_125914599 0.64 Map3k21
mitogen-activated protein kinase kinase kinase 21
3938
0.22
chr4_118288250_118288401 0.64 Ptprf
protein tyrosine phosphatase, receptor type, F
2949
0.24
chr4_33926104_33927188 0.63 Cnr1
cannabinoid receptor 1 (brain)
444
0.88
chr12_29529828_29531185 0.63 Gm20208
predicted gene, 20208
609
0.74
chr8_79372300_79372589 0.62 Smad1
SMAD family member 1
15766
0.17
chr1_182823768_182824187 0.62 Susd4
sushi domain containing 4
59082
0.11
chr6_52224853_52226609 0.62 Hoxa9
homeobox A9
458
0.51
chr10_97609680_97609831 0.62 Kera
keratocan
2876
0.22
chr1_136228373_136230942 0.62 Inava
innate immunity activator
362
0.76
chr1_74892200_74893701 0.62 Cryba2
crystallin, beta A2
58
0.95
chr5_53052069_53052288 0.61 Slc34a2
solute carrier family 34 (sodium phosphate), member 2
2825
0.22
chr7_29496118_29496269 0.61 Sipa1l3
signal-induced proliferation-associated 1 like 3
9259
0.16
chrX_7739896_7741560 0.61 Ccdc120
coiled-coil domain containing 120
497
0.57
chr16_43235566_43236569 0.60 Zbtb20
zinc finger and BTB domain containing 20
28
0.98
chr3_33269889_33270040 0.60 Gm27974
predicted gene, 27974
9144
0.2
chr16_67610470_67610655 0.60 Cadm2
cell adhesion molecule 2
9931
0.25
chr2_22626092_22626243 0.59 Gad2
glutamic acid decarboxylase 2
2863
0.19
chr15_103009345_103011570 0.59 Hoxc6
homeobox C6
884
0.35
chr7_79507974_79509311 0.58 A330074H02Rik
RIKEN cDNA A330074H02 gene
1720
0.18
chr3_29957475_29957868 0.58 Gm37281
predicted gene, 37281
31135
0.15
chr8_45688068_45688642 0.58 Sorbs2
sorbin and SH3 domain containing 2
18
0.98
chr15_25408835_25409622 0.58 Basp1
brain abundant, membrane attached signal protein 1
4470
0.17
chr11_96282910_96285155 0.58 Hoxb8
homeobox B8
1307
0.19
chr2_28910187_28910661 0.57 Barhl1
BarH like homeobox 1
2071
0.29
chr1_78186833_78187893 0.57 Pax3
paired box 3
9475
0.23
chr15_32780266_32781493 0.57 Gm32618
predicted gene, 32618
1975
0.38
chr15_103105552_103105797 0.56 Gm28265
predicted gene 28265
1072
0.32
chr11_120242307_120244045 0.56 Bahcc1
BAH domain and coiled-coil containing 1
6477
0.1
chr6_107711293_107711898 0.55 4933431M02Rik
RIKEN cDNA 4933431M02 gene
83821
0.1
chr6_42707641_42707961 0.55 Tcaf1
TRPM8 channel-associated factor 1
2270
0.16
chr5_7342956_7343453 0.55 Zfp804b
zinc finger protein 804B
1552
0.41
chr18_69595338_69595620 0.54 Tcf4
transcription factor 4
1297
0.56
chr5_84413029_84413589 0.54 Epha5
Eph receptor A5
3497
0.31
chr14_104030791_104030942 0.54 4930432J09Rik
RIKEN cDNA 4930432J09 gene
3724
0.34
chr8_12915306_12916734 0.54 Mcf2l
mcf.2 transforming sequence-like
45
0.76
chr11_86605282_86605433 0.54 Vmp1
vacuole membrane protein 1
3062
0.2
chr7_48961270_48961876 0.54 Nav2
neuron navigator 2
2476
0.25
chr12_73997086_73997237 0.53 Syt16
synaptotagmin XVI
500
0.77
chr5_47796679_47796830 0.53 Gm3010
predicted gene 3010
96909
0.08
chr9_118199526_118199677 0.53 Gm17399
predicted gene, 17399
49370
0.14
chr17_90452047_90452824 0.53 Nrxn1
neurexin I
2387
0.31
chr9_52500605_52500756 0.53 Gm49389
predicted gene, 49389
96381
0.07
chr2_167540595_167541629 0.52 Snai1
snail family zinc finger 1
2917
0.16
chr3_45204718_45204869 0.52 Gm27989
predicted gene, 27989
44098
0.15
chr3_95163200_95164363 0.52 Sema6c
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
525
0.54
chr6_144202688_144204608 0.52 Sox5
SRY (sex determining region Y)-box 5
409
0.92
chr12_12937582_12937733 0.51 Mycn
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
2959
0.18
chr5_114569026_114570120 0.51 Fam222a
family with sequence similarity 222, member A
1556
0.35
chr19_41739688_41740472 0.51 Slit1
slit guidance ligand 1
3406
0.26
chr1_157798825_157799345 0.51 Gm38256
predicted gene, 38256
141300
0.04
chr7_62208910_62209522 0.51 Gm9801
predicted gene 9801
263
0.94
chr2_165596319_165596667 0.51 Eya2
EYA transcriptional coactivator and phosphatase 2
1461
0.39
chr1_62704948_62705819 0.51 Nrp2
neuropilin 2
1681
0.35
chr6_52196485_52198020 0.51 Hoxaas3
Hoxa cluster antisense RNA 3
3872
0.06
chr17_64206242_64206631 0.50 Pja2
praja ring finger ubiquitin ligase 2
106595
0.07
chr15_95525022_95525792 0.50 Nell2
NEL-like 2
2771
0.35
chr8_100228228_100228379 0.50 Gm5742
predicted gene 5742
168187
0.04
chr2_153440130_153440281 0.50 Nol4l
nucleolar protein 4-like
4274
0.2
chr13_51408385_51410292 0.50 S1pr3
sphingosine-1-phosphate receptor 3
699
0.69
chr8_89288677_89288828 0.50 Gm5356
predicted pseudogene 5356
101192
0.08
chr5_147303898_147304049 0.50 Cdx2
caudal type homeobox 2
3297
0.13
chr6_37645617_37646179 0.50 Ybx1-ps2
Y box protein 1, pseudogene 2
41297
0.18
chr8_48136896_48137754 0.49 Dctd
dCMP deaminase
27114
0.2
chr11_95597886_95598472 0.49 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
10444
0.16
chr16_72811501_72811652 0.49 Robo1
roundabout guidance receptor 1
148372
0.05
chr14_118435860_118436192 0.49 Gm5672
predicted gene 5672
59832
0.09
chr17_68836792_68837954 0.49 Gm38593
predicted gene, 38593
147
0.62
chr9_122597077_122597558 0.49 9530059O14Rik
RIKEN cDNA 9530059O14 gene
24815
0.12
chr1_41605412_41605563 0.48 Gm28634
predicted gene 28634
75944
0.12
chr1_138837882_138838896 0.48 Lhx9
LIM homeobox protein 9
4040
0.18
chr18_69349496_69350227 0.48 Tcf4
transcription factor 4
917
0.69
chr4_126150157_126151254 0.47 Eva1b
eva-1 homolog B (C. elegans)
2173
0.18
chr5_120433178_120434996 0.47 Gm27199
predicted gene 27199
2320
0.19
chr12_59129998_59130231 0.47 Mia2
MIA SH3 domain ER export factor 2
263
0.88
chr10_92161472_92161916 0.46 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
1067
0.55
chr6_52176961_52178435 0.46 5730596B20Rik
RIKEN cDNA 5730596B20 gene
200
0.79
chr9_63139436_63140636 0.46 Gm25064
predicted gene, 25064
6753
0.18
chr12_84493482_84493633 0.46 Lin52
lin-52 homolog (C. elegans)
36161
0.11
chr13_83713464_83713615 0.46 C130071C03Rik
RIKEN cDNA C130071C03 gene
7842
0.14
chr3_26331036_26332158 0.46 Nlgn1
neuroligin 1
273
0.58
chr7_5056231_5057716 0.46 Gm15510
predicted gene 15510
53
0.48
chr4_150270799_150270951 0.45 Rere
arginine glutamic acid dipeptide (RE) repeats
10771
0.14
chr2_169178799_169179344 0.45 9430093N23Rik
RIKEN cDNA 9430093N23 gene
55920
0.13
chr5_67466735_67467291 0.45 C330024D21Rik
RIKEN cDNA C330024D21 gene
3110
0.19
chr12_52911080_52911262 0.45 Akap6
A kinase (PRKA) anchor protein 6
115335
0.06
chr3_17796058_17796354 0.45 Mir124-2hg
Mir124-2 host gene (non-protein coding)
462
0.52
chr1_62564755_62565185 0.45 Gm29084
predicted gene 29084
29028
0.18
chr2_52720638_52720837 0.45 Gm13548
predicted gene 13548
18718
0.18
chr11_78170207_78170358 0.44 Nek8
NIMA (never in mitosis gene a)-related expressed kinase 8
454
0.56
chr1_174920917_174922100 0.44 Grem2
gremlin 2, DAN family BMP antagonist
311
0.94
chr8_35883104_35883618 0.44 5430403N17Rik
RIKEN cDNA 5430403N17 gene
404
0.86
chr1_138835333_138836550 0.44 Lhx9
LIM homeobox protein 9
2282
0.24
chr7_28203492_28203757 0.44 Gm45011
predicted gene 45011
22734
0.08
chr7_133608062_133608429 0.44 Gm45671
predicted gene 45671
19
0.96
chr5_33723808_33724192 0.44 Fgfr3
fibroblast growth factor receptor 3
228
0.59
chr19_60148618_60149048 0.44 E330013P04Rik
RIKEN cDNA E330013P04 gene
2461
0.3
chr8_61309431_61310318 0.43 1700001D01Rik
RIKEN cDNA 1700001D01 gene
21002
0.18
chr13_67039116_67039380 0.43 4933433G19Rik
RIKEN cDNA 4933433G19 gene
6840
0.1
chr10_111247804_111248910 0.43 Osbpl8
oxysterol binding protein-like 8
289
0.91
chr3_148984296_148985724 0.43 Gm43573
predicted gene 43573
4142
0.2
chr19_58076835_58077494 0.43 Gm50287
predicted gene, 50287
18867
0.22
chr2_73777255_73777445 0.43 Chn1
chimerin 1
2004
0.35
chr3_110139298_110139994 0.43 Ntng1
netrin G1
3358
0.33
chr11_36674002_36674437 0.43 Tenm2
teneurin transmembrane protein 2
3526
0.35
chrX_12469610_12469761 0.43 Rpl30-ps11
ribosomal protein L30, pseudogene 11
12455
0.25
chr8_12428084_12429088 0.43 Gm25239
predicted gene, 25239
32183
0.11
chr12_46814495_46815083 0.43 Nova1
NOVA alternative splicing regulator 1
2171
0.31
chr13_72288993_72289292 0.43 Gm4052
predicted gene 4052
61079
0.13
chr14_67241509_67241827 0.43 Ebf2
early B cell factor 2
7024
0.17
chr15_25415436_25415919 0.43 Gm48957
predicted gene, 48957
614
0.58
chr3_138280115_138280773 0.42 Adh1
alcohol dehydrogenase 1 (class I)
2793
0.17
chr14_104640336_104640571 0.42 D130009I18Rik
RIKEN cDNA D130009I18 gene
1309
0.47
chr4_153480513_153480981 0.42 Ajap1
adherens junction associated protein 1
1432
0.58
chr11_22284673_22285000 0.42 Ehbp1
EH domain binding protein 1
1002
0.67
chr2_77701567_77703605 0.42 Zfp385b
zinc finger protein 385B
686
0.8
chr16_45098155_45099397 0.42 Ccdc80
coiled-coil domain containing 80
4723
0.24
chr2_31638722_31641540 0.42 Prdm12
PR domain containing 12
94
0.84
chr14_122479539_122479995 0.42 Zic2
zinc finger protein of the cerebellum 2
1667
0.23
chr9_78175193_78175344 0.42 C920006O11Rik
RIKEN cDNA C920006O11 gene
646
0.58
chr15_13067157_13068365 0.41 Gm24664
predicted gene, 24664
86932
0.08
chr11_103339490_103340754 0.41 Arhgap27
Rho GTPase activating protein 27
403
0.77
chr9_45433206_45433653 0.41 4833428L15Rik
RIKEN cDNA 4833428L15 gene
1699
0.26
chr13_58450895_58451149 0.41 Gm47918
predicted gene, 47918
8001
0.16
chr18_40260537_40261051 0.41 Kctd16
potassium channel tetramerisation domain containing 16
1991
0.29
chrX_94637542_94637693 0.41 Gspt2
G1 to S phase transition 2
1541
0.3
chr12_50121867_50122018 0.41 Gm40418
predicted gene, 40418
1633
0.56
chr15_78116860_78117881 0.41 A730060N03Rik
RIKEN cDNA A730060N03 gene
2336
0.22
chr18_13967357_13968027 0.41 Zfp521
zinc finger protein 521
4028
0.33
chr2_116053626_116054503 0.40 Meis2
Meis homeobox 2
4384
0.2
chr15_64916306_64916931 0.40 Adcy8
adenylate cyclase 8
5653
0.28
chr13_85067537_85067966 0.40 Gm47745
predicted gene, 47745
26584
0.17
chr2_33713186_33713886 0.40 9430024E24Rik
RIKEN cDNA 9430024E24 gene
5363
0.21
chr19_16437610_16437973 0.40 Gna14
guanine nucleotide binding protein, alpha 14
1509
0.37
chr19_28500495_28500646 0.40 Glis3
GLIS family zinc finger 3
39850
0.19
chr12_30370291_30370442 0.40 Sntg2
syntrophin, gamma 2
2899
0.33
chr2_121803106_121803474 0.40 Frmd5
FERM domain containing 5
3582
0.23
chr7_81341709_81341934 0.40 Rps17
ribosomal protein S17
2710
0.22
chr18_21654600_21655235 0.40 Klhl14
kelch-like 14
199
0.95
chr1_137088325_137088476 0.40 Gm23763
predicted gene, 23763
98130
0.07
chr5_5431980_5432131 0.40 Cdk14
cyclin-dependent kinase 14
11743
0.19
chr5_117841452_117842996 0.40 Nos1
nitric oxide synthase 1, neuronal
38
0.98
chr16_42337545_42337696 0.40 Gap43
growth associated protein 43
3031
0.33
chr14_89793420_89793784 0.40 Gm25415
predicted gene, 25415
86797
0.1

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of Gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0035564 regulation of kidney size(GO:0035564)
0.2 1.7 GO:0042118 endothelial cell activation(GO:0042118)
0.2 0.6 GO:0021564 vagus nerve development(GO:0021564)
0.2 0.6 GO:0060300 regulation of cytokine activity(GO:0060300)
0.2 0.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.5 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 0.5 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.2 0.9 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.1 0.4 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.6 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 0.5 GO:0097475 motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.1 0.4 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1 0.3 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.6 GO:0031999 negative regulation of fatty acid beta-oxidation(GO:0031999)
0.1 0.8 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.3 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.1 0.3 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 0.3 GO:0060523 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 0.3 GO:1903375 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 0.5 GO:0016198 axon choice point recognition(GO:0016198)
0.1 0.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.2 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.1 0.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.4 GO:0036233 glycine import(GO:0036233)
0.1 0.3 GO:0060594 mammary gland specification(GO:0060594)
0.1 0.3 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.1 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.4 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.2 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.1 0.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.2 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 0.5 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 0.2 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.1 0.3 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.1 0.2 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.1 0.2 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.1 0.1 GO:1902071 regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.1 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.1 0.3 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.1 GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0072108)
0.1 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.1 GO:0060435 bronchiole development(GO:0060435)
0.1 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.3 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.3 GO:0002035 brain renin-angiotensin system(GO:0002035)
0.1 0.2 GO:0072051 juxtaglomerular apparatus development(GO:0072051)
0.1 0.2 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1 0.3 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.1 0.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.2 GO:0097503 sialylation(GO:0097503)
0.1 0.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 0.1 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.4 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.1 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 0.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:0060847 endothelial cell fate specification(GO:0060847)
0.0 0.2 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0021546 rhombomere development(GO:0021546)
0.0 0.0 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.0 0.0 GO:0048880 sensory system development(GO:0048880)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.2 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 0.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0000101 sulfur amino acid transport(GO:0000101)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.1 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0007494 midgut development(GO:0007494)
0.0 0.2 GO:2000980 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.0 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.0 0.3 GO:0021936 regulation of cerebellar granule cell precursor proliferation(GO:0021936)
0.0 0.1 GO:0071681 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 0.0 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.1 GO:0002930 trabecular meshwork development(GO:0002930)
0.0 0.3 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.1 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.1 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.0 0.1 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.3 GO:0070633 transepithelial transport(GO:0070633)
0.0 0.3 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.4 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.2 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0097195 pilomotor reflex(GO:0097195)
0.0 0.1 GO:0071608 macrophage inflammatory protein-1 alpha production(GO:0071608)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.1 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.0 0.0 GO:2000599 regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0 0.0 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.0 GO:0061184 positive regulation of dermatome development(GO:0061184)
0.0 0.1 GO:0051594 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.0 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.0 0.1 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.0 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.1 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.0 GO:1902488 cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0 0.1 GO:0014744 positive regulation of muscle adaptation(GO:0014744)
0.0 0.1 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.0 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.0 GO:0035793 cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.3 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.0 GO:2000828 regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.0 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.4 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.0 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.0 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.0 GO:0021855 hypothalamus cell migration(GO:0021855)
0.0 0.0 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.0 0.2 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0032803 low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.3 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.1 GO:0072017 distal tubule development(GO:0072017)
0.0 0.1 GO:0098596 vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.0 0.0 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.0 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.1 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.0 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.1 GO:0007442 hindgut morphogenesis(GO:0007442)
0.0 0.1 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030)
0.0 0.0 GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0 0.0 GO:0021586 pons maturation(GO:0021586)
0.0 0.0 GO:0043096 purine nucleobase salvage(GO:0043096)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0019478 D-amino acid catabolic process(GO:0019478)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0015816 glycine transport(GO:0015816)
0.0 0.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0042473 outer ear morphogenesis(GO:0042473)
0.0 0.0 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 0.1 GO:0015838 amino-acid betaine transport(GO:0015838)
0.0 0.7 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.1 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 0.2 GO:0007625 grooming behavior(GO:0007625)
0.0 0.0 GO:0072203 cell proliferation involved in metanephros development(GO:0072203)
0.0 0.0 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 0.1 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.0 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.0 0.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.2 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.0 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.0 0.1 GO:0060973 cell migration involved in heart development(GO:0060973)
0.0 0.0 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003256)
0.0 0.0 GO:0045636 regulation of melanocyte differentiation(GO:0045634) positive regulation of melanocyte differentiation(GO:0045636)
0.0 0.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.1 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.1 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.0 0.0 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.0 0.0 GO:0021604 cranial nerve structural organization(GO:0021604)
0.0 0.0 GO:0045917 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0035247 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) peptidyl-arginine omega-N-methylation(GO:0035247)
0.0 0.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.0 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.0 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.0 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.0 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.2 GO:0007616 long-term memory(GO:0007616)
0.0 0.0 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015)
0.0 0.0 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.1 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0042428 serotonin metabolic process(GO:0042428)
0.0 0.0 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.0 0.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.1 GO:0061213 positive regulation of mesonephros development(GO:0061213)
0.0 0.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.0 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.0 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.0 0.0 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.0 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.0 GO:1990314 cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0 0.0 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087)
0.0 0.0 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.0 GO:1905065 positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0 0.0 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 0.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.0 GO:0072172 mesonephric tubule formation(GO:0072172)
0.0 0.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.0 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0 0.0 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.0 GO:1903525 regulation of membrane tubulation(GO:1903525)
0.0 0.1 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.0 GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0 0.0 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:2000171 negative regulation of dendrite development(GO:2000171)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.5 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0044299 C-fiber(GO:0044299)
0.1 0.2 GO:1990696 USH2 complex(GO:1990696)
0.0 0.7 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.5 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.3 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.0 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.3 GO:0000800 lateral element(GO:0000800)
0.0 0.0 GO:0035838 growing cell tip(GO:0035838)
0.0 0.0 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.0 GO:0005914 spot adherens junction(GO:0005914)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.0 GO:0005608 laminin-3 complex(GO:0005608)
0.0 0.2 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.0 GO:1990745 EARP complex(GO:1990745)
0.0 0.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.1 GO:0030427 site of polarized growth(GO:0030427)
0.0 0.0 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.0 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.0 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.2 0.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.6 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.2 0.5 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.3 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.1 0.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.4 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.3 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 0.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.6 GO:0036122 BMP binding(GO:0036122)
0.1 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.2 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.1 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.2 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.3 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.0 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.1 GO:0070878 primary miRNA binding(GO:0070878)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.3 GO:0052830 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.0 GO:0046978 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0 0.1 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.0 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.0 0.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 1.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 0.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.0 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.0 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0004673 protein histidine kinase activity(GO:0004673)
0.0 0.0 GO:0055100 adiponectin binding(GO:0055100)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 0.1 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.1 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.4 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.0 REACTOME SIGNALING BY FGFR IN DISEASE Genes involved in Signaling by FGFR in disease
0.0 0.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 2.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.0 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors