Project

ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hoxa3

Z-value: 0.36

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Transcription factors associated with Hoxa3

Gene Symbol	Gene ID	Gene Info
Hoxa3 Ensembl NCBI MGI UniProt	ENSMUSG00000079560.7	Hoxa3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hoxa3	chr6_52211753_52213405	536	0.359745	0.14	3.0e-01	Click!
Hoxa3	chr6_52185807_52185988	1023	0.205032	-0.12	3.6e-01	Click!
Hoxa3	chr6_52187599_52188482	3166	0.068417	0.09	5.1e-01	Click!
Hoxa3	chr6_52211085_52211739	1703	0.105183	0.08	5.4e-01	Click!
Hoxa3	chr6_52187293_52187465	2505	0.080085	-0.08	5.7e-01	Click!

Activity of the Hoxa3 motif across conditions

Conditions sorted by the z-value of the Hoxa3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_33083500_33083959	0.94	Trdn	triadin	168	0.97
chr6_146500226_146500471	0.67	Itpr2	inositol 1,4,5-triphosphate receptor 2	1530	0.4
chr8_57317953_57318771	0.58	Hand2os1	Hand2, opposite strand 1	462	0.73
chr2_20942943_20943436	0.54	Arhgap21	Rho GTPase activating protein 21	230	0.93
chr12_117200442_117200898	0.51	Gm10421	predicted gene 10421	49019	0.16
chrX_142684293_142684706	0.47	Tmem164	transmembrane protein 164	1611	0.4
chr14_63249784_63250324	0.46	Gata4	GATA binding protein 4	4783	0.2
chr5_148990792_148991310	0.45	Gm42791	predicted gene 42791	4096	0.1
chr13_44167401_44167573	0.44	Gm33684	predicted gene, 33684	16892	0.17
chr5_116456914_116457389	0.42	Gm42853	predicted gene 42853	333	0.83
chr10_45338438_45338763	0.41	Bves	blood vessel epicardial substance	2828	0.24
chr2_79087179_79088090	0.39	Gm14469	predicted gene 14469	48900	0.14
chr8_61901693_61901844	0.37	Palld	palladin, cytoskeletal associated protein	901	0.56
chr5_138609015_138609166	0.37	Gm15497	predicted gene 15497	1649	0.2
chr11_65269494_65270784	0.37	Myocd	myocardin	150	0.96
chr5_143293458_143294037	0.37	Zfp853	zinc finger protein 853	124	0.91
chr11_65266805_65267363	0.36	Myocd	myocardin	2770	0.29
chr3_155052033_155052416	0.36	Tnni3k	TNNI3 interacting kinase	3126	0.26
chr13_46424530_46424922	0.36	Rbm24	RNA binding motif protein 24	2904	0.31
chr7_29819755_29819906	0.35	Zfp790	zinc finger protein 790	839	0.4
chr12_51594696_51594847	0.35	Coch	cochlin	1392	0.48
chr10_39165752_39166209	0.34	Ccn6	cellular communication network factor 6	2186	0.23
chr10_108944251_108944402	0.33	Gm47477	predicted gene, 47477	12162	0.27
chr15_81873813_81874521	0.33	Aco2	aconitase 2, mitochondrial	1477	0.21
chrX_138915472_138915880	0.33	Nrk	Nik related kinase	1245	0.61
chr4_87359673_87359861	0.32	Gm12600	predicted gene 12600	61405	0.13
chr2_63982565_63982778	0.32	Fign	fidgetin	115317	0.07
chr13_41486298_41486655	0.31	Gm32401	predicted gene, 32401	654	0.45
chr2_48417232_48417383	0.31	Gm13472	predicted gene 13472	29270	0.17
chrX_85775362_85775513	0.30	Gk	glycerol kinase	1187	0.39
chrX_146946268_146946419	0.30	Gm4996	predicted gene 4996	13658	0.15
chr18_25694097_25694278	0.30	0710001A04Rik	RIKEN cDNA 0710001A04 gene	19583	0.23
chr10_95297621_95297998	0.30	Gm48880	predicted gene, 48880	17044	0.14
chrX_53267645_53268215	0.30	Fam122b	family with sequence similarity 122, member B	1090	0.45
chr8_30958732_30959710	0.30	Gm45252	predicted gene 45252	44687	0.18
chr16_44015370_44016774	0.28	Gramd1c	GRAM domain containing 1C	364	0.83
chr7_44472607_44472821	0.28	5430431A17Rik	RIKEN cDNA 5430431A17 gene	824	0.31
chr14_32684282_32684433	0.28	3425401B19Rik	RIKEN cDNA 3425401B19 gene	915	0.46
chr2_172937060_172938226	0.28	Bmp7	bone morphogenetic protein 7	2449	0.28
chr18_4636274_4636995	0.28	Jcad	junctional cadherin 5 associated	1756	0.43
chr1_177199086_177199237	0.28	Gm37706	predicted gene, 37706	28299	0.14
chr5_24350563_24350755	0.27	Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	945	0.38
chr1_46970388_46970697	0.26	Gm28527	predicted gene 28527	73663	0.09
chr14_65374778_65375936	0.26	Zfp395	zinc finger protein 395	36	0.97
chr5_27264978_27265420	0.25	Dpp6	dipeptidylpeptidase 6	3224	0.31
chr14_46491764_46491915	0.25	Gm34756	predicted gene, 34756	10611	0.12
chr1_140182332_140182724	0.25	Cfh	complement component factor h	752	0.73
chr6_117605384_117605669	0.25	Gm45083	predicted gene 45083	7044	0.22
chr12_112590746_112590946	0.24	Inf2	inverted formin, FH2 and WH2 domain containing	1580	0.31
chr2_152436557_152436921	0.24	6820408C15Rik	RIKEN cDNA 6820408C15 gene	9077	0.08
chr10_72299004_72299155	0.24	Gm9923	predicted pseudogene 9923	10242	0.31
chr1_186515830_186515981	0.24	A730004F24Rik	RIKEN cDNA A730004F24 gene	42567	0.18
chr16_96205810_96206739	0.24	Sh3bgr	SH3-binding domain glutamic acid-rich protein	369	0.83
chr15_40661942_40662224	0.24	Zfpm2	zinc finger protein, multitype 2	2907	0.38
chr9_86438288_86439112	0.23	Ube2cbp	ubiquitin-conjugating enzyme E2C binding protein	26250	0.17
chr1_89991921_89993000	0.23	Asb18	ankyrin repeat and SOCS box-containing 18	3992	0.25
chr13_45571916_45572112	0.23	Gmpr	guanosine monophosphate reductase	25861	0.23
chr11_117482269_117483090	0.22	Gm34418	predicted gene, 34418	82	0.95
chr4_105100875_105101089	0.22	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	8908	0.27
chr4_32486662_32487238	0.22	Bach2	BTB and CNC homology, basic leucine zipper transcription factor 2	14555	0.23
chr16_72699332_72699617	0.22	Robo1	roundabout guidance receptor 1	36270	0.24
chr8_109417937_109418404	0.22	Gm23163	predicted gene, 23163	7574	0.24
chr9_77919114_77919265	0.22	Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	1755	0.29
chr10_33091664_33091948	0.22	Trdn	triadin	8245	0.26
chr5_52806998_52807149	0.21	Zcchc4	zinc finger, CCHC domain containing 4	2747	0.27
chr14_46202990_46203141	0.21	Ubb-ps	ubiquitin B, pseudogene	118937	0.05
chr5_138608490_138608879	0.21	Zfp68	zinc finger protein 68	1627	0.2
chr10_60826340_60827679	0.21	Unc5b	unc-5 netrin receptor B	4373	0.21
chr7_136007847_136008710	0.21	Gm9341	predicted gene 9341	55480	0.13
chr2_94404907_94405280	0.21	Ttc17	tetratricopeptide repeat domain 17	102	0.94
chr13_71961770_71962476	0.21	Irx1	Iroquois homeobox 1	1407	0.5
chr9_79976568_79977294	0.21	Filip1	filamin A interacting protein 1	728	0.66
chr9_47650354_47650592	0.21	Cadm1	cell adhesion molecule 1	120100	0.05
chr8_85427729_85428024	0.20	1700051O22Rik	RIKEN cDNA 1700051O22 Gene	4810	0.15
chr19_44631481_44631730	0.20	Gm35460	predicted gene, 35460	16840	0.15
chr1_77708269_77708811	0.20	Gm28385	predicted gene 28385	137868	0.05
chr14_27237814_27239092	0.20	Gm49616	predicted gene, 49616	391	0.49
chr11_52166541_52167570	0.20	Olfr1372-ps1	olfactory receptor 1372, pseudogene 1	1104	0.37
chr4_116073957_116074118	0.19	Uqcrh	ubiquinol-cytochrome c reductase hinge protein	994	0.31
chr4_5724213_5725550	0.19	Fam110b	family with sequence similarity 110, member B	569	0.81
chr18_56683771_56684023	0.19	Gm50289	predicted gene, 50289	16119	0.16
chr7_136275874_136276030	0.19	C030029H02Rik	RIKEN cDNA C030029H02 gene	7618	0.21
chr6_88041235_88041766	0.19	Gm44187	predicted gene, 44187	967	0.4
chr16_4448299_4448450	0.19	Adcy9	adenylate cyclase 9	27876	0.16
chr15_11741805_11742688	0.19	Gm41271	predicted gene, 41271	38543	0.18
chr10_45048086_45048775	0.18	Prep	prolyl endopeptidase	18773	0.15
chr11_88617275_88617426	0.18	Msi2	musashi RNA-binding protein 2	27203	0.2
chr14_79645123_79645681	0.18	Cnmd	chondromodulin	108	0.96
chr1_72226384_72226568	0.18	Gm25360	predicted gene, 25360	236	0.89
chr5_137348685_137349851	0.18	Ephb4	Eph receptor B4	841	0.39
chr3_8684903_8685755	0.18	Gm23670	predicted gene, 23670	5852	0.16
