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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development
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Results for Hlx

Z-value: 0.59

Motif logo

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Transcription factors associated with Hlx

Gene Symbol Gene ID Gene Info
Hlx
ENSMUSG00000039377.6 H2.0-like homeobox

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_184733855_184734791Hlx17040.268399-0.612.9e-07Click!
chr1_184731287_184732512Hlx3010.862596-0.547.9e-06Click!
chr1_184732758_184733253Hlx3860.805138-0.496.2e-05Click!
chr1_184729496_184731200Hlx12500.373544-0.444.1e-04Click!
chr1_184728502_184729126Hlx27840.197330-0.437.1e-04Click!

Activity of the Hlx motif across conditions

Conditions sorted by the z-value of the Hlx motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr5_70842167_70842810 2.36 Gabrg1
 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
 129
 0.98
chr5_120426818_120428597 2.14 Lhx5
 LIM homeobox protein 5
 3992
 0.15
chr7_87586513_87587584 1.91 Grm5
 glutamate receptor, metabotropic 5
 2650
 0.4
chr18_43686213_43686392 1.88 Jakmip2
 janus kinase and microtubule interacting protein 2
 1323
 0.49
chr13_69734884_69735178 1.85 Ube2ql1
 ubiquitin-conjugating enzyme E2Q family-like 1
 4858
 0.14
chr14_66865047_66865736 1.83 Dpysl2
 dihydropyrimidinase-like 2
 3297
 0.19
chr3_8512495_8512918 1.63 Stmn2
 stathmin-like 2
 3120
 0.28
chr14_55056074_55056891 1.48 Gm20687
 predicted gene 20687
 989
 0.3
chr1_169745785_169746010 1.47 Rgs4
 regulator of G-protein signaling 4
 1726
 0.41
chr15_103058659_103059955 1.40 5730585A16Rik
 RIKEN cDNA 5730585A16 gene
 1
 0.95
chr9_52148115_52149635 1.36 Zc3h12c
 zinc finger CCCH type containing 12C
 19236
 0.18
chr8_34890130_34891317 1.19 Tnks
 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
 572
 0.8
chr18_59062200_59063436 1.19 Minar2
 membrane integral NOTCH2 associated receptor 2
 307
 0.94
chr3_38894285_38895428 1.11 Fat4
 FAT atypical cadherin 4
 3914
 0.27
chr3_89521563_89522618 1.08 Kcnn3
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
 1926
 0.28
chr3_63961199_63961587 1.08 Gm26850
 predicted gene, 26850
 2240
 0.21
chr18_54719777_54720132 1.07 Gm5821
 predicted gene 5821
 46178
 0.16
chr1_177448882_177449429 1.04 Zbtb18
 zinc finger and BTB domain containing 18
 3334
 0.19
chr18_25745414_25746450 1.00 Celf4
 CUGBP, Elav-like family member 4
 6760
 0.24
chr2_123533004_123533690 1.00 Gm13988
 predicted gene 13988
 259423
 0.02
chr9_41585694_41587243 0.97 Mir100hg
 Mir100 Mirlet7a-2 Mir125b-1 cluster host gene
 1301
 0.29
chr3_134236641_134237783 0.97 Cxxc4
 CXXC finger 4
 392
 0.78
chr7_123984527_123984925 0.96 Gm27040
 predicted gene, 27040
 1272
 0.38
chr3_86748624_86748824 0.93 Gm37876
 predicted gene, 37876
 29929
 0.17
chr7_137305711_137306880 0.92 Ebf3
 early B cell factor 3
 7621
 0.2
chr8_78433398_78433999 0.90 Pou4f2
 POU domain, class 4, transcription factor 2
 2947
 0.27
chr14_108912235_108913525 0.89 Slitrk1
 SLIT and NTRK-like family, member 1
 1278
 0.64
chr1_9296437_9296701 0.89 Sntg1
 syntrophin, gamma 1
 1667
 0.35
chr10_69536775_69537233 0.89 Ank3
 ankyrin 3, epithelial
 2782
 0.32
chr5_135248496_135249658 0.87 Fzd9
 frizzled class receptor 9
 2153
 0.21
chr11_32001099_32002296 0.87 Nsg2
 neuron specific gene family member 2
 1195
 0.52
chr2_146061763_146063020 0.86 Cfap61
 cilia and flagella associated protein 61
 15140
 0.25
chr2_151631540_151632560 0.85 Snph
 syntaphilin
 421
 0.78
chr1_115688015_115688174 0.85 Cntnap5a
 contactin associated protein-like 5A
 3338
 0.29
chr1_136228373_136230942 0.84 Inava
 innate immunity activator
 362
 0.76
chr13_104111586_104112312 0.81 Sgtb
 small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
 2120
 0.26
chr4_33926104_33927188 0.81 Cnr1
 cannabinoid receptor 1 (brain)
 444
 0.88
chr12_31711352_31711698 0.80 Gpr22
 G protein-coupled receptor 22
 2401
 0.25
chr5_37241461_37244349 0.78 Crmp1
 collapsin response mediator protein 1
 171
 0.95
chr19_44748114_44748265 0.78 Gm35610
 predicted gene, 35610
 6836
 0.15
chr7_79504311_79505700 0.78 Mir9-3
 microRNA 9-3
 259
 0.82
chr18_37217058_37218378 0.78 Gm10544
 predicted gene 10544
 39196
 0.08
chr6_112609185_112609336 0.76 Gm5578
 predicted pseudogene 5578
 3716
 0.21
chr7_99275133_99275418 0.76 Map6
 microtubule-associated protein 6
 6143
 0.13
chr19_20009817_20010437 0.75 Gm22684
 predicted gene, 22684
 23508
 0.22
chr13_83736071_83736534 0.75 Gm33366
 predicted gene, 33366
 2233
 0.18
chr11_23893045_23893724 0.74 Gm12061
 predicted gene 12061
 1176
 0.38
chr15_85682337_85682535 0.72 Lncppara
 long noncoding RNA near Ppara
 21337
 0.12
chr3_4796861_4798079 0.71 1110015O18Rik
 RIKEN cDNA 1110015O18 gene
 88
 0.98
chr12_79814152_79814328 0.71 9430078K24Rik
 RIKEN cDNA 9430078K24 gene
 110493
 0.06
chr2_163977230_163977381 0.71 Ywhab
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
 17655
 0.16
chr4_99659246_99659665 0.70 Gm23366
 predicted gene, 23366
 1713
 0.26
chr9_56159774_56159955 0.70 Tspan3
 tetraspanin 3
 678
 0.68
chr14_104641438_104641957 0.69 D130009I18Rik
 RIKEN cDNA D130009I18 gene
 2553
 0.3
chrX_6171274_6171425 0.69 Nudt10
 nudix (nucleoside diphosphate linked moiety X)-type motif 10
 1666
 0.4
chr12_117345149_117346019 0.67 Gm5441
 predicted gene 5441
 8562
 0.29
chr10_94941542_94941964 0.66 Plxnc1
 plexin C1
 3082
 0.28
chr11_96002027_96002959 0.66 Gm29202
 predicted gene 29202
 3396
 0.11
chr11_111605019_111605670 0.65 Gm11676
 predicted gene 11676
 7962
 0.32
chr13_20472048_20472724 0.64 Elmo1
 engulfment and cell motility 1
 340
 0.8
chr3_34654574_34655689 0.64 Sox2ot
 SOX2 overlapping transcript (non-protein coding)
 905
 0.42
chr19_12498310_12498475 0.64 Dtx4
 deltex 4, E3 ubiquitin ligase
 3062
 0.14
chr3_119154592_119155474 0.64 Gm43410
 predicted gene 43410
 286789
 0.01
chr14_104463807_104464161 0.64 Pou4f1
 POU domain, class 4, transcription factor 1
 1381
 0.4
chr1_19213854_19215338 0.63 Tfap2b
 transcription factor AP-2 beta
 717
 0.69
chr14_64233514_64233974 0.63 9630015K15Rik
 RIKEN cDNA 9630015K15 gene
 117430
 0.05
chr1_172341079_172341970 0.63 Kcnj10
 potassium inwardly-rectifying channel, subfamily J, member 10
 314
 0.81
chr6_7554855_7556232 0.62 Tac1
 tachykinin 1
 447
 0.85
chr12_46813712_46814094 0.62 Gm48542
 predicted gene, 48542
 2395
 0.29
chr19_47018258_47018719 0.60 Nt5c2
 5'-nucleotidase, cytosolic II
 3335
 0.15
chr7_51629095_51630495 0.58 Slc17a6
 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
 315
 0.88
chr2_65620767_65621991 0.57 Scn2a
 sodium channel, voltage-gated, type II, alpha
 568
 0.82
chr8_110275623_110275994 0.56 Gm26832
 predicted gene, 26832
 8346
 0.19
chr15_92598307_92599654 0.56 Pdzrn4
 PDZ domain containing RING finger 4
 1854
 0.49
chr9_74869680_74869831 0.55 Onecut1
 one cut domain, family member 1
 3271
 0.2
chr9_75681964_75682559 0.55 Scg3
 secretogranin III
 1326
 0.37
chr2_152080491_152081480 0.54 Scrt2
 scratch family zinc finger 2
 544
 0.7
chr5_63651264_63652181 0.54 Gm9954
 predicted gene 9954
 828
 0.61
chr1_15288505_15288656 0.53 Kcnb2
 potassium voltage gated channel, Shab-related subfamily, member 2
 1326
 0.51
chr8_41052368_41053980 0.53 Gm16193
 predicted gene 16193
 64
 0.96
chr14_122481884_122483266 0.53 Zic2
 zinc finger protein of the cerebellum 2
 4475
 0.12
chr2_116073034_116073185 0.52 2810405F15Rik
 RIKEN cDNA 2810405F15 gene
 2987
 0.22
chr18_72349127_72350542 0.52 Dcc
 deleted in colorectal carcinoma
 1183
 0.64
chr3_86543379_86544222 0.51 Lrba
 LPS-responsive beige-like anchor
 1767
 0.38
chr3_131341006_131341355 0.51 Sgms2
 sphingomyelin synthase 2
 3753
 0.2
chr10_89875205_89875398 0.50 Anks1b
 ankyrin repeat and sterile alpha motif domain containing 1B
 1629
 0.45
chr17_67499984_67500234 0.50 Gm36201
 predicted gene, 36201
 129223
 0.05
chr12_52700044_52701597 0.50 Akap6
 A kinase (PRKA) anchor protein 6
 1437
 0.46
chr15_18819282_18819740 0.50 Cdh10
 cadherin 10
 534
 0.58
chr7_35848412_35848964 0.49 Gm28514
 predicted gene 28514
 10428
 0.21
chr11_96593909_96594964 0.48 Skap1
 src family associated phosphoprotein 1
 104575
 0.05
chr4_128885478_128885629 0.48 Trim62
 tripartite motif-containing 62
 1965
 0.27
chr10_90578974_90579573 0.48 Anks1b
 ankyrin repeat and sterile alpha motif domain containing 1B
 2281
 0.42
chr10_90577565_90578158 0.47 Anks1b
 ankyrin repeat and sterile alpha motif domain containing 1B
 869
 0.72
chrX_153501207_153502250 0.47 Ubqln2
 ubiquilin 2
 3501
 0.22
chr2_72426765_72427714 0.47 Cdca7
 cell division cycle associated 7
 48920
 0.13
chr8_47345612_47345906 0.46 Stox2
 storkhead box 2
 6589
 0.26
chr11_84520959_84524590 0.46 Lhx1
 LIM homeobox protein 1
 63
 0.97
chr18_42429204_42429681 0.46 Gm16415
 predicted pseudogene 16415
 11577
 0.18
chr4_124254790_124255065 0.46 Gm37667
 predicted gene, 37667
 24250
 0.16
chr9_91404809_91406365 0.45 Gm29478
 predicted gene 29478
 1113
 0.42
chr17_56241459_56242409 0.45 A230051N06Rik
 RIKEN cDNA A230051N06 gene
 218
 0.81
chr10_45889498_45890055 0.44 Gpx4-ps2
 glutathione peroxidase 4, pseudogene 2
 14471
 0.23
chr7_70355803_70356454 0.43 Nr2f2
 nuclear receptor subfamily 2, group F, member 2
 891
 0.46
chr10_87500739_87501897 0.43 Gm48120
 predicted gene, 48120
 6544
 0.19
chr9_72533965_72534704 0.43 Rfx7
 regulatory factor X, 7
 1599
 0.21
chr16_38093809_38093980 0.43 Gsk3b
 glycogen synthase kinase 3 beta
 3606
 0.27
chr16_74408614_74409150 0.43 Robo2
 roundabout guidance receptor 2
 2030
 0.43
chr13_84905027_84905302 0.42 Gm4059
 predicted gene 4059
 69153
 0.12
chr2_14740186_14740953 0.42 Gm10848
 predicted gene 10848
 847
 0.36
chr16_28751716_28751977 0.42 Fgf12
 fibroblast growth factor 12
 1222
 0.62
chr1_153665136_153666782 0.42 Rgs8
 regulator of G-protein signaling 8
 250
 0.89
chrX_146965194_146965345 0.42 Htr2c
 5-hydroxytryptamine (serotonin) receptor 2C
 2246
 0.23
chr8_106985656_106985807 0.42 Gm22085
 predicted gene, 22085
 23880
 0.1
chr8_108716860_108718878 0.41 Zfhx3
 zinc finger homeobox 3
 3225
 0.3
chr2_73267880_73268204 0.41 Sp9
 trans-acting transcription factor 9
 3883
 0.19
chr2_79047843_79048374 0.41 Gm14469
 predicted gene 14469
 9374
 0.22
chrX_166344665_166345995 0.40 Gpm6b
 glycoprotein m6b
 488
 0.85
chr17_45570526_45571346 0.40 Hsp90ab1
 heat shock protein 90 alpha (cytosolic), class B member 1
 646
 0.5
chr14_7821774_7821925 0.40 Flnb
 filamin, beta
 3892
 0.19
chr4_103619552_103620735 0.39 Dab1
 disabled 1
 478
 0.8
chr7_70363361_70364056 0.39 B130024G19Rik
 RIKEN cDNA B130024G19 gene
 1202
 0.34
chr14_32601725_32601876 0.39 Prrxl1
 paired related homeobox protein-like 1
 1842
 0.31
chr7_35949147_35949298 0.39 Gm28514
 predicted gene 28514
 110962
 0.06
chr7_36703759_36704512 0.38 Tshz3
 teashirt zinc finger family member 3
 5918
 0.14
chr3_80799469_80799764 0.38 Gria2
 glutamate receptor, ionotropic, AMPA2 (alpha 2)
 2963
 0.34
chr15_102984578_102985289 0.38 Hoxc8
 homeobox C8
 5674
 0.08
chr11_24085127_24085687 0.38 Bcl11a
 B cell CLL/lymphoma 11A (zinc finger protein)
 4737
 0.16
chr2_158595089_158595667 0.38 Gm14204
 predicted gene 14204
 15212
 0.11
chr7_70365047_70366578 0.38 B130024G19Rik
 RIKEN cDNA B130024G19 gene
 653
 0.47
chr2_74695738_74695889 0.38 Gm14396
 predicted gene 14396
 212
 0.75
chr3_31099281_31100546 0.37 Skil
 SKI-like
 3080
 0.26
chr2_38341551_38341924 0.37 Lhx2
 LIM homeobox protein 2
 645
 0.64
chr13_36728088_36728779 0.37 Gm30177
 predicted gene, 30177
 1175
 0.4
chr15_99056560_99057587 0.37 Prph
 peripherin
 1103
 0.3
chr3_7505053_7505454 0.37 Zc2hc1a
 zinc finger, C2HC-type containing 1A
 1767
 0.33
chr17_91085493_91086001 0.37 Gm47307
 predicted gene, 47307
 2659
 0.21
chr4_24429901_24430719 0.36 Gm27243
 predicted gene 27243
 580
 0.79
chr14_61600038_61600691 0.36 Trim13
 tripartite motif-containing 13
 824
 0.41
chrX_58027481_58028617 0.36 Zic3
 zinc finger protein of the cerebellum 3
 2594
 0.35
chr14_122344326_122345026 0.36 Gm25464
 predicted gene, 25464
 43484
 0.12
chr5_13125231_13126281 0.35 Sema3a
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 163
 0.95
chr16_77852573_77852735 0.35 Gm17333
 predicted gene, 17333
 6050
 0.27
chr15_102593847_102594169 0.34 Atf7
 activating transcription factor 7
 30914
 0.08
chr15_59876437_59876598 0.34 Gm7708
 predicted gene 7708
 53773
 0.13
chr16_80017098_80017433 0.34 1700066C05Rik
 RIKEN cDNA 1700066C05 gene
 17889
 0.27
chr13_63627159_63628101 0.34 Gm30709
 predicted gene, 30709
 251
 0.9
chr7_124990750_124991105 0.34 Gm45093
 predicted gene 45093
 78564
 0.09
chr5_118169234_118170295 0.34 Hrk
 harakiri, BCL2 interacting protein (contains only BH3 domain)
 16
 0.97
chr6_15196934_15197697 0.34 Foxp2
 forkhead box P2
 351
 0.94
chr2_165367693_165368982 0.33 Zfp663
 zinc finger protein 663
 386
 0.8
chr11_50222884_50223393 0.33 Mgat4b
 mannoside acetylglucosaminyltransferase 4, isoenzyme B
 2197
 0.17
chr4_45824039_45824548 0.33 Igfbpl1
 insulin-like growth factor binding protein-like 1
 2630
 0.22
chr10_127421987_127422298 0.33 R3hdm2
 R3H domain containing 2
 910
 0.44
chr5_13127003_13127271 0.33 Sema3a
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 1544
 0.35
chr1_78172409_78172663 0.33 Pax3
 paired box 3
 24302
 0.21
chr4_141734679_141735016 0.32 Ddi2
 DNA-damage inducible protein 2
 11428
 0.12
chr14_24002097_24002465 0.32 4930519K11Rik
 RIKEN cDNA 4930519K11 gene
 1563
 0.3
chr14_84450287_84451113 0.32 Pcdh17
 protocadherin 17
 2193
 0.37
chr7_73554401_73554784 0.32 1810026B05Rik
 RIKEN cDNA 1810026B05 gene
 1328
 0.3
chr7_73151898_73152049 0.32 4933435G04Rik
 RIKEN cDNA 4933435G04 gene
 27522
 0.13
chr14_64594009_64594633 0.32 Mir3078
 microRNA 3078
 3136
 0.2
chr12_109543555_109544268 0.32 Meg3
 maternally expressed 3
 587
 0.28
chr1_12991432_12992703 0.32 Slco5a1
 solute carrier organic anion transporter family, member 5A1
 583
 0.78
chr2_116074186_116074465 0.31 2810405F15Rik
 RIKEN cDNA 2810405F15 gene
 1771
 0.31
chr6_101194590_101194876 0.31 Gm26911
 predicted gene, 26911
 3836
 0.2
chr17_83792570_83792796 0.31 Mta3
 metastasis associated 3
 2739
 0.29
chr7_137311015_137311991 0.30 Ebf3
 early B cell factor 3
 2413
 0.29
chr15_36967150_36968398 0.30 Gm34590
 predicted gene, 34590
 28910
 0.13
chr11_111522983_111523181 0.30 Gm11676
 predicted gene 11676
 90224
 0.1
chr3_5212584_5213216 0.30 Gm10748
 predicted gene 10748
 62
 0.97
chr11_60182522_60182943 0.30 Rai1
 retinoic acid induced 1
 6853
 0.13
chr12_52435515_52435783 0.29 Gm47431
 predicted gene, 47431
 12476
 0.21
chr5_120304073_120304707 0.29 Gm26474
 predicted gene, 26474
 16664
 0.17
chr1_188065284_188065435 0.29 9330162B11Rik
 RIKEN cDNA 9330162B11 gene
 56369
 0.14
chrX_64273727_64274331 0.28 Slitrk4
 SLIT and NTRK-like family, member 4
 1793
 0.49
chrX_133682515_133683917 0.28 Pcdh19
 protocadherin 19
 1775
 0.49
chr9_60798563_60798845 0.28 Uaca
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 4079
 0.22
chr17_51760240_51761547 0.28 C230085N15Rik
 RIKEN cDNA C230085N15 gene
 728
 0.54
chr3_97763340_97765161 0.28 Pde4dip
 phosphodiesterase 4D interacting protein (myomegalin)
 3681
 0.23
chr1_155414403_155414717 0.28 Xpr1
 xenotropic and polytropic retrovirus receptor 1
 2769
 0.34
chr2_80126598_80127760 0.28 Pde1a
 phosphodiesterase 1A, calmodulin-dependent
 1655
 0.42
chr12_27339427_27339967 0.28 Sox11
 SRY (sex determining region Y)-box 11
 2877
 0.38
chr18_54125378_54126373 0.28 Gm8594
 predicted gene 8594
 94567
 0.09
chr7_49907312_49908741 0.28 Slc6a5
 solute carrier family 6 (neurotransmitter transporter, glycine), member 5
 2120
 0.4
chrX_38473570_38474329 0.28 Gm7598
 predicted gene 7598
 2512
 0.27
chr17_44810813_44811180 0.27 Runx2
 runt related transcription factor 2
 3230
 0.26
chr14_61139006_61139387 0.27 Sacs
 sacsin
 705
 0.73
chr14_72155158_72155309 0.27 Gm23735
 predicted gene, 23735
 24145
 0.23
chr3_63961758_63962185 0.27 Gm26850
 predicted gene, 26850
 1662
 0.26
chr7_87589934_87590085 0.27 Grm5
 glutamate receptor, metabotropic 5
 5611
 0.31
chr2_28837901_28838652 0.27 Gtf3c4
 general transcription factor IIIC, polypeptide 4
 2010
 0.23
chr9_79875436_79876355 0.26 Gm3211
 predicted gene 3211
 37305
 0.12
chr19_57236960_57237217 0.26 Ablim1
 actin-binding LIM protein 1
 2241
 0.34
chr5_127631930_127633243 0.26 Slc15a4
 solute carrier family 15, member 4
 294
 0.51
chr3_34196316_34197672 0.26 Sox2ot
 SOX2 overlapping transcript (non-protein coding)
 130
 0.97
chr5_137039973_137040124 0.26 Ap1s1
 adaptor protein complex AP-1, sigma 1
 2398
 0.16
chr19_7384327_7384630 0.26 Spindoc
 spindlin interactor and repressor of chromatin binding
 1484
 0.22
chr19_20010440_20010591 0.26 Gm22684
 predicted gene, 22684
 23120
 0.22
chr7_61309034_61309202 0.26 A230006K03Rik
 RIKEN cDNA A230006K03 gene
 2595
 0.4

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Hlx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.3 0.8 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.2 0.5 GO:1990123 L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.2 0.5 GO:1903375 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 0.7 GO:0031999 negative regulation of fatty acid beta-oxidation(GO:0031999)
0.1 0.5 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 0.4 GO:0048880 sensory system development(GO:0048880)
0.1 0.9 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.5 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 2.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.3 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.5 GO:0072017 distal tubule development(GO:0072017)
0.1 0.2 GO:0015817 histidine transport(GO:0015817)
0.1 0.3 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 0.1 GO:0021550 medulla oblongata development(GO:0021550)
0.1 0.2 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1 0.3 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.1 0.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 0.3 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 0.2 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.4 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.1 0.4 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.1 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1 0.2 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512)
0.1 0.1 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 0.4 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.2 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 0.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.8 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.1 GO:0045914 negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0 0.1 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.1 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.0 0.1 GO:0060300 regulation of cytokine activity(GO:0060300)
0.0 0.1 GO:2000828 regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.5 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:0021559 trigeminal nerve development(GO:0021559)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0060916 mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0 0.4 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.1 GO:0097168 mesenchymal stem cell proliferation(GO:0097168)
0.0 0.1 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0 0.2 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0072051 juxtaglomerular apparatus development(GO:0072051)
0.0 0.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.1 GO:1904304 regulation of gastro-intestinal system smooth muscle contraction(GO:1904304)
0.0 0.4 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.3 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.8 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.1 GO:0036233 glycine import(GO:0036233)
0.0 0.0 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.1 GO:0042723 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.0 GO:0072553 terminal button organization(GO:0072553)
0.0 0.1 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.0 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.6 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.0 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.0 GO:0061684 chaperone-mediated autophagy(GO:0061684)
0.0 0.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.0 GO:0034633 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0 0.0 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.0 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.0 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.0 GO:0061738 late endosomal microautophagy(GO:0061738)
0.0 0.3 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.3 GO:2001258 negative regulation of cation channel activity(GO:2001258)
0.0 0.1 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.0 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.0 0.0 GO:0072205 metanephric collecting duct development(GO:0072205)
0.0 0.0 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.0 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:1902222 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 0.0 GO:1900045 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0086036 regulation of cardiac muscle cell membrane potential(GO:0086036)
0.0 0.1 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.0 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.0 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0015816 glycine transport(GO:0015816)
0.0 0.0 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.0 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.0 GO:2000599 regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.3 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0044299 C-fiber(GO:0044299)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 0.1 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0044462 cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 1.6 GO:0030426 growth cone(GO:0030426)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0008278 cohesin complex(GO:0008278)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0071001 U4/U6 snRNP(GO:0071001)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.2 2.3 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.8 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 0.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.2 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 0.3 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.1 0.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.3 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.1 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.8 GO:0031005 filamin binding(GO:0031005)
0.1 0.2 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.1 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.4 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) glycine:sodium symporter activity(GO:0015375)
0.0 0.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.4 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.0 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0 0.0 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.1 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity