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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Klf13

Z-value: 0.73

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Transcription factors associated with Klf13

Gene Symbol	Gene ID	Gene Info
Klf13 Ensembl NCBI MGI UniProt	ENSMUSG00000052040.9	Kruppel-like factor 13

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr7_63931803_63931954	Klf13	4423	0.152193	-0.30	1.9e-02	Click!
chr7_63937849_63938852	Klf13	565	0.672893	-0.30	1.9e-02	Click!
chr7_63934435_63935180	Klf13	1494	0.304406	-0.30	2.1e-02	Click!
chr7_63941200_63941688	Klf13	2529	0.196957	0.25	5.6e-02	Click!
chr7_63941730_63941881	Klf13	2890	0.181158	0.21	1.1e-01	Click!

Activity of the Klf13 motif across conditions

Conditions sorted by the z-value of the Klf13 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_139020697_139021233	10.52	Gm45613	predicted gene 45613	34	0.98
chr8_71558187_71559532	1.72	Tmem221	transmembrane protein 221	12	0.94
chr13_60737782_60738368	1.56	Dapk1	death associated protein kinase 1	15921	0.15
chr3_41522196_41522994	1.53	2400006E01Rik	RIKEN cDNA 2400006E01 gene	622	0.65
chr15_80598900_80599687	1.50	Grap2	GRB2-related adaptor protein 2	24190	0.13
chr14_63164156_63165244	1.43	Fdft1	farnesyl diphosphate farnesyl transferase 1	225	0.91
chr17_56663591_56664733	1.40	Ranbp3	RAN binding protein 3	9132	0.11
chr17_56424927_56425952	1.38	Ptprs	protein tyrosine phosphatase, receptor type, S	22	0.97
chr6_119416453_119417745	1.35	Adipor2	adiponectin receptor 2	376	0.88
chrX_137118132_137120673	1.30	Esx1	extraembryonic, spermatogenesis, homeobox 1	769	0.36
chr10_80319682_80319974	1.28	2310011J03Rik	RIKEN cDNA 2310011J03 gene	709	0.38
chr8_104042374_104042662	1.23	Gm8748	predicted gene 8748	28631	0.16
chr5_74703847_74705020	1.19	Gm15984	predicted gene 15984	1413	0.31
chr2_72242133_72242510	1.18	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	27	0.97
chr12_117447118_117447786	1.18	Rapgef5	Rap guanine nucleotide exchange factor (GEF) 5	69027	0.12
chr2_163356404_163356958	1.17	Tox2	TOX high mobility group box family member 2	36303	0.11
chr6_51193157_51193734	1.16	Mir148a	microRNA 148a	76465	0.1
chr7_19180970_19181875	1.15	Mir330	microRNA 330	43	0.54
chr9_65128098_65129057	1.13	Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	12612	0.13
chr17_29841641_29842774	1.06	Mdga1	MAM domain containing glycosylphosphatidylinositol anchor 1	214	0.93
chr4_141041263_141041822	1.05	Crocc	ciliary rootlet coiled-coil, rootletin	12119	0.11
chr5_72224662_72225245	1.05	Atp10d	ATPase, class V, type 10D	21600	0.17
chr7_45515256_45516241	1.03	Tulp2	tubby-like protein 2	60	0.91
chr2_135536052_135537171	1.02	9630028H03Rik	RIKEN cDNA 9630028H03 gene	46685	0.17
chr2_28369440_28369591	1.00	Gm13373	predicted gene 13373	45465	0.12
chr7_135863729_135863975	1.00	Gm45241	predicted gene 45241	9404	0.16
chr15_75708830_75709401	1.00	Rhpn1	rhophilin, Rho GTPase binding protein 1	1624	0.26
chr15_101221041_101222412	0.98	AU021063	expressed sequence AU021063	479	0.63
chr15_76242501_76243437	0.98	Parp10	poly (ADP-ribose) polymerase family, member 10	451	0.59
chr19_56474746_56475273	0.97	Plekhs1	pleckstrin homology domain containing, family S member 1	3892	0.23
chr10_44038032_44038602	0.96	Crybg1	crystallin beta-gamma domain containing 1	20461	0.18
chr7_45800366_45800681	0.95	Cyth2	cytohesin 2	10365	0.07
chr10_61491946_61492200	0.93	Gm47595	predicted gene, 47595	4217	0.12
chr16_44015370_44016774	0.92	Gramd1c	GRAM domain containing 1C	364	0.83
chr1_195091807_195092906	0.92	Cd46	CD46 antigen, complement regulatory protein	107	0.94
chr11_69964787_69965749	0.89	Cldn7	claudin 7	128	0.87
chr2_29546441_29547087	0.89	Med27	mediator complex subunit 27	41893	0.12
chr8_70477508_70477693	0.88	Klhl26	kelch-like 26	632	0.51
chr7_27449664_27449998	0.88	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	1770	0.18
chr3_96102132_96102636	0.87	Otud7b	OTU domain containing 7B	2143	0.17
chr13_98689529_98690460	0.85	Tmem171	transmembrane protein 171	4774	0.15
chr8_120508825_120510253	0.84	Gm26971	predicted gene, 26971	11076	0.13
chr14_76585926_76586134	0.84	Serp2	stress-associated endoplasmic reticulum protein family member 2	29141	0.16
chr4_124899678_124899829	0.82	Epha10	Eph receptor A10	351	0.78
chr7_15954786_15955942	0.82	Nop53	NOP53 ribosome biogenesis factor	9290	0.1
chr10_93833520_93834579	0.81	Usp44	ubiquitin specific peptidase 44	231	0.91
chr5_118482858_118484042	0.81	Gm15754	predicted gene 15754	3517	0.25
chr16_90739931_90740383	0.80	Mrap	melanocortin 2 receptor accessory protein	1833	0.28
chr7_45340898_45341049	0.80	Ppfia3	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	187	0.83
chr11_117425952_117426103	0.80	Gm11732	predicted gene 11732	151	0.94
chr5_143924982_143925490	0.79	Gm42421	predicted gene, 42421	2939	0.15
chr4_152107258_152108639	0.79	Plekhg5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	219	0.89
chr12_24707675_24708235	0.79	Rrm2	ribonucleotide reductase M2	286	0.87
chr7_133114831_133116529	0.77	Ctbp2	C-terminal binding protein 2	2981	0.2
chr1_87270545_87271387	0.77	Efhd1os	EF hand domain containing 1, opposite strand	5792	0.12
chr8_94182622_94183855	0.77	Gm39228	predicted gene, 39228	51	0.95
chr1_136008028_136008415	0.76	Tmem9	transmembrane protein 9	71	0.95
chr9_109876011_109877009	0.75	Cdc25a	cell division cycle 25A	204	0.9
chr7_80156798_80157153	0.74	Gm45202	predicted gene 45202	1806	0.23
chr11_117175159_117175396	0.74	Sec14l1	SEC14-like lipid binding 1	20208	0.13
chr14_76149853_76150359	0.74	Nufip1	nuclear fragile X mental retardation protein interacting protein 1	39215	0.15
chr2_32750921_32752008	0.73	Tor2a	torsin family 2, member A	5770	0.08
chr14_65149139_65150455	0.73	Extl3	exostosin-like glycosyltransferase 3	58	0.97
chr9_20990858_20991262	0.73	Mrpl4	mitochondrial ribosomal protein L4	11678	0.07
chr10_120061270_120061896	0.72	Helb	helicase (DNA) B	30626	0.18
chr19_43584864_43585184	0.72	Gm34636	predicted gene, 34636	11667	0.11
chr9_107288899_107290229	0.70	Mapkapk3	mitogen-activated protein kinase-activated protein kinase 3	183	0.89
chr17_13668170_13669126	0.70	2700054A10Rik	RIKEN cDNA 2700054A10 gene	243	0.9
chr13_58007872_58008023	0.69	Mir874	microRNA 874	15253	0.21
chr4_155468952_155469786	0.69	Tmem52	transmembrane protein 52	222	0.87
chr1_165763123_165763707	0.68	Creg1	cellular repressor of E1A-stimulated genes 1	331	0.77
chr17_47802972_47803123	0.68	Tfeb	transcription factor EB	13606	0.12
chr2_93461586_93463194	0.68	Cd82	CD82 antigen	4	0.98
chr15_83496013_83496555	0.67	Ttll1	tubulin tyrosine ligase-like 1	14509	0.12
chr1_182585252_182585888	0.67	Capn8	calpain 8	20532	0.16
chr14_75069008_75069423	0.67	Rubcnl	RUN and cysteine rich domain containing beclin 1 interacting protein like	32593	0.14
chr3_39219846_39220607	0.65	Gm43008	predicted gene 43008	2380	0.41
chr1_134747452_134748117	0.65	Syt2	synaptotagmin II	793	0.59
chr10_43666883_43667818	0.65	Gm34481	predicted gene, 34481	8032	0.13
chr2_163823554_163824237	0.65	Ccn5	cellular communication network factor 5	3006	0.24
chr10_81168389_81168622	0.65	Pias4	protein inhibitor of activated STAT 4	582	0.47
chr17_47909108_47910390	0.64	Gm15556	predicted gene 15556	12629	0.13
chr1_160746842_160746993	0.63	Gm38126	predicted gene, 38126	8770	0.12
chr6_142788560_142788823	0.63	Sult6b2	sulfotransferase family 6B, member 2	15775	0.16
chr15_99113363_99113593	0.63	Spats2	spermatogenesis associated, serine-rich 2	12438	0.09
chr8_94781701_94782201	0.63	Cx3cl1	chemokine (C-X3-C motif) ligand 1	9726	0.11
chr13_112439365_112440345	0.62	Gm48879	predicted gene, 48879	3259	0.19
chr16_90400287_90400987	0.62	Hunk	hormonally upregulated Neu-associated kinase	93	0.97
chr7_49496645_49497633	0.62	Gm38059	predicted gene, 38059	27427	0.2
chr11_59786838_59787832	0.61	Pld6	phospholipase D family, member 6	307	0.8
chr9_114527981_114528394	0.61	C130032M10Rik	RIKEN cDNA C130032M10 gene	12490	0.16
chr8_117335167_117335696	0.61	Cmip	c-Maf inducing protein	13739	0.25
chr5_122059493_122060141	0.60	Cux2	cut-like homeobox 2	9715	0.14
chr2_167343559_167343841	0.59	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	5483	0.21
chr4_138469035_138469593	0.58	Camk2n1	calcium/calmodulin-dependent protein kinase II inhibitor 1	15000	0.15
chr4_132796191_132796588	0.58	Themis2	thymocyte selection associated family member 2	2	0.96
chr2_168158942_168159659	0.58	E130018N17Rik	RIKEN cDNA E130018N17 gene	4787	0.13
chr11_119237747_119238894	0.57	Ccdc40	coiled-coil domain containing 40	398	0.77
chr11_117475760_117476250	0.56	Gm34418	predicted gene, 34418	6592	0.15
chr11_78435586_78436201	0.55	Gm11195	predicted gene 11195	8214	0.09
chr19_29325359_29325923	0.55	Insl6	insulin-like 6	285	0.88
chr9_120581966_120582700	0.55	Gm47062	predicted gene, 47062	2198	0.19
chr13_23317523_23318359	0.54	4930586N03Rik	RIKEN cDNA 4930586N03 gene	4416	0.1
chr14_54958124_54958655	0.54	Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	482	0.52
chr9_107526345_107527662	0.53	Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	346	0.68
chr11_34031937_34032124	0.53	Lcp2	lymphocyte cytosolic protein 2	14890	0.2
chr19_10421963_10422290	0.53	Gm50268	predicted gene, 50268	17771	0.13
chr15_84450356_84451064	0.52	Shisal1	shisa like 1	3613	0.28
chr13_92593987_92594157	0.52	Serinc5	serine incorporator 5	17019	0.18
chr7_98158554_98158943	0.52	Capn5	calpain 5	3462	0.18
chr17_47737108_47738630	0.52	Tfeb	transcription factor EB	59	0.95
chr14_20452251_20452547	0.52	Cfap70	cilia and flagella associated protein 70	173	0.92
chr9_44515217_44515909	0.52	Cxcr5	chemokine (C-X-C motif) receptor 5	10858	0.07
chr2_30985262_30985875	0.52	Usp20	ubiquitin specific peptidase 20	3139	0.16
chr5_101665386_101665820	0.51	Nkx6-1	NK6 homeobox 1	607	0.74
chr12_108004788_108005664	0.51	Bcl11b	B cell leukemia/lymphoma 11B	1624	0.51
chr13_13358078_13358229	0.51	Gpr137b	G protein-coupled receptor 137B	9652	0.11
chrX_20659340_20659491	0.51	Uba1	ubiquitin-like modifier activating enzyme 1	12	0.97
chr3_33955028_33955284	0.51	4930502C17Rik	RIKEN cDNA 4930502C17 gene	1044	0.44
chr2_73589836_73590674	0.50	Chrna1os	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle), opposite strand	5395	0.15
chr10_80569426_80569836	0.50	Klf16	Kruppel-like factor 16	7690	0.08
chr6_90989200_90989476	0.50	Iqsec1	IQ motif and Sec7 domain 1	653	0.72
chr7_99827539_99828752	0.50	Neu3	neuraminidase 3	272	0.86
chr7_45797605_45798943	0.49	Lmtk3	lemur tyrosine kinase 3	10526	0.07
chr4_43493224_43493378	0.49	Ccdc107	coiled-coil domain containing 107	61	0.71
chr10_42715047_42716006	0.46	Gm15200	predicted gene 15200	17008	0.16
chr5_144357138_144358729	0.45	Dmrt1i	Dmrt1 interacting ncRNA	10	0.7
chr16_10357804_10358541	0.45	Gm1600	predicted gene 1600	10581	0.15
chr15_36647405_36647556	0.45	Gm6704	predicted gene 6704	17611	0.12
chr2_57102068_57103416	0.45	Nr4a2	nuclear receptor subfamily 4, group A, member 2	10330	0.2
chr15_11741805_11742688	0.45	Gm41271	predicted gene, 41271	38543	0.18
chr17_34093589_34094165	0.45	BC051537	cDNA sequence BC051537	1405	0.13
chr5_123171494_123172535	0.44	Hpd	4-hydroxyphenylpyruvic acid dioxygenase	897	0.35
chr2_180642344_180643352	0.44	Tcfl5	transcription factor-like 5 (basic helix-loop-helix)	140	0.94
chr11_117685805_117686516	0.44	Tnrc6c	trinucleotide repeat containing 6C	31347	0.13
chr14_58383123_58383274	0.44	Gm33321	predicted gene, 33321	82216	0.1
chr13_37508920_37510039	0.43	Gm29590	predicted gene 29590	239	0.85
chr7_45437080_45437256	0.43	Ruvbl2	RuvB-like protein 2	928	0.24
chr8_120693953_120694425	0.42	Gm33142	predicted gene, 33142	8790	0.11
chr17_56818209_56818531	0.42	Rfx2	regulatory factor X, 2 (influences HLA class II expression)	12569	0.12
chr1_135778673_135779502	0.42	Tnni1	troponin I, skeletal, slow 1	347	0.84
chr5_106470004_106471103	0.42	Gm26872	predicted gene, 26872	454	0.81
chr17_24657836_24658944	0.42	Npw	neuropeptide W	67	0.92
chr2_170154822_170155722	0.41	Zfp217	zinc finger protein 217	7169	0.29
chr2_32083168_32084169	0.41	Fam78a	family with sequence similarity 78, member A	115	0.94
chr15_100636108_100637173	0.41	Smagp	small cell adhesion glycoprotein	51	0.94
chr10_81380285_81380531	0.41	Fzr1	fizzy and cell division cycle 20 related 1	1892	0.11
chr7_25619112_25619835	0.41	Dmac2	distal membrane arm assembly complex 2	20	0.94
chr7_18962222_18963745	0.40	Nanos2	nanos C2HC-type zinc finger 2	24417	0.07
chr4_32834117_32834411	0.40	Ankrd6	ankyrin repeat domain 6	11463	0.18
chr7_29118392_29118870	0.40	Ryr1	ryanodine receptor 1, skeletal muscle	6384	0.09
chr15_82293133_82293794	0.40	Wbp2nl	WBP2 N-terminal like	5491	0.09
chr16_30512552_30512703	0.39	Tmem44	transmembrane protein 44	28282	0.16
chr17_56756624_56758021	0.39	Nrtn	neurturin	208	0.88
chr5_41763315_41764785	0.39	Nkx3-2	NK3 homeobox 2	451	0.86
chr11_69326020_69327207	0.39	Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	355	0.68
chr7_145302223_145303241	0.39	Mrgprf	MAS-related GPR, member F	1833	0.35
chr2_119334790_119335432	0.39	Dll4	delta like canonical Notch ligand 4	6573	0.13
chr11_74536337_74536639	0.39	Rap1gap2	RAP1 GTPase activating protein 2	13737	0.2
chr17_46620556_46620966	0.39	Ptk7	PTK7 protein tyrosine kinase 7	8743	0.1
chr9_64022235_64023090	0.39	Smad6	SMAD family member 6	603	0.67
chr10_45291931_45292275	0.38	Gm15934	predicted gene 15934	2679	0.18
chr7_16313330_16314024	0.38	Bbc3	BCL2 binding component 3	160	0.92
chr8_71665120_71666309	0.38	Unc13a	unc-13 homolog A	2368	0.14
chr7_44350602_44354420	0.38	Shank1	SH3 and multiple ankyrin repeat domains 1	1749	0.15
chr10_67126563_67127770	0.38	Jmjd1c	jumonji domain containing 1C	92	0.97
chr13_95524182_95525409	0.38	F2rl1	coagulation factor II (thrombin) receptor-like 1	432	0.8
chr11_99131599_99132803	0.38	Ccr7	chemokine (C-C motif) receptor 7	22876	0.13
chr16_17619128_17619354	0.37	Smpd4	sphingomyelin phosphodiesterase 4	113	0.94
chr7_30183828_30184670	0.37	Cox7a1	cytochrome c oxidase subunit 7A1	55	0.92
chr4_140770313_140770939	0.37	Padi4	peptidyl arginine deiminase, type IV	3610	0.16
chr6_118593001_118594277	0.37	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	1787	0.35
chr7_49350531_49350896	0.36	Gm44913	predicted gene 44913	4619	0.25
chr17_49900579_49901205	0.36	Gm16554	predicted gene 16554	4925	0.2
chr5_100353191_100353824	0.36	Gm8091	predicted gene 8091	1612	0.36
chr8_70630745_70631808	0.36	Gdf15	growth differentiation factor 15	819	0.39
chr11_47377104_47378325	0.36	Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	1808	0.52
chr13_62857070_62857298	0.36	Fbp2	fructose bisphosphatase 2	875	0.48
chr2_158153509_158154452	0.36	Tgm2	transglutaminase 2, C polypeptide	7544	0.16
chr18_82906600_82906751	0.35	Zfp516	zinc finger protein 516	3988	0.17
chr8_70329770_70331438	0.35	Gdf1	growth differentiation factor 1	787	0.45
chr11_117836263_117836628	0.35	Afmid	arylformamidase	4172	0.1
chr10_119614719_119615429	0.35	Gm47027	predicted gene, 47027	2646	0.29
chr10_61906333_61906511	0.35	Col13a1	collagen, type XIII, alpha 1	28030	0.17
chr7_29318511_29319550	0.34	Gm44632	predicted gene 44632	372	0.77
chr11_120350589_120350893	0.34	0610009L18Rik	RIKEN cDNA 0610009L18 gene	2063	0.13
chr12_111943340_111944555	0.34	5033406O09Rik	RIKEN cDNA 5033406O09 gene	199	0.89
chr6_120187572_120188939	0.34	Ninj2	ninjurin 2	5568	0.22
chr10_39501612_39501987	0.33	Fyn	Fyn proto-oncogene	9940	0.21
chr1_133168432_133168872	0.33	Plekha6	pleckstrin homology domain containing, family A member 6	4442	0.19
chr18_84070282_84070920	0.33	Tshz1	teashirt zinc finger family member 1	14474	0.16
chr3_108558558_108558709	0.32	Gm43435	predicted gene 43435	3166	0.1
chr3_149076913_149077569	0.32	Gm25127	predicted gene, 25127	48309	0.14
chr12_105705647_105706505	0.32	Ak7	adenylate kinase 7	100	0.96
chr17_45526364_45526864	0.32	Tcte1	t-complex-associated testis expressed 1	3180	0.13
chr13_98968150_98968301	0.32	Gm47052	predicted gene, 47052	5153	0.13
chr2_167538066_167539536	0.32	Snai1	snail family zinc finger 1	606	0.61
chr11_35838085_35838789	0.32	Rars	arginyl-tRNA synthetase	3931	0.2
chr18_63859767_63860372	0.31	Gm19076	predicted gene, 19076	38962	0.15
chr11_108222674_108223259	0.31	Gm11655	predicted gene 11655	41116	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf13

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0043382	positive regulation of memory T cell differentiation(GO:0043382)
0.3	1.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.2	0.7	GO:0000087	mitotic M phase(GO:0000087)
0.2	1.2	GO:0061042	vascular wound healing(GO:0061042)
0.2	0.6	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.2	1.3	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.2	0.9	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.2	1.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.2	0.8	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1	0.4	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.1	0.8	GO:0032463	negative regulation of protein homooligomerization(GO:0032463)
0.1	0.4	GO:1900740	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1	0.3	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.1	0.8	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1	0.6	GO:0044351	macropinocytosis(GO:0044351)
0.1	0.3	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174)
0.1	0.4	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.1	0.3	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.1	0.5	GO:0010635	regulation of mitochondrial fusion(GO:0010635)
0.1	0.2	GO:0046149	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	0.2	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.1	0.2	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1	0.3	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.1	0.2	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.1	0.4	GO:0006689	ganglioside catabolic process(GO:0006689)
0.1	0.2	GO:0072051	juxtaglomerular apparatus development(GO:0072051)
0.1	0.4	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.1	0.2	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.1	0.4	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.1	0.2	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.1	0.2	GO:0021564	vagus nerve development(GO:0021564)
0.1	0.4	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.1	0.2	GO:1903849	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1	0.3	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.1	0.2	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.1	0.1	GO:0061031	endodermal digestive tract morphogenesis(GO:0061031)
0.1	0.1	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.1	GO:0021538	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.0	1.1	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.7	GO:0015012	heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0	0.2	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.2	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.2	GO:0018101	protein citrullination(GO:0018101)
0.0	0.2	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.2	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.4	GO:0014883	transition between fast and slow fiber(GO:0014883)
0.0	0.1	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0	0.2	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.2	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.3	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:1904222	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.1	GO:0035912	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0	0.2	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.7	GO:0035767	endothelial cell chemotaxis(GO:0035767)
0.0	0.1	GO:0061641	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0	0.1	GO:0044857	plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0	0.3	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.1	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.1	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	0.2	GO:0006555	methionine metabolic process(GO:0006555)
0.0	0.5	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.0	0.0	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.5	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.1	GO:0018211	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.2	GO:0010820	positive regulation of T cell chemotaxis(GO:0010820)
0.0	0.3	GO:0003351	epithelial cilium movement(GO:0003351)
0.0	0.1	GO:0042519	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519)
0.0	0.1	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.1	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.1	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.1	GO:0071899	regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0	0.0	GO:0048320	axial mesoderm formation(GO:0048320)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.3	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.2	GO:0060352	cell adhesion molecule production(GO:0060352)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.0	GO:2000667	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.1	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.1	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.2	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.2	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0	0.2	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)
0.0	0.1	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.1	GO:2001137	positive regulation of endocytic recycling(GO:2001137)
0.0	0.1	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:1902416	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.0	GO:0015755	fructose transport(GO:0015755)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0	0.0	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.1	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.0	GO:0060339	negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.0	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.0	GO:0046103	inosine biosynthetic process(GO:0046103)
0.0	0.1	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.1	GO:0046959	habituation(GO:0046959)
0.0	0.1	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.0	0.1	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.0	GO:0032460	negative regulation of protein oligomerization(GO:0032460)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0033122	negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0	0.2	GO:0043574	protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0	0.1	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0060213	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.1	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.0	GO:0002086	diaphragm contraction(GO:0002086)
0.0	0.1	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.7	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:1902547	regulation of vascular endothelial growth factor signaling pathway(GO:1900746) regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902547)
0.0	0.0	GO:0007223	Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0	0.0	GO:1904179	positive regulation of adipose tissue development(GO:1904179)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0060931	sinoatrial node cell development(GO:0060931)
0.0	0.8	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.1	GO:0030220	platelet formation(GO:0030220)
0.0	0.0	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0	0.1	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.0	0.0	GO:1901725	regulation of histone deacetylase activity(GO:1901725)
0.0	0.0	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0042693	muscle cell fate commitment(GO:0042693)
0.0	0.0	GO:0002225	positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.0	GO:0001765	membrane raft assembly(GO:0001765)
0.0	0.4	GO:0050873	brown fat cell differentiation(GO:0050873)
0.0	0.0	GO:0033483	gas homeostasis(GO:0033483)
0.0	0.0	GO:0072053	renal inner medulla development(GO:0072053)
0.0	0.0	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.0	GO:0070126	mitochondrial translational termination(GO:0070126)
0.0	0.1	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.0	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.0	0.0	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.0	0.1	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	0.0	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.1	GO:0044316	cone cell pedicle(GO:0044316)
0.2	0.7	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2	0.9	GO:0002079	inner acrosomal membrane(GO:0002079)
0.1	0.2	GO:0071953	elastic fiber(GO:0071953)
0.0	0.4	GO:0005861	troponin complex(GO:0005861)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.7	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0044194	cytolytic granule(GO:0044194)
0.0	0.5	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.1	GO:1990393	3M complex(GO:1990393)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.3	GO:0005859	muscle myosin complex(GO:0005859)
0.0	0.3	GO:0036128	CatSper complex(GO:0036128)
0.0	0.3	GO:0031143	pseudopodium(GO:0031143)
0.0	0.2	GO:0097470	ribbon synapse(GO:0097470)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	1.0	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.3	GO:0098827	endoplasmic reticulum subcompartment(GO:0098827)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.1	GO:0071547	piP-body(GO:0071547)
0.0	0.2	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.1	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.2	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.4	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:1990357	terminal web(GO:1990357)
0.0	0.3	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.3	GO:0001673	male germ cell nucleus(GO:0001673)
0.0	0.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.0	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.0	GO:0000811	GINS complex(GO:0000811)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.4	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	0.3	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.0	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.0	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0097255	R2TP complex(GO:0097255)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:0055100	adiponectin binding(GO:0055100)
0.2	0.7	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2	1.3	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.1	0.4	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	0.5	GO:0008808	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.1	0.5	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	0.4	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1	0.3	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	0.3	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.1	0.3	GO:0004127	cytidylate kinase activity(GO:0004127)
0.1	0.2	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.1	0.3	GO:0015057	thrombin receptor activity(GO:0015057)
0.1	0.3	GO:0061665	SUMO ligase activity(GO:0061665)
0.1	0.2	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.2	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1	0.2	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.4	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.9	GO:0001848	complement binding(GO:0001848)
0.0	0.8	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0	0.2	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.2	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.7	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.3	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.5	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.2	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.0	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0032138	single base insertion or deletion binding(GO:0032138)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.2	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.1	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	1.6	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	0.2	GO:0005542	folic acid binding(GO:0005542)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.3	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.3	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	1.7	GO:0005088	Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0	0.0	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.2	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.0	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.4	GO:0043734	DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.0	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.0	0.2	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	0.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.0	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.2	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.0	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.4	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.1	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.2	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.6	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.5	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.1	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.2	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	1.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	0.7	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1	1.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.6	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.6	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.4	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.0	0.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.3	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.0	REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	Genes involved in Downstream signaling of activated FGFR
0.0	0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.1	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.1	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis

Results for Klf13

Z-value: 0.73

Motif logo

Transcription factors associated with Klf13

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Klf13 motif across conditions

Conditions sorted by the z-value of the Klf13 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf13

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: