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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Hoxd12

Z-value: 0.50

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Transcription factors associated with Hoxd12

Gene Symbol	Gene ID	Gene Info
Hoxd12 Ensembl NCBI MGI UniProt	ENSMUSG00000001823.4	homeobox D12

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_74673537_74673688	Hoxd12	1401	0.158620	0.26	4.5e-02	Click!
chr2_74672425_74673160	Hoxd12	2221	0.099583	0.24	6.3e-02	Click!
chr2_74673325_74673476	Hoxd12	1613	0.135621	0.24	6.6e-02	Click!
chr2_74676368_74676604	Hoxd12	1473	0.145217	0.21	1.1e-01	Click!
chr2_74675065_74676326	Hoxd12	682	0.366054	0.20	1.3e-01	Click!

Activity of the Hoxd12 motif across conditions

Conditions sorted by the z-value of the Hoxd12 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_21485587_21486692	0.82	Agtr2	angiotensin II receptor, type 2	1417	0.41
chr6_16797640_16797838	0.63	Gm36669	predicted gene, 36669	20215	0.22
chr10_20723138_20723899	0.60	Pde7b	phosphodiesterase 7B	1178	0.55
chr18_49117603_49118121	0.55	Gm18993	predicted gene, 18993	54438	0.18
chr2_74063525_74063783	0.55	A630050E04Rik	RIKEN cDNA A630050E04 gene	38688	0.15
chr5_3432895_3433605	0.51	Cdk6	cyclin-dependent kinase 6	37699	0.12
chr3_48846231_48846444	0.50	Gm37190	predicted gene, 37190	85388	0.1
chr16_74408614_74409150	0.50	Robo2	roundabout guidance receptor 2	2030	0.43
chr12_36315313_36316308	0.48	Sostdc1	sclerostin domain containing 1	1671	0.31
chr5_48003784_48004411	0.48	4930518C09Rik	RIKEN cDNA 4930518C09 gene	1610	0.28
chr8_85698168_85698436	0.46	Neto2	neuropilin (NRP) and tolloid (TLL)-like 2	2452	0.21
chr18_40258245_40258964	0.45	Gm31087	predicted gene, 31087	109	0.63
chr10_125967599_125967789	0.44	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	1441	0.55
chrX_104198423_104198882	0.44	Nexmif	neurite extension and migration factor	2465	0.34
chr4_84403786_84404211	0.43	Gm12421	predicted gene 12421	25126	0.25
chr8_65036064_65036521	0.40	Gm45886	predicted gene 45886	804	0.33
chr18_60377377_60377703	0.40	Iigp1	interferon inducible GTPase 1	1493	0.33
chr3_149705320_149706167	0.40	Gm31121	predicted gene, 31121	45347	0.2
chr5_32059174_32059703	0.40	Babam2	BRISC and BRCA1 A complex member 2	13460	0.19
chr16_77593272_77593433	0.40	Mir99ahg	Mir99a and Mirlet7c-1 host gene (non-protein coding)	476	0.66
chr1_168425173_168425741	0.40	Pbx1	pre B cell leukemia homeobox 1	6047	0.27
chr2_169099862_169100013	0.39	Gm14258	predicted gene 14258	6516	0.23
chr1_143640264_143641520	0.39	B3galt2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2	228	0.59
chr6_49009229_49009402	0.39	4930563H07Rik	RIKEN cDNA 4930563H07 gene	9699	0.08
chr1_21500023_21500174	0.38	Gm7658	predicted gene 7658	12958	0.19
chr14_108415348_108415499	0.38	Gm24818	predicted gene, 24818	35859	0.24
chr17_51461105_51461697	0.37	Gm46574	predicted gene, 46574	23320	0.19
chr10_59950135_59950286	0.36	Ddit4	DNA-damage-inducible transcript 4	1624	0.36
chr16_92692721_92692872	0.36	Runx1	runt related transcription factor 1	2699	0.35
chr8_91948462_91949309	0.36	Gm28515	predicted gene 28515	35819	0.12
chr8_47351619_47352381	0.36	Stox2	storkhead box 2	348	0.91
chr4_134372795_134372981	0.35	Extl1	exostosin-like glycosyltransferase 1	330	0.82
chr6_6880959_6882181	0.35	Dlx5	distal-less homeobox 5	498	0.71
chr7_118902757_118903362	0.34	Iqck	IQ motif containing K	34064	0.13
chr14_80901423_80902185	0.34	Gm49044	predicted gene, 49044	28933	0.21
chr4_81566839_81567150	0.33	Gm11765	predicted gene 11765	105262	0.07
chr3_149443059_149443897	0.33	Gm30382	predicted gene, 30382	1798	0.48
chr5_44796139_44796769	0.33	Ldb2	LIM domain binding 2	3148	0.24
chr19_20009817_20010437	0.32	Gm22684	predicted gene, 22684	23508	0.22
chr8_58909555_58909706	0.32	Galntl6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	1946	0.34
chr3_149358058_149358806	0.32	Gm26468	predicted gene, 26468	17424	0.19
chr15_21110687_21111815	0.32	Cdh12	cadherin 12	201	0.94
chr3_86759901_86760193	0.32	Gm37876	predicted gene, 37876	18606	0.19
chr12_34385779_34385930	0.32	Hdac9	histone deacetylase 9	51453	0.17
chr5_119690061_119690212	0.32	Tbx3os2	T-box 3, opposite strand 2	1082	0.45
chr16_74070800_74070951	0.32	Gm49660	predicted gene, 49660	5022	0.22
chr19_14670192_14670662	0.32	Gm37997	predicted gene, 37997	11760	0.25
chr1_186546580_186547168	0.32	A730004F24Rik	RIKEN cDNA A730004F24 gene	11598	0.25
chr6_129450832_129451818	0.32	Clec1a	C-type lectin domain family 1, member a	510	0.65
chrX_88113433_88114223	0.31	Il1rapl1	interleukin 1 receptor accessory protein-like 1	1817	0.46
chr11_86472817_86473930	0.31	Rnft1	ring finger protein, transmembrane 1	11284	0.16
chr5_18358524_18358675	0.31	Gnai1	guanine nucleotide binding protein (G protein), alpha inhibiting 1	1756	0.43
chr15_43662128_43662279	0.31	Gm2140	predicted gene 2140	146258	0.04
chr2_46442289_46442440	0.31	Gm13470	predicted gene 13470	346	0.92
chr2_137356841_137357676	0.31	Gm14055	predicted gene 14055	68755	0.13
chr18_37481682_37481833	0.31	Pcdhb17	protocadherin beta 17	3038	0.09
chr11_24980356_24980734	0.31	Gm12665	predicted gene 12665	54487	0.17
chr15_37231016_37231198	0.30	Grhl2	grainyhead like transcription factor 2	1929	0.24
chr15_39391612_39392273	0.30	Rims2	regulating synaptic membrane exocytosis 2	142	0.97
chr15_102594215_102594505	0.29	Atf7	activating transcription factor 7	30562	0.08
chr18_83557517_83557756	0.29	Gm50416	predicted gene, 50416	32332	0.14
chr1_69591259_69591484	0.29	Gm29112	predicted gene 29112	7151	0.24
chr1_69790500_69791180	0.29	Gm37930	predicted gene, 37930	19972	0.21
chr17_85693787_85694529	0.28	CJ186046Rik	Riken cDNA CJ186046 gene	529	0.77
chr1_119052514_119053221	0.28	Gli2	GLI-Kruppel family member GLI2	472	0.83
chr3_42074735_42075052	0.28	Gm37846	predicted gene, 37846	88972	0.08
chr16_65560252_65560595	0.28	Chmp2b	charged multivesicular body protein 2B	2097	0.32
chr18_69349288_69349439	0.28	Tcf4	transcription factor 4	419	0.89
chr17_64329718_64329909	0.28	Pja2	praja ring finger ubiquitin ligase 2	2052	0.38
chr15_81936444_81938042	0.28	Csdc2	cold shock domain containing C2, RNA binding	261	0.82
chr2_44558382_44559022	0.28	Gtdc1	glycosyltransferase-like domain containing 1	12645	0.3
chr16_89958503_89958654	0.28	Tiam1	T cell lymphoma invasion and metastasis 1	2159	0.43
chr12_47373270_47373421	0.28	Gm48578	predicted gene, 48578	158912	0.04
chr1_14357767_14358207	0.27	Eya1	EYA transcriptional coactivator and phosphatase 1	47752	0.18
chr14_36918744_36919600	0.27	Ccser2	coiled-coil serine rich 2	161	0.97
chr17_43571796_43572049	0.27	Pla2g7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	3207	0.21
chr18_32941213_32941434	0.27	2310026I22Rik	RIKEN cDNA 2310026I22 gene	2094	0.27
chr9_103212682_103213306	0.27	Trf	transferrin	988	0.51
chr2_59438620_59439113	0.27	Gm13549	predicted gene 13549	39085	0.13
chr17_3397051_3398448	0.27	Tiam2	T cell lymphoma invasion and metastasis 2	519	0.8
chr13_49610100_49610769	0.27	Ogn	osteoglycin	2388	0.21
chr9_66004589_66004841	0.27	Csnk1g1	casein kinase 1, gamma 1	3025	0.23
chr14_7774273_7774663	0.26	Gm10044	predicted gene 10044	329	0.85
chr12_101815999_101816150	0.26	Fbln5	fibulin 5	2394	0.3
chr3_63851016_63851674	0.26	Plch1	phospholipase C, eta 1	14	0.97
chr2_135661117_135661413	0.26	Plcb4	phospholipase C, beta 4	1554	0.35
chr7_115920406_115920948	0.26	Sox6	SRY (sex determining region Y)-box 6	60825	0.12
chr18_57785762_57786717	0.26	Gm19519	predicted gene, 19519	6094	0.27
chr7_16948879_16949030	0.26	Pnmal2	PNMA-like 2	4272	0.1
chr5_49284738_49286021	0.26	Kcnip4	Kv channel interacting protein 4	280	0.92
chr5_116312100_116312726	0.26	B230112J18Rik	RIKEN cDNA B230112J18 gene	53	0.96
chr5_76823713_76823864	0.26	C530008M17Rik	RIKEN cDNA C530008M17 gene	13800	0.19
chr7_45627553_45628284	0.26	Rasip1	Ras interacting protein 1	430	0.56
chr15_16730998_16731546	0.25	Cdh9	cadherin 9	2516	0.41
chr10_42861990_42862751	0.25	Scml4	Scm polycomb group protein like 4	1577	0.26
chr8_50913867_50914080	0.25	C130073E24Rik	RIKEN cDNA C130073E24 gene	3024	0.4
chr5_150260534_150260992	0.25	Fry	FRY microtubule binding protein	996	0.55
chr13_91916211_91916382	0.25	Ckmt2	creatine kinase, mitochondrial 2	39411	0.15
chr8_94265837_94266069	0.25	Nup93	nucleoporin 93	894	0.46
chr14_101841178_101841822	0.25	Lmo7	LIM domain only 7	681	0.79
chr2_27890316_27890530	0.25	2810430I11Rik	RIKEN cDNA 2810430I11 gene	3371	0.26
chr7_69845047_69845447	0.25	Gm44690	predicted gene 44690	39113	0.19
chr4_76440840_76441299	0.25	Ptprd	protein tyrosine phosphatase, receptor type, D	8911	0.22
chr13_97216191_97216342	0.25	Gm48881	predicted gene, 48881	13291	0.14
chr3_116923152_116923435	0.25	Gm42892	predicted gene 42892	21037	0.12
chr2_16358886_16359826	0.25	Plxdc2	plexin domain containing 2	2239	0.48
chr1_17601856_17602960	0.25	Pi15	peptidase inhibitor 15	507	0.82
chr12_95699008_95699374	0.24	Flrt2	fibronectin leucine rich transmembrane protein 2	3834	0.21
chr16_93272287_93272901	0.24	1810053B23Rik	RIKEN cDNA 1810053B23 gene	80595	0.09
chr3_149257135_149257363	0.24	Gm10287	predicted gene 10287	31504	0.16
chr16_28751131_28751282	0.24	Fgf12	fibroblast growth factor 12	1862	0.48
chr10_103020026_103020270	0.24	Alx1	ALX homeobox 1	2426	0.3
chr3_141464293_141464444	0.24	Unc5c	unc-5 netrin receptor C	848	0.47
chr6_148441933_148442246	0.24	Tmtc1	transmembrane and tetratricopeptide repeat containing 1	454	0.84
chrX_103819527_103819771	0.24	Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	2334	0.25
chr1_146492868_146493351	0.24	Brinp3	bone morphogenetic protein/retinoic acid inducible neural specific 3	1651	0.31
chr5_112153542_112154115	0.24	1700016B01Rik	RIKEN cDNA 1700016B01 gene	2409	0.28
chr3_56181373_56181654	0.24	Nbea	neurobeachin	2188	0.32
chr1_45312046_45312607	0.23	Gm47302	predicted gene, 47302	653	0.46
chr6_4506970_4507670	0.23	Gm43921	predicted gene, 43921	1233	0.34
chr8_25911399_25912280	0.23	Kcnu1	potassium channel, subfamily U, member 1	147	0.95
chr8_36147717_36147868	0.23	Gm38414	predicted gene, 38414	8218	0.16
chr11_16753788_16754062	0.23	Egfr	epidermal growth factor receptor	1695	0.38
chr13_64040042_64040324	0.23	Hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	22950	0.17
chr3_30546274_30547260	0.23	Mecom	MDS1 and EVI1 complex locus	1241	0.35
chr15_87546913_87547689	0.23	Tafa5	TAFA chemokine like family member 5	3002	0.41
chr6_58905319_58905541	0.23	Nap1l5	nucleosome assembly protein 1-like 5	1243	0.38
chr6_105676979_105678296	0.23	Cntn4	contactin 4	23	0.52
chr14_97931267_97931418	0.23	Gm25831	predicted gene, 25831	36649	0.23
chr10_24235368_24236239	0.23	Moxd1	monooxygenase, DBH-like 1	12258	0.2
chr6_4509880_4510830	0.22	Gm43921	predicted gene, 43921	4268	0.17
chr9_117318478_117318629	0.22	Gm17396	predicted gene, 17396	66017	0.12
chr15_16564836_16564987	0.22	Gm2611	predicted gene 2611	35651	0.19
chr1_190977127_190977297	0.22	Vash2	vasohibin 2	1790	0.22
chr9_113387561_113387731	0.22	Gm36485	predicted gene, 36485	32414	0.15
chr15_36960162_36960613	0.22	Gm34590	predicted gene, 34590	21523	0.14
chr17_75177945_75179637	0.22	Ltbp1	latent transforming growth factor beta binding protein 1	19	0.98
chr7_113950384_113950535	0.22	Gm45615	predicted gene 45615	136439	0.04
chr6_44179699_44179850	0.22	Gm35216	predicted gene, 35216	96419	0.09
chr13_112998291_112999283	0.22	Mcidas	multiciliate differentiation and DNA synthesis associated cell cycle protein	4942	0.11
chr10_23345710_23346907	0.22	Eya4	EYA transcriptional coactivator and phosphatase 4	3579	0.36
chr3_146851868_146852360	0.22	Ttll7	tubulin tyrosine ligase-like family, member 7	253	0.92
chr19_36734732_36735279	0.22	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	1648	0.41
chr19_34101834_34101985	0.22	Lipm	lipase, family member M	969	0.49
chr8_61316532_61316683	0.21	1700001D01Rik	RIKEN cDNA 1700001D01 gene	27735	0.16
chr14_57056590_57056818	0.21	Gja3	gap junction protein, alpha 3	1019	0.5
chr18_82006563_82006720	0.21	Gm50293	predicted gene, 50293	10807	0.17
chr15_93592923_93593281	0.21	Prickle1	prickle planar cell polarity protein 1	2789	0.35
chr2_110949491_110950578	0.21	Ano3	anoctamin 3	338	0.92
chr7_139978745_139979435	0.21	Spef1l	sperm flagellar 1 like	335	0.7
chr9_117870768_117871285	0.21	Rbms3	RNA binding motif, single stranded interacting protein	1558	0.39
chr2_113755577_113755728	0.21	Grem1	gremlin 1, DAN family BMP antagonist	2994	0.27
chr3_131566361_131566512	0.21	Papss1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	1501	0.48
chr1_45520505_45520757	0.21	Gm7063	predicted gene 7063	123	0.96
chr6_141252051_141252954	0.21	Gm28523	predicted gene 28523	2493	0.28
chr2_78210324_78210475	0.21	Gm14461	predicted gene 14461	27148	0.25
chr17_86350533_86350917	0.21	2010106C02Rik	RIKEN cDNA 2010106C02 gene	63547	0.13
chr13_31810334_31810485	0.21	Foxc1	forkhead box C1	3776	0.2
chr14_48207086_48207793	0.21	Peli2	pellino 2	8723	0.15
chr3_151833797_151834654	0.21	Ptgfr	prostaglandin F receptor	70	0.97
chr12_95699798_95699986	0.21	Flrt2	fibronectin leucine rich transmembrane protein 2	4535	0.2
chrX_95166552_95167109	0.21	Arhgef9	CDC42 guanine nucleotide exchange factor (GEF) 9	291	0.93
chr19_56822342_56822651	0.21	Ccdc186	coiled-coil domain containing 186	306	0.88
chr10_125967796_125968797	0.21	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	2043	0.45
chr3_151002106_151002257	0.21	Mir3963	microRNA 3963	21681	0.23
chr14_48654042_48654193	0.21	Gm23469	predicted gene, 23469	1618	0.2
chr9_62857494_62859103	0.21	Calml4	calmodulin-like 4	164	0.92
chr12_117245902_117246283	0.20	Mir153	microRNA 153	4725	0.31
chr17_80772743_80773228	0.20	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	44500	0.15
chr16_21207731_21208515	0.20	Ephb3	Eph receptor B3	2401	0.25
chr15_81189593_81189780	0.20	Mrtfa	myocardin related transcription factor A	836	0.42
chr16_70562219_70562370	0.20	Gbe1	glucan (1,4-alpha-), branching enzyme 1	1300	0.56
chr7_37342624_37344008	0.20	6720469O03Rik	RIKEN cDNA 6720469O03 gene	23314	0.21
chr9_101006061_101006212	0.20	Pccb	propionyl Coenzyme A carboxylase, beta polypeptide	20527	0.15
chr15_54479454_54479605	0.20	Gm20070	predicted gene, 20070	8371	0.21
chr13_63571577_63571772	0.20	Ptch1	patched 1	1786	0.25
chr10_81903421_81903590	0.20	Zfp781	zinc finger protein 781	7394	0.1
chr10_6790825_6791573	0.20	Oprm1	opioid receptor, mu 1	2100	0.4
chr19_25060307_25061291	0.20	Dock8	dedicator of cytokinesis 8	8186	0.24
chr13_49609766_49610088	0.20	Ogn	osteoglycin	1881	0.26
chr2_102551752_102552240	0.20	Pamr1	peptidase domain containing associated with muscle regeneration 1	1847	0.45
chr13_3889296_3889648	0.20	Net1	neuroepithelial cell transforming gene 1	1647	0.26
chr15_6390004_6390155	0.20	Dab2	disabled 2, mitogen-responsive phosphoprotein	41	0.98
chr6_136080160_136080311	0.20	Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	91654	0.08
chr1_161879355_161879506	0.20	Suco	SUN domain containing ossification factor	2748	0.22
chr10_103145360_103145802	0.20	Lrriq1	leucine-rich repeats and IQ motif containing 1	794	0.68
chr17_33333481_33333632	0.20	Zfp81	zinc finger protein 81	25312	0.11
chr17_49309279_49309671	0.20	Gm17830	predicted gene, 17830	2766	0.26
chr5_106292155_106292306	0.20	Gm38433	predicted gene, 38433	20020	0.15
chr18_40259056_40260097	0.20	Kctd16	potassium channel tetramerisation domain containing 16	773	0.5
chr18_37652785_37653031	0.20	Gm8242	predicted gene 8242	1	0.91
chr13_118713631_118713983	0.20	Fgf10	fibroblast growth factor 10	892	0.52
chr3_131738069_131738640	0.20	Gm29865	predicted gene, 29865	21451	0.25
chr13_85926958_85927576	0.19	Gm46396	predicted gene, 46396	35525	0.19
chr7_89405888_89406433	0.19	Fzd4	frizzled class receptor 4	1805	0.24
chr5_106004428_106004686	0.19	Gm19566	predicted gene, 19566	23375	0.18
chr7_69490962_69491246	0.19	Gm38584	predicted gene, 38584	303	0.89
chr15_18819772_18819999	0.19	Cdh10	cadherin 10	444	0.76
chr12_107927728_107928847	0.19	Bcl11b	B cell leukemia/lymphoma 11B	75127	0.11
chr13_8205020_8205313	0.19	Adarb2	adenosine deaminase, RNA-specific, B2	2244	0.28

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd12

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.5	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.3	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.1	0.3	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.4	GO:0035564	regulation of kidney size(GO:0035564)
0.1	0.2	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.1	0.2	GO:0021776	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1	0.2	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1	0.2	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1	0.2	GO:0071798	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.2	GO:0021828	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1	0.3	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1	0.2	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1	0.2	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1	0.1	GO:0070384	Harderian gland development(GO:0070384)
0.1	0.2	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.2	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.1	GO:0060166	olfactory pit development(GO:0060166)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.3	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.2	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.2	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
0.0	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.2	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.1	GO:0060618	nipple development(GO:0060618)
0.0	0.3	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.2	GO:0061588	calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.0	0.1	GO:0060671	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0	0.1	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.1	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.0	0.1	GO:1900377	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.1	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.2	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.0	0.1	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.1	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.2	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.0	0.1	GO:0035880	embryonic nail plate morphogenesis(GO:0035880)
0.0	0.1	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.1	GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.1	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.0	0.1	GO:0090274	positive regulation of somatostatin secretion(GO:0090274)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.1	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.2	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.1	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.1	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	0.1	GO:0061156	pulmonary artery morphogenesis(GO:0061156)
0.0	0.1	GO:0060282	positive regulation of oocyte development(GO:0060282)
0.0	0.2	GO:0036315	cellular response to sterol(GO:0036315)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:1902455	negative regulation of stem cell population maintenance(GO:1902455)
0.0	0.1	GO:0014707	branchiomeric skeletal muscle development(GO:0014707)
0.0	0.1	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.0	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0	0.1	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.1	GO:0048682	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0	0.1	GO:1901979	regulation of inward rectifier potassium channel activity(GO:1901979)
0.0	0.1	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.1	GO:0060363	cranial suture morphogenesis(GO:0060363)
0.0	0.1	GO:0061042	vascular wound healing(GO:0061042)
0.0	0.1	GO:0045213	neurotransmitter receptor metabolic process(GO:0045213)
0.0	0.1	GO:0072017	distal tubule development(GO:0072017)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.2	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.0	GO:0072198	mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199)
0.0	0.0	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0	0.0	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.0	0.0	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0	0.2	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:0060754	positive regulation of mast cell chemotaxis(GO:0060754)
0.0	0.2	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.2	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0034441	plasma lipoprotein particle oxidation(GO:0034441)
0.0	0.1	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.0	0.2	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0090394	negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.1	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.2	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0	0.0	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.1	GO:0018002	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.1	GO:0042628	mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.0	0.0	GO:0086028	bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0	0.0	GO:1904177	regulation of adipose tissue development(GO:1904177)
0.0	0.0	GO:0042701	progesterone secretion(GO:0042701)
0.0	0.0	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.0	0.1	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0	0.0	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.0	0.0	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.0	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0036506	maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0	0.1	GO:1903012	positive regulation of bone development(GO:1903012)
0.0	0.1	GO:0046654	tetrahydrofolate biosynthetic process(GO:0046654)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.0	GO:0051794	regulation of catagen(GO:0051794)
0.0	0.1	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.3	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.0	GO:0060126	somatotropin secreting cell differentiation(GO:0060126)
0.0	0.1	GO:0044789	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0	0.1	GO:0035641	locomotory exploration behavior(GO:0035641)
0.0	0.1	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0	0.0	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.1	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.0	GO:0072051	juxtaglomerular apparatus development(GO:0072051)
0.0	0.0	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0001927	exocyst assembly(GO:0001927)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.1	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.0	0.1	GO:2001171	positive regulation of ATP biosynthetic process(GO:2001171)
0.0	0.2	GO:2000463	positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0002692	negative regulation of cellular extravasation(GO:0002692)
0.0	0.0	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0	0.0	GO:0003104	positive regulation of glomerular filtration(GO:0003104)
0.0	0.0	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.0	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.0	GO:2001197	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.0	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.0	0.2	GO:0032967	positive regulation of collagen biosynthetic process(GO:0032967)
0.0	0.1	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0	0.0	GO:0098910	regulation of atrial cardiac muscle cell action potential(GO:0098910)
0.0	0.1	GO:0035988	chondrocyte proliferation(GO:0035988)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.0	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.0	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:0090261	positive regulation of inclusion body assembly(GO:0090261)
0.0	0.0	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:1903276	regulation of sodium ion export(GO:1903273) positive regulation of sodium ion export(GO:1903275) regulation of sodium ion export from cell(GO:1903276) positive regulation of sodium ion export from cell(GO:1903278)
0.0	0.2	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.1	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.1	GO:0061032	visceral serous pericardium development(GO:0061032)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.2	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.0	GO:0070671	response to interleukin-12(GO:0070671)
0.0	0.1	GO:0050942	positive regulation of developmental pigmentation(GO:0048087) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.0	GO:0061370	testosterone biosynthetic process(GO:0061370)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0061743	motor learning(GO:0061743)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.2	GO:0001674	female germ cell nucleus(GO:0001674)
0.0	0.0	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:1990393	3M complex(GO:1990393)
0.0	0.3	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.2	GO:0060091	kinocilium(GO:0060091)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0097542	ciliary tip(GO:0097542)
0.0	0.1	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.1	GO:0071953	elastic fiber(GO:0071953)
0.0	0.3	GO:0001527	microfibril(GO:0001527)
0.0	0.4	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.2	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.0	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.1	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.2	GO:0043194	axon initial segment(GO:0043194)
0.0	0.3	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.0	GO:0005914	spot adherens junction(GO:0005914)
0.0	0.4	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.0	GO:0046691	intracellular canaliculus(GO:0046691)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0005655	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.2	GO:0005921	gap junction(GO:0005921)
0.0	0.0	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.2	GO:0097440	apical dendrite(GO:0097440)
0.0	0.5	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.0	GO:0043511	inhibin complex(GO:0043511)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:1990716	axonemal central apparatus(GO:1990716)
0.0	0.0	GO:0097512	cardiac myofibril(GO:0097512)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.3	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.1	0.4	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	0.3	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.2	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.4	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.2	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.1	GO:0048030	disaccharide binding(GO:0048030)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.2	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.2	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.0	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.3	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.2	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.2	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0043912	D-lysine oxidase activity(GO:0043912)
0.0	0.1	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.5	GO:0052715	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.2	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.0	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:1990189	peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0	0.1	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.2	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.0	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.2	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.0	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.0	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.0	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.2	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.2	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.2	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.1	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0	0.0	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.0	0.0	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.0	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.0	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.0	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.0	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.0	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.5	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.3	ST G ALPHA I PATHWAY	G alpha i Pathway
0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.4	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.3	REACTOME GAP JUNCTION TRAFFICKING	Genes involved in Gap junction trafficking
0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	REACTOME INFLUENZA LIFE CYCLE	Genes involved in Influenza Life Cycle
0.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease

Results for Hoxd12

Z-value: 0.50

Motif logo

Transcription factors associated with Hoxd12

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Hoxd12 motif across conditions

Conditions sorted by the z-value of the Hoxd12 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: