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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Nr2e1

Z-value: 0.96

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Transcription factors associated with Nr2e1

Gene Symbol	Gene ID	Gene Info
Nr2e1 Ensembl NCBI MGI UniProt	ENSMUSG00000019803.5	nuclear receptor subfamily 2, group E, member 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr10_42572386_42573295	Nr2e1	4012	0.228965	-0.58	1.1e-06	Click!
chr10_42574651_42575179	Nr2e1	5430	0.209548	-0.52	2.1e-05	Click!
chr10_42580702_42581378	Nr2e1	266	0.910608	-0.48	1.3e-04	Click!
chr10_42581935_42584872	Nr2e1	229	0.693617	-0.44	4.4e-04	Click!
chr10_42571122_42571273	Nr2e1	2369	0.295581	0.40	1.4e-03	Click!

Activity of the Nr2e1 motif across conditions

Conditions sorted by the z-value of the Nr2e1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_102900270_102900421	3.81	Cd44	CD44 antigen	1001	0.55
chr8_36951282_36952693	3.41	Dlc1	deleted in liver cancer 1	370	0.88
chr2_14823792_14824714	3.23	Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	161	0.94
chr8_122697547_122698708	3.21	Gm10612	predicted gene 10612	267	0.75
chr4_135727528_135728972	2.86	Il22ra1	interleukin 22 receptor, alpha 1	78	0.96
chr3_79887847_79889192	2.86	Gm36569	predicted gene, 36569	1713	0.31
chr8_28594238_28594908	2.60	Gm26795	predicted gene, 26795	1041	0.64
chr6_135362982_135365483	2.50	Emp1	epithelial membrane protein 1	1164	0.42
chr18_54423477_54423649	2.46	Redrum	Redrum, erythroid developmental long intergenic non-protein coding transcript	1268	0.55
chr10_21996845_21998265	2.40	Sgk1	serum/glucocorticoid regulated kinase 1	964	0.51
chr19_6968781_6970375	2.27	Plcb3	phospholipase C, beta 3	130	0.89
chr6_122391330_122392825	2.26	1700063H04Rik	RIKEN cDNA 1700063H04 gene	698	0.58
chr13_49545394_49545652	2.23	Aspn	asporin	1036	0.47
chr14_46385551_46387400	2.02	Bmp4	bone morphogenetic protein 4	829	0.41
chr8_104629629_104629943	1.99	Gm33023	predicted gene, 33023	1046	0.27
chr7_19796098_19797425	1.95	Cblc	Casitas B-lineage lymphoma c	32	0.93
chr11_6695084_6695634	1.95	Gm11980	predicted gene 11980	9535	0.1
chr1_139459017_139459540	1.90	Aspm	abnormal spindle microtubule assembly	4459	0.2
chr14_75136350_75137361	1.88	Gm15628	predicted gene 15628	57	0.84
chr14_65374778_65375936	1.85	Zfp395	zinc finger protein 395	36	0.97
chr18_62174392_62175675	1.75	Adrb2	adrenergic receptor, beta 2	4926	0.21
chr14_59478693_59479244	1.75	Cab39l	calcium binding protein 39-like	152	0.96
chr19_36734732_36735279	1.75	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	1648	0.41
chr9_118609328_118610280	1.70	Itga9	integrin alpha 9	3114	0.22
chr17_87458960_87459465	1.69	Gm30794	predicted gene, 30794	215	0.89
chr7_97749255_97749938	1.67	Aqp11	aquaporin 11	11307	0.16
chr1_58803130_58803704	1.64	Casp8	caspase 8	764	0.57
chr5_107723149_107724482	1.60	Gfi1	growth factor independent 1 transcription repressor	528	0.61
chr9_21225794_21226024	1.59	Gm16754	predicted gene, 16754	506	0.62
chr10_62333211_62333603	1.58	Hk1	hexokinase 1	5640	0.18
chr13_46422196_46422985	1.54	Rbm24	RNA binding motif protein 24	768	0.72
chr16_14708705_14709220	1.51	Snai2	snail family zinc finger 2	3110	0.32
chr2_84938213_84938457	1.50	Slc43a3	solute carrier family 43, member 3	1445	0.3
chr13_63273798_63275383	1.49	Gm47585	predicted gene, 47585	990	0.28
chr6_98105417_98106059	1.48	Gm32592	predicted gene, 32592	16058	0.28
chr1_65112211_65113305	1.45	Gm28845	predicted gene 28845	6800	0.1
chr5_112894973_112895548	1.44	Myo18b	myosin XVIIIb	1102	0.54
chr11_116621806_116622164	1.44	Rhbdf2	rhomboid 5 homolog 2	2215	0.16
chrX_8271051_8272966	1.43	Slc38a5	solute carrier family 38, member 5	366	0.82
chr11_120041112_120041753	1.35	Aatk	apoptosis-associated tyrosine kinase	350	0.76
chr18_32020056_32020475	1.35	Gm16344	predicted gene 16344	1475	0.3
chr5_119832754_119833593	1.33	Tbx5	T-box 5	505	0.67
chr18_24207578_24207957	1.32	Galnt1	polypeptide N-acetylgalactosaminyltransferase 1	1808	0.4
chr11_85831867_85832577	1.29	2610027K06Rik	RIKEN cDNA 2610027K06 gene	1	0.83
chr4_106804374_106805428	1.28	Acot11	acyl-CoA thioesterase 11	97	0.96
chr18_38928285_38929463	1.27	Fgf1	fibroblast growth factor 1	283	0.92
chr1_152613508_152613830	1.27	Rgl1	ral guanine nucleotide dissociation stimulator,-like 1	11360	0.23
chr3_30010716_30011762	1.26	Mecom	MDS1 and EVI1 complex locus	200	0.91
chr10_76621571_76623890	1.26	Col6a2	collagen, type VI, alpha 2	595	0.68
chr3_152186163_152186981	1.25	Dnajb4	DnaJ heat shock protein family (Hsp40) member B4	7273	0.12
chr9_32542191_32543480	1.24	Fli1	Friend leukemia integration 1	26	0.96
chr1_189340106_189340450	1.23	Kcnk2	potassium channel, subfamily K, member 2	3077	0.24
chr1_173765275_173765426	1.23	Ifi204	interferon activated gene 204	1569	0.29
chr6_5291634_5291917	1.23	Pon2	paraoxonase 2	2707	0.25
chr7_80340748_80340916	1.22	Unc45a	unc-45 myosin chaperone A	613	0.53
chr11_19924464_19925719	1.21	Spred2	sprouty-related EVH1 domain containing 2	649	0.8
chr2_164430518_164431363	1.19	Sdc4	syndecan 4	12246	0.08
chr16_85799431_85799812	1.19	Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	17	0.98
chr4_156057052_156057354	1.16	Mir200b	microRNA 200b	1453	0.16
chr13_4233789_4234486	1.14	Akr1c19	aldo-keto reductase family 1, member C19	397	0.81
chr16_95456632_95459094	1.14	Erg	ETS transcription factor	1382	0.55
chr1_53784204_53785301	1.12	Stk17b	serine/threonine kinase 17b (apoptosis-inducing)	405	0.84
chr5_96459926_96460182	1.11	Gm33050	predicted gene, 33050	2311	0.35
chr3_14641184_14642360	1.11	Car13	carbonic anhydrase 13	45	0.97
chr4_107367758_107368908	1.11	Ndc1	NDC1 transmembrane nucleoporin	281	0.87
chr15_99847922_99848073	1.11	Lima1	LIM domain and actin binding 1	26674	0.07
chr13_4771096_4771932	1.09	Gm5444	predicted gene 5444	137	0.97
chr8_107545084_107547731	1.08	Wwp2	WW domain containing E3 ubiquitin protein ligase 2	1395	0.4
chr10_18430762_18431621	1.08	Nhsl1	NHS-like 1	23516	0.21
chr7_49558634_49559566	1.08	Nav2	neuron navigator 2	5208	0.29
chr8_33884869_33886307	1.07	Gm26978	predicted gene, 26978	159	0.95
chr3_159495460_159496348	1.06	Depdc1a	DEP domain containing 1a	446	0.86
chr6_92922108_92922259	1.05	9530026P05Rik	RIKEN cDNA 9530026P05 gene	18146	0.19
chr1_171370056_171370775	1.03	Nectin4	nectin cell adhesion molecule 4	60	0.92
chr9_32697004_32697902	1.02	Ets1	E26 avian leukemia oncogene 1, 5' domain	1069	0.51
chr15_76118017_76119354	1.01	Eppk1	epiplakin 1	1510	0.2
chr11_97439854_97442222	1.01	Arhgap23	Rho GTPase activating protein 23	4753	0.18
chr6_5255342_5256653	0.99	Pon3	paraoxonase 3	217	0.93
chr11_59222811_59222962	0.99	Arf1	ADP-ribosylation factor 1	5276	0.1
chr9_44707957_44709119	0.98	Phldb1	pleckstrin homology like domain, family B, member 1	111	0.91
chr11_115832199_115833263	0.95	Llgl2	LLGL2 scribble cell polarity complex component	763	0.46
chr15_78802072_78803397	0.94	Card10	caspase recruitment domain family, member 10	65	0.95
chr1_91006722_91007010	0.93	Lrrfip1	leucine rich repeat (in FLII) interacting protein 1	8087	0.17
chr11_86586191_86587628	0.92	Vmp1	vacuole membrane protein 1	28	0.97
chr7_16892974_16894675	0.92	Gng8	guanine nucleotide binding protein (G protein), gamma 8	823	0.38
chr13_23684833_23685979	0.89	H2bc4	H2B clustered histone 4	1207	0.15
chr19_36117188_36117519	0.88	Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	2557	0.28
chr6_113611948_113612250	0.88	Gm44199	predicted gene, 44199	346	0.7
chr6_23034724_23034980	0.88	Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	13420	0.23
chr2_164437671_164438167	0.88	Sdc4	syndecan 4	5267	0.09
chr3_142935794_142936139	0.88	Gm2574	predicted pseudogene 2574	26645	0.13
chr2_128393535_128393789	0.88	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	9303	0.2
chr14_19839499_19840279	0.88	D14Ertd670e	DNA segment, Chr 14, ERATO Doi 670, expressed	964	0.5
chr12_59095360_59096062	0.88	Mia2	MIA SH3 domain ER export factor 2	88	0.93
chr10_41518008_41518159	0.88	Cd164	CD164 antigen	1331	0.31
chr14_63231019_63231782	0.87	Gata4	GATA binding protein 4	13848	0.16
chr3_100485235_100486511	0.87	Tent5c	terminal nucleotidyltransferase 5C	3321	0.18
chr6_50984587_50985154	0.87	Gm44402	predicted gene, 44402	17602	0.22
chr9_62420746_62421699	0.87	Coro2b	coronin, actin binding protein, 2B	6779	0.24
chr16_87796555_87796975	0.86	2810407A14Rik	RIKEN cDNA 2810407A14 gene	9193	0.23
chr6_38346540_38346956	0.86	Zc3hav1	zinc finger CCCH type, antiviral 1	7525	0.13
chr8_126943617_126943858	0.85	Gm26397	predicted gene, 26397	1243	0.36
chr12_107930390_107931544	0.84	Bcl11b	B cell leukemia/lymphoma 11B	72447	0.11
chr3_95517184_95517335	0.83	Ctss	cathepsin S	9527	0.1
chr13_97777725_97778158	0.83	Gm47577	predicted gene, 47577	12623	0.14
chr18_69428277_69428540	0.83	Tcf4	transcription factor 4	12511	0.28
chr1_71649541_71649936	0.83	Apol7d	apolipoprotein L 7d	3099	0.23
chr1_117627739_117627890	0.83	Zfp813-ps	zinc finger protein 813, pseudogene	2292	0.27
chr13_62939321_62939472	0.83	Gm48812	predicted gene, 48812	10046	0.15
chr5_119673827_119675890	0.82	Tbx3	T-box 3	587	0.67
chr7_131542096_131543636	0.82	Hmx3	H6 homeobox 3	1	0.97
chr8_105824560_105824761	0.82	Ranbp10	RAN binding protein 10	2545	0.13
chr8_33931058_33931981	0.81	Rbpms	RNA binding protein gene with multiple splicing	1656	0.35
chr18_11634022_11634727	0.80	Rbbp8	retinoblastoma binding protein 8, endonuclease	1003	0.55
chr11_109705936_109706264	0.80	Fam20a	family with sequence similarity 20, member A	16156	0.17
chr3_96459534_96459685	0.80	Rnu1b6	U1b6 small nuclear RNA	580	0.4
chr3_96427092_96427805	0.79	Gm24136	predicted gene, 24136	4715	0.06
chr4_156252393_156253403	0.79	Samd11	sterile alpha motif domain containing 11	503	0.6
chr17_28694283_28694478	0.79	Mapk14	mitogen-activated protein kinase 14	1812	0.24
chr9_103229120_103230944	0.78	Trf	transferrin	234	0.92
chr10_86302733_86303435	0.78	Timp3	tissue inhibitor of metalloproteinase 3	230	0.95
chr4_138367166_138368455	0.78	Cda	cytidine deaminase	182	0.91
chr17_81538671_81538827	0.77	Gm11096	predicted gene 11096	96986	0.08
chr3_118594825_118595034	0.77	Dpyd	dihydropyrimidine dehydrogenase	32743	0.16
chr1_40431747_40431974	0.77	Il1rl1	interleukin 1 receptor-like 1	2290	0.31
chr4_57559942_57560175	0.77	Pakap	paralemmin A kinase anchor protein	8101	0.27
chr14_65666400_65667092	0.76	Scara5	scavenger receptor class A, member 5	309	0.92
chr5_66080287_66081072	0.76	Rbm47	RNA binding motif protein 47	305	0.84
chr7_108929500_108930178	0.76	Nlrp10	NLR family, pyrin domain containing 10	339	0.81
chr2_163285470_163285918	0.76	Tox2	TOX high mobility group box family member 2	34684	0.16
chr16_31878792_31879568	0.76	Meltf	melanotransferrin	370	0.79
chr6_119139273_119139837	0.75	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	30982	0.19
chr17_12879713_12880397	0.75	Mrgprh	MAS-related GPR, member H	4021	0.09
chr9_60562470_60563218	0.74	Gm17853	predicted gene, 17853	14649	0.13
chr8_47763533_47764764	0.74	Gm45824	predicted gene 45824	1977	0.21
chr1_93341815_93342084	0.74	Pask	PAS domain containing serine/threonine kinase	840	0.3
chr6_38096458_38097053	0.74	Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	430	0.81
chr1_64288992_64289511	0.73	Gm28981	predicted gene 28981	13792	0.25
chr13_38145014_38146012	0.73	Dsp	desmoplakin	5781	0.18
chr3_96450951_96451691	0.73	Gm26232	predicted gene, 26232	875	0.23
chr7_65881133_65881882	0.73	Pcsk6	proprotein convertase subtilisin/kexin type 6	19075	0.17
chr8_70617458_70618772	0.73	Lrrc25	leucine rich repeat containing 25	1271	0.24
chr15_37232146_37233490	0.72	Grhl2	grainyhead like transcription factor 2	218	0.61
chr6_113073767_113073990	0.71	Gt(ROSA)26Sor	gene trap ROSA 26, Philippe Soriano	3299	0.14
chr9_48338929_48340200	0.71	Nxpe2	neurexophilin and PC-esterase domain family, member 2	1270	0.48
chr3_144759885_144761021	0.70	Clca3a1	chloride channel accessory 3A1	388	0.78
chr7_127992791_127993997	0.70	Gm45205	predicted gene 45205	125	0.49
chr1_161130373_161131460	0.70	Klhl20	kelch-like 20	512	0.64
chr4_48471212_48471758	0.69	Tex10	testis expressed gene 10	1489	0.48
chr10_99171911_99172473	0.69	Poc1b	POC1 centriolar protein B	908	0.48
chr5_75152837_75154692	0.69	Gm42802	predicted gene 42802	111	0.58
chr3_116436866_116437065	0.69	Cdc14a	CDC14 cell division cycle 14A	8220	0.14
chr19_38071837_38072155	0.67	Gm23300	predicted gene, 23300	67	0.96
chr15_8967409_8968940	0.67	Ranbp3l	RAN binding protein 3-like	172	0.96
chr8_23035959_23037041	0.67	Ank1	ankyrin 1, erythroid	1269	0.45
chr6_42583431_42583615	0.66	Tcaf3	TRPM8 channel-associated factor 3	4106	0.17
chr12_84053031_84054350	0.65	4732463B04Rik	RIKEN cDNA 4732463B04 gene	117	0.84
chr3_14891263_14891907	0.65	Car2	carbonic anhydrase 2	4946	0.21
chr10_108595779_108596540	0.65	Syt1	synaptotagmin I	40805	0.18
chr3_129329164_129329956	0.65	Enpep	glutamyl aminopeptidase	2704	0.24
chr12_58265531_58265740	0.64	Clec14a	C-type lectin domain family 14, member a	3655	0.34
chr19_43711302_43711596	0.64	Entpd7	ectonucleoside triphosphate diphosphohydrolase 7	37	0.96
chr6_125565161_125565421	0.63	Vwf	Von Willebrand factor	960	0.59
chr4_6446904_6447515	0.63	Nsmaf	neutral sphingomyelinase (N-SMase) activation associated factor	882	0.63
chr1_165709053_165709299	0.63	Rcsd1	RCSD domain containing 1	217	0.88
chr1_105784380_105784829	0.63	Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	3854	0.21
chr2_170132843_170133989	0.63	Zfp217	zinc finger protein 217	529	0.86
chr6_71106178_71106774	0.62	Gm43906	predicted gene, 43906	35	0.97
chr11_107471149_107471443	0.62	Pitpnc1	phosphatidylinositol transfer protein, cytoplasmic 1	597	0.63
chr15_6582470_6582801	0.62	Fyb	FYN binding protein	2367	0.32
chr16_44018376_44019228	0.62	Gramd1c	GRAM domain containing 1C	2366	0.26
chr13_100726235_100726386	0.62	Cdk7	cyclin-dependent kinase 7	4590	0.14
chr5_5708100_5708698	0.62	Gm43219	predicted gene 43219	11541	0.15
chr12_33960516_33961726	0.62	Twist1	twist basic helix-loop-helix transcription factor 1	3450	0.27
chr11_18900578_18900927	0.61	2900018N21Rik	RIKEN cDNA 2900018N21 gene	10912	0.16
chr15_9472649_9473025	0.61	Gm50456	predicted gene, 50456	2665	0.3
chr8_61359671_61360071	0.61	Sh3rf1	SH3 domain containing ring finger 1	1718	0.33
chrX_101132557_101132904	0.61	Gm24061	predicted gene, 24061	8822	0.15
chrX_153723168_153724170	0.61	Nbdy	negative regulator of P-body association	42	0.72
chr2_9888877_9890320	0.61	9230102O04Rik	RIKEN cDNA 9230102O04 gene	58	0.84
chr1_181334992_181336043	0.60	Cnih3	cornichon family AMPA receptor auxiliary protein 3	17111	0.15
chr4_63401307_63401719	0.60	Akna	AT-hook transcription factor	1841	0.25
chr19_48399865_48400528	0.60	Sorcs3	sortilin-related VPS10 domain containing receptor 3	29764	0.25
chr7_98537565_98537716	0.60	A630091E08Rik	RIKEN cDNA A630091E08 gene	25350	0.12
chr2_73970694_73971332	0.60	Gm13668	predicted gene 13668	10344	0.22
chr14_120832047_120832808	0.59	Gm9391	predicted gene 9391	5269	0.18
chr19_25575234_25575953	0.59	Dmrt3	doublesex and mab-3 related transcription factor 3	34708	0.16
chr10_39612918_39613668	0.59	Traf3ip2	TRAF3 interacting protein 2	359	0.48
chr1_87573319_87573846	0.59	Ngef	neuronal guanine nucleotide exchange factor	288	0.62
chr2_58160498_58161190	0.58	Cytip	cytohesin 1 interacting protein	187	0.94
chr10_61413178_61413819	0.58	Nodal	nodal	4474	0.13
chr11_110551465_110551828	0.58	Gm11682	predicted gene 11682	7139	0.3
chr6_83068298_83071797	0.58	Tlx2	T cell leukemia, homeobox 2	178	0.81
chr18_67243425_67244046	0.58	Mppe1	metallophosphoesterase 1	1542	0.33
chr5_75835291_75836239	0.58	Gm19590	predicted gene, 19590	120	0.96
chr3_103860271_103860967	0.58	Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	64	0.93
chrX_47880010_47880161	0.57	Smarca1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	12311	0.19
chr17_75435976_75437284	0.57	Rasgrp3	RAS, guanyl releasing protein 3	704	0.77
chr2_120630360_120631203	0.57	Stard9	START domain containing 9	1655	0.28
chr14_21849942_21850976	0.57	Comtd1	catechol-O-methyltransferase domain containing 1	1482	0.27

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	3.0	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.7	2.1	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.5	1.4	GO:0010159	specification of organ position(GO:0010159)
0.4	1.2	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.4	1.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.4	1.1	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.3	1.4	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.3	1.0	GO:0003166	bundle of His development(GO:0003166)
0.2	0.7	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2	0.5	GO:0010957	negative regulation of vitamin D biosynthetic process(GO:0010957)
0.2	1.0	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.2	0.7	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.2	1.2	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.2	0.7	GO:0016554	cytidine to uridine editing(GO:0016554)
0.2	1.3	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.2	3.1	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.2	1.0	GO:0032482	Rab protein signal transduction(GO:0032482)
0.2	1.8	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2	0.8	GO:0097460	ferrous iron import into cell(GO:0097460)
0.2	0.9	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.2	0.5	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.2	0.7	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.2	0.5	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.2	0.8	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636)
0.2	0.8	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1	0.4	GO:0060671	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1	0.6	GO:0090306	spindle assembly involved in meiosis(GO:0090306)
0.1	0.6	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.1	0.4	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1	0.4	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.1	0.4	GO:0021564	vagus nerve development(GO:0021564)
0.1	1.2	GO:0015816	glycine transport(GO:0015816)
0.1	1.5	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.1	0.7	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1	0.3	GO:1901535	regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.1	0.5	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1	0.2	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1	0.4	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.1	1.3	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1	0.5	GO:0030578	PML body organization(GO:0030578)
0.1	0.3	GO:0002277	myeloid dendritic cell activation involved in immune response(GO:0002277)
0.1	0.2	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.1	0.6	GO:2000318	positive regulation of T-helper 17 type immune response(GO:2000318)
0.1	0.3	GO:0072276	glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1	0.8	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.1	1.4	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	1.7	GO:0035855	megakaryocyte development(GO:0035855)
0.1	1.0	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.1	1.1	GO:0032060	bleb assembly(GO:0032060)
0.1	0.2	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1	0.3	GO:1903232	melanosome assembly(GO:1903232)
0.1	0.4	GO:0051031	tRNA transport(GO:0051031)
0.1	0.3	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.2	GO:1900238	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.1	0.2	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.1	0.2	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.1	3.1	GO:0050829	defense response to Gram-negative bacterium(GO:0050829)
0.1	0.3	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.1	0.5	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.1	0.2	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.1	0.2	GO:0090400	stress-induced premature senescence(GO:0090400)
0.1	0.2	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1	0.3	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.1	0.2	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.1	0.1	GO:0003164	His-Purkinje system development(GO:0003164)
0.1	0.8	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.1	0.2	GO:0003175	tricuspid valve development(GO:0003175)
0.1	0.3	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.1	0.4	GO:0000022	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1	0.3	GO:0070836	caveola assembly(GO:0070836)
0.1	2.2	GO:0009395	phospholipid catabolic process(GO:0009395)
0.1	0.2	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.1	0.3	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1	0.4	GO:0008063	Toll signaling pathway(GO:0008063)
0.1	0.3	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.1	0.3	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
0.1	0.2	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.1	0.2	GO:0035672	oligopeptide transmembrane transport(GO:0035672)
0.1	0.2	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.1	0.1	GO:1902302	regulation of potassium ion export(GO:1902302)
0.1	0.3	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.1	0.2	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1	0.2	GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003256)
0.1	0.5	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1	0.2	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.1	0.1	GO:0061438	renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439)
0.1	0.2	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.1	0.2	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.1	0.1	GO:0032532	regulation of microvillus length(GO:0032532)
0.1	0.2	GO:0070842	aggresome assembly(GO:0070842)
0.1	0.3	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.1	0.2	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.1	0.1	GO:0014900	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1	0.8	GO:0006895	Golgi to endosome transport(GO:0006895)
0.1	1.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.1	0.4	GO:1903715	regulation of aerobic respiration(GO:1903715)
0.0	0.0	GO:0086064	cell communication by electrical coupling involved in cardiac conduction(GO:0086064)
0.0	0.0	GO:0035907	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0	0.2	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.2	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.2	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.3	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:0060931	sinoatrial node cell development(GO:0060931)
0.0	0.3	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0034035	purine ribonucleoside bisphosphate metabolic process(GO:0034035)
0.0	0.2	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.1	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.3	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.0	0.0	GO:0032077	positive regulation of deoxyribonuclease activity(GO:0032077)
0.0	0.1	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.2	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	0.2	GO:0032196	transposition(GO:0032196)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.2	GO:2000065	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.2	GO:0097461	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.1	GO:1901382	chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0	0.7	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.1	GO:0086103	G-protein coupled receptor signaling pathway involved in heart process(GO:0086103)
0.0	0.1	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0	1.3	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.1	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.1	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.0	0.2	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.0	0.2	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.1	GO:0010963	regulation of amino acid import(GO:0010958) regulation of L-arginine import(GO:0010963)
0.0	0.1	GO:0015684	ferrous iron transport(GO:0015684)
0.0	0.5	GO:0048484	enteric nervous system development(GO:0048484)
0.0	0.1	GO:0032290	peripheral nervous system myelin formation(GO:0032290)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.3	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0	0.2	GO:0072488	nitrogen utilization(GO:0019740) ammonium transmembrane transport(GO:0072488)
0.0	0.2	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.8	GO:0070328	acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0014707	branchiomeric skeletal muscle development(GO:0014707)
0.0	0.3	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.2	GO:1903779	regulation of cardiac conduction(GO:1903779)
0.0	0.2	GO:2000394	positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0	0.4	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0097212	lysosomal membrane organization(GO:0097212)
0.0	0.1	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0	0.4	GO:0097354	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.1	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.0	GO:0016078	tRNA catabolic process(GO:0016078)
0.0	0.5	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.3	GO:0032754	positive regulation of interleukin-5 production(GO:0032754)
0.0	0.0	GO:0045423	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.2	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.1	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.1	GO:0070827	chromatin maintenance(GO:0070827)
0.0	0.2	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.1	GO:0010002	cardioblast differentiation(GO:0010002)
0.0	0.0	GO:0048382	mesendoderm development(GO:0048382)
0.0	0.1	GO:0002254	kinin cascade(GO:0002254)
0.0	0.1	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.1	GO:0071351	cellular response to interleukin-18(GO:0071351)
0.0	0.1	GO:0002215	defense response to nematode(GO:0002215)
0.0	0.6	GO:0048821	erythrocyte development(GO:0048821)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.3	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	1.4	GO:0007566	embryo implantation(GO:0007566)
0.0	0.2	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0046865	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0	0.2	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0	0.1	GO:0032847	regulation of cellular pH reduction(GO:0032847) positive regulation of cellular pH reduction(GO:0032849)
0.0	0.1	GO:1904261	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.3	GO:0043584	nose development(GO:0043584)
0.0	0.0	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.0	0.1	GO:0015809	arginine transport(GO:0015809)
0.0	0.6	GO:0009813	flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0061055	myotome development(GO:0061055)
0.0	0.1	GO:0052055	modulation by symbiont of host molecular function(GO:0052055)
0.0	0.1	GO:1904995	negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0	0.1	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.0	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	1.1	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.7	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.3	GO:0051601	exocyst localization(GO:0051601)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.1	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.0	0.1	GO:1904970	brush border assembly(GO:1904970)
0.0	0.1	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.2	GO:0034472	snRNA 3'-end processing(GO:0034472)
0.0	0.1	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0032788	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:0019249	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.0	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.1	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.1	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	0.1	GO:1903960	negative regulation of anion channel activity(GO:0010360) negative regulation of anion transmembrane transport(GO:1903960)
0.0	0.1	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.2	GO:0034383	low-density lipoprotein particle clearance(GO:0034383)
0.0	0.1	GO:0071692	protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.0	0.2	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.0	GO:0030913	paranodal junction assembly(GO:0030913)
0.0	0.3	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.0	GO:0045914	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:0010626	negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.1	GO:0010917	negative regulation of mitochondrial membrane potential(GO:0010917)
0.0	0.1	GO:1902414	protein localization to cell junction(GO:1902414)
0.0	0.0	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.2	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.0	GO:0021563	glossopharyngeal nerve development(GO:0021563)
0.0	0.1	GO:2001260	regulation of semaphorin-plexin signaling pathway(GO:2001260)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.7	GO:1901016	regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.0	0.2	GO:1900452	regulation of long term synaptic depression(GO:1900452)
0.0	0.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.3	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.8	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.2	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396) tetrahydrofolate biosynthetic process(GO:0046654)
0.0	0.6	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0	0.1	GO:0061643	chemorepulsion of axon(GO:0061643)
0.0	0.1	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.1	GO:0001951	intestinal D-glucose absorption(GO:0001951)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.3	GO:0048305	immunoglobulin secretion(GO:0048305)
0.0	0.3	GO:0021889	olfactory bulb interneuron differentiation(GO:0021889)
0.0	0.3	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.0	GO:0072198	mesenchymal cell proliferation involved in ureter development(GO:0072198) regulation of mesenchymal cell proliferation involved in ureter development(GO:0072199)
0.0	0.1	GO:0040031	snRNA modification(GO:0040031)
0.0	0.0	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.0	0.5	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.2	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.0	GO:0035927	RNA import into mitochondrion(GO:0035927)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.1	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0	0.1	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.0	0.5	GO:0033120	positive regulation of RNA splicing(GO:0033120)
0.0	0.0	GO:1905048	regulation of metallopeptidase activity(GO:1905048)
0.0	0.0	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.1	GO:0032252	secretory granule localization(GO:0032252)
0.0	0.2	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.3	GO:0097150	neuronal stem cell population maintenance(GO:0097150)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:0042481	regulation of odontogenesis(GO:0042481)
0.0	0.0	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.0	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0	0.7	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	0.0	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.0	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.0	0.1	GO:0070166	enamel mineralization(GO:0070166)
0.0	0.0	GO:0097459	iron ion import into cell(GO:0097459)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.2	GO:0042036	negative regulation of cytokine biosynthetic process(GO:0042036)
0.0	0.1	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:1902570	protein localization to nucleolus(GO:1902570)
0.0	0.1	GO:0033234	negative regulation of protein sumoylation(GO:0033234)
0.0	0.0	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.0	GO:0061325	cell proliferation involved in outflow tract morphogenesis(GO:0061325)
0.0	0.1	GO:0034116	positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.0	0.0	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.0	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.1	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.0	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0071711	basement membrane organization(GO:0071711)
0.0	0.1	GO:0008594	photoreceptor cell morphogenesis(GO:0008594)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:0032570	response to progesterone(GO:0032570)
0.0	0.0	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.0	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.4	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.0	0.3	GO:0033198	response to ATP(GO:0033198)
0.0	0.1	GO:0043206	extracellular fibril organization(GO:0043206)
0.0	0.0	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0097503	sialylation(GO:0097503)
0.0	0.0	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.5	GO:0007569	cell aging(GO:0007569)
0.0	0.1	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.0	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:1904861	excitatory synapse assembly(GO:1904861)
0.0	0.1	GO:0097501	stress response to metal ion(GO:0097501)
0.0	0.1	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0	0.1	GO:0060416	response to growth hormone(GO:0060416)
0.0	0.2	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.1	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.2	GO:0006884	cell volume homeostasis(GO:0006884)
0.0	0.0	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0	0.1	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.0	0.0	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0046886	positive regulation of hormone biosynthetic process(GO:0046886)
0.0	0.0	GO:0072530	purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642)
0.0	0.0	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0001915	negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.0	GO:0090258	negative regulation of mitochondrial fission(GO:0090258)
0.0	0.1	GO:0006548	histidine metabolic process(GO:0006547) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.0	GO:2000973	regulation of pro-B cell differentiation(GO:2000973)
0.0	0.2	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.0	GO:0003383	apical constriction(GO:0003383)
0.0	0.0	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:0042635	positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0	0.0	GO:0051697	protein delipidation(GO:0051697)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.0	0.0	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.0	GO:0061589	calcium activated phosphatidylserine scrambling(GO:0061589)
0.0	0.0	GO:0045628	regulation of T-helper 2 cell differentiation(GO:0045628)
0.0	0.0	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.0	GO:0044351	macropinocytosis(GO:0044351)
0.0	0.0	GO:2000409	positive regulation of T cell extravasation(GO:2000409)
0.0	0.0	GO:0086018	SA node cell action potential(GO:0086015) SA node cell to atrial cardiac muscle cell signalling(GO:0086018) SA node cell to atrial cardiac muscle cell communication(GO:0086070)
0.0	0.1	GO:0070255	regulation of mucus secretion(GO:0070255)
0.0	0.0	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.0	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0	0.0	GO:1902510	regulation of apoptotic DNA fragmentation(GO:1902510)
0.0	0.0	GO:0015671	oxygen transport(GO:0015671)
0.0	0.0	GO:0032906	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0	0.1	GO:0006103	2-oxoglutarate metabolic process(GO:0006103)
0.0	0.0	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.0	GO:0010579	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.0	0.0	GO:0035822	meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)
0.0	0.0	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.1	GO:0006348	chromatin silencing at telomere(GO:0006348)
0.0	0.0	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.0	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.3	GO:1901184	regulation of ERBB signaling pathway(GO:1901184)
0.0	0.1	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.2	1.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.2	0.8	GO:0016461	unconventional myosin complex(GO:0016461)
0.2	0.8	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.1	0.7	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1	0.4	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.1	0.4	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1	0.3	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.1	0.3	GO:0097149	centralspindlin complex(GO:0097149)
0.1	0.6	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	0.7	GO:0042587	glycogen granule(GO:0042587)
0.1	0.4	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	0.3	GO:0097452	GAIT complex(GO:0097452)
0.1	1.0	GO:0000421	autophagosome membrane(GO:0000421)
0.1	3.6	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	0.2	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	0.3	GO:0071547	piP-body(GO:0071547)
0.1	0.8	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.1	0.4	GO:0008385	IkappaB kinase complex(GO:0008385)
0.1	0.2	GO:0032437	cuticular plate(GO:0032437)
0.1	0.5	GO:0072687	meiotic spindle(GO:0072687)
0.0	0.4	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.2	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.0	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.4	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0035363	histone locus body(GO:0035363)
0.0	0.2	GO:0000796	condensin complex(GO:0000796)
0.0	1.1	GO:0016235	aggresome(GO:0016235)
0.0	0.2	GO:0098642	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	2.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.6	GO:0005922	connexon complex(GO:0005922)
0.0	0.9	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.5	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.3	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.3	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.2	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0000835	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.3	GO:0032039	integrator complex(GO:0032039)
0.0	0.1	GO:0005914	spot adherens junction(GO:0005914)
0.0	0.2	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.5	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	0.2	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.2	GO:0005655	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.2	GO:0042641	actomyosin(GO:0042641)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	1.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.5	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	1.6	GO:0005604	basement membrane(GO:0005604)
0.0	0.3	GO:0000145	exocyst(GO:0000145)
0.0	0.0	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.3	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0	0.1	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.0	0.2	GO:0097449	astrocyte projection(GO:0097449)
0.0	0.0	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.3	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.0	1.1	GO:0005643	nuclear pore(GO:0005643)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.0	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	2.7	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.2	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	1.1	GO:0005581	collagen trimer(GO:0005581)
0.0	1.2	GO:0005901	caveola(GO:0005901)
0.0	0.2	GO:0046930	pore complex(GO:0046930)
0.0	0.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.2	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	0.3	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.5	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	0.2	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0097422	tubular endosome(GO:0097422)
0.0	0.1	GO:0045495	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0	0.7	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.3	GO:0051233	spindle midzone(GO:0051233)
0.0	0.0	GO:0036194	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.7	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0044292	dendrite terminus(GO:0044292)
0.0	0.0	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.0	GO:1990812	growth cone filopodium(GO:1990812)
0.0	0.1	GO:0045178	basal part of cell(GO:0045178)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.0	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.0	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.1	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.0	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.0	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0043194	axon initial segment(GO:0043194)
0.0	0.0	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.0	GO:1990423	RZZ complex(GO:1990423)
0.0	0.2	GO:0014704	intercalated disc(GO:0014704)
0.0	0.8	GO:0000922	spindle pole(GO:0000922)
0.0	0.9	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.0	0.2	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.1	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.2	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.0	GO:0055087	Ski complex(GO:0055087)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.0	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.0	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.0	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.2	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.3	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5	2.7	GO:0042015	interleukin-20 binding(GO:0042015)
0.5	1.5	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.4	1.2	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3	0.9	GO:0035877	death effector domain binding(GO:0035877)
0.3	2.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.3	1.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.2	0.5	GO:0019961	interferon binding(GO:0019961)
0.2	3.1	GO:0043274	phospholipase binding(GO:0043274)
0.2	0.7	GO:0004126	cytidine deaminase activity(GO:0004126)
0.1	0.5	GO:0042731	PH domain binding(GO:0042731)
0.1	0.4	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.1	1.2	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.1	0.1	GO:0035851	Krueppel-associated box domain binding(GO:0035851)
0.1	1.4	GO:0070700	BMP receptor binding(GO:0070700)
0.1	0.7	GO:0008199	ferric iron binding(GO:0008199)
0.1	0.3	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.1	0.4	GO:0008865	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1	0.5	GO:0051525	NFAT protein binding(GO:0051525)
0.1	1.2	GO:0044466	2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466)
0.1	1.8	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	1.1	GO:0044548	S100 protein binding(GO:0044548)
0.1	1.4	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.1	0.3	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.1	0.2	GO:0034617	tetrahydrobiopterin binding(GO:0034617)
0.1	0.4	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.1	0.4	GO:0016004	phospholipase activator activity(GO:0016004)
0.1	0.3	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	1.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.1	0.4	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1	0.3	GO:0034584	piRNA binding(GO:0034584)
0.1	0.4	GO:0071253	connexin binding(GO:0071253)
0.1	0.2	GO:0001069	regulatory region RNA binding(GO:0001069)
0.1	0.9	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1	0.2	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.3	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.9	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	0.2	GO:0045340	mercury ion binding(GO:0045340)
0.1	0.2	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	0.2	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1	0.3	GO:0031419	cobalamin binding(GO:0031419)
0.1	0.3	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.1	0.2	GO:0003840	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.1	0.7	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.1	0.2	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1	0.3	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.1	0.6	GO:0004787	thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.1	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	0.4	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.4	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.7	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.2	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.2	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.2	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0031013	troponin I binding(GO:0031013)
0.0	0.5	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0	0.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.3	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.1	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.3	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	2.5	GO:0005518	collagen binding(GO:0005518)
0.0	0.4	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.0	0.2	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.4	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.6	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.4	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.3	GO:0031432	titin binding(GO:0031432)
0.0	3.0	GO:0001158	enhancer sequence-specific DNA binding(GO:0001158)
0.0	0.7	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.1	GO:0031493	nucleosomal histone binding(GO:0031493)
0.0	0.5	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.2	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.2	GO:0015288	porin activity(GO:0015288)
0.0	0.9	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.2	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.8	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.1	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.0	0.1	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.2	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.3	GO:0015250	water channel activity(GO:0015250)
0.0	0.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.1	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.1	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.3	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.5	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.3	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.2	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.1	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.3	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.5	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.3	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.3	GO:0048038	quinone binding(GO:0048038)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.2	GO:0001595	angiotensin receptor activity(GO:0001595)
0.0	0.1	GO:0019862	IgA binding(GO:0019862)
0.0	0.0	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	2.0	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.7	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.1	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.0	0.3	GO:0051183	vitamin transporter activity(GO:0051183)
0.0	4.1	GO:0005096	GTPase activator activity(GO:0005096)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0015216	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.1	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.2	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.3	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.3	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	1.7	GO:0008201	heparin binding(GO:0008201)
0.0	1.4	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.0	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.0	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.1	GO:0015189	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.9	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	0.1	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.0	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.6	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.0	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.0	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.0	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.0	GO:0004096	catalase activity(GO:0004096)
0.0	0.7	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0004471	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.0	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.0	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.2	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	0.3	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.4	GO:0043022	ribosome binding(GO:0043022)
0.0	0.2	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.0	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.1	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.0	GO:1990254	keratin filament binding(GO:1990254)
0.0	0.5	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.0	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	1.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1	2.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	3.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	0.3	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	0.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	1.5	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	1.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	1.9	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.5	PID ALK2 PATHWAY	ALK2 signaling events
0.0	1.1	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	1.5	PID FOXO PATHWAY	FoxO family signaling
0.0	1.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.3	PID FGF PATHWAY	FGF signaling pathway
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.5	PID E2F PATHWAY	E2F transcription factor network
0.0	0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.7	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.3	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.9	PID BMP PATHWAY	BMP receptor signaling
0.0	0.2	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.9	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.6	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	1.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.7	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.5	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.5	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.3	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.3	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.4	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.3	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.5	PID P73PATHWAY	p73 transcription factor network
0.0	0.3	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.2	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.2	PID ATR PATHWAY	ATR signaling pathway
0.0	0.0	ST STAT3 PATHWAY	STAT3 Pathway
0.0	2.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.2	2.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	3.5	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	1.4	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1	1.6	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.1	1.3	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	1.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	0.2	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.1	0.1	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1	0.8	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.8	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	4.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	1.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.9	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.9	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.6	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.2	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	1.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.6	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.0	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.2	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.3	REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	Genes involved in NCAM signaling for neurite out-growth
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.3	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.2	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.2	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.3	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.1	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	0.4	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.4	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.5	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.1	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.2	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.2	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.1	REACTOME GAP JUNCTION TRAFFICKING	Genes involved in Gap junction trafficking
0.0	0.1	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.5	REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	Genes involved in RNA Polymerase II Pre-transcription Events
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.0	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.3	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.4	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction

Results for Nr2e1

Z-value: 0.96

Motif logo

Transcription factors associated with Nr2e1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nr2e1 motif across conditions

Conditions sorted by the z-value of the Nr2e1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: