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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Scrt2

Z-value: 0.57

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Transcription factors associated with Scrt2

Gene Symbol	Gene ID	Gene Info
Scrt2 Ensembl NCBI MGI UniProt	ENSMUSG00000060257.2	Scrt2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Scrt2	chr2_152084535_152084698	3087	0.185283	-0.49	5.9e-05	Click!
Scrt2	chr2_152086279_152087493	5357	0.151051	-0.48	9.0e-05	Click!
Scrt2	chr2_152084019_152084489	2725	0.198688	-0.45	3.1e-04	Click!
Scrt2	chr2_152083384_152083946	2136	0.234271	-0.41	1.0e-03	Click!
Scrt2	chr2_152085191_152085589	3861	0.167396	-0.41	1.2e-03	Click!

Activity of the Scrt2 motif across conditions

Conditions sorted by the z-value of the Scrt2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_114051146_114052179	2.57	Actc1	actin, alpha, cardiac muscle 1	1225	0.4
chr16_14707769_14707934	1.32	Snai2	snail family zinc finger 2	1999	0.4
chr11_106381435_106381885	1.23	Icam2	intercellular adhesion molecule 2	859	0.5
chr18_61652982_61653392	1.20	Mir143	microRNA 143	3929	0.13
chr14_101884566_101885570	1.19	Lmo7	LIM domain only 7	949	0.69
chr13_94062433_94063410	1.17	Lhfpl2	lipoma HMGIC fusion partner-like 2	5089	0.2
chr7_46237720_46238666	1.16	Ush1c	USH1 protein network component harmonin	271	0.88
chr12_59129039_59129247	1.14	Mia2	MIA SH3 domain ER export factor 2	577	0.66
chr18_11053961_11055254	1.11	Gata6	GATA binding protein 6	431	0.83
chr7_19399234_19400287	1.09	Klc3	kinesin light chain 3	118	0.89
chr8_57213759_57214585	1.07	Gm17994	predicted gene, 17994	77880	0.08
chr1_155990531_155990714	1.05	Gm9694	predicted gene 9694	17304	0.12
chr6_39380969_39382023	1.03	Rab19	RAB19, member RAS oncogene family	321	0.84
chr2_120153312_120153463	1.02	Ehd4	EH-domain containing 4	1075	0.49
chr10_38967267_38967717	1.00	Lama4	laminin, alpha 4	1820	0.42
chr2_77168707_77169120	0.98	Ccdc141	coiled-coil domain containing 141	1663	0.41
chr16_43363086_43363291	0.98	Zbtb20	zinc finger and BTB domain containing 20	140	0.83
chr7_17060653_17061482	0.94	Hif3a	hypoxia inducible factor 3, alpha subunit	1317	0.27
chr6_54330304_54330947	0.93	9130019P16Rik	RIKEN cDNA 9130019P16 gene	3284	0.22
chr2_168589071_168590755	0.89	Nfatc2	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	278	0.93
chr12_90737821_90739146	0.89	Dio2	deiodinase, iodothyronine, type II	45	0.78
chr2_118112796_118113528	0.88	Thbs1	thrombospondin 1	1286	0.33
chr3_53657521_53658180	0.85	Frem2	Fras1 related extracellular matrix protein 2	495	0.76
chr11_55417729_55419811	0.81	Sparc	secreted acidic cysteine rich glycoprotein	1128	0.44
chr7_105738238_105738468	0.80	Rrp8	ribosomal RNA processing 8, methyltransferase, homolog (yeast)	968	0.29
chr5_116288594_116290345	0.80	Ccdc60	coiled-coil domain containing 60	484	0.71
chr13_102903771_102904870	0.80	Mast4	microtubule associated serine/threonine kinase family member 4	1466	0.56
chr2_35463798_35464176	0.78	Ggta1	glycoprotein galactosyltransferase alpha 1, 3	756	0.55
chr1_153279868_153280137	0.77	Gm38009	predicted gene, 38009	7188	0.18
chr4_127311434_127313205	0.76	Gja4	gap junction protein, alpha 4	1720	0.26
chrX_133980931_133982115	0.75	Sytl4	synaptotagmin-like 4	260	0.92
chr5_123318053_123318557	0.74	Gm15857	predicted gene 15857	7981	0.1
chr10_44011393_44011544	0.72	Crybg1	crystallin beta-gamma domain containing 1	7099	0.19
chr4_14621039_14622190	0.72	Slc26a7	solute carrier family 26, member 7	55	0.99
chr10_42581935_42584872	0.72	Nr2e1	nuclear receptor subfamily 2, group E, member 1	229	0.69
chr9_110764325_110764587	0.71	Myl3	myosin, light polypeptide 3	810	0.48
chr15_7272973_7273124	0.71	Egflam	EGF-like, fibronectin type III and laminin G domains	18280	0.24
chr2_137107794_137108485	0.71	Jag1	jagged 1	8505	0.28
chr5_124528520_124529412	0.71	Gm43034	predicted gene 43034	2167	0.16
chr17_81736193_81736564	0.70	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	1999	0.44
chr8_72137457_72137608	0.69	Tpm4	tropomyosin 4	1724	0.17
chr17_48019794_48019945	0.69	Gm14871	predicted gene 14871	16297	0.12
chr10_117235571_117236047	0.69	9530003J23Rik	RIKEN cDNA 9530003J23 gene	2845	0.16
chr9_123489714_123489865	0.69	Limd1	LIM domains containing 1	9179	0.18
chr18_42053706_42054633	0.68	Sh3rf2	SH3 domain containing ring finger 2	459	0.84
chr4_58286744_58287250	0.67	Musk	muscle, skeletal, receptor tyrosine kinase	822	0.73
chr6_88200114_88201718	0.66	Gata2	GATA binding protein 2	3	0.96
chr2_6352474_6353269	0.66	Usp6nl	USP6 N-terminal like	138	0.96
chr4_49691879_49692113	0.65	Ppp3r2	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)	9972	0.18
chr18_61256820_61257406	0.65	Rps2-ps10	ribosomal protein S2, pseudogene 10	2848	0.23
chr7_128205575_128206445	0.62	Cox6a2	cytochrome c oxidase subunit 6A2	377	0.67
chr12_118660796_118661641	0.61	Gm9267	predicted gene 9267	58541	0.12
chr7_128003842_128005372	0.60	Trim72	tripartite motif-containing 72	229	0.69
chr18_5027813_5027964	0.59	Svil	supervillin	7278	0.31
chr7_135526475_135527168	0.57	Clrn3	clarin 3	1833	0.31
chr7_100657972_100658903	0.57	Plekhb1	pleckstrin homology domain containing, family B (evectins) member 1	15	0.96
chr1_171767462_171768093	0.57	Slamf1	signaling lymphocytic activation molecule family member 1	622	0.59
chr4_56944091_56945052	0.56	Tmem245	transmembrane protein 245	2840	0.22
chr8_124991174_124991811	0.55	Tsnax	translin-associated factor X	21505	0.13
chr1_173802084_173802692	0.55	Ifi203-ps	interferon activated gene 203, pseudogene	4118	0.16
chr2_152626740_152627949	0.54	Rem1	rad and gem related GTP binding protein 1	391	0.68
chr16_5131498_5132854	0.54	Ppl	periplakin	234	0.89
chr15_80012110_80012261	0.54	Gm41361	predicted gene, 41361	146	0.89
chr9_44726537_44726746	0.54	Phldb1	pleckstrin homology like domain, family B, member 1	155	0.89
chr7_30972587_30974196	0.54	Lsr	lipolysis stimulated lipoprotein receptor	24	0.84
chr8_119437065_119437967	0.52	Osgin1	oxidative stress induced growth inhibitor 1	327	0.86
chr5_81519288_81520108	0.51	Gm43084	predicted gene 43084	16028	0.29
chr6_129181703_129182081	0.51	Clec2d	C-type lectin domain family 2, member d	1277	0.31
chrX_135574770_135575114	0.51	Nxf7	nuclear RNA export factor 7	11191	0.12
chr9_21797731_21798548	0.51	Kank2	KN motif and ankyrin repeat domains 2	364	0.77
chr6_51269852_51270940	0.50	Mir148a	microRNA 148a	486	0.83
chr3_107356954_107357548	0.50	Gm5279	predicted gene 5279	14296	0.16
chr9_118975609_118975835	0.50	Ctdspl	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	45855	0.1
chr4_57560440_57561163	0.50	Pakap	paralemmin A kinase anchor protein	7358	0.28
chr2_155611238_155612364	0.50	Myh7b	myosin, heavy chain 7B, cardiac muscle, beta	589	0.53
chr8_61908416_61909024	0.49	4930512H18Rik	RIKEN cDNA 4930512H18 gene	4340	0.19
chr11_72409874_72410296	0.49	Smtnl2	smoothelin-like 2	1626	0.27
chr16_16213032_16214454	0.49	Pkp2	plakophilin 2	425	0.85
chr1_72873610_72874834	0.49	Igfbp5	insulin-like growth factor binding protein 5	53	0.98
chr16_57551520_57552150	0.48	Filip1l	filamin A interacting protein 1-like	2593	0.35
chr16_10313185_10314434	0.48	Emp2	epithelial membrane protein 2	62	0.97
chr16_23110812_23112317	0.48	Gm24616	predicted gene, 24616	53	0.67
chr16_92358680_92359210	0.48	Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	71	0.96
chr2_167542481_167542796	0.47	Snai1	snail family zinc finger 1	4443	0.14
chr19_7557459_7558480	0.47	Plaat3	phospholipase A and acyltransferase 3	484	0.77
chr2_59158310_59158473	0.46	Ccdc148	coiled-coil domain containing 148	2143	0.28
chr2_4299460_4299841	0.46	Frmd4a	FERM domain containing 4A	868	0.47
chr12_17324246_17325364	0.46	Atp6v1c2	ATPase, H+ transporting, lysosomal V1 subunit C2	75	0.96
chr16_23984336_23985564	0.46	Gm37419	predicted gene, 37419	3532	0.2
chr11_87662563_87663695	0.45	Rnf43	ring finger protein 43	42	0.96
chr2_158145151_158146425	0.45	Tgm2	transglutaminase 2, C polypeptide	578	0.71
chr6_136660962_136662291	0.45	Plbd1	phospholipase B domain containing 1	247	0.91
chr2_121441930_121443212	0.45	Ell3	elongation factor RNA polymerase II-like 3	30	0.93
chr8_106136230_106137393	0.45	Esrp2	epithelial splicing regulatory protein 2	2	0.77
chr17_45626838_45627013	0.44	Gm25008	predicted gene, 25008	6246	0.1
chr3_108364558_108365384	0.44	Mybphl	myosin binding protein H-like	60	0.94
chr5_119681870_119683681	0.44	Tbx3	T-box 3	2526	0.22
chr15_97049553_97050500	0.44	Slc38a4	solute carrier family 38, member 4	61	0.98
chr9_58156326_58158409	0.44	Islr	immunoglobulin superfamily containing leucine-rich repeat	1178	0.35
chr9_31130557_31131972	0.43	St14	suppression of tumorigenicity 14 (colon carcinoma)	463	0.79
chr2_174287268_174287478	0.43	Gnasas1	GNAS antisense RNA 1	1938	0.21
chr13_113013114_113013713	0.43	Mcidas	multiciliate differentiation and DNA synthesis associated cell cycle protein	19568	0.08
chr7_28370288_28370439	0.42	Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	1145	0.24
chr10_17797266_17797516	0.42	Txlnb	taxilin beta	1135	0.43
chr4_95107063_95107214	0.42	Junos	jun proto-oncogene, opposite strand	8434	0.14
chr2_140763294_140763859	0.42	Flrt3	fibronectin leucine rich transmembrane protein 3	92107	0.09
chr16_8108271_8108713	0.42	Gm49535	predicted gene, 49535	4704	0.34
chr11_68555954_68556965	0.42	Mfsd6l	major facilitator superfamily domain containing 6-like	273	0.89
chr2_139679952_139680200	0.41	Ism1	isthmin 1, angiogenesis inhibitor	1898	0.34
chr6_33057859_33058010	0.41	Chchd3	coiled-coil-helix-coiled-coil-helix domain containing 3	2283	0.28
chr7_89405888_89406433	0.41	Fzd4	frizzled class receptor 4	1805	0.24
chr8_71523614_71524679	0.41	Gm7850	predicted gene 7850	572	0.48
chr9_40877257_40878943	0.40	Bsx	brain specific homeobox	3973	0.16
chr2_35132236_35133300	0.40	Cntrl	centriolin	510	0.77
chr13_16018459_16019177	0.40	Inhba	inhibin beta-A	4343	0.15
chr14_16572461_16573738	0.40	Rarb	retinoic acid receptor, beta	1946	0.34
chr3_10366508_10367397	0.40	Chmp4c	charged multivesicular body protein 4C	6	0.96
chr6_34862829_34863673	0.39	Tmem140	transmembrane protein 140	11	0.96
chr9_61227699_61228136	0.39	Gm34105	predicted gene, 34105	21238	0.18
chr9_21851806_21852608	0.39	Dock6	dedicator of cytokinesis 6	409	0.74
chr16_4641802_4643186	0.39	Dnaja3	DnaJ heat shock protein family (Hsp40) member A3	2505	0.16
chr11_120658808_120659482	0.38	Notumos	notum palmitoleoyl-protein carboxylesterase, opposite strand	12	0.9
chr9_66512511_66514532	0.38	Fbxl22	F-box and leucine-rich repeat protein 22	1088	0.47
chr10_58326224_58326780	0.38	Lims1	LIM and senescent cell antigen-like domains 1	3036	0.22
chr8_46490914_46491682	0.38	Acsl1	acyl-CoA synthetase long-chain family member 1	324	0.87
chr17_22685333_22685484	0.38	Gm9805	predicted gene 9805	2312	0.26
chr2_119619277_119620230	0.37	Nusap1	nucleolar and spindle associated protein 1	1024	0.3
chr18_21296515_21297047	0.37	Garem1	GRB2 associated regulator of MAPK1 subtype 1	3342	0.22
chr15_80081033_80081744	0.37	Rpl3	ribosomal protein L3	907	0.27
chr6_85837036_85837692	0.37	Nat8	N-acetyltransferase 8 (GCN5-related)	5282	0.09
chrX_53053916_53055220	0.37	Mir322	microRNA 322	219	0.66
chr6_114917046_114918071	0.37	Vgll4	vestigial like family member 4	4258	0.26
chr10_57499477_57499901	0.36	Hsf2	heat shock factor 2	685	0.68
chr1_72960515_72960666	0.36	1700027A15Rik	RIKEN cDNA 1700027A15 gene	24254	0.2
chr1_173941834_173942320	0.36	Ifi203	interferon activated gene 203	377	0.8
chr10_56377345_56379375	0.36	Gja1	gap junction protein, alpha 1	82	0.97
chrX_102187053_102187918	0.36	Rps4x	ribosomal protein S4, X-linked	748	0.53
chr11_101891234_101892171	0.36	Meox1	mesenchyme homeobox 1	2672	0.18
chr12_69447750_69448552	0.36	5830428M24Rik	RIKEN cDNA 5830428M24 gene	19241	0.14
chr13_109229388_109230388	0.36	Pde4d	phosphodiesterase 4D, cAMP specific	30766	0.25
chr10_111957572_111957832	0.36	Krr1	KRR1, small subunit (SSU) processome component, homolog (yeast)	14962	0.16
chr14_34375555_34377243	0.35	Mmrn2	multimerin 2	678	0.52
chr8_70765697_70766944	0.35	6330537M06Rik	RIKEN cDNA 6330537M06 gene	259	0.52
chr17_70997235_70997648	0.35	Myl12a	myosin, light chain 12A, regulatory, non-sarcomeric	134	0.92
chr5_35391428_35392811	0.35	4930442P19Rik	RIKEN cDNA 4930442P19 gene	207	0.9
chr8_69992523_69992674	0.35	Gatad2a	GATA zinc finger domain containing 2A	3635	0.15
chr1_86580854_86581005	0.35	Gm37152	predicted gene, 37152	871	0.4
chr9_102643756_102644501	0.35	Anapc13	anaphase promoting complex subunit 13	15616	0.12
chr19_32956612_32957351	0.34	Gm36860	predicted gene, 36860	23082	0.24
chr3_8594088_8594846	0.34	Gm18822	predicted gene, 18822	22037	0.15
chr1_157413776_157413976	0.34	2810025M15Rik	RIKEN cDNA 2810025M15 gene	898	0.4
chr8_61273636_61273787	0.34	1700001D01Rik	RIKEN cDNA 1700001D01 gene	15161	0.2
chr10_69617478_69618016	0.34	Gm46231	predicted gene, 46231	51386	0.16
chr2_115512707_115513160	0.34	3110099E03Rik	RIKEN cDNA 3110099E03 gene	726	0.75
chr9_63749888_63750053	0.34	Smad3	SMAD family member 3	1107	0.57
chr18_37821959_37823152	0.34	Gm38182	predicted gene, 38182	1324	0.18
chr11_77798312_77798528	0.33	Myo18a	myosin XVIIIA	2878	0.21
chr18_82821622_82822615	0.33	4930445N18Rik	RIKEN cDNA 4930445N18 gene	33776	0.11
chr5_96983338_96983489	0.33	Gm9484	predicted gene 9484	13951	0.12
chr15_85734856_85735435	0.33	Ppara	peroxisome proliferator activated receptor alpha	162	0.94
chr2_33218132_33218667	0.33	Angptl2	angiopoietin-like 2	2282	0.25
chr17_85607592_85608395	0.33	Six3	sine oculis-related homeobox 3	5615	0.15
chr4_41706867_41707261	0.33	Rpp25l	ribonuclease P/MRP 25 subunit-like	6470	0.09
chr9_40324933_40325121	0.33	1700110K17Rik	RIKEN cDNA 1700110K17 gene	1601	0.25
chr12_25092495_25093804	0.33	Id2	inhibitor of DNA binding 2	2938	0.22
chr7_15963733_15964484	0.33	Ehd2	EH-domain containing 2	3367	0.13
chr4_45965010_45965225	0.33	Tdrd7	tudor domain containing 7	217	0.94
chr1_136007228_136008019	0.33	Tmem9	transmembrane protein 9	527	0.63
chr1_118481967_118482873	0.32	Clasp1	CLIP associating protein 1	381	0.8
chr2_35460032_35460183	0.32	Ggta1	glycoprotein galactosyltransferase alpha 1, 3	1142	0.39
chr7_100926314_100930096	0.32	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	3902	0.17
chr2_104848924_104850114	0.32	Prrg4	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)	26	0.97
chr9_50752994_50754649	0.32	Cryab	crystallin, alpha B	574	0.54
chr11_88516893_88517089	0.31	Msi2	musashi RNA-binding protein 2	73156	0.09
chr11_72301272_72302549	0.31	Xaf1	XIAP associated factor 1	245	0.87
chr1_161713119_161713350	0.31	Gm37638	predicted gene, 37638	471	0.79
chr10_78399155_78399306	0.31	Rrp1	ribosomal RNA processing 1 homolog (S. cerevisiae)	4386	0.09
chr9_42275689_42275840	0.31	Gm36435	predicted gene, 36435	4114	0.2
chr12_3806578_3808221	0.31	Dnmt3a	DNA methyltransferase 3A	239	0.92
chr5_122102345_122102815	0.30	Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	599	0.66
chr13_112425188_112425430	0.30	Gm48876	predicted gene, 48876	1031	0.45
chr5_114512883_114513065	0.30	Gm13790	predicted gene 13790	38315	0.11
chr4_48663556_48664483	0.30	Cavin4	caveolae associated 4	505	0.78
chr1_78009156_78009351	0.30	Gm28387	predicted gene 28387	36877	0.21
chr9_7983652_7983803	0.30	Gm20416	predicted gene 20416	17889	0.14
chr17_44188075_44189373	0.30	Clic5	chloride intracellular channel 5	140	0.98
chr3_128239796_128239947	0.30	D030025E07Rik	RIKEN cDNA D030025E07 gene	8265	0.25
chr2_105129293_105129444	0.30	Wt1	Wilms tumor 1 homolog	1432	0.37
chr5_149312765_149313642	0.30	Gm19719	predicted gene, 19719	25335	0.09
chr11_76622309_76623770	0.30	Abr	active BCR-related gene	519	0.78
chr13_34650593_34650744	0.30	Pxdc1	PX domain containing 1	2013	0.21
chr3_133235248_133235399	0.30	Arhgef38	Rho guanine nucleotide exchange factor (GEF) 38	374	0.89
chr18_44383580_44383731	0.29	Dcp2	decapping mRNA 2	3128	0.28
chr8_118162236_118162415	0.29	Gm25200	predicted gene, 25200	41371	0.2
chr2_46442111_46442262	0.29	Gm13470	predicted gene 13470	524	0.85
chr3_123235460_123236700	0.29	Synpo2	synaptopodin 2	16	0.97
chr10_120169087_120169245	0.29	Gm47009	predicted gene, 47009	517	0.66
chr11_83855419_83855971	0.29	Hnf1b	HNF1 homeobox B	2735	0.21
chr2_33753588_33754077	0.29	Mvb12b	multivesicular body subunit 12B	34927	0.14
chr1_173879500_173880236	0.29	Mndal	myeloid nuclear differentiation antigen like	243	0.89

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Scrt2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.7	GO:0070460	thyroid-stimulating hormone secretion(GO:0070460)
0.3	0.9	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.3	0.9	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2	0.7	GO:0010725	regulation of primitive erythrocyte differentiation(GO:0010725)
0.2	0.6	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.2	1.0	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.2	1.0	GO:0030046	parallel actin filament bundle assembly(GO:0030046)
0.2	0.5	GO:0060672	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1	0.7	GO:2001197	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.1	0.7	GO:0019532	oxalate transport(GO:0019532)
0.1	0.5	GO:0086064	cell communication by electrical coupling involved in cardiac conduction(GO:0086064)
0.1	0.5	GO:1904395	regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1	0.5	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.1	0.5	GO:0070836	caveola assembly(GO:0070836)
0.1	0.6	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.1	0.4	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.1	0.7	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.1	0.3	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.1	0.3	GO:0002277	myeloid dendritic cell activation involved in immune response(GO:0002277)
0.1	0.7	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1	0.3	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.1	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1	0.3	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1	0.4	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	0.4	GO:0009838	abscission(GO:0009838)
0.1	0.2	GO:0021557	oculomotor nerve development(GO:0021557)
0.1	0.6	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.2	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.1	0.5	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.1	0.1	GO:0002906	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1	0.2	GO:0032910	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.1	0.3	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.1	0.5	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.1	0.2	GO:0060591	chondroblast differentiation(GO:0060591)
0.1	0.1	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.1	0.2	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.3	GO:0072675	osteoclast fusion(GO:0072675)
0.1	0.3	GO:0061314	Notch signaling involved in heart development(GO:0061314)
0.1	0.2	GO:0003164	His-Purkinje system development(GO:0003164) bundle of His development(GO:0003166)
0.1	0.2	GO:0021564	vagus nerve development(GO:0021564)
0.1	0.2	GO:0032289	central nervous system myelin formation(GO:0032289)
0.1	0.3	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.1	0.2	GO:0007525	somatic muscle development(GO:0007525)
0.1	0.2	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.1	0.3	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.1	0.2	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.1	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.0	0.2	GO:0043380	regulation of memory T cell differentiation(GO:0043380)
0.0	0.1	GO:0071673	positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.0	0.1	GO:0010446	response to alkaline pH(GO:0010446)
0.0	0.1	GO:0051466	positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0	0.8	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
0.0	1.1	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.3	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0036023	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0	0.1	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.2	GO:0046015	regulation of transcription by glucose(GO:0046015)
0.0	0.5	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.0	0.1	GO:0035740	CD8-positive, alpha-beta T cell proliferation(GO:0035740)
0.0	0.3	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.0	0.1	GO:0072050	S-shaped body morphogenesis(GO:0072050)
0.0	0.1	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.2	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.0	GO:0003273	cell migration involved in endocardial cushion formation(GO:0003273)
0.0	0.1	GO:0014016	neuroblast differentiation(GO:0014016)
0.0	0.1	GO:0046909	intermembrane transport(GO:0046909)
0.0	0.1	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.0	0.1	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.2	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.2	GO:0090166	Golgi disassembly(GO:0090166)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.2	GO:0042701	progesterone secretion(GO:0042701)
0.0	0.2	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.1	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:0002525	acute inflammatory response to non-antigenic stimulus(GO:0002525)
0.0	0.1	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.0	0.2	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0072095	regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.1	GO:1903147	negative regulation of mitophagy(GO:1903147)
0.0	0.1	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.5	GO:0032801	receptor catabolic process(GO:0032801)
0.0	0.1	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.4	GO:0006907	pinocytosis(GO:0006907)
0.0	0.2	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.3	GO:0002024	diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0	0.1	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0	0.2	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0	0.7	GO:0055090	acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0	0.2	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0014866	skeletal myofibril assembly(GO:0014866)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0048619	embryonic hindgut morphogenesis(GO:0048619)
0.0	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0033122	negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0	0.1	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.9	GO:0008088	axo-dendritic transport(GO:0008088)
0.0	0.0	GO:0061209	cell proliferation involved in mesonephros development(GO:0061209)
0.0	0.0	GO:0060128	corticotropin hormone secreting cell differentiation(GO:0060128)
0.0	0.1	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0	0.1	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.4	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.0	GO:2001137	positive regulation of endocytic recycling(GO:2001137)
0.0	0.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.6	GO:0015991	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0	0.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.0	GO:0061550	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) cranial ganglion development(GO:0061550) trigeminal ganglion development(GO:0061551) facioacoustic ganglion development(GO:1903375) dorsal root ganglion development(GO:1990791)
0.0	0.1	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.0	0.0	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	0.0	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.2	GO:0035810	positive regulation of urine volume(GO:0035810)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0043206	extracellular fibril organization(GO:0043206)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.2	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.6	GO:0035456	response to interferon-beta(GO:0035456)
0.0	0.4	GO:0072661	protein targeting to plasma membrane(GO:0072661)
0.0	0.0	GO:0042231	interleukin-13 biosynthetic process(GO:0042231)
0.0	0.2	GO:0001771	immunological synapse formation(GO:0001771)
0.0	0.1	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.0	0.0	GO:2000611	positive regulation of thyroid hormone generation(GO:2000611)
0.0	0.1	GO:0071499	response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.0	0.4	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	0.1	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	0.1	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.0	0.1	GO:0000459	exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.0	0.3	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.3	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.1	GO:0001951	intestinal D-glucose absorption(GO:0001951)
0.0	0.0	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.0	0.0	GO:0061004	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) nephrogenic mesenchyme development(GO:0072076)
0.0	0.0	GO:0048382	mesendoderm development(GO:0048382)
0.0	0.1	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.1	GO:0055119	relaxation of cardiac muscle(GO:0055119)
0.0	0.0	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0	0.0	GO:0061156	pulmonary artery morphogenesis(GO:0061156)
0.0	0.1	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0	0.1	GO:0090161	Golgi ribbon formation(GO:0090161)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.1	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.1	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.1	GO:2000010	positive regulation of protein localization to cell surface(GO:2000010)
0.0	0.5	GO:0031424	keratinization(GO:0031424)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.0	0.2	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.2	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.0	GO:1902218	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.0	GO:0015744	succinate transport(GO:0015744)
0.0	0.1	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.0	GO:2000619	negative regulation of histone H4-K16 acetylation(GO:2000619)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:0046037	GMP metabolic process(GO:0046037)
0.0	0.0	GO:0071692	protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.0	0.1	GO:0019732	antifungal humoral response(GO:0019732)
0.0	0.1	GO:0035630	bone mineralization involved in bone maturation(GO:0035630)
0.0	0.0	GO:0048769	sarcomerogenesis(GO:0048769)
0.0	0.0	GO:0043974	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.0	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0	0.1	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.0	GO:0098535	de novo centriole assembly(GO:0098535)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.0	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051) negative regulation of sprouting angiogenesis(GO:1903671)
0.0	0.0	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0042407	cristae formation(GO:0042407)
0.0	0.0	GO:0071896	protein localization to adherens junction(GO:0071896)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.1	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.3	GO:0050873	brown fat cell differentiation(GO:0050873)
0.0	0.1	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.0	GO:0072034	renal vesicle induction(GO:0072034)
0.0	0.0	GO:0061738	late endosomal microautophagy(GO:0061738)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0097512	cardiac myofibril(GO:0097512)
0.1	0.5	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1	0.5	GO:0061689	tricellular tight junction(GO:0061689)
0.1	0.7	GO:0045180	basal cortex(GO:0045180)
0.1	1.0	GO:0035253	ciliary rootlet(GO:0035253)
0.1	0.2	GO:0005914	spot adherens junction(GO:0005914)
0.1	0.6	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.1	0.4	GO:0090543	Flemming body(GO:0090543)
0.1	0.2	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.7	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.3	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.4	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.5	GO:0005916	fascia adherens(GO:0005916)
0.0	0.2	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.6	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	3.2	GO:0031674	I band(GO:0031674)
0.0	0.6	GO:0030057	desmosome(GO:0030057)
0.0	0.0	GO:1990696	USH2 complex(GO:1990696)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	1.1	GO:0032420	stereocilium(GO:0032420)
0.0	0.3	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	0.4	GO:0005605	basal lamina(GO:0005605)
0.0	0.1	GO:0002079	inner acrosomal membrane(GO:0002079)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.1	GO:0061617	MICOS complex(GO:0061617)
0.0	1.7	GO:0005604	basement membrane(GO:0005604)
0.0	0.1	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.9	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.6	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.1	GO:0032437	cuticular plate(GO:0032437)
0.0	0.1	GO:0043511	inhibin complex(GO:0043511)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.4	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.2	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.7	GO:0031985	Golgi cisterna(GO:0031985)
0.0	0.3	GO:0001741	XY body(GO:0001741)
0.0	0.2	GO:0033391	chromatoid body(GO:0033391)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.6	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.0	GO:0000125	PCAF complex(GO:0000125)
0.0	0.2	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	0.0	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.6	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	0.0	GO:1990393	3M complex(GO:1990393)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.2	0.5	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1	1.0	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	0.3	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.4	GO:0071253	connexin binding(GO:0071253)
0.1	0.3	GO:0070052	collagen V binding(GO:0070052)
0.1	0.5	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.3	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.7	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.1	0.3	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	0.3	GO:0051525	NFAT protein binding(GO:0051525)
0.1	0.2	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.1	0.7	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	0.2	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1	0.3	GO:0030250	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.3	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.6	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.5	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.3	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.4	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.3	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.3	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.9	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	3.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.4	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.8	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.2	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.2	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.5	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.4	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.5	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.3	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.1	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.0	0.1	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.4	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.4	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	1.0	GO:0017022	myosin binding(GO:0017022)
0.0	0.3	GO:0005521	lamin binding(GO:0005521)
0.0	0.3	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.6	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.1	GO:0004565	beta-galactosidase activity(GO:0004565)
0.0	0.2	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.6	GO:0043905	prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.2	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.0	0.1	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	1.0	GO:0003777	microtubule motor activity(GO:0003777)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0008097	5S rRNA binding(GO:0008097)
0.0	0.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
0.0	0.0	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0034819	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0031432	titin binding(GO:0031432)
0.0	0.2	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.4	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.0	GO:0015141	succinate transmembrane transporter activity(GO:0015141)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.2	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.0	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	0.4	GO:0005109	frizzled binding(GO:0005109)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.0	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.0	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
1.2	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
1.0	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.6	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.9	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.3	PID AURORA A PATHWAY	Aurora A signaling
0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.3	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.6	PID P73PATHWAY	p73 transcription factor network
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.7	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.7	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.9	REACTOME KINESINS	Genes involved in Kinesins
0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.4	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
2.3	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.3	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.5	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME SIGNALING BY FGFR MUTANTS	Genes involved in Signaling by FGFR mutants
0.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.3	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.7	REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.3	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+