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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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Results for Nr6a1

Z-value: 0.63

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Transcription factors associated with Nr6a1

Gene Symbol	Gene ID	Gene Info
Nr6a1 Ensembl NCBI MGI UniProt	ENSMUSG00000063972.7	nuclear receptor subfamily 6, group A, member 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_38784133_38784675	Nr6a1	65	0.954810	0.25	5.0e-02	Click!
chr2_38924469_38924620	Nr6a1	1673	0.230824	-0.25	5.8e-02	Click!
chr2_38927552_38927938	Nr6a1	57	0.951716	0.23	7.6e-02	Click!
chr2_38923092_38923296	Nr6a1	3023	0.147837	-0.23	7.8e-02	Click!
chr2_38915140_38915323	Nr6a1	10986	0.105994	-0.23	7.8e-02	Click!

Activity of the Nr6a1 motif across conditions

Conditions sorted by the z-value of the Nr6a1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_163395773_163396078	2.01	Jph2	junctophilin 2	2024	0.24
chr5_32137776_32137927	1.79	Fosl2	fos-like antigen 2	1678	0.31
chr3_84189998_84191469	1.77	Trim2	tripartite motif-containing 2	210	0.94
chr10_97481185_97481829	1.65	Dcn	decorin	860	0.67
chr5_102724663_102726037	1.57	Arhgap24	Rho GTPase activating protein 24	377	0.93
chr19_7558753_7558904	1.27	Plaat3	phospholipase A and acyltransferase 3	1343	0.39
chr2_71273883_71274736	1.26	Slc25a12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	8480	0.19
chr6_119195676_119196202	1.25	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	292	0.91
chr11_106381435_106381885	1.24	Icam2	intercellular adhesion molecule 2	859	0.5
chr9_110765100_110765787	1.24	Myl3	myosin, light polypeptide 3	418	0.74
chr18_11060814_11061287	1.18	Gata6	GATA binding protein 6	2003	0.37
chr2_143917101_143917550	1.17	Dstn	destrin	2005	0.27
chr5_137610176_137611504	1.15	Pcolce	procollagen C-endopeptidase enhancer protein	138	0.86
chr18_80362351_80362669	1.10	D330025C20Rik	RIKEN cDNA D330025C20 gene	271	0.79
chr11_119392018_119392570	1.10	Rnf213	ring finger protein 213	806	0.49
chr18_65393472_65393826	1.07	Alpk2	alpha-kinase 2	245	0.87
chr15_82378536_82379272	0.99	Cyp2d22	cytochrome P450, family 2, subfamily d, polypeptide 22	1339	0.18
chr10_68541127_68542141	0.99	Cabcoco1	ciliary associated calcium binding coiled-coil 1	262	0.94
chr1_171439752_171440231	0.98	F11r	F11 receptor	2412	0.15
chr8_13202008_13202379	0.97	2810030D12Rik	RIKEN cDNA 2810030D12 gene	1373	0.23
chr4_32363647_32363850	0.96	Bach2	BTB and CNC homology, basic leucine zipper transcription factor 2	53687	0.15
chr3_129330284_129331144	0.93	Enpep	glutamyl aminopeptidase	1550	0.35
chr6_6212569_6212720	0.92	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	4474	0.27
chr3_144759210_144759685	0.91	Clca3a1	chloride channel accessory 3A1	1394	0.3
chr3_129902773_129902924	0.89	Casp6	caspase 6	1347	0.38
chr16_92356332_92356564	0.88	Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	2426	0.19
chr2_36216770_36217471	0.84	Gm13431	predicted gene 13431	295	0.84
chr7_24500255_24500896	0.84	Cadm4	cell adhesion molecule 4	614	0.51
chr11_117231910_117232833	0.83	Septin9	septin 9	86	0.97
chr1_78817332_78818790	0.83	Kcne4	potassium voltage-gated channel, Isk-related subfamily, gene 4	1134	0.48
chr9_74110075_74111065	0.83	Wdr72	WD repeat domain 72	166	0.97
chr14_63318245_63318396	0.82	Gm49390	predicted gene, 49390	575	0.72
chr19_38042337_38042611	0.82	Myof	myoferlin	877	0.52
chr11_43821050_43821315	0.82	Adra1b	adrenergic receptor, alpha 1b	15150	0.23
chrX_106135756_106136481	0.77	Tlr13	toll-like receptor 13	7086	0.16
chr4_19707395_19707716	0.77	Wwp1	WW domain containing E3 ubiquitin protein ligase 1	1438	0.45
chr10_81128980_81129986	0.75	Map2k2	mitogen-activated protein kinase kinase 2	868	0.33
chr12_24892433_24892740	0.75	Mboat2	membrane bound O-acyltransferase domain containing 2	60955	0.09
chr15_103250315_103251530	0.75	Nfe2	nuclear factor, erythroid derived 2	543	0.62
chr17_47467845_47469202	0.74	1700001C19Rik	RIKEN cDNA 1700001C19 gene	31147	0.09
chr1_184846422_184846573	0.74	Mtarc2	mitochondrial amidoxime reducing component 2	46	0.97
chr18_46668983_46669540	0.72	Gm3734	predicted gene 3734	38454	0.1
chr7_4751858_4753020	0.71	Cox6b2	cytochrome c oxidase subunit 6B2	89	0.92
chr1_179059510_179060167	0.70	Smyd3	SET and MYND domain containing 3	70493	0.13
chr5_51548617_51548781	0.69	Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	5172	0.21
chr15_73750483_73751713	0.67	Ptp4a3	protein tyrosine phosphatase 4a3	2724	0.24
chr2_59615026_59615433	0.67	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	3154	0.32
chr5_134745620_134746234	0.66	Gm30003	predicted gene, 30003	1115	0.35
chr19_46624649_46624800	0.66	Wbp1l	WW domain binding protein 1 like	1323	0.35
chr7_118241830_118242099	0.65	Smg1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	1385	0.3
chr11_111067503_111068134	0.65	Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	1654	0.5
chr6_58642449_58642948	0.63	Abcg2	ATP binding cassette subfamily G member 2 (Junior blood group)	2116	0.36
chr18_84091449_84092719	0.63	Zadh2	zinc binding alcohol dehydrogenase, domain containing 2	3413	0.19
chr1_65112211_65113305	0.63	Gm28845	predicted gene 28845	6800	0.1
chr6_52257098_52257896	0.63	9530018H14Rik	RIKEN cDNA 9530018H14 gene	37	0.92
chr7_110818849_110819014	0.62	Rnf141	ring finger protein 141	2352	0.23
chr4_111886523_111886676	0.62	Slc5a9	solute carrier family 5 (sodium/glucose cotransporter), member 9	2345	0.3
chr10_128738683_128738834	0.62	Dgka	diacylglycerol kinase, alpha	5317	0.09
chr19_53673750_53674154	0.62	Rbm20	RNA binding motif protein 20	3354	0.24
chr17_35821748_35823149	0.61	Ier3	immediate early response 3	764	0.28
chr8_84711904_84712777	0.61	Nfix	nuclear factor I/X	1728	0.2
chr7_128270317_128271410	0.60	Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	289	0.79
chr4_57569383_57569972	0.60	Pakap	paralemmin A kinase anchor protein	1347	0.55
chr16_35659651_35660734	0.60	Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	757	0.67
chr17_81732231_81732916	0.60	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	5804	0.3
chr12_69574100_69574682	0.59	Vcpkmt	valosin containing protein lysine (K) methyltransferase	8544	0.14
chr8_83575796_83577746	0.59	D830024N08Rik	RIKEN cDNA D830024N08 gene	727	0.44
chr11_100969289_100970720	0.59	Cavin1	caveolae associated 1	547	0.68
chr12_110843900_110844184	0.59	Gm26912	predicted gene, 26912	1174	0.27
chr10_30840937_30841237	0.58	Hey2	hairy/enhancer-of-split related with YRPW motif 2	928	0.55
chr1_74027276_74028287	0.58	Tns1	tensin 1	9352	0.23
chr5_114175498_114176701	0.58	Acacb	acetyl-Coenzyme A carboxylase beta	193	0.92
chr18_60645396_60645912	0.58	Synpo	synaptopodin	2618	0.26
chr9_20868528_20869547	0.57	Shfl	shiftless antiviral inhibitor of ribosomal frameshifting	240	0.82
chr7_134222911_134223711	0.57	Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	1786	0.37
chr5_108674331_108674482	0.57	Slc26a1	solute carrier family 26 (sulfate transporter), member 1	347	0.78
chr8_80497324_80498362	0.56	Gypa	glycophorin A	4062	0.27
chr4_132973841_132975368	0.56	Fgr	FGR proto-oncogene, Src family tyrosine kinase	502	0.76
chr5_119137444_119138294	0.56	1700081H04Rik	RIKEN cDNA 1700081H04 gene	29635	0.2
chr13_53472002_53473141	0.55	Msx2	msh homeobox 2	503	0.8
chr8_96577050_96577538	0.55	1700047G07Rik	RIKEN cDNA 1700047G07 gene	64952	0.13
chr13_38526290_38526876	0.55	Gm31834	predicted gene, 31834	820	0.43
chr15_85645713_85647012	0.54	Gm49539	predicted gene, 49539	279	0.89
chr14_63235525_63236294	0.53	Gata4	GATA binding protein 4	9339	0.17
chr5_144507108_144507703	0.53	Nptx2	neuronal pentraxin 2	38497	0.17
chr4_98108504_98108946	0.53	Gm12691	predicted gene 12691	37874	0.2
chr3_123164422_123164582	0.52	Gm43287	predicted gene 43287	30	0.97
chr2_131559454_131560024	0.52	Gm14285	predicted gene 14285	1875	0.29
chr2_127729042_127730365	0.52	Mall	mal, T cell differentiation protein-like	229	0.9
chrX_157701658_157702782	0.51	Smpx	small muscle protein, X-linked	378	0.83
chr10_105526951_105527102	0.51	Gm15664	predicted gene 15664	6566	0.13
chr11_96074134_96074285	0.51	Atp5g1	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)	828	0.42
chr18_65025085_65025364	0.51	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	578	0.79
chr3_39460233_39460840	0.51	Gm9845	predicted pseudogene 9845	101633	0.08
chr2_148441004_148443557	0.51	Cd93	CD93 antigen	1283	0.41
chr15_95805007_95805158	0.51	Gm49173	predicted gene, 49173	681	0.57
chr11_114072204_114072652	0.50	Sdk2	sidekick cell adhesion molecule 2	5382	0.24
chr12_110487974_110488308	0.50	Gm19605	predicted gene, 19605	1933	0.27
chr1_195091807_195092906	0.50	Cd46	CD46 antigen, complement regulatory protein	107	0.94
chr1_74806289_74808675	0.50	Wnt10a	wingless-type MMTV integration site family, member 10A	14119	0.11
chr7_143106768_143108439	0.50	Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	52	0.95
chr10_7473717_7473913	0.49	Ulbp1	UL16 binding protein 1	177	0.95
chr13_93494772_93495201	0.49	Jmy	junction-mediating and regulatory protein	4751	0.2
chr10_98572877_98573494	0.48	Gm34297	predicted gene, 34297	35703	0.2
chr14_62751561_62751747	0.48	Ints6	integrator complex subunit 6	9458	0.16
chr13_64248041_64249406	0.48	1810034E14Rik	RIKEN cDNA 1810034E14 gene	5	0.55
chr13_50958059_50958704	0.48	Gm19009	predicted gene, 19009	98225	0.07
chr10_107901520_107901895	0.47	Otogl	otogelin-like	10427	0.26
chr9_25483755_25485057	0.47	Eepd1	endonuclease/exonuclease/phosphatase family domain containing 1	1539	0.42
chr19_57417994_57418728	0.47	Gm50271	predicted gene, 50271	5133	0.19
chr1_162217585_162219370	0.47	Dnm3os	dynamin 3, opposite strand	601	0.46
chr18_80193737_80193888	0.47	Rbfa	ribosome binding factor A	1391	0.23
chr18_12335527_12335869	0.47	Lama3	laminin, alpha 3	1879	0.31
chr8_123097655_123097806	0.46	Spg7	SPG7, paraplegin matrix AAA peptidase subunit	3209	0.11
chr10_12812894_12813893	0.46	Utrn	utrophin	156	0.96
chr19_60873441_60873948	0.46	Prdx3	peroxiredoxin 3	862	0.51
chr8_107944624_107945451	0.46	Zfhx3	zinc finger homeobox 3	2393	0.38
chr5_119838189_119838772	0.46	Tbx5	T-box 5	2325	0.27
chr3_101367155_101367578	0.46	Igsf3	immunoglobulin superfamily, member 3	9717	0.15
chr4_132397551_132398511	0.45	Phactr4	phosphatase and actin regulator 4	168	0.89
chr14_105589341_105590435	0.45	9330188P03Rik	RIKEN cDNA 9330188P03 gene	169	0.95
chr10_117840985_117841282	0.45	Rap1b	RAS related protein 1b	4902	0.16
chr2_135439627_135440202	0.45	9630028H03Rik	RIKEN cDNA 9630028H03 gene	143382	0.04
chr13_38145014_38146012	0.45	Dsp	desmoplakin	5781	0.18
chr9_95256675_95257394	0.45	Slc9a9	solute carrier family 9 (sodium/hydrogen exchanger), member 9	135348	0.04
chr14_31211131_31211749	0.44	Tnnc1	troponin C, cardiac/slow skeletal	3108	0.13
chr1_152623256_152624209	0.44	Rgl1	ral guanine nucleotide dissociation stimulator,-like 1	1297	0.51
chr2_70838589_70839075	0.44	Tlk1	tousled-like kinase 1	13104	0.18
chr8_108886846_108887288	0.44	Gm38318	predicted gene, 38318	19505	0.2
chrX_16816296_16817707	0.44	Maob	monoamine oxidase B	274	0.95
chr9_57763587_57763764	0.44	Clk3	CDC-like kinase 3	633	0.65
chr1_133798392_133798998	0.43	Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	2341	0.23
chr19_24029116_24029267	0.43	Fam189a2	family with sequence similarity 189, member A2	1828	0.33
chr13_38353572_38354204	0.43	Bmp6	bone morphogenetic protein 6	7735	0.17
chr4_45529877_45530765	0.43	Shb	src homology 2 domain-containing transforming protein B	9	0.97
chr6_34609817_34610100	0.43	Cald1	caldesmon 1	11338	0.19
chr8_57354784_57355185	0.43	5033428I22Rik	RIKEN cDNA 5033428I22 gene	14184	0.13
chr8_40863729_40864362	0.42	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	1467	0.34
chr1_34129998_34130149	0.42	Dst	dystonin	8823	0.17
chr15_77202074_77202631	0.42	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	1084	0.46
chr11_32294517_32294773	0.42	Hba-a2	hemoglobin alpha, adult chain 2	1844	0.2
chr17_16889285_16889779	0.42	Gm7483	predicted gene 7483	177	0.95
chr7_127217459_127218630	0.42	Septin1	septin 1	187	0.85
chr13_52060340_52060549	0.42	Gm48190	predicted gene, 48190	36198	0.14
chr11_66985344_66985531	0.42	Gm12299	predicted gene 12299	16649	0.13
chr7_4516649_4516857	0.42	Tnnt1	troponin T1, skeletal, slow	371	0.69
chr13_24806238_24806432	0.42	BC005537	cDNA sequence BC005537	4315	0.14
chr19_46510443_46510594	0.41	Trim8	tripartite motif-containing 8	4142	0.18
chr6_54971822_54971973	0.41	Nod1	nucleotide-binding oligomerization domain containing 1	236	0.91
chr16_12697234_12697440	0.41	Gm38619	predicted gene, 38619	7031	0.28
chr2_26339789_26340241	0.41	Gpsm1	G-protein signalling modulator 1 (AGS3-like, C. elegans)	567	0.56
chr15_59680309_59681106	0.41	Gm20150	predicted gene, 20150	8594	0.22
chr11_11691275_11691620	0.41	Gm12000	predicted gene 12000	4992	0.18
chr10_103142909_103143169	0.40	Lrriq1	leucine-rich repeats and IQ motif containing 1	3336	0.27
chr17_57276011_57276681	0.40	Vav1	vav 1 oncogene	2754	0.17
chr1_187608598_187610131	0.40	Esrrg	estrogen-related receptor gamma	332	0.91
chr5_74632969_74633120	0.40	Lnx1	ligand of numb-protein X 1	9523	0.19
chr2_114048099_114048464	0.40	Actc1	actin, alpha, cardiac muscle 1	4606	0.18
chr9_59684016_59684167	0.40	Gramd2	GRAM domain containing 2	3947	0.16
chr11_51648294_51649457	0.40	N4bp3	NEDD4 binding protein 3	1945	0.2
chr15_101138908_101139059	0.40	Acvrl1	activin A receptor, type II-like 1	1383	0.29
chr19_6968781_6970375	0.39	Plcb3	phospholipase C, beta 3	130	0.89
chr19_57272093_57272296	0.39	4930449E18Rik	RIKEN cDNA 4930449E18 gene	1766	0.37
chr10_116986532_116987280	0.39	Best3	bestrophin 3	592	0.61
chr6_52251199_52251449	0.39	Hoxa11os	homeobox A11, opposite strand	2902	0.08
chr3_9334054_9335134	0.39	C030034L19Rik	RIKEN cDNA C030034L19 gene	68470	0.11
chr17_72921491_72924008	0.39	Lbh	limb-bud and heart	1561	0.47
chr11_101771824_101772990	0.39	Etv4	ets variant 4	226	0.91
chr11_88849197_88849437	0.39	Akap1	A kinase (PRKA) anchor protein 1	2186	0.23
chr2_25054469_25055450	0.39	Gm24328	predicted gene, 24328	216	0.68
chr7_108929500_108930178	0.38	Nlrp10	NLR family, pyrin domain containing 10	339	0.81
chr6_118819427_118819578	0.38	Gm25905	predicted gene, 25905	15398	0.24
chr8_120275935_120277234	0.38	Gse1	genetic suppressor element 1, coiled-coil protein	48128	0.12
chr12_73587917_73588487	0.38	Prkch	protein kinase C, eta	3359	0.25
chr14_8408866_8409237	0.38	Gm8416	predicted gene 8416	134	0.96
chr1_43196103_43196958	0.38	Fhl2	four and a half LIM domains 2	231	0.93
chr8_34752986_34753476	0.38	Dusp4	dual specificity phosphatase 4	54066	0.12
chr1_186587900_186588171	0.38	A730004F24Rik	RIKEN cDNA A730004F24 gene	29354	0.18
chr18_53249928_53250416	0.38	Snx24	sorting nexing 24	4403	0.25
chr15_85670939_85672357	0.38	Lncppara	long noncoding RNA near Ppara	18032	0.13
chr13_112460134_112460285	0.37	Il6st	interleukin 6 signal transducer	3861	0.19
chr1_23274015_23274590	0.37	Mir30a	microRNA 30a	2033	0.21
chr13_51408385_51410292	0.37	S1pr3	sphingosine-1-phosphate receptor 3	699	0.69
chr6_125320913_125322109	0.37	Scnn1a	sodium channel, nonvoltage-gated 1 alpha	10	0.96
chr10_77187782_77188266	0.37	Col18a1	collagen, type XVIII, alpha 1	21476	0.17
chr1_150992792_150993732	0.37	Hmcn1	hemicentin 1	173	0.95
chr19_5874269_5874420	0.37	Frmd8	FERM domain containing 8	895	0.33
chr2_11534808_11535247	0.36	Gm37975	predicted gene, 37975	333	0.84
chr5_138990246_138990397	0.36	Pdgfa	platelet derived growth factor, alpha	3960	0.21
chr9_26804636_26804787	0.36	Glb1l2	galactosidase, beta 1-like 2	1013	0.54
chr19_5821858_5822796	0.36	Gm27702	predicted gene, 27702	2380	0.12
chr10_97568252_97568843	0.36	Lum	lumican	3419	0.23
chr15_78598536_78598827	0.35	Cyth4	cytohesin 4	1532	0.27
chr10_40285580_40285776	0.35	Gm47867	predicted gene, 47867	3625	0.13
chr3_108070155_108070321	0.35	Ampd2	adenosine monophosphate deaminase 2	5232	0.09
chr17_56263000_56263327	0.35	Fem1a	fem 1 homolog a	6353	0.09
chr6_24597837_24598262	0.35	Lmod2	leiomodin 2 (cardiac)	287	0.88
chr1_75360071_75361415	0.34	Des	desmin	414	0.72
chr10_80347716_80349512	0.34	Adamtsl5	ADAMTS-like 5	202	0.82
chr9_21228344_21228495	0.34	Gm16754	predicted gene, 16754	3016	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr6a1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.4	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.3	1.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3	1.2	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.2	0.7	GO:0007525	somatic muscle development(GO:0007525)
0.2	0.5	GO:2001055	positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.2	0.5	GO:0060454	positive regulation of gastric acid secretion(GO:0060454)
0.2	0.5	GO:0043382	positive regulation of memory T cell differentiation(GO:0043382)
0.1	0.4	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.7	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.1	0.7	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1	0.3	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.1	0.5	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1	0.5	GO:0003186	tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195)
0.1	0.5	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1	0.4	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.1	0.3	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.1	0.3	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1	0.4	GO:0019532	oxalate transport(GO:0019532)
0.1	0.4	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.1	0.3	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.1	0.3	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1	0.2	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.1	0.3	GO:0002525	acute inflammatory response to non-antigenic stimulus(GO:0002525)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.4	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1	0.2	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.1	0.4	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.1	0.2	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.1	0.2	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.1	0.5	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1	0.1	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.1	0.2	GO:0051891	positive regulation of cardioblast differentiation(GO:0051891)
0.1	0.2	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1	0.4	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.1	0.2	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.1	0.1	GO:0071608	macrophage inflammatory protein-1 alpha production(GO:0071608)
0.1	0.4	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.1	0.9	GO:0070166	enamel mineralization(GO:0070166)
0.1	0.6	GO:0097062	dendritic spine maintenance(GO:0097062)
0.1	0.5	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.2	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1	0.3	GO:2000318	positive regulation of T-helper 17 type immune response(GO:2000318)
0.1	0.2	GO:0071415	cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.1	0.1	GO:0002086	diaphragm contraction(GO:0002086)
0.1	0.2	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.1	0.2	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.1	0.2	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0060486	Clara cell differentiation(GO:0060486)
0.0	0.1	GO:0090258	negative regulation of mitochondrial fission(GO:0090258)
0.0	0.3	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.2	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.3	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.2	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.1	GO:0051140	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.2	GO:0046618	drug export(GO:0046618)
0.0	0.2	GO:0032962	positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.2	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.5	GO:0051014	actin filament severing(GO:0051014)
0.0	0.2	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0032803	low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.0	0.3	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.6	GO:0060045	positive regulation of cardiac muscle cell proliferation(GO:0060045)
0.0	0.5	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.2	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0072275	metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.2	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	1.0	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.3	GO:0007351	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	0.1	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.2	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.1	GO:0061055	myotome development(GO:0061055)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:1903352	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0	0.3	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.3	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0	0.1	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.2	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
0.0	0.3	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.2	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0	0.1	GO:0071033	nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0	0.1	GO:0009093	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0061325	cell proliferation involved in outflow tract morphogenesis(GO:0061325)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.2	GO:0070945	neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0	0.7	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.1	GO:0035330	regulation of hippo signaling(GO:0035330)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.2	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.2	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.0	0.1	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.7	GO:0035115	embryonic forelimb morphogenesis(GO:0035115)
0.0	0.2	GO:1902221	L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0072125	negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194)
0.0	0.0	GO:0060982	coronary artery morphogenesis(GO:0060982)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:0032346	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0	0.2	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.0	0.1	GO:0071918	urea transmembrane transport(GO:0071918)
0.0	0.1	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0002586	regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0	0.2	GO:0046643	regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.0	0.2	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0035633	maintenance of blood-brain barrier(GO:0035633)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.0	0.2	GO:0006577	amino-acid betaine metabolic process(GO:0006577)
0.0	0.0	GO:0060535	trachea cartilage morphogenesis(GO:0060535)
0.0	0.0	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:1903972	regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.0	0.1	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
0.0	0.1	GO:0046909	intermembrane transport(GO:0046909)
0.0	0.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.2	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0009750	response to fructose(GO:0009750)
0.0	0.1	GO:0071896	protein localization to adherens junction(GO:0071896)
0.0	0.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0072530	purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642)
0.0	0.1	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.0	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.3	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.0	0.2	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.1	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0	0.1	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0	0.1	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.0	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.0	GO:0061110	dense core granule biogenesis(GO:0061110)
0.0	0.1	GO:0019355	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.0	0.2	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0	0.1	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.1	GO:0021776	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.2	GO:0046130	purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0	0.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0090031	positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.1	GO:0033275	actin-myosin filament sliding(GO:0033275)
0.0	0.1	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.0	0.0	GO:1902302	regulation of potassium ion export(GO:1902302)
0.0	0.1	GO:0071361	cellular response to ethanol(GO:0071361)
0.0	0.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.0	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.3	GO:0048843	negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0	0.1	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.0	0.2	GO:0002755	MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0	0.1	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.0	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.0	0.1	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.0	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0051121	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.0	GO:2000020	positive regulation of male gonad development(GO:2000020)
0.0	0.1	GO:0051036	regulation of endosome size(GO:0051036)
0.0	0.1	GO:0002457	T cell antigen processing and presentation(GO:0002457)
0.0	0.1	GO:0019321	pentose metabolic process(GO:0019321)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.0	GO:0005984	disaccharide metabolic process(GO:0005984)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.0	GO:0018916	nitrobenzene metabolic process(GO:0018916)
0.0	0.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.0	GO:1905005	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.0	0.0	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.1	GO:0048102	autophagic cell death(GO:0048102)
0.0	0.0	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.0	GO:0071351	response to interleukin-18(GO:0070673) cellular response to interleukin-18(GO:0071351)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.0	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.0	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.2	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0	0.0	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.0	0.1	GO:0032827	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0	0.1	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.1	GO:0005980	glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0	0.1	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0	0.0	GO:0097461	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.0	GO:0046084	adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.0	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0071371	cellular response to gonadotropin stimulus(GO:0071371)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.0	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0070307	lens fiber cell development(GO:0070307)
0.0	0.0	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.0	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.0	0.0	GO:0003415	chondrocyte hypertrophy(GO:0003415)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.0	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.0	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0001923	B-1 B cell differentiation(GO:0001923)
0.0	0.1	GO:0006677	glycosylceramide metabolic process(GO:0006677)
0.0	0.1	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.0	GO:0030920	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.0	0.1	GO:0070070	proton-transporting V-type ATPase complex assembly(GO:0070070)
0.0	0.0	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.2	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.1	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.0	GO:1903862	positive regulation of oxidative phosphorylation(GO:1903862)
0.0	0.1	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.1	GO:2000973	regulation of pro-B cell differentiation(GO:2000973)
0.0	0.0	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	0.5	GO:0002079	inner acrosomal membrane(GO:0002079)
0.1	0.4	GO:0071953	elastic fiber(GO:0071953)
0.1	0.5	GO:0005927	muscle tendon junction(GO:0005927)
0.1	0.9	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	0.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	1.5	GO:0098644	complex of collagen trimers(GO:0098644)
0.1	0.8	GO:0030061	mitochondrial crista(GO:0030061)
0.1	0.2	GO:0005745	m-AAA complex(GO:0005745)
0.1	0.5	GO:0030314	junctional membrane complex(GO:0030314)
0.1	0.3	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.2	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.2	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.4	GO:0005861	troponin complex(GO:0005861)
0.0	0.4	GO:0070938	contractile ring(GO:0070938)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.3	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.4	GO:0001527	microfibril(GO:0001527)
0.0	0.2	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	1.1	GO:0031672	A band(GO:0031672)
0.0	0.5	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.4	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.4	GO:0034706	sodium channel complex(GO:0034706)
0.0	0.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.3	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.3	GO:0005865	striated muscle thin filament(GO:0005865)
0.0	0.3	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	1.0	GO:0030315	T-tubule(GO:0030315)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.0	0.1	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0032010	phagolysosome(GO:0032010)
0.0	0.1	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.3	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.0	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.7	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.0	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.1	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.4	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	0.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0031429	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0	3.8	GO:0005925	focal adhesion(GO:0005925)
0.0	0.0	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.5	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.0	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0	0.0	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.0	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2	0.7	GO:0009374	biotin binding(GO:0009374)
0.1	0.4	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.1	0.4	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1	0.5	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.1	0.5	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.1	0.3	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.1	0.3	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1	0.3	GO:0035939	microsatellite binding(GO:0035939)
0.1	0.3	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1	0.5	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.1	0.4	GO:0031014	troponin T binding(GO:0031014)
0.1	0.8	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1	0.5	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1	0.4	GO:0008131	primary amine oxidase activity(GO:0008131)
0.1	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.4	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.1	0.7	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	0.2	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.1	0.3	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.1	0.2	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.2	GO:0030572	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.1	0.2	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	0.2	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.1	0.4	GO:0050700	CARD domain binding(GO:0050700)
0.1	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.1	GO:0042284	sphingolipid delta-4 desaturase activity(GO:0042284)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0004565	beta-galactosidase activity(GO:0004565)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.3	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.5	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.8	GO:0001848	complement binding(GO:0001848)
0.0	0.6	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.9	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.5	GO:0017166	vinculin binding(GO:0017166)
0.0	0.3	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.3	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.2	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	1.1	GO:0016504	peptidase activator activity(GO:0016504)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.6	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0048030	disaccharide binding(GO:0048030)
0.0	0.1	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.2	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.6	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.7	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.3	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0031720	haptoglobin binding(GO:0031720)
0.0	0.1	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.3	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.1	GO:0034618	arginine binding(GO:0034618)
0.0	0.1	GO:0015265	urea channel activity(GO:0015265)
0.0	0.1	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.2	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	1.5	GO:0017022	myosin binding(GO:0017022)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.7	GO:0050699	WW domain binding(GO:0050699)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.3	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.6	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	1.0	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.3	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.1	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	0.1	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.1	GO:0019959	interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.0	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.1	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.1	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0	0.3	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.3	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.0	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.1	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.0	0.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.0	GO:0034812	2,3-dihydroxy DDT 1,2-dioxygenase activity(GO:0018542) phenanthrene dioxygenase activity(GO:0018555) 2,2',3-trihydroxybiphenyl dioxygenase activity(GO:0018556) 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity(GO:0018557) 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity(GO:0018558) 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity(GO:0018559) protocatechuate 3,4-dioxygenase type II activity(GO:0018560) 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity(GO:0018561) 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity(GO:0018562) 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity(GO:0018563) carbazole 1,9a-dioxygenase activity(GO:0018564) dihydroxydibenzothiophene dioxygenase activity(GO:0018565) 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity(GO:0018566) styrene dioxygenase activity(GO:0018567) 3,4-dihydroxyphenanthrene dioxygenase activity(GO:0018568) hydroquinone 1,2-dioxygenase activity(GO:0018569) p-cumate 2,3-dioxygenase activity(GO:0018570) 2,3-dihydroxy-p-cumate dioxygenase activity(GO:0018571) 3,5-dichlorocatechol 1,2-dioxygenase activity(GO:0018572) 2-aminophenol 1,6-dioxygenase activity(GO:0018573) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity(GO:0018574) chlorocatechol 1,2-dioxygenase activity(GO:0018575) catechol dioxygenase activity(GO:0019114) dihydroxyfluorene dioxygenase activity(GO:0019117) 5-aminosalicylate dioxygenase activity(GO:0034543) 3-hydroxy-2-naphthoate 2,3-dioxygenase activity(GO:0034803) benzo(a)pyrene 11,12-dioxygenase activity(GO:0034806) benzo(a)pyrene 4,5-dioxygenase activity(GO:0034808) 4,5-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034810) benzo(a)pyrene 9,10-dioxygenase activity(GO:0034811) 9,10-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034812) benzo(a)pyrene 7,8-dioxygenase activity(GO:0034813) 7,8-dihydroxy benzo(a)pyrene dioxygenase activity(GO:0034814) 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity(GO:0034827) 2-mercaptobenzothiazole dioxygenase activity(GO:0034834) pyridine-3,4-diol dioxygenase activity(GO:0034895) pyrene dioxygenase activity(GO:0034920) 4,5-dihydroxypyrene dioxygenase activity(GO:0034922) phenanthrene-4-carboxylate dioxygenase activity(GO:0034934) tetrachlorobenzene dioxygenase activity(GO:0034935) 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity(GO:0034936) 2,3-dihydroxydiphenyl ether dioxygenase activity(GO:0034955) diphenyl ether 1,2-dioxygenase activity(GO:0034956) arachidonate 8(S)-lipoxygenase activity(GO:0036403) 4-hydroxycatechol 1,2-dioxygenase activity(GO:0047074)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.3	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.0	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.0	GO:0030984	kininogen binding(GO:0030984)
0.0	0.0	GO:0008823	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.0	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.0	GO:1990189	peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.1	GO:0000150	recombinase activity(GO:0000150)
0.0	0.1	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.5	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.0	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.0	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0	0.1	GO:0010181	FMN binding(GO:0010181)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.4	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.7	PID GMCSF PATHWAY	GMCSF-mediated signaling events
1.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.9	PID ILK PATHWAY	Integrin-linked kinase signaling
1.1	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.1	PID ALK2 PATHWAY	ALK2 signaling events
0.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	PID ATM PATHWAY	ATM pathway
0.4	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.6	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.4	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
1.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	PID LKB1 PATHWAY	LKB1 signaling events
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	0.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	1.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.8	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.3	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.6	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.3	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.4	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	1.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.6	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.4	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.3	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	1.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.7	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.2	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.3	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.4	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.0	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.0	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.5	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.0	0.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism

Results for Nr6a1

Z-value: 0.63

Motif logo

Transcription factors associated with Nr6a1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nr6a1 motif across conditions

Conditions sorted by the z-value of the Nr6a1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr6a1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: