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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hif1a

Z-value: 0.54

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Transcription factors associated with Hif1a

Gene Symbol	Gene ID	Gene Info
Hif1a Ensembl NCBI MGI UniProt	ENSMUSG00000021109.7	Hif1a

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hif1a	chr12_73901338_73901489	38	0.973379	-0.25	5.2e-02	Click!
Hif1a	chr12_73916045_73916196	8216	0.158013	0.24	6.9e-02	Click!
Hif1a	chr12_73912214_73912365	4385	0.185784	0.15	2.5e-01	Click!
Hif1a	chr12_73913244_73913533	5484	0.173465	0.11	4.1e-01	Click!
Hif1a	chr12_73902065_73902216	765	0.619039	0.11	4.1e-01	Click!

Activity of the Hif1a motif across conditions

Conditions sorted by the z-value of the Hif1a motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_118568846_118570341	1.29	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	317	0.91
chr13_54765549_54766801	1.09	Sncb	synuclein, beta	78	0.95
chr7_44336079_44337576	0.96	Shank1	SH3 and multiple ankyrin repeat domains 1	811	0.34
chr2_152081612_152083149	0.95	Scrt2	scratch family zinc finger 2	851	0.52
chrX_110814269_110815716	0.88	Pou3f4	POU domain, class 3, transcription factor 4	712	0.71
chr7_121391567_121393161	0.78	Hs3st2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	74	0.93
chr1_42697532_42698715	0.77	Pou3f3	POU domain, class 3, transcription factor 3	2355	0.2
chr4_138394975_138396803	0.75	Fam43b	family with sequence similarity 43, member B	639	0.41
chr7_87584098_87584781	0.71	Grm5	glutamate receptor, metabotropic 5	41	0.99
chr11_3331744_3332343	0.70	Pik3ip1	phosphoinositide-3-kinase interacting protein 1	29	0.93
chr14_3571642_3572719	0.67	Gm3005	predicted gene 3005	157	0.94
chr19_44674504_44675304	0.66	Gm26644	predicted gene, 26644	20371	0.15
chr2_22895605_22896237	0.66	Pdss1	prenyl (solanesyl) diphosphate synthase, subunit 1	127	0.58
chr13_116302578_116304501	0.65	Isl1	ISL1 transcription factor, LIM/homeodomain	188	0.96
chr14_3809696_3810741	0.65	Gm3002	predicted gene 3002	144	0.94
chr14_5812168_5813063	0.64	Gm3383	predicted gene 3383	4633	0.14
chr14_4018473_4019517	0.63	Gm5796	predicted gene 5796	4946	0.14
chr1_91344585_91345841	0.63	Klhl30	kelch-like 30	5803	0.11
chr14_19584548_19585598	0.63	Gm2237	predicted gene 2237	62	0.95
chr8_119394920_119395525	0.62	Mlycd	malonyl-CoA decarboxylase	324	0.87
chr19_5695606_5696740	0.62	Map3k11	mitogen-activated protein kinase kinase kinase 11	3278	0.08
chr14_4726384_4727541	0.62	Gm3252	predicted gene 3252	187	0.91
chr14_6756399_6757462	0.61	Gm3636	predicted gene 3636	14598	0.14
chr14_4498814_4499998	0.60	Gm3173	predicted gene 3173	15352	0.11
chr14_6286765_6287923	0.60	Gm3411	predicted gene 3411	94	0.95
chr7_49911362_49912424	0.60	Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	193	0.96
chr14_3412245_3413254	0.58	Gm10409	predicted gene 10409	135	0.93
chr15_80287040_80287449	0.57	Cacna1i	calcium channel, voltage-dependent, alpha 1I subunit	6	0.97
chr14_5459633_5460571	0.57	Gm3194	predicted gene 3194	4635	0.14
chr9_87015230_87016430	0.57	Ripply2	ripply transcriptional repressor 2	194	0.94
chr14_7026733_7027810	0.56	Gm10406	predicted gene 10406	178	0.93
chr4_22486897_22487389	0.56	Pou3f2	POU domain, class 3, transcription factor 2	1223	0.42
chr9_45430098_45431532	0.56	4833428L15Rik	RIKEN cDNA 4833428L15 gene	417	0.52
chr10_81272581_81272732	0.56	Apba3	amyloid beta (A4) precursor protein-binding, family A, member 3	38	0.9
chr14_6426291_6427481	0.55	Lamtor3-ps	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, pseudogene	14404	0.14
chr2_128758874_128759147	0.54	Gm14011	predicted gene 14011	5305	0.16
chr14_7173946_7175014	0.54	Gm3512	predicted gene 3512	53	0.97
chr14_3332235_3333462	0.54	Gm2956	predicted gene 2956	221	0.91
chr14_7487792_7489005	0.52	Gm3752	predicted gene 3752	4636	0.16
chr14_4182195_4183376	0.52	Gm2974	predicted gene 2974	209	0.91
chrX_136666183_136667703	0.52	Tceal3	transcription elongation factor A (SII)-like 3	332	0.84
chr14_7657902_7658985	0.51	Gm10128	predicted gene 10128	14471	0.16
chr14_5501278_5502453	0.50	Gm3488	predicted gene, 3488	191	0.9
chr7_46348707_46349190	0.50	1700025L06Rik	RIKEN cDNA 1700025L06 gene	106	0.96
chr4_107823086_107824019	0.49	Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	391	0.53
chr3_73053153_73054210	0.48	Slitrk3	SLIT and NTRK-like family, member 3	3262	0.23
chr2_164967685_164969910	0.47	Slc12a5	solute carrier family 12, member 5	516	0.7
chr14_5148637_5149909	0.46	Gm3317	predicted gene 3317	15262	0.11
chr17_51461105_51461697	0.45	Gm46574	predicted gene, 46574	23320	0.19
chr7_98193340_98194780	0.45	B3gnt6	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)	5421	0.16
chr14_7104815_7105770	0.45	Gm3696	predicted gene 3696	4671	0.16
chr16_8424071_8425359	0.45	Tmem114	transmembrane protein 114	421	0.83
chr14_6107781_6108962	0.45	Gm3468	predicted gene 3468	294	0.84
chr7_137318563_137320070	0.44	Ebf3	early B cell factor 3	4871	0.21
chr14_4334314_4335468	0.44	2610042L04Rik	RIKEN cDNA 2610042L04 gene	128	0.95
chr14_3651660_3652927	0.42	Gm3020	predicted gene 3020	263	0.87
chr7_79504311_79505700	0.42	Mir9-3	microRNA 9-3	259	0.82
chr1_177446374_177448525	0.41	Zbtb18	zinc finger and BTB domain containing 18	1628	0.31
chr5_37241461_37244349	0.40	Crmp1	collapsin response mediator protein 1	171	0.95
chr11_69800783_69801791	0.40	Fgf11	fibroblast growth factor 11	429	0.56
chr6_48628821_48630012	0.39	AI854703	expressed sequence AI854703	1481	0.18
chr14_65423052_65425451	0.39	Pnoc	prepronociceptin	909	0.6
chr2_156613822_156614400	0.38	Dlgap4	DLG associated protein 4	406	0.56
chr11_47988311_47989415	0.38	Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	106	0.98
chr16_43979809_43980249	0.38	Zdhhc23	zinc finger, DHHC domain containing 23	238	0.91
chr13_39653133_39653284	0.38	Gm32243	predicted gene, 32243	5961	0.22
chr2_156614815_156615561	0.38	Gm14174	predicted gene 14174	260	0.82
chr11_82388570_82389922	0.37	Tmem132e	transmembrane protein 132E	123	0.96
chr2_25318080_25319601	0.37	Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	255	0.77
chr14_4855192_4856263	0.37	Gm3264	predicted gene 3264	151	0.94
chr7_44985301_44986386	0.37	Prmt1	protein arginine N-methyltransferase 1	473	0.48
chr5_139546076_139547826	0.37	Uncx	UNC homeobox	3053	0.23
chr18_65430358_65430843	0.36	Malt1	MALT1 paracaspase	338	0.82
chr3_144396551_144396705	0.36	Gm5857	predicted gene 5857	31044	0.17
chr14_32462734_32463939	0.36	Chat	choline acetyltransferase	1294	0.28
chr8_41054476_41055299	0.36	Mtus1	mitochondrial tumor suppressor 1	93	0.95
chr5_122950311_122951097	0.35	Kdm2b	lysine (K)-specific demethylase 2B	1286	0.34
chr11_68384940_68385629	0.35	Ntn1	netrin 1	1542	0.44
chr12_112928791_112929397	0.35	Jag2	jagged 2	646	0.51
chr11_11113816_11114856	0.34	Vwc2	von Willebrand factor C domain containing 2	113	0.98
chr2_70561988_70564432	0.34	Gad1os	glutamate decarboxylase 1, opposite strand	147	0.61
chr7_25180336_25182324	0.34	Pou2f2	POU domain, class 2, transcription factor 2	1604	0.22
chr5_120409346_120410480	0.34	Lhx5	LIM homeobox protein 5	21786	0.12
chr8_29218667_29220085	0.34	Unc5d	unc-5 netrin receptor D	51	0.98
chr10_84754760_84756248	0.34	Rfx4	regulatory factor X, 4 (influences HLA class II expression)	558	0.8
chr5_110652833_110653341	0.34	Noc4l	NOC4 like	172	0.69
chr14_6889307_6890296	0.33	Gm3667	predicted gene 3667	161	0.95
chr1_17097801_17097987	0.33	Jph1	junctophilin 1	5	0.98
chr9_37433470_37434351	0.33	Robo3	roundabout guidance receptor 3	664	0.59
chr18_42394146_42396205	0.33	Pou4f3	POU domain, class 4, transcription factor 3	100	0.97
chr9_90162957_90164072	0.33	Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	288	0.88
chr13_95989973_95990124	0.32	Sv2c	synaptic vesicle glycoprotein 2c	178	0.96
chr4_82513112_82513640	0.32	Gm11266	predicted gene 11266	5360	0.22
chr11_119190727_119190895	0.32	Gm11753	predicted gene 11753	6295	0.13
chr7_99182821_99183252	0.32	Dgat2	diacylglycerol O-acyltransferase 2	317	0.84
chr4_42917314_42917764	0.31	Phf24	PHD finger protein 24	205	0.91
chr7_78989959_78991095	0.31	Gm26633	predicted gene, 26633	62796	0.08
chr3_54915029_54916379	0.31	Sertm1	serine rich and transmembrane domain containing 1	183	0.96
chr9_91363965_91365514	0.31	Zic1	zinc finger protein of the cerebellum 1	1029	0.35
chr2_6322398_6322669	0.31	Usp6nl	USP6 N-terminal like	134	0.86
chr3_139205663_139206386	0.31	Stpg2	sperm tail PG rich repeat containing 2	131	0.98
chr13_52529695_52530820	0.31	Diras2	DIRAS family, GTP-binding RAS-like 2	1022	0.66
chr9_72925072_72926177	0.31	Pygo1	pygopus 1	21	0.95
chrX_166238673_166239964	0.31	Gpm6b	glycoprotein m6b	346	0.9
chr1_157243489_157244692	0.30	Rasal2	RAS protein activator like 2	400	0.88
chr10_78746927_78747974	0.30	Gm30400	predicted gene, 30400	291	0.84
chr15_75746536_75747326	0.29	Mafa	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	1297	0.33
chr5_111419755_111420664	0.29	Mn1	meningioma 1	2767	0.22
chr2_28195247_28196182	0.29	Olfm1	olfactomedin 1	2621	0.32
chr10_80226705_80227856	0.29	Pwwp3a	PWWP domain containing 3A, DNA repair factor	529	0.58
chr7_99468579_99468981	0.29	Klhl35	kelch-like 35	183	0.9
chr7_46179165_46180456	0.29	Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	176	0.92
chr2_25567077_25567419	0.28	Mamdc4	MAM domain containing 4	1867	0.13
chr7_126692598_126692845	0.28	Bola2	bolA-like 2 (E. coli)	2680	0.09
chr4_62499250_62499401	0.28	Hdhd3	haloacid dehalogenase-like hydrolase domain containing 3	2951	0.15
chr1_34579671_34580338	0.28	1700101I19Rik	RIKEN cDNA 1700101I19 gene	293	0.5
chr7_112225522_112225723	0.28	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	234	0.96
chr7_141221857_141222428	0.28	Mir210	microRNA 210	649	0.44
chr10_41070697_41071486	0.28	Gpr6	G protein-coupled receptor 6	1194	0.41
chr18_40256495_40257230	0.28	Kctd16	potassium channel tetramerisation domain containing 16	100	0.96
chr13_18948071_18948332	0.27	Amph	amphiphysin	4	0.97
chr12_112779696_112780559	0.27	Ahnak2	AHNAK nucleoprotein 2	884	0.42
chr1_180894021_180894978	0.27	Lefty2	left-right determination factor 2	41	0.95
chr5_36529349_36530504	0.27	Tbc1d14	TBC1 domain family, member 14	581	0.71
chr9_53705377_53706662	0.26	Rab39	RAB39, member RAS oncogene family	213	0.91
chr19_45228695_45230660	0.26	Lbx1	ladybird homeobox 1	6135	0.2
chr5_73006697_73007924	0.25	Slc10a4	solute carrier family 10 (sodium/bile acid cotransporter family), member 4	407	0.74
chr7_5052519_5053499	0.25	Zfp580	zinc finger protein 580	1020	0.21
chr15_76517568_76519917	0.25	Scrt1	scratch family zinc finger 1	3160	0.09
chr6_128842519_128843166	0.25	Gm44066	predicted gene, 44066	329	0.76
chr4_134747576_134747727	0.25	Ldlrap1	low density lipoprotein receptor adaptor protein 1	2456	0.3
chr1_181352204_181352681	0.25	Cnih3	cornichon family AMPA receptor auxiliary protein 3	186	0.94
chr6_39256378_39257582	0.24	Gm26008	predicted gene, 26008	8962	0.16
chr14_70079421_70080436	0.24	Egr3	early growth response 3	1189	0.41
chr6_29272372_29272690	0.24	Hilpda	hypoxia inducible lipid droplet associated	43	0.96
chr2_112239763_112240639	0.24	Lpcat4	lysophosphatidylcholine acyltransferase 4	733	0.53
chr2_25706786_25707496	0.24	Bmyc	brain expressed myelocytomatosis oncogene	402	0.61
chr2_116790960_116791361	0.24	Gm13990	predicted gene 13990	86008	0.08
chr8_78434733_78435587	0.23	Pou4f2	POU domain, class 4, transcription factor 2	1485	0.43
chr17_43629214_43630519	0.23	Tdrd6	tudor domain containing 6	400	0.83
chr1_93100315_93101980	0.23	Kif1a	kinesin family member 1A	675	0.62
chr11_116653200_116654630	0.23	Prcd	photoreceptor disc component	60	0.83
chr7_35554882_35556130	0.23	B230322F03Rik	RIKEN cDNA B230322F03 gene	139	0.71
chr18_6765228_6765784	0.23	Rab18	RAB18, member RAS oncogene family	286	0.9
chr11_43835659_43836527	0.23	Adra1b	adrenergic receptor, alpha 1b	239	0.95
chr11_98774111_98775335	0.23	Nr1d1	nuclear receptor subfamily 1, group D, member 1	610	0.56
chr15_98792393_98793738	0.22	Wnt1	wingless-type MMTV integration site family, member 1	3208	0.11
chr14_5070665_5071726	0.22	Gm8281	predicted gene, 8281	155	0.94
chr4_106900804_106900955	0.22	Ssbp3	single-stranded DNA binding protein 3	9822	0.2
chr4_76453825_76453976	0.22	Gm42303	predicted gene, 42303	2669	0.3
chr7_4520460_4522358	0.22	Tnni3	troponin I, cardiac 3	842	0.35
chr9_89910732_89911242	0.22	Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	1075	0.57
chr2_29195751_29195902	0.22	Ntng2	netrin G2	8198	0.19
chr7_140899782_140900558	0.22	Cox8b	cytochrome c oxidase subunit 8B	276	0.74
chr1_78016726_78017156	0.22	Gm28387	predicted gene 28387	44565	0.18
chr17_25836281_25837614	0.21	Rhbdl1	rhomboid like 1	135	0.84
chr13_32338049_32338600	0.21	Gmds	GDP-mannose 4, 6-dehydratase	261	0.71
chr11_116840114_116840538	0.21	Jmjd6	jumonji domain containing 6	925	0.4
chr6_145933944_145934978	0.21	Sspn	sarcospan	339	0.86
chr7_100371109_100371874	0.21	Ppme1	protein phosphatase methylesterase 1	443	0.59
chr7_130626987_130627138	0.21	Tacc2	transforming, acidic coiled-coil containing protein 2	18419	0.16
chr19_5039775_5039987	0.20	B4gat1	beta-1,4-glucuronyltransferase 1	974	0.21
chr9_107399475_107400943	0.20	Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	140	0.93
chr17_23993262_23994215	0.20	Prss22	protease, serine 22	4362	0.08
chrX_74328789_74330084	0.20	Plxna3	plexin A3	370	0.67
chr12_112784284_112784667	0.20	Ahnak2	AHNAK nucleoprotein 2	3464	0.13
chr3_41564925_41565593	0.20	Jade1	jade family PHD finger 1	339	0.82
chr11_96274202_96274759	0.20	Hoxb9	homeobox B9	2957	0.1
chr18_34005890_34007297	0.20	Epb41l4a	erythrocyte membrane protein band 4.1 like 4a	326	0.88
chr8_124426147_124426298	0.20	Pgbd5	piggyBac transposable element derived 5	7714	0.21
chr9_50861540_50861809	0.20	Ppp2r1b	protein phosphatase 2, regulatory subunit A, beta	4695	0.18
chr15_76737177_76737328	0.20	Arhgap39	Rho GTPase activating protein 39	11649	0.08
chr2_162661151_162661382	0.20	9430021M05Rik	RIKEN cDNA 9430021M05 gene	103	0.52
chr8_87472820_87473580	0.19	Gm2694	predicted gene 2694	43	0.9
chr7_69492924_69493481	0.19	Gm38584	predicted gene, 38584	2401	0.24
chr3_55055185_55055856	0.19	Ccna1	cyclin A1	19	0.79
chr13_46670045_46670243	0.19	Fam8a1	family with sequence similarity 8, member A1	622	0.69
chr14_79769842_79771877	0.19	Pcdh8	protocadherin 8	345	0.74
chr15_60822830_60824874	0.19	9930014A18Rik	RIKEN cDNA 9930014A18 gene	450	0.73
chr15_98167479_98168718	0.19	Ccdc184	coiled-coil domain containing 184	940	0.4
chr5_71657120_71658579	0.18	Gabra4	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4	26	0.79
chr12_112781818_112782096	0.18	Ahnak2	AHNAK nucleoprotein 2	946	0.39
chr8_24674733_24674884	0.18	Adam18	a disintegrin and metallopeptidase domain 18	53	0.97
chr6_50054234_50054467	0.18	Gm3455	predicted gene 3455	3164	0.33
chr4_49844475_49845850	0.18	Grin3a	glutamate receptor ionotropic, NMDA3A	387	0.91
chr5_110543976_110545228	0.18	Galnt9	polypeptide N-acetylgalactosaminyltransferase 9	247	0.9
chr17_35059046_35060516	0.18	Ddah2	dimethylarginine dimethylaminohydrolase 2	35	0.89
chr1_130877918_130878766	0.18	Fcmr	Fc fragment of IgM receptor	11	0.97
chr2_13010530_13011322	0.18	C1ql3	C1q-like 3	880	0.34
chr11_118570728_118570912	0.18	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	910	0.64
chr11_49168954_49169714	0.18	Btnl9	butyrophilin-like 9	1341	0.28
chr12_112783087_112783238	0.17	Ahnak2	AHNAK nucleoprotein 2	2151	0.18
chr4_146058803_146058954	0.17	Gm13036	predicted gene 13036	102	0.96
chr4_153484340_153484575	0.17	Ajap1	adherens junction associated protein 1	1646	0.54
chr7_4835870_4836475	0.17	Shisa7	shisa family member 7	2	0.94
chr7_79148061_79149306	0.17	Mfge8	milk fat globule-EGF factor 8 protein	306	0.89
chr14_63743158_63744317	0.17	Mir598	microRNA 598	16548	0.21
chr2_120063894_120064045	0.17	Sptbn5	spectrin beta, non-erythrocytic 5	21709	0.1
chr13_25269167_25270348	0.17	Nrsn1	neurensin 1	213	0.96
chr7_4692884_4693035	0.17	Brsk1	BR serine/threonine kinase 1	716	0.43

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2	0.7	GO:0048880	sensory system development(GO:0048880)
0.1	0.6	GO:0036233	glycine import(GO:0036233)
0.1	0.8	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1	0.3	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.1	0.3	GO:0021586	pons maturation(GO:0021586)
0.1	0.4	GO:0046959	habituation(GO:0046959)
0.1	0.3	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1	0.3	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.2	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
0.1	0.2	GO:0035425	autocrine signaling(GO:0035425)
0.1	0.6	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.4	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.1	0.3	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1	0.8	GO:0035337	fatty-acyl-CoA metabolic process(GO:0035337)
0.1	0.3	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1	0.2	GO:0061642	chemoattraction of axon(GO:0061642)
0.1	0.2	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1	0.2	GO:0001923	B-1 B cell differentiation(GO:0001923)
0.1	0.2	GO:0015817	histidine transport(GO:0015817)
0.1	0.5	GO:0021859	pyramidal neuron differentiation(GO:0021859)
0.1	0.1	GO:0072017	distal tubule development(GO:0072017)
0.0	0.3	GO:0021562	vestibulocochlear nerve development(GO:0021562)
0.0	0.2	GO:0090383	phagosome acidification(GO:0090383)
0.0	0.5	GO:2001054	negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0	0.2	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.2	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.0	0.6	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.2	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	1.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.0	0.3	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.1	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.1	GO:0003358	noradrenergic neuron development(GO:0003358)
0.0	1.1	GO:0042417	dopamine metabolic process(GO:0042417)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.2	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.4	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.1	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.0	0.1	GO:0033693	neurofilament bundle assembly(GO:0033693)
0.0	0.2	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.3	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.2	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.2	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.2	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.0	0.1	GO:2001023	regulation of response to drug(GO:2001023)
0.0	0.1	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.3	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.0	0.6	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0	0.1	GO:0050975	sensory perception of touch(GO:0050975)
0.0	0.1	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.1	GO:0023041	neuronal signal transduction(GO:0023041)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.1	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.1	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.1	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.2	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0060486	Clara cell differentiation(GO:0060486)
0.0	0.4	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.2	GO:0097341	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0	0.1	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.0	0.1	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0	0.0	GO:0060066	oviduct development(GO:0060066)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.1	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882)
0.0	0.3	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.0	0.1	GO:1901857	positive regulation of cellular respiration(GO:1901857)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.1	GO:1904659	glucose transmembrane transport(GO:1904659)
0.0	0.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.2	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.4	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.5	GO:2001222	regulation of neuron migration(GO:2001222)
0.0	0.1	GO:0042891	antibiotic transport(GO:0042891)
0.0	0.3	GO:0007289	spermatid nucleus differentiation(GO:0007289)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.0	0.1	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.1	GO:0061511	centriole elongation(GO:0061511)
0.0	0.1	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.1	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.1	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.3	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.0	GO:0009177	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.1	GO:0009191	ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.2	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.0	GO:0035582	sequestering of BMP in extracellular matrix(GO:0035582)
0.0	0.1	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.0	GO:0035633	maintenance of blood-brain barrier(GO:0035633)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.1	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.0	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130)
0.0	0.0	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.0	GO:0099558	maintenance of synapse structure(GO:0099558)
0.0	0.0	GO:0048682	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.0	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0	0.3	GO:1900449	regulation of glutamate receptor signaling pathway(GO:1900449)
0.0	0.0	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.0	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.0	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.0	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.0	GO:1903416	response to glycoside(GO:1903416)
0.0	0.0	GO:0001927	exocyst assembly(GO:0001927)
0.0	0.0	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.4	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	0.2	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0048007	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0	0.1	GO:0006004	fucose metabolic process(GO:0006004)
0.0	0.0	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.0	GO:0001887	selenium compound metabolic process(GO:0001887)
0.0	0.0	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.0	0.1	GO:0008090	retrograde axonal transport(GO:0008090)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	0.9	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	0.4	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	0.2	GO:0030689	Noc complex(GO:0030689)
0.1	0.6	GO:0097449	astrocyte projection(GO:0097449)
0.1	0.2	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	1.1	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.6	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.2	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.2	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.5	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.2	GO:0034709	methylosome(GO:0034709)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279)
0.0	1.1	GO:0016234	inclusion body(GO:0016234)
0.0	1.8	GO:0043204	perikaryon(GO:0043204)
0.0	0.2	GO:0033391	chromatoid body(GO:0033391)
0.0	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.0	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.0	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0	0.1	GO:0005861	troponin complex(GO:0005861)
0.0	0.2	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.2	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.1	0.6	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.1	0.4	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.1	0.8	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.3	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	0.2	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.1	0.5	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.3	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	0.2	GO:0030519	snoRNP binding(GO:0030519)
0.1	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.5	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	1.0	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.2	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.3	GO:0043731	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0043199	sulfate binding(GO:0043199)
0.0	1.2	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.0	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.2	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.4	GO:0031005	filamin binding(GO:0031005)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0	0.3	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.1	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.0	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.7	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.2	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.0	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.3	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.1	GO:0097603	temperature-gated ion channel activity(GO:0097603)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.4	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0	0.7	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.5	GO:0050699	WW domain binding(GO:0050699)
0.0	0.2	GO:0019176	thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.0	0.5	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	0.0	GO:0070905	serine binding(GO:0070905)
0.0	0.3	GO:0005112	Notch binding(GO:0005112)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.0	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.0	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.4	PID REELIN PATHWAY	Reelin signaling pathway
0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.6	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.6	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.6	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.3	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.1	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.7	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.2	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.0	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.1	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.2	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1