Project

ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Glis3

Z-value: 0.56

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Transcription factors associated with Glis3

Gene Symbol	Gene ID	Gene Info
Glis3 Ensembl NCBI MGI UniProt	ENSMUSG00000052942.7	Glis3
Glis3 Ensembl NCBI MGI UniProt	ENSMUSG00000091294.1	Glis3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Glis3	chr19_28504036_28504436	36184	0.195223	0.43	6.1e-04	Click!
Glis3	chr19_28382389_28382540	56458	0.155613	-0.34	8.8e-03	Click!
Glis3	chr19_28662309_28662504	4279	0.225562	0.30	1.9e-02	Click!
Glis3	chr19_28677931_28680368	459	0.677154	-0.30	2.0e-02	Click!
Glis3	chr19_28453215_28453410	87108	0.090668	-0.28	2.8e-02	Click!

Activity of the Glis3 motif across conditions

Conditions sorted by the z-value of the Glis3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_69282071_69282727	1.33	Gm20236	predicted gene, 20236	259	0.8
chr14_69500320_69500976	1.33	Gm37094	predicted gene, 37094	258	0.81
chr7_142576289_142578620	1.20	H19	H19, imprinted maternally expressed transcript	68	0.78
chr13_24760759_24760932	1.09	Gmnn	geminin	595	0.68
chr8_84703616_84705950	1.06	Nfix	nuclear factor I/X	2933	0.13
chr10_111594457_111595800	1.04	4933440J02Rik	RIKEN cDNA 4933440J02 gene	855	0.55
chr14_69495056_69495431	0.98	Gm37094	predicted gene, 37094	5147	0.11
chr14_69276807_69277225	0.94	Gm20236	predicted gene, 20236	5124	0.1
chr1_131276506_131276860	0.89	Ikbke	inhibitor of kappaB kinase epsilon	30	0.96
chr18_75384437_75388058	0.87	Smad7	SMAD family member 7	11333	0.21
chr8_120293928_120294096	0.85	Gse1	genetic suppressor element 1, coiled-coil protein	65556	0.09
chr11_61142924_61143667	0.76	Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	630	0.65
chr5_88981527_88982249	0.74	Slc4a4	solute carrier family 4 (anion exchanger), member 4	46078	0.17
chr13_93673507_93674677	0.73	Bhmt2	betaine-homocysteine methyltransferase 2	210	0.64
chr15_44457385_44458529	0.73	Pkhd1l1	polycystic kidney and hepatic disease 1-like 1	404	0.83
chr7_142996242_142996526	0.72	Tspan32os	tetraspanin 32, opposite strand	5606	0.14
chr1_181216476_181217012	0.71	Wdr26	WD repeat domain 26	4743	0.16
chr7_16793181_16794023	0.70	Slc1a5	solute carrier family 1 (neutral amino acid transporter), member 5	425	0.73
chr4_132973841_132975368	0.70	Fgr	FGR proto-oncogene, Src family tyrosine kinase	502	0.76
chr5_119804344_119805024	0.70	1700021F13Rik	RIKEN cDNA 1700021F13 gene	2983	0.24
chr11_84820799_84820950	0.69	Mrm1	mitochondrial rRNA methyltransferase 1	1359	0.31
chr4_144892505_144894616	0.69	Dhrs3	dehydrogenase/reductase (SDR family) member 3	341	0.9
chr2_147083670_147085642	0.68	Nkx2-4	NK2 homeobox 4	789	0.65
chr8_84706606_84708426	0.68	Nfix	nuclear factor I/X	200	0.88
chr2_160603365_160603863	0.64	Gm14221	predicted gene 14221	16357	0.16
chr6_82763718_82764495	0.63	Gm17034	predicted gene 17034	176	0.93
chr4_117312229_117313344	0.62	Rnf220	ring finger protein 220	12758	0.13
chr11_18873955_18876215	0.62	8430419K02Rik	RIKEN cDNA 8430419K02 gene	776	0.61
chr8_70489289_70489965	0.60	1700020G03Rik	RIKEN cDNA 1700020G03 gene	1446	0.19
chr17_27555141_27555921	0.59	Hmga1	high mobility group AT-hook 1	966	0.25
chr2_121036316_121036674	0.59	Epb42	erythrocyte membrane protein band 4.2	186	0.9
chr1_58796177_58796388	0.59	Casp8	caspase 8	805	0.48
chr17_70850387_70852082	0.58	Tgif1	TGFB-induced factor homeobox 1	27	0.95
chr15_97054420_97055764	0.58	Slc38a4	solute carrier family 38, member 4	864	0.72
chr4_135896003_135896554	0.57	Cnr2	cannabinoid receptor 2 (macrophage)	884	0.41
chr2_146098737_146098949	0.56	Cfap61	cilia and flagella associated protein 61	51592	0.15
chr5_92126937_92127088	0.56	Gm24931	predicted gene, 24931	8729	0.12
chr5_97006383_97006630	0.56	Bmp2k	BMP2 inducible kinase	8817	0.14
chr7_19697995_19699396	0.55	Apoe	apolipoprotein E	74	0.92
chr7_44478079_44478838	0.54	5430431A17Rik	RIKEN cDNA 5430431A17 gene	4920	0.07
chr2_167671877_167672567	0.53	Gm14320	predicted gene 14320	10113	0.1
chr10_118867942_118869119	0.52	Dyrk2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	231	0.89
chr4_147969208_147969498	0.52	Nppb	natriuretic peptide type B	16435	0.09
chr2_30417827_30418146	0.52	Ptpa	protein phosphatase 2 protein activator	1684	0.2
chr6_101271319_101271470	0.52	9530086O07Rik	RIKEN cDNA 9530086O07 gene	17116	0.17
chr5_115433807_115437237	0.51	Msi1	musashi RNA-binding protein 1	24	0.93
chr6_108306863_108307717	0.49	Itpr1	inositol 1,4,5-trisphosphate receptor 1	48964	0.16
chr2_172255856_172256129	0.49	Mc3r	melanocortin 3 receptor	7500	0.18
chr1_58964778_58965097	0.49	Trak2	trafficking protein, kinesin binding 2	8492	0.15
chr9_48689387_48689590	0.49	Nnmt	nicotinamide N-methyltransferase	84335	0.09
chr14_20478404_20479012	0.48	Anxa7	annexin A7	1200	0.35
chr6_4903006_4904131	0.48	Ppp1r9a	protein phosphatase 1, regulatory subunit 9A	136	0.95
chr13_12033129_12034063	0.48	Gm47493	predicted gene, 47493	18459	0.21
chr13_109211684_109213183	0.48	Pde4d	phosphodiesterase 4D, cAMP specific	48221	0.19
chr18_32550160_32550591	0.48	Gypc	glycophorin C	9605	0.2
chr17_48300015_48301474	0.47	Treml2	triggering receptor expressed on myeloid cells-like 2	358	0.8
chr3_121891181_121891529	0.47	Gm42593	predicted gene 42593	28513	0.14
chr4_46038779_46040179	0.47	Tmod1	tropomodulin 1	270	0.92
chr8_70500810_70501374	0.46	Crlf1	cytokine receptor-like factor 1	41	0.94
chr10_103027884_103029519	0.46	Alx1	ALX homeobox 1	74	0.97
chr5_115948395_115949019	0.46	Cit	citron	2383	0.26
chr6_117900348_117901073	0.46	Hnrnpf	heterogeneous nuclear ribonucleoprotein F	370	0.73
chr14_60735927_60737075	0.46	Spata13	spermatogenesis associated 13	3595	0.24
chr17_34117887_34119117	0.45	Brd2	bromodomain containing 2	13	0.89
chr5_123040956_123041124	0.45	Morn3	MORN repeat containing 3	3328	0.11
chr13_108775293_108775893	0.44	Pde4d	phosphodiesterase 4D, cAMP specific	84573	0.1
chr15_98833260_98833542	0.44	Prkag1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	1880	0.16
chr2_153345876_153347096	0.44	2500004C02Rik	RIKEN cDNA 2500004C02 gene	413	0.6
chr10_17684003_17684189	0.44	Gm47771	predicted gene, 47771	25583	0.18
chr2_103958009_103958847	0.44	Lmo2	LIM domain only 2	433	0.78
chr4_43479376_43479653	0.43	Sit1	suppression inducing transmembrane adaptor 1	3708	0.1
chrX_7966155_7966575	0.43	Gata1	GATA binding protein 1	1545	0.2
chr8_57320946_57324000	0.43	Hand2os1	Hand2, opposite strand 1	1245	0.3
chr5_101663868_101665354	0.43	Nkx6-1	NK6 homeobox 1	385	0.86
chr3_127790290_127791036	0.43	Tifa	TRAF-interacting protein with forkhead-associated domain	8	0.96
chr2_152829459_152831273	0.43	Bcl2l1	BCL2-like 1	56	0.96
chr2_167039678_167039965	0.42	Znfx1	zinc finger, NFX1-type containing 1	3674	0.12
chr10_126979215_126980392	0.42	Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	774	0.42
chr4_140683994_140684402	0.42	Gm13025	predicted gene 13025	4445	0.14
chr3_89391665_89393338	0.42	Zbtb7b	zinc finger and BTB domain containing 7B	432	0.43
chr9_82974428_82975413	0.41	Phip	pleckstrin homology domain interacting protein	488	0.83
chr17_25087394_25087774	0.41	Ift140	intraflagellar transport 140	3087	0.14
chr5_35160468_35161280	0.40	Lrpap1	low density lipoprotein receptor-related protein associated protein 1	55108	0.11
chr3_89395650_89396522	0.40	Gm15417	predicted gene 15417	90	0.9
chr16_33751298_33751922	0.40	Heg1	heart development protein with EGF-like domains 1	1546	0.4
chr10_53435337_53435500	0.40	Gm36229	predicted gene, 36229	25536	0.12
chr7_38106410_38107383	0.40	Ccne1	cyclin E1	12	0.97
chr11_95337114_95338152	0.39	Gm11521	predicted gene 11521	225	0.77
chr13_94882690_94883964	0.39	Otp	orthopedia homeobox	727	0.7
chr18_15345788_15346105	0.39	A830021F12Rik	RIKEN cDNA A830021F12 gene	5988	0.22
chr12_80943606_80943890	0.39	Gm20337	predicted gene, 20337	1648	0.24
chr18_80707533_80708715	0.39	Nfatc1	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	49	0.97
chr3_89138382_89138543	0.39	Pklr	pyruvate kinase liver and red blood cell	1839	0.14
chr7_16783986_16784158	0.38	Slc1a5	solute carrier family 1 (neutral amino acid transporter), member 5	666	0.56
chr14_63240390_63241194	0.38	Gata4	GATA binding protein 4	4456	0.2
chr8_71475930_71476834	0.38	Dda1	DET1 and DDB1 associated 1	5971	0.08
chr7_141132681_141133038	0.38	Ptdss2	phosphatidylserine synthase 2	306	0.76
chr12_4592745_4593903	0.38	Itsn2	intersectin 2	262	0.51
chr14_31124934_31125916	0.38	Smim4	small integral membrane protein 4	3413	0.14
chr4_154022768_154023789	0.38	Smim1	small integral membrane protein 1	1045	0.34
chr8_122536554_122537967	0.38	Piezo1	piezo-type mechanosensitive ion channel component 1	14069	0.09
chr7_45018032_45018680	0.38	Rras	related RAS viral (r-ras) oncogene	273	0.72
chr2_91949326_91950727	0.38	Dgkz	diacylglycerol kinase zeta	285	0.84
chr4_133752701_133753843	0.37	Arid1a	AT rich interactive domain 1A (SWI-like)	339	0.85
chr7_29452917_29453938	0.37	Sipa1l3	signal-induced proliferation-associated 1 like 3	52025	0.1
chr4_135203168_135204139	0.37	Runx3	runt related transcription factor 3	49217	0.1
chr4_141720790_141721430	0.37	Ddi2	DNA-damage inducible protein 2	2309	0.21
chr19_16132684_16134036	0.37	Gnaq	guanine nucleotide binding protein, alpha q polypeptide	64	0.98
chr2_164441103_164441802	0.37	Sdc4	syndecan 4	1734	0.18
chr15_77904578_77904798	0.36	Txn2	thioredoxin 2	11012	0.15
chr3_138130180_138131364	0.36	Mttp	microsomal triglyceride transfer protein	605	0.65
chr10_53596930_53598102	0.36	Asf1a	anti-silencing function 1A histone chaperone	64	0.58
chr1_171442089_171442654	0.36	F11r	F11 receptor	4792	0.1
chr12_103336507_103336792	0.35	Asb2	ankyrin repeat and SOCS box-containing 2	85	0.72
chrX_159650282_159650702	0.35	Sh3kbp1	SH3-domain kinase binding protein 1	22951	0.2
chr16_20672828_20674037	0.35	Eif4g1	eukaryotic translation initiation factor 4, gamma 1	7	0.93
chr8_70493071_70496051	0.35	Crlf1	cytokine receptor-like factor 1	1200	0.25
chr19_53194082_53195694	0.35	Add3	adducin 3 (gamma)	65	0.97
chr11_95833615_95836077	0.35	Abi3	ABI gene family, member 3	1044	0.33
chr16_38362450_38363226	0.34	Popdc2	popeye domain containing 2	593	0.63
chr11_96331807_96334248	0.34	Hoxb3	homeobox B3	4965	0.08
chr6_51379176_51380008	0.34	Gm6559	predicted gene 6559	118	0.96
chr15_62121962_62122411	0.34	Pvt1	Pvt1 oncogene	23157	0.25
chr15_91369976_91370127	0.34	Slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	42166	0.18
chr2_14055011_14056286	0.34	Hacd1	3-hydroxyacyl-CoA dehydratase 1	372	0.82
chr13_45511245_45511573	0.33	Gmpr	guanosine monophosphate reductase	2431	0.33
chr16_92822245_92822888	0.33	Runx1	runt related transcription factor 1	3212	0.32
chr1_160988097_160988378	0.33	Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	1140	0.22
chr7_142658126_142659753	0.33	Igf2	insulin-like growth factor 2	550	0.47
chr5_124248924_124250266	0.33	Pitpnm2	phosphatidylinositol transfer protein, membrane-associated 2	144	0.92
chr2_130634489_130636508	0.32	Lzts3	leucine zipper, putative tumor suppressor family member 3	2597	0.15
chr3_129216664_129219042	0.32	Pitx2	paired-like homeodomain transcription factor 2	3578	0.2
chrX_12001809_12002609	0.32	Gm14512	predicted gene 14512	17741	0.23
chr11_117782674_117783995	0.32	Tmc8	transmembrane channel-like gene family 8	676	0.39
chr18_65092314_65092688	0.32	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	9447	0.25
chr11_78303369_78303520	0.32	Spag5	sperm associated antigen 5	1789	0.16
chr8_107095938_107096820	0.32	Terf2	telomeric repeat binding factor 2	135	0.67
chr16_22881087_22881238	0.32	Ahsg	alpha-2-HS-glycoprotein	10115	0.11
chr14_76532606_76533942	0.31	E130202H07Rik	RIKEN cDNA E130202H07 gene	6658	0.2
chr10_93833520_93834579	0.31	Usp44	ubiquitin specific peptidase 44	231	0.91
chr9_64533785_64534038	0.31	Megf11	multiple EGF-like-domains 11	12988	0.25
chr19_55746711_55749175	0.31	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	5098	0.32
chr4_124605630_124606127	0.31	4933407E24Rik	RIKEN cDNA 4933407E24 gene	36688	0.11
chr7_47357377_47358685	0.31	Mrgpra1	MAS-related GPR, member A1	3791	0.17
chr9_107288899_107290229	0.31	Mapkapk3	mitogen-activated protein kinase-activated protein kinase 3	183	0.89
chr13_109632540_109633637	0.31	Pde4d	phosphodiesterase 4D, cAMP specific	308	0.95
chr11_95896737_95897369	0.31	B4galnt2	beta-1,4-N-acetyl-galactosaminyl transferase 2	17838	0.09
chr5_29467659_29468760	0.31	Mnx1	motor neuron and pancreas homeobox 1	10261	0.16
chr14_55105801_55106847	0.30	Ap1g2	adaptor protein complex AP-1, gamma 2 subunit	57	0.94
chr1_135836765_135837624	0.30	Tnnt2	troponin T2, cardiac	781	0.54
chr3_69588620_69588951	0.30	B3galnt1	UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1	10175	0.18
chr9_66157901_66159171	0.30	Dapk2	death-associated protein kinase 2	301	0.9
chr15_77837622_77838284	0.30	Gm22107	predicted gene, 22107	2803	0.2
chr17_84185673_84188034	0.30	Zfp36l2	zinc finger protein 36, C3H type-like 2	1094	0.34
chr7_127090806_127091953	0.30	AI467606	expressed sequence AI467606	20	0.93
chr11_95009478_95010181	0.30	Samd14	sterile alpha motif domain containing 14	50	0.95
chr3_115758693_115759280	0.30	Gm9889	predicted gene 9889	43836	0.13
chr17_56728100_56728600	0.30	Fut4-ps1	fucosyltransferase 4, pseudogene 1	5878	0.1
chr16_23102639_23103369	0.30	Eif4a2	eukaryotic translation initiation factor 4A2	4440	0.07
chr4_63152318_63152930	0.30	Ambp	alpha 1 microglobulin/bikunin precursor	1549	0.36
chr4_130913313_130914133	0.30	Laptm5	lysosomal-associated protein transmembrane 5	365	0.85
chr1_21963069_21963530	0.30	Kcnq5	potassium voltage-gated channel, subfamily Q, member 5	1357	0.56
chr7_133114831_133116529	0.30	Ctbp2	C-terminal binding protein 2	2981	0.2
chr1_74027276_74028287	0.29	Tns1	tensin 1	9352	0.23
chr1_136139800_136140905	0.29	Kif21b	kinesin family member 21B	8898	0.11
chr4_128805343_128806839	0.29	Zfp362	zinc finger protein 362	46	0.97
chr1_171189020_171190029	0.29	Pcp4l1	Purkinje cell protein 4-like 1	6744	0.09
chr9_111055888_111057545	0.29	Ccrl2	chemokine (C-C motif) receptor-like 2	530	0.62
chr5_122101950_122102247	0.29	Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	301	0.86
chr12_109452854_109454456	0.29	Dlk1	delta like non-canonical Notch ligand 1	0	0.96
chr2_164772892_164773805	0.29	Ube2c	ubiquitin-conjugating enzyme E2C	3445	0.09
chr7_45797605_45798943	0.29	Lmtk3	lemur tyrosine kinase 3	10526	0.07
chr14_54971177_54971539	0.29	Gm29015	predicted gene 29015	1671	0.12
chr9_21961394_21962913	0.29	Epor	erythropoietin receptor	411	0.68
chr11_33202043_33204837	0.29	Tlx3	T cell leukemia, homeobox 3	149	0.86
chr1_172501767_172503923	0.29	Tagln2	transgelin 2	1593	0.22
chr11_94242616_94243821	0.29	Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	511	0.76
chr2_181081653_181082036	0.29	Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	13577	0.13
chr3_127123282_127124895	0.29	Ank2	ankyrin 2, brain	774	0.59
chr6_52174920_52176658	0.29	Hoxaas3	Hoxa cluster antisense RNA 3	554	0.41
chr1_85735264_85735792	0.29	A630001G21Rik	RIKEN cDNA A630001G21 gene	1026	0.4
chr18_11058575_11059292	0.29	Gata6	GATA binding protein 6	114	0.97
chr3_95673620_95674691	0.28	Adamtsl4	ADAMTS-like 4	2996	0.14
chr12_103656514_103657055	0.28	Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	318	0.81
chr9_58656515_58657338	0.28	Rec114	REC114 meiotic recombination protein	2366	0.27
chr4_135152193_135153995	0.28	Runx3	runt related transcription factor 3	66	0.97
chr18_80712423_80713681	0.28	Nfatc1	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	6	0.98
chr16_17560824_17562372	0.28	P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	287	0.52
chr6_49218211_49218700	0.28	Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	3498	0.19
chr1_133245733_133247220	0.28	Plekha6	pleckstrin homology domain containing, family A member 6	370	0.84
chr7_132812969_132814132	0.28	Fam53b	family with sequence similarity 53, member B	22	0.97
chr5_119834833_119836185	0.28	Tbx5	T-box 5	646	0.68
chr4_134766990_134768275	0.28	Ldlrap1	low density lipoprotein receptor adaptor protein 1	392	0.86
chr1_131971821_131972623	0.28	Slc45a3	solute carrier family 45, member 3	1613	0.26
chr12_110971721_110972289	0.28	Ankrd9	ankyrin repeat domain 9	6250	0.12
chr5_137749206_137749783	0.28	Tsc22d4	TSC22 domain family, member 4	1688	0.19
chr14_75837036_75838166	0.28	Gm48931	predicted gene, 48931	3885	0.16
chr5_144645368_144645519	0.28	Gm6272	predicted pseudogene 6272	78354	0.08
chr19_53325039_53326410	0.28	Gm30541	predicted gene, 30541	1	0.97
chr3_57425387_57425767	0.28	Tm4sf4	transmembrane 4 superfamily member 4	263	0.93

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Glis3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.2	0.6	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.2	0.5	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1	0.4	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1	0.4	GO:0071688	skeletal muscle myosin thick filament assembly(GO:0030241) striated muscle myosin thick filament assembly(GO:0071688)
0.1	1.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1	0.9	GO:2000653	regulation of genetic imprinting(GO:2000653)
0.1	0.4	GO:0052490	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.1	0.4	GO:0051891	positive regulation of cardioblast differentiation(GO:0051891)
0.1	0.1	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.1	0.7	GO:0015825	L-serine transport(GO:0015825)
0.1	0.6	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.1	0.4	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1	0.5	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.1	0.4	GO:0061325	cell proliferation involved in outflow tract morphogenesis(GO:0061325)
0.1	0.3	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.3	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1	0.6	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.1	0.3	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.1	0.3	GO:0051684	maintenance of Golgi location(GO:0051684)
0.1	0.3	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.1	0.3	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.1	0.4	GO:0010587	miRNA catabolic process(GO:0010587)
0.1	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.1	0.2	GO:1905005	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1	0.2	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.1	0.2	GO:0002884	negative regulation of hypersensitivity(GO:0002884)
0.1	0.5	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.1	0.2	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.1	0.2	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1	0.2	GO:0060847	endothelial cell fate specification(GO:0060847)
0.1	0.5	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.1	0.3	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.1	0.4	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1	0.8	GO:0043249	erythrocyte maturation(GO:0043249)
0.1	0.3	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.1	0.1	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.1	0.2	GO:0031627	telomeric loop formation(GO:0031627)
0.1	0.2	GO:0015766	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1	0.8	GO:0033275	actin-myosin filament sliding(GO:0033275)
0.1	0.1	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.2	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1	0.2	GO:0034633	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.1	0.5	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1	0.1	GO:0021538	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1	0.2	GO:0060931	sinoatrial node cell development(GO:0060931)
0.1	0.2	GO:0035973	aggrephagy(GO:0035973)
0.1	0.2	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.1	0.2	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1	0.1	GO:0072199	mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199)
0.1	0.3	GO:0009446	putrescine biosynthetic process(GO:0009446)
0.1	0.2	GO:1902416	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.1	0.1	GO:0033686	positive regulation of luteinizing hormone secretion(GO:0033686)
0.1	0.2	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.1	0.2	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.1	0.2	GO:0001555	oocyte growth(GO:0001555)
0.1	0.4	GO:0045634	regulation of melanocyte differentiation(GO:0045634)
0.1	0.2	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.1	0.3	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1	0.2	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
0.1	0.2	GO:0071673	positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.1	0.2	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.1	0.1	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1	0.2	GO:0061072	iris morphogenesis(GO:0061072)
0.1	0.1	GO:2000870	regulation of progesterone secretion(GO:2000870)
0.1	0.2	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.1	0.1	GO:0035799	ureter maturation(GO:0035799)
0.1	0.2	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.2	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1	0.2	GO:0060264	regulation of respiratory burst involved in inflammatory response(GO:0060264)
0.1	0.2	GO:0002930	trabecular meshwork development(GO:0002930)
0.1	0.1	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0	0.3	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.4	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.1	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.0	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.7	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.3	GO:0044351	macropinocytosis(GO:0044351)
0.0	0.3	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.2	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.3	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.2	GO:0007290	spermatid nucleus elongation(GO:0007290)
0.0	0.1	GO:1900222	negative regulation of beta-amyloid clearance(GO:1900222)
0.0	0.1	GO:0002441	histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0	0.2	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.0	0.3	GO:1901223	negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0010725	regulation of primitive erythrocyte differentiation(GO:0010725)
0.0	0.2	GO:0071107	response to parathyroid hormone(GO:0071107)
0.0	0.1	GO:0097114	NMDA glutamate receptor clustering(GO:0097114)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.6	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.9	GO:0034340	response to type I interferon(GO:0034340)
0.0	0.2	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.0	0.1	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.0	0.1	GO:0010993	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0	0.2	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.2	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.2	GO:0002576	platelet degranulation(GO:0002576)
0.0	0.2	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0060399	positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0	0.1	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.3	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:0003176	aortic valve development(GO:0003176) aortic valve morphogenesis(GO:0003180)
0.0	0.3	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0060903	positive regulation of meiosis I(GO:0060903)
0.0	0.1	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.3	GO:0021979	hypothalamus cell differentiation(GO:0021979)
0.0	0.1	GO:0032349	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0	0.1	GO:0061643	chemorepulsion of axon(GO:0061643)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.0	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.0	0.2	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.2	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.2	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.0	0.2	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:1900135	positive regulation of renin secretion into blood stream(GO:1900135)
0.0	0.2	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.0	GO:0050904	diapedesis(GO:0050904)
0.0	0.1	GO:0072282	metanephric nephron tubule morphogenesis(GO:0072282)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0038027	apolipoprotein A-I-mediated signaling pathway(GO:0038027)
0.0	0.1	GO:1904017	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.3	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.2	GO:0035459	cargo loading into vesicle(GO:0035459)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0	0.1	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.1	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.2	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0	0.2	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.1	GO:0033184	positive regulation of histone ubiquitination(GO:0033184)
0.0	0.1	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.1	GO:0021747	cochlear nucleus development(GO:0021747)
0.0	0.2	GO:2001185	regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.0	0.1	GO:0070346	positive regulation of fat cell proliferation(GO:0070346)
0.0	0.3	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.2	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0036302	atrioventricular canal development(GO:0036302)
0.0	0.2	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.2	GO:0061032	visceral serous pericardium development(GO:0061032)
0.0	0.3	GO:0032367	intracellular cholesterol transport(GO:0032367)
0.0	0.1	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.0	GO:0097360	chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0	0.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.0	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.3	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0	0.2	GO:0035330	regulation of hippo signaling(GO:0035330)
0.0	0.1	GO:0002540	leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.2	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.0	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	0.6	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.2	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.0	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.0	GO:0061083	regulation of protein refolding(GO:0061083)
0.0	0.0	GO:0035983	response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.0	0.0	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0060214	endocardium formation(GO:0060214)
0.0	0.0	GO:0090306	spindle assembly involved in meiosis(GO:0090306)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.2	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.2	GO:2000786	positive regulation of autophagosome assembly(GO:2000786)
0.0	0.0	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.0	GO:0001810	regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068)
0.0	0.2	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.0	0.1	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0060128	corticotropin hormone secreting cell differentiation(GO:0060128)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.3	GO:0006144	purine nucleobase metabolic process(GO:0006144)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.0	GO:0072193	ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.1	GO:0035562	negative regulation of chromatin binding(GO:0035562)
0.0	0.1	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.0	GO:2000630	positive regulation of miRNA metabolic process(GO:2000630)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.2	GO:0038092	nodal signaling pathway(GO:0038092)
0.0	0.8	GO:0008156	negative regulation of DNA replication(GO:0008156)
0.0	0.0	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:0070535	histone H2A K63-linked ubiquitination(GO:0070535)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.0	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.1	GO:0072584	caveolin-mediated endocytosis(GO:0072584)
0.0	0.0	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.4	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0	0.3	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0	0.0	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.2	GO:0042761	very long-chain fatty acid biosynthetic process(GO:0042761)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0048880	sensory system development(GO:0048880)
0.0	0.3	GO:0031571	mitotic G1 DNA damage checkpoint(GO:0031571)
0.0	0.2	GO:0009992	cellular water homeostasis(GO:0009992)
0.0	0.0	GO:0032351	negative regulation of hormone metabolic process(GO:0032351)
0.0	0.2	GO:0032332	positive regulation of chondrocyte differentiation(GO:0032332)
0.0	0.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.1	GO:0002432	granuloma formation(GO:0002432)
0.0	0.2	GO:0071801	regulation of podosome assembly(GO:0071801)
0.0	0.5	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.0	GO:0014891	skeletal muscle atrophy(GO:0014732) striated muscle atrophy(GO:0014891)
0.0	0.2	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.2	GO:0043949	regulation of cAMP-mediated signaling(GO:0043949)
0.0	0.1	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.1	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.2	GO:0071545	inositol phosphate catabolic process(GO:0071545)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.0	GO:0071898	regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0	0.0	GO:1904354	negative regulation of telomere capping(GO:1904354)
0.0	0.0	GO:0060558	regulation of calcidiol 1-monooxygenase activity(GO:0060558)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.0	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0	0.3	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.1	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0006742	NADP catabolic process(GO:0006742)
0.0	0.1	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.1	GO:0033601	positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0	0.0	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.0	GO:1903333	negative regulation of protein folding(GO:1903333)
0.0	0.0	GO:0055015	ventricular cardiac muscle cell development(GO:0055015)
0.0	0.1	GO:1900165	negative regulation of interleukin-6 secretion(GO:1900165)
0.0	0.1	GO:0086073	cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.1	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.0	0.0	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.5	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.0	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	0.0	GO:0042364	water-soluble vitamin biosynthetic process(GO:0042364)
0.0	0.1	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.2	GO:1900153	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.0	0.2	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0	0.3	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.3	GO:0008211	glucocorticoid metabolic process(GO:0008211)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0018158	protein oxidation(GO:0018158)
0.0	0.0	GO:2001055	positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.0	GO:1903753	negative regulation of p38MAPK cascade(GO:1903753)
0.0	0.1	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0	0.0	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.1	GO:0032324	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0042421	norepinephrine biosynthetic process(GO:0042421)
0.0	0.0	GO:0006524	alanine catabolic process(GO:0006524) pyruvate family amino acid catabolic process(GO:0009080)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0	0.0	GO:0046125	pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0	0.1	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.1	GO:2000773	negative regulation of cellular senescence(GO:2000773)
0.0	0.1	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.1	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.0	0.0	GO:0048619	embryonic hindgut morphogenesis(GO:0048619)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0090258	negative regulation of mitochondrial fission(GO:0090258)
0.0	0.0	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.1	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.0	GO:0007494	midgut development(GO:0007494)
0.0	0.3	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.2	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.0	0.2	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.1	GO:0014898	muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.0	GO:0010535	positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0	0.1	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.0	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0	0.0	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0	0.0	GO:0036166	phenotypic switching(GO:0036166)
0.0	0.0	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0	0.2	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.0	GO:0010873	positive regulation of cholesterol esterification(GO:0010873)
0.0	0.0	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.0	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0	0.1	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0014807	regulation of somitogenesis(GO:0014807)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.2	GO:0033198	response to ATP(GO:0033198)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0	0.0	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0	0.0	GO:0090170	regulation of Golgi inheritance(GO:0090170)
0.0	0.0	GO:1903772	regulation of viral budding via host ESCRT complex(GO:1903772)
0.0	0.0	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.0	GO:0051697	protein delipidation(GO:0051697)
0.0	0.2	GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239)
0.0	0.1	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0034380	high-density lipoprotein particle assembly(GO:0034380)
0.0	0.0	GO:0016539	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.2	0.5	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.1	0.5	GO:0044326	dendritic spine neck(GO:0044326)
0.1	0.3	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.3	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.1	0.2	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	0.3	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	0.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	0.3	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1	0.2	GO:0042583	chromaffin granule(GO:0042583)
0.1	0.3	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.5	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.2	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.3	GO:0005861	troponin complex(GO:0005861)
0.0	0.2	GO:0001651	dense fibrillar component(GO:0001651)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	1.5	GO:0005844	polysome(GO:0005844)
0.0	0.3	GO:0005859	muscle myosin complex(GO:0005859)
0.0	0.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.5	GO:0005865	striated muscle thin filament(GO:0005865)
0.0	0.4	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.3	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.2	GO:0001940	male pronucleus(GO:0001940)
0.0	0.4	GO:0001741	XY body(GO:0001741)
0.0	0.3	GO:0071564	npBAF complex(GO:0071564)
0.0	1.6	GO:0016605	PML body(GO:0016605)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	0.2	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.6	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.3	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.0	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.2	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.0	GO:0005879	axonemal microtubule(GO:0005879)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.5	GO:0030118	clathrin coat(GO:0030118)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.1	GO:0097470	ribbon synapse(GO:0097470)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0	1.3	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.1	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.1	GO:0070876	SOSS complex(GO:0070876)
0.0	0.1	GO:0005775	vacuolar lumen(GO:0005775)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	4.0	GO:0005667	transcription factor complex(GO:0005667)
0.0	0.0	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.2	GO:0043196	varicosity(GO:0043196)
0.0	0.0	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.0	GO:0035363	histone locus body(GO:0035363)
0.0	0.1	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0008384	IkappaB kinase activity(GO:0008384)
0.2	0.6	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.2	0.8	GO:0046848	hydroxyapatite binding(GO:0046848)
0.2	0.7	GO:0001224	RNA polymerase II transcription cofactor binding(GO:0001224)
0.2	0.5	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.2	0.6	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.1	0.4	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.1	0.4	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1	0.4	GO:0051434	BH3 domain binding(GO:0051434)
0.1	0.6	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.1	0.3	GO:0035877	death effector domain binding(GO:0035877)
0.1	0.3	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.7	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.2	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.1	0.2	GO:0015154	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1	0.3	GO:1990715	mRNA CDS binding(GO:1990715)
0.1	0.4	GO:0001727	lipid kinase activity(GO:0001727)
0.1	0.6	GO:0070410	co-SMAD binding(GO:0070410)
0.1	0.5	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1	0.3	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1	0.7	GO:0005523	tropomyosin binding(GO:0005523)
0.1	0.4	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.1	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1	0.8	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.1	0.2	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1	0.2	GO:1990188	euchromatin binding(GO:1990188)
0.1	0.2	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.3	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.2	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:0046538	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.2	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.1	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.1	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0	0.5	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.2	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.0	0.2	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.1	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.0	0.1	GO:0019862	IgA binding(GO:0019862)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.2	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.2	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0015216	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.1	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.2	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.3	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.3	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	1.6	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.2	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.5	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.3	GO:0005542	folic acid binding(GO:0005542)
0.0	0.2	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.3	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0045322	unmethylated CpG binding(GO:0045322)
0.0	0.6	GO:0004119	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.3	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.3	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.1	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.4	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0050145	nucleoside phosphate kinase activity(GO:0050145)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0052832	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0004112	cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0	0.1	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.0	GO:0034617	tetrahydrobiopterin binding(GO:0034617)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.3	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.4	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.0	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	0.1	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.0	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.7	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	0.5	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0	0.0	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.0	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.7	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.2	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0016649	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	1.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0097642	calcitonin family receptor activity(GO:0097642)
0.0	0.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.2	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.0	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.1	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.0	0.1	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:0016755	transferase activity, transferring amino-acyl groups(GO:0016755)
0.0	0.0	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.0	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.4	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.0	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.0	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.0	GO:0004854	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0	0.2	GO:0005537	mannose binding(GO:0005537)
0.0	0.0	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.3	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
1.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.3	PID EPO PATHWAY	EPO signaling pathway
0.9	PID ALK1 PATHWAY	ALK1 signaling events
0.0	PID S1P S1P2 PATHWAY	S1P2 pathway
1.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.7	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
1.4	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
1.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.5	PID P53 REGULATION PATHWAY	p53 pathway
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.3	PID RHOA PATHWAY	RhoA signaling pathway
0.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.2	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	PID ATM PATHWAY	ATM pathway
0.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.1	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.1	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.1	0.9	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1	1.0	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	1.4	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1	0.8	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	0.2	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	1.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.5	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.2	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.4	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.7	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	1.0	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.4	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.3	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.4	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.0	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.3	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.0	0.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.2	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0	0.2	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.0	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.2	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.1	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.0	0.2	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.1	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.2	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.2	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.0	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.1	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)