chr9_98964920_98965344	0.18	Foxl2os	forkhead box L2, opposite strand	9833	0.12
chr14_54362334_54362485	0.17	Oxa1l	oxidase assembly 1-like	1364	0.25
chr10_117044417_117044727	0.17	Lrrc10	leucine rich repeat containing 10	769	0.38
chr17_71290536_71290920	0.17	Emilin2	elastin microfibril interfacer 2	6519	0.15
chr8_90176316_90176467	0.17	Tox3	TOX high mobility group box family member 3	171735	0.04
chr11_117505657_117505808	0.17	Gm11734	predicted gene 11734	17871	0.14
chr8_92361507_92362918	0.17	Irx5	Iroquois homeobox 5	4463	0.2
chr3_148983311_148983462	0.17	Gm43573	predicted gene 43573	5766	0.19
chr3_126599850_126600378	0.17	Gm43011	predicted gene 43011	85	0.96
chr8_80853437_80854023	0.16	Gab1	growth factor receptor bound protein 2-associated protein 1	22846	0.16
chr3_65832584_65832735	0.16	Gm37131	predicted gene, 37131	32170	0.13
chr9_103364095_103364246	0.16	Cdv3	carnitine deficiency-associated gene expressed in ventricle 3	727	0.6
chr8_27263249_27263470	0.16	Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1	1055	0.37
chr3_66976156_66976605	0.16	Shox2	short stature homeobox 2	2067	0.29
chr13_110396048_110396669	0.16	Plk2	polo like kinase 2	346	0.91
chr1_32176216_32176451	0.16	Khdrbs2	KH domain containing, RNA binding, signal transduction associated 2	3446	0.32
chr13_89547281_89547432	0.16	Hapln1	hyaluronan and proteoglycan link protein 1	7560	0.25
chr10_120128769_120129086	0.16	Helb	helicase (DNA) B	15940	0.17
chr2_64092860_64093848	0.16	Fign	fidgetin	4634	0.37
chr7_50588908_50589191	0.16	4933405O20Rik	RIKEN cDNA 4933405O20 gene	10141	0.24
chr6_144419028_144419519	0.16	Sox5os2	SRY (sex determining region Y)-box 5, opposite strand 2	61952	0.15
chr14_119831360_119832142	0.16	4930404K13Rik	RIKEN cDNA 4930404K13 gene	32773	0.18
chr14_119602272_119602445	0.15	Gm6212	predicted gene 6212	41654	0.2
chr19_45223479_45224523	0.15	Lbx1	ladybird homeobox 1	11811	0.18
chr13_9494460_9495468	0.15	Gm48871	predicted gene, 48871	49064	0.12
chr3_70104094_70104909	0.15	Gm37585	predicted gene, 37585	12031	0.22
chr3_87630903_87631116	0.15	Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	12248	0.16
chr19_45235899_45236901	0.15	Lbx1	ladybird homeobox 1	588	0.75
chr2_101652616_101653044	0.15	B230118H07Rik	RIKEN cDNA B230118H07 gene	3298	0.2
chr9_28056769_28056920	0.15	Gm15606	predicted gene 15606	141043	0.05
chr3_55782023_55782190	0.15	Mab21l1	mab-21-like 1	404	0.8
chr6_45096373_45096524	0.15	Gm43879	predicted gene, 43879	15702	0.16
chr5_103972357_103973054	0.15	Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	4621	0.16
chr14_20696186_20696337	0.15	Fut11	fucosyltransferase 11	1284	0.22
chr6_97457802_97459465	0.15	Frmd4b	FERM domain containing 4B	653	0.74
chr13_115098735_115099036	0.15	Gm49395	predicted gene, 49395	2739	0.18
chr4_44083540_44083707	0.15	Gne	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	300	0.84
chr10_37988715_37989307	0.14	Gm24710	predicted gene, 24710	57331	0.15
chr16_4519120_4519560	0.14	Srl	sarcalumenin	3723	0.19
chr9_65162369_65163541	0.14	Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	17783	0.12
chr19_29271229_29271592	0.14	Jak2	Janus kinase 2	18969	0.16
chr5_105052746_105052954	0.14	Gbp8	guanylate-binding protein 8	706	0.66
chr1_136868933_136869351	0.14	Gm17781	predicted gene, 17781	70183	0.08
chr8_119365249_119365400	0.14	Gm45723	predicted gene 45723	13372	0.16
chr8_34079766_34081014	0.14	Dctn6	dynactin 6	12535	0.12
chr8_57799694_57800553	0.14	Galntl6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	3533	0.27
chr10_121504972_121505664	0.14	Gm46204	predicted gene, 46204	33	0.95
chr18_35844890_35845340	0.14	Cxxc5	CXXC finger 5	9572	0.1
chr6_91980058_91980209	0.14	Fgd5	FYVE, RhoGEF and PH domain containing 5	1255	0.39
chr11_19012477_19012923	0.14	Meis1	Meis homeobox 1	698	0.49
chr15_50870065_50870337	0.14	Trps1	transcriptional repressor GATA binding 1	12605	0.21
chr1_161494611_161494762	0.13	Tnfsf18	tumor necrosis factor (ligand) superfamily, member 18	31	0.98
chr1_81593421_81594539	0.13	Gm6198	predicted gene 6198	36497	0.2
chr12_9253584_9253735	0.13	Gm46323	predicted gene, 46323	117779	0.06
chr2_172448714_172448865	0.13	Rtf2	replication termination factor 2	4188	0.15
chr13_30724955_30725406	0.13	Gm11370	predicted gene 11370	6597	0.21
chr3_63899898_63900049	0.13	Plch1	phospholipase C, eta 1	501	0.73
chr9_79977295_79978179	0.13	Filip1	filamin A interacting protein 1	67	0.97
chr13_73262153_73264451	0.13	Irx4	Iroquois homeobox 4	2805	0.22
chr11_64656679_64656830	0.13	Gm24275	predicted gene, 24275	66114	0.13
chr12_107010953_107011720	0.13	Gm16087	predicted gene 16087	55408	0.13
chr1_155526845_155527426	0.13	Gm5532	predicted gene 5532	8	0.98
chr6_148598605_148599513	0.13	Gm6313	predicted gene 6313	10674	0.2
chr8_34890130_34891317	0.13	Tnks	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	572	0.8
chr4_147131860_147132011	0.13	Zfp991	zinc finger protein 991	103	0.94
chr13_109262801_109262952	0.13	Pde4d	phosphodiesterase 4D, cAMP specific	2222	0.44
chr8_109250884_109251908	0.13	D030068K23Rik	RIKEN cDNA D030068K23 gene	1530	0.52
chr6_98525524_98525718	0.12	4930595L18Rik	RIKEN cDNA 4930595L18 gene	26486	0.26
chr11_76334808_76334959	0.12	Nxn	nucleoredoxin	64185	0.09
chr2_145233751_145234233	0.12	Slc24a3	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	8619	0.29
chr2_167713707_167713858	0.12	A530013C23Rik	RIKEN cDNA A530013C23 gene	22601	0.11
chr8_94152224_94153713	0.12	Mt3	metallothionein 3	222	0.87
chr10_69690251_69691139	0.12	Ank3	ankyrin 3, epithelial	15601	0.28
chr9_60742965_60743393	0.12	1700036A12Rik	RIKEN cDNA 1700036A12 gene	59	0.97
chr12_98577628_98578516	0.12	Kcnk10	potassium channel, subfamily K, member 10	238	0.9
chr11_96341535_96342715	0.12	Gm11536	predicted gene 11536	17	0.92
chr2_84455336_84455529	0.12	Tfpi	tissue factor pathway inhibitor	2678	0.26
chr3_88509652_88510583	0.12	Lmna	lamin A	161	0.88
chr8_61895218_61895438	0.12	Palld	palladin, cytoskeletal associated protein	7341	0.18
chr4_40851422_40852119	0.12	Gm25931	predicted gene, 25931	1368	0.21
chr10_68191368_68192460	0.12	Arid5b	AT rich interactive domain 5B (MRF1-like)	55288	0.14
chr19_45228695_45230660	0.12	Lbx1	ladybird homeobox 1	6135	0.2
chr3_155054773_155054924	0.12	Tnni3k	TNNI3 interacting kinase	502	0.8
chr6_50358058_50358744	0.12	Osbpl3	oxysterol binding protein-like 3	6444	0.27
chr11_75291523_75292140	0.12	Gm47300	predicted gene, 47300	26777	0.12
chr8_110321934_110322150	0.12	Gm26832	predicted gene, 26832	54580	0.11
chr8_48596222_48596652	0.11	Gm45772	predicted gene 45772	34732	0.19
chr19_34251985_34252204	0.11	Acta2	actin, alpha 2, smooth muscle, aorta	2136	0.26
chr13_12033129_12034063	0.11	Gm47493	predicted gene, 47493	18459	0.21
chr4_145585026_145585604	0.11	Gm13212	predicted gene 13212	112	0.93
chr18_12741375_12742056	0.11	Cabyr	calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)	360	0.78
chr5_150261018_150262108	0.11	Fry	FRY microtubule binding protein	1796	0.34
chrX_106921477_106921682	0.11	Lpar4	lysophosphatidic acid receptor 4	954	0.64
chr17_66276732_66277218	0.11	Gm49932	predicted gene, 49932	40606	0.1
chr12_60595918_60596185	0.11	Gm6068	predicted gene 6068	47813	0.16
chr16_49408257_49408911	0.11	Gm4802	predicted gene 4802	4046	0.24
chr14_56402597_56403081	0.11	Rnf17	ring finger protein 17	139	0.94
chr5_105878641_105878792	0.11	Zfp326	zinc finger protein 326	54	0.93
chr16_72807953_72808738	0.11	Robo1	roundabout guidance receptor 1	145141	0.05
chr16_25945207_25945588	0.11	Gm4524	predicted gene 4524	11078	0.24
chr4_84637359_84638298	0.11	Bnc2	basonuclin 2	37168	0.19
chr10_67056195_67056966	0.11	Reep3	receptor accessory protein 3	19258	0.17
chr14_66325170_66325451	0.11	Gm41183	predicted gene, 41183	15919	0.14
chr11_108336593_108336967	0.11	Apoh	apolipoprotein H	6574	0.19
chr12_9570099_9571217	0.11	1700022H16Rik	RIKEN cDNA 1700022H16 gene	73	0.9
chr2_19014190_19014343	0.11	4930426L09Rik	RIKEN cDNA 4930426L09 gene	15923	0.2
chrX_153037586_153038140	0.11	9530051G07Rik	RIKEN cDNA 9530051G07 gene	234	0.55
chr9_57158351_57158614	0.11	Commd4	COMM domain containing 4	151	0.93
chr13_67332918_67333177	0.11	Zfp595	zinc finger protein 595	477	0.61

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)
0.2	0.5	GO:0051684	maintenance of Golgi location(GO:0051684)
0.2	0.5	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.1	0.2	GO:0090214	spongiotrophoblast layer developmental growth(GO:0090214)
0.1	0.2	GO:0003195	tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195)
0.0	0.1	GO:2000320	negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0097212	lysosomal membrane organization(GO:0097212)
0.0	0.1	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.1	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
0.0	0.1	GO:0060931	sinoatrial node cell development(GO:0060931)
0.0	0.1	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	0.2	GO:0071361	cellular response to ethanol(GO:0071361)
0.0	0.1	GO:1900106	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0	0.0	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0035907	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.2	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0	0.0	GO:0061626	pharyngeal arch artery morphogenesis(GO:0061626)
0.0	0.1	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.1	GO:0070460	thyroid-stimulating hormone secretion(GO:0070460)
0.0	0.2	GO:0086069	bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.1	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.0	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0	0.0	GO:0045914	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.0	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.0	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.0	0.1	GO:0048664	neuron fate determination(GO:0048664)
0.0	0.1	GO:0006054	N-acetylneuraminate metabolic process(GO:0006054)
0.0	0.0	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.0	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.0	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis(GO:0003253)
0.0	0.0	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.0	GO:0019478	D-amino acid catabolic process(GO:0019478)
0.0	0.0	GO:0036216	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.0	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.0	GO:0002159	desmosome assembly(GO:0002159)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	0.1	GO:0016514	SWI/SNF complex(GO:0016514)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.1	GO:0019770	IgG receptor activity(GO:0019770)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.4	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.1	GO:0048030	disaccharide binding(GO:0048030)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.0	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.1	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.1	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.0	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0008410	CoA-transferase activity(GO:0008410)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	1.2	GO:0044325	ion channel binding(GO:0044325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade