Project

ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nr3c2

Z-value: 0.75

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Transcription factors associated with Nr3c2

Gene Symbol	Gene ID	Gene Info
Nr3c2 Ensembl NCBI MGI UniProt	ENSMUSG00000031618.7	Nr3c2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Nr3c2	chr8_77132765_77133214	4976	0.232146	0.51	2.9e-05	Click!
Nr3c2	chr8_77044923_77045251	82926	0.088938	0.41	1.3e-03	Click!
Nr3c2	chr8_76902707_76902893	324	0.882397	0.39	2.0e-03	Click!
Nr3c2	chr8_76912612_76912763	4415	0.245749	0.33	9.5e-03	Click!
Nr3c2	chr8_76901608_76902608	180	0.933412	-0.23	8.2e-02	Click!

Activity of the Nr3c2 motif across conditions

Conditions sorted by the z-value of the Nr3c2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_101448217_101448875	4.30	Ifi35	interferon-induced protein 35	24	0.92
chr5_143625482_143626083	3.48	Cyth3	cytohesin 3	3248	0.24
chr16_38374654_38375717	2.81	Popdc2	popeye domain containing 2	3187	0.17
chrX_13469647_13469909	2.70	Nyx	nyctalopin	3668	0.23
chr6_34862829_34863673	2.66	Tmem140	transmembrane protein 140	11	0.96
chr2_158141899_158142209	2.46	Tgm2	transglutaminase 2, C polypeptide	2318	0.24
chr18_12257613_12257833	2.16	Ankrd29	ankyrin repeat domain 29	13974	0.14
chr12_12488453_12488685	2.11	4921511I17Rik	RIKEN cDNA 4921511I17 gene	95954	0.08
chr11_115899671_115901427	2.10	Smim5	small integral membrane protein 5	347	0.75
chr10_43518568_43518757	2.10	Gm47889	predicted gene, 47889	91	0.95
chr10_117281690_117282226	2.08	Lyz2	lysozyme 2	363	0.81
chr8_94178564_94180490	2.06	Mt1	metallothionein 1	286	0.81
chr4_115828937_115829088	2.05	Mob3c	MOB kinase activator 3C	354	0.81
chr12_103630582_103631271	1.96	Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	495	0.69
chr6_90624636_90625023	1.95	Slc41a3	solute carrier family 41, member 3	5682	0.15
chr13_112046443_112047142	1.92	Gm15323	predicted gene 15323	41290	0.14
chr15_5243498_5243891	1.86	Ptger4	prostaglandin E receptor 4 (subtype EP4)	478	0.75
chr15_36715797_36716780	1.81	Gm49263	predicted gene, 49263	7359	0.15
chr4_155468952_155469786	1.74	Tmem52	transmembrane protein 52	222	0.87
chr11_102437215_102438375	1.74	Fam171a2	family with sequence similarity 171, member A2	1982	0.17
chr16_36934847_36935880	1.73	Hcls1	hematopoietic cell specific Lyn substrate 1	380	0.77
chr7_97748212_97748509	1.70	Aqp11	aquaporin 11	10071	0.16
chr11_90686079_90686230	1.70	Tom1l1	target of myb1-like 1 (chicken)	1425	0.46
chr1_165717936_165719081	1.68	Gm37073	predicted gene, 37073	3048	0.14
chr12_76709422_76710754	1.66	Sptb	spectrin beta, erythrocytic	65	0.98
chr1_87650650_87651222	1.64	Inpp5d	inositol polyphosphate-5-phosphatase D	25303	0.15
chr2_167671877_167672567	1.62	Gm14320	predicted gene 14320	10113	0.1
chr15_102102083_102102892	1.61	Tns2	tensin 2	259	0.86
chr16_21826993_21827376	1.60	Map3k13	mitogen-activated protein kinase kinase kinase 13	1242	0.33
chr4_154024404_154026596	1.55	Smim1	small integral membrane protein 1	116	0.93
chr19_53194082_53195694	1.50	Add3	adducin 3 (gamma)	65	0.97
chr17_27056910_27058117	1.47	Itpr3	inositol 1,4,5-triphosphate receptor 3	209	0.87
chr11_69096707_69097996	1.47	Per1	period circadian clock 1	1597	0.16
chr14_46536264_46536434	1.45	Gm48912	predicted gene, 48912	19907	0.11
chr2_181079821_181080027	1.44	Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	15497	0.13
chr8_71406049_71406500	1.41	Ankle1	ankyrin repeat and LEM domain containing 1	250	0.83
chr11_34845636_34846358	1.40	Gm22022	predicted gene, 22022	3643	0.22
chr18_54436599_54436760	1.40	Redrum	Redrum, erythroid developmental long intergenic non-protein coding transcript	14384	0.22
chr1_191956577_191957080	1.36	Rd3	retinal degeneration 3	20542	0.11
chr16_34922552_34923302	1.30	Mylk	myosin, light polypeptide kinase	7415	0.19
chr3_51661793_51662907	1.29	Mgst2	microsomal glutathione S-transferase 2	1125	0.38
chr9_22136067_22136415	1.27	Acp5	acid phosphatase 5, tartrate resistant	530	0.54
chr8_111295256_111295437	1.27	Rfwd3	ring finger and WD repeat domain 3	4845	0.16
chr2_174159770_174159921	1.27	Gm10714	predicted gene 10714	24073	0.16
chr10_70127596_70128163	1.26	Ccdc6	coiled-coil domain containing 6	30758	0.2
chr17_27018044_27018864	1.26	Ggnbp1	gametogenetin binding protein 1	392	0.71
chr10_128743161_128743519	1.24	Dgka	diacylglycerol kinase, alpha	735	0.43
chr12_40016524_40017443	1.24	Arl4a	ADP-ribosylation factor-like 4A	2499	0.29
chr3_145591307_145591663	1.23	Znhit6	zinc finger, HIT type 6	4383	0.23
chr11_69915606_69917001	1.22	Gps2	G protein pathway suppressor 2	262	0.72
chr5_112288747_112288992	1.21	Tpst2	protein-tyrosine sulfotransferase 2	107	0.94
chr4_104913144_104913947	1.21	Fyb2	FYN binding protein 2	21	0.98
chr9_32342355_32342506	1.18	Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	1807	0.31
chr3_52029454_52030701	1.17	Gm37465	predicted gene, 37465	26052	0.1
chr7_80995833_80996208	1.16	Gm44967	predicted gene 44967	1337	0.26
chr7_78914724_78915335	1.12	Isg20	interferon-stimulated protein	700	0.57
chr15_6081136_6081368	1.10	Gm8047	predicted gene 8047	46291	0.16
chr19_5306588_5308182	1.09	Gm42064	predicted gene, 42064	31	0.93
chr3_89570102_89570404	1.09	Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	50089	0.1
chr1_75144472_75144783	1.08	Retreg2	reticulophagy regulator family member 2	677	0.43
chr17_47507886_47508650	1.08	Ccnd3	cyclin D3	3027	0.19
chr16_15889582_15890122	1.08	Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	1436	0.42
chr1_172510177_172510457	1.07	Gm37125	predicted gene, 37125	2932	0.14
chr8_121904943_121905414	1.07	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	2516	0.15
chr13_51846753_51848355	1.06	Gadd45g	growth arrest and DNA-damage-inducible 45 gamma	810	0.69
chr8_105831399_105831715	1.05	Tsnaxip1	translin-associated factor X (Tsnax) interacting protein 1	3805	0.1
chr5_66079108_66079628	1.04	Rbm47	RNA binding motif protein 47	1616	0.27
chr4_40849281_40849945	1.04	Mir5123	microRNA 5123	525	0.38
chr1_181255916_181257436	1.04	Rpl35a-ps2	ribosomal protein L35A, pseudogene 2	14356	0.14
chr19_5559639_5561263	1.03	1810058N15Rik	RIKEN cDNA 1810058N15 gene	191	0.47
chr11_44510011_44510178	1.01	Rnf145	ring finger protein 145	8870	0.17
chr2_30716357_30717429	0.99	Gm14488	predicted gene 14488	150	0.94
chr14_48133184_48133904	0.99	Gm49310	predicted gene, 49310	680	0.61
chr13_108670846_108671019	0.98	Rps3a3	ribosomal protein S3A3	329	0.92
chr17_45599296_45600146	0.97	Slc29a1	solute carrier family 29 (nucleoside transporters), member 1	115	0.92
chr9_21352648_21353105	0.96	Slc44a2	solute carrier family 44, member 2	4513	0.11
chr5_118480209_118480360	0.95	Gm15754	predicted gene 15754	6683	0.21
chr13_52986026_52986367	0.94	Nfil3	nuclear factor, interleukin 3, regulated	5123	0.19
chr14_76149541_76149852	0.93	Nufip1	nuclear fragile X mental retardation protein interacting protein 1	38805	0.15
chr3_84475488_84475639	0.93	Fhdc1	FH2 domain containing 1	3419	0.29
chr11_64839925_64840124	0.92	Gm12292	predicted gene 12292	3729	0.32
chr12_117744512_117744705	0.92	Rapgef5	Rap guanine nucleotide exchange factor (GEF) 5	4013	0.25
chr12_110975345_110976350	0.92	Ankrd9	ankyrin repeat domain 9	2408	0.19
chr17_56756624_56758021	0.91	Nrtn	neurturin	208	0.88
chr2_104498055_104498315	0.91	Hipk3	homeodomain interacting protein kinase 3	3739	0.19
chr8_116501999_116502150	0.90	Dynlrb2	dynein light chain roadblock-type 2	2900	0.32
chr15_83606896_83607158	0.90	Scube1	signal peptide, CUB domain, EGF-like 1	6712	0.15
chr13_75707504_75708793	0.89	Ell2	elongation factor RNA polymerase II 2	437	0.65
chr11_72429181_72429515	0.88	Ggt6	gamma-glutamyltransferase 6	6178	0.13
chr16_15948263_15948760	0.86	Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	60095	0.1
chr17_26509441_26509592	0.85	Dusp1	dual specificity phosphatase 1	997	0.39
chr4_59196198_59196829	0.81	Ugcg	UDP-glucose ceramide glucosyltransferase	6955	0.18
chr4_89524955_89525174	0.81	Gm12608	predicted gene 12608	80420	0.09
chr7_128296590_128296741	0.80	BC017158	cDNA sequence BC017158	911	0.38
chr7_127800319_127801635	0.79	Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	36	0.92
chr13_99100172_99101285	0.79	Gm807	predicted gene 807	22	0.98
chr4_24216144_24216295	0.78	Gm11892	predicted gene 11892	21881	0.28
chr6_34862527_34862817	0.78	Tmem140	transmembrane protein 140	474	0.7
chr12_73507259_73507518	0.78	Gm34016	predicted gene, 34016	1282	0.42
chr18_54907818_54907969	0.78	Zfp608	zinc finger protein 608	12331	0.2
chr11_85799424_85800600	0.77	Bcas3	breast carcinoma amplified sequence 3	1809	0.24
chr19_9978713_9979183	0.76	Fth1	ferritin heavy polypeptide 1	1650	0.22
chr1_154117439_154118596	0.76	A830008E24Rik	RIKEN cDNA A830008E24 gene	66	0.97
chr1_174171241_174171450	0.75	Spta1	spectrin alpha, erythrocytic 1	1431	0.24
chr11_95104821_95105967	0.75	Dlx3	distal-less homeobox 3	14725	0.12
chr12_58265531_58265740	0.74	Clec14a	C-type lectin domain family 14, member a	3655	0.34
chr15_82406468_82407080	0.74	Gm27331	predicted gene, 27331	379	0.39
chr4_40781630_40781889	0.74	Psenen-ps	presenilin enhancer gamma secretase subunit, pseudogene	6195	0.14
chr5_33216392_33216677	0.74	Spon2	spondin 2, extracellular matrix protein	574	0.72
chr18_10839643_10840307	0.73	Gm18764	predicted gene, 18764	19705	0.14
chr7_80994626_80994777	0.72	Gm44967	predicted gene 44967	18	0.93
chr4_133007332_133008511	0.72	Ahdc1	AT hook, DNA binding motif, containing 1	3339	0.22
chr17_5091693_5091844	0.71	Gm15599	predicted gene 15599	20342	0.23
chr13_37346508_37346993	0.71	Ly86	lymphocyte antigen 86	1361	0.39
chr10_85128093_85128664	0.70	Mterf2	mitochondrial transcription termination factor 2	351	0.86
chr6_31124166_31124436	0.70	5330406M23Rik	RIKEN cDNA 5330406M23 gene	13381	0.11
chr3_87900872_87901055	0.70	Hdgf	heparin binding growth factor	5358	0.11
chr17_40806812_40807076	0.69	Crisp2	cysteine-rich secretory protein 2	59	0.97
chr2_34565012_34565383	0.69	Gm13408	predicted gene 13408	198	0.95
chr10_81359308_81359697	0.69	Mfsd12	major facilitator superfamily domain containing 12	1950	0.11
chr16_49839981_49840391	0.67	Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	15180	0.25
chr11_32296600_32297646	0.67	Hba-a2	hemoglobin alpha, adult chain 2	495	0.66
chr5_123397462_123398184	0.67	Gm15747	predicted gene 15747	134	0.82
chr7_45126094_45126702	0.67	Snord35a	small nucleolar RNA, C/D box 35A	37	0.47
chr3_87767082_87768667	0.66	Pear1	platelet endothelial aggregation receptor 1	1061	0.43
chr11_32283784_32284776	0.65	Hba-a1	hemoglobin alpha, adult chain 1	469	0.66
chr14_88123382_88123800	0.65	Rps3a2	ribosomal protein S3A2	217	0.93
chr2_4560599_4561970	0.65	Frmd4a	FERM domain containing 4A	1509	0.43
chr1_181838056_181838455	0.65	Gm26004	predicted gene, 26004	2313	0.2
chr11_84872602_84872983	0.63	Ggnbp2	gametogenetin binding protein 2	1975	0.2
chr2_170148791_170149171	0.62	Zfp217	zinc finger protein 217	878	0.72
chr10_77440841_77441276	0.62	Gm35920	predicted gene, 35920	16859	0.15
chr19_8714838_8715424	0.61	Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	698	0.32
chr1_164405360_164405594	0.61	Gm37411	predicted gene, 37411	19236	0.14
chr7_71711939_71712090	0.61	Gm17988	predicted gene, 17988	5823	0.18
chr5_125392659_125393102	0.60	Ubc	ubiquitin C	2678	0.17
chrX_162727288_162727912	0.60	Gm15201	predicted gene 15201	9013	0.14
chr2_143889252_143889441	0.60	Gm11686	predicted gene 11686	8169	0.14
chr18_84412019_84412170	0.60	Zfp407	zinc finger protein 407	326	0.92
chr14_65805868_65806583	0.60	Pbk	PDZ binding kinase	7	0.98
chr15_12375225_12376436	0.59	Pdzd2	PDZ domain containing 2	36550	0.14
chr1_33645834_33645985	0.59	Gm17813	predicted gene, 17813	11872	0.13
chr11_32245145_32245675	0.59	Nprl3	nitrogen permease regulator-like 3	4768	0.12
chr2_38997767_38998606	0.58	Gm13496	predicted gene 13496	72	0.57
chr10_19186197_19186616	0.58	Gm20139	predicted gene, 20139	19168	0.18
chr15_82378536_82379272	0.58	Cyp2d22	cytochrome P450, family 2, subfamily d, polypeptide 22	1339	0.18
chr6_82770788_82771321	0.57	Hk2	hexokinase 2	1934	0.25
chr18_34362164_34362756	0.57	Reep5	receptor accessory protein 5	10037	0.17
chr11_49764573_49765151	0.57	Gm23813	predicted gene, 23813	6971	0.14
chr9_53609339_53609759	0.57	Acat1	acetyl-Coenzyme A acetyltransferase 1	781	0.57
chr5_92933209_92933495	0.57	Shroom3	shroom family member 3	5285	0.23
chr17_47332265_47332516	0.56	Mrps10	mitochondrial ribosomal protein S10	36497	0.1
chr6_38835149_38835559	0.56	Hipk2	homeodomain interacting protein kinase 2	1870	0.4
chr12_78205797_78206679	0.56	Gm6657	predicted gene 6657	5272	0.17
chr6_91116004_91117353	0.56	Nup210	nucleoporin 210	118	0.95
chr2_25577192_25580600	0.55	Ajm1	apical junction component 1	1001	0.25
chr16_38370407_38370971	0.55	Popdc2	popeye domain containing 2	1263	0.34
chr6_146501386_146502829	0.54	Itpr2	inositol 1,4,5-triphosphate receptor 2	71	0.97
chr9_66305145_66305804	0.54	Dapk2	death-associated protein kinase 2	37100	0.14
chr5_134314919_134315630	0.54	Gtf2i	general transcription factor II I	514	0.7
chr7_28865529_28866495	0.54	Lgals7	lectin, galactose binding, soluble 7	1557	0.2
chrX_154974620_154974827	0.54	Gm6645	predicted gene 6645	2	0.96
chr5_149643277_149643428	0.54	Gm20005	predicted gene, 20005	1742	0.28
chr6_134928964_134929556	0.54	Lockd	lncRNA downstream of Cdkn1b	105	0.9
chr8_109613033_109613184	0.53	Pkd1l3	polycystic kidney disease 1 like 3	1409	0.33
chr2_158166874_158167121	0.53	Tgm2	transglutaminase 2, C polypeptide	20561	0.13
chr3_146407041_146407816	0.53	Ssx2ip	synovial sarcoma, X 2 interacting protein	2450	0.2
chr9_106198580_106199667	0.52	Ppm1m	protein phosphatase 1M	17	0.95
chr17_29093963_29095348	0.52	1700023B13Rik	RIKEN cDNA 1700023B13 gene	194	0.82
chr5_137290070_137291279	0.52	Ache	acetylcholinesterase	1427	0.17
chr2_39008141_39008933	0.52	Arpc5l	actin related protein 2/3 complex, subunit 5-like	380	0.72
chr14_25377750_25379085	0.52	Gm26660	predicted gene, 26660	218	0.94
chr5_31697163_31697872	0.51	Rbks	ribokinase	110	0.58
chr2_119333754_119334576	0.51	Dll4	delta like canonical Notch ligand 4	5627	0.13
chr11_59960539_59961087	0.51	Rasd1	RAS, dexamethasone-induced 1	4131	0.14
chr4_130173825_130175545	0.50	Tinagl1	tubulointerstitial nephritis antigen-like 1	6	0.97
chr4_106798811_106800382	0.50	Acot11	acyl-CoA thioesterase 11	194	0.93
chr12_44270345_44270549	0.50	Pnpla8	patatin-like phospholipase domain containing 8	1280	0.31
chr2_128700549_128700956	0.50	Mertk	MER proto-oncogene tyrosine kinase	1796	0.3
chr4_154926533_154926891	0.50	Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	1365	0.31
chr5_129730231_129730850	0.49	Gm15903	predicted gene 15903	2368	0.17
chr3_148958783_148960002	0.48	Adgrl2	adhesion G protein-coupled receptor L2	4605	0.24
chr16_58498366_58498517	0.48	St3gal6	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	900	0.59
chr9_32940723_32941376	0.48	Gm27162	predicted gene 27162	12083	0.21
chr2_70425556_70425707	0.48	Rpl9-ps7	ribosomal protein L9, pseudogene 7	33351	0.14
chr19_57361091_57362043	0.47	Fam160b1	family with sequence similarity 160, member B1	537	0.55
chr8_94035053_94035555	0.47	Nudt21	nudix (nucleoside diphosphate linked moiety X)-type motif 21	1702	0.22
chr4_63557098_63557688	0.47	Tmem268	transmembrane protein 268	1388	0.3
chr12_47139542_47139693	0.47	Gm36971	predicted gene, 36971	25425	0.24
chr15_77931320_77931782	0.47	Txn2	thioredoxin 2	2545	0.21
chr17_35896363_35897367	0.46	Gm16279	predicted gene 16279	81	0.64
chr19_15941445_15941936	0.46	Gm3329	predicted gene 3329	1920	0.31
chr16_96192359_96192600	0.46	Lca5l	Leber congenital amaurosis 5-like	208	0.92
chr5_31048714_31049304	0.45	Slc5a6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	85	0.68
chr8_84203803_84204350	0.45	Gm37352	predicted gene, 37352	3207	0.07
chr14_30921218_30921369	0.45	Itih3	inter-alpha trypsin inhibitor, heavy chain 3	2256	0.18
chr17_57248057_57248976	0.45	Gpr108	G protein-coupled receptor 108	70	0.92
chr5_113945581_113945982	0.45	Gm42797	predicted gene 42797	15647	0.11
chr14_101872557_101872708	0.44	Lmo7	LIM domain only 7	3162	0.35
chr7_25385870_25386460	0.44	Lipe	lipase, hormone sensitive	1239	0.23

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr3c2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.5	1.8	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.4	1.1	GO:0060468	prevention of polyspermy(GO:0060468)
0.2	0.7	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.2	0.6	GO:0060931	sinoatrial node cell development(GO:0060931)
0.2	1.3	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.2	0.6	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.2	0.5	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.2	0.7	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.1	0.4	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.2	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.1	1.3	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.1	0.4	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.1	0.3	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.1	0.8	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1	0.3	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	0.3	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.7	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.1	0.1	GO:0061687	detoxification of inorganic compound(GO:0061687)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.3	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.1	1.4	GO:0014850	response to muscle activity(GO:0014850)
0.1	0.9	GO:0015858	nucleoside transport(GO:0015858)
0.1	0.2	GO:0032672	regulation of interleukin-3 production(GO:0032672)
0.1	0.6	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1	1.8	GO:0033014	porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.1	0.2	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.1	0.3	GO:0071918	urea transmembrane transport(GO:0071918)
0.1	0.2	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1	0.1	GO:2000598	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.1	0.3	GO:0035864	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1	0.9	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1	0.2	GO:0071462	cellular response to water stimulus(GO:0071462)
0.1	0.3	GO:0035188	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1	1.8	GO:0019835	cytolysis(GO:0019835)
0.1	0.2	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.1	0.3	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.1	0.2	GO:0008228	opsonization(GO:0008228)
0.1	0.5	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.1	0.2	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.1	0.2	GO:0002432	granuloma formation(GO:0002432)
0.1	0.2	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.1	0.3	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.1	0.7	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.1	0.1	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.1	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.0	1.8	GO:0032873	negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.0	0.4	GO:0071361	cellular response to ethanol(GO:0071361)
0.0	0.2	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.2	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	1.0	GO:0048821	erythrocyte development(GO:0048821)
0.0	0.1	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.8	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.0	1.0	GO:0000266	mitochondrial fission(GO:0000266)
0.0	0.3	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0	0.2	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.3	GO:0019321	pentose metabolic process(GO:0019321)
0.0	0.3	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.5	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.1	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.2	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.5	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.1	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.0	0.2	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	0.1	GO:0002278	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0	0.2	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	0.1	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.2	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0	0.3	GO:0097062	dendritic spine maintenance(GO:0097062)
0.0	0.1	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.1	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.1	GO:0005984	disaccharide metabolic process(GO:0005984)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.2	GO:0033572	transferrin transport(GO:0033572)
0.0	0.1	GO:0016553	adenosine to inosine editing(GO:0006382) base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.1	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.1	GO:1901894	regulation of calcium-transporting ATPase activity(GO:1901894)
0.0	0.6	GO:0006308	DNA catabolic process(GO:0006308)
0.0	0.1	GO:0033058	directional locomotion(GO:0033058)
0.0	0.1	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.2	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.0	0.1	GO:0051121	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.1	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.0	0.1	GO:0043652	engulfment of apoptotic cell(GO:0043652)
0.0	0.1	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0	0.1	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:0007060	male meiosis chromosome segregation(GO:0007060)
0.0	0.1	GO:0071316	cellular response to nicotine(GO:0071316)
0.0	0.1	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.3	GO:0001953	negative regulation of cell-matrix adhesion(GO:0001953)
0.0	0.5	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.1	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.2	GO:0060068	vagina development(GO:0060068)
0.0	0.2	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.2	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.0	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0	0.1	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.1	GO:1904491	protein localization to ciliary transition zone(GO:1904491)
0.0	0.0	GO:0060264	regulation of respiratory burst involved in inflammatory response(GO:0060264)
0.0	0.1	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.5	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.2	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.0	0.1	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0	0.1	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	0.2	GO:0097286	iron ion import(GO:0097286)
0.0	0.1	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.2	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.0	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.1	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.1	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	0.1	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0	0.0	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.0	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.0	0.0	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	0.1	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.1	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.0	0.1	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.0	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.1	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.0	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.1	GO:0060352	cell adhesion molecule production(GO:0060352)
0.0	0.2	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.4	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.0	GO:0090156	negative regulation of sphingolipid biosynthetic process(GO:0090155) cellular sphingolipid homeostasis(GO:0090156) negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.0	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
0.0	0.2	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.1	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.2	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.8	GO:0021675	nerve development(GO:0021675)
0.0	0.1	GO:0045213	neurotransmitter receptor metabolic process(GO:0045213)
0.0	0.1	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.2	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.0	GO:1903147	negative regulation of mitophagy(GO:1903147)
0.0	0.0	GO:0010446	response to alkaline pH(GO:0010446)
0.0	0.0	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.0	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.0	GO:2000325	regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0042136	neurotransmitter biosynthetic process(GO:0042136)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0030825	positive regulation of cGMP metabolic process(GO:0030825)
0.0	0.0	GO:0010535	positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0	0.0	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0006662	glycerol ether metabolic process(GO:0006662)
0.0	0.1	GO:0002192	IRES-dependent translational initiation(GO:0002192) IRES-dependent viral translational initiation(GO:0075522)
0.0	0.2	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.0	GO:0021776	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.0	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0	0.3	GO:0001706	endoderm formation(GO:0001706)
0.0	0.1	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.1	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.0	0.0	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0032308	positive regulation of prostaglandin secretion(GO:0032308)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.7	GO:0008091	spectrin(GO:0008091)
0.3	1.7	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.2	1.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	1.3	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	0.4	GO:0070761	pre-snoRNP complex(GO:0070761)
0.1	0.5	GO:0008385	IkappaB kinase complex(GO:0008385)
0.1	0.2	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.2	GO:0097452	GAIT complex(GO:0097452)
0.0	0.2	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.0	0.4	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.8	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.1	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.4	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.1	GO:0005712	chiasma(GO:0005712)
0.0	0.1	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.7	GO:0015030	Cajal body(GO:0015030)
0.0	0.2	GO:0017059	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.4	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.3	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.3	GO:0043194	axon initial segment(GO:0043194)
0.0	0.0	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.1	GO:0089701	U2AF(GO:0089701)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	1.8	GO:0000794	condensed nuclear chromosome(GO:0000794)
0.0	0.2	GO:0042382	paraspeckles(GO:0042382)
0.0	0.0	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.3	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.6	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.2	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.9	GO:0005643	nuclear pore(GO:0005643)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.9	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	0.6	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.1	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.0	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.2	GO:0071565	nBAF complex(GO:0071565)
0.0	0.8	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.0	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.0	GO:0000836	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.3	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.9	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.3	1.4	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.2	1.0	GO:0031720	haptoglobin binding(GO:0031720)
0.2	0.6	GO:0030620	U2 snRNA binding(GO:0030620)
0.2	1.7	GO:0003796	lysozyme activity(GO:0003796)
0.1	0.4	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1	1.9	GO:0030506	ankyrin binding(GO:0030506)
0.1	0.4	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	0.3	GO:0015265	urea channel activity(GO:0015265)
0.1	0.3	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.5	GO:0008420	CTD phosphatase activity(GO:0008420)
0.1	0.7	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1	0.3	GO:0016453	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1	0.7	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1	0.7	GO:0003993	acid phosphatase activity(GO:0003993)
0.1	0.9	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.1	0.3	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.1	1.5	GO:0030487	inositol-4,5-bisphosphate 5-phosphatase activity(GO:0030487)
0.1	0.2	GO:0016361	activin receptor activity, type I(GO:0016361)
0.1	0.2	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1	0.6	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.1	0.2	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.2	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.3	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	0.5	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.1	0.2	GO:0019145	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.3	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.9	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.3	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0030250	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.5	GO:0034843	2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466)
0.0	2.0	GO:0005507	copper ion binding(GO:0005507)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0008865	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.0	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0	0.2	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.6	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	1.7	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0	0.2	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.2	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0052794	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0	0.2	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.1	GO:0070905	serine binding(GO:0070905)
0.0	0.2	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.1	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.0	0.1	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.7	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.5	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0031544	peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.1	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.3	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	2.3	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.6	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	1.2	GO:0008146	sulfotransferase activity(GO:0008146)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.0	GO:0016662	oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0018572	2,3-dihydroxy DDT 1,2-dioxygenase activity(GO:0018542) phenanthrene dioxygenase activity(GO:0018555) 2,2',3-trihydroxybiphenyl dioxygenase activity(GO:0018556) 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity(GO:0018557) 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity(GO:0018558) 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity(GO:0018559) protocatechuate 3,4-dioxygenase type II activity(GO:0018560) 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity(GO:0018561) 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity(GO:0018562) 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity(GO:0018563) carbazole 1,9a-dioxygenase activity(GO:0018564) dihydroxydibenzothiophene dioxygenase activity(GO:0018565) 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity(GO:0018566) styrene dioxygenase activity(GO:0018567) 3,4-dihydroxyphenanthrene dioxygenase activity(GO:0018568) hydroquinone 1,2-dioxygenase activity(GO:0018569) p-cumate 2,3-dioxygenase activity(GO:0018570) 2,3-dihydroxy-p-cumate dioxygenase activity(GO:0018571) 3,5-dichlorocatechol 1,2-dioxygenase activity(GO:0018572) 2-aminophenol 1,6-dioxygenase activity(GO:0018573) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity(GO:0018574) chlorocatechol 1,2-dioxygenase activity(GO:0018575) catechol dioxygenase activity(GO:0019114) dihydroxyfluorene dioxygenase activity(GO:0019117) 5-aminosalicylate dioxygenase activity(GO:0034543) 3-hydroxy-2-naphthoate 2,3-dioxygenase activity(GO:0034803) benzo(a)pyrene 11,12-dioxygenase activity(GO:0034806) benzo(a)pyrene 4,5-dioxygenase activity(GO:0034808) 4,5-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034810) benzo(a)pyrene 9,10-dioxygenase activity(GO:0034811) 9,10-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034812) benzo(a)pyrene 7,8-dioxygenase activity(GO:0034813) 7,8-dihydroxy benzo(a)pyrene dioxygenase activity(GO:0034814) 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity(GO:0034827) 2-mercaptobenzothiazole dioxygenase activity(GO:0034834) pyridine-3,4-diol dioxygenase activity(GO:0034895) pyrene dioxygenase activity(GO:0034920) 4,5-dihydroxypyrene dioxygenase activity(GO:0034922) phenanthrene-4-carboxylate dioxygenase activity(GO:0034934) tetrachlorobenzene dioxygenase activity(GO:0034935) 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity(GO:0034936) 2,3-dihydroxydiphenyl ether dioxygenase activity(GO:0034955) diphenyl ether 1,2-dioxygenase activity(GO:0034956) arachidonate 8(S)-lipoxygenase activity(GO:0036403) 4-hydroxycatechol 1,2-dioxygenase activity(GO:0047074)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.2	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.0	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	1.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.3	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.0	GO:0102345	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.1	GO:0035174	histone serine kinase activity(GO:0035174)
0.0	0.3	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.2	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.3	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.3	GO:0070330	aromatase activity(GO:0070330)
0.0	0.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.1	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.9	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	2.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.9	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.7	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.7	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.4	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.3	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.4	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	0.2	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.8	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.2	1.4	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	4.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	1.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	0.7	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	1.2	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	0.8	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.7	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	0.3	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.4	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.0	1.4	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.5	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.5	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.5	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.5	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis