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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development
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Results for Hif1a

Z-value: 0.54

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Transcription factors associated with Hif1a

Gene Symbol Gene ID Gene Info
Hif1a
ENSMUSG00000021109.7 hypoxia inducible factor 1, alpha subunit

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_73901338_73901489Hif1a380.973379-0.255.2e-02Click!
chr12_73916045_73916196Hif1a82160.1580130.246.9e-02Click!
chr12_73912214_73912365Hif1a43850.1857840.152.5e-01Click!
chr12_73913244_73913533Hif1a54840.1734650.114.1e-01Click!
chr12_73902065_73902216Hif1a7650.6190390.114.1e-01Click!

Activity of the Hif1a motif across conditions

Conditions sorted by the z-value of the Hif1a motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_118568846_118570341 1.29 Rbfox3
 RNA binding protein, fox-1 homolog (C. elegans) 3
 317
 0.91
chr13_54765549_54766801 1.09 Sncb
 synuclein, beta
 78
 0.95
chr7_44336079_44337576 0.96 Shank1
 SH3 and multiple ankyrin repeat domains 1
 811
 0.34
chr2_152081612_152083149 0.95 Scrt2
 scratch family zinc finger 2
 851
 0.52
chrX_110814269_110815716 0.88 Pou3f4
 POU domain, class 3, transcription factor 4
 712
 0.71
chr7_121391567_121393161 0.78 Hs3st2
 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
 74
 0.93
chr1_42697532_42698715 0.77 Pou3f3
 POU domain, class 3, transcription factor 3
 2355
 0.2
chr4_138394975_138396803 0.75 Fam43b
 family with sequence similarity 43, member B
 639
 0.41
chr7_87584098_87584781 0.71 Grm5
 glutamate receptor, metabotropic 5
 41
 0.99
chr11_3331744_3332343 0.70 Pik3ip1
 phosphoinositide-3-kinase interacting protein 1
 29
 0.93
chr14_3571642_3572719 0.67 Gm3005
 predicted gene 3005
 157
 0.94
chr19_44674504_44675304 0.66 Gm26644
 predicted gene, 26644
 20371
 0.15
chr2_22895605_22896237 0.66 Pdss1
 prenyl (solanesyl) diphosphate synthase, subunit 1
 127
 0.58
chr13_116302578_116304501 0.65 Isl1
 ISL1 transcription factor, LIM/homeodomain
 188
 0.96
chr14_3809696_3810741 0.65 Gm3002
 predicted gene 3002
 144
 0.94
chr14_5812168_5813063 0.64 Gm3383
 predicted gene 3383
 4633
 0.14
chr14_4018473_4019517 0.63 Gm5796
 predicted gene 5796
 4946
 0.14
chr1_91344585_91345841 0.63 Klhl30
 kelch-like 30
 5803
 0.11
chr14_19584548_19585598 0.63 Gm2237
 predicted gene 2237
 62
 0.95
chr8_119394920_119395525 0.62 Mlycd
 malonyl-CoA decarboxylase
 324
 0.87
chr19_5695606_5696740 0.62 Map3k11
 mitogen-activated protein kinase kinase kinase 11
 3278
 0.08
chr14_4726384_4727541 0.62 Gm3252
 predicted gene 3252
 187
 0.91
chr14_6756399_6757462 0.61 Gm3636
 predicted gene 3636
 14598
 0.14
chr14_4498814_4499998 0.60 Gm3173
 predicted gene 3173
 15352
 0.11
chr14_6286765_6287923 0.60 Gm3411
 predicted gene 3411
 94
 0.95
chr7_49911362_49912424 0.60 Slc6a5
 solute carrier family 6 (neurotransmitter transporter, glycine), member 5
 193
 0.96
chr14_3412245_3413254 0.58 Gm10409
 predicted gene 10409
 135
 0.93
chr15_80287040_80287449 0.57 Cacna1i
 calcium channel, voltage-dependent, alpha 1I subunit
 6
 0.97
chr14_5459633_5460571 0.57 Gm3194
 predicted gene 3194
 4635
 0.14
chr9_87015230_87016430 0.57 Ripply2
 ripply transcriptional repressor 2
 194
 0.94
chr14_7026733_7027810 0.56 Gm10406
 predicted gene 10406
 178
 0.93
chr4_22486897_22487389 0.56 Pou3f2
 POU domain, class 3, transcription factor 2
 1223
 0.42
chr9_45430098_45431532 0.56 4833428L15Rik
 RIKEN cDNA 4833428L15 gene
 417
 0.52
chr10_81272581_81272732 0.56 Apba3
 amyloid beta (A4) precursor protein-binding, family A, member 3
 38
 0.9
chr14_6426291_6427481 0.55 Lamtor3-ps
 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, pseudogene
 14404
 0.14
chr2_128758874_128759147 0.54 Gm14011
 predicted gene 14011
 5305
 0.16
chr14_7173946_7175014 0.54 Gm3512
 predicted gene 3512
 53
 0.97
chr14_3332235_3333462 0.54 Gm2956
 predicted gene 2956
 221
 0.91
chr14_7487792_7489005 0.52 Gm3752
 predicted gene 3752
 4636
 0.16
chr14_4182195_4183376 0.52 Gm2974
 predicted gene 2974
 209
 0.91
chrX_136666183_136667703 0.52 Tceal3
 transcription elongation factor A (SII)-like 3
 332
 0.84
chr14_7657902_7658985 0.51 Gm10128
 predicted gene 10128
 14471
 0.16
chr14_5501278_5502453 0.50 Gm3488
 predicted gene, 3488
 191
 0.9
chr7_46348707_46349190 0.50 1700025L06Rik
 RIKEN cDNA 1700025L06 gene
 106
 0.96
chr4_107823086_107824019 0.49 Lrp8
 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
 391
 0.53
chr3_73053153_73054210 0.48 Slitrk3
 SLIT and NTRK-like family, member 3
 3262
 0.23
chr2_164967685_164969910 0.47 Slc12a5
 solute carrier family 12, member 5
 516
 0.7
chr14_5148637_5149909 0.46 Gm3317
 predicted gene 3317
 15262
 0.11
chr17_51461105_51461697 0.45 Gm46574
 predicted gene, 46574
 23320
 0.19
chr7_98193340_98194780 0.45 B3gnt6
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
 5421
 0.16
chr14_7104815_7105770 0.45 Gm3696
 predicted gene 3696
 4671
 0.16
chr16_8424071_8425359 0.45 Tmem114
 transmembrane protein 114
 421
 0.83
chr14_6107781_6108962 0.45 Gm3468
 predicted gene 3468
 294
 0.84
chr7_137318563_137320070 0.44 Ebf3
 early B cell factor 3
 4871
 0.21
chr14_4334314_4335468 0.44 2610042L04Rik
 RIKEN cDNA 2610042L04 gene
 128
 0.95
chr14_3651660_3652927 0.42 Gm3020
 predicted gene 3020
 263
 0.87
chr7_79504311_79505700 0.42 Mir9-3
 microRNA 9-3
 259
 0.82
chr1_177446374_177448525 0.41 Zbtb18
 zinc finger and BTB domain containing 18
 1628
 0.31
chr5_37241461_37244349 0.40 Crmp1
 collapsin response mediator protein 1
 171
 0.95
chr11_69800783_69801791 0.40 Fgf11
 fibroblast growth factor 11
 429
 0.56
chr6_48628821_48630012 0.39 AI854703
 expressed sequence AI854703
 1481
 0.18
chr14_65423052_65425451 0.39 Pnoc
 prepronociceptin
 909
 0.6
chr2_156613822_156614400 0.38 Dlgap4
 DLG associated protein 4
 406
 0.56
chr11_47988311_47989415 0.38 Sgcd
 sarcoglycan, delta (dystrophin-associated glycoprotein)
 106
 0.98
chr16_43979809_43980249 0.38 Zdhhc23
 zinc finger, DHHC domain containing 23
 238
 0.91
chr13_39653133_39653284 0.38 Gm32243
 predicted gene, 32243
 5961
 0.22
chr2_156614815_156615561 0.38 Gm14174
 predicted gene 14174
 260
 0.82
chr11_82388570_82389922 0.37 Tmem132e
 transmembrane protein 132E
 123
 0.96
chr2_25318080_25319601 0.37 Grin1
 glutamate receptor, ionotropic, NMDA1 (zeta 1)
 255
 0.77
chr14_4855192_4856263 0.37 Gm3264
 predicted gene 3264
 151
 0.94
chr7_44985301_44986386 0.37 Prmt1
 protein arginine N-methyltransferase 1
 473
 0.48
chr5_139546076_139547826 0.37 Uncx
 UNC homeobox
 3053
 0.23
chr18_65430358_65430843 0.36 Malt1
 MALT1 paracaspase
 338
 0.82
chr3_144396551_144396705 0.36 Gm5857
 predicted gene 5857
 31044
 0.17
chr14_32462734_32463939 0.36 Chat
 choline acetyltransferase
 1294
 0.28
chr8_41054476_41055299 0.36 Mtus1
 mitochondrial tumor suppressor 1
 93
 0.95
chr5_122950311_122951097 0.35 Kdm2b
 lysine (K)-specific demethylase 2B
 1286
 0.34
chr11_68384940_68385629 0.35 Ntn1
 netrin 1
 1542
 0.44
chr12_112928791_112929397 0.35 Jag2
 jagged 2
 646
 0.51
chr11_11113816_11114856 0.34 Vwc2
 von Willebrand factor C domain containing 2
 113
 0.98
chr2_70561988_70564432 0.34 Gad1os
 glutamate decarboxylase 1, opposite strand
 147
 0.61
chr7_25180336_25182324 0.34 Pou2f2
 POU domain, class 2, transcription factor 2
 1604
 0.22
chr5_120409346_120410480 0.34 Lhx5
 LIM homeobox protein 5
 21786
 0.12
chr8_29218667_29220085 0.34 Unc5d
 unc-5 netrin receptor D
 51
 0.98
chr10_84754760_84756248 0.34 Rfx4
 regulatory factor X, 4 (influences HLA class II expression)
 558
 0.8
chr5_110652833_110653341 0.34 Noc4l
 NOC4 like
 172
 0.69
chr14_6889307_6890296 0.33 Gm3667
 predicted gene 3667
 161
 0.95
chr1_17097801_17097987 0.33 Jph1
 junctophilin 1
 5
 0.98
chr9_37433470_37434351 0.33 Robo3
 roundabout guidance receptor 3
 664
 0.59
chr18_42394146_42396205 0.33 Pou4f3
 POU domain, class 4, transcription factor 3
 100
 0.97
chr9_90162957_90164072 0.33 Adamts7
 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7
 288
 0.88
chr13_95989973_95990124 0.32 Sv2c
 synaptic vesicle glycoprotein 2c
 178
 0.96
chr4_82513112_82513640 0.32 Gm11266
 predicted gene 11266
 5360
 0.22
chr11_119190727_119190895 0.32 Gm11753
 predicted gene 11753
 6295
 0.13
chr7_99182821_99183252 0.32 Dgat2
 diacylglycerol O-acyltransferase 2
 317
 0.84
chr4_42917314_42917764 0.31 Phf24
 PHD finger protein 24
 205
 0.91
chr7_78989959_78991095 0.31 Gm26633
 predicted gene, 26633
 62796
 0.08
chr3_54915029_54916379 0.31 Sertm1
 serine rich and transmembrane domain containing 1
 183
 0.96
chr9_91363965_91365514 0.31 Zic1
 zinc finger protein of the cerebellum 1
 1029
 0.35
chr2_6322398_6322669 0.31 Usp6nl
 USP6 N-terminal like
 134
 0.86
chr3_139205663_139206386 0.31 Stpg2
 sperm tail PG rich repeat containing 2
 131
 0.98
chr13_52529695_52530820 0.31 Diras2
 DIRAS family, GTP-binding RAS-like 2
 1022
 0.66
chr9_72925072_72926177 0.31 Pygo1
 pygopus 1
 21
 0.95
chrX_166238673_166239964 0.31 Gpm6b
 glycoprotein m6b
 346
 0.9
chr1_157243489_157244692 0.30 Rasal2
 RAS protein activator like 2
 400
 0.88
chr10_78746927_78747974 0.30 Gm30400
 predicted gene, 30400
 291
 0.84
chr15_75746536_75747326 0.29 Mafa
 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
 1297
 0.33
chr5_111419755_111420664 0.29 Mn1
 meningioma 1
 2767
 0.22
chr2_28195247_28196182 0.29 Olfm1
 olfactomedin 1
 2621
 0.32
chr10_80226705_80227856 0.29 Pwwp3a
 PWWP domain containing 3A, DNA repair factor
 529
 0.58
chr7_99468579_99468981 0.29 Klhl35
 kelch-like 35
 183
 0.9
chr7_46179165_46180456 0.29 Abcc8
 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
 176
 0.92
chr2_25567077_25567419 0.28 Mamdc4
 MAM domain containing 4
 1867
 0.13
chr7_126692598_126692845 0.28 Bola2
 bolA-like 2 (E. coli)
 2680
 0.09
chr4_62499250_62499401 0.28 Hdhd3
 haloacid dehalogenase-like hydrolase domain containing 3
 2951
 0.15
chr1_34579671_34580338 0.28 1700101I19Rik
 RIKEN cDNA 1700101I19 gene
 293
 0.5
chr7_112225522_112225723 0.28 Mical2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 234
 0.96
chr7_141221857_141222428 0.28 Mir210
 microRNA 210
 649
 0.44
chr10_41070697_41071486 0.28 Gpr6
 G protein-coupled receptor 6
 1194
 0.41
chr18_40256495_40257230 0.28 Kctd16
 potassium channel tetramerisation domain containing 16
 100
 0.96
chr13_18948071_18948332 0.27 Amph
 amphiphysin
 4
 0.97
chr12_112779696_112780559 0.27 Ahnak2
 AHNAK nucleoprotein 2
 884
 0.42
chr1_180894021_180894978 0.27 Lefty2
 left-right determination factor 2
 41
 0.95
chr5_36529349_36530504 0.27 Tbc1d14
 TBC1 domain family, member 14
 581
 0.71
chr9_53705377_53706662 0.26 Rab39
 RAB39, member RAS oncogene family
 213
 0.91
chr19_45228695_45230660 0.26 Lbx1
 ladybird homeobox 1
 6135
 0.2
chr5_73006697_73007924 0.25 Slc10a4
 solute carrier family 10 (sodium/bile acid cotransporter family), member 4
 407
 0.74
chr7_5052519_5053499 0.25 Zfp580
 zinc finger protein 580
 1020
 0.21
chr15_76517568_76519917 0.25 Scrt1
 scratch family zinc finger 1
 3160
 0.09
chr6_128842519_128843166 0.25 Gm44066
 predicted gene, 44066
 329
 0.76
chr4_134747576_134747727 0.25 Ldlrap1
 low density lipoprotein receptor adaptor protein 1
 2456
 0.3
chr1_181352204_181352681 0.25 Cnih3
 cornichon family AMPA receptor auxiliary protein 3
 186
 0.94
chr6_39256378_39257582 0.24 Gm26008
 predicted gene, 26008
 8962
 0.16
chr14_70079421_70080436 0.24 Egr3
 early growth response 3
 1189
 0.41
chr6_29272372_29272690 0.24 Hilpda
 hypoxia inducible lipid droplet associated
 43
 0.96
chr2_112239763_112240639 0.24 Lpcat4
 lysophosphatidylcholine acyltransferase 4
 733
 0.53
chr2_25706786_25707496 0.24 Bmyc
 brain expressed myelocytomatosis oncogene
 402
 0.61
chr2_116790960_116791361 0.24 Gm13990
 predicted gene 13990
 86008
 0.08
chr8_78434733_78435587 0.23 Pou4f2
 POU domain, class 4, transcription factor 2
 1485
 0.43
chr17_43629214_43630519 0.23 Tdrd6
 tudor domain containing 6
 400
 0.83
chr1_93100315_93101980 0.23 Kif1a
 kinesin family member 1A
 675
 0.62
chr11_116653200_116654630 0.23 Prcd
 photoreceptor disc component
 60
 0.83
chr7_35554882_35556130 0.23 B230322F03Rik
 RIKEN cDNA B230322F03 gene
 139
 0.71
chr18_6765228_6765784 0.23 Rab18
 RAB18, member RAS oncogene family
 286
 0.9
chr11_43835659_43836527 0.23 Adra1b
 adrenergic receptor, alpha 1b
 239
 0.95
chr11_98774111_98775335 0.23 Nr1d1
 nuclear receptor subfamily 1, group D, member 1
 610
 0.56
chr15_98792393_98793738 0.22 Wnt1
 wingless-type MMTV integration site family, member 1
 3208
 0.11
chr14_5070665_5071726 0.22 Gm8281
 predicted gene, 8281
 155
 0.94
chr4_106900804_106900955 0.22 Ssbp3
 single-stranded DNA binding protein 3
 9822
 0.2
chr4_76453825_76453976 0.22 Gm42303
 predicted gene, 42303
 2669
 0.3
chr7_4520460_4522358 0.22 Tnni3
 troponin I, cardiac 3
 842
 0.35
chr9_89910732_89911242 0.22 Rasgrf1
 RAS protein-specific guanine nucleotide-releasing factor 1
 1075
 0.57
chr2_29195751_29195902 0.22 Ntng2
 netrin G2
 8198
 0.19
chr7_140899782_140900558 0.22 Cox8b
 cytochrome c oxidase subunit 8B
 276
 0.74
chr1_78016726_78017156 0.22 Gm28387
 predicted gene 28387
 44565
 0.18
chr17_25836281_25837614 0.21 Rhbdl1
 rhomboid like 1
 135
 0.84
chr13_32338049_32338600 0.21 Gmds
 GDP-mannose 4, 6-dehydratase
 261
 0.71
chr11_116840114_116840538 0.21 Jmjd6
 jumonji domain containing 6
 925
 0.4
chr6_145933944_145934978 0.21 Sspn
 sarcospan
 339
 0.86
chr7_100371109_100371874 0.21 Ppme1
 protein phosphatase methylesterase 1
 443
 0.59
chr7_130626987_130627138 0.21 Tacc2
 transforming, acidic coiled-coil containing protein 2
 18419
 0.16
chr19_5039775_5039987 0.20 B4gat1
 beta-1,4-glucuronyltransferase 1
 974
 0.21
chr9_107399475_107400943 0.20 Cacna2d2
 calcium channel, voltage-dependent, alpha 2/delta subunit 2
 140
 0.93
chr17_23993262_23994215 0.20 Prss22
 protease, serine 22
 4362
 0.08
chrX_74328789_74330084 0.20 Plxna3
 plexin A3
 370
 0.67
chr12_112784284_112784667 0.20 Ahnak2
 AHNAK nucleoprotein 2
 3464
 0.13
chr3_41564925_41565593 0.20 Jade1
 jade family PHD finger 1
 339
 0.82
chr11_96274202_96274759 0.20 Hoxb9
 homeobox B9
 2957
 0.1
chr18_34005890_34007297 0.20 Epb41l4a
 erythrocyte membrane protein band 4.1 like 4a
 326
 0.88
chr8_124426147_124426298 0.20 Pgbd5
 piggyBac transposable element derived 5
 7714
 0.21
chr9_50861540_50861809 0.20 Ppp2r1b
 protein phosphatase 2, regulatory subunit A, beta
 4695
 0.18
chr15_76737177_76737328 0.20 Arhgap39
 Rho GTPase activating protein 39
 11649
 0.08
chr2_162661151_162661382 0.20 9430021M05Rik
 RIKEN cDNA 9430021M05 gene
 103
 0.52
chr8_87472820_87473580 0.19 Gm2694
 predicted gene 2694
 43
 0.9
chr7_69492924_69493481 0.19 Gm38584
 predicted gene, 38584
 2401
 0.24
chr3_55055185_55055856 0.19 Ccna1
 cyclin A1
 19
 0.79
chr13_46670045_46670243 0.19 Fam8a1
 family with sequence similarity 8, member A1
 622
 0.69
chr14_79769842_79771877 0.19 Pcdh8
 protocadherin 8
 345
 0.74
chr15_60822830_60824874 0.19 9930014A18Rik
 RIKEN cDNA 9930014A18 gene
 450
 0.73
chr15_98167479_98168718 0.19 Ccdc184
 coiled-coil domain containing 184
 940
 0.4
chr5_71657120_71658579 0.18 Gabra4
 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
 26
 0.79
chr12_112781818_112782096 0.18 Ahnak2
 AHNAK nucleoprotein 2
 946
 0.39
chr8_24674733_24674884 0.18 Adam18
 a disintegrin and metallopeptidase domain 18
 53
 0.97
chr6_50054234_50054467 0.18 Gm3455
 predicted gene 3455
 3164
 0.33
chr4_49844475_49845850 0.18 Grin3a
 glutamate receptor ionotropic, NMDA3A
 387
 0.91
chr5_110543976_110545228 0.18 Galnt9
 polypeptide N-acetylgalactosaminyltransferase 9
 247
 0.9
chr17_35059046_35060516 0.18 Ddah2
 dimethylarginine dimethylaminohydrolase 2
 35
 0.89
chr1_130877918_130878766 0.18 Fcmr
 Fc fragment of IgM receptor
 11
 0.97
chr2_13010530_13011322 0.18 C1ql3
 C1q-like 3
 880
 0.34
chr11_118570728_118570912 0.18 Rbfox3
 RNA binding protein, fox-1 homolog (C. elegans) 3
 910
 0.64
chr11_49168954_49169714 0.18 Btnl9
 butyrophilin-like 9
 1341
 0.28
chr12_112783087_112783238 0.17 Ahnak2
 AHNAK nucleoprotein 2
 2151
 0.18
chr4_146058803_146058954 0.17 Gm13036
 predicted gene 13036
 102
 0.96
chr4_153484340_153484575 0.17 Ajap1
 adherens junction associated protein 1
 1646
 0.54
chr7_4835870_4836475 0.17 Shisa7
 shisa family member 7
 2
 0.94
chr7_79148061_79149306 0.17 Mfge8
 milk fat globule-EGF factor 8 protein
 306
 0.89
chr14_63743158_63744317 0.17 Mir598
 microRNA 598
 16548
 0.21
chr2_120063894_120064045 0.17 Sptbn5
 spectrin beta, non-erythrocytic 5
 21709
 0.1
chr13_25269167_25270348 0.17 Nrsn1
 neurensin 1
 213
 0.96
chr7_4692884_4693035 0.17 Brsk1
 BR serine/threonine kinase 1
 716
 0.43

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 0.7 GO:0048880 sensory system development(GO:0048880)
0.1 0.6 GO:0036233 glycine import(GO:0036233)
0.1 0.8 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 0.3 GO:0021586 pons maturation(GO:0021586)
0.1 0.4 GO:0046959 habituation(GO:0046959)
0.1 0.3 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.2 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 0.2 GO:0035425 autocrine signaling(GO:0035425)
0.1 0.6 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.8 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.1 0.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.2 GO:0061642 chemoattraction of axon(GO:0061642)
0.1 0.2 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 0.2 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.1 0.2 GO:0015817 histidine transport(GO:0015817)
0.1 0.5 GO:0021859 pyramidal neuron differentiation(GO:0021859)
0.1 0.1 GO:0072017 distal tubule development(GO:0072017)
0.0 0.3 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 0.2 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.5 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.6 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.2 GO:0019087 transformation of host cell by virus(GO:0019087)
0.0 0.1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 1.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.1 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.0 0.1 GO:0003358 noradrenergic neuron development(GO:0003358)
0.0 1.1 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.2 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.1 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.0 0.1 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.2 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.2 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 0.1 GO:2001023 regulation of response to drug(GO:2001023)
0.0 0.1 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.2 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.0 0.6 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.1 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.1 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.1 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.1 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.1 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.1 GO:0006566 threonine metabolic process(GO:0006566)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0060486 Clara cell differentiation(GO:0060486)
0.0 0.4 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.2 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 0.0 GO:0060066 oviduct development(GO:0060066)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.1 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882)
0.0 0.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.1 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.0 0.0 GO:0009826 unidimensional cell growth(GO:0009826)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.1 GO:0042891 antibiotic transport(GO:0042891)
0.0 0.3 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.1 GO:0061144 alveolar secondary septum development(GO:0061144)
0.0 0.1 GO:0061511 centriole elongation(GO:0061511)
0.0 0.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.3 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.0 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0 0.1 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.0 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.0 GO:0042360 vitamin E metabolic process(GO:0042360)
0.0 0.0 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.0 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.0 0.1 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.0 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130)
0.0 0.0 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.0 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.0 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0 0.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.0 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.0 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.3 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.0 0.0 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
0.0 0.0 GO:0032079 positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.0 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.0 GO:0086045 membrane depolarization during AV node cell action potential(GO:0086045)
0.0 0.0 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.0 GO:1903416 response to glycoside(GO:1903416)
0.0 0.0 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.0 GO:0071873 response to norepinephrine(GO:0071873)
0.0 0.4 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.1 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.0 GO:2001286 regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.0 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.0 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.1 GO:0008090 retrograde axonal transport(GO:0008090)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.2 GO:0030689 Noc complex(GO:0030689)
0.1 0.6 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0034709 methylosome(GO:0034709)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.1 GO:0016234 inclusion body(GO:0016234)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.0 GO:0005608 laminin-3 complex(GO:0005608)
0.0 0.0 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.1 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.8 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 0.3 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.2 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.3 GO:0043731 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0 0.1 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.1 GO:0043199 sulfate binding(GO:0043199)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.0 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0042895 antibiotic transporter activity(GO:0042895)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.0 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.7 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0019176 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.5 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.0 GO:0070905 serine binding(GO:0070905)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.0 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.0 0.0 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.0 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.2 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.0 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.1 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1