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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hlx

Z-value: 0.59

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Transcription factors associated with Hlx

Gene Symbol	Gene ID	Gene Info
Hlx Ensembl NCBI MGI UniProt	ENSMUSG00000039377.6	Hlx

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hlx	chr1_184733855_184734791	1704	0.268399	-0.61	2.9e-07	Click!
Hlx	chr1_184731287_184732512	301	0.862596	-0.54	7.9e-06	Click!
Hlx	chr1_184732758_184733253	386	0.805138	-0.49	6.2e-05	Click!
Hlx	chr1_184729496_184731200	1250	0.373544	-0.44	4.1e-04	Click!
Hlx	chr1_184728502_184729126	2784	0.197330	-0.43	7.1e-04	Click!

Activity of the Hlx motif across conditions

Conditions sorted by the z-value of the Hlx motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_70842167_70842810	2.36	Gabrg1	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	129	0.98
chr5_120426818_120428597	2.14	Lhx5	LIM homeobox protein 5	3992	0.15
chr7_87586513_87587584	1.91	Grm5	glutamate receptor, metabotropic 5	2650	0.4
chr18_43686213_43686392	1.88	Jakmip2	janus kinase and microtubule interacting protein 2	1323	0.49
chr13_69734884_69735178	1.85	Ube2ql1	ubiquitin-conjugating enzyme E2Q family-like 1	4858	0.14
chr14_66865047_66865736	1.83	Dpysl2	dihydropyrimidinase-like 2	3297	0.19
chr3_8512495_8512918	1.63	Stmn2	stathmin-like 2	3120	0.28
chr14_55056074_55056891	1.48	Gm20687	predicted gene 20687	989	0.3
chr1_169745785_169746010	1.47	Rgs4	regulator of G-protein signaling 4	1726	0.41
chr15_103058659_103059955	1.40	5730585A16Rik	RIKEN cDNA 5730585A16 gene	1	0.95
chr9_52148115_52149635	1.36	Zc3h12c	zinc finger CCCH type containing 12C	19236	0.18
chr8_34890130_34891317	1.19	Tnks	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	572	0.8
chr18_59062200_59063436	1.19	Minar2	membrane integral NOTCH2 associated receptor 2	307	0.94
chr3_38894285_38895428	1.11	Fat4	FAT atypical cadherin 4	3914	0.27
chr3_89521563_89522618	1.08	Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	1926	0.28
chr3_63961199_63961587	1.08	Gm26850	predicted gene, 26850	2240	0.21
chr18_54719777_54720132	1.07	Gm5821	predicted gene 5821	46178	0.16
chr1_177448882_177449429	1.04	Zbtb18	zinc finger and BTB domain containing 18	3334	0.19
chr18_25745414_25746450	1.00	Celf4	CUGBP, Elav-like family member 4	6760	0.24
chr2_123533004_123533690	1.00	Gm13988	predicted gene 13988	259423	0.02
chr9_41585694_41587243	0.97	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	1301	0.29
chr3_134236641_134237783	0.97	Cxxc4	CXXC finger 4	392	0.78
chr7_123984527_123984925	0.96	Gm27040	predicted gene, 27040	1272	0.38
chr3_86748624_86748824	0.93	Gm37876	predicted gene, 37876	29929	0.17
chr7_137305711_137306880	0.92	Ebf3	early B cell factor 3	7621	0.2
chr8_78433398_78433999	0.90	Pou4f2	POU domain, class 4, transcription factor 2	2947	0.27
chr14_108912235_108913525	0.89	Slitrk1	SLIT and NTRK-like family, member 1	1278	0.64
chr1_9296437_9296701	0.89	Sntg1	syntrophin, gamma 1	1667	0.35
chr10_69536775_69537233	0.89	Ank3	ankyrin 3, epithelial	2782	0.32
chr5_135248496_135249658	0.87	Fzd9	frizzled class receptor 9	2153	0.21
chr11_32001099_32002296	0.87	Nsg2	neuron specific gene family member 2	1195	0.52
chr2_146061763_146063020	0.86	Cfap61	cilia and flagella associated protein 61	15140	0.25
chr2_151631540_151632560	0.85	Snph	syntaphilin	421	0.78
chr1_115688015_115688174	0.85	Cntnap5a	contactin associated protein-like 5A	3338	0.29
chr1_136228373_136230942	0.84	Inava	innate immunity activator	362	0.76
chr13_104111586_104112312	0.81	Sgtb	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	2120	0.26
chr4_33926104_33927188	0.81	Cnr1	cannabinoid receptor 1 (brain)	444	0.88
chr12_31711352_31711698	0.80	Gpr22	G protein-coupled receptor 22	2401	0.25
chr5_37241461_37244349	0.78	Crmp1	collapsin response mediator protein 1	171	0.95
chr19_44748114_44748265	0.78	Gm35610	predicted gene, 35610	6836	0.15
chr7_79504311_79505700	0.78	Mir9-3	microRNA 9-3	259	0.82
chr18_37217058_37218378	0.78	Gm10544	predicted gene 10544	39196	0.08
chr6_112609185_112609336	0.76	Gm5578	predicted pseudogene 5578	3716	0.21
chr7_99275133_99275418	0.76	Map6	microtubule-associated protein 6	6143	0.13
chr19_20009817_20010437	0.75	Gm22684	predicted gene, 22684	23508	0.22
chr13_83736071_83736534	0.75	Gm33366	predicted gene, 33366	2233	0.18
chr11_23893045_23893724	0.74	Gm12061	predicted gene 12061	1176	0.38
chr15_85682337_85682535	0.72	Lncppara	long noncoding RNA near Ppara	21337	0.12
chr3_4796861_4798079	0.71	1110015O18Rik	RIKEN cDNA 1110015O18 gene	88	0.98
chr12_79814152_79814328	0.71	9430078K24Rik	RIKEN cDNA 9430078K24 gene	110493	0.06
chr2_163977230_163977381	0.71	Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	17655	0.16
chr4_99659246_99659665	0.70	Gm23366	predicted gene, 23366	1713	0.26
chr9_56159774_56159955	0.70	Tspan3	tetraspanin 3	678	0.68
chr14_104641438_104641957	0.69	D130009I18Rik	RIKEN cDNA D130009I18 gene	2553	0.3
chrX_6171274_6171425	0.69	Nudt10	nudix (nucleoside diphosphate linked moiety X)-type motif 10	1666	0.4
chr12_117345149_117346019	0.67	Gm5441	predicted gene 5441	8562	0.29
chr10_94941542_94941964	0.66	Plxnc1	plexin C1	3082	0.28
chr11_96002027_96002959	0.66	Gm29202	predicted gene 29202	3396	0.11
chr11_111605019_111605670	0.65	Gm11676	predicted gene 11676	7962	0.32
chr13_20472048_20472724	0.64	Elmo1	engulfment and cell motility 1	340	0.8
chr3_34654574_34655689	0.64	Sox2ot	SOX2 overlapping transcript (non-protein coding)	905	0.42
chr19_12498310_12498475	0.64	Dtx4	deltex 4, E3 ubiquitin ligase	3062	0.14
chr3_119154592_119155474	0.64	Gm43410	predicted gene 43410	286789	0.01
chr14_104463807_104464161	0.64	Pou4f1	POU domain, class 4, transcription factor 1	1381	0.4
chr1_19213854_19215338	0.63	Tfap2b	transcription factor AP-2 beta	717	0.69
chr14_64233514_64233974	0.63	9630015K15Rik	RIKEN cDNA 9630015K15 gene	117430	0.05
chr1_172341079_172341970	0.63	Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	314	0.81
chr6_7554855_7556232	0.62	Tac1	tachykinin 1	447	0.85
chr12_46813712_46814094	0.62	Gm48542	predicted gene, 48542	2395	0.29
chr19_47018258_47018719	0.60	Nt5c2	5'-nucleotidase, cytosolic II	3335	0.15
chr7_51629095_51630495	0.58	Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	315	0.88
chr2_65620767_65621991	0.57	Scn2a	sodium channel, voltage-gated, type II, alpha	568	0.82
chr8_110275623_110275994	0.56	Gm26832	predicted gene, 26832	8346	0.19
chr15_92598307_92599654	0.56	Pdzrn4	PDZ domain containing RING finger 4	1854	0.49
chr9_74869680_74869831	0.55	Onecut1	one cut domain, family member 1	3271	0.2
chr9_75681964_75682559	0.55	Scg3	secretogranin III	1326	0.37
chr2_152080491_152081480	0.54	Scrt2	scratch family zinc finger 2	544	0.7
chr5_63651264_63652181	0.54	Gm9954	predicted gene 9954	828	0.61
chr1_15288505_15288656	0.53	Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	1326	0.51
chr8_41052368_41053980	0.53	Gm16193	predicted gene 16193	64	0.96
chr14_122481884_122483266	0.53	Zic2	zinc finger protein of the cerebellum 2	4475	0.12
chr2_116073034_116073185	0.52	2810405F15Rik	RIKEN cDNA 2810405F15 gene	2987	0.22
chr18_72349127_72350542	0.52	Dcc	deleted in colorectal carcinoma	1183	0.64
chr3_86543379_86544222	0.51	Lrba	LPS-responsive beige-like anchor	1767	0.38
chr3_131341006_131341355	0.51	Sgms2	sphingomyelin synthase 2	3753	0.2
chr10_89875205_89875398	0.50	Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	1629	0.45
chr17_67499984_67500234	0.50	Gm36201	predicted gene, 36201	129223	0.05
chr12_52700044_52701597	0.50	Akap6	A kinase (PRKA) anchor protein 6	1437	0.46
chr15_18819282_18819740	0.50	Cdh10	cadherin 10	534	0.58
chr7_35848412_35848964	0.49	Gm28514	predicted gene 28514	10428	0.21
chr11_96593909_96594964	0.48	Skap1	src family associated phosphoprotein 1	104575	0.05
chr4_128885478_128885629	0.48	Trim62	tripartite motif-containing 62	1965	0.27
chr10_90578974_90579573	0.48	Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	2281	0.42
chr10_90577565_90578158	0.47	Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	869	0.72
chrX_153501207_153502250	0.47	Ubqln2	ubiquilin 2	3501	0.22
chr2_72426765_72427714	0.47	Cdca7	cell division cycle associated 7	48920	0.13
chr8_47345612_47345906	0.46	Stox2	storkhead box 2	6589	0.26
chr11_84520959_84524590	0.46	Lhx1	LIM homeobox protein 1	63	0.97
chr18_42429204_42429681	0.46	Gm16415	predicted pseudogene 16415	11577	0.18
chr4_124254790_124255065	0.46	Gm37667	predicted gene, 37667	24250	0.16
chr9_91404809_91406365	0.45	Gm29478	predicted gene 29478	1113	0.42
chr17_56241459_56242409	0.45	A230051N06Rik	RIKEN cDNA A230051N06 gene	218	0.81
chr10_45889498_45890055	0.44	Gpx4-ps2	glutathione peroxidase 4, pseudogene 2	14471	0.23
chr7_70355803_70356454	0.43	Nr2f2	nuclear receptor subfamily 2, group F, member 2	891	0.46
chr10_87500739_87501897	0.43	Gm48120	predicted gene, 48120	6544	0.19
chr9_72533965_72534704	0.43	Rfx7	regulatory factor X, 7	1599	0.21
chr16_38093809_38093980	0.43	Gsk3b	glycogen synthase kinase 3 beta	3606	0.27
chr16_74408614_74409150	0.43	Robo2	roundabout guidance receptor 2	2030	0.43
chr13_84905027_84905302	0.42	Gm4059	predicted gene 4059	69153	0.12
chr2_14740186_14740953	0.42	Gm10848	predicted gene 10848	847	0.36
chr16_28751716_28751977	0.42	Fgf12	fibroblast growth factor 12	1222	0.62
chr1_153665136_153666782	0.42	Rgs8	regulator of G-protein signaling 8	250	0.89
chrX_146965194_146965345	0.42	Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	2246	0.23
chr8_106985656_106985807	0.42	Gm22085	predicted gene, 22085	23880	0.1
chr8_108716860_108718878	0.41	Zfhx3	zinc finger homeobox 3	3225	0.3
chr2_73267880_73268204	0.41	Sp9	trans-acting transcription factor 9	3883	0.19
chr2_79047843_79048374	0.41	Gm14469	predicted gene 14469	9374	0.22
chrX_166344665_166345995	0.40	Gpm6b	glycoprotein m6b	488	0.85
chr17_45570526_45571346	0.40	Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	646	0.5
chr14_7821774_7821925	0.40	Flnb	filamin, beta	3892	0.19
chr4_103619552_103620735	0.39	Dab1	disabled 1	478	0.8
chr7_70363361_70364056	0.39	B130024G19Rik	RIKEN cDNA B130024G19 gene	1202	0.34
chr14_32601725_32601876	0.39	Prrxl1	paired related homeobox protein-like 1	1842	0.31
chr7_35949147_35949298	0.39	Gm28514	predicted gene 28514	110962	0.06
chr7_36703759_36704512	0.38	Tshz3	teashirt zinc finger family member 3	5918	0.14
chr3_80799469_80799764	0.38	Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	2963	0.34
chr15_102984578_102985289	0.38	Hoxc8	homeobox C8	5674	0.08
chr11_24085127_24085687	0.38	Bcl11a	B cell CLL/lymphoma 11A (zinc finger protein)	4737	0.16
chr2_158595089_158595667	0.38	Gm14204	predicted gene 14204	15212	0.11
chr7_70365047_70366578	0.38	B130024G19Rik	RIKEN cDNA B130024G19 gene	653	0.47
chr2_74695738_74695889	0.38	Gm14396	predicted gene 14396	212	0.75
chr3_31099281_31100546	0.37	Skil	SKI-like	3080	0.26
chr2_38341551_38341924	0.37	Lhx2	LIM homeobox protein 2	645	0.64
chr13_36728088_36728779	0.37	Gm30177	predicted gene, 30177	1175	0.4
chr15_99056560_99057587	0.37	Prph	peripherin	1103	0.3
chr3_7505053_7505454	0.37	Zc2hc1a	zinc finger, C2HC-type containing 1A	1767	0.33
chr17_91085493_91086001	0.37	Gm47307	predicted gene, 47307	2659	0.21
chr4_24429901_24430719	0.36	Gm27243	predicted gene 27243	580	0.79
chr14_61600038_61600691	0.36	Trim13	tripartite motif-containing 13	824	0.41
chrX_58027481_58028617	0.36	Zic3	zinc finger protein of the cerebellum 3	2594	0.35
chr14_122344326_122345026	0.36	Gm25464	predicted gene, 25464	43484	0.12
chr5_13125231_13126281	0.35	Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	163	0.95
chr16_77852573_77852735	0.35	Gm17333	predicted gene, 17333	6050	0.27
chr15_102593847_102594169	0.34	Atf7	activating transcription factor 7	30914	0.08
chr15_59876437_59876598	0.34	Gm7708	predicted gene 7708	53773	0.13
chr16_80017098_80017433	0.34	1700066C05Rik	RIKEN cDNA 1700066C05 gene	17889	0.27
chr13_63627159_63628101	0.34	Gm30709	predicted gene, 30709	251	0.9
chr7_124990750_124991105	0.34	Gm45093	predicted gene 45093	78564	0.09
chr5_118169234_118170295	0.34	Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	16	0.97
chr6_15196934_15197697	0.34	Foxp2	forkhead box P2	351	0.94
chr2_165367693_165368982	0.33	Zfp663	zinc finger protein 663	386	0.8
chr11_50222884_50223393	0.33	Mgat4b	mannoside acetylglucosaminyltransferase 4, isoenzyme B	2197	0.17
chr4_45824039_45824548	0.33	Igfbpl1	insulin-like growth factor binding protein-like 1	2630	0.22
chr10_127421987_127422298	0.33	R3hdm2	R3H domain containing 2	910	0.44
chr5_13127003_13127271	0.33	Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	1544	0.35
chr1_78172409_78172663	0.33	Pax3	paired box 3	24302	0.21
chr4_141734679_141735016	0.32	Ddi2	DNA-damage inducible protein 2	11428	0.12
chr14_24002097_24002465	0.32	4930519K11Rik	RIKEN cDNA 4930519K11 gene	1563	0.3
chr14_84450287_84451113	0.32	Pcdh17	protocadherin 17	2193	0.37
chr7_73554401_73554784	0.32	1810026B05Rik	RIKEN cDNA 1810026B05 gene	1328	0.3
chr7_73151898_73152049	0.32	4933435G04Rik	RIKEN cDNA 4933435G04 gene	27522	0.13
chr14_64594009_64594633	0.32	Mir3078	microRNA 3078	3136	0.2
chr12_109543555_109544268	0.32	Meg3	maternally expressed 3	587	0.28
chr1_12991432_12992703	0.32	Slco5a1	solute carrier organic anion transporter family, member 5A1	583	0.78
chr2_116074186_116074465	0.31	2810405F15Rik	RIKEN cDNA 2810405F15 gene	1771	0.31
chr6_101194590_101194876	0.31	Gm26911	predicted gene, 26911	3836	0.2
chr17_83792570_83792796	0.31	Mta3	metastasis associated 3	2739	0.29
chr7_137311015_137311991	0.30	Ebf3	early B cell factor 3	2413	0.29
chr15_36967150_36968398	0.30	Gm34590	predicted gene, 34590	28910	0.13
chr11_111522983_111523181	0.30	Gm11676	predicted gene 11676	90224	0.1
chr3_5212584_5213216	0.30	Gm10748	predicted gene 10748	62	0.97
chr11_60182522_60182943	0.30	Rai1	retinoic acid induced 1	6853	0.13
chr12_52435515_52435783	0.29	Gm47431	predicted gene, 47431	12476	0.21
chr5_120304073_120304707	0.29	Gm26474	predicted gene, 26474	16664	0.17
chr1_188065284_188065435	0.29	9330162B11Rik	RIKEN cDNA 9330162B11 gene	56369	0.14
chrX_64273727_64274331	0.28	Slitrk4	SLIT and NTRK-like family, member 4	1793	0.49
chrX_133682515_133683917	0.28	Pcdh19	protocadherin 19	1775	0.49
chr9_60798563_60798845	0.28	Uaca	uveal autoantigen with coiled-coil domains and ankyrin repeats	4079	0.22
chr17_51760240_51761547	0.28	C230085N15Rik	RIKEN cDNA C230085N15 gene	728	0.54
chr3_97763340_97765161	0.28	Pde4dip	phosphodiesterase 4D interacting protein (myomegalin)	3681	0.23
chr1_155414403_155414717	0.28	Xpr1	xenotropic and polytropic retrovirus receptor 1	2769	0.34
chr2_80126598_80127760	0.28	Pde1a	phosphodiesterase 1A, calmodulin-dependent	1655	0.42
chr12_27339427_27339967	0.28	Sox11	SRY (sex determining region Y)-box 11	2877	0.38
chr18_54125378_54126373	0.28	Gm8594	predicted gene 8594	94567	0.09
chr7_49907312_49908741	0.28	Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	2120	0.4
chrX_38473570_38474329	0.28	Gm7598	predicted gene 7598	2512	0.27
chr17_44810813_44811180	0.27	Runx2	runt related transcription factor 2	3230	0.26
chr14_61139006_61139387	0.27	Sacs	sacsin	705	0.73
chr14_72155158_72155309	0.27	Gm23735	predicted gene, 23735	24145	0.23
chr3_63961758_63962185	0.27	Gm26850	predicted gene, 26850	1662	0.26
chr7_87589934_87590085	0.27	Grm5	glutamate receptor, metabotropic 5	5611	0.31
chr2_28837901_28838652	0.27	Gtf3c4	general transcription factor IIIC, polypeptide 4	2010	0.23
chr9_79875436_79876355	0.26	Gm3211	predicted gene 3211	37305	0.12
chr19_57236960_57237217	0.26	Ablim1	actin-binding LIM protein 1	2241	0.34
chr5_127631930_127633243	0.26	Slc15a4	solute carrier family 15, member 4	294	0.51
chr3_34196316_34197672	0.26	Sox2ot	SOX2 overlapping transcript (non-protein coding)	130	0.97
chr5_137039973_137040124	0.26	Ap1s1	adaptor protein complex AP-1, sigma 1	2398	0.16
chr19_7384327_7384630	0.26	Spindoc	spindlin interactor and repressor of chromatin binding	1484	0.22
chr19_20010440_20010591	0.26	Gm22684	predicted gene, 22684	23120	0.22
chr7_61309034_61309202	0.26	A230006K03Rik	RIKEN cDNA A230006K03 gene	2595	0.4

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hlx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.3	0.8	GO:0097477	lateral motor column neuron migration(GO:0097477)
0.2	0.5	GO:1990123	L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.2	0.5	GO:1903375	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1	0.7	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.1	0.5	GO:0035934	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1	0.4	GO:0048880	sensory system development(GO:0048880)
0.1	0.9	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1	0.5	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.1	0.4	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1	2.3	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1	0.3	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1	0.3	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.1	0.5	GO:0072017	distal tubule development(GO:0072017)
0.1	0.2	GO:0015817	histidine transport(GO:0015817)
0.1	0.3	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
0.1	0.1	GO:0021550	medulla oblongata development(GO:0021550)
0.1	0.2	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1	0.3	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.1	0.8	GO:0097120	receptor localization to synapse(GO:0097120)
0.1	0.3	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1	0.2	GO:1903659	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1	0.4	GO:0042297	vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.1	0.4	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.1	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1	0.2	GO:0032512	regulation of protein phosphatase type 2B activity(GO:0032512)
0.1	0.1	GO:0007228	positive regulation of hh target transcription factor activity(GO:0007228)
0.1	0.4	GO:0042118	endothelial cell activation(GO:0042118)
0.1	0.2	GO:1904252	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1	0.4	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.8	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.1	GO:0045914	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:0010751	negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.5	GO:0001504	neurotransmitter uptake(GO:0001504)
0.0	0.2	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
0.0	0.2	GO:0021559	trigeminal nerve development(GO:0021559)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.4	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.1	GO:0097168	mesenchymal stem cell proliferation(GO:0097168)
0.0	0.1	GO:0003357	noradrenergic neuron differentiation(GO:0003357)
0.0	0.1	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.2	GO:0045199	maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0072051	juxtaglomerular apparatus development(GO:0072051)
0.0	0.2	GO:0021860	pyramidal neuron development(GO:0021860)
0.0	0.4	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
0.0	0.1	GO:1904304	regulation of gastro-intestinal system smooth muscle contraction(GO:1904304)
0.0	0.4	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.3	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.1	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.0	0.1	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.1	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.1	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.0	0.8	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	0.1	GO:0036233	glycine import(GO:0036233)
0.0	0.0	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.1	GO:0070366	regulation of hepatocyte differentiation(GO:0070366)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.7	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0	0.1	GO:0042723	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.0	GO:0072553	terminal button organization(GO:0072553)
0.0	0.1	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.1	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.0	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.6	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.0	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.0	GO:0061684	chaperone-mediated autophagy(GO:0061684)
0.0	0.1	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.0	0.0	GO:0034633	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0	0.0	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.5	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.0	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.3	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.0	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0061738	late endosomal microautophagy(GO:0061738)
0.0	0.3	GO:0072661	protein targeting to plasma membrane(GO:0072661)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.3	GO:2001258	negative regulation of cation channel activity(GO:2001258)
0.0	0.1	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.3	GO:2001222	regulation of neuron migration(GO:2001222)
0.0	0.0	GO:0021523	somatic motor neuron differentiation(GO:0021523)
0.0	0.0	GO:0072205	metanephric collecting duct development(GO:0072205)
0.0	0.0	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0	0.7	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.0	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.1	GO:1902222	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.0	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0086036	regulation of cardiac muscle cell membrane potential(GO:0086036)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.0	GO:0006570	tyrosine metabolic process(GO:0006570)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.0	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.0	GO:1902455	negative regulation of stem cell population maintenance(GO:1902455)
0.0	0.0	GO:2000599	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1	1.3	GO:0097449	astrocyte projection(GO:0097449)
0.1	0.2	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	0.5	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	0.2	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.3	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.3	GO:0032584	growth cone membrane(GO:0032584)
0.0	0.1	GO:0044299	C-fiber(GO:0044299)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.1	GO:1990716	axonemal central apparatus(GO:1990716)
0.0	0.8	GO:0031941	filamentous actin(GO:0031941)
0.0	0.6	GO:0032809	neuronal cell body membrane(GO:0032809)
0.0	0.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.1	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.1	GO:0044462	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:1990909	Wnt signalosome(GO:1990909)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.7	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	1.6	GO:0030426	growth cone(GO:0030426)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.2	2.3	GO:0050811	GABA receptor binding(GO:0050811)
0.1	0.8	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.5	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1	0.2	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.1	0.3	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.4	GO:0032051	clathrin light chain binding(GO:0032051)
0.1	0.3	GO:0005042	netrin receptor activity(GO:0005042)
0.1	0.3	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.1	0.3	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.1	0.2	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1	0.8	GO:0031005	filamin binding(GO:0031005)
0.1	0.2	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.4	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.9	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0051185	coenzyme transporter activity(GO:0051185)
0.0	0.5	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.4	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.2	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.1	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	1.0	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.4	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) glycine:sodium symporter activity(GO:0015375)
0.0	0.4	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.8	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.2	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.2	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.0	0.4	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.5	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.4	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.0	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.4	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.0	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.8	PID NETRIN PATHWAY	Netrin-mediated signaling events
1.3	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.3	PID REELIN PATHWAY	Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.6	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.2	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.5	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.1	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.4	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.1	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity