Project

ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hoxc10

Z-value: 0.43

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Transcription factors associated with Hoxc10

Gene Symbol	Gene ID	Gene Info
Hoxc10 Ensembl NCBI MGI UniProt	ENSMUSG00000022484.7	Hoxc10

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hoxc10	chr15_102964234_102964441	2459	0.118754	-0.19	1.5e-01	Click!
Hoxc10	chr15_102961468_102962108	5008	0.085565	-0.18	1.7e-01	Click!
Hoxc10	chr15_102964487_102964867	2119	0.132689	-0.17	1.8e-01	Click!
Hoxc10	chr15_102962399_102963013	4090	0.091179	-0.15	2.7e-01	Click!
Hoxc10	chr15_102965066_102967702	412	0.596726	-0.14	2.7e-01	Click!

Activity of the Hoxc10 motif across conditions

Conditions sorted by the z-value of the Hoxc10 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_41702194_41702736	0.40	Kel	Kell blood group	1874	0.23
chr9_91363064_91363717	0.38	Zic1	zinc finger protein of the cerebellum 1	336	0.72
chr8_12399326_12400483	0.37	Gm25239	predicted gene, 25239	3501	0.16
chr5_116589538_116590511	0.36	Srrm4	serine/arginine repetitive matrix 4	1793	0.34
chr2_71536976_71537311	0.36	Dlx1as	distal-less homeobox 1, antisense	667	0.61
chr12_52699339_52699808	0.29	Akap6	A kinase (PRKA) anchor protein 6	190	0.95
chr12_118850924_118851621	0.29	Sp8	trans-acting transcription factor 8	3686	0.27
chr10_92160735_92161461	0.28	Rmst	rhabdomyosarcoma 2 associated transcript (non-coding RNA)	1663	0.4
chr5_98180058_98181966	0.27	Prdm8	PR domain containing 8	34	0.97
chr3_96248416_96249149	0.27	H3c14	H3 clustered histone 14	2097	0.07
chr13_83727321_83728283	0.26	C130071C03Rik	RIKEN cDNA C130071C03 gene	304	0.83
chr6_83315880_83316808	0.26	Gm43890	predicted gene, 43890	599	0.53
chr11_109614897_109615494	0.25	Gm11685	predicted gene 11685	1125	0.43
chr9_91350199_91351559	0.25	A730094K22Rik	RIKEN cDNA A730094K22 gene	74	0.95
chr13_78178635_78180138	0.25	Gm38604	predicted gene, 38604	3773	0.16
chr1_131135705_131136011	0.25	Dyrk3	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	2387	0.21
chr2_38342005_38342312	0.24	Lhx2	LIM homeobox protein 2	1066	0.44
chr2_170192748_170194111	0.24	Zfp217	zinc finger protein 217	45326	0.17
chr4_74300833_74301004	0.24	Kdm4c	lysine (K)-specific demethylase 4C	38108	0.16
chr8_80496570_80496939	0.24	Gypa	glycophorin A	2973	0.3
chr4_96346915_96347066	0.23	Cyp2j11	cytochrome P450, family 2, subfamily j, polypeptide 11	1672	0.4
chr5_8063599_8063897	0.23	Sri	sorcin	2482	0.22
chr6_39418262_39418473	0.23	Mkrn1	makorin, ring finger protein, 1	1390	0.27
chr14_12189998_12191323	0.23	Ptprg	protein tyrosine phosphatase, receptor type, G	717	0.71
chr3_88206822_88208169	0.23	Gm3764	predicted gene 3764	183	0.86
chr2_22625054_22625976	0.22	Gad2	glutamic acid decarboxylase 2	2211	0.22
chr9_91360032_91360505	0.22	Zic4	zinc finger protein of the cerebellum 4	2145	0.17
chr16_35810345_35810496	0.22	Gm26838	predicted gene, 26838	1474	0.31
chr3_17790150_17790808	0.22	Mir124-2hg	Mir124-2 host gene (non-protein coding)	522	0.77
chr14_55061871_55064122	0.22	Gm20687	predicted gene 20687	7503	0.08
chr3_17793389_17793789	0.22	Mir124-2hg	Mir124-2 host gene (non-protein coding)	331	0.86
chr1_26388093_26388357	0.22	Gm19123	predicted gene, 19123	78011	0.12
chr16_18429039_18430122	0.22	Txnrd2	thioredoxin reductase 2	655	0.54
chr3_141989393_141989691	0.22	Bmpr1b	bone morphogenetic protein receptor, type 1B	7278	0.31
chr10_21695137_21695288	0.22	Gm5420	predicted gene 5420	4367	0.25
chr17_66869630_66870110	0.21	Gm49940	predicted gene, 49940	7630	0.18
chr13_99493273_99493585	0.21	5330431K02Rik	RIKEN cDNA 5330431K02 gene	11010	0.16
chr2_31638722_31641540	0.21	Prdm12	PR domain containing 12	94	0.84
chr1_57083098_57083538	0.21	9130024F11Rik	RIKEN cDNA 9130024F11 gene	42925	0.14
chr1_40771505_40772300	0.21	Gm37915	predicted gene, 37915	517	0.75
chr8_41052368_41053980	0.21	Gm16193	predicted gene 16193	64	0.96
chr17_46485045_46485196	0.21	Ttbk1	tau tubulin kinase 1	825	0.43
chr11_20330074_20330777	0.21	Slc1a4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	2259	0.28
chr1_25228097_25229399	0.21	Adgrb3	adhesion G protein-coupled receptor B3	78	0.96
chr3_104632268_104633005	0.21	Gm43582	predicted gene 43582	2021	0.18
chr6_34869198_34869349	0.21	Tmem140	transmembrane protein 140	2221	0.2
chrX_166346283_166346827	0.21	Gpm6b	glycoprotein m6b	1713	0.43
chr4_23636118_23636607	0.21	Gm25978	predicted gene, 25978	9617	0.24
chr3_121460231_121460981	0.20	Slc44a3	solute carrier family 44, member 3	305	0.86
chr18_34519817_34520312	0.20	n-R5s24	nuclear encoded rRNA 5S 24	10327	0.14
chr4_46453910_46454934	0.20	Anp32b	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B	3520	0.17
chr4_48050018_48050169	0.20	Nr4a3	nuclear receptor subfamily 4, group A, member 3	979	0.62
chr13_83749435_83750073	0.20	C130071C03Rik	RIKEN cDNA C130071C03 gene	10891	0.12
chr1_95665138_95666758	0.20	St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	1587	0.41
chr18_70573145_70573296	0.20	Mbd2	methyl-CpG binding domain protein 2	4886	0.22
chr18_25751839_25752425	0.19	Celf4	CUGBP, Elav-like family member 4	560	0.81
chr7_70347472_70349327	0.19	Gm44948	predicted gene 44948	703	0.54
chr1_133755015_133755406	0.19	Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	1463	0.34
chr4_125727107_125727874	0.19	2610028E06Rik	RIKEN cDNA 2610028E06 gene	171492	0.03
chr4_110285468_110287125	0.19	Elavl4	ELAV like RNA binding protein 4	320	0.94
chr9_19302176_19302327	0.19	Olfr844	olfactory receptor 844	14096	0.13
chr13_23451039_23451496	0.19	Gm46404	predicted gene, 46404	5332	0.09
chr16_35809219_35809489	0.19	Gm26838	predicted gene, 26838	408	0.78
chr1_58960528_58960716	0.19	Trak2	trafficking protein, kinesin binding 2	12807	0.14
chr1_42688699_42689514	0.19	Pantr1	POU domain, class 3, transcription factor 3 adjacent noncoding transcript 1	3987	0.16
chr8_84768788_84768967	0.19	Nfix	nuclear factor I/X	4519	0.13
chr10_14703599_14704234	0.19	Vta1	vesicle (multivesicular body) trafficking 1	1543	0.26
chr9_48338929_48340200	0.19	Nxpe2	neurexophilin and PC-esterase domain family, member 2	1270	0.48
chr1_162866141_162866550	0.18	Fmo1	flavin containing monooxygenase 1	265	0.91
chr8_47346057_47346419	0.18	Stox2	storkhead box 2	6110	0.26
chr16_81285172_81285323	0.18	Gm49555	predicted gene, 49555	4915	0.27
chr2_105678552_105679922	0.18	Pax6	paired box 6	630	0.68
chr10_103026340_103027824	0.18	Alx1	ALX homeobox 1	1545	0.39
chr8_123858032_123858183	0.18	Ccsap	centriole, cilia and spindle associated protein	1423	0.23
chr1_177448882_177449429	0.18	Zbtb18	zinc finger and BTB domain containing 18	3334	0.19
chr14_69278760_69279066	0.18	Gm20236	predicted gene, 20236	3227	0.12
chrX_110811626_110812334	0.18	Gm44593	predicted gene 44593	344	0.89
chr8_12400578_12402091	0.18	Gm25239	predicted gene, 25239	4931	0.15
chr10_67002257_67005140	0.18	Gm31763	predicted gene, 31763	1322	0.45
chr10_94020545_94020760	0.18	Vezt	vezatin, adherens junctions transmembrane protein	71	0.96
chr2_28620746_28622145	0.18	Gfi1b	growth factor independent 1B	500	0.68
chr19_31028064_31028215	0.18	Cstf2t	cleavage stimulation factor, 3' pre-RNA subunit 2, tau	54698	0.16
chr14_122480308_122481080	0.18	Zic2	zinc finger protein of the cerebellum 2	2594	0.16
chr6_113890285_113891668	0.18	Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	394	0.85
chr7_121070927_121071078	0.18	Igsf6	immunoglobulin superfamily, member 6	3570	0.11
chr4_100855622_100855877	0.18	Cachd1	cache domain containing 1	79074	0.1
chr11_32290084_32290341	0.17	Hbq1b	hemoglobin, theta 1B	3211	0.13
chr9_77994297_77994513	0.17	Gm34829	predicted gene, 34829	1806	0.24
chr14_32146045_32146369	0.17	Msmb	beta-microseminoprotein	1380	0.29
chr16_77422348_77423278	0.17	9430053O09Rik	RIKEN cDNA 9430053O09 gene	993	0.4
chr17_3482528_3483679	0.17	Tiam2	T cell lymphoma invasion and metastasis 2	387	0.86
chr5_137024960_137025964	0.17	Vgf	VGF nerve growth factor inducible	930	0.37
chr1_42701498_42701775	0.17	Pou3f3	POU domain, class 3, transcription factor 3	5868	0.14
chr12_53061586_53062872	0.17	n-R5s58	nuclear encoded rRNA 5S 58	15403	0.29
chr2_61806407_61806964	0.17	Tbr1	T-box brain gene 1	412	0.83
chr13_9095816_9096692	0.17	Larp4b	La ribonucleoprotein domain family, member 4B	2272	0.25
chr9_91363965_91365514	0.17	Zic1	zinc finger protein of the cerebellum 1	1029	0.35
chr3_129836696_129837785	0.17	Cfi	complement component factor i	503	0.7
chr19_59347278_59347441	0.17	Pdzd8	PDZ domain containing 8	1579	0.32
chr9_74865733_74868961	0.17	Onecut1	one cut domain, family member 1	863	0.54
chr19_56543836_56544364	0.17	Dclre1a	DNA cross-link repair 1A	2555	0.26
chr7_27735092_27735839	0.17	Zfp60	zinc finger protein 60	902	0.47
chr3_34656299_34657721	0.17	Sox2ot	SOX2 overlapping transcript (non-protein coding)	974	0.4
chr11_111996362_111996587	0.17	Gm11679	predicted gene 11679	47104	0.19
chr4_53633406_53634189	0.17	Fsd1l	fibronectin type III and SPRY domain containing 1-like	2081	0.3
chr16_43509882_43510133	0.17	Zbtb20	zinc finger and BTB domain containing 20	301	0.93
chr10_26230524_26230675	0.17	Samd3	sterile alpha motif domain containing 3	3	0.98
chr9_66276261_66276412	0.17	Dapk2	death-associated protein kinase 2	7962	0.23
chr11_96347886_96350398	0.17	Hoxb3os	homeobox B3 and homeobox B2, opposite strand	1219	0.21
chr11_98708998_98709149	0.17	Med24	mediator complex subunit 24	1070	0.29
chr2_48538709_48539576	0.16	Gm13481	predicted gene 13481	81897	0.1
chr15_77953936_77954120	0.16	Foxred2	FAD-dependent oxidoreductase domain containing 2	2647	0.2
chr1_42242281_42242432	0.16	Gm29664	predicted gene 29664	3661	0.22
chr8_85378394_85378546	0.16	Mylk3	myosin light chain kinase 3	2508	0.21
chr17_25090137_25090691	0.16	Ift140	intraflagellar transport 140	257	0.85
chr1_142984549_142984700	0.16	Gm5835	predicted gene 5835	109992	0.07
chr19_28677931_28680368	0.16	Glis3	GLIS family zinc finger 3	459	0.68
chr10_57787071_57787893	0.16	Fabp7	fatty acid binding protein 7, brain	2559	0.25
chr14_19974553_19975713	0.16	Gng2	guanine nucleotide binding protein (G protein), gamma 2	1560	0.43
chr1_165766563_165766714	0.16	Creg1	cellular repressor of E1A-stimulated genes 1	2838	0.13
chr18_31446492_31447667	0.16	Syt4	synaptotagmin IV	327	0.87
chr1_42262366_42263014	0.16	Gm28175	predicted gene 28175	833	0.63
chr16_30266391_30266905	0.16	Cpn2	carboxypeptidase N, polypeptide 2	851	0.52
chr6_6857856_6858925	0.16	Gm44094	predicted gene, 44094	2139	0.2
chr9_83253415_83254213	0.16	Gm27216	predicted gene 27216	208	0.95
chr2_70567574_70569064	0.16	Gad1	glutamate decarboxylase 1	1942	0.26
chr14_34623313_34624132	0.16	Opn4	opsin 4 (melanopsin)	23580	0.11
chr3_34562856_34563429	0.16	Sox2ot	SOX2 overlapping transcript (non-protein coding)	2750	0.22
chr2_23037510_23037739	0.16	Abi1	abl-interactor 1	2480	0.26
chr5_88587396_88587564	0.16	Rufy3	RUN and FYVE domain containing 3	3686	0.2
chr2_52557337_52558561	0.16	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	611	0.74
chr1_42230426_42230769	0.16	Gm9915	predicted gene 9915	870	0.59
chr7_53564328_53564479	0.16	Mir6238	microRNA 6238	327486	0.01
chr9_52145956_52147029	0.16	Zc3h12c	zinc finger CCCH type containing 12C	21619	0.17
chr14_115043258_115044172	0.16	Mir17	microRNA 17	44	0.47
chr13_83715222_83716973	0.16	C130071C03Rik	RIKEN cDNA C130071C03 gene	5284	0.15
chr3_56179928_56180616	0.16	Nbea	neurobeachin	3429	0.25
chr12_49394720_49395481	0.16	3110039M20Rik	RIKEN cDNA 3110039M20 gene	4441	0.15
chr9_91366433_91367646	0.15	Zic1	zinc finger protein of the cerebellum 1	1229	0.26
chr2_105671719_105672950	0.15	Pax6	paired box 6	474	0.75
chr10_119878178_119878329	0.15	Grip1os1	glutamate receptor interacting protein 1, opposite strand 1	25863	0.19
chr15_66809584_66809797	0.15	Sla	src-like adaptor	2903	0.26
chr1_178299267_178300366	0.15	Gm37486	predicted gene, 37486	420	0.74
chr12_49390931_49392462	0.15	3110039M20Rik	RIKEN cDNA 3110039M20 gene	1037	0.42
chr12_56532060_56532690	0.15	Nkx2-1	NK2 homeobox 1	2731	0.16
chr6_38121806_38121957	0.15	Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	2608	0.21
chr13_83742301_83742867	0.15	C130071C03Rik	RIKEN cDNA C130071C03 gene	3721	0.15
chr4_46401482_46401633	0.15	Hemgn	hemogen	2679	0.19
chr2_16360798_16360949	0.15	Plxdc2	plexin domain containing 2	3756	0.39
chr13_97250234_97250508	0.15	Enc1	ectodermal-neural cortex 1	9266	0.17
chr18_39904089_39904240	0.15	Gm41708	predicted gene, 41708	25210	0.24
chr4_100616357_100616508	0.15	Gm12700	predicted gene 12700	35154	0.17
chr7_79505833_79506958	0.15	Mir9-3	microRNA 9-3	1131	0.28
chr2_86873075_86873226	0.15	Gm13723	predicted gene 13723	1652	0.22
chr11_78074087_78074838	0.15	Mir451b	microRNA 451b	1221	0.18
chr1_168425831_168426144	0.15	Pbx1	pre B cell leukemia homeobox 1	5517	0.27
chr14_60636814_60637375	0.15	Spata13	spermatogenesis associated 13	2339	0.35
chr14_29807795_29808268	0.15	Gm35281	predicted gene, 35281	19266	0.19
chr13_83717521_83718816	0.15	C130071C03Rik	RIKEN cDNA C130071C03 gene	3213	0.17
chr8_80495549_80496014	0.15	Gypa	glycophorin A	2000	0.38
chr6_17750183_17750783	0.15	St7	suppression of tumorigenicity 7	1091	0.38
chr9_14369210_14369409	0.15	Endod1	endonuclease domain containing 1	11674	0.12
chr16_18430494_18430682	0.15	Txnrd2	thioredoxin reductase 2	1663	0.22
chrX_166172119_166172805	0.15	Gemin8	gem nuclear organelle associated protein 8	1967	0.37
chr9_113970028_113970753	0.15	Gm47950	predicted gene, 47950	608	0.61
chr18_43686487_43688415	0.15	Jakmip2	janus kinase and microtubule interacting protein 2	174	0.96
chr9_75232729_75232880	0.14	Myo5c	myosin VC	728	0.65
chr6_15186533_15187348	0.14	Foxp2	forkhead box P2	1377	0.61
chr10_42581935_42584872	0.14	Nr2e1	nuclear receptor subfamily 2, group E, member 1	229	0.69
chr8_120507179_120507330	0.14	Gm26971	predicted gene, 26971	13361	0.12
chr17_80801064_80802812	0.14	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	73453	0.09
chr4_23601397_23602347	0.14	Gm25978	predicted gene, 25978	24873	0.22
chr6_57822563_57823744	0.14	Vopp1	vesicular, overexpressed in cancer, prosurvival protein 1	1487	0.3
chr2_138118544_138118695	0.14	Btbd3	BTB (POZ) domain containing 3	137946	0.05
chr16_91397742_91397893	0.14	Gm21970	predicted gene 21970	6096	0.12
chr8_41054160_41054452	0.14	Mtus1	mitochondrial tumor suppressor 1	477	0.69
chr4_147814549_147814848	0.14	Gm20707	predicted gene 20707	4858	0.11
chr11_118496296_118496447	0.14	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	10982	0.14
chr7_24935298_24935521	0.14	Erfl	ETS repressor factor like	9085	0.09
chr12_98562134_98562933	0.14	Kcnk10	potassium channel, subfamily K, member 10	12179	0.14
chr4_22485088_22485284	0.14	Pou3f2	POU domain, class 3, transcription factor 2	3180	0.21
chr4_134470669_134471383	0.14	Stmn1	stathmin 1	1284	0.28
chr10_93883117_93883275	0.14	Metap2	methionine aminopeptidase 2	4290	0.15
chr6_56017510_56018185	0.14	Ppp1r17	protein phosphatase 1, regulatory subunit 17	350	0.93
chr4_44247087_44247879	0.14	Rnf38	ring finger protein 38	13694	0.17
chr17_25017468_25017619	0.14	Ift140	intraflagellar transport 140	1144	0.33
chr3_118432535_118432944	0.14	Gm26871	predicted gene, 26871	1058	0.3
chr6_129352639_129352989	0.14	Clec12a	C-type lectin domain family 12, member a	2850	0.17
chr3_149190517_149191107	0.14	Gm42647	predicted gene 42647	19459	0.21
chr17_93555961_93556112	0.14	Gm50002	predicted gene, 50002	124629	0.05
chr2_93278081_93278912	0.14	Tspan18	tetraspanin 18	34019	0.17
chr8_39514538_39514692	0.14	Gm5609	predicted gene 5609	58705	0.15
chr11_32199697_32199897	0.14	Il9r	interleukin 9 receptor	425	0.73
chr17_57769126_57770140	0.14	Cntnap5c	contactin associated protein-like 5C	63	0.97
chr2_126490465_126490739	0.14	Atp8b4	ATPase, class I, type 8B, member 4	951	0.64
chr16_64855062_64855213	0.14	Cggbp1	CGG triplet repeat binding protein 1	2435	0.26
chr17_50967883_50968034	0.14	Tbc1d5	TBC1 domain family, member 5	16668	0.25
chr15_103016875_103017501	0.14	Hoxc4	homeobox C4	1746	0.16
chr4_22481988_22482455	0.13	Pou3f2	POU domain, class 3, transcription factor 2	6145	0.18
chr2_61808611_61809537	0.13	Tbr1	T-box brain gene 1	2801	0.25

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc10

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.1	0.3	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1	0.4	GO:2000481	positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.1	0.2	GO:0099558	maintenance of synapse structure(GO:0099558)
0.1	0.3	GO:0021764	amygdala development(GO:0021764)
0.1	0.2	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.1	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
0.0	0.2	GO:1900109	regulation of histone H3-K9 dimethylation(GO:1900109)
0.0	0.3	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.0	0.2	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.0	0.1	GO:0034184	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.2	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.1	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0038095	Fc-epsilon receptor signaling pathway(GO:0038095)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:0072235	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0	0.2	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.2	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.0	0.2	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.1	GO:0021778	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.2	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.1	GO:0034182	regulation of maintenance of sister chromatid cohesion(GO:0034091) regulation of maintenance of mitotic sister chromatid cohesion(GO:0034182)
0.0	0.1	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.2	GO:0021877	forebrain neuron fate commitment(GO:0021877)
0.0	0.1	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
0.0	0.1	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.0	0.2	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.0	0.2	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.1	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.1	GO:0032252	secretory granule localization(GO:0032252)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:2000850	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.0	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0016198	axon choice point recognition(GO:0016198)
0.0	0.1	GO:1902101	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.0	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.0	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.0	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.1	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.0	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.0	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0	0.0	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.4	GO:0048821	erythrocyte development(GO:0048821)
0.0	0.0	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.1	GO:0021521	ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0	0.1	GO:0097475	motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.0	0.1	GO:0090274	positive regulation of somatostatin secretion(GO:0090274)
0.0	0.0	GO:0009946	proximal/distal axis specification(GO:0009946)
0.0	0.1	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.0	GO:1904936	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0	0.0	GO:0045914	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.0	GO:0061743	motor learning(GO:0061743)
0.0	0.1	GO:0036508	protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0	0.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.0	GO:0002434	immune complex clearance(GO:0002434)
0.0	0.1	GO:0010587	miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0006868	glutamine transport(GO:0006868)
0.0	0.1	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.2	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.1	GO:1902837	amino acid import into cell(GO:1902837)
0.0	0.0	GO:0060166	olfactory pit development(GO:0060166)
0.0	0.1	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	0.0	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0	0.0	GO:0046061	dATP catabolic process(GO:0046061)
0.0	0.1	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.0	0.0	GO:0046125	pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0	0.0	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.0	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.1	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.0	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.6	GO:0021510	spinal cord development(GO:0021510)
0.0	0.1	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.1	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.0	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.0	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.0	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.0	GO:0030070	insulin processing(GO:0030070)
0.0	0.0	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.0	0.1	GO:0071918	urea transmembrane transport(GO:0071918)
0.0	0.1	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.2	GO:0000305	response to oxygen radical(GO:0000305)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.0	GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0001504	neurotransmitter uptake(GO:0001504)
0.0	0.1	GO:0035881	amacrine cell differentiation(GO:0035881)
0.0	0.1	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.0	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.1	GO:0046984	regulation of hemoglobin biosynthetic process(GO:0046984)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	0.2	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.3	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0001674	female germ cell nucleus(GO:0001674)
0.0	0.2	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.2	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.0	GO:1990423	RZZ complex(GO:1990423)
0.0	0.0	GO:0005712	chiasma(GO:0005712)
0.0	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.2	GO:0032433	filopodium tip(GO:0032433)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.0	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.0	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.2	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.1	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	0.1	GO:0089701	U2AF(GO:0089701)
0.0	0.1	GO:0071565	nBAF complex(GO:0071565)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.0	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	0.4	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.3	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.1	0.2	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.3	GO:0043495	protein anchor(GO:0043495)
0.0	0.3	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.1	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.0	0.1	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0052723	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0031720	haptoglobin binding(GO:0031720)
0.0	0.1	GO:0004487	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.0	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.0	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.0	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0001884	pyrimidine nucleoside binding(GO:0001884)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.0	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.3	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.0	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.0	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.0	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.0	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX	Genes involved in Formation of the HIV-1 Early Elongation Complex
0.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.3	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.1	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs