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ENCODE: H3K4me3 ChIP-Seq of different mouse tissues during embryonic development

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Sox1

Z-value: 0.98

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Transcription factors associated with Sox1

Gene Symbol	Gene ID	Gene Info
Sox1 Ensembl NCBI MGI UniProt	ENSMUSG00000096014.1	Sox1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Sox1	chr8_12393247_12393480	1932	0.221782	0.31	1.8e-02	Click!
Sox1	chr8_12394789_12395390	206	0.880732	-0.27	3.4e-02	Click!
Sox1	chr8_12395440_12396127	488	0.504407	0.19	1.5e-01	Click!
Sox1	chr8_12394043_12394245	1151	0.353540	0.15	2.5e-01	Click!
Sox1	chr8_12394304_12394455	916	0.433980	0.11	3.9e-01	Click!

Activity of the Sox1 motif across conditions

Conditions sorted by the z-value of the Sox1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_17750183_17750783	6.01	St7	suppression of tumorigenicity 7	1091	0.38
chr2_181313043_181314281	3.79	Stmn3	stathmin-like 3	838	0.42
chr13_99513069_99513554	3.37	Map1b	microtubule-associated protein 1B	3207	0.2
chr6_55680133_55680881	3.04	Neurod6	neurogenic differentiation 6	756	0.69
chrX_23284413_23285126	3.01	Klhl13	kelch-like 13	60	0.99
chr8_14382368_14383445	2.98	Dlgap2	DLG associated protein 2	910	0.66
chr4_110282527_110283235	2.95	Elavl4	ELAV like RNA binding protein 4	3735	0.36
chr7_54866491_54866642	2.76	Gm44895	predicted gene 44895	9548	0.19
chr7_51620788_51621096	2.70	Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	1064	0.54
chr6_8948312_8949000	2.61	Nxph1	neurexophilin 1	42	0.99
chr4_24429901_24430719	2.54	Gm27243	predicted gene 27243	580	0.79
chr13_62967411_62968273	2.53	Aopep	aminopeptidase O	2949	0.22
chr3_68573207_68574269	2.45	Schip1	schwannomin interacting protein 1	1493	0.45
chrX_84076569_84077653	2.36	Dmd	dystrophin, muscular dystrophy	462	0.87
chr14_65423052_65425451	2.26	Pnoc	prepronociceptin	909	0.6
chr1_120118110_120118594	2.23	Dbi	diazepam binding inhibitor	1786	0.31
chr11_41997931_41998166	2.17	Gabrg2	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	2308	0.39
chr9_41377643_41378358	2.10	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	1439	0.4
chr5_88587035_88587274	2.01	Rufy3	RUN and FYVE domain containing 3	3360	0.21
chr12_52702153_52702917	2.00	Akap6	A kinase (PRKA) anchor protein 6	3152	0.28
chr7_62366195_62366527	1.99	Magel2	melanoma antigen, family L, 2	10649	0.18
chr2_52557337_52558561	1.96	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	611	0.74
chr19_6499251_6500132	1.87	Nrxn2	neurexin II	1856	0.23
chr12_24976343_24976494	1.84	Gm36236	predicted gene, 36236	864	0.51
chr11_34102897_34103093	1.79	4930469K13Rik	RIKEN cDNA 4930469K13 gene	4441	0.22
chr5_111425949_111427685	1.79	Gm43119	predicted gene 43119	3228	0.22
chr8_54956010_54956394	1.78	Gpm6a	glycoprotein m6a	1359	0.38
chr10_110453550_110454045	1.74	Nav3	neuron navigator 3	2407	0.34
chr4_82507895_82509049	1.71	Gm11266	predicted gene 11266	456	0.82
chr1_20892892_20893201	1.64	Paqr8	progestin and adipoQ receptor family member VIII	2440	0.18
chr12_74285521_74285936	1.58	1700086L19Rik	RIKEN cDNA 1700086L19 gene	1439	0.35
chr6_123296087_123296238	1.52	Clec4e	C-type lectin domain family 4, member e	6292	0.15
chr16_42336507_42337221	1.50	Gap43	growth associated protein 43	3787	0.3
chr3_119064938_119065089	1.50	Gm43410	predicted gene 43410	196769	0.03
chr17_78508180_78509392	1.48	Vit	vitrin	614	0.7
chr7_70372558_70372768	1.45	Nr2f2	nuclear receptor subfamily 2, group F, member 2	5928	0.13
chrX_158924759_158924985	1.43	Gm5764	predicted gene 5764	91437	0.09
chr5_51495096_51495739	1.41	Gm42615	predicted gene 42615	2501	0.23
chr5_58747985_58748136	1.36	Gm43394	predicted gene 43394	252933	0.02
chr4_24429141_24429555	1.34	Gm27243	predicted gene 27243	1542	0.44
chr1_81077232_81078427	1.34	Nyap2	neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2	246	0.96
chr11_87985633_87986121	1.34	Dynll2	dynein light chain LC8-type 2	708	0.59
chr16_33686218_33687745	1.29	Heg1	heart development protein with EGF-like domains 1	2436	0.35
chr10_115819869_115820089	1.27	Tspan8	tetraspanin 8	2695	0.36
chr14_90028075_90028226	1.27	Gm48941	predicted gene, 48941	57742	0.15
chr5_104608353_104608504	1.27	Thoc2l	THO complex subunit 2-like	67245	0.1
chr7_76889140_76890193	1.24	Gm45210	predicted gene 45210	189949	0.03
chr1_168676421_168677250	1.23	1700063I16Rik	RIKEN cDNA 1700063I16 gene	953	0.73
chr4_27987811_27988244	1.22	Tpm3-rs2	tropomyosin 3, related sequence 2	8878	0.29
chr18_60925301_60926809	1.22	Camk2a	calcium/calmodulin-dependent protein kinase II alpha	330	0.84
chr16_49572852_49573281	1.20	Ift57	intraflagellar transport 57	126167	0.05
chr6_81660825_81661326	1.20	Gm26264	predicted gene, 26264	22764	0.21
chr14_65260243_65260419	1.18	Fzd3	frizzled class receptor 3	2132	0.26
chrX_106186521_106186932	1.17	Pgk1	phosphoglycerate kinase 1	374	0.82
chr16_72030928_72031079	1.16	Gm49667	predicted gene, 49667	151959	0.04
chr7_36480723_36480874	1.15	Gm25247	predicted gene, 25247	50187	0.15
chr5_28206868_28207439	1.14	Cnpy1	canopy FGF signaling regulator 1	2869	0.27
chr8_9767652_9767828	1.14	Fam155a	family with sequence similarity 155, member A	2364	0.22
chr1_63275593_63275905	1.13	Gm24513	predicted gene, 24513	2386	0.15
chr15_85578626_85579014	1.13	Wnt7b	wingless-type MMTV integration site family, member 7B	750	0.54
chrX_119427268_119427419	1.13	Gm14926	predicted gene 14926	14091	0.29
chr10_40885530_40885990	1.13	Wasf1	WAS protein family, member 1	1933	0.32
chr6_65676533_65676711	1.04	Ndnf	neuron-derived neurotrophic factor	5032	0.25
chr9_85525791_85525942	1.03	Gm48834	predicted gene, 48834	27899	0.18
chr4_57637702_57639097	1.03	Pakap	paralemmin A kinase anchor protein	424	0.89
chr5_67746354_67746505	1.03	Gm42737	predicted gene 42737	12901	0.16
chr3_87566316_87566693	1.01	ETV3L	ets variant 3-like	15255	0.14
chr9_101862248_101863069	1.00	Gm29521	predicted gene 29521	169	0.89
chr5_125267591_125268229	1.00	Gm32585	predicted gene, 32585	4905	0.19
chr1_152764641_152764934	0.99	Rgl1	ral guanine nucleotide dissociation stimulator,-like 1	1518	0.25
chr15_44706791_44706942	0.99	Sybu	syntabulin (syntaxin-interacting)	40922	0.15
chr17_80847108_80847654	0.98	C230072F16Rik	RIKEN cDNA C230072F16 gene	49412	0.14
chr14_113319455_113319606	0.97	Tpm3-rs7	tropomyosin 3, related sequence 7	4922	0.35
chr13_83984481_83985348	0.97	Gm4241	predicted gene 4241	3077	0.26
chr1_106176006_106176160	0.97	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	4331	0.2
chr2_136058799_136059736	0.96	Lamp5	lysosomal-associated membrane protein family, member 5	164	0.96
chr5_116586161_116587058	0.96	Srrm4	serine/arginine repetitive matrix 4	5208	0.2
chr19_37176789_37177437	0.96	Cpeb3	cytoplasmic polyadenylation element binding protein 3	904	0.43
chr14_55055914_55056065	0.95	Gm20687	predicted gene 20687	496	0.57
chr10_106469534_106470969	0.92	Ppfia2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	88	0.97
chr13_104393590_104393741	0.92	Adamts6	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6	86318	0.09
chr14_79533605_79533836	0.90	Elf1	E74-like factor 1	18022	0.15
chrX_56736306_56736457	0.89	Fhl1	four and a half LIM domains 1	4252	0.19
chrX_105390628_105392456	0.88	5330434G04Rik	RIKEN cDNA 5330434G04 gene	212	0.93
chr14_61174181_61174611	0.88	Sacs	sacsin	1406	0.46
chr17_72601322_72601675	0.87	Alk	anaplastic lymphoma kinase	2329	0.39
chr1_186278091_186278855	0.87	Gm37491	predicted gene, 37491	68842	0.11
chr1_88698575_88698781	0.86	Arl4c	ADP-ribosylation factor-like 4C	3198	0.22
chr19_40510615_40511718	0.86	Sorbs1	sorbin and SH3 domain containing 1	2507	0.27
chr16_6841576_6842071	0.85	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	32601	0.26
chr7_97842700_97844158	0.84	Pak1	p21 (RAC1) activated kinase 1	494	0.83
chr4_57637428_57637579	0.84	Pakap	paralemmin A kinase anchor protein	320	0.93
chr7_126700976_126702469	0.83	Coro1a	coronin, actin binding protein 1A	373	0.64
chr12_108118899_108119566	0.83	Setd3	SET domain containing 3	4149	0.29
chr2_22775769_22775920	0.82	Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	1399	0.36
chr3_34958948_34959456	0.82	Mir6378	microRNA 6378	36551	0.2
chr16_45407023_45407415	0.81	Cd200	CD200 antigen	1645	0.32
chr3_114904046_114905354	0.81	Olfm3	olfactomedin 3	65	0.98
chr6_23877057_23877231	0.80	Cadps2	Ca2+-dependent activator protein for secretion 2	37723	0.2
chrX_101642899_101643454	0.80	Ogt	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	3036	0.21
chr13_54748886_54749162	0.79	Gprin1	G protein-regulated inducer of neurite outgrowth 1	645	0.59
chr8_83167299_83167462	0.78	Gm10645	predicted gene 10645	1210	0.39
chr5_118618819_118619232	0.78	Gm43275	predicted gene 43275	731	0.61
chr10_84754760_84756248	0.76	Rfx4	regulatory factor X, 4 (influences HLA class II expression)	558	0.8
chr4_35227017_35227268	0.76	C9orf72	C9orf72, member of C9orf72-SMCR8 complex	967	0.42
chr7_30292635_30292786	0.75	Clip3	CAP-GLY domain containing linker protein 3	752	0.37
chr11_80479429_80480178	0.74	Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	2747	0.26
chr6_42265062_42266248	0.74	Casp2	caspase 2	535	0.62
chr9_124276429_124276861	0.74	Gm39469	predicted gene, 39469	5494	0.18
chr12_103046852_103047197	0.73	Unc79	unc-79 homolog	12055	0.18
chr16_85169623_85170249	0.73	Gm27295	predicted gene, 27295	1087	0.49
chr1_45924247_45924747	0.73	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	765	0.56
chr3_149247042_149247837	0.73	Gm10287	predicted gene 10287	21694	0.18
chr8_110357180_110357331	0.72	Gm23627	predicted gene, 23627	64212	0.1
chr13_69730170_69730425	0.72	Ube2ql1	ubiquitin-conjugating enzyme E2Q family-like 1	9592	0.12
chr9_90690248_90690460	0.71	Gm2497	predicted gene 2497	43170	0.14
chr11_120647315_120648501	0.71	Myadml2	myeloid-associated differentiation marker-like 2	202	0.49
chr4_109342938_109343450	0.71	Eps15	epidermal growth factor receptor pathway substrate 15	59	0.97
chrX_51219469_51219896	0.71	Gm5388	predicted gene 5388	311	0.62
chr8_70486586_70487634	0.70	Tmem59l	transmembrane protein 59-like	214	0.81
chr7_128331239_128331398	0.70	Gm44650	predicted gene 44650	1510	0.25
chr10_102355438_102355589	0.70	Mgat4c	MGAT4 family, member C	16493	0.18
chr4_33929535_33929891	0.70	Cnr1	cannabinoid receptor 1 (brain)	3511	0.32
chr18_86601591_86601919	0.69	Gm50386	predicted gene, 50386	216	0.96
chr1_63275050_63275219	0.69	Gm24513	predicted gene, 24513	1771	0.18
chr4_43575507_43576311	0.69	Gba2	glucosidase beta 2	1855	0.14
chr6_87528586_87528758	0.69	Arhgap25	Rho GTPase activating protein 25	4563	0.17
chr11_22975402_22975952	0.69	Zrsr1	zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1	2449	0.18
chr5_114569026_114570120	0.68	Fam222a	family with sequence similarity 222, member A	1556	0.35
chr4_92562847_92562998	0.67	Gm12637	predicted gene 12637	34371	0.24
chr2_165878704_165881030	0.67	Zmynd8	zinc finger, MYND-type containing 8	35	0.65
chr12_84175369_84176722	0.67	Gm19327	predicted gene, 19327	11761	0.1
chr3_8662827_8663019	0.67	Hey1	hairy/enhancer-of-split related with YRPW motif 1	3702	0.17
chr1_111746995_111747146	0.66	Gm8173	predicted gene 8173	60705	0.13
chr14_104641438_104641957	0.66	D130009I18Rik	RIKEN cDNA D130009I18 gene	2553	0.3
chr11_30022183_30022992	0.66	Eml6	echinoderm microtubule associated protein like 6	3446	0.27
chr6_142961825_142962306	0.65	St8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	2076	0.25
chr9_47534660_47535132	0.65	Cadm1	cell adhesion molecule 1	4523	0.22
chr16_3267024_3267175	0.65	Gm23215	predicted gene, 23215	17515	0.15
chr14_105499294_105499968	0.65	4930449E01Rik	RIKEN cDNA 4930449E01 gene	843	0.63
chr5_66627738_66628132	0.65	Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	9151	0.15
chr15_25757864_25758641	0.65	Myo10	myosin X	513	0.83
chr10_19459107_19459447	0.64	Gm33104	predicted gene, 33104	27438	0.19
chr2_83814030_83814462	0.64	Fam171b	family with sequence similarity 171, member B	1610	0.34
chr18_68972113_68972264	0.64	4930546C10Rik	RIKEN cDNA 4930546C10 gene	20660	0.22
chr2_51144318_51145477	0.64	Rnd3	Rho family GTPase 3	4197	0.29
chr15_99704098_99705242	0.63	Gm34939	predicted gene, 34939	694	0.3
chr10_36509078_36510052	0.63	Hs3st5	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	2158	0.44
chr5_118726229_118726380	0.63	Gm43051	predicted gene 43051	18902	0.16
chrX_114473948_114474959	0.63	Klhl4	kelch-like 4	120	0.97
chr7_27861771_27862095	0.63	Zfp607a	zinc finger protein 607A	624	0.6
chr17_21257879_21258171	0.63	Vmn1r235	vomeronasal 1 receptor 235	1614	0.2
chr4_53632665_53633308	0.62	Fsd1l	fibronectin type III and SPRY domain containing 1-like	1270	0.45
chr3_90258630_90258781	0.62	Crtc2	CREB regulated transcription coactivator 2	260	0.8
chr1_153652756_153654124	0.62	Rgs8	regulator of G-protein signaling 8	415	0.8
chr15_61102623_61102978	0.62	Gm38563	predicted gene, 38563	55069	0.14
chr18_16753999_16754150	0.61	Gm15485	predicted gene 15485	25341	0.2
chr8_45629766_45630749	0.61	Sorbs2	sorbin and SH3 domain containing 2	2056	0.32
chr3_133309865_133310159	0.61	Gm43254	predicted gene 43254	4	0.58
chr12_49390931_49392462	0.61	3110039M20Rik	RIKEN cDNA 3110039M20 gene	1037	0.42
chr5_4100830_4101020	0.61	Cyp51	cytochrome P450, family 51	2456	0.29
chr1_139079212_139079368	0.61	Dennd1b	DENN/MADD domain containing 1B	6634	0.13
chr12_101913750_101913901	0.60	Trip11	thyroid hormone receptor interactor 11	558	0.43
chr8_84769068_84769679	0.60	Nfix	nuclear factor I/X	4023	0.13
chr11_31684159_31684376	0.59	Bod1	biorientation of chromosomes in cell division 1	12382	0.22
chr13_44839841_44841006	0.59	Jarid2	jumonji, AT rich interactive domain 2	268	0.91
chrX_160991882_160992085	0.59	Cdkl5	cyclin-dependent kinase-like 5	2721	0.36
chrX_95195777_95197048	0.58	Arhgef9	CDC42 guanine nucleotide exchange factor (GEF) 9	40	0.98
chr18_69579071_69579222	0.58	Tcf4	transcription factor 4	13842	0.24
chr8_16114826_16115241	0.58	Mir3106	microRNA 3106	53805	0.16
chr13_77128205_77128356	0.57	Slf1	SMC5-SMC6 complex localization factor 1	2996	0.28
chr19_53359518_53360664	0.57	Mxi1	MAX interactor 1, dimerization protein	9932	0.13
chr4_98094219_98094802	0.57	Gm12691	predicted gene 12691	52089	0.16
chr2_64096278_64096678	0.56	Fign	fidgetin	1510	0.59
chr17_23075779_23075930	0.56	Gm18397	predicted gene, 18397	10804	0.13
chr10_110455062_110456014	0.56	Nav3	neuron navigator 3	666	0.75
chrX_94507695_94508196	0.56	Maged1	melanoma antigen, family D, 1	29619	0.1
chr12_71533269_71533420	0.56	4930404H11Rik	RIKEN cDNA 4930404H11 gene	7263	0.24
chr5_21737191_21737965	0.56	Pmpcb	peptidase (mitochondrial processing) beta	437	0.76
chr9_39074231_39074913	0.56	Gm8543	predicted gene 8543	470	0.49
chr18_34505600_34505795	0.55	Fam13b	family with sequence similarity 13, member B	1107	0.43
chr1_136342616_136342801	0.55	Camsap2	calmodulin regulated spectrin-associated protein family, member 2	2990	0.22
chr14_122484799_122486138	0.55	Gm10837	predicted gene 10837	5118	0.12
chr3_127159846_127160676	0.55	Gm16958	predicted gene, 16958	1043	0.4
chr10_81656963_81657268	0.55	Gm10778	predicted gene 10778	4883	0.09
chr2_38621764_38621915	0.54	Gm13586	predicted gene 13586	962	0.44
chr10_109830543_109831446	0.54	Nav3	neuron navigator 3	2227	0.45
chr17_34602634_34603562	0.54	Rnf5	ring finger protein 5	278	0.66
chr18_37005167_37006150	0.54	Pcdha11	protocadherin alpha 11	455	0.55
chr5_118666380_118667254	0.53	Gm43052	predicted gene 43052	20801	0.14
chr4_152263958_152264463	0.53	Gpr153	G protein-coupled receptor 153	10022	0.12
chr2_105675959_105678109	0.53	Pax6	paired box 6	905	0.54
chr7_19932934_19933834	0.53	Igsf23	immunoglobulin superfamily, member 23	11514	0.07
chr3_134242487_134243044	0.52	Gm26691	predicted gene, 26691	2124	0.19
chr8_54964691_54964995	0.52	Gm45263	predicted gene 45263	5024	0.18
chr16_62480350_62480501	0.52	CT010569.1	NADH dehydrogenase 5, mitochondrial (mt-Nd5) pseudogene	3524	0.34
chr14_75963198_75963625	0.52	Kctd4	potassium channel tetramerisation domain containing 4	8402	0.18
chr5_116209233_116209384	0.52	Gm14507	predicted gene 14507	34398	0.13
chr18_12938034_12938774	0.52	Osbpl1a	oxysterol binding protein-like 1A	3373	0.23
chr1_52565908_52566087	0.51	Gm28178	predicted gene 28178	14294	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.4	1.6	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.4	0.8	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.2	1.0	GO:2000481	positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.2	0.7	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2	0.7	GO:0036151	phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.2	0.6	GO:0061642	chemoattraction of axon(GO:0061642)
0.2	1.4	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2	0.5	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.2	0.5	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.2	0.5	GO:0009197	dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.1	0.6	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1	0.4	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1	2.2	GO:0021542	dentate gyrus development(GO:0021542)
0.1	0.4	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.1	0.5	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1	0.4	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.1	0.3	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.1	0.3	GO:0071873	response to norepinephrine(GO:0071873)
0.1	0.3	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1	0.4	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.1	0.5	GO:0016198	axon choice point recognition(GO:0016198)
0.1	0.3	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1	1.3	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	0.4	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.1	0.7	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1	0.8	GO:0071420	cellular response to histamine(GO:0071420)
0.1	0.3	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.1	0.5	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.1	1.5	GO:0001504	neurotransmitter uptake(GO:0001504)
0.1	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1	1.4	GO:0008210	estrogen metabolic process(GO:0008210)
0.1	0.5	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.1	0.4	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.1	0.3	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1	0.3	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.1	0.7	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1	0.3	GO:0021778	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1	0.2	GO:1904252	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1	0.2	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.1	0.3	GO:0051464	positive regulation of cortisol secretion(GO:0051464)
0.1	0.3	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1	0.3	GO:0033602	negative regulation of dopamine secretion(GO:0033602)
0.1	0.3	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1	0.2	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1	0.2	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1	0.2	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1	0.6	GO:0007614	short-term memory(GO:0007614)
0.1	0.5	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.1	0.3	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.1	0.3	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.1	0.3	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1	0.4	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1	0.1	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1	0.2	GO:0033132	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1	0.3	GO:2000318	positive regulation of T-helper 17 type immune response(GO:2000318)
0.1	0.2	GO:0061091	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1	0.2	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.1	0.2	GO:2000313	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1	0.2	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.3	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.3	GO:0019348	dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.2	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0032289	central nervous system myelin formation(GO:0032289)
0.0	0.1	GO:0006680	glucosylceramide catabolic process(GO:0006680)
0.0	1.4	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.1	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.3	GO:0098597	observational learning(GO:0098597)
0.0	0.5	GO:0043970	histone H3-K9 acetylation(GO:0043970)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.3	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.0	0.2	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.2	GO:1904259	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:0090258	negative regulation of mitochondrial fission(GO:0090258)
0.0	0.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0003051	angiotensin-mediated drinking behavior(GO:0003051)
0.0	0.3	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.4	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.1	GO:0015747	urate transport(GO:0015747)
0.0	0.1	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.3	GO:0051127	positive regulation of actin nucleation(GO:0051127)
0.0	0.2	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.1	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.1	GO:1903116	positive regulation of actin filament-based movement(GO:1903116)
0.0	0.3	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844)
0.0	0.3	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0002930	trabecular meshwork development(GO:0002930)
0.0	0.1	GO:0098910	regulation of atrial cardiac muscle cell action potential(GO:0098910)
0.0	0.1	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.0	0.1	GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.1	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	0.1	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.0	0.1	GO:0072051	juxtaglomerular apparatus development(GO:0072051)
0.0	0.1	GO:1990169	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0	0.2	GO:0045161	neuronal ion channel clustering(GO:0045161)
0.0	0.2	GO:2000781	positive regulation of double-strand break repair(GO:2000781)
0.0	0.5	GO:0010569	regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0	0.1	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0	2.8	GO:0000910	cytokinesis(GO:0000910)
0.0	0.2	GO:0030836	positive regulation of actin filament depolymerization(GO:0030836)
0.0	0.3	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0	0.1	GO:1900112	regulation of histone H3-K9 trimethylation(GO:1900112)
0.0	0.1	GO:1903862	positive regulation of oxidative phosphorylation(GO:1903862)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.0	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0	0.4	GO:0019430	removal of superoxide radicals(GO:0019430)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.3	GO:0007413	axonal fasciculation(GO:0007413)
0.0	0.1	GO:0031642	negative regulation of myelination(GO:0031642)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0048194	Golgi vesicle budding(GO:0048194)
0.0	0.0	GO:1903715	regulation of aerobic respiration(GO:1903715)
0.0	0.3	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.2	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	1.5	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.0	0.1	GO:0038107	nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry(GO:1900094) nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900164)
0.0	0.0	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.3	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.0	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.2	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.1	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.0	GO:0090240	positive regulation of histone H4 acetylation(GO:0090240)
0.0	0.1	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.0	0.0	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.2	GO:0035871	protein K11-linked deubiquitination(GO:0035871)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.1	GO:0021558	trochlear nerve development(GO:0021558)
0.0	0.1	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.0	GO:0014029	neural crest formation(GO:0014029)
0.0	0.6	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.1	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.1	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.2	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.1	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.1	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.0	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:1900864	mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0	0.8	GO:0006096	glycolytic process(GO:0006096)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.2	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.0	GO:0019042	viral latency(GO:0019042)
0.0	0.1	GO:0006742	NADP catabolic process(GO:0006742)
0.0	0.0	GO:1902165	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902165)
0.0	0.0	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.0	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0	0.0	GO:0090494	catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0007194	negative regulation of adenylate cyclase activity(GO:0007194)
0.0	0.0	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.7	GO:1900006	positive regulation of dendrite development(GO:1900006)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.4	GO:0046580	negative regulation of Ras protein signal transduction(GO:0046580)
0.0	0.0	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.1	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.0	GO:1901620	regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0	0.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.0	0.1	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)
0.0	0.8	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.0	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	0.0	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.0	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0	0.1	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0007296	vitellogenesis(GO:0007296)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	0.9	GO:0032584	growth cone membrane(GO:0032584)
0.1	1.0	GO:0071437	invadopodium(GO:0071437)
0.1	1.8	GO:0031527	filopodium membrane(GO:0031527)
0.1	0.4	GO:0032010	phagolysosome(GO:0032010)
0.1	0.9	GO:0042788	polysomal ribosome(GO:0042788)
0.1	0.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	0.7	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.1	0.2	GO:1990635	proximal dendrite(GO:1990635)
0.1	1.4	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.3	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.1	0.3	GO:0002079	inner acrosomal membrane(GO:0002079)
0.1	3.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	0.2	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	0.6	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	0.7	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.7	GO:0043196	varicosity(GO:0043196)
0.0	0.9	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	0.4	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.4	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.0	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	0.2	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	1.5	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	0.5	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.3	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.1	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.6	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.1	GO:1990812	growth cone filopodium(GO:1990812)
0.0	0.4	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	1.1	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.2	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.8	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.5	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:1990696	USH2 complex(GO:1990696)
0.0	0.7	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.1	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.3	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.3	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.2	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0089701	U2AF(GO:0089701)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.0	0.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.1	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.1	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0	0.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.0	GO:0044393	microspike(GO:0044393)
0.0	0.9	GO:0030286	dynein complex(GO:0030286)
0.0	0.5	GO:0032809	neuronal cell body membrane(GO:0032809)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.2	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.0	GO:0044308	axonal spine(GO:0044308)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.4	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0019814	immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.0	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.5	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)
0.0	2.0	GO:0045211	postsynaptic membrane(GO:0045211)
0.0	0.2	GO:0097386	glial cell projection(GO:0097386)
0.0	0.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.0	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0	0.1	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.2	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0097413	Lewy body(GO:0097413)
0.0	0.0	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.0	GO:1990716	axonemal central apparatus(GO:1990716)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0044292	dendrite terminus(GO:0044292)
0.0	0.7	GO:0031526	brush border membrane(GO:0031526)
0.0	0.0	GO:0033596	TSC1-TSC2 complex(GO:0033596)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3	0.7	GO:0005519	cytoskeletal regulatory protein binding(GO:0005519)
0.3	1.4	GO:0001515	opioid peptide activity(GO:0001515)
0.2	0.7	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.2	2.1	GO:0002162	dystroglycan binding(GO:0002162)
0.2	0.5	GO:0009041	uridylate kinase activity(GO:0009041)
0.1	0.4	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.1	1.5	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.1	0.6	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.1	0.4	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.1	1.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.1	0.3	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1	0.3	GO:0042296	ISG15 transferase activity(GO:0042296)
0.1	0.7	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.3	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.1	0.3	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.6	GO:0043495	protein anchor(GO:0043495)
0.1	0.3	GO:0004966	galanin receptor activity(GO:0004966)
0.1	0.3	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.1	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.3	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.1	0.3	GO:0097001	ceramide binding(GO:0097001)
0.1	0.2	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.1	0.2	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.1	0.2	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1	1.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.1	0.4	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	0.5	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1	0.5	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.1	0.2	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.4	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.3	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.9	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.6	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.5	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.2	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.1	GO:0019862	IgA binding(GO:0019862)
0.0	0.2	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.4	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.4	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.2	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.8	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	1.0	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.1	GO:0030021	extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0	0.6	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.1	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.8	GO:0030507	spectrin binding(GO:0030507)
0.0	0.3	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.4	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0034549	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.1	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.0	0.1	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0016015	morphogen activity(GO:0016015)
0.0	0.0	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.5	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0051021	GDP-dissociation inhibitor binding(GO:0051021)
0.0	0.2	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.3	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.7	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.2	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.2	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.4	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.0	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.6	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.0	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.2	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	4.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	0.0	GO:1990715	mRNA CDS binding(GO:1990715)
0.0	0.1	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.3	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.0	0.0	GO:0001884	pyrimidine nucleoside binding(GO:0001884)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.0	GO:0048030	disaccharide binding(GO:0048030)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.9	GO:0005262	calcium channel activity(GO:0005262)
0.0	0.0	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.0	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.0	GO:0016880	acid-ammonia (or amide) ligase activity(GO:0016880)
0.0	0.1	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	0.0	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.2	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	2.8	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.0	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.7	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.5	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.4	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.5	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	1.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	1.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	0.7	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.1	1.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	0.7	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	1.7	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	0.7	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.4	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.3	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.5	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.6	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	3.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.1	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.0	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.0	0.5	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.0	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0	0.3	REACTOME SIGNALLING TO ERKS	Genes involved in Signalling to ERKs
0.0	0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	2.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	1.2	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
0.0	0.2	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.3	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0	0.2	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation