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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nfe2l1_Mafg

Z-value: 0.40

Motif logo

Transcription factors associated with Nfe2l1_Mafg

Gene Symbol	Gene ID	Gene Info
Nfe2l1 Ensembl NCBI MGI UniProt	ENSMUSG00000038615.11	Nfe2l1
Mafg Ensembl NCBI MGI UniProt	ENSMUSG00000051510.7	Mafg
Mafg Ensembl NCBI MGI UniProt	ENSMUSG00000053906.4	Mafg

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Mafg	chr11_120635927_120636078	2402	0.087462	-0.40	1.4e-03	Click!
Mafg	chr11_120637299_120637552	3825	0.065678	-0.19	1.5e-01	Click!
Mafg	chr11_120633726_120633919	222	0.773977	0.16	2.2e-01	Click!
Mafg	chr11_120632083_120632234	1361	0.154242	0.15	2.4e-01	Click!
Mafg	chr11_120628347_120628498	1726	0.114680	0.12	3.5e-01	Click!
Nfe2l1	chr11_96837393_96837544	7500	0.097092	-0.45	3.4e-04	Click!
Nfe2l1	chr11_96818178_96818461	4406	0.116272	-0.39	2.3e-03	Click!
Nfe2l1	chr11_96830243_96830655	481	0.660634	0.29	2.4e-02	Click!
Nfe2l1	chr11_96828944_96829908	75	0.943784	0.22	8.5e-02	Click!
Nfe2l1	chr11_96823513_96824552	19	0.954431	-0.21	1.0e-01	Click!

Activity of the Nfe2l1_Mafg motif across conditions

Conditions sorted by the z-value of the Nfe2l1_Mafg motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_75577269_75578512	0.25	Kit	KIT proto-oncogene receptor tyrosine kinase	2935	0.29
chr13_109928298_109928867	0.22	Pde4d	phosphodiesterase 4D, cAMP specific	1738	0.46
chr16_91466275_91466861	0.22	Gm49626	predicted gene, 49626	1443	0.19
chr15_78116860_78117881	0.22	A730060N03Rik	RIKEN cDNA A730060N03 gene	2336	0.22
chr11_101011506_101011900	0.18	Atp6v0a1	ATPase, H+ transporting, lysosomal V0 subunit A1	118	0.94
chr9_95561747_95561983	0.18	Paqr9	progestin and adipoQ receptor family member IX	2208	0.22
chr9_74977325_74977617	0.18	Fam214a	family with sequence similarity 214, member A	1360	0.45
chrX_165326400_165326667	0.17	Glra2	glycine receptor, alpha 2 subunit	860	0.76
chr15_13367879_13368144	0.17	Gm8238	predicted gene 8238	50845	0.16
chr4_13754294_13755025	0.17	Runx1t1	RUNX1 translocation partner 1	3362	0.37
chr1_136132801_136134260	0.17	Kif21b	kinesin family member 21B	2076	0.19
chr9_10903129_10903698	0.16	Gm32710	predicted gene, 32710	932	0.44
chr1_164454554_164455430	0.16	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	1215	0.39
chr11_61453075_61454398	0.15	Rnf112	ring finger protein 112	183	0.92
chr11_62005417_62006894	0.15	Specc1	sperm antigen with calponin homology and coiled-coil domains 1	805	0.61
chr10_101682665_101683088	0.15	Mgat4c	MGAT4 family, member C	1130	0.6
chr15_85675143_85675686	0.15	Lncppara	long noncoding RNA near Ppara	21798	0.12
chr6_28827182_28827949	0.14	Lrrc4	leucine rich repeat containing 4	2780	0.27
chr9_95562029_95562400	0.14	Paqr9	progestin and adipoQ receptor family member IX	2557	0.2
chr4_82589377_82589629	0.14	Gm11267	predicted gene 11267	2184	0.36
chr10_90577565_90578158	0.14	Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	869	0.72
chr8_86615787_86615938	0.13	Lonp2	lon peptidase 2, peroxisomal	8181	0.17
chr1_146500124_146500296	0.13	Brinp3	bone morphogenetic protein/retinoic acid inducible neural specific 3	2472	0.28
chr2_97470022_97470462	0.13	Lrrc4c	leucine rich repeat containing 4C	2153	0.46
chr9_21196536_21198489	0.13	Pde4a	phosphodiesterase 4A, cAMP specific	807	0.45
chr10_77112255_77113959	0.13	Col18a1	collagen, type XVIII, alpha 1	598	0.73
chr12_71048661_71048812	0.13	Arid4a	AT rich interactive domain 4A (RBP1-like)	395	0.84
chr9_112232861_112233588	0.13	Arpp21	cyclic AMP-regulated phosphoprotein, 21	402	0.75
chr5_43236032_43236320	0.13	Gm7854	predicted gene 7854	821	0.45
chr18_31445651_31446131	0.13	Syt4	synaptotagmin IV	1515	0.34
chr3_80798105_80798468	0.13	Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	4293	0.29
chr6_87424489_87424700	0.12	Bmp10	bone morphogenetic protein 10	4400	0.17
chr11_28582033_28582291	0.12	Ccdc85a	coiled-coil domain containing 85A	1833	0.45
chr8_54957960_54958420	0.12	Gm45263	predicted gene 45263	1629	0.32
chr1_173941256_173941415	0.12	Ifi203	interferon activated gene 203	1119	0.39
chr8_9767652_9767828	0.12	Fam155a	family with sequence similarity 155, member A	2364	0.22
chr13_69736057_69736269	0.12	Ube2ql1	ubiquitin-conjugating enzyme E2Q family-like 1	3726	0.16
chr5_84412572_84412901	0.12	Epha5	Eph receptor A5	4070	0.29
chr6_55338294_55340060	0.12	Aqp1	aquaporin 1	2745	0.22
chr16_97168993_97169144	0.12	Dscam	DS cell adhesion molecule	1684	0.52
chr3_136673390_136673717	0.12	Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	2783	0.31
chr7_103825389_103825783	0.12	Hbb-bs	hemoglobin, beta adult s chain	2139	0.11
chr19_5842574_5845856	0.12	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	1044	0.25
chr4_36948006_36948454	0.12	Lingo2	leucine rich repeat and Ig domain containing 2	2237	0.35
chr4_70532291_70532442	0.11	Megf9	multiple EGF-like-domains 9	2562	0.43
chr1_124042617_124042950	0.11	Dpp10	dipeptidylpeptidase 10	2380	0.44
chr11_46440995_46441189	0.11	Med7	mediator complex subunit 7	1440	0.31
chr5_135806693_135807939	0.11	Srrm3	serine/arginine repetitive matrix 3	419	0.73
chr9_19994680_19994831	0.11	Olfr864-ps1	olfactory receptor 864, pseudogene 1	1678	0.24
chr14_55054880_55055132	0.11	Gm20687	predicted gene 20687	49	0.92
chr1_81076133_81076284	0.11	Nyap2	neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2	742	0.79
chr6_142962344_142962495	0.11	St8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	1722	0.29
chr6_137253502_137253687	0.11	Ptpro	protein tyrosine phosphatase, receptor type, O	1129	0.6
chr1_173801485_173801725	0.11	Ifi203-ps	interferon activated gene 203, pseudogene	3335	0.17
chr14_60381648_60381975	0.11	Amer2	APC membrane recruitment 2	3525	0.27
chr18_69599939_69600665	0.11	Tcf4	transcription factor 4	766	0.75
chr11_104234777_104235157	0.11	Mapt	microtubule-associated protein tau	3383	0.19
chr12_108605770_108606876	0.11	Evl	Ena-vasodilator stimulated phosphoprotein	557	0.74
chr7_80200040_80200211	0.11	Sema4b	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	1589	0.23
chr18_31442020_31442171	0.11	Gm26658	predicted gene, 26658	1777	0.3
chr7_61981610_61982350	0.11	A330076H08Rik	RIKEN cDNA A330076H08 gene	323	0.52
chr8_46472677_46473081	0.11	Gm45244	predicted gene 45244	711	0.56
chr16_76318105_76318441	0.10	Nrip1	nuclear receptor interacting protein 1	5385	0.27
chr14_34675529_34675753	0.10	Wapl	WAPL cohesin release factor	1468	0.27
chr7_51630779_51630985	0.10	Gm45072	predicted gene 45072	843	0.52
chr11_31874060_31874636	0.10	Cpeb4	cytoplasmic polyadenylation element binding protein 4	1073	0.55
chr18_43390784_43391261	0.10	Dpysl3	dihydropyrimidinase-like 3	2355	0.34
chr7_131968717_131968868	0.10	Gpr26	G protein-coupled receptor 26	2332	0.32
chr2_103958009_103958847	0.10	Lmo2	LIM domain only 2	433	0.78
chr3_149069217_149069368	0.10	Gm25127	predicted gene, 25127	40360	0.16
chr10_12611642_12612156	0.10	Utrn	utrophin	2932	0.38
chr2_138277835_138280637	0.10	Btbd3	BTB (POZ) domain containing 3	743	0.81
chr14_108909489_108909909	0.10	Slitrk1	SLIT and NTRK-like family, member 1	4459	0.37
chr9_37527353_37531611	0.10	Esam	endothelial cell-specific adhesion molecule	701	0.51
chr3_89522754_89523224	0.10	Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	2825	0.22
chr9_68888905_68889137	0.10	Rora	RAR-related orphan receptor alpha	233718	0.02
chr16_92824962_92826063	0.10	Runx1	runt related transcription factor 1	266	0.94
chr7_87588060_87588319	0.10	Grm5	glutamate receptor, metabotropic 5	3791	0.35
chr13_42711375_42711526	0.10	Phactr1	phosphatase and actin regulator 1	1869	0.43
chr3_136672766_136672917	0.10	Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	2071	0.37
chr18_62176067_62177775	0.10	Adrb2	adrenergic receptor, beta 2	3038	0.24
chr2_134825693_134826026	0.10	Gm14036	predicted gene 14036	21910	0.2
chr8_46496910_46497239	0.10	Acsl1	acyl-CoA synthetase long-chain family member 1	4242	0.18
chr6_67034885_67035063	0.10	E230016M11Rik	RIKEN cDNA E230016M11 gene	1625	0.23
chr8_90869910_90870860	0.10	Gm45640	predicted gene 45640	6196	0.14
chr15_54572723_54573229	0.10	Mal2	mal, T cell differentiation protein 2	1784	0.45
chr2_94055302_94055453	0.10	Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	11092	0.18
chrX_23283125_23283785	0.10	Klhl13	kelch-like 13	1374	0.57
chr14_101841859_101842332	0.10	Lmo7	LIM domain only 7	1276	0.57
chr8_109245493_109246323	0.10	D030068K23Rik	RIKEN cDNA D030068K23 gene	3958	0.33
chr8_61515132_61515409	0.10	Palld	palladin, cytoskeletal associated protein	630	0.77
chr15_59079090_59079241	0.10	Mtss1	MTSS I-BAR domain containing 1	2824	0.32
chrX_144686917_144687223	0.09	Trpc5	transient receptor potential cation channel, subfamily C, member 5	933	0.55
chr16_42907540_42907820	0.09	Zbtb20	zinc finger and BTB domain containing 20	28	0.98
chrX_111443823_111443974	0.09	Rps6ka6	ribosomal protein S6 kinase polypeptide 6	18741	0.28
chr1_79437828_79438003	0.09	Scg2	secretogranin II	2127	0.4
chr8_121730928_121732115	0.09	Jph3	junctophilin 3	954	0.49
chr13_20474951_20475127	0.09	Gm32036	predicted gene, 32036	1549	0.33
chr16_46008622_46009173	0.09	Plcxd2	phosphatidylinositol-specific phospholipase C, X domain containing 2	1321	0.41
chr3_96181539_96182795	0.09	Sv2a	synaptic vesicle glycoprotein 2 a	1016	0.22
chr2_82055274_82055801	0.09	Zfp804a	zinc finger protein 804A	2315	0.43
chr3_152866007_152866344	0.09	Gm16232	predicted gene 16232	10042	0.2
chr10_81426043_81427197	0.09	Nfic	nuclear factor I/C	494	0.54
chr11_87762635_87763192	0.09	Tspoap1	TSPO associated protein 1	1818	0.17
chr11_90196330_90196540	0.09	Gm45883	predicted gene 45883	8260	0.16
chr5_66678971_66679451	0.09	Uchl1	ubiquitin carboxy-terminal hydrolase L1	2319	0.2
chr13_117022581_117022756	0.09	Parp8	poly (ADP-ribose) polymerase family, member 8	2605	0.3
chr19_38265533_38266016	0.09	Lgi1	leucine-rich repeat LGI family, member 1	364	0.85
chr1_3667888_3668100	0.09	Xkr4	X-linked Kx blood group related 4	3504	0.21
chr15_78404813_78404964	0.09	Tst	thiosulfate sulfurtransferase, mitochondrial	964	0.32
chr12_5372599_5372750	0.09	Klhl29	kelch-like 29	3008	0.28
chr11_115511512_115512231	0.09	Jpt1	Jupiter microtubule associated homolog 1	2245	0.14
chr1_70725543_70726581	0.09	Vwc2l	von Willebrand factor C domain-containing protein 2-like	139	0.98
chr13_59819810_59820064	0.09	Tut7	terminal uridylyl transferase 7	2651	0.15
chr2_23562980_23563209	0.09	Spopl	speckle-type BTB/POZ protein-like	8884	0.24
chr16_77236514_77236677	0.09	Mir99ahg	Mir99a and Mirlet7c-1 host gene (non-protein coding)	276	0.93
chr18_56922535_56922923	0.09	Marchf3	membrane associated ring-CH-type finger 3	2786	0.27
chr12_56253431_56254088	0.09	Gm19990	predicted gene, 19990	516	0.47
chr7_122673354_122673569	0.09	Cacng3	calcium channel, voltage-dependent, gamma subunit 3	2043	0.32
chr6_120819578_120819729	0.09	Atp6v1e1	ATPase, H+ transporting, lysosomal V1 subunit E1	1254	0.37
chr15_36275796_36275947	0.09	Rnf19a	ring finger protein 19A	7227	0.13
chr5_151188598_151188749	0.09	Stard13	StAR-related lipid transfer (START) domain containing 13	1477	0.48
chr14_64575803_64576191	0.09	Mir124a-1hg	Mir124-1 host gene (non-protein coding)	11334	0.15
chr6_24047175_24047352	0.09	Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	61308	0.12
chr4_32862939_32864770	0.09	Ankrd6	ankyrin repeat domain 6	3171	0.24
chr8_121904943_121905414	0.09	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	2516	0.15
chr2_148404766_148404943	0.09	Thbd	thrombomodulin	3334	0.2
chr10_111166520_111166791	0.09	Osbpl8	oxysterol binding protein-like 8	1853	0.27
chr3_94412462_94413013	0.09	1700040D17Rik	RIKEN cDNA 1700040D17 gene	182	0.67
chr15_78571734_78572724	0.09	Rac2	Rac family small GTPase 2	552	0.62
chr1_75277211_75278430	0.09	Resp18	regulated endocrine-specific protein 18	464	0.62
chr4_138251495_138252773	0.09	Sh2d5	SH2 domain containing 5	1670	0.22
chr19_26751454_26751605	0.09	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	407	0.88
chr19_8840785_8841292	0.09	Bscl2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	503	0.44
chr7_126823319_126824529	0.09	Fam57b	family with sequence similarity 57, member B	621	0.41
chr5_9721072_9721322	0.09	Grm3	glutamate receptor, metabotropic 3	3973	0.27
chr8_93814307_93815014	0.09	4930488L21Rik	RIKEN cDNA 4930488L21 gene	938	0.54
chrX_85870254_85870648	0.09	5430427O19Rik	RIKEN cDNA 5430427O19 gene	97	0.97
chr1_162898137_162898420	0.09	Fmo2	flavin containing monooxygenase 2	206	0.94
chr2_60960139_60960473	0.09	Rbms1	RNA binding motif, single stranded interacting protein 1	2886	0.3
chr2_24385363_24386049	0.09	Psd4	pleckstrin and Sec7 domain containing 4	353	0.84
chr5_150261018_150262108	0.09	Fry	FRY microtubule binding protein	1796	0.34
chr6_67228511_67229348	0.09	Gm44052	predicted gene, 44052	6385	0.13
chr1_172501767_172503923	0.09	Tagln2	transgelin 2	1593	0.22
chr11_15096657_15096828	0.09	Gm12009	predicted gene 12009	47584	0.2
chr3_51636519_51637197	0.08	Gm38247	predicted gene, 38247	70	0.96
chr2_6870837_6870988	0.08	Celf2	CUGBP, Elav-like family member 2	1060	0.55
chr1_38012822_38013138	0.08	Eif5b	eukaryotic translation initiation factor 5B	14851	0.14
chr1_140182842_140183316	0.08	Cfh	complement component factor h	201	0.96
chr11_20331076_20331227	0.08	Slc1a4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4	1533	0.37
chr15_37457581_37457955	0.08	Ncald	neurocalcin delta	773	0.56
chrX_167207304_167207608	0.08	Tmsb4x	thymosin, beta 4, X chromosome	1371	0.45
chr11_43834010_43835381	0.08	Adra1b	adrenergic receptor, alpha 1b	1637	0.47
chr10_33256172_33256374	0.08	D830005E20Rik	RIKEN cDNA D830005E20 gene	84	0.97
chr1_115687470_115687621	0.08	Cntnap5a	contactin associated protein-like 5A	2789	0.31
chr17_44809334_44809504	0.08	Runx2	runt related transcription factor 2	4807	0.23
chr15_98674837_98676155	0.08	Rnd1	Rho family GTPase 1	1962	0.18
chr17_91085493_91086001	0.08	Gm47307	predicted gene, 47307	2659	0.21
chr3_14890853_14891237	0.08	Car2	carbonic anhydrase 2	4406	0.22
chr14_101842332_101842898	0.08	Lmo7	LIM domain only 7	1796	0.46
chr16_46008308_46008480	0.08	Plcxd2	phosphatidylinositol-specific phospholipase C, X domain containing 2	1824	0.32
chr13_90844060_90844211	0.08	Gm18518	predicted gene, 18518	23471	0.19
chr6_39874717_39875333	0.08	Tmem178b	transmembrane protein 178B	1954	0.27
chrX_93430021_93430176	0.08	Pola1	polymerase (DNA directed), alpha 1	60848	0.12
chr13_116298582_116298733	0.08	Isl1	ISL1 transcription factor, LIM/homeodomain	4694	0.26
chr14_27876139_27876947	0.08	Erc2	ELKS/RAB6-interacting/CAST family member 2	129	0.75
chr3_4800881_4801176	0.08	1110015O18Rik	RIKEN cDNA 1110015O18 gene	1535	0.47
chr16_20098725_20098876	0.08	Klhl24	kelch-like 24	1208	0.49
chr13_116214509_116214705	0.08	Rpl34-ps2	ribosomal protein L34, pseudogene 2	60826	0.13
chr5_146232824_146233169	0.08	Cdk8	cyclin-dependent kinase 8	1611	0.25
chr10_96623801_96623952	0.08	Btg1	BTG anti-proliferation factor 1	6322	0.22
chr16_31423409_31423642	0.08	Bdh1	3-hydroxybutyrate dehydrogenase, type 1	1245	0.34
chr12_117805814_117806560	0.08	Cdca7l	cell division cycle associated 7 like	1898	0.37
chr16_36366547_36366698	0.08	Gm15845	predicted gene 15845	448	0.53
chrX_95194864_95195015	0.08	Arhgef9	CDC42 guanine nucleotide exchange factor (GEF) 9	1513	0.42
chr10_63977869_63978469	0.08	Gm10118	predicted gene 10118	50735	0.17
chr12_113426567_113426898	0.08	Gm22175	predicted gene, 22175	1505	0.16
chr10_42273694_42273969	0.08	Foxo3	forkhead box O3	2865	0.34
chr2_103971594_103971745	0.08	Lmo2	LIM domain only 2	490	0.74
chr14_70618232_70619317	0.08	Dmtn	dematin actin binding protein	229	0.88
chrX_88113433_88114223	0.08	Il1rapl1	interleukin 1 receptor accessory protein-like 1	1817	0.46
chr1_130721109_130721366	0.08	Yod1	YOD1 deubiquitinase	3910	0.11
chr14_27380191_27380512	0.08	Gm23633	predicted gene, 23633	499	0.8
chr7_127767459_127768302	0.08	Orai3	ORAI calcium release-activated calcium modulator 3	1935	0.14
chr11_34047188_34048526	0.08	Lcp2	lymphocyte cytosolic protein 2	689	0.72
chr16_54635653_54635804	0.08	Gm23180	predicted gene, 23180	7300	0.29
chr18_56756025_56756589	0.08	Gm15345	predicted gene 15345	13410	0.18
chr16_79109471_79109622	0.08	Tmprss15	transmembrane protease, serine 15	18449	0.28
chr12_86424576_86424958	0.08	Esrrb	estrogen related receptor, beta	2884	0.33
chr2_65848318_65848473	0.08	Csrnp3	cysteine-serine-rich nuclear protein 3	2540	0.31
chr18_32539971_32540198	0.08	Gypc	glycophorin C	4666	0.22
chr10_81497570_81499812	0.08	S1pr4	sphingosine-1-phosphate receptor 4	1441	0.16
chr12_113141740_113143605	0.08	Crip2	cysteine rich protein 2	136	0.92
chr9_121403057_121404479	0.08	Trak1	trafficking protein, kinesin binding 1	290	0.91
chrX_128439905_128440056	0.08	Gm38390	predicted gene, 38390	64073	0.12
chr7_99537223_99537701	0.08	Arrb1	arrestin, beta 1	1758	0.23
chr11_37083444_37083595	0.08	Tenm2	teneurin transmembrane protein 2	139353	0.05
chr6_83171941_83172736	0.08	Gm15624	predicted gene 15624	216	0.83
chr3_88501925_88503550	0.08	Lmna	lamin A	570	0.53
chr1_182281173_182281731	0.08	Degs1	delta(4)-desaturase, sphingolipid 1	772	0.62

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfe2l1_Mafg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:2000870	regulation of progesterone secretion(GO:2000870)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.1	GO:0099558	maintenance of synapse structure(GO:0099558)
0.0	0.1	GO:0072592	oxygen metabolic process(GO:0072592)
0.0	0.2	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.3	GO:0098828	modulation of inhibitory postsynaptic potential(GO:0098828)
0.0	0.1	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0	0.1	GO:0036216	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0060060	post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:1903286	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.0	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.0	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.1	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.0	0.1	GO:0010612	regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0	0.0	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.2	GO:0071361	cellular response to ethanol(GO:0071361)
0.0	0.0	GO:0055118	negative regulation of cardiac muscle contraction(GO:0055118)
0.0	0.1	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine(GO:0001997) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.0	0.1	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.1	GO:1904177	regulation of adipose tissue development(GO:1904177)
0.0	0.1	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.0	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.0	0.3	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0002215	defense response to nematode(GO:0002215)
0.0	0.0	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.0	GO:0050904	diapedesis(GO:0050904)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:1904468	negative regulation of tumor necrosis factor secretion(GO:1904468)
0.0	0.1	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.0	0.0	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.1	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.0	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.0	GO:0035672	oligopeptide transmembrane transport(GO:0035672)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.1	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.1	GO:0071280	cellular response to copper ion(GO:0071280)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.0	GO:0070488	neutrophil aggregation(GO:0070488)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.1	GO:0070836	caveola assembly(GO:0070836)
0.0	0.0	GO:1905154	negative regulation of membrane invagination(GO:1905154)
0.0	0.0	GO:0097119	postsynaptic density protein 95 clustering(GO:0097119)
0.0	0.1	GO:0050812	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.0	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0070813	hydrogen sulfide metabolic process(GO:0070813)
0.0	0.0	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.0	0.1	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.0	GO:0017198	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0	0.0	GO:1905206	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.0	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0	0.1	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.2	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.1	GO:0097466	glycoprotein ERAD pathway(GO:0097466) response to glycoprotein(GO:1904587)
0.0	0.0	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.0	0.0	GO:0019346	homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.0	0.1	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.0	GO:1902608	regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.0	0.0	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.0	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	0.0	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.0	GO:0032512	regulation of protein phosphatase type 2B activity(GO:0032512) negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.0	0.0	GO:2000520	regulation of immunological synapse formation(GO:2000520)
0.0	0.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.0	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.0	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.0	0.1	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.1	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.1	GO:0043144	snoRNA processing(GO:0043144)
0.0	0.0	GO:0006083	acetate metabolic process(GO:0006083)
0.0	0.1	GO:0006662	glycerol ether metabolic process(GO:0006662)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.0	GO:0006538	glutamate catabolic process(GO:0006538)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1	GO:0005955	calcineurin complex(GO:0005955)
0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1	GO:0031084	BLOC-2 complex(GO:0031084)
0.1	GO:0031415	NatA complex(GO:0031415)
0.1	GO:0097418	neurofibrillary tangle(GO:0097418)
0.1	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.1	GO:0044308	axonal spine(GO:0044308)
0.1	GO:0005638	lamin filament(GO:0005638)
0.2	GO:0031045	dense core granule(GO:0031045)
0.0	GO:0005879	axonemal microtubule(GO:0005879)
0.4	GO:0048786	presynaptic active zone(GO:0048786)
0.0	GO:0044316	cone cell pedicle(GO:0044316)
0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	GO:0043159	acrosomal matrix(GO:0043159)
0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1	GO:0005833	hemoglobin complex(GO:0005833)
0.0	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1	GO:0030911	TPR domain binding(GO:0030911)
0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.1	GO:0097016	L27 domain binding(GO:0097016)
0.1	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	GO:0042284	sphingolipid delta-4 desaturase activity(GO:0042284)
0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	GO:0031721	hemoglobin alpha binding(GO:0031721)
0.1	GO:0004064	arylesterase activity(GO:0004064)
0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.4	GO:0052714	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	GO:0019961	interferon binding(GO:0019961)
0.1	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.1	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	GO:0070538	oleic acid binding(GO:0070538)
0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.2	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.1	GO:0005522	profilin binding(GO:0005522)
0.0	GO:1990190	peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	GO:0031711	bradykinin receptor binding(GO:0031711)
0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	GO:0016532	superoxide dismutase copper chaperone activity(GO:0016532)
0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.1	GO:0016937	short-branched-chain-acyl-CoA dehydrogenase activity(GO:0016937)
0.1	GO:0015216	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.2	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism