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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Glis1

Z-value: 0.25

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Transcription factors associated with Glis1

Gene Symbol Gene ID Gene Info
Glis1
ENSMUSG00000034762.3 Glis1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
Glis1chr4_107457367_107458506189380.161467-0.637.7e-08Click!
Glis1chr4_107458555_107458755196570.160617-0.481.1e-04Click!
Glis1chr4_107459273_107459544204100.159631-0.435.8e-04Click!
Glis1chr4_107458870_107459029199510.160263-0.428.2e-04Click!
Glis1chr4_107443262_10744375345090.193722-0.411.2e-03Click!

Activity of the Glis1 motif across conditions

Conditions sorted by the z-value of the Glis1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_84694736_84695168 1.31 Mir5126
 microRNA 5126
 887
 0.41
chr1_134232926_134233818 1.07 Adora1
 adenosine A1 receptor
 1206
 0.39
chr10_76960868_76961875 0.81 Pcbp3
 poly(rC) binding protein 3
 417
 0.81
chr8_117259792_117260803 0.81 Cmip
 c-Maf inducing protein
 3180
 0.33
chr10_77339253_77340474 0.74 Adarb1
 adenosine deaminase, RNA-specific, B1
 313
 0.91
chrX_60891819_60892374 0.60 Sox3
 SRY (sex determining region Y)-box 3
 1334
 0.33
chr18_64931481_64931680 0.59 Nedd4l
 neural precursor cell expressed, developmentally down-regulated gene 4-like
 10451
 0.21
chr15_45114048_45115133 0.56 Kcnv1
 potassium channel, subfamily V, member 1
 237
 0.95
chrX_74328574_74328761 0.55 Plxna3
 plexin A3
 399
 0.64
chr7_4546391_4547839 0.48 Syt5
 synaptotagmin V
 142
 0.89
chr9_112231189_112232055 0.47 Arpp21
 cyclic AMP-regulated phosphoprotein, 21
 280
 0.9
chr5_52114654_52115728 0.46 Gm43177
 predicted gene 43177
 2121
 0.23
chr9_47688636_47688874 0.37 Gm47198
 predicted gene, 47198
 82386
 0.09
chr7_47357377_47358685 0.33 Mrgpra1
 MAS-related GPR, member A1
 3791
 0.17
chr1_120340233_120341796 0.32 C1ql2
 complement component 1, q subcomponent-like 2
 432
 0.88
chr4_141623201_141623679 0.32 Slc25a34
 solute carrier family 25, member 34
 381
 0.76
chr5_33234965_33235220 0.28 Ctbp1
 C-terminal binding protein 1
 14158
 0.14
chr15_36790299_36790969 0.26 Ywhaz
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
 1780
 0.3
chr17_47759581_47759790 0.25 Tfeb
 transcription factor EB
 510
 0.69
chr4_82481887_82482038 0.24 Nfib
 nuclear factor I/B
 17354
 0.19
chr4_147969208_147969498 0.23 Nppb
 natriuretic peptide type B
 16435
 0.09
chr3_92689234_92689738 0.20 Gm4202
 predicted gene 4202
 60
 0.92
chr3_87763267_87765638 0.18 Pear1
 platelet endothelial aggregation receptor 1
 2238
 0.23
chr16_35155941_35156382 0.18 Adcy5
 adenylate cyclase 5
 1284
 0.52
chr5_27048872_27050274 0.16 Dpp6
 dipeptidylpeptidase 6
 180
 0.97
chr11_3289715_3290157 0.16 Patz1
 POZ (BTB) and AT hook containing zinc finger 1
 57
 0.96
chr9_41582824_41584205 0.16 Mir125b-1
 microRNA 125b-1
 1588
 0.2
chr10_77589724_77589999 0.14 Pttg1ip
 pituitary tumor-transforming 1 interacting protein
 467
 0.67
chr8_90347037_90348254 0.14 Tox3
 TOX high mobility group box family member 3
 481
 0.89
chr9_15043198_15043353 0.11 Panx1
 pannexin 1
 522
 0.79
chr16_91300793_91302112 0.10 Gm15966
 predicted gene 15966
 24288
 0.11
chr6_51438062_51438277 0.10 Nfe2l3
 nuclear factor, erythroid derived 2, like 3
 5420
 0.17
chrX_101418815_101419777 0.10 Zmym3
 zinc finger, MYM-type 3
 502
 0.72
chr9_120539607_120540979 0.10 Entpd3
 ectonucleoside triphosphate diphosphohydrolase 3
 475
 0.72
chr15_99673865_99674141 0.09 Asic1
 acid-sensing (proton-gated) ion channel 1
 1336
 0.24
chr10_67939481_67939695 0.09 Zfp365
 zinc finger protein 365
 26926
 0.16
chr10_40037096_40037418 0.09 Mfsd4b1
 major facilitator superfamily domain containing 4B1
 11989
 0.12
chr4_133887863_133888313 0.09 Rps6ka1
 ribosomal protein S6 kinase polypeptide 1
 291
 0.84
chr4_135569876_135571129 0.08 Grhl3
 grainyhead like transcription factor 3
 3128
 0.19
chr17_56159563_56159714 0.08 Tnfaip8l1
 tumor necrosis factor, alpha-induced protein 8-like 1
 2839
 0.13
chr3_87971097_87972446 0.07 Nes
 nestin
 642
 0.51
chr17_37045646_37045989 0.07 Gabbr1
 gamma-aminobutyric acid (GABA) B receptor, 1
 149
 0.9
chr7_4780097_4780248 0.07 Il11
 interleukin 11
 2031
 0.13
chr16_25407334_25407877 0.06 Gm18896
 predicted gene, 18896
 35668
 0.22
chr17_27039067_27039218 0.06 Ggnbp1
 gametogenetin binding protein 1
 6283
 0.1
chr2_31653889_31654934 0.06 Gm13424
 predicted gene 13424
 6059
 0.11
chr9_96437149_96438639 0.05 BC043934
 cDNA sequence BC043934
 244
 0.9
chr19_56721512_56724019 0.05 Adrb1
 adrenergic receptor, beta 1
 566
 0.72
chr15_85498204_85498365 0.05 7530416G11Rik
 RIKEN cDNA 7530416G11 gene
 4943
 0.21
chr17_56007063_56007232 0.04 Mpnd
 MPN domain containing
 1436
 0.18
chr11_77461921_77463199 0.04 Coro6
 coronin 6
 85
 0.96
chr4_156218489_156218788 0.04 Perm1
 PPARGC1 and ESRR induced regulator, muscle 1
 2770
 0.12
chr8_3493164_3494008 0.04 Zfp358
 zinc finger protein 358
 416
 0.72
chr12_86678734_86679882 0.04 Vash1
 vasohibin 1
 608
 0.67
chr10_99106796_99107039 0.03 Poc1b
 POC1 centriolar protein B
 119
 0.91
chr9_37527353_37531611 0.03 Esam
 endothelial cell-specific adhesion molecule
 701
 0.51
chr14_118415886_118416037 0.03 Gm5672
 predicted gene 5672
 39767
 0.12
chr7_69490962_69491246 0.03 Gm38584
 predicted gene, 38584
 303
 0.89
chr11_98294715_98295282 0.03 Gm20644
 predicted gene 20644
 9616
 0.1
chrX_151046950_151048159 0.03 Fgd1
 FYVE, RhoGEF and PH domain containing 1
 384
 0.84
chr9_77568953_77569104 0.02 Gm25250
 predicted gene, 25250
 8686
 0.15
chr1_75449862_75451492 0.02 Asic4
 acid-sensing (proton-gated) ion channel family member 4
 22
 0.95
chr7_16046118_16046491 0.02 Bicra
 BRD4 interacting chromatin remodeling complex associated protein
 1617
 0.28
chr17_47974557_47975659 0.02 Gm14871
 predicted gene 14871
 28464
 0.11
chr8_104602083_104602837 0.02 Cdh16
 cadherin 16
 10804
 0.09
chr4_133011887_133012436 0.02 Ahdc1
 AT hook, DNA binding motif, containing 1
 43
 0.97
chr4_88012278_88012656 0.01 Mllt3
 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
 20346
 0.16
chr2_58566360_58567217 0.01 Acvr1
 activin A receptor, type 1
 38
 0.91
chr4_140702801_140703286 0.01 Rcc2
 regulator of chromosome condensation 2
 1570
 0.26
chr17_66443636_66444700 0.01 Mtcl1
 microtubule crosslinking factor 1
 4201
 0.18
chr7_67952842_67953773 0.01 Igf1r
 insulin-like growth factor I receptor
 480
 0.84
chr18_68870761_68871683 0.01 Gm50260
 predicted gene, 50260
 65864
 0.12
chr2_23069108_23069648 0.01 Acbd5
 acyl-Coenzyme A binding domain containing 5
 51
 0.97
chr13_24936981_24938020 0.01 9330162012Rik
 cDNA RIKEN 9330162012 gene
 99
 0.58
chr2_93955897_93957365 0.01 Gm13889
 predicted gene 13889
 418
 0.79
chr1_172126792_172127154 0.01 Pex19
 peroxisomal biogenesis factor 19
 200
 0.88
chr15_93824709_93825690 0.00 Gm49445
 predicted gene, 49445
 161
 0.97
chr6_8509479_8509788 0.00 Glcci1
 glucocorticoid induced transcript 1
 33
 0.9

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of Glis1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0006382 adenosine to inosine editing(GO:0006382)
0.1 0.4 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.1 0.4 GO:0021637 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637)
0.1 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:2001286 regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.4 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.1 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.0 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0 0.1 GO:0033602 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of dopamine secretion(GO:0033602)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.2 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.4 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) positive regulation of renin secretion into blood stream(GO:1900135)
0.0 0.0 GO:0060486 Clara cell differentiation(GO:0060486)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0031045 dense core granule(GO:0031045)
0.0 0.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0097648 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 0.0 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.2 0.7 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.1 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels