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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nfatc4

Z-value: 0.19

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Transcription factors associated with Nfatc4

Gene Symbol	Gene ID	Gene Info
Nfatc4 Ensembl NCBI MGI UniProt	ENSMUSG00000023411.5	Nfatc4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Nfatc4	chr14_55828255_55828946	869	0.391501	0.32	1.3e-02	Click!
Nfatc4	chr14_55829268_55829478	96	0.931307	0.30	1.9e-02	Click!
Nfatc4	chr14_55824784_55826081	369	0.734082	0.26	4.1e-02	Click!
Nfatc4	chr14_55822882_55823033	187	0.880957	0.24	6.4e-02	Click!
Nfatc4	chr14_55831685_55831836	1491	0.222718	0.23	8.0e-02	Click!

Activity of the Nfatc4 motif across conditions

Conditions sorted by the z-value of the Nfatc4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_74689028_74690409	0.21	Hoxd10	homeobox D10	2206	0.09
chr4_156057650_156058246	0.14	Ttll10	tubulin tyrosine ligase-like family, member 10	1396	0.16
chr8_33926179_33926910	0.11	Rbpms	RNA binding protein gene with multiple splicing	2732	0.25
chr9_75773918_75774501	0.10	Bmp5	bone morphogenetic protein 5	1155	0.53
chr7_134228173_134228324	0.10	A130023I24Rik	RIKEN cDNA A130023I24 gene	1072	0.52
chr6_52174920_52176658	0.10	Hoxaas3	Hoxa cluster antisense RNA 3	554	0.41
chr5_90519467_90519771	0.09	Afm	afamin	670	0.59
chr7_142661369_142661520	0.09	Igf2	insulin-like growth factor 2	139	0.91
chr11_96340356_96341209	0.08	Hoxb3	homeobox B3	163	0.85
chr1_78816815_78817194	0.08	Kcne4	potassium voltage-gated channel, Isk-related subfamily, gene 4	77	0.97
chr6_51401722_51401977	0.08	0610033M10Rik	RIKEN cDNA 0610033M10 gene	184	0.94
chr10_105794148_105794388	0.08	n-R5s80	nuclear encoded rRNA 5S 80	9929	0.18
chr6_48707880_48708301	0.07	Gimap6	GTPase, IMAP family member 6	106	0.91
chr8_87570471_87571218	0.07	4933402J07Rik	RIKEN cDNA 4933402J07 gene	6991	0.21
chr9_45042261_45043690	0.07	Mpzl2	myelin protein zero-like 2	279	0.8
chr1_184731287_184732512	0.07	Hlx	H2.0-like homeobox	301	0.86
chr3_137343040_137343246	0.07	Emcn	endomucin	1969	0.42
chr2_169996778_169996974	0.07	AY702102	cDNA sequence AY702102	33689	0.22
chr4_49545411_49545633	0.07	Aldob	aldolase B, fructose-bisphosphate	4024	0.16
chr7_100924536_100925334	0.07	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	7172	0.15
chr19_5558301_5558859	0.06	Ovol1	ovo like zinc finger 1	823	0.33
chr7_75457069_75457220	0.06	Akap13	A kinase (PRKA) anchor protein 13	1276	0.42
chr9_123214842_123215032	0.06	Cdcp1	CUB domain containing protein 1	1062	0.46
chr13_98626689_98627173	0.06	Gm48050	predicted gene, 48050	9269	0.13
chr2_35691764_35692937	0.06	Dab2ip	disabled 2 interacting protein	17	0.98
chr9_42884724_42884990	0.06	Gm27509	predicted gene, 27509	22728	0.19
chr16_23102639_23103369	0.06	Eif4a2	eukaryotic translation initiation factor 4A2	4440	0.07
chr10_10546265_10546583	0.06	Rab32	RAB32, member RAS oncogene family	11757	0.2
chr12_71342419_71342699	0.06	Gm33016	predicted gene, 33016	4931	0.16
chr5_134342577_134343060	0.06	Mir3965	microRNA 3965	16364	0.12
chr8_36829881_36830312	0.06	Dlc1	deleted in liver cancer 1	97042	0.08
chr18_69665931_69667348	0.06	Tcf4	transcription factor 4	9972	0.29
chr1_45924247_45924747	0.06	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	765	0.56
chr13_21720851_21721002	0.05	Gm44357	predicted gene, 44357	507	0.36
chr8_107198114_107198786	0.05	Cyb5b	cytochrome b5 type B	32535	0.13
chr13_89540278_89541317	0.05	Hapln1	hyaluronan and proteoglycan link protein 1	1001	0.64
chr1_78817332_78818790	0.05	Kcne4	potassium voltage-gated channel, Isk-related subfamily, gene 4	1134	0.48
chr15_72971199_72971927	0.05	Gm3150	predicted gene 3150	58206	0.13
chr5_119662786_119663760	0.05	Tbx3	T-box 3	7396	0.14
chr13_21820445_21820658	0.05	Hist1h4m	histone cluster 1, H4m	8805	0.05
chr2_84423814_84425562	0.05	Calcrl	calcitonin receptor-like	578	0.75
chr8_92761797_92762731	0.05	Gapdh-ps16	glyceraldehyde-3-phosphate dehydrogenase, pseudogene 16	45289	0.12
chr4_135727528_135728972	0.05	Il22ra1	interleukin 22 receptor, alpha 1	78	0.96
chr6_117919030_117919254	0.05	Gm43863	predicted gene, 43863	1420	0.24
chr10_22822761_22823454	0.05	Tcf21	transcription factor 21	2933	0.22
chr5_66149768_66149919	0.05	Rbm47	RNA binding motif protein 47	1113	0.3
chr17_38303471_38303622	0.05	Olfr137	olfactory receptor 137	1914	0.25
chr6_17309182_17310034	0.05	Cav1	caveolin 1, caveolae protein	1885	0.33
chr8_84654998_84655201	0.05	Ier2	immediate early response 2	7755	0.1
chr12_104584053_104584862	0.05	Gm49732	predicted gene, 49732	64489	0.1
chr4_33245981_33246490	0.05	Pnrc1	proline-rich nuclear receptor coactivator 1	1340	0.4
chr13_104122133_104122507	0.05	Sgtb	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	12491	0.16
chr6_30544847_30545729	0.05	Cpa2	carboxypeptidase A2, pancreatic	803	0.52
chr9_117249167_117249456	0.05	Rbms3	RNA binding motif, single stranded interacting protein	2286	0.33
chr13_38959403_38959696	0.05	Slc35b3	solute carrier family 35, member B3	931	0.42
chr6_138143538_138143877	0.05	Mgst1	microsomal glutathione S-transferase 1	853	0.73
chr6_5255342_5256653	0.05	Pon3	paraoxonase 3	217	0.93
chr11_98904753_98905026	0.05	Cdc6	cell division cycle 6	2912	0.15
chr2_34774288_34775191	0.05	Hspa5	heat shock protein 5	108	0.95
chr16_50752363_50752789	0.04	Dubr	Dppa2 upstream binding RNA	19803	0.17
chr4_115001106_115001269	0.04	Stil	Scl/Tal1 interrupting locus	1005	0.49
chr3_53055538_53055689	0.04	Gm42901	predicted gene 42901	13858	0.11
chr2_137109115_137109266	0.04	Jag1	jagged 1	7454	0.29
chr17_5753255_5753544	0.04	3300005D01Rik	RIKEN cDNA 3300005D01 gene	45258	0.13
chr13_43123788_43124308	0.04	Phactr1	phosphatase and actin regulator 1	1176	0.42
chr19_55260209_55260360	0.04	Acsl5	acyl-CoA synthetase long-chain family member 5	6915	0.18
chrX_106483380_106483727	0.04	Fndc3c1	fibronectin type III domain containing 3C1	1344	0.43
chr15_98606352_98606619	0.04	Adcy6	adenylate cyclase 6	1148	0.29
chr16_44348732_44349059	0.04	Spice1	spindle and centriole associated protein 1	849	0.63
chr13_115054607_115055088	0.04	Gm10734	predicted gene 10734	34654	0.12
chr5_90773168_90773319	0.04	Pf4	platelet factor 4	352	0.76
chr16_31575640_31575823	0.04	Gm34256	predicted gene, 34256	17489	0.16
chr2_103283203_103283868	0.04	Ehf	ets homologous factor	225	0.93
chr2_156324321_156324820	0.04	Gm22759	predicted gene, 22759	2018	0.15
chr9_89497806_89497957	0.04	Gm47403	predicted gene, 47403	62503	0.11
chr10_44002146_44002297	0.04	Gm10812	predicted gene 10812	1933	0.28
chr13_40136054_40136205	0.04	Ofcc1	orofacial cleft 1 candidate 1	151882	0.04
chr11_40734727_40734972	0.04	Nudcd2	NudC domain containing 2	644	0.6
chr7_127769289_127770591	0.04	Orai3	ORAI calcium release-activated calcium modulator 3	125	0.9
chr1_39574806_39574957	0.04	Gm23722	predicted gene, 23722	1006	0.38
chr19_5257020_5257171	0.04	Gm50189	predicted gene, 50189	1655	0.19
chr11_98412611_98413343	0.04	Erbb2	erb-b2 receptor tyrosine kinase 2	484	0.6
chr5_140890731_140891173	0.04	Card11	caspase recruitment domain family, member 11	8747	0.24
chr14_22049015_22049482	0.04	Gm7480	predicted gene 7480	13145	0.16
chr2_35060883_35061388	0.04	Hc	hemolytic complement	303	0.88
chr11_117611027_117611290	0.04	2900041M22Rik	RIKEN cDNA 2900041M22 gene	89	0.97
chr1_39636608_39636940	0.04	D930019O06Rik	RIKEN cDNA D930019O06	13402	0.13
chr5_59968294_59968445	0.04	Gm43041	predicted gene 43041	12229	0.17
chr5_20941736_20941887	0.04	Rsbn1l	round spermatid basic protein 1-like	3693	0.2
chr15_80674232_80674436	0.04	Fam83f	family with sequence similarity 83, member F	2487	0.2
chr7_96533226_96533480	0.04	Tenm4	teneurin transmembrane protein 4	10955	0.26
chr3_100479788_100480010	0.04	Tent5c	terminal nucleotidyltransferase 5C	9295	0.14
chr1_121096624_121097922	0.04	Celrr	cerebellum expressed regulatory RNA	9744	0.27
chr8_128688078_128688272	0.04	Itgb1	integrin beta 1 (fibronectin receptor beta)	2305	0.29
chr5_147299313_147300749	0.04	Cdx2	caudal type homeobox 2	7239	0.1
chr8_45627436_45629381	0.04	Sorbs2	sorbin and SH3 domain containing 2	207	0.94
chr8_109360134_109360931	0.04	Gm1943	predicted gene 1943	19668	0.22
chr6_138140044_138141370	0.04	Mgst1	microsomal glutathione S-transferase 1	108	0.98
chr18_61045132_61047010	0.04	Pdgfrb	platelet derived growth factor receptor, beta polypeptide	871	0.5
chr5_26075770_26075952	0.04	Gm6089	predicted gene 6089	5324	0.12
chr2_139634376_139634527	0.04	Gm14066	predicted gene 14066	43263	0.14
chr10_93454496_93455097	0.04	Lta4h	leukotriene A4 hydrolase	1345	0.38
chr10_87524981_87525132	0.04	Pah	phenylalanine hydroxylase	3029	0.26
chr6_83032569_83034015	0.04	Dok1	docking protein 1	176	0.8
chr14_65951762_65951913	0.04	Scara3	scavenger receptor class A, member 3	2098	0.27
chr2_148023997_148024148	0.04	9030622O22Rik	RIKEN cDNA 9030622O22 gene	14198	0.17
chr10_87007185_87007640	0.04	Stab2	stabilin 2	600	0.7
chr13_21452056_21452233	0.04	Zscan26	zinc finger and SCAN domain containing 26	1516	0.16
chr3_59129690_59130148	0.04	P2ry14	purinergic receptor P2Y, G-protein coupled, 14	703	0.66
chr13_23582405_23582731	0.03	H4c4	H4 clustered histone 4	970	0.2
chr12_78205797_78206679	0.03	Gm6657	predicted gene 6657	5272	0.17
chr3_152212912_152213690	0.03	Fubp1	far upstream element (FUSE) binding protein 1	2780	0.17
chr7_143685249_143686318	0.03	Tnfrsf23	tumor necrosis factor receptor superfamily, member 23	88	0.95
chr8_11779325_11780029	0.03	Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	2850	0.19
chr17_43395854_43396005	0.03	Adgrf5	adhesion G protein-coupled receptor F5	6441	0.25
chr5_32611887_32612080	0.03	Gm10461	predicted gene 10461	178	0.83
chr1_189730413_189731175	0.03	Ptpn14	protein tyrosine phosphatase, non-receptor type 14	2519	0.29
chr10_93347628_93348351	0.03	Gm17745	predicted gene, 17745	12596	0.16
chr6_117130561_117131249	0.03	Gm43930	predicted gene, 43930	13420	0.19
chr8_53637994_53639312	0.03	Neil3	nei like 3 (E. coli)	25	0.99
chrX_12286250_12287038	0.03	Gm14635	predicted gene 14635	58578	0.14
chr6_125426842_125427196	0.03	Cd9	CD9 antigen	36005	0.1
chr1_134992164_134992455	0.03	Ube2t	ubiquitin-conjugating enzyme E2T	20353	0.15
chr11_49246331_49246550	0.03	Mgat1	mannoside acetylglucosaminyltransferase 1	1037	0.4
chr12_73287843_73287994	0.03	Slc38a6	solute carrier family 38, member 6	858	0.48
chr12_53408081_53408232	0.03	1700030L22Rik	RIKEN cDNA 1700030L22 gene	98310	0.09
chr2_74722101_74723871	0.03	Hoxd4	homeobox D4	1008	0.22
chrY_1246020_1246180	0.03	Uty	ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome	341	0.86
chr2_177839442_177839866	0.03	Gm14325	predicted gene 14325	664	0.67
chr4_84672964_84673574	0.03	Bnc2	basonuclin 2	1727	0.42
chr18_63689730_63689974	0.03	Txnl1	thioredoxin-like 1	2470	0.26
chr10_21995510_21995970	0.03	Sgk1	serum/glucocorticoid regulated kinase 1	830	0.57
chr6_114875505_114875725	0.03	Vgll4	vestigial like family member 4	508	0.81
chr6_119416453_119417745	0.03	Adipor2	adiponectin receptor 2	376	0.88
chrX_53058333_53059722	0.03	C430049B03Rik	RIKEN cDNA C430049B03 gene	1837	0.16
chr2_84713270_84713499	0.03	Zdhhc5	zinc finger, DHHC domain containing 5	1302	0.22
chr4_46401911_46402304	0.03	Hemgn	hemogen	2129	0.22
chr12_68675940_68676091	0.03	n-R5s61	nuclear encoded rRNA 5S 61	75045	0.09
chr2_138264683_138264834	0.03	Btbd3	BTB (POZ) domain containing 3	8088	0.33
chr5_130022581_130023074	0.03	Asl	argininosuccinate lyase	1473	0.28
chr6_120195255_120195624	0.03	Ninj2	ninjurin 2	1616	0.41
chr17_80825543_80826587	0.03	C230072F16Rik	RIKEN cDNA C230072F16 gene	70728	0.1
chr8_68279205_68280180	0.03	Sh2d4a	SH2 domain containing 4A	2615	0.27
chr2_180512043_180512194	0.03	Ntsr1	neurotensin receptor 1	11891	0.16
chr2_29546441_29547087	0.03	Med27	mediator complex subunit 27	41893	0.12
chr10_60563030_60563532	0.03	Cdh23	cadherin 23 (otocadherin)	89752	0.08
chr14_78012288_78012541	0.03	Gm48954	predicted gene, 48954	7314	0.21
chr1_150898005_150898378	0.03	Hmcn1	hemicentin 1	94860	0.07
chr8_123102029_123102227	0.03	Rpl13	ribosomal protein L13	222	0.79
chr16_72719540_72719691	0.03	Robo1	roundabout guidance receptor 1	56411	0.18
chr4_123233207_123234595	0.03	Heyl	hairy/enhancer-of-split related with YRPW motif-like	48	0.96
chr10_99267189_99269284	0.03	Gm48089	predicted gene, 48089	340	0.78
chr4_3937146_3938329	0.03	Plag1	pleiomorphic adenoma gene 1	645	0.54
chr2_128377708_128377954	0.03	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	25134	0.18
chr7_27596549_27597871	0.03	Akt2	thymoma viral proto-oncogene 2	380	0.77
chr17_71236074_71236240	0.03	Lpin2	lipin 2	2505	0.25
chr6_75117264_75117415	0.03	Gm8992	predicted gene 8992	70829	0.12
chr6_108235668_108236315	0.03	Itpr1	inositol 1,4,5-trisphosphate receptor 1	16967	0.23
chr9_65574695_65575665	0.03	Plekho2	pleckstrin homology domain containing, family O member 2	1920	0.26
chr15_39078038_39078699	0.03	Cthrc1	collagen triple helix repeat containing 1	1287	0.33
chr11_102609159_102609359	0.03	Fzd2	frizzled class receptor 2	4863	0.11
chr12_69757617_69759559	0.03	Mir681	microRNA 681	5356	0.14
chr17_19455750_19455901	0.03	Vmn2r-ps121	vomeronasal 2, receptor, pseudogene 121	2500	0.3
chr4_100863972_100864540	0.03	Cachd1	cache domain containing 1	87581	0.09
chr10_98624940_98625347	0.03	Gm5427	predicted gene 5427	74567	0.11
chr3_90220236_90221599	0.03	Rab13	RAB13, member RAS oncogene family	130	0.91
chr4_134766990_134768275	0.03	Ldlrap1	low density lipoprotein receptor adaptor protein 1	392	0.86
chr2_79256898_79257323	0.03	Itga4	integrin alpha 4	1163	0.57
chr1_168754197_168754399	0.03	1700063I16Rik	RIKEN cDNA 1700063I16 gene	78416	0.12
chr11_76997745_76998893	0.03	Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	284	0.87
chr15_77142814_77142965	0.03	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	10109	0.14
chr13_78629090_78629413	0.03	Gm48402	predicted gene, 48402	8766	0.3
chr12_100998948_100999342	0.03	Gm36756	predicted gene, 36756	6173	0.13
chr3_109025772_109026235	0.03	Fam102b	family with sequence similarity 102, member B	1270	0.37
chr7_29799575_29799936	0.03	Gm6579	predicted gene 6579	41	0.95
chr13_63560468_63561467	0.03	Ptch1	patched 1	2848	0.2
chrX_169685204_169686251	0.03	Mid1	midline 1	528	0.82
chr13_88872554_88872705	0.03	Edil3	EGF-like repeats and discoidin I-like domains 3	50987	0.19
chr7_116267794_116268386	0.03	Plekha7	pleckstrin homology domain containing, family A member 7	3662	0.2
chr16_95618168_95618511	0.03	Erg	ETS transcription factor	31746	0.2
chr4_126490666_126491063	0.03	Gm12928	predicted gene 12928	13565	0.1
chr7_141442950_141444299	0.03	Pidd1	p53 induced death domain protein 1	268	0.74
chr7_73606673_73607479	0.03	Gm44734	predicted gene 44734	1872	0.21
chr11_100702726_100703447	0.03	Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	261	0.82
chr6_52273154_52274564	0.03	Hottip	Hoxa distal transcript antisense RNA	11075	0.06
chr14_109083684_109083835	0.03	Slitrk1	SLIT and NTRK-like family, member 1	169601	0.04
chr14_27337217_27337907	0.03	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	1496	0.45
chr14_36918744_36919600	0.03	Ccser2	coiled-coil serine rich 2	161	0.97
chr15_56694253_56695303	0.03	Has2	hyaluronan synthase 2	239	0.85
chrX_9467520_9467766	0.03	Cybb	cytochrome b-245, beta polypeptide	1626	0.4
chr1_164062190_164062341	0.03	Sell	selectin, lymphocyte	76	0.96
chr6_56704794_56705009	0.03	Lsm5	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated	191	0.94
chr7_84688773_84688924	0.03	2610206C17Rik	RIKEN cDNA 2610206C17 gene	792	0.47
chr11_102603430_102604064	0.03	Fzd2	frizzled class receptor 2	649	0.54
chr13_72625092_72626461	0.03	Gm20554	predicted gene, 20554	2788	0.27
chr4_116166621_116166961	0.03	Tspan1	tetraspanin 1	809	0.42
chr2_127729042_127730365	0.03	Mall	mal, T cell differentiation protein-like	229	0.9
chr8_45261536_45262005	0.03	F11	coagulation factor XI	261	0.91
chr8_79030497_79030682	0.03	Zfp827	zinc finger protein 827	2002	0.34
chr10_37139080_37141738	0.02	5930403N24Rik	RIKEN cDNA 5930403N24 gene	495	0.74

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.1	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	GO:0009804	coumarin metabolic process(GO:0009804)
0.1	GO:0032345	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.0	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.1	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	GO:0055100	adiponectin binding(GO:0055100)
0.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)