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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Relb

Z-value: 0.51

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Transcription factors associated with Relb

Gene Symbol	Gene ID	Gene Info
Relb Ensembl NCBI MGI UniProt	ENSMUSG00000002983.10	Relb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Relb	chr7_19628251_19629412	47	0.942289	-0.49	7.6e-05	Click!
Relb	chr7_19629476_19629768	184	0.877869	-0.46	1.9e-04	Click!
Relb	chr7_19631359_19631510	1996	0.157446	0.13	3.4e-01	Click!
Relb	chr7_19622440_19622591	5919	0.091779	0.10	4.6e-01	Click!
Relb	chr7_19632220_19632371	2857	0.118901	-0.08	5.2e-01	Click!

Activity of the Relb motif across conditions

Conditions sorted by the z-value of the Relb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_57320946_57324000	0.89	Hand2os1	Hand2, opposite strand 1	1245	0.3
chr19_31624383_31624534	0.60	Prkg1	protein kinase, cGMP-dependent, type I	39912	0.22
chr7_132270093_132270244	0.56	Chst15	carbohydrate sulfotransferase 15	8457	0.18
chr10_79664388_79664620	0.54	Madcam1	mucosal vascular addressin cell adhesion molecule 1	55	0.93
chr5_106457979_106459205	0.52	Barhl2	BarH like homeobox 2	426	0.82
chr12_27333974_27334218	0.51	Sox11	SRY (sex determining region Y)-box 11	8478	0.29
chr2_165741610_165742546	0.46	Eya2	EYA transcriptional coactivator and phosphatase 2	19746	0.2
chr4_150651111_150652374	0.44	Slc45a1	solute carrier family 45, member 1	355	0.88
chr11_36438334_36438485	0.44	Tenm2	teneurin transmembrane protein 2	6133	0.33
chr15_102959654_102960750	0.41	Hoxc11	homeobox C11	5775	0.08
chr11_44707619_44708111	0.40	Gm12158	predicted gene 12158	45189	0.16
chr14_122480308_122481080	0.40	Zic2	zinc finger protein of the cerebellum 2	2594	0.16
chr11_96272013_96272961	0.39	Hoxb9	homeobox B9	964	0.29
chr10_42581935_42584872	0.39	Nr2e1	nuclear receptor subfamily 2, group E, member 1	229	0.69
chr3_116157583_116157734	0.38	Gm26544	predicted gene, 26544	7179	0.14
chr12_55321703_55321892	0.37	Prorp	protein only RNase P catalytic subunit	18511	0.13
chr7_80058773_80058974	0.36	Gm21057	predicted gene, 21057	16374	0.1
chr6_30544847_30545729	0.36	Cpa2	carboxypeptidase A2, pancreatic	803	0.52
chr4_106976768_106976971	0.33	Ssbp3	single-stranded DNA binding protein 3	10443	0.19
chr1_133050009_133050364	0.33	Pik3c2b	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	4174	0.17
chr8_61360117_61360268	0.33	Sh3rf1	SH3 domain containing ring finger 1	1397	0.39
chr19_43606004_43606218	0.33	Gm20467	predicted gene 20467	4514	0.13
chr4_139578966_139579453	0.32	Iffo2	intermediate filament family orphan 2	4489	0.17
chr2_105125289_105128976	0.32	Wt1	Wilms tumor 1 homolog	78	0.91
chr14_79290059_79290488	0.32	Rgcc	regulator of cell cycle	11372	0.16
chr15_98021856_98022007	0.32	Col2a1	collagen, type II, alpha 1	17236	0.13
chr10_22818712_22820254	0.31	Tcf21	transcription factor 21	676	0.65
chr11_70043720_70044094	0.31	Dlg4	discs large MAGUK scaffold protein 4	290	0.77
chr12_111166036_111167450	0.31	Traf3	TNF receptor-associated factor 3	195	0.94
chr5_123181886_123182179	0.31	Hpd	4-hydroxyphenylpyruvic acid dioxygenase	35	0.95
chr6_52202371_52204739	0.31	Hoxa5	homeobox A5	1032	0.2
chr2_146834060_146838027	0.31	Gm14114	predicted gene 14114	3689	0.27
chr13_73268193_73269257	0.30	Gm48000	predicted gene, 48000	4505	0.18
chr16_97607830_97607981	0.28	Tmprss2	transmembrane protease, serine 2	3064	0.28
chr7_80404041_80404273	0.28	Gm44851	predicted gene 44851	112	0.9
chr3_78901151_78901971	0.28	Gm5277	predicted gene 5277	9139	0.18
chr5_135040050_135040229	0.28	Stx1a	syntaxin 1A (brain)	921	0.33
chr16_38360437_38360588	0.27	Popdc2	popeye domain containing 2	1697	0.25
chr19_44755099_44757716	0.27	Pax2	paired box 2	362	0.83
chr2_70558567_70559918	0.27	Gad1	glutamate decarboxylase 1	2800	0.19
chr6_99200508_99201678	0.27	Foxp1	forkhead box P1	38075	0.21
chr7_74006482_74006835	0.26	St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	7016	0.2
chr2_180502555_180502814	0.26	Ntsr1	neurotensin receptor 1	2457	0.25
chr5_75084798_75085749	0.26	Gsx2	GS homeobox 2	9671	0.12
chr9_50850324_50851021	0.26	Ppp2r1b	protein phosphatase 2, regulatory subunit A, beta	5371	0.16
chr9_5308602_5309732	0.26	Casp4	caspase 4, apoptosis-related cysteine peptidase	302	0.91
chr18_75405225_75405894	0.26	Smad7	SMAD family member 7	30645	0.18
chr13_71104368_71105400	0.25	Mir466f-4	microRNA 466f-4	2205	0.39
chr14_60735927_60737075	0.25	Spata13	spermatogenesis associated 13	3595	0.24
chr4_135956691_135956842	0.25	Hmgcl	3-hydroxy-3-methylglutaryl-Coenzyme A lyase	2961	0.12
chr7_35186002_35186989	0.25	Slc7a10	solute carrier family 7 (cationic amino acid transporter, y+ system), member 10	13	0.96
chr6_129449977_129450616	0.25	Clec1a	C-type lectin domain family 1, member a	1539	0.24
chr13_83732205_83734272	0.24	C130071C03Rik	RIKEN cDNA C130071C03 gene	672	0.58
chr9_119979553_119979704	0.24	Csrnp1	cysteine-serine-rich nuclear protein 1	2293	0.16
chr7_138199866_138200038	0.24	Tcerg1l	transcription elongation regulator 1-like	71377	0.12
chr19_59467055_59468700	0.23	Emx2	empty spiracles homeobox 2	5075	0.18
chr3_20147878_20148137	0.23	Gyg	glycogenin	7062	0.21
chr17_26838158_26839992	0.22	Nkx2-5	NK2 homeobox 5	2490	0.17
chr11_103770931_103772004	0.22	Wnt3	wingless-type MMTV integration site family, member 3	2683	0.23
chr4_138469035_138469593	0.22	Camk2n1	calcium/calmodulin-dependent protein kinase II inhibitor 1	15000	0.15
chr9_111021840_111021991	0.22	Ltf	lactotransferrin	501	0.64
chr19_55899988_55900963	0.22	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	2166	0.4
chr9_64240654_64240822	0.22	Uchl4	ubiquitin carboxyl-terminal esterase L4	5537	0.1
chr7_142662290_142664788	0.22	Igf2os	insulin-like growth factor 2, opposite strand	1599	0.21
chr11_32221179_32222558	0.22	Rhbdf1	rhomboid 5 homolog 1	376	0.76
chr11_96306504_96308444	0.22	Hoxb5os	homeobox B5 and homeobox B6, opposite strand	564	0.48
chr8_124249985_124250235	0.22	Galnt2	polypeptide N-acetylgalactosaminyltransferase 2	18602	0.17
chr6_52244514_52245126	0.22	Hoxa11os	homeobox A11, opposite strand	423	0.51
chr19_41699162_41699313	0.21	Slit1	slit guidance ligand 1	44249	0.14
chr11_114652641_114652923	0.21	Gm11689	predicted gene 11689	11826	0.16
chr19_44758783_44762005	0.21	Pax2	paired box 2	479	0.75
chr5_34183436_34183719	0.21	Mxd4	Max dimerization protein 4	793	0.44
chr6_125363043_125363874	0.21	Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	3031	0.17
chr2_30872666_30872817	0.21	Prrx2	paired related homeobox 2	6578	0.14
chr9_79919650_79920321	0.21	Gm3211	predicted gene 3211	6785	0.21
chr3_68470131_68470282	0.20	Schip1	schwannomin interacting protein 1	2023	0.4
chr11_67921338_67922636	0.20	Usp43	ubiquitin specific peptidase 43	166	0.74
chr7_18949615_18951696	0.20	Nova2	NOVA alternative splicing regulator 2	24767	0.07
chr6_52245764_52247193	0.20	Hoxa11os	homeobox A11, opposite strand	257	0.65
chr9_115391502_115391653	0.20	Gm25510	predicted gene, 25510	9478	0.12
chr2_70127042_70128123	0.20	Myo3b	myosin IIIB	31284	0.2
chr18_37742006_37744626	0.20	Pcdhgb6	protocadherin gamma subfamily B, 6	1222	0.15
chr9_63144078_63146888	0.20	Skor1	SKI family transcriptional corepressor 1	1497	0.38
chr5_75148315_75152589	0.20	Pdgfra	platelet derived growth factor receptor, alpha polypeptide	1840	0.2
chr6_48025548_48025741	0.20	Zfp777	zinc finger protein 777	18599	0.12
chr3_126996871_126998855	0.20	Ank2	ankyrin 2, brain	575	0.63
chr15_84301565_84301928	0.19	Gm22890	predicted gene, 22890	21606	0.13
chr9_44733806_44735185	0.19	Phldb1	pleckstrin homology like domain, family B, member 1	703	0.43
chr2_31547915_31548066	0.19	Gm13426	predicted gene 13426	4705	0.17
chr17_65905371_65905522	0.19	Gm35550	predicted gene, 35550	86	0.95
chr11_118998485_119000015	0.19	Enpp7	ectonucleotide pyrophosphatase/phosphodiesterase 7	11034	0.16
chr4_32923224_32923939	0.19	Ankrd6	ankyrin repeat domain 6	76	0.97
chr3_38568695_38568846	0.19	Gm7824	predicted gene 7824	10102	0.18
chr15_103011882_103012844	0.19	Hoxc5	homeobox C5	1452	0.19
chr9_15534305_15534456	0.19	Smco4	single-pass membrane protein with coiled-coil domains 4	13521	0.17
chr12_26534879_26535030	0.19	Gm46344	predicted gene, 46344	48163	0.11
chr9_31120528_31120906	0.19	St14	suppression of tumorigenicity 14 (colon carcinoma)	11010	0.15
chr4_149571821_149571972	0.19	Gm13066	predicted gene 13066	4106	0.14
chr11_117866335_117866496	0.19	Gm11725	predicted gene 11725	4835	0.1
chr19_5930278_5930429	0.19	Cdc42ep2	CDC42 effector protein (Rho GTPase binding) 2	5537	0.08
chr1_130550439_130551075	0.19	Gm23623	predicted gene, 23623	44919	0.1
chr8_121398391_121398555	0.19	Gm26747	predicted gene, 26747	22765	0.16
chr18_37720288_37722950	0.18	Pcdhgb4	protocadherin gamma subfamily B, 4	1236	0.14
chr11_45868095_45868246	0.18	Clint1	clathrin interactor 1	14227	0.15
chr13_30748912_30751060	0.18	Irf4	interferon regulatory factor 4	679	0.71
chr18_35627084_35627237	0.18	Slc23a1	solute carrier family 23 (nucleobase transporters), member 1	36	0.94
chr4_125122525_125123430	0.18	Zc3h12a	zinc finger CCCH type containing 12A	457	0.77
chr16_43303539_43303924	0.18	Gm37946	predicted gene, 37946	4550	0.21
chr6_134888545_134888805	0.18	Gpr19	G protein-coupled receptor 19	843	0.44
chr15_83677852_83678399	0.18	Scube1	signal peptide, CUB domain, EGF-like 1	17645	0.2
chr14_101886945_101887764	0.18	Lmo7	LIM domain only 7	3235	0.35
chr12_29937955_29939229	0.18	Pxdn	peroxidasin	542	0.84
chr4_136031178_136031911	0.18	Rpl11	ribosomal protein L11	2746	0.14
chr13_83737592_83739114	0.18	Gm33366	predicted gene, 33366	182	0.66
chr4_155451781_155451950	0.17	Cfap74	cilia and flagella associated protein 74	295	0.84
chr16_22161383_22162159	0.17	Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	321	0.89
chr11_116194935_116195163	0.17	Acox1	acyl-Coenzyme A oxidase 1, palmitoyl	3680	0.11
chr4_44694373_44694748	0.17	5730488B01Rik	RIKEN cDNA 5730488B01 gene	8240	0.14
chr11_101418651_101418802	0.17	Mir6929	microRNA 6929	527	0.44
chr10_79965080_79965231	0.17	Wdr18	WD repeat domain 18	349	0.68
chr6_52167312_52169129	0.17	Hoxaas2	Hoxa cluster antisense RNA 2	290	0.7
chr15_102950417_102951549	0.17	Hotair	HOX transcript antisense RNA (non-protein coding)	3253	0.11
chr10_50895645_50896998	0.17	Sim1	single-minded family bHLH transcription factor 1	670	0.79
chr3_148988258_148989425	0.17	Gm43573	predicted gene 43573	311	0.63
chr7_70359645_70360747	0.17	Nr2f2	nuclear receptor subfamily 2, group F, member 2	275	0.86
chr8_120833068_120833219	0.17	Gm26878	predicted gene, 26878	47063	0.12
chr11_96279294_96280222	0.16	Hoxb8	homeobox B8	2147	0.12
chr7_116034244_116034507	0.16	Sox6	SRY (sex determining region Y)-box 6	138	0.94
chr1_133068155_133068426	0.16	Gm28609	predicted gene 28609	115	0.72
chr1_75345328_75345561	0.16	Des	desmin	14885	0.09
chr19_53710843_53711000	0.16	Rbm20	RNA binding motif protein 20	33615	0.15
chr4_154948550_154949380	0.16	Hes5	hes family bHLH transcription factor 5	11958	0.11
chr2_130638035_130638438	0.16	Lzts3	leucine zipper, putative tumor suppressor family member 3	141	0.92
chr15_103002581_103003309	0.16	Hoxc6	homeobox C6	2416	0.13
chr2_30074557_30074708	0.16	Pkn3	protein kinase N3	3052	0.14
chr6_51320497_51320934	0.16	Gm32479	predicted gene, 32479	32860	0.15
chr5_113504103_113504254	0.16	Wscd2	WSC domain containing 2	13426	0.22
chr10_4080039_4080600	0.15	Gm25515	predicted gene, 25515	23994	0.18
chr17_21753488_21754324	0.15	Zfp229	zinc finger protein 229	17994	0.11
chr10_10546593_10546906	0.15	Rab32	RAB32, member RAS oncogene family	11432	0.2
chr9_34871552_34871717	0.15	Kirrel3os	kirre like nephrin family adhesion molecule 3, opposite strand	57875	0.13
chr7_70287627_70288555	0.15	Gm29327	predicted gene 29327	38315	0.11
chr2_174049677_174049894	0.15	Vamp7-ps	vesicle-associated membrane protein 7, pseudogene	2512	0.27
chr15_67040638_67040789	0.15	Gm31342	predicted gene, 31342	655	0.76
chr4_32923966_32924256	0.15	Ankrd6	ankyrin repeat domain 6	606	0.7
chr2_113757445_113759087	0.15	Grem1	gremlin 1, DAN family BMP antagonist	380	0.87
chr13_56250027_56250511	0.15	Neurog1	neurogenin 1	1894	0.26
chr17_79069824_79069975	0.15	Qpct	glutaminyl-peptide cyclotransferase (glutaminyl cyclase)	7103	0.18
chr18_37763101_37764236	0.15	Pcdhgb8	protocadherin gamma subfamily B, 8	1867	0.09
chr11_101332029_101333108	0.15	Aoc3	amine oxidase, copper containing 3	1499	0.15
chr17_29447192_29447381	0.15	Gm36199	predicted gene, 36199	1381	0.3
chr2_132305611_132305762	0.15	Cds2	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	4390	0.21
chr9_108296727_108297858	0.15	Amt	aminomethyltransferase	370	0.7
chr1_9788025_9788203	0.15	1700034P13Rik	RIKEN cDNA 1700034P13 gene	4336	0.15
chr10_18470218_18471289	0.14	Nhsl1	NHS-like 1	772	0.72
chr11_95594860_95595011	0.14	Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	7200	0.17
chr13_47645272_47645423	0.14	4930471G24Rik	RIKEN cDNA 4930471G24 gene	22203	0.27
chr18_60649080_60649231	0.14	Synpo	synaptopodin	836	0.6
chr2_10153329_10154684	0.14	Itih5	inter-alpha (globulin) inhibitor H5	435	0.76
chr2_74734325_74737080	0.14	Hoxd3	homeobox D3	813	0.31
chr2_6881874_6882908	0.14	Gm13389	predicted gene 13389	1879	0.3
chr2_163637671_163638403	0.14	0610039K10Rik	RIKEN cDNA 0610039K10 gene	6813	0.13
chr5_100358403_100358554	0.14	Gm8091	predicted gene 8091	3359	0.21
chr17_34905022_34905208	0.14	Ehmt2	euchromatic histone lysine N-methyltransferase 2	88	0.89
chr1_128643284_128643435	0.14	Cxcr4	chemokine (C-X-C motif) receptor 4	51066	0.13
chr6_52313324_52314938	0.14	Evx1	even-skipped homeobox 1	579	0.38
chr17_57148993_57149872	0.14	Cd70	CD70 antigen	345	0.79
chr2_116071729_116072658	0.14	2810405F15Rik	RIKEN cDNA 2810405F15 gene	3903	0.19
chr2_155380370_155380655	0.14	Trp53inp2	transformation related protein 53 inducible nuclear protein 2	547	0.69
chr1_152086908_152087700	0.14	1700025G04Rik	RIKEN cDNA 1700025G04 gene	2666	0.35
chr2_25213719_25213959	0.14	Stpg3	sperm tail PG rich repeat containing 3	188	0.8
chr8_34325722_34326983	0.14	Gm4889	predicted gene 4889	1558	0.28
chr14_31212442_31212593	0.14	Tnnc1	troponin C, cardiac/slow skeletal	4185	0.12
chr15_85615061_85615935	0.14	Gm49539	predicted gene, 49539	30585	0.12
chr2_18038889_18039040	0.14	A930004D18Rik	RIKEN cDNA A930004D18 gene	1227	0.31
chr6_65674892_65675628	0.13	Ndnf	neuron-derived neurotrophic factor	3670	0.28
chr9_4794566_4795419	0.13	Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	527	0.88
chr1_132194845_132194996	0.13	Mir135b	microRNA 135b	3168	0.14
chr1_138171970_138172121	0.13	Ptprc	protein tyrosine phosphatase, receptor type, C	3144	0.18
chr17_24657836_24658944	0.13	Npw	neuropeptide W	67	0.92
chr18_37690944_37692448	0.13	Pcdhgb2	protocadherin gamma subfamily B, 2	1861	0.09
chr11_101965649_101967097	0.13	Sost	sclerostin	642	0.52
chr3_89965873_89966024	0.13	Gm24046	predicted gene, 24046	2215	0.13
chr16_69721275_69721426	0.13	4930428D20Rik	RIKEN cDNA 4930428D20 gene	79031	0.12
chr7_19009114_19009265	0.13	Irf2bp1	interferon regulatory factor 2 binding protein 1	5145	0.08
chr2_165233771_165234688	0.13	Cdh22	cadherin 22	624	0.69
chr2_93189809_93190397	0.13	Trp53i11	transformation related protein 53 inducible protein 11	912	0.64
chr10_127048288_127050177	0.13	Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	561	0.49
chr6_52259871_52261414	0.13	Hoxa13	homeobox A13	160	0.84
chr3_89234782_89235064	0.13	Muc1	mucin 1, transmembrane	3452	0.07
chr1_153048305_153048494	0.13	Nmnat2	nicotinamide nucleotide adenylyltransferase 2	15025	0.19
chr19_45017873_45019099	0.13	Lzts2	leucine zipper, putative tumor suppressor 2	274	0.83
chr15_91571286_91571688	0.13	Slc2a13	solute carrier family 2 (facilitated glucose transporter), member 13	1707	0.3
chr13_49700528_49700679	0.13	Iars	isoleucine-tRNA synthetase	5203	0.12
chr3_98283534_98283685	0.13	Hmgcs2	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	3174	0.18
chr8_35699415_35699737	0.13	1700015I17Rik	RIKEN cDNA 1700015I17 gene	20373	0.14
chr9_70934045_70934653	0.13	Lipc	lipase, hepatic	264	0.92
chr17_28510395_28511318	0.13	Fkbp5	FK506 binding protein 5	501	0.58
chr11_119237088_119237239	0.13	Ccdc40	coiled-coil domain containing 40	1555	0.27
chr12_115920443_115920840	0.13	Gm42990	predicted gene 42990	12850	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Relb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:1900200	mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212)
0.1	0.3	GO:0060435	bronchiole development(GO:0060435)
0.1	0.2	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.1	0.2	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.1	0.3	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.1	0.1	GO:0060847	endothelial cell fate specification(GO:0060847)
0.1	0.3	GO:0006572	tyrosine catabolic process(GO:0006572)
0.1	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1	0.3	GO:0042940	D-amino acid transport(GO:0042940)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.2	GO:0071314	cellular response to cocaine(GO:0071314)
0.0	0.1	GO:0055118	negative regulation of cardiac muscle contraction(GO:0055118)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:1902608	regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.0	0.1	GO:0090027	negative regulation of monocyte chemotaxis(GO:0090027)
0.0	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.0	0.3	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.2	GO:0003211	cardiac ventricle formation(GO:0003211)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.1	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:0060478	acrosomal vesicle exocytosis(GO:0060478)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.2	GO:2000821	regulation of grooming behavior(GO:2000821)
0.0	0.1	GO:0006868	glutamine transport(GO:0006868)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.2	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.6	GO:0050901	leukocyte tethering or rolling(GO:0050901)
0.0	0.1	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:2000739	regulation of mesenchymal stem cell differentiation(GO:2000739)
0.0	0.2	GO:0070269	pyroptosis(GO:0070269)
0.0	0.0	GO:0072177	mesonephric duct development(GO:0072177)
0.0	0.1	GO:0072497	mesenchymal stem cell differentiation(GO:0072497)
0.0	0.1	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.1	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.2	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.1	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.0	0.0	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0072108)
0.0	0.1	GO:0061642	chemoattraction of axon(GO:0061642)
0.0	0.1	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.1	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.0	GO:2001055	positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.0	0.1	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0060931	sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0	0.1	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.0	GO:0051586	positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0	0.2	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.0	GO:0072050	S-shaped body morphogenesis(GO:0072050)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:1904261	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.5	GO:0001709	cell fate determination(GO:0001709)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.1	GO:0097475	motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.0	0.0	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.1	GO:0023041	neuronal signal transduction(GO:0023041)
0.0	0.1	GO:1900107	regulation of nodal signaling pathway(GO:1900107)
0.0	0.0	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.0	0.2	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.1	GO:1901386	negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0	0.0	GO:0070949	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.0	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.0	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.0	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635)
0.0	0.0	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:0060897	neural plate regionalization(GO:0060897)
0.0	0.1	GO:0048505	regulation of timing of cell differentiation(GO:0048505)
0.0	0.0	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.0	GO:0048320	axial mesoderm formation(GO:0048320)
0.0	0.1	GO:0072148	epithelial cell fate commitment(GO:0072148)
0.0	0.1	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.0	0.0	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.0	GO:0002877	regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.0	0.1	GO:0030046	parallel actin filament bundle assembly(GO:0030046)
0.0	0.0	GO:0003164	His-Purkinje system development(GO:0003164)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.0	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.0	GO:0033693	neurofilament bundle assembly(GO:0033693)
0.0	0.1	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.0	0.1	GO:0036233	glycine import(GO:0036233)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.0	GO:1902338	negative regulation of apoptotic process involved in morphogenesis(GO:1902338)
0.0	0.0	GO:1903232	melanosome assembly(GO:1903232)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0034628	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0	0.0	GO:0072025	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.0	0.0	GO:0071649	regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.0	0.0	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
0.0	0.0	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis(GO:0003253)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.0	0.1	GO:0032280	symmetric synapse(GO:0032280)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0072534	perineuronal net(GO:0072534)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:1990696	USH2 complex(GO:1990696)
0.0	0.3	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.2	GO:0097440	apical dendrite(GO:0097440)
0.0	0.1	GO:0005767	secondary lysosome(GO:0005767)
0.0	0.1	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.0	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0098634	protein binding involved in cell-matrix adhesion(GO:0098634)
0.1	0.2	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.1	0.9	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.1	0.2	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.3	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.1	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.3	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.4	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.0	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.0	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.3	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.1	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.0	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	0.0	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon