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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nfkb2

Z-value: 0.68

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Transcription factors associated with Nfkb2

Gene Symbol	Gene ID	Gene Info
Nfkb2 Ensembl NCBI MGI UniProt	ENSMUSG00000025225.8	Nfkb2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Nfkb2	chr19_46308370_46309175	2651	0.121170	0.37	3.8e-03	Click!
Nfkb2	chr19_46309210_46309553	3260	0.107330	0.27	3.5e-02	Click!
Nfkb2	chr19_46309835_46310023	3808	0.099537	0.18	1.6e-01	Click!
Nfkb2	chr19_46304094_46304245	151	0.883432	-0.16	2.2e-01	Click!
Nfkb2	chr19_46308192_46308343	2146	0.141029	0.14	2.8e-01	Click!

Activity of the Nfkb2 motif across conditions

Conditions sorted by the z-value of the Nfkb2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_70119024_70120981	3.07	Ncan	neurocan	871	0.35
chr2_143546820_143547517	3.02	Pcsk2os1	proprotein convertase subtilisin/kexin type 2, opposite strand 1	669	0.53
chr14_93888463_93888979	2.58	Pcdh9	protocadherin 9	11	0.99
chr2_65929929_65930575	2.51	Csrnp3	cysteine-serine-rich nuclear protein 3	115	0.97
chr17_25567606_25567996	2.20	Sox8	SRY (sex determining region Y)-box 8	2413	0.13
chr15_12739006_12740203	2.13	Pdzd2	PDZ domain containing 2	320	0.86
chr13_105444000_105445296	2.05	Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	1009	0.69
chr14_67236008_67239452	1.95	Ebf2	early B cell factor 2	3086	0.21
chr9_73967774_73969221	1.93	Unc13c	unc-13 homolog C	469	0.88
chr5_49284738_49286021	1.80	Kcnip4	Kv channel interacting protein 4	280	0.92
chr2_38354292_38355594	1.75	Lhx2	LIM homeobox protein 2	1141	0.41
chr1_178530778_178530954	1.70	Kif26b	kinesin family member 26B	1741	0.44
chr5_142961791_142962040	1.68	Fscn1	fascin actin-bundling protein 1	1038	0.49
chr15_59319527_59320112	1.67	Sqle	squalene epoxidase	4712	0.18
chrX_135210129_135210918	1.51	Tceal6	transcription elongation factor A (SII)-like 6	164	0.93
chr13_112289274_112289896	1.50	Ankrd55	ankyrin repeat domain 55	765	0.56
chr2_27027194_27027995	1.49	Slc2a6	solute carrier family 2 (facilitated glucose transporter), member 6	315	0.79
chr1_124045018_124046369	1.48	Dpp10	dipeptidylpeptidase 10	134	0.98
chr3_89522754_89523224	1.44	Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	2825	0.22
chr11_96987508_96988742	1.43	Sp2	Sp2 transcription factor	5166	0.1
chr10_114800824_114801254	1.43	Trhde	TRH-degrading enzyme	331	0.73
chr17_57148993_57149872	1.35	Cd70	CD70 antigen	345	0.79
chr12_79130802_79131751	1.34	Arg2	arginase type II	499	0.64
chr18_69347722_69348433	1.31	Tcf4	transcription factor 4	179	0.97
chr8_83902724_83903561	1.30	Adgrl1	adhesion G protein-coupled receptor L1	2407	0.18
chr7_79507205_79507895	1.29	Mir9-3	microRNA 9-3	2286	0.14
chr15_78717784_78718525	1.25	Elfn2	leucine rich repeat and fibronectin type III, extracellular 2	41	0.97
chr10_80179768_80180422	1.19	Efna2	ephrin A2	613	0.51
chr15_102959654_102960750	1.19	Hoxc11	homeobox C11	5775	0.08
chr6_110645148_110646464	1.17	Gm20387	predicted gene 20387	110	0.67
chr5_28465805_28466194	1.15	9530036O11Rik	RIKEN cDNA 9530036O11Rik	985	0.44
chr11_11115362_11116603	1.15	Vwc2	von Willebrand factor C domain containing 2	131	0.97
chr1_74802832_74804032	1.11	Wnt10a	wingless-type MMTV integration site family, member 10A	10069	0.11
chr4_140647825_140648405	1.10	Arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like	635	0.68
chr15_98951099_98951690	1.09	Gm49450	predicted gene, 49450	2157	0.13
chr14_88469423_88470289	1.09	Pcdh20	protocadherin 20	1490	0.47
chr11_93100564_93101210	1.07	Car10	carbonic anhydrase 10	1597	0.56
chrX_102069269_102069420	1.07	Rtl5	retrotransposon Gag like 5	1744	0.27
chr11_96297868_96298678	1.06	Hoxb6	homeobox B6	898	0.3
chr7_131966504_131967699	1.06	Gpr26	G protein-coupled receptor 26	641	0.75
chr18_83635368_83635622	1.05	Gm31621	predicted gene, 31621	2431	0.28
chr7_45869909_45870408	1.03	Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	271	0.77
chr1_19104045_19104891	1.03	Gm15825	predicted gene 15825	372	0.8
chr5_90758918_90760166	1.00	Cxcl5	chemokine (C-X-C motif) ligand 5	164	0.91
chr11_102081725_102082491	0.99	Mpp2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	311	0.79
chr7_25007594_25007745	0.95	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide	1711	0.22
chr14_58150040_58150734	0.94	Gm17109	predicted gene 17109	44258	0.14
chr11_69800320_69800731	0.93	Fgf11	fibroblast growth factor 11	1191	0.19
chr3_88458101_88459325	0.92	Sema4a	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	163	0.88
chr4_154649328_154649479	0.92	Gm27202	predicted gene 27202	3702	0.15
chr7_74012361_74013617	0.92	St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	685	0.71
chr15_73668219_73668370	0.92	1700010B13Rik	RIKEN cDNA 1700010B13 gene	22420	0.14
chr8_126140788_126141154	0.91	Slc35f3	solute carrier family 35, member F3	1589	0.49
chr2_18056600_18056751	0.91	1810059C17Rik	RIKEN cDNA 1810059C17 gene	62	0.92
chr2_152951095_152951539	0.90	Dusp15	dual specificity phosphatase-like 15	139	0.93
chr19_16135060_16135656	0.89	Gnaq	guanine nucleotide binding protein, alpha q polypeptide	2062	0.35
chr11_34315414_34316667	0.89	Insyn2b	inhibitory synaptic factor family member 2B	1218	0.45
chr5_90902965_90904167	0.88	Cxcl2	chemokine (C-X-C motif) ligand 2	305	0.84
chr11_98980727_98980878	0.88	Gjd3	gap junction protein, delta 3	2214	0.17
chr9_13301218_13302233	0.87	Maml2	mastermind like transcriptional coactivator 2	3768	0.19
chr1_177640225_177640394	0.87	2310043L19Rik	RIKEN cDNA 2310043L19 gene	2634	0.25
chr2_163602380_163602998	0.87	Ttpal	tocopherol (alpha) transfer protein-like	126	0.95
chr6_55455310_55456012	0.86	Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	3484	0.26
chr3_66976883_66977353	0.86	Shox2	short stature homeobox 2	1329	0.41
chr8_26848235_26848453	0.84	2310008N11Rik	RIKEN cDNA 2310008N11 gene	6345	0.21
chr1_5018491_5020565	0.84	Rgs20	regulator of G-protein signaling 20	11	0.98
chr3_66219854_66220300	0.83	Ptx3	pentraxin related gene	167	0.95
chr2_33626557_33626708	0.83	Lmx1b	LIM homeobox transcription factor 1 beta	5651	0.16
chr2_33593442_33593593	0.83	Gm38011	predicted gene, 38011	20881	0.15
chr7_126848132_126848884	0.83	Doc2a	double C2, alpha	253	0.76
chr11_58866994_58868023	0.83	2810021J22Rik	RIKEN cDNA 2810021J22 gene	241	0.79
chr12_98577628_98578516	0.83	Kcnk10	potassium channel, subfamily K, member 10	238	0.9
chr5_96373327_96373478	0.81	Fras1	Fraser extracellular matrix complex subunit 1	553	0.83
chr5_113490881_113491656	0.81	Wscd2	WSC domain containing 2	516	0.83
chr1_12991432_12992703	0.80	Slco5a1	solute carrier organic anion transporter family, member 5A1	583	0.78
chr10_18341675_18342214	0.78	Gm18942	predicted gene, 18942	4703	0.22
chr10_81251490_81251641	0.76	Matk	megakaryocyte-associated tyrosine kinase	1370	0.17
chr12_89811728_89812295	0.74	Nrxn3	neurexin III	397	0.92
chr7_43489310_43490670	0.74	Iglon5	IgLON family member 5	85	0.92
chr1_119051596_119052429	0.73	Gli2	GLI-Kruppel family member GLI2	1327	0.47
chr11_44632092_44632243	0.73	Ebf1	early B cell factor 1	10406	0.17
chr11_116809628_116809779	0.72	Mxra7	matrix-remodelling associated 7	18300	0.1
chr17_34038427_34040461	0.72	Col11a2	collagen, type XI, alpha 2	7	0.9
chr16_97168581_97168970	0.72	Dscam	DS cell adhesion molecule	1977	0.47
chr1_172482102_172483290	0.72	Igsf9	immunoglobulin superfamily, member 9	382	0.75
chr7_45795764_45796042	0.72	Lmtk3	lemur tyrosine kinase 3	8155	0.07
chr1_191224508_191225332	0.71	D730003I15Rik	RIKEN cDNA D730003I15 gene	446	0.76
chr3_3308823_3309359	0.70	Gm8747	predicted gene 8747	42064	0.2
chr19_10356843_10356994	0.70	Syt7	synaptotagmin VII	32172	0.12
chr15_103519597_103520253	0.69	Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	3793	0.17
chr2_102450383_102451888	0.69	Fjx1	four jointed box 1	1364	0.51
chr4_126277866_126278017	0.69	Col8a2	collagen, type VIII, alpha 2	8852	0.12
chr15_103105344_103105529	0.69	Gm28265	predicted gene 28265	834	0.41
chr2_150361232_150361675	0.68	3300002I08Rik	RIKEN cDNA 3300002I08 gene	1280	0.35
chr15_84301565_84301928	0.68	Gm22890	predicted gene, 22890	21606	0.13
chr10_59221970_59222690	0.67	Sowahc	sosondowah ankyrin repeat domain family member C	377	0.54
chr6_86051805_86052622	0.66	Add2	adducin 2 (beta)	35	0.96
chr2_77816072_77817449	0.66	Zfp385b	zinc finger protein 385B	56	0.98
chr11_118568846_118570341	0.66	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	317	0.91
chr9_119092635_119093830	0.66	Plcd1	phospholipase C, delta 1	270	0.87
chr15_81696545_81697665	0.65	Chadl	chondroadherin-like	182	0.9
chr4_102087325_102088593	0.64	Pde4b	phosphodiesterase 4B, cAMP specific	218	0.95
chr15_102980564_102980932	0.63	Hoxc9	homeobox C9	3716	0.09
chr8_111742802_111743840	0.63	Bcar1	breast cancer anti-estrogen resistance 1	488	0.8
chr18_42401018_42401905	0.63	Pou4f3	POU domain, class 4, transcription factor 3	6386	0.2
chr10_127187269_127187420	0.63	Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	121	0.91
chr2_27122326_27122477	0.62	Adamtsl2	ADAMTS-like 2	17738	0.11
chr19_55749292_55750940	0.62	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	7271	0.3
chr9_41474743_41475732	0.62	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	177	0.72
chr11_3910794_3911677	0.62	Slc35e4	solute carrier family 35, member E4	3429	0.13
chr13_42709240_42709536	0.61	Phactr1	phosphatase and actin regulator 1	155	0.97
chr4_129966249_129966400	0.61	1700003M07Rik	RIKEN cDNA 1700003M07 gene	5516	0.14
chr17_28144735_28145006	0.61	Scube3	signal peptide, CUB domain, EGF-like 3	2344	0.18
chr12_72844062_72844595	0.60	Gm33785	predicted gene, 33785	26616	0.16
chr11_97627602_97627753	0.60	Epop	elongin BC and polycomb repressive complex 2 associated protein	2025	0.18
chr2_25580658_25582212	0.60	Ajm1	apical junction component 1	293	0.72
chr5_125158383_125159717	0.59	Ncor2	nuclear receptor co-repressor 2	20003	0.19
chrX_73411302_73411931	0.59	Zfp92	zinc finger protein 92	56	0.66
chr19_59468752_59469845	0.58	Emx2	empty spiracles homeobox 2	6496	0.17
chr7_45417677_45418655	0.58	AC151602.1	luteinizing hormone beta	187	0.8
chr1_129275124_129275766	0.58	Thsd7b	thrombospondin, type I, domain containing 7B	1960	0.39
chr10_94311604_94312850	0.58	Tmcc3	transmembrane and coiled coil domains 3	90	0.97
chr5_67633750_67634259	0.57	Gm42735	predicted gene 42735	1304	0.3
chr11_5255980_5256131	0.57	Gm25142	predicted gene, 25142	4205	0.19
chr2_25460160_25461436	0.57	Paxx	non-homologous end joining factor	129	0.89
chr11_109297097_109298424	0.57	Rgs9	regulator of G-protein signaling 9	306	0.9
chr7_46099780_46100565	0.56	Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	65	0.95
chr19_5093217_5093838	0.56	Yif1a	Yip1 interacting factor homolog A (S. cerevisiae)	4599	0.07
chr7_101419184_101419783	0.56	Pde2a	phosphodiesterase 2A, cGMP-stimulated	2208	0.21
chr16_91012571_91012722	0.55	4930404I05Rik	RIKEN cDNA 4930404I05 gene	1075	0.29
chr10_102160210_102160629	0.55	Mgat4c	MGAT4 family, member C	1340	0.6
chr10_127619791_127621096	0.55	Lrp1	low density lipoprotein receptor-related protein 1	479	0.65
chr9_106456260_106457377	0.54	Pcbp4	poly(rC) binding protein 4	721	0.42
chr4_121039154_121040672	0.53	Col9a2	collagen, type IX, alpha 2	165	0.92
chr18_38216257_38217428	0.53	2010320O07Rik	RIKEN cDNA 2010320O07 gene	3138	0.16
chr2_32311532_32312331	0.53	Dnm1	dynamin 1	958	0.33
chr11_35120980_35122375	0.52	Slit3	slit guidance ligand 3	453	0.89
chr5_117087628_117088305	0.52	Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	10845	0.15
chr2_152907676_152907827	0.52	Mylk2	myosin, light polypeptide kinase 2, skeletal muscle	3601	0.15
chr11_98950065_98950283	0.52	Gm22061	predicted gene, 22061	3730	0.13
chr6_37297951_37298469	0.52	Dgki	diacylglycerol kinase, iota	1427	0.53
chr5_121823215_121823366	0.52	Mir7031	microRNA 7031	4017	0.12
chr2_35619545_35620730	0.52	Dab2ip	disabled 2 interacting protein	1844	0.38
chr2_27460067_27460218	0.52	Brd3	bromodomain containing 3	3974	0.16
chr2_32759044_32759195	0.51	Tor2a	torsin family 2, member A	1176	0.25
chr4_155252152_155252689	0.51	Faap20	Fanconi anemia core complex associated protein 20	1724	0.32
chr16_45723390_45724960	0.50	Tagln3	transgelin 3	433	0.77
chr5_99726980_99727219	0.50	Rasgef1b	RasGEF domain family, member 1B	1713	0.32
chr16_91229951_91230102	0.50	Olig2	oligodendrocyte transcription factor 2	4569	0.14
chr16_77236731_77239778	0.50	Mir99ahg	Mir99a and Mirlet7c-1 host gene (non-protein coding)	1935	0.4
chr8_105699776_105699927	0.50	Acd	adrenocortical dysplasia	30	0.93
chr8_24296964_24297158	0.49	Gm45164	predicted gene 45164	62375	0.11
chr10_127488582_127488733	0.49	R3hdm2	R3H domain containing 2	3175	0.14
chr11_96697035_96697186	0.49	Skap1	src family associated phosphoprotein 1	11125	0.17
chrX_7863281_7863432	0.49	Otud5	OTU domain containing 5	7629	0.08
chr1_34801752_34802642	0.49	Arhgef4	Rho guanine nucleotide exchange factor (GEF) 4	403	0.78
chr7_80320493_80320644	0.48	Rccd1	RCC1 domain containing 1	471	0.66
chr5_143293458_143294037	0.48	Zfp853	zinc finger protein 853	124	0.91
chr12_12938033_12939196	0.48	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	2002	0.23
chr5_69340137_69340288	0.48	Gm24368	predicted gene, 24368	571	0.63
chr15_101253842_101254216	0.48	Nr4a1	nuclear receptor subfamily 4, group A, member 1	240	0.86
chr12_70830034_70830209	0.47	Frmd6	FERM domain containing 6	4432	0.2
chrX_20290867_20291587	0.47	Slc9a7	solute carrier family 9 (sodium/hydrogen exchanger), member 7	543	0.77
chr9_37783109_37783351	0.47	Olfr875	olfactory receptor 875	10593	0.1
chr15_84444030_84444699	0.47	Shisal1	shisa like 1	667	0.75
chr15_103005378_103006088	0.46	Hoxc6	homeobox C6	3840	0.1
chr4_134496639_134497966	0.46	Paqr7	progestin and adipoQ receptor family member VII	261	0.84
chr2_164961062_164961920	0.46	Slc12a5	solute carrier family 12, member 5	645	0.6
chr17_56466771_56466941	0.46	Ptprs	protein tyrosine phosphatase, receptor type, S	4640	0.17
chr1_69105258_69106691	0.46	Gm16076	predicted gene 16076	766	0.61
chr11_95057837_95057988	0.46	Itga3	integrin alpha 3	1717	0.25
chr9_102722581_102723136	0.45	Amotl2	angiomotin-like 2	324	0.83
chr4_127235958_127237081	0.45	Smim12	small integral membrane protein 12	7265	0.16
chr1_133049808_133049959	0.45	Pik3c2b	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	3871	0.17
chr19_46063703_46063854	0.45	Pprc1	peroxisome proliferative activated receptor, gamma, coactivator-related 1	4056	0.15
chr4_28816938_28817154	0.44	Epha7	Eph receptor A7	1617	0.37
chr3_45432245_45432549	0.44	Gm2136	predicted gene 2136	5983	0.17
chr3_10329449_10329600	0.44	Impa1	inositol (myo)-1(or 4)-monophosphatase 1	1608	0.22
chr6_114133449_114133914	0.44	Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	2262	0.31
chr2_3419168_3419605	0.44	Meig1	meiosis expressed gene 1	257	0.87
chr9_55326922_55327600	0.43	Tmem266	transmembrane protein 266	312	0.58
chr17_26953045_26954307	0.43	Syngap1	synaptic Ras GTPase activating protein 1 homolog (rat)	790	0.36
chr14_14345697_14346878	0.43	Il3ra	interleukin 3 receptor, alpha chain	12	0.94
chr2_102552573_102552724	0.42	Pamr1	peptidase domain containing associated with muscle regeneration 1	2499	0.38
chr2_72516060_72516494	0.41	Rps13-ps8	ribosmal protein S13, pseudogene 8	28935	0.16
chr13_97248203_97248451	0.41	Enc1	ectodermal-neural cortex 1	7222	0.17
chr13_109926306_109927455	0.41	Pde4d	phosphodiesterase 4D, cAMP specific	36	0.98
chr2_164388819_164390055	0.41	Slpi	secretory leukocyte peptidase inhibitor	342	0.77
chrX_36111786_36112920	0.40	Il13ra1	interleukin 13 receptor, alpha 1	243	0.94
chr5_147747988_147748815	0.40	Gm43156	predicted gene 43156	2885	0.27
chr11_119156502_119158281	0.40	Mir6934	microRNA 6934	3254	0.17
chr7_29224845_29225704	0.39	Kcnk6	potassium inwardly-rectifying channel, subfamily K, member 6	6033	0.09
chr15_79802268_79802553	0.39	Nptxr	neuronal pentraxin receptor	2299	0.17
chr19_46320592_46320743	0.39	Psd	pleckstrin and Sec7 domain containing	2576	0.12
chr3_11213105_11213577	0.39	Gm22547	predicted gene, 22547	59004	0.16
chr16_42782105_42782459	0.39	4932412D23Rik	RIKEN cDNA 4932412D23 gene	93305	0.08
chr7_74006482_74006835	0.39	St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	7016	0.2
chr10_105689563_105689778	0.39	n-R5s80	nuclear encoded rRNA 5S 80	114527	0.05
chr4_124576262_124576413	0.38	4933407E24Rik	RIKEN cDNA 4933407E24 gene	7147	0.19
chr8_26268626_26269363	0.38	Gm31727	predicted gene, 31727	2017	0.23

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfkb2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.3	1.3	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.3	1.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.3	1.0	GO:0030070	insulin processing(GO:0030070)
0.3	0.9	GO:0010963	regulation of L-arginine import(GO:0010963)
0.3	0.8	GO:0052203	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.2	0.7	GO:0072092	ureteric bud invasion(GO:0072092)
0.2	0.8	GO:0030035	microspike assembly(GO:0030035)
0.2	0.5	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.2	1.2	GO:0042118	endothelial cell activation(GO:0042118)
0.2	0.5	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.2	0.3	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.1	0.4	GO:0015888	thiamine transport(GO:0015888)
0.1	0.7	GO:0060023	soft palate development(GO:0060023)
0.1	1.2	GO:0035428	hexose transmembrane transport(GO:0035428)
0.1	0.4	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.1	0.4	GO:0035962	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.1	0.5	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.1	0.2	GO:0072197	ureter morphogenesis(GO:0072197)
0.1	0.4	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1	0.3	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1	0.6	GO:1903054	negative regulation of extracellular matrix organization(GO:1903054)
0.1	1.0	GO:0051823	regulation of synapse structural plasticity(GO:0051823)
0.1	0.3	GO:0060060	post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1	0.6	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.1	0.3	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.4	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.1	0.3	GO:0032289	central nervous system myelin formation(GO:0032289)
0.1	0.8	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.1	0.3	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.1	0.2	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.1	0.4	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1	0.4	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1	0.3	GO:0051665	membrane raft localization(GO:0051665)
0.1	1.3	GO:0021978	telencephalon regionalization(GO:0021978)
0.1	0.3	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1	0.3	GO:1903802	L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.1	0.9	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.1	0.2	GO:2000834	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.1	0.2	GO:0002930	trabecular meshwork development(GO:0002930)
0.1	0.2	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1	0.2	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.3	GO:0046959	habituation(GO:0046959)
0.1	0.1	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
0.1	0.6	GO:0048012	hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.1	0.3	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1	0.2	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.1	0.9	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1	0.2	GO:0021780	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1	0.3	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.1	4.1	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.1	1.5	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1	0.2	GO:0035553	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1	0.3	GO:0045634	regulation of melanocyte differentiation(GO:0045634)
0.1	0.2	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.1	0.1	GO:0097104	postsynaptic membrane assembly(GO:0097104)
0.1	0.1	GO:0061642	chemoattraction of axon(GO:0061642)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	1.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	1.0	GO:0043171	peptide catabolic process(GO:0043171)
0.0	0.7	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.2	GO:0060732	positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0	0.1	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.0	0.1	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0090135	actin filament branching(GO:0090135)
0.0	0.2	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.0	GO:1903416	response to glycoside(GO:1903416)
0.0	0.4	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.6	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.9	GO:1902668	negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0	0.2	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.2	GO:2000618	regulation of histone H4-K16 acetylation(GO:2000618)
0.0	0.2	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.0	0.1	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.1	GO:0015766	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.3	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.2	GO:0090385	phagosome-lysosome fusion(GO:0090385)
0.0	0.1	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.0	1.3	GO:0030514	negative regulation of BMP signaling pathway(GO:0030514)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.1	GO:2000821	regulation of grooming behavior(GO:2000821)
0.0	0.1	GO:0021586	pons maturation(GO:0021586)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.3	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.1	GO:0030908	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0	0.1	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.3	GO:0048733	sebaceous gland development(GO:0048733)
0.0	0.8	GO:0010107	potassium ion import(GO:0010107)
0.0	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.3	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.2	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0	0.2	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.3	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.0	0.2	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.1	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.2	GO:0031937	positive regulation of chromatin silencing(GO:0031937)
0.0	0.2	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.0	0.1	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.1	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.2	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.3	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.1	GO:0031446	regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.0	0.1	GO:0051795	positive regulation of catagen(GO:0051795)
0.0	0.1	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.0	0.1	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.0	0.0	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.1	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.1	GO:0016198	axon choice point recognition(GO:0016198)
0.0	0.2	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.1	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.0	GO:0097107	postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107)
0.0	0.6	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.0	GO:0060126	somatotropin secreting cell differentiation(GO:0060126)
0.0	0.2	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.7	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.4	GO:0010842	retina layer formation(GO:0010842)
0.0	0.3	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0	0.2	GO:0006702	androgen biosynthetic process(GO:0006702)
0.0	0.6	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0072079	nephron tubule formation(GO:0072079)
0.0	0.1	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.1	GO:0038031	non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0	0.1	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0043587	tongue morphogenesis(GO:0043587)
0.0	0.1	GO:0021562	vestibulocochlear nerve development(GO:0021562)
0.0	0.0	GO:0036490	regulation of translation in response to endoplasmic reticulum stress(GO:0036490) regulation of translation initiation in response to endoplasmic reticulum stress(GO:0036491) eiF2alpha phosphorylation in response to endoplasmic reticulum stress(GO:0036492) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0	0.5	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
0.0	0.2	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.1	GO:0048664	neuron fate determination(GO:0048664)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.1	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.1	GO:0046340	diacylglycerol catabolic process(GO:0046340)
0.0	0.1	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.2	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.0	0.1	GO:1902065	response to L-glutamate(GO:1902065)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:1900452	regulation of long term synaptic depression(GO:1900452)
0.0	0.1	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0	0.0	GO:2000977	regulation of forebrain neuron differentiation(GO:2000977)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.0	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.0	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0045607	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.1	GO:0043320	natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.2	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	0.1	GO:2000288	positive regulation of myoblast proliferation(GO:2000288)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.2	GO:2000479	regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.7	GO:1901379	regulation of potassium ion transmembrane transport(GO:1901379)
0.0	0.0	GO:0090306	spindle assembly involved in meiosis(GO:0090306)
0.0	0.0	GO:0003096	renal sodium ion transport(GO:0003096) glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0	0.3	GO:0048266	behavioral response to pain(GO:0048266)
0.0	0.2	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652)
0.0	0.0	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.0	0.1	GO:0042940	D-amino acid transport(GO:0042940)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0051013	microtubule severing(GO:0051013)
0.0	0.1	GO:0070831	basement membrane assembly(GO:0070831)
0.0	1.1	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0	0.1	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.0	0.0	GO:2001185	regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.0	0.1	GO:0031643	positive regulation of myelination(GO:0031643)
0.0	0.1	GO:0099515	actin filament-based transport(GO:0099515)
0.0	0.0	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.0	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.0	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0	0.0	GO:1902513	regulation of organelle transport along microtubule(GO:1902513)
0.0	0.1	GO:2000010	positive regulation of protein localization to cell surface(GO:2000010)
0.0	1.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.1	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.0	0.2	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.0	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.8	GO:0060021	palate development(GO:0060021)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.0	GO:0033239	negative regulation of cellular amine metabolic process(GO:0033239)
0.0	0.1	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.3	GO:0009409	response to cold(GO:0009409)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.3	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.0	GO:0090394	negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0	0.1	GO:0015813	L-glutamate transport(GO:0015813)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:2000254	regulation of male germ cell proliferation(GO:2000254)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:1901223	negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0	0.1	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.3	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.0	GO:0071504	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.0	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0	0.0	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.2	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	0.1	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.0	GO:0034163	regulation of toll-like receptor 9 signaling pathway(GO:0034163) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	0.0	GO:0009642	response to light intensity(GO:0009642)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0070813	hydrogen sulfide metabolic process(GO:0070813)
0.0	0.0	GO:0045585	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0044393	microspike(GO:0044393)
0.2	0.5	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.2	0.5	GO:0005594	collagen type IX trimer(GO:0005594)
0.2	1.2	GO:0043203	axon hillock(GO:0043203)
0.1	0.4	GO:0097451	glial limiting end-foot(GO:0097451)
0.1	0.3	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.1	0.6	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1	1.0	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	0.4	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.1	0.3	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1	0.2	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.1	0.5	GO:0070187	telosome(GO:0070187)
0.1	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	1.1	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.8	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.1	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1	0.6	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	3.5	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	0.0	GO:0035061	interchromatin granule(GO:0035061)
0.0	0.3	GO:0043196	varicosity(GO:0043196)
0.0	0.4	GO:0097542	ciliary tip(GO:0097542)
0.0	0.6	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.6	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.2	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.2	GO:0097449	astrocyte projection(GO:0097449)
0.0	0.3	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	1.1	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0034464	BBSome(GO:0034464)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.4	GO:0031528	microvillus membrane(GO:0031528)
0.0	2.7	GO:0043204	perikaryon(GO:0043204)
0.0	1.2	GO:0042734	presynaptic membrane(GO:0042734)
0.0	3.2	GO:0030426	growth cone(GO:0030426)
0.0	0.3	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.1	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.3	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.2	GO:0043657	host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0	0.1	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0031501	mannosyltransferase complex(GO:0031501)
0.0	0.8	GO:0005871	kinesin complex(GO:0005871)
0.0	0.0	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	1.4	GO:0055037	recycling endosome(GO:0055037)
0.0	0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.0	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0	0.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.2	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.0	GO:0005767	secondary lysosome(GO:0005767)
0.0	0.0	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0	0.1	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0071953	elastic fiber(GO:0071953)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.8	GO:0019992	diacylglycerol binding(GO:0019992)
0.2	1.0	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2	0.8	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1	1.9	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	1.3	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.1	1.4	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.1	1.4	GO:0051378	serotonin binding(GO:0051378)
0.1	0.4	GO:0070905	serine binding(GO:0070905)
0.1	0.4	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.1	0.9	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.1	0.8	GO:0046790	virion binding(GO:0046790)
0.1	0.3	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.1	1.1	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.1	0.3	GO:0043237	laminin-1 binding(GO:0043237)
0.1	0.5	GO:0048495	Roundabout binding(GO:0048495)
0.1	0.9	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1	1.1	GO:0005351	sugar:proton symporter activity(GO:0005351)
0.1	0.2	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1	0.4	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.6	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.1	0.5	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.1	0.2	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1	0.9	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.1	0.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	0.3	GO:0071723	lipopeptide binding(GO:0071723)
0.1	0.9	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.1	0.3	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	0.3	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.1	0.7	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1	0.6	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1	0.2	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.1	1.5	GO:0050699	WW domain binding(GO:0050699)
0.1	1.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	0.2	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.1	0.4	GO:0004385	guanylate kinase activity(GO:0004385)
0.1	0.2	GO:0031493	nucleosomal histone binding(GO:0031493)
0.0	1.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.6	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	1.6	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	1.3	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.9	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.5	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.4	GO:0015385	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	0.1	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.8	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.3	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0103116	alpha-D-galactofuranose transporter activity(GO:0103116)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0038064	collagen receptor activity(GO:0038064)
0.0	0.1	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0	1.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.6	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.2	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.1	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.4	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.6	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.3	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.5	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.3	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0004970	ionotropic glutamate receptor activity(GO:0004970)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0043199	sulfate binding(GO:0043199)
0.0	0.2	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.2	GO:0031005	filamin binding(GO:0031005)
0.0	0.7	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.2	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.1	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.0	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.1	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0	0.2	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.0	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.0	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.6	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.2	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.0	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0015197	peptide transporter activity(GO:0015197)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.4	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	0.4	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	0.4	ST G ALPHA I PATHWAY	G alpha i Pathway
0.1	1.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	0.4	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	1.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	3.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.8	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.9	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.8	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	0.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.4	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.4	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	1.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.2	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	0.3	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.1	0.5	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.1	1.0	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	1.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	0.9	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.1	1.1	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	0.3	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	0.9	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	1.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	0.8	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	0.6	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.1	1.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.8	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.1	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	1.2	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.4	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.4	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.3	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.4	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.1	REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	Genes involved in Cytokine Signaling in Immune system
0.0	0.7	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.1	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.2	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.3	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.0	0.2	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.2	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.5	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.1	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	0.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.1	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins