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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nr0b1

Z-value: 0.51

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Transcription factors associated with Nr0b1

Gene Symbol	Gene ID	Gene Info
Nr0b1 Ensembl NCBI MGI UniProt	ENSMUSG00000025056.4	Nr0b1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Nr0b1	chrX_86191680_86192868	510	0.816189	0.25	5.5e-02	Click!

Activity of the Nr0b1 motif across conditions

Conditions sorted by the z-value of the Nr0b1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_119803355_119804193	0.63	1700021F13Rik	RIKEN cDNA 1700021F13 gene	3893	0.21
chr2_172936311_172937024	0.56	Bmp7	bone morphogenetic protein 7	3425	0.23
chr17_32165675_32166119	0.51	Notch3	notch 3	955	0.45
chr3_9347262_9347787	0.48	C030034L19Rik	RIKEN cDNA C030034L19 gene	55540	0.13
chr6_63256981_63257723	0.46	9330118I20Rik	RIKEN cDNA 9330118I20 gene	273	0.71
chr11_5802324_5803834	0.37	Pgam2	phosphoglycerate mutase 2	654	0.56
chr18_76544225_76544908	0.36	Gm31933	predicted gene, 31933	88304	0.1
chr4_134370897_134371720	0.34	Extl1	exostosin-like glycosyltransferase 1	1250	0.33
chr14_54986330_54986529	0.33	Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	989	0.26
chr10_78787171_78788340	0.33	Slc1a6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	7053	0.14
chr16_94721948_94722518	0.33	Gm41505	predicted gene, 41505	339	0.89
chr17_26840808_26841709	0.32	Nkx2-5	NK2 homeobox 5	307	0.83
chr6_29434692_29436459	0.31	Flnc	filamin C, gamma	2299	0.16
chr9_53402629_53402979	0.30	4930550C14Rik	RIKEN cDNA 4930550C14 gene	479	0.73
chr2_167239298_167240893	0.30	Ptgis	prostaglandin I2 (prostacyclin) synthase	494	0.75
chr3_138066011_138066302	0.30	1110002E22Rik	RIKEN cDNA 1110002E22 gene	1104	0.33
chr15_54278043_54279091	0.29	Tnfrsf11b	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	83	0.98
chr14_55826099_55826996	0.29	Nfatc4	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4	491	0.63
chr9_21851806_21852608	0.29	Dock6	dedicator of cytokinesis 6	409	0.74
chr8_57324050_57324269	0.29	Hand2os1	Hand2, opposite strand 1	74	0.96
chr10_109921017_109921811	0.28	Nav3	neuron navigator 3	17391	0.27
chr6_54329128_54329297	0.28	9130019P16Rik	RIKEN cDNA 9130019P16 gene	1871	0.29
chr16_4522019_4522667	0.28	Srl	sarcalumenin	720	0.62
chr16_4641802_4643186	0.28	Dnaja3	DnaJ heat shock protein family (Hsp40) member A3	2505	0.16
chr10_22813360_22814229	0.28	Gm10824	predicted gene 10824	1955	0.28
chr13_93612831_93613054	0.28	Gm15622	predicted gene 15622	12440	0.16
chr13_46419789_46420118	0.27	Rbm24	RNA binding motif protein 24	139	0.97
chr7_112225854_112227329	0.27	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	701	0.78
chr3_85186481_85187125	0.27	Gm38313	predicted gene, 38313	9644	0.24
chr2_30995683_30996883	0.27	Usp20	ubiquitin specific peptidase 20	235	0.9
chr15_8279541_8279705	0.26	Cplane1	ciliogenesis and planar polarity effector 1	32520	0.18
chr6_82772676_82772834	0.26	Hk2	hexokinase 2	233	0.9
chr1_162219410_162219749	0.26	Dnm3os	dynamin 3, opposite strand	289	0.86
chr3_34795242_34796350	0.26	Gm38509	predicted gene, 38509	23721	0.17
chr7_25787527_25787868	0.26	Axl	AXL receptor tyrosine kinase	125	0.92
chr9_95256675_95257394	0.25	Slc9a9	solute carrier family 9 (sodium/hydrogen exchanger), member 9	135348	0.04
chr4_126627040_126627629	0.25	5730409E04Rik	RIKEN cDNA 5730409E04Rik gene	17480	0.12
chr11_102606785_102607497	0.25	Fzd2	frizzled class receptor 2	2745	0.14
chr1_134036991_134037429	0.25	Fmod	fibromodulin	44	0.97
chr3_138069501_138070764	0.25	1110002E22Rik	RIKEN cDNA 1110002E22 gene	1465	0.3
chr9_77345728_77346390	0.25	Mlip	muscular LMNA-interacting protein	1734	0.32
chr1_69107020_69107405	0.25	Gm16076	predicted gene 16076	472	0.52
chr5_19228089_19228240	0.25	Magi2	membrane associated guanylate kinase, WW and PDZ domain containing 2	767	0.56
chr3_82144651_82145810	0.25	Gucy1a1	guanylate cyclase 1, soluble, alpha 1	157	0.96
chr8_48843313_48843722	0.24	Gm19744	predicted gene, 19744	148	0.81
chr6_53288842_53289356	0.24	Creb5	cAMP responsive element binding protein 5	1324	0.55
chr2_85049344_85049658	0.24	Tnks1bp1	tankyrase 1 binding protein 1	959	0.42
chr2_110361610_110361920	0.24	Fibin	fin bud initiation factor homolog (zebrafish)	1418	0.47
chr13_38153771_38154277	0.23	Gm10129	predicted gene 10129	2232	0.25
chr17_11912724_11913972	0.23	Prkn	parkin RBR E3 ubiquitin protein ligase	68138	0.13
chr3_84189998_84191469	0.23	Trim2	tripartite motif-containing 2	210	0.94
chr19_11818257_11818813	0.23	Stx3	syntaxin 3	186	0.9
chr2_79646122_79646273	0.23	Itprid2	ITPR interacting domain containing 2	7015	0.28
chr19_4439491_4439665	0.23	A930001C03Rik	RIKEN cDNA A930001C03 gene	19	0.64
chr8_81856918_81857264	0.23	Inpp4b	inositol polyphosphate-4-phosphatase, type II	723	0.73
chr7_107665595_107666983	0.22	Ppfibp2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	978	0.52
chrX_12116163_12116355	0.22	Bcor	BCL6 interacting corepressor	12091	0.26
chr8_102780577_102781067	0.22	Gm45258	predicted gene 45258	220	0.93
chr13_103355936_103356429	0.22	Gm5454	predicted gene 5454	70	0.97
chr2_31313954_31314959	0.22	Hmcn2	hemicentin 2	41	0.98
chr5_18360537_18360783	0.22	Gnai1	guanine nucleotide binding protein (G protein), alpha inhibiting 1	305	0.93
chr5_132541084_132542037	0.22	Auts2	autism susceptibility candidate 2	263	0.87
chr8_22507762_22508195	0.22	Slc20a2	solute carrier family 20, member 2	1752	0.29
chr14_46389448_46390599	0.22	Bmp4	bone morphogenetic protein 4	512	0.7
chr19_53808045_53808428	0.22	Rbm20	RNA binding motif protein 20	14928	0.16
chr17_42975571_42975917	0.22	Tnfrsf21	tumor necrosis factor receptor superfamily, member 21	40811	0.19
chr6_138171729_138171880	0.22	Mgst1	microsomal glutathione S-transferase 1	28950	0.23
chr13_74362852_74363978	0.22	Lrrc14b	leucine rich repeat containing 14B	590	0.54
chr6_4506970_4507670	0.22	Gm43921	predicted gene, 43921	1233	0.34
chr11_116885438_116886127	0.22	Mfsd11	major facilitator superfamily domain containing 11	17414	0.12
chr7_142472156_142472970	0.22	Lsp1	lymphocyte specific 1	412	0.73
chr2_91120847_91121416	0.22	Mybpc3	myosin binding protein C, cardiac	2987	0.16
chr12_108837523_108838185	0.21	Slc25a47	solute carrier family 25, member 47	790	0.33
chr15_89557488_89558668	0.21	Shank3	SH3 and multiple ankyrin repeat domains 3	1376	0.31
chr5_13280340_13280537	0.21	Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	116346	0.06
chr2_30902329_30903582	0.21	Ptges	prostaglandin E synthase	342	0.83
chr2_163285470_163285918	0.21	Tox2	TOX high mobility group box family member 2	34684	0.16
chr1_134513098_134514080	0.21	Gm15454	predicted gene 15454	4492	0.12
chr10_111419452_111420510	0.21	Nap1l1	nucleosome assembly protein 1-like 1	53242	0.1
chr17_66232919_66233799	0.21	Gm49932	predicted gene, 49932	1586	0.29
chr18_58210827_58211095	0.21	Fbn2	fibrillin 2	474	0.86
chr16_14705845_14706609	0.21	Snai2	snail family zinc finger 2	375	0.9
chr16_35659651_35660734	0.21	Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	757	0.67
chr17_68002299_68002969	0.21	Arhgap28	Rho GTPase activating protein 28	1486	0.54
chr2_4298620_4299406	0.21	Frmd4a	FERM domain containing 4A	1505	0.32
chr8_120231782_120232001	0.21	Gse1	genetic suppressor element 1, coiled-coil protein	3435	0.2
chr5_125139990_125141281	0.21	Ncor2	nuclear receptor co-repressor 2	15735	0.2
chr2_180332745_180333375	0.21	Gata5os	GATA binding protein 5, opposite strand	203	0.89
chr5_43515484_43516406	0.20	C1qtnf7	C1q and tumor necrosis factor related protein 7	183	0.94
chr9_30921334_30922737	0.20	Adamts15	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15	417	0.86
chr5_24601266_24602082	0.20	Smarcd3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	226	0.86
chr5_129854658_129854926	0.20	Sumf2	sulfatase modifying factor 2	2281	0.16
chr9_56712934_56713139	0.20	Lingo1	leucine rich repeat and Ig domain containing 1	27783	0.18
chr10_103367601_103367825	0.20	Slc6a15	solute carrier family 6 (neurotransmitter transporter), member 15	70	0.98
chr14_51740214_51741404	0.20	Gm49261	predicted gene, 49261	296	0.81
chr3_128990459_128991248	0.20	Gm9387	predicted pseudogene 9387	35755	0.19
chr5_66746743_66746894	0.20	Limch1	LIM and calponin homology domains 1	929	0.55
chr6_88200114_88201718	0.20	Gata2	GATA binding protein 2	3	0.96
chr7_24499513_24500150	0.20	Cadm4	cell adhesion molecule 4	130	0.91
chr19_34253411_34255499	0.20	Acta2	actin, alpha 2, smooth muscle, aorta	225	0.92
chr13_32966469_32966620	0.20	Serpinb6b	serine (or cysteine) peptidase inhibitor, clade B, member 6b	1041	0.43
chr2_30469737_30470841	0.20	Ier5l	immediate early response 5-like	3930	0.16
chr4_155839735_155840422	0.20	Mxra8os	matrix-remodelling associated 8, opposite strand	100	0.67
chr2_67565793_67566876	0.19	B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	463	0.84
chr10_22158248_22159850	0.19	H60b	histocompatibility 60b	463	0.42
chr7_30291325_30291668	0.19	Clip3	CAP-GLY domain containing linker protein 3	232	0.8
chr7_112180336_112180681	0.19	Dkk3	dickkopf WNT signaling pathway inhibitor 3	21451	0.22
chr10_67939481_67939695	0.19	Zfp365	zinc finger protein 365	26926	0.16
chr14_105893244_105894185	0.19	Spry2	sprouty RTK signaling antagonist 2	3105	0.29
chr16_30540363_30541394	0.19	Tmem44	transmembrane protein 44	31	0.98
chr11_105293049_105293533	0.19	Mrc2	mannose receptor, C type 2	623	0.74
chr4_31823845_31825033	0.19	Map3k7	mitogen-activated protein kinase kinase kinase 7	139658	0.05
chr4_34436178_34436537	0.19	Gm12351	predicted gene 12351	21533	0.16
chr1_74090075_74091356	0.19	Tns1	tensin 1	636	0.71
chr7_18957439_18958650	0.19	Nanos2	nanos C2HC-type zinc finger 2	29356	0.06
chr15_76194294_76195998	0.19	Plec	plectin	564	0.56
chr4_42950234_42951162	0.19	Dnajb5	DnaJ heat shock protein family (Hsp40) member B5	258	0.87
chr6_128285700_128286493	0.19	Gm21893	predicted gene, 21893	8006	0.09
chr1_134801190_134801791	0.18	Gm37949	predicted gene, 37949	495	0.7
chr1_135793443_135794350	0.18	Tnni1	troponin I, skeletal, slow 1	5506	0.15
chr4_11705100_11705674	0.18	Gem	GTP binding protein (gene overexpressed in skeletal muscle)	420	0.85
chr12_71229100_71229280	0.18	Gm19045	predicted gene, 19045	23746	0.15
chr15_3581853_3582700	0.18	Ghr	growth hormone receptor	320	0.92
chr7_16581555_16581911	0.18	Gm29443	predicted gene 29443	32091	0.08
chr5_103426807_103426958	0.18	Ptpn13	protein tyrosine phosphatase, non-receptor type 13	1381	0.47
chr12_113185913_113186788	0.18	Tmem121	transmembrane protein 121	420	0.74
chr3_87172043_87172207	0.18	Kirrel	kirre like nephrin family adhesion molecule 1	2425	0.26
chr3_82073600_82074661	0.18	Gucy1b1	guanylate cyclase 1, soluble, beta 1	543	0.77
chr18_35034038_35034310	0.18	Gm36037	predicted gene, 36037	51204	0.09
chr17_46444584_46445824	0.18	Gm5093	predicted gene 5093	5107	0.11
chr11_72406421_72408105	0.18	Smtnl2	smoothelin-like 2	4155	0.15
chr15_61770777_61771058	0.18	D030024E09Rik	RIKEN cDNA D030024E09 gene	3534	0.33
chr7_3367594_3368044	0.18	Gm44257	predicted gene, 44257	22261	0.07
chr10_66901546_66901931	0.18	Gm47903	predicted gene, 47903	10126	0.15
chr2_113217092_113217461	0.18	Ryr3	ryanodine receptor 3	180	0.96
chrX_99044012_99044163	0.18	Stard8	START domain containing 8	103	0.97
chr9_119982824_119983895	0.18	1700019L13Rik	RIKEN cDNA 1700019L13 gene	80	0.79
chr17_71782384_71783600	0.18	Clip4	CAP-GLY domain containing linker protein family, member 4	375	0.84
chr6_47044703_47045103	0.18	Cntnap2	contactin associated protein-like 2	157	0.64
chr5_134746440_134747928	0.18	Eln	elastin	62	0.61
chr9_64014385_64014870	0.18	Smad6	SMAD family member 6	2360	0.24
chr7_101394207_101396000	0.18	Arap1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	448	0.73
chr4_97776884_97777081	0.17	Nfia	nuclear factor I/A	626	0.6
chr3_141491675_141491844	0.17	Unc5c	unc-5 netrin receptor C	26088	0.21
chr2_167542817_167543436	0.17	Snai1	snail family zinc finger 1	4931	0.13
chr9_48986724_48987891	0.17	Usp28	ubiquitin specific peptidase 28	1842	0.32
chr1_128592817_128593419	0.17	Cxcr4	chemokine (C-X-C motif) receptor 4	825	0.66
chr6_118479444_118479781	0.17	Zfp9	zinc finger protein 9	292	0.88
chr5_124529436_124529809	0.17	Gm43034	predicted gene 43034	1511	0.21
chr8_110805706_110805934	0.17	Il34	interleukin 34	52	0.67
chr18_37172243_37172684	0.17	Gm38097	predicted gene, 38097	101	0.95
chr9_71591283_71592381	0.17	Myzap	myocardial zonula adherens protein	433	0.84
chr11_105292145_105293042	0.17	Mrc2	mannose receptor, C type 2	50	0.98
chr10_76583951_76585206	0.17	Ftcd	formiminotransferase cyclodeaminase	2555	0.18
chr11_114479225_114479452	0.17	4932435O22Rik	RIKEN cDNA 4932435O22 gene	30478	0.2
chr13_48662866_48663051	0.17	Barx1	BarH-like homeobox 1	40	0.97
chr11_70232254_70232932	0.17	Mir497	microRNA 497	2124	0.1
chr2_74681727_74681878	0.17	Hoxd11	homeobox D11	521	0.45
chr14_51738531_51739887	0.17	Gm49261	predicted gene, 49261	1896	0.19
chr9_89497628_89497779	0.17	Gm47403	predicted gene, 47403	62681	0.11
chr4_48407474_48407947	0.17	Invs	inversin	25522	0.19
chr7_126248023_126249285	0.17	Sbk1	SH3-binding kinase 1	208	0.69
chr15_42962907_42963107	0.17	Rspo2	R-spondin 2	207811	0.02
chr13_31810556_31811961	0.17	Foxc1	forkhead box C1	4625	0.19
chr17_26847878_26848155	0.17	Nkx2-5	NK2 homeobox 5	3007	0.15
chr6_94281635_94282188	0.17	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	1114	0.58
chr1_193508615_193509882	0.17	Mir205hg	Mir205 host gene	926	0.47
chr6_112273463_112275203	0.16	Lmcd1	LIM and cysteine-rich domains 1	575	0.71
chr2_94263215_94263820	0.16	Mir670hg	MIR670 host gene (non-protein coding)	1091	0.4
chr7_100924536_100925334	0.16	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	7172	0.15
chr13_3709021_3709715	0.16	Gm47695	predicted gene, 47695	50457	0.09
chr10_75174015_75174616	0.16	Bcr	BCR activator of RhoGEF and GTPase	350	0.89
chr2_71367675_71367887	0.16	Slc25a12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	32	0.97
chr1_12691898_12692734	0.16	Sulf1	sulfatase 1	7	0.98
chr16_16217315_16217547	0.16	Pkp2	plakophilin 2	4113	0.23
chr2_35557994_35559313	0.16	Gm13446	predicted gene 13446	49	0.85
chr2_35621752_35623107	0.16	Dab2ip	disabled 2 interacting protein	269	0.93
chr7_104314930_104315471	0.16	Trim12a	tripartite motif-containing 12A	143	0.53
chr10_68282341_68283288	0.16	Arid5b	AT rich interactive domain 5B (MRF1-like)	4074	0.25
chr19_47313387_47314780	0.16	Sh3pxd2a	SH3 and PX domains 2A	668	0.69
chr7_104352827_104353391	0.16	Trim12c	tripartite motif-containing 12C	229	0.84
chr6_114918735_114919212	0.16	Vgll4	vestigial like family member 4	2843	0.31
chr7_45215829_45217292	0.16	Tead2	TEA domain family member 2	113	0.88
chr17_26451915_26452093	0.16	Gm50269	predicted gene, 50269	12153	0.13
chr15_85670939_85672357	0.16	Lncppara	long noncoding RNA near Ppara	18032	0.13
chr11_103096614_103097909	0.16	Plcd3	phospholipase C, delta 3	4330	0.13
chr9_77917044_77917252	0.16	Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	216	0.92
chr7_4520460_4522358	0.16	Tnni3	troponin I, cardiac 3	842	0.35
chr6_14902200_14902426	0.16	Foxp2	forkhead box P2	835	0.77
chr10_62338281_62338607	0.16	Hk1os	hexokinase 1, opposite strand	1812	0.27
chr2_153224755_153225797	0.16	Tspyl3	TSPY-like 3	165	0.93
chr5_142819565_142820054	0.16	Tnrc18	trinucleotide repeat containing 18	2147	0.28
chr5_91402281_91403314	0.16	Btc	betacellulin, epidermal growth factor family member	25	0.99
chr11_85833878_85836704	0.15	Tbx2	T-box 2	2740	0.17
chr4_148001445_148002010	0.15	Nppa	natriuretic peptide type A	1005	0.33
chr4_152096248_152097724	0.15	Plekhg5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	267	0.86
chr1_135788611_135788952	0.15	Tnni1	troponin I, skeletal, slow 1	5716	0.15
chr5_103693169_103693605	0.15	Aff1	AF4/FMR2 family, member 1	1013	0.5
chr7_75141792_75142655	0.15	Sv2b	synaptic vesicle glycoprotein 2 b	5503	0.3
chr7_19747051_19747276	0.15	Nectin2	nectin cell adhesion molecule 2	2370	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr0b1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.5	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.1	0.2	GO:0035993	deltoid tuberosity development(GO:0035993)
0.1	0.2	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.1	0.4	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.1	0.2	GO:0010725	regulation of primitive erythrocyte differentiation(GO:0010725)
0.1	0.3	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.1	0.2	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1	0.3	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1	0.3	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.1	0.2	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.1	0.2	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.1	0.2	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1	0.2	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.1	0.2	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1	0.2	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1	0.3	GO:2000618	regulation of histone H4-K16 acetylation(GO:2000618)
0.1	0.2	GO:0003164	His-Purkinje system development(GO:0003164)
0.1	0.2	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0072076	nephrogenic mesenchyme development(GO:0072076)
0.0	0.2	GO:0071692	protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.0	0.1	GO:0097168	mesenchymal stem cell proliferation(GO:0097168)
0.0	0.2	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.2	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.2	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.2	GO:0090274	positive regulation of somatostatin secretion(GO:0090274)
0.0	0.3	GO:0061577	calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577)
0.0	0.1	GO:0072092	ureteric bud invasion(GO:0072092)
0.0	0.0	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.2	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:1903797	positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0007223	Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.1	GO:0014738	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0	0.1	GO:1903261	regulation of serine phosphorylation of STAT3 protein(GO:1903261)
0.0	0.2	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.0	0.2	GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.0	0.2	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.1	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.1	GO:0051466	positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0072566	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.1	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.0	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:0052203	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.3	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.1	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.0	0.3	GO:2000010	positive regulation of protein localization to cell surface(GO:2000010)
0.0	0.1	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.2	GO:1904321	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0	0.1	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.1	GO:0035989	tendon development(GO:0035989)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0061314	Notch signaling involved in heart development(GO:0061314)
0.0	0.3	GO:0045475	locomotor rhythm(GO:0045475)
0.0	0.1	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.0	0.1	GO:0014827	intestine smooth muscle contraction(GO:0014827)
0.0	0.0	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.0	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.2	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0035701	hematopoietic stem cell migration(GO:0035701)
0.0	0.1	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.2	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.2	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0	0.1	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.0	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.1	GO:0036289	peptidyl-serine autophosphorylation(GO:0036289)
0.0	0.0	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.1	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.2	GO:0035810	positive regulation of urine volume(GO:0035810)
0.0	0.1	GO:0060837	blood vessel endothelial cell differentiation(GO:0060837)
0.0	0.1	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.1	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.0	0.1	GO:0014724	regulation of twitch skeletal muscle contraction(GO:0014724)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.1	GO:0032971	regulation of muscle filament sliding(GO:0032971)
0.0	0.1	GO:0035459	cargo loading into vesicle(GO:0035459)
0.0	0.1	GO:0060279	positive regulation of ovulation(GO:0060279)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.0	GO:0071500	cellular response to nitrosative stress(GO:0071500)
0.0	0.2	GO:0035330	regulation of hippo signaling(GO:0035330)
0.0	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.1	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.1	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.0	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0	0.1	GO:0002568	somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0	0.1	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0	0.1	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
0.0	0.0	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.0	GO:0048382	mesendoderm development(GO:0048382)
0.0	0.0	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0051795	positive regulation of catagen(GO:0051795)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0021747	cochlear nucleus development(GO:0021747)
0.0	0.1	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.2	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0	0.0	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.1	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.0	0.0	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:0018211	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.2	GO:0042481	regulation of odontogenesis(GO:0042481)
0.0	0.0	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.0	GO:1903423	positive regulation of synaptic vesicle recycling(GO:1903423)
0.0	0.1	GO:0060973	cell migration involved in heart development(GO:0060973)
0.0	0.1	GO:1903054	negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0	0.0	GO:0060221	retinal rod cell differentiation(GO:0060221)
0.0	0.0	GO:0008065	establishment of blood-nerve barrier(GO:0008065)
0.0	0.1	GO:0034351	negative regulation of glial cell apoptotic process(GO:0034351)
0.0	0.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.2	GO:0045838	positive regulation of membrane potential(GO:0045838)
0.0	0.0	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.2	GO:0097320	membrane tubulation(GO:0097320)
0.0	0.1	GO:0033623	regulation of integrin activation(GO:0033623)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0042659	regulation of cell fate specification(GO:0042659)
0.0	0.0	GO:0046909	intermembrane transport(GO:0046909)
0.0	0.1	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.0	0.1	GO:0060334	regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0071732	cellular response to nitric oxide(GO:0071732)
0.0	0.0	GO:1904528	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0071503	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.0	GO:0010749	regulation of nitric oxide mediated signal transduction(GO:0010749)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.1	GO:0051127	positive regulation of actin nucleation(GO:0051127)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.2	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0060283	negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0	0.0	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.0	GO:0036118	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.0	GO:1902414	protein localization to cell junction(GO:1902414)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.0	GO:0035624	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.0	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.2	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.2	GO:0001516	prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0	0.0	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.1	GO:0019732	antifungal humoral response(GO:0019732)
0.0	0.0	GO:0042525	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.1	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.4	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	0.0	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.3	GO:1990462	omegasome(GO:1990462)
0.0	0.1	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.2	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0071953	elastic fiber(GO:0071953)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.2	GO:0005861	troponin complex(GO:0005861)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.2	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.2	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0005859	muscle myosin complex(GO:0005859)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0044214	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0	0.1	GO:0002139	stereocilia coupling link(GO:0002139)
0.0	0.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.2	GO:0033643	host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.3	GO:0030057	desmosome(GO:0030057)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.6	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.2	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0097543	ciliary inversin compartment(GO:0097543)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0035939	microsatellite binding(GO:0035939)
0.1	0.3	GO:0019158	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1	0.2	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.2	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.1	0.2	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.1	0.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.1	0.2	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1	0.2	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
0.0	0.5	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.2	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.2	GO:0097001	ceramide binding(GO:0097001)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.2	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.0	0.1	GO:0052833	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:0018638	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.2	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.3	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.3	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0	0.2	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.4	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.2	GO:0042171	lysophosphatidic acid acyltransferase activity(GO:0042171)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.2	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.1	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0042284	sphingolipid delta-4 desaturase activity(GO:0042284)
0.0	0.3	GO:0030553	cGMP binding(GO:0030553)
0.0	0.3	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0048038	quinone binding(GO:0048038)
0.0	0.1	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.0	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.1	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.4	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.0	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.3	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.3	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.4	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.6	PID BMP PATHWAY	BMP receptor signaling
0.4	PID S1P S1P3 PATHWAY	S1P3 pathway
0.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.2	ST ADRENERGIC	Adrenergic Pathway
0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	ST G ALPHA S PATHWAY	G alpha s Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.3	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.3	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME SIGNALING BY NOTCH3	Genes involved in Signaling by NOTCH3
0.0	0.4	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.0	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha