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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Klf3

Z-value: 0.58

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Transcription factors associated with Klf3

Gene Symbol	Gene ID	Gene Info
Klf3 Ensembl NCBI MGI UniProt	ENSMUSG00000029178.8	Klf3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Klf3	chr5_64809367_64809770	2771	0.207271	0.29	2.4e-02	Click!
Klf3	chr5_64802596_64803261	460	0.576944	-0.26	4.9e-02	Click!
Klf3	chr5_64809804_64809955	2460	0.224155	0.25	5.1e-02	Click!
Klf3	chr5_64813848_64814093	1586	0.322668	0.24	7.0e-02	Click!
Klf3	chr5_64781139_64781290	22174	0.133905	0.14	2.7e-01	Click!

Activity of the Klf3 motif across conditions

Conditions sorted by the z-value of the Klf3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_102360845_102363484	1.22	Slc4a1	solute carrier family 4 (anion exchanger), member 1	1540	0.24
chr4_155893812_155895517	1.20	Acap3	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	2352	0.11
chr11_90677181_90677343	1.16	Tom1l1	target of myb1-like 1 (chicken)	10317	0.2
chr18_67573133_67573367	1.05	Gm17669	predicted gene, 17669	10856	0.17
chr16_23058440_23059079	0.99	Kng1	kininogen 1	366	0.69
chr2_74713120_74713846	0.91	Hoxd3os1	homeobox D3, opposite strand 1	957	0.21
chr17_56241459_56242409	0.77	A230051N06Rik	RIKEN cDNA A230051N06 gene	218	0.81
chr7_45047563_45050465	0.76	Prr12	proline rich 12	3867	0.07
chr19_47017426_47018238	0.75	Nt5c2	5'-nucleotidase, cytosolic II	2679	0.17
chr17_48450856_48451498	0.75	Tspo2	translocator protein 2	315	0.83
chr14_66344363_66345813	0.72	Stmn4	stathmin-like 4	707	0.65
chr10_127167223_127168270	0.69	B4galnt1	beta-1,4-N-acetyl-galactosaminyl transferase 1	1887	0.15
chr11_102364387_102365146	0.67	Slc4a1	solute carrier family 4 (anion exchanger), member 1	481	0.67
chr6_90551160_90552107	0.64	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	785	0.56
chr17_48272521_48272834	0.63	Treml4	triggering receptor expressed on myeloid cells-like 4	238	0.88
chr6_52229552_52230397	0.61	Mir196b	microRNA 196b	191	0.57
chr7_79502506_79503035	0.61	Mir9-3	microRNA 9-3	2494	0.13
chr2_27981777_27982295	0.61	Col5a1	collagen, type V, alpha 1	35405	0.15
chr1_130732649_130733832	0.60	AA986860	expressed sequence AA986860	1130	0.29
chr1_172894740_172894971	0.59	Apcs	serum amyloid P-component	186	0.93
chr17_88460455_88460676	0.57	Foxn2	forkhead box N2	19790	0.17
chr1_74949307_74952042	0.56	Ihh	Indian hedgehog	768	0.5
chr19_5842574_5845856	0.56	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	1044	0.25
chr11_6413239_6413536	0.56	Ppia	peptidylprolyl isomerase A	2056	0.17
chr7_101422402_101423202	0.55	Pde2a	phosphodiesterase 2A, cGMP-stimulated	956	0.45
chr13_54607077_54607512	0.55	Cltb	clathrin, light polypeptide (Lcb)	3998	0.12
chr5_139382341_139382984	0.54	Gpr146	G protein-coupled receptor 146	2081	0.2
chr7_27448641_27448983	0.53	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	751	0.39
chrX_7640827_7641363	0.53	Syp	synaptophysin	1334	0.21
chr6_83068298_83071797	0.52	Tlx2	T cell leukemia, homeobox 2	178	0.81
chr7_126702563_126704731	0.51	Coro1a	coronin, actin binding protein 1A	473	0.55
chr16_42275550_42276525	0.50	Gap43	growth associated protein 43	35	0.98
chr5_123150083_123151176	0.50	Setd1b	SET domain containing 1B	7672	0.08
chr17_85686512_85689764	0.49	Six2	sine oculis-related homeobox 2	116	0.96
chr5_124451141_124451723	0.49	Kmt5a	lysine methyltransferase 5A	261	0.84
chr7_19022230_19023942	0.49	Foxa3	forkhead box A3	452	0.57
chr2_127362687_127364202	0.49	Adra2b	adrenergic receptor, alpha 2b	158	0.94
chr13_43261355_43261506	0.48	Gfod1	glucose-fructose oxidoreductase domain containing 1	41975	0.15
chr17_78248797_78249192	0.48	Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	11222	0.18
chr15_100402856_100403333	0.47	Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	149	0.92
chr5_112345255_112345758	0.47	Hps4	HPS4, biogenesis of lysosomal organelles complex 3 subunit 2	2406	0.14
chr19_7421074_7423945	0.47	Mir6991	microRNA 6991	64	0.94
chr17_12378732_12379615	0.46	Plg	plasminogen	514	0.75
chr15_102976255_102978005	0.46	Hoxc9	homeobox C9	98	0.92
chr13_21776625_21776982	0.44	H1f5	H1.5 linker histone, cluster member	3822	0.06
chr4_152349775_152350796	0.44	Gm13645	predicted gene 13645	3356	0.16
chr9_74865733_74868961	0.44	Onecut1	one cut domain, family member 1	863	0.54
chr3_66486206_66486617	0.44	Gm17952	predicted gene, 17952	77140	0.1
chr19_6398611_6400187	0.44	Rasgrp2	RAS, guanyl releasing protein 2	57	0.93
chr2_24951893_24952139	0.43	Zmynd19	zinc finger, MYND domain containing 19	1806	0.16
chr17_27183697_27183996	0.43	Lemd2	LEM domain containing 2	9634	0.1
chrX_74426690_74427045	0.43	Ikbkg	inhibitor of kappaB kinase gamma	1035	0.31
chr16_91219818_91221532	0.42	Gm49614	predicted gene, 49614	2251	0.2
chr5_73246539_73246690	0.41	Fryl	FRY like transcription coactivator	9811	0.11
chr7_25674373_25675380	0.41	Tmem91	transmembrane protein 91	171	0.89
chr10_81024569_81025640	0.41	Gm16099	predicted gene 16099	21	0.8
chr10_81091601_81092278	0.41	Creb3l3	cAMP responsive element binding protein 3-like 3	33	0.94
chr2_102867441_102867713	0.41	Gm23731	predicted gene, 23731	30383	0.18
chr7_49398916_49399175	0.40	Nav2	neuron navigator 2	34324	0.18
chr5_22341020_22341652	0.40	Reln	reelin	3354	0.18
chr11_17007546_17008653	0.40	Plek	pleckstrin	603	0.7
chr4_125122525_125123430	0.40	Zc3h12a	zinc finger CCCH type containing 12A	457	0.77
chr15_75892413_75892732	0.40	Naprt	nicotinate phosphoribosyltransferase	4	0.94
chr11_84520959_84524590	0.40	Lhx1	LIM homeobox protein 1	63	0.97
chr18_64265796_64267074	0.39	St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	47	0.97
chr8_71700550_71701837	0.39	B3gnt3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	596	0.52
chr16_49775252_49775761	0.39	Gm15518	predicted gene 15518	23364	0.2
chr5_139211825_139211976	0.39	Sun1	Sad1 and UNC84 domain containing 1	41	0.97
chr11_77783639_77784980	0.39	Gm10277	predicted gene 10277	3438	0.18
chr8_123410787_123412789	0.38	Tubb3	tubulin, beta 3 class III	198	0.84
chr1_166130460_166130958	0.37	Gpa33	glycoprotein A33 (transmembrane)	242	0.91
chr2_121357946_121359451	0.37	Ckmt1	creatine kinase, mitochondrial 1, ubiquitous	32	0.95
chr10_95880189_95880470	0.36	Gm47724	predicted gene, 47724	9530	0.13
chr1_63655959_63656110	0.36	Gm12748	predicted gene 12748	15434	0.15
chr1_132384306_132384539	0.36	Gm15849	predicted gene 15849	3293	0.17
chr7_16275527_16275803	0.36	Ccdc9	coiled-coil domain containing 9	106	0.93
chr6_108659051_108660392	0.36	Bhlhe40	basic helix-loop-helix family, member e40	908	0.41
chr9_44396453_44399065	0.35	Slc37a4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	417	0.53
chr7_98493200_98493540	0.35	Lrrc32	leucine rich repeat containing 32	852	0.49
chr3_8509825_8511666	0.35	Stmn2	stathmin-like 2	1159	0.54
chr12_101026829_101027420	0.35	Ccdc88c	coiled-coil domain containing 88C	1785	0.23
chr10_128400690_128401219	0.35	Slc39a5	solute carrier family 39 (metal ion transporter), member 5	256	0.73
chr1_177411902_177412443	0.35	Gm26801	predicted gene, 26801	16912	0.17
chr5_130022581_130023074	0.35	Asl	argininosuccinate lyase	1473	0.28
chr11_99176689_99176840	0.35	Ccr7	chemokine (C-C motif) receptor 7	21687	0.13
chr13_112043719_112044107	0.35	Gm15323	predicted gene 15323	38411	0.15
chr2_26576075_26576641	0.34	Egfl7	EGF-like domain 7	3656	0.11
chr7_46396141_46398423	0.34	Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	366	0.84
chr4_155162564_155162715	0.34	Ski	ski sarcoma viral oncogene homolog (avian)	25657	0.14
chr2_153345876_153347096	0.34	2500004C02Rik	RIKEN cDNA 2500004C02 gene	413	0.6
chr19_45230983_45235468	0.34	Lbx1	ladybird homeobox 1	2587	0.27
chr11_96308497_96309471	0.34	Hoxb5os	homeobox B5 and homeobox B6, opposite strand	2074	0.12
chr4_62479845_62481162	0.33	Bspry	B-box and SPRY domain containing	414	0.75
chr1_120598097_120600876	0.33	En1	engrailed 1	2932	0.29
chr10_80879874_80880283	0.33	Tmprss9	transmembrane protease, serine 9	358	0.72
chr2_70921160_70921456	0.33	Gm13632	predicted gene 13632	43479	0.14
chr10_49779879_49781120	0.33	Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	2760	0.23
chr3_51518589_51518921	0.33	Setd7	SET domain containing (lysine methyltransferase) 7	17892	0.09
chr2_152085191_152085589	0.32	Scrt2	scratch family zinc finger 2	3861	0.17
chr8_121590486_121591687	0.32	Map1lc3b	microtubule-associated protein 1 light chain 3 beta	374	0.77
chr16_93366361_93366682	0.32	1810053B23Rik	RIKEN cDNA 1810053B23 gene	147	0.94
chr7_30531338_30531929	0.32	Arhgap33	Rho GTPase activating protein 33	1768	0.12
chr6_143832506_143833713	0.32	Sox5	SRY (sex determining region Y)-box 5	113979	0.06
chr5_123222744_123223261	0.31	Psmd9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	5188	0.12
chr12_16632574_16632725	0.31	Lpin1	lipin 1	14317	0.17
chr7_19082814_19086200	0.31	Dmpk	dystrophia myotonica-protein kinase	203	0.83
chr8_106336310_106337932	0.31	Smpd3	sphingomyelin phosphodiesterase 3, neutral	867	0.61
chr19_8709801_8709987	0.31	Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	3091	0.07
chr11_83850990_83852424	0.30	Hnf1b	HNF1 homeobox B	535	0.69
chr4_130171697_130173536	0.30	Tinagl1	tubulointerstitial nephritis antigen-like 1	2075	0.27
chr1_89467693_89468170	0.30	Agap1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	12675	0.19
chr3_146101204_146101488	0.29	Wdr63	WD repeat domain 63	6784	0.16
chr4_140584429_140584695	0.29	Arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like	219	0.94
chr14_54408224_54410842	0.29	Slc7a7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	73	0.94
chr13_110094155_110094306	0.29	Pde4d	phosphodiesterase 4D, cAMP specific	158918	0.04
chr17_36019108_36019278	0.29	H2-T24	histocompatibility 2, T region locus 24	1332	0.17
chr7_24369840_24369991	0.29	Kcnn4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	348	0.74
chr9_41156579_41157745	0.28	Ubash3b	ubiquitin associated and SH3 domain containing, B	340	0.82
chr6_136547141_136547342	0.28	Atf7ip	activating transcription factor 7 interacting protein	3946	0.19
chr5_88564689_88565985	0.28	Rufy3	RUN and FYVE domain containing 3	297	0.87
chr10_17651311_17651462	0.28	Gm47771	predicted gene, 47771	7127	0.25
chrX_161719845_161720465	0.28	Rai2	retinoic acid induced 2	2528	0.41
chr2_74692311_74693685	0.28	Hoxd10	homeobox D10	1074	0.19
chr11_16503427_16503928	0.28	Sec61g	SEC61, gamma subunit	1367	0.46
chr7_142474634_142476734	0.28	Lsp1	lymphocyte specific 1	690	0.52
chr2_31638722_31641540	0.27	Prdm12	PR domain containing 12	94	0.84
chr10_81145829_81146966	0.27	Zbtb7a	zinc finger and BTB domain containing 7a	8444	0.07
chr14_32600761_32600912	0.27	Prrxl1	paired related homeobox protein-like 1	878	0.56
chr2_158401974_158402125	0.27	Gm14201	predicted gene 14201	966	0.34
chr15_8967409_8968940	0.27	Ranbp3l	RAN binding protein 3-like	172	0.96
chr9_22049418_22049658	0.27	Elavl3	ELAV like RNA binding protein 3	2472	0.12
chr11_84519041_84519440	0.27	Lhx1	LIM homeobox protein 1	2827	0.25
chr2_66632905_66633478	0.27	Scn9a	sodium channel, voltage-gated, type IX, alpha	1462	0.53
chr16_31754278_31755029	0.27	Dlg1	discs large MAGUK scaffold protein 1	303	0.86
chr5_123201326_123201494	0.27	Gm43409	predicted gene 43409	9822	0.1
chr1_152807871_152808731	0.26	Ncf2	neutrophil cytosolic factor 2	323	0.86
chr11_61075424_61076210	0.26	Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	10013	0.17
chr17_28237484_28238264	0.26	Ppard	peroxisome proliferator activator receptor delta	5067	0.12
chr3_89386729_89388779	0.26	Zbtb7b	zinc finger and BTB domain containing 7B	83	0.91
chr7_35553510_35553693	0.26	Nudt19	nudix (nucleoside diphosphate linked moiety X)-type motif 19	1558	0.24
chr2_155992156_155992465	0.26	Cep250	centrosomal protein 250	6395	0.11
chr7_144238658_144240098	0.26	Shank2	SH3 and multiple ankyrin repeat domains 2	653	0.8
chr2_174283563_174287177	0.26	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	12	0.53
chr11_77892631_77894065	0.26	Pipox	pipecolic acid oxidase	748	0.58
chr6_118757785_118758013	0.26	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	75	0.98
chr14_70106795_70107014	0.25	Bin3	bridging integrator 3	6739	0.15
chrX_48204804_48205976	0.25	Zdhhc9	zinc finger, DHHC domain containing 9	2938	0.23
chr1_75212400_75213683	0.25	Stk16	serine/threonine kinase 16	20	0.92
chr11_74555781_74555954	0.25	Rap1gap2	RAP1 GTPase activating protein 2	33116	0.15
chr9_45202291_45202442	0.25	Tmprss4	transmembrane protease, serine 4	1620	0.23
chr10_39736016_39736307	0.25	Rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit	3797	0.16
chr7_25152042_25153378	0.25	D930028M14Rik	RIKEN cDNA D930028M14 gene	253	0.87
chr1_130731543_130732516	0.25	AA986860	expressed sequence AA986860	53	0.94
chr18_74733826_74734119	0.25	Myo5b	myosin VB	207	0.94
chr6_60827248_60827682	0.25	Snca	synuclein, alpha	91	0.97
chr2_25459014_25459284	0.25	Paxx	non-homologous end joining factor	1051	0.23
chr11_104234777_104235157	0.25	Mapt	microtubule-associated protein tau	3383	0.19
chr5_64159427_64160996	0.25	Tbc1d1	TBC1 domain family, member 1	0	0.97
chr17_78290191_78290620	0.24	Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	10222	0.18
chr4_119027493_119027644	0.24	Gm12862	predicted gene 12862	27083	0.08
chr18_82489298_82489862	0.24	Mbp	myelin basic protein	14210	0.17
chr4_125488664_125489133	0.24	Grik3	glutamate receptor, ionotropic, kainate 3	1802	0.36
chr17_49436615_49437040	0.24	Mocs1	molybdenum cofactor synthesis 1	3631	0.26
chr18_83192582_83193531	0.24	1700095A13Rik	RIKEN cDNA 1700095A13 gene	85166	0.08
chr15_80190031_80190182	0.24	Mgat3	mannoside acetylglucosaminyltransferase 3	16385	0.11
chr7_24370279_24371432	0.24	Kcnn4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	517	0.59
chr1_167375050_167375216	0.24	Aldh9a1	aldehyde dehydrogenase 9, subfamily A1	10967	0.13
chr12_4873247_4874779	0.24	Mfsd2b	major facilitator superfamily domain containing 2B	332	0.82
chr3_96576165_96577539	0.24	Gm16253	predicted gene 16253	132	0.89
chr2_158308324_158308475	0.24	Lbp	lipopolysaccharide binding protein	1787	0.24
chr6_113282134_113283787	0.24	Cpne9	copine family member IX	595	0.55
chr15_102981032_102982455	0.24	Hoxc9	homeobox C9	4711	0.09
chr3_87913699_87914234	0.23	Hdgf	heparin binding growth factor	5	0.95
chr12_102355566_102356003	0.23	Rin3	Ras and Rab interactor 3	1004	0.59
chr14_34623313_34624132	0.23	Opn4	opsin 4 (melanopsin)	23580	0.11
chr9_120481695_120481846	0.23	Eif1b	eukaryotic translation initiation factor 1B	10462	0.14
chr14_56100230_56100381	0.23	Ctsg	cathepsin G	1470	0.21
chr19_4058692_4059651	0.23	Gstp3	glutathione S-transferase pi 3	124	0.88
chr16_18418352_18418503	0.23	Gm15764	predicted gene 15764	1542	0.24
chr4_140244024_140245271	0.23	Igsf21	immunoglobulin superfamily, member 21	2137	0.36
chr3_89138382_89138543	0.23	Pklr	pyruvate kinase liver and red blood cell	1839	0.14
chr4_46391513_46391664	0.23	Trmo	tRNA methyltransferase O	2151	0.22
chr2_181767278_181768191	0.23	Myt1	myelin transcription factor 1	222	0.91
chr12_13180179_13180570	0.23	Gm24208	predicted gene, 24208	16611	0.16
chr2_20736484_20738247	0.23	Etl4	enhancer trap locus 4	51	0.98
chr1_136445067_136445535	0.23	Ddx59	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	12899	0.14
chr10_12963484_12964773	0.23	Stx11	syntaxin 11	130	0.96
chr11_117946846_117947224	0.23	Socs3	suppressor of cytokine signaling 3	22151	0.11
chr3_57426561_57426712	0.22	Tm4sf4	transmembrane 4 superfamily member 4	1322	0.5
chr16_30387562_30389582	0.22	Atp13a3	ATPase type 13A3	42	0.98
chrX_137118132_137120673	0.22	Esx1	extraembryonic, spermatogenesis, homeobox 1	769	0.36
chr11_97511052_97512791	0.22	Gm11611	predicted gene 11611	9974	0.12
chr1_132365874_132366736	0.22	Tmcc2	transmembrane and coiled-coil domains 2	767	0.54
chr1_194676054_194676333	0.22	Gm38036	predicted gene, 38036	809	0.58
chr1_42707054_42709031	0.22	Pantr2	POU domain, class 3, transcription factor 3 adjacent noncoding transcript 2	10	0.97
chr18_23807443_23808685	0.22	Mapre2	microtubule-associated protein, RP/EB family, member 2	3961	0.2
chr10_42533045_42533196	0.22	Snx3	sorting nexin 3	30830	0.14
chr5_140614430_140614581	0.22	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	2820	0.18
chr16_97658836_97658987	0.22	Tmprss2	transmembrane protease, serine 2	47716	0.14
chr10_44011393_44011544	0.22	Crybg1	crystallin beta-gamma domain containing 1	7099	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0097168	mesenchymal stem cell proliferation(GO:0097168)
0.2	0.6	GO:0072050	S-shaped body morphogenesis(GO:0072050)
0.2	0.6	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.1	0.3	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.1	0.5	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1	0.4	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.4	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1	0.3	GO:0097503	sialylation(GO:0097503)
0.1	0.3	GO:1902075	cellular response to salt(GO:1902075)
0.1	0.3	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.1	0.6	GO:0002457	T cell antigen processing and presentation(GO:0002457)
0.1	0.4	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.1	0.3	GO:0033088	negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1	0.3	GO:0045963	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.1	0.2	GO:0032439	endosome localization(GO:0032439)
0.1	0.2	GO:1900211	mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212)
0.1	0.4	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.1	0.2	GO:0042167	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	0.5	GO:0043173	nucleotide salvage(GO:0043173)
0.1	0.4	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1	0.3	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.1	0.4	GO:0016198	axon choice point recognition(GO:0016198)
0.1	0.4	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.1	0.5	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.1	0.2	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1	0.3	GO:0043320	natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.1	0.2	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.1	0.2	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.2	GO:1900109	regulation of histone H3-K9 dimethylation(GO:1900109)
0.1	0.2	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1	0.2	GO:0006553	lysine metabolic process(GO:0006553)
0.1	0.2	GO:0043622	cortical microtubule organization(GO:0043622)
0.1	0.2	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1	0.2	GO:0070268	cornification(GO:0070268)
0.1	0.2	GO:1904177	regulation of adipose tissue development(GO:1904177)
0.1	0.2	GO:0070649	formin-nucleated actin cable assembly(GO:0070649)
0.0	0.2	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.8	GO:0046685	response to arsenic-containing substance(GO:0046685)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.3	GO:0002576	platelet degranulation(GO:0002576)
0.0	0.3	GO:2001185	regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.0	0.2	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.2	GO:0010288	response to lead ion(GO:0010288)
0.0	0.3	GO:0000820	regulation of glutamine family amino acid metabolic process(GO:0000820)
0.0	0.1	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.0	GO:1903116	positive regulation of actin filament-based movement(GO:1903116)
0.0	0.1	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.1	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.2	GO:0031639	plasminogen activation(GO:0031639)
0.0	0.1	GO:0001807	regulation of type IV hypersensitivity(GO:0001807)
0.0	0.4	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0	0.2	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.3	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0097477	lateral motor column neuron migration(GO:0097477)
0.0	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.1	GO:0097195	pilomotor reflex(GO:0097195)
0.0	0.1	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.1	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.2	GO:0033132	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.4	GO:0048484	enteric nervous system development(GO:0048484)
0.0	0.2	GO:0031133	regulation of axon diameter(GO:0031133)
0.0	0.1	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.0	0.1	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.2	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.0	GO:0021648	vestibulocochlear nerve morphogenesis(GO:0021648)
0.0	0.1	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.1	GO:0015793	glycerol transport(GO:0015793)
0.0	0.2	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0	0.0	GO:0021553	olfactory nerve development(GO:0021553)
0.0	1.0	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0	0.1	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0	0.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0035799	ureter maturation(GO:0035799)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0045656	negative regulation of monocyte differentiation(GO:0045656)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:1904970	brush border assembly(GO:1904970)
0.0	0.1	GO:0097466	glycoprotein ERAD pathway(GO:0097466) response to glycoprotein(GO:1904587)
0.0	0.2	GO:0002591	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.0	0.1	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.2	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.2	GO:0046040	IMP metabolic process(GO:0046040)
0.0	0.2	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.2	GO:0009992	cellular water homeostasis(GO:0009992)
0.0	0.1	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.2	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.2	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.3	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.1	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.1	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.4	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.4	GO:0033014	porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.0	0.3	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.1	GO:0035984	response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.0	0.1	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.0	0.0	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.2	GO:0060352	cell adhesion molecule production(GO:0060352)
0.0	0.0	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.0	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.0	0.0	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0	0.1	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.2	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.0	GO:0010513	phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) regulation of phosphatidylinositol biosynthetic process(GO:0010511) positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0	0.1	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.2	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.1	GO:0046959	habituation(GO:0046959)
0.0	0.1	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.0	0.2	GO:0030575	nuclear body organization(GO:0030575)
0.0	0.0	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.2	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0	0.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.2	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
0.0	0.1	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0035627	ceramide transport(GO:0035627)
0.0	0.0	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0007614	short-term memory(GO:0007614)
0.0	0.5	GO:0007019	microtubule depolymerization(GO:0007019)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0036233	glycine import(GO:0036233)
0.0	0.1	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.0	0.1	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.1	GO:0002536	respiratory burst involved in inflammatory response(GO:0002536)
0.0	0.2	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0045054	constitutive secretory pathway(GO:0045054)
0.0	0.1	GO:0022615	protein to membrane docking(GO:0022615)
0.0	0.0	GO:0072092	ureteric bud invasion(GO:0072092)
0.0	0.2	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0032229	negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0	0.1	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.0	0.0	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0	0.0	GO:0070384	Harderian gland development(GO:0070384)
0.0	0.0	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0006742	NADP catabolic process(GO:0006742)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.1	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0043096	purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.2	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.1	GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002923)
0.0	0.1	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0060282	positive regulation of oocyte development(GO:0060282)
0.0	0.1	GO:0051938	L-glutamate import(GO:0051938)
0.0	0.1	GO:0021979	hypothalamus cell differentiation(GO:0021979)
0.0	0.2	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.0	0.1	GO:0070932	histone H3 deacetylation(GO:0070932)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:0021523	somatic motor neuron differentiation(GO:0021523)
0.0	0.1	GO:0000022	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0	0.0	GO:0090240	positive regulation of histone H4 acetylation(GO:0090240)
0.0	0.0	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.0	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0	0.1	GO:1904251	regulation of bile acid metabolic process(GO:1904251)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.1	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.0	0.1	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.0	0.0	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.0	GO:1904261	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.1	GO:0010838	positive regulation of keratinocyte proliferation(GO:0010838)
0.0	0.1	GO:0036120	cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0	0.1	GO:0032460	negative regulation of protein oligomerization(GO:0032460)
0.0	0.0	GO:0021563	glossopharyngeal nerve development(GO:0021563)
0.0	0.1	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0	0.1	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.0	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.1	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.0	0.0	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.1	GO:0035630	bone mineralization involved in bone maturation(GO:0035630)
0.0	0.1	GO:0021683	cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.0	GO:0033085	negative regulation of T cell differentiation in thymus(GO:0033085)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.2	GO:1903859	regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.0	0.0	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0010626	negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.0	GO:1903715	regulation of aerobic respiration(GO:1903715)
0.0	0.0	GO:0071873	response to norepinephrine(GO:0071873)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	0.2	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.1	0.3	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	0.4	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.4	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.4	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.4	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.5	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.3	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.3	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.5	GO:0030904	retromer complex(GO:0030904)
0.0	0.2	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	2.3	GO:0072562	blood microparticle(GO:0072562)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.0	GO:0097422	tubular endosome(GO:0097422)
0.0	0.1	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	0.4	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.0	GO:0046691	intracellular canaliculus(GO:0046691)
0.0	0.1	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.1	GO:0098553	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.3	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.6	GO:0031228	intrinsic component of Golgi membrane(GO:0031228)
0.0	0.1	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.0	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0001650	fibrillar center(GO:0001650)
0.0	0.0	GO:0097452	GAIT complex(GO:0097452)
0.0	0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.0	GO:0000836	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.1	GO:0000798	nuclear cohesin complex(GO:0000798)
0.0	0.0	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.1	0.4	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.1	0.4	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.5	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.1	0.4	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.1	0.4	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.1	0.3	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1	0.6	GO:0046790	virion binding(GO:0046790)
0.1	0.4	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	0.4	GO:0005499	vitamin D binding(GO:0005499)
0.1	0.2	GO:0097016	L27 domain binding(GO:0097016)
0.1	0.3	GO:0030911	TPR domain binding(GO:0030911)
0.1	0.2	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1	0.2	GO:0015315	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	0.2	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.1	0.2	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.1	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	0.8	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.4	GO:0103116	alpha-D-galactofuranose transporter activity(GO:0103116)
0.0	0.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	0.3	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.1	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.1	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.4	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.4	GO:0048156	tau protein binding(GO:0048156)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.3	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.4	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.3	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.1	GO:0019767	IgE receptor activity(GO:0019767)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.3	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.4	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.2	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.1	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.0	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.0	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
0.0	0.1	GO:0032557	pyrimidine ribonucleotide binding(GO:0032557)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.6	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.0	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.4	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.3	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.0	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.5	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.1	GO:0034784	pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.0	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.0	GO:0005350	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.0	GO:0015141	succinate transmembrane transporter activity(GO:0015141)
0.0	0.6	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.4	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.1	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.0	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.1	GO:0010181	FMN binding(GO:0010181)
0.0	0.0	GO:0052717	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0015168	glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.4	PID ALK2 PATHWAY	ALK2 signaling events
0.9	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.6	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	PID REELIN PATHWAY	Reelin signaling pathway
0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.3	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.7	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.9	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.0	0.8	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.4	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.4	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.1	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.5	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.3	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.3	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.0	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.0	0.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.5	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	0.4	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	0.1	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)