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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Rarb

Z-value: 0.52

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Transcription factors associated with Rarb

Gene Symbol	Gene ID	Gene Info
Rarb Ensembl NCBI MGI UniProt	ENSMUSG00000017491.8	Rarb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Rarb	chr14_16574044_16575901	73	0.919664	-0.43	6.8e-04	Click!
Rarb	chr14_16554767_16555445	19939	0.206185	0.33	1.0e-02	Click!
Rarb	chr14_16554164_16554315	20806	0.204451	0.32	1.1e-02	Click!
Rarb	chr14_16847192_16847623	28251	0.227952	-0.31	1.6e-02	Click!
Rarb	chr14_16733832_16734108	85035	0.097670	0.21	1.0e-01	Click!

Activity of the Rarb motif across conditions

Conditions sorted by the z-value of the Rarb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_102360845_102363484	3.04	Slc4a1	solute carrier family 4 (anion exchanger), member 1	1540	0.24
chr8_23035959_23037041	1.91	Ank1	ankyrin 1, erythroid	1269	0.45
chrX_150547515_150548479	1.76	Alas2	aminolevulinic acid synthase 2, erythroid	538	0.44
chr9_121451719_121452290	1.30	Trak1	trafficking protein, kinesin binding 1	2292	0.28
chr11_58275551_58275913	1.27	4930438A08Rik	RIKEN cDNA 4930438A08 gene	672	0.56
chr6_83068298_83071797	1.23	Tlx2	T cell leukemia, homeobox 2	178	0.81
chr1_177494861_177495402	1.10	Gm37306	predicted gene, 37306	27753	0.14
chr2_173034791_173035156	1.06	Gm14453	predicted gene 14453	393	0.8
chr11_83848300_83848853	0.98	Gm12576	predicted gene 12576	917	0.43
chr8_67948178_67948899	0.97	Psd3	pleckstrin and Sec7 domain containing 3	3341	0.28
chr11_19986765_19987519	0.91	Spred2	sprouty-related EVH1 domain containing 2	32572	0.2
chr1_157526787_157526938	0.89	Sec16b	SEC16 homolog B (S. cerevisiae)	715	0.64
chr10_77109606_77109767	0.87	Col18a1	collagen, type XVIII, alpha 1	4019	0.21
chr3_131269218_131269951	0.87	Hadh	hydroxyacyl-Coenzyme A dehydrogenase	2440	0.24
chr11_95354322_95355144	0.85	Fam117a	family with sequence similarity 117, member A	14771	0.11
chr15_35295781_35297332	0.85	Osr2	odd-skipped related 2	445	0.83
chr4_58546126_58546553	0.85	Lpar1	lysophosphatidic acid receptor 1	2062	0.34
chr8_3354301_3354483	0.84	Arhgef18	rho/rac guanine nucleotide exchange factor (GEF) 18	932	0.59
chr1_172548699_172548872	0.72	4933439K11Rik	RIKEN cDNA 4933439K11 gene	1884	0.2
chr5_52990921_52991150	0.72	5033403H07Rik	RIKEN cDNA 5033403H07 gene	1257	0.4
chr14_21078036_21078470	0.72	Adk	adenosine kinase	2101	0.35
chrX_106839224_106840351	0.71	Rtl3	retrotransposon Gag like 3	857	0.6
chr15_77973908_77974338	0.66	Eif3d	eukaryotic translation initiation factor 3, subunit D	3310	0.19
chr10_68157085_68157396	0.63	Arid5b	AT rich interactive domain 5B (MRF1-like)	20614	0.24
chr16_14310141_14310292	0.60	Gm15868	predicted gene 15868	1625	0.3
chr17_65606813_65607080	0.60	Vapa	vesicle-associated membrane protein, associated protein A	6609	0.17
chr10_86024993_86025483	0.60	A230060F14Rik	RIKEN cDNA A230060F14 gene	2909	0.15
chr10_121263429_121264335	0.59	Gm35404	predicted gene, 35404	20880	0.14
chr6_118771100_118771251	0.57	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	9149	0.27
chr3_14641184_14642360	0.57	Car13	carbonic anhydrase 13	45	0.97
chr8_70490321_70491265	0.57	Crlf1	cytokine receptor-like factor 1	2365	0.12
chr4_109439636_109440032	0.56	Ttc39a	tetratricopeptide repeat domain 39A	18892	0.15
chr10_8944239_8945864	0.55	Gm48728	predicted gene, 48728	6898	0.2
chr7_25379357_25380698	0.55	4732471J01Rik	RIKEN cDNA 4732471J01 gene	3204	0.12
chr9_22135450_22135674	0.54	Acp5	acid phosphatase 5, tartrate resistant	129	0.9
chr6_34517984_34518174	0.54	Gm13860	predicted gene 13860	15474	0.17
chrX_38575133_38575425	0.54	Cul4b	cullin 4B	904	0.58
chr3_95652966_95653117	0.53	Mcl1	myeloid cell leukemia sequence 1	5747	0.11
chr5_137569837_137570642	0.53	Tfr2	transferrin receptor 2	370	0.67
chr2_172261076_172261248	0.53	Mc3r	melanocortin 3 receptor	12670	0.17
chr5_115945354_115946075	0.52	Cit	citron	417	0.82
chr11_60477952_60478643	0.50	Myo15	myosin XV	1618	0.23
chr16_31066399_31067041	0.50	Xxylt1	xyloside xylosyltransferase 1	1133	0.51
chr7_100463756_100463979	0.50	C2cd3	C2 calcium-dependent domain containing 3	344	0.77
chr4_141558647_141558798	0.49	B330016D10Rik	RIKEN cDNA B330016D10 gene	12533	0.12
chr1_149960555_149961570	0.49	Pla2g4a	phospholipase A2, group IVA (cytosolic, calcium-dependent)	193	0.96
chr16_18286012_18286942	0.48	Gm24572	predicted gene, 24572	1840	0.14
chr15_81870008_81870701	0.48	Phf5a	PHD finger protein 5A	1311	0.23
chr11_53422380_53423106	0.48	Leap2	liver-expressed antimicrobial peptide 2	427	0.66
chr9_106357304_106357455	0.47	Dusp7	dual specificity phosphatase 7	11253	0.12
chr2_116020004_116021542	0.47	Meis2	Meis homeobox 2	21273	0.19
chr10_88349909_88350060	0.46	Dram1	DNA-damage regulated autophagy modulator 1	7012	0.17
chr6_5287612_5288353	0.46	Pon2	paraoxonase 2	1086	0.49
chr17_28007198_28009699	0.46	Anks1	ankyrin repeat and SAM domain containing 1	1103	0.37
chr14_70597977_70598489	0.44	Fam160b2	family with sequence similarity 160, member B2	1602	0.25
chr5_137481813_137482289	0.43	Epo	erythropoietin	3765	0.1
chr6_52233543_52234485	0.43	Hoxa10	homeobox A10	690	0.34
chr5_124574763_124574914	0.43	Eif2b1	eukaryotic translation initiation factor 2B, subunit 1 (alpha)	78	0.94
chr13_52283527_52283880	0.42	Gm48199	predicted gene, 48199	103292	0.07
chr6_114873953_114875469	0.41	Vgll4	vestigial like family member 4	309	0.91
chr8_105319792_105320155	0.40	Lrrc29	leucine rich repeat containing 29	6286	0.06
chr1_75137178_75137539	0.39	Cnppd1	cyclin Pas1/PHO80 domain containing 1	448	0.64
chr11_116429312_116429574	0.39	Ubald2	UBA-like domain containing 2	4651	0.12
chr2_27981386_27981740	0.39	Col5a1	collagen, type V, alpha 1	35878	0.15
chr17_12915129_12915280	0.39	Mrpl18	mitochondrial ribosomal protein L18	420	0.44
chr4_124695736_124696563	0.39	Gm24480	predicted gene, 24480	1458	0.2
chr11_107471149_107471443	0.39	Pitpnc1	phosphatidylinositol transfer protein, cytoplasmic 1	597	0.63
chr1_193200286_193201469	0.38	Traf3ip3	TRAF3 interacting protein 3	457	0.66
chr5_111336064_111336362	0.38	Pitpnb	phosphatidylinositol transfer protein, beta	5406	0.19
chr5_24425282_24425881	0.38	Slc4a2	solute carrier family 4 (anion exchanger), member 2	296	0.73
chr7_16230037_16230216	0.38	Gm45409	predicted gene 45409	1226	0.28
chr14_33446117_33447122	0.38	Mapk8	mitogen-activated protein kinase 8	523	0.73
chr7_116031040_116032871	0.38	Sox6os	SRY (sex determining region Y)-box 6, opposite strand	24	0.94
chr7_49764281_49764691	0.37	Htatip2	HIV-1 Tat interactive protein 2	5333	0.23
chr10_45229498_45229649	0.37	Gm27723	predicted gene, 27723	17514	0.16
chr5_130223795_130224186	0.37	Gm6598	predicted gene 6598	925	0.33
chr15_12937941_12938422	0.37	Gm49100	predicted gene, 49100	17541	0.19
chr19_4110129_4110280	0.37	Pitpnm1	phosphatidylinositol transfer protein, membrane-associated 1	277	0.73
chr6_72392212_72392477	0.36	Vamp8	vesicle-associated membrane protein 8	1641	0.22
chr11_94997390_94997735	0.36	Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	1498	0.25
chr2_84843620_84843993	0.36	Slc43a1	solute carrier family 43, member 1	3181	0.15
chr8_34061456_34061607	0.35	Gm9951	predicted gene 9951	6909	0.14
chr4_154926952_154928851	0.35	Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	176	0.92
chr2_84938213_84938457	0.35	Slc43a3	solute carrier family 43, member 3	1445	0.3
chr5_119628854_119629005	0.34	Tbx3os1	T-box 3, opposite strand 1	1336	0.34
chr9_21029266_21030734	0.34	Icam4	intercellular adhesion molecule 4, Landsteiner-Wiener blood group	546	0.46
chr13_28757451_28758760	0.34	Mir6368	microRNA 6368	47232	0.14
chr18_32552663_32553082	0.33	Gypc	glycophorin C	7108	0.21
chr2_33438550_33438701	0.33	Zbtb34	zinc finger and BTB domain containing 34	7301	0.15
chr15_79224523_79224986	0.33	Pick1	protein interacting with C kinase 1	4419	0.11
chr2_69341138_69341289	0.33	Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1387	0.41
chr7_4657800_4658971	0.33	Gm44878	predicted gene 44878	275	0.65
chr12_110973871_110974372	0.33	Ankrd9	ankyrin repeat domain 9	4134	0.14
chr4_126261968_126262137	0.32	Trappc3	trafficking protein particle complex 3	273	0.86
chr16_18342108_18342456	0.32	Tango2	transport and golgi organization 2	1615	0.2
chr10_25539576_25539847	0.32	Gm29571	predicted gene 29571	3325	0.21
chr17_35514558_35514964	0.31	CR974473.1	transcription factor 19 (Tcf19) pseudogene	1096	0.22
chr2_31060865_31061356	0.31	Fnbp1	formin binding protein 1	5666	0.19
chr17_84156320_84156518	0.31	Gm19696	predicted gene, 19696	7	0.97
chr8_122658492_122658718	0.30	Cbfa2t3	CBFA2/RUNX1 translocation partner 3	12139	0.09
chr6_5803273_5803424	0.30	Dync1i1	dynein cytoplasmic 1 intermediate chain 1	45929	0.19
chr4_119115471_119116280	0.30	Slc2a1	solute carrier family 2 (facilitated glucose transporter), member 1	6961	0.1
chr4_6196428_6196604	0.30	Ubxn2b	UBX domain protein 2B	5418	0.26
chr4_133338534_133339530	0.30	Wdtc1	WD and tetratricopeptide repeats 1	239	0.9
chr9_66915026_66915697	0.29	Rab8b	RAB8B, member RAS oncogene family	4326	0.19
chr18_62174392_62175675	0.29	Adrb2	adrenergic receptor, beta 2	4926	0.21
chr1_161750875_161751601	0.29	Gm5049	predicted gene 5049	5182	0.16
chr7_81652293_81652444	0.29	Gm26149	predicted gene, 26149	17360	0.12
chr5_107224079_107224230	0.29	Gm8145	predicted gene 8145	17469	0.14
chr11_20022067_20022218	0.29	Spred2	sprouty-related EVH1 domain containing 2	67572	0.11
chr15_103250315_103251530	0.29	Nfe2	nuclear factor, erythroid derived 2	543	0.62
chr2_74663085_74663236	0.28	Evx2	even-skipped homeobox 2	3603	0.08
chr1_132389425_132389838	0.27	Tmcc2	transmembrane and coiled-coil domains 2	687	0.59
chr8_120454389_120454680	0.27	Gm22715	predicted gene, 22715	10985	0.17
chr4_99030875_99031254	0.27	Angptl3	angiopoietin-like 3	110	0.97
chr10_128821963_128822829	0.27	Sarnp	SAP domain containing ribonucleoprotein	464	0.51
chr7_25088640_25088822	0.27	Mir6537	microRNA 6537	8444	0.11
chr17_45886050_45887093	0.26	Gm41584	predicted gene, 41584	1225	0.42
chr10_80158079_80159158	0.26	Cirbp	cold inducible RNA binding protein	7367	0.08
chr1_88094712_88095046	0.26	Ugt1a7c	UDP glucuronosyltransferase 1 family, polypeptide A7C	183	0.84
chr11_57649559_57650027	0.26	4933424L21Rik	RIKEN cDNA 4933424L21 gene	299	0.87
chr17_79918311_79919151	0.25	Gm6552	predicted gene 6552	15841	0.16
chr11_113779500_113779753	0.25	Gm11736	predicted gene 11736	22924	0.14
chr4_11128483_11128667	0.25	Gm11827	predicted gene 11827	4617	0.13
chr1_88095102_88096019	0.25	Ugt1a7c	UDP glucuronosyltransferase 1 family, polypeptide A7C	446	0.58
chr17_24478260_24478723	0.25	Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	13	0.93
chr4_136776404_136777015	0.25	Ephb2	Eph receptor B2	59134	0.1
chr15_97785974_97786429	0.24	Slc48a1	solute carrier family 48 (heme transporter), member 1	1712	0.26
chr2_74734325_74737080	0.24	Hoxd3	homeobox D3	813	0.31
chr7_28307770_28307921	0.23	Timm50	translocase of inner mitochondrial membrane 50	173	0.87
chr2_91027643_91027794	0.23	Gm13777	predicted gene 13777	3404	0.13
chr16_7006273_7006424	0.22	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	63498	0.16
chr2_38925225_38926405	0.22	Nr6a1	nuclear receptor subfamily 6, group A, member 1	402	0.74
chr17_83684633_83684800	0.22	Mta3	metastasis associated 3	21447	0.21
chr6_88123695_88124100	0.22	Mir6376	microRNA 6376	19639	0.12
chr18_37955063_37956021	0.22	Rell2	RELT-like 2	17	0.88
chr13_115376228_115376379	0.22	Gm47891	predicted gene, 47891	94102	0.08
chr8_57611661_57611812	0.22	Gm45534	predicted gene 45534	4580	0.12
chr13_104610150_104610741	0.22	2610204G07Rik	RIKEN cDNA 2610204G07 gene	74486	0.12
chr11_121548233_121548639	0.22	Tbcd	tubulin-specific chaperone d	1675	0.38
chr4_130112205_130112356	0.21	Pef1	penta-EF hand domain containing 1	4724	0.16
chr3_96255177_96255418	0.21	Gm20627	predicted gene 20627	172	0.77
chr6_52196485_52198020	0.21	Hoxaas3	Hoxa cluster antisense RNA 3	3872	0.06
chr5_125465151_125466227	0.21	Gm43756	predicted gene 43756	5808	0.12
chr10_40132385_40132661	0.21	Slc16a10	solute carrier family 16 (monocarboxylic acid transporters), member 10	9731	0.14
chr15_8967409_8968940	0.21	Ranbp3l	RAN binding protein 3-like	172	0.96
chr4_150717290_150717441	0.21	Gm16079	predicted gene 16079	38573	0.15
chr5_30920335_30921507	0.20	Khk	ketohexokinase	510	0.51
chr17_29005330_29006086	0.20	Stk38	serine/threonine kinase 38	2018	0.16
chr3_126365915_126366272	0.20	Arsj	arylsulfatase J	2409	0.33
chr6_88925895_88926135	0.20	Gm44178	predicted gene, 44178	6307	0.13
chr4_141159081_141159521	0.20	Fbxo42	F-box protein 42	11379	0.12
chr7_45093013_45094086	0.20	Rcn3	reticulocalbin 3, EF-hand calcium binding domain	1328	0.13
chr2_90942971_90943203	0.20	Celf1	CUGBP, Elav-like family member 1	2544	0.17
chr18_21152486_21153141	0.20	Gm6378	predicted pseudogene 6378	75704	0.09
chr3_95141713_95142452	0.20	Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	278	0.74
chr16_86516621_86516772	0.20	Gm49572	predicted gene, 49572	242203	0.02
chr11_11831905_11832402	0.20	Ddc	dopa decarboxylase	4127	0.22
chr2_132518446_132518597	0.19	Gm14095	predicted gene 14095	17373	0.15
chr17_29489359_29490304	0.19	Pim1	proviral integration site 1	922	0.36
chr3_102152409_102152561	0.19	Casq2	calsequestrin 2	8434	0.13
chr7_80628877_80629821	0.19	Crtc3	CREB regulated transcription coactivator 3	277	0.89
chr8_12548291_12548587	0.19	Spaca7	sperm acrosome associated 7	24590	0.14
chr14_27338331_27338622	0.19	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	2410	0.32
chr4_141286800_141287991	0.19	Gm13056	predicted gene 13056	8956	0.11
chr7_27957807_27957958	0.19	Gm10651	predicted pseudogene 10651	8119	0.11
chr6_48504124_48504282	0.19	Zfp862-ps	zinc finger protein 862, pseudogene	134	0.91
chr19_6280905_6281787	0.19	Ehd1	EH-domain containing 1	4421	0.08
chr11_55458328_55458479	0.19	Atox1	antioxidant 1 copper chaperone	2794	0.16
chr16_93744711_93744862	0.18	Dop1b	DOP1 leucine zipper like protein B	14687	0.16
chr11_95145006_95146328	0.18	Dlx4	distal-less homeobox 4	134	0.86
chr7_141276058_141276884	0.18	Cdhr5	cadherin-related family member 5	303	0.75
chr11_55077185_55077593	0.18	Ccdc69	coiled-coil domain containing 69	718	0.58
chr11_61686935_61687279	0.18	Fam83g	family with sequence similarity 83, member G	2688	0.23
chr18_11049995_11051717	0.18	Gata6os	GATA binding protein 6, opposite strand	631	0.64
chr5_123147784_123150032	0.17	Setd1b	SET domain containing 1B	5951	0.08
chr4_133041805_133043935	0.17	Ahdc1	AT hook, DNA binding motif, containing 1	3377	0.24
chr13_93428749_93428900	0.17	Gm18960	predicted gene, 18960	7508	0.15
chr10_91542314_91542465	0.17	Gm47084	predicted gene, 47084	94009	0.08
chr5_125390257_125390622	0.17	Ubc	ubiquitin C	237	0.84
chr2_170201888_170202331	0.17	Zfp217	zinc finger protein 217	54006	0.14
chr3_34834735_34834886	0.17	Gm21388	predicted gene, 21388	2340	0.34
chr17_40878627_40878778	0.17	9130008F23Rik	RIKEN cDNA 9130008F23 gene	1856	0.26
chr2_26138540_26139205	0.16	Tmem250-ps	transmembrane protein 250, pseudogene	70	0.8
chr11_96311089_96312545	0.16	Hoxb5os	homeobox B5 and homeobox B6, opposite strand	4907	0.07
chr11_96790204_96790385	0.16	Cbx1	chromobox 1	1045	0.36
chr10_45467792_45468248	0.16	Lin28b	lin-28 homolog B (C. elegans)	2181	0.36
chr5_112344442_112344593	0.16	Hps4	HPS4, biogenesis of lysosomal organelles complex 3 subunit 2	1417	0.21
chr3_84445916_84446485	0.16	Fhdc1	FH2 domain containing 1	7563	0.24
chr7_110921038_110921189	0.16	Mrvi1	MRV integration site 1	2590	0.25
chr6_49210050_49211632	0.16	Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	3320	0.2
chr19_14426285_14426840	0.16	Tle4	transducin-like enhancer of split 4	168977	0.03
chr18_61954214_61954483	0.16	Sh3tc2	SH3 domain and tetratricopeptide repeats 2	1264	0.47
chr13_107074847_107075087	0.15	Gm31452	predicted gene, 31452	11272	0.17
chr3_65658538_65659742	0.15	Mir8120	microRNA 8120	148	0.94
chr11_69419130_69420636	0.15	Kdm6b	KDM1 lysine (K)-specific demethylase 6B	6208	0.09
chr9_71213599_71213944	0.15	Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	2018	0.34
chr11_95826836_95827629	0.15	Phospho1	phosphatase, orphan 1	2732	0.15
chr9_65193224_65193667	0.15	Parp16	poly (ADP-ribose) polymerase family, member 16	1908	0.22
chr6_84882813_84883593	0.15	Exoc6b	exocyst complex component 6B	10785	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rarb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0036022	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.2	0.6	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2	0.5	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.1	0.3	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.1	0.4	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1	0.4	GO:0009804	coumarin metabolic process(GO:0009804)
0.1	0.4	GO:0061511	centriole elongation(GO:0061511)
0.1	0.3	GO:0071673	positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.1	0.5	GO:2001280	positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1	0.4	GO:0097460	ferrous iron import into cell(GO:0097460)
0.1	1.0	GO:0048484	enteric nervous system development(GO:0048484)
0.1	1.8	GO:0033014	porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.1	0.2	GO:0048793	pronephros development(GO:0048793)
0.1	0.2	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.1	0.3	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.1	0.3	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.1	0.2	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.1	0.3	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.7	GO:0046685	response to arsenic-containing substance(GO:0046685)
0.0	0.1	GO:0035799	ureter maturation(GO:0035799)
0.0	0.1	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.2	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.2	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.2	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.3	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:1904970	brush border assembly(GO:1904970)
0.0	0.2	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.1	GO:0036394	amylase secretion(GO:0036394)
0.0	0.3	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:1904659	glucose transmembrane transport(GO:1904659)
0.0	0.1	GO:1904502	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0046340	diacylglycerol catabolic process(GO:0046340)
0.0	0.1	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.0	0.3	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.1	GO:0090114	COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.1	GO:0010587	miRNA catabolic process(GO:0010587)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.0	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	0.1	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.1	GO:0033015	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015)
0.0	0.1	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.6	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.0	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.1	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.2	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0035188	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0	0.2	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.4	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.0	GO:0060931	sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0	0.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.0	GO:0048320	axial mesoderm formation(GO:0048320)
0.0	0.0	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0015919	peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0051029	rRNA transport(GO:0051029)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.0	0.0	GO:1901069	guanosine-containing compound catabolic process(GO:1901069)
0.0	0.0	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.0	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.0	0.0	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.0	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.1	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
0.0	0.0	GO:0030825	positive regulation of cGMP metabolic process(GO:0030825)
0.0	0.0	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0	0.0	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	0.4	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1	0.3	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	0.4	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.3	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.2	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.6	GO:0042588	zymogen granule(GO:0042588)
0.0	0.1	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.1	GO:0089717	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:0030689	Noc complex(GO:0030689)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.5	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:1904115	axon cytoplasm(GO:1904115)
0.0	0.1	GO:0001650	fibrillar center(GO:0001650)
0.0	0.1	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.8	GO:0014704	intercalated disc(GO:0014704)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.0	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.1	GO:0001939	female pronucleus(GO:0001939)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.1	0.9	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	0.3	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1	0.5	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.1	0.3	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.1	0.3	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	1.0	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.1	0.2	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.2	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.7	GO:0016594	glycine binding(GO:0016594)
0.0	0.5	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.4	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.6	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.2	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.1	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.2	GO:0008097	5S rRNA binding(GO:0008097)
0.0	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.2	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0031711	bradykinin receptor binding(GO:0031711)
0.0	0.1	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.0	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.1	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.2	GO:0001164	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	0.1	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.1	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0	0.4	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.0	GO:0004942	anaphylatoxin receptor activity(GO:0004942)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.1	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.0	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.6	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.1	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.3	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.0	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.0	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.0	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.0	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.5	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.5	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.5	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.3	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